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7. Early Release - Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon - Volume 26, Number 4—April 2020 - Emerging Infectious Diseases journal - CDC

Author

Siles, Crystyan, Elson, William H, Vilcarromero, Stalin, Morrison, Amy C, Hontz, Robert D, Alava, Freddy, Valdivia, Hugo, Felices, Vidal, Guevara, Carolina, Jenkins, Sarah, Abente, Eugenio J, and Ampuero, Julia S

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Malaria, Emerging Infectious Diseases, Infectious Diseases, Vector-Borne Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Coinfection, Humans, Malaria, Vivax, Orthobunyavirus, Peru, Plasmodium vivax, Guaroa virus, Peruvian Amazon, co-infection, malaria, parasites, vector-borne infections, viruses, Public Health and Health Services, Microbiology, Clinical sciences, Epidemiology, Health services and systems
Abstract

During April-June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.

Published
2020

9. Malaria Surveillance: A Cross-sectional Study in the Peruvian Amazon Basin, 2012–2023.

Author

Sanchez, Juan F, Valdivia, Hugo O, and Pannebaker, Danielle L

Subjects
*HEALTH facilities, *PLASMODIUM vivax, *MALARIA, *MALARIA prevention, *BLOOD sampling
Abstract

Loreto, a region located in the Amazon basin, has reported more than 80% of malaria cases in Peru. Application of diagnostic methods in remote areas is challenging; hence, the identification of factors associated with Plasmodium infection is necessary to improve malaria control. A cross-sectional study was conducted in health facilities in Loreto from 2012 to 2023. Data and blood samples for malaria diagnosis were collected. We performed an analysis to identify associated factors to malaria positivity. Among 2989 participants with malaria symptoms, the prevalence was 87.6% and Plasmodium vivax was the most prevalent species (74.0%). We identified several factors associated with malaria positivity such as age, occupation, sleeping with open windows, previous malaria episodes, number of malaria episodes in the last 12 months, and others. The high prevalence of malaria and the predominance of P. vivax highlight the relevance of P. vivax -targeted control programs to reach elimination in low-endemic areas. [ABSTRACT FROM AUTHOR]

Published
2025
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10. U.S. NAMRU SOUTH's Insights and Contributions to Diagnostics in the Context of Malaria Elimination.

Author

Tapia, L Lorena, Salas, Carola J, Sanchez, Juan F, Pannebaker, Danielle L, and Valdivia, Hugo O

Subjects
RAPID diagnostic tests, ASYMPTOMATIC patients, MALARIA, INFECTIOUS disease transmission, MICROSCOPY
Abstract

Timely and accurate diagnosis is a critical aspect of malaria surveillance, treatment, and intervention campaigns. Currently, field malaria diagnostics rely almost primarily on light microscopy and rapid diagnostic tests. However, both methods miss a significant proportion of asymptomatic patients and perform poorly in low transmission settings. In this review, we present tools that have been used by U.S. Naval Medical Research Unit (NAMRU) SOUTH and its collaborators during the last 40 years for various aspects of malaria research, including clinical trials, outbreak response, and epidemiologic surveillance in South and Central America. Overall, the current and future toolbox for malaria diagnostics needs to be carefully evaluated and tailored to the malaria transmission dynamics in each focus to maximize its effectiveness and achieve the goal of malaria elimination. [ABSTRACT FROM AUTHOR]

Published
2025
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11. Safety and efficacy of once-daily risdiplam in type 2 and non-ambulant type 3 spinal muscular atrophy (SUNFISH part 2): a phase 3, double-blind, randomised, placebo-controlled trial

Author

Volpe, Joseph J., Posner, John, Kellner, Ulrich, Quinlivan, Rosaline, Daron, Aurore, Delstanche, Stéphanie, Bruninx, Romain, Dal Farra, Fabian, Schneider, Olivier, Deconinck, Nicolas, Balikova, Irina, Delbeke, Patricia, Joniau, Inge, Tahon, Valentine, Wittevrongel, Sylvia, De Vos, Elke, Goemans, Nathalie, Casteels, Ingele, De Waele, Liesbeth, Cassiman, Catherine, Prové, Lies, Kinoo, David, Vancampenhout, Lisa, Van Den Hauwe, Marleen, Van Impe, Annelies, Prufer de Queiroz Campos Araujo, Alexandra, Chacon Pereira, Aline, Nardes, Flávia, Haefeli, Lorena, Rossetto, Julia, Ferreira Rebel, Marcos, Almeida Pereira, Jaqueline, Campbell, Craig, Sharan, Sapna, McDonald, Wendy, Scholtes, Cheryl, Mah, Jean, Sframeli, Maria, Chiu, Angela, Hagel, Jane, Oskoui, Maryam, Beneish, Raquel, Cariou-Palmer, Gaela, Pham, Connie, Toffoli, Daniela, Arpin, Stephanie, Turgeon Desilets, Sarah, Wang, Yi, Hu, Chaoping, Huan, Jianfeng, Qian, Chen, Shen, Li, Xiao, Ying, Zhou, Zhenxuan, Li, Hui, Wang, Sujuan, Xiong, Hui, Chang, Xingzhi, Dong, Hui, Liu, Ying, Sang, Tian, Wei, Cuijie, Wen, Jing, Cao, Yiwen, Ly, Xingyao, Zhao, Jingjing, Li, Wenzhu, Qin, Lun, Barisic, Nina, Galiot Delic, Martina, Ivkic, Petra Kristina, Vukojevic, Nenad, Kern, Ivana, Najdanovic, Boris, Skugor, Marin, Servais, Laurent, Boespflug-Tanguy, Odile, Gidaro, Teresa, Seferian, Andreea, De Lucia, Silvana, Barreau, Emmanuel, Mnafek, Nabila, Momtchilova, Marta Milkova, Peche, Helene, Valherie, Carole, Grange, Allison, Lilien, Charlotte, Milascevic, Darko, Tachibana, Shotaro, Ravelli, Claudia, Cardas, Ruxandra, Taytard, Jessica, Aubertin, Guillaume, Vanden Brande, Laure, Davion, Jean-Baptiste, Coopman, Stephanie, Bouacha, Ikram, Debruyne, Philippe, Defoort, Sabine, Derlyn, Gilles, Leroy, Florian, Danjoux, Loïc, Guilbaud, Julie, Desguerre, Isabelle, Barnérias, Christine, Semeraro, Michaela, Bremond-Gignac, Dominique, Bruere, Lenaic, Rateaux, Maxence, Deladrière, Élodie, Germa, Virginie, Pereon, Yann, Mercie, Sandra, Billaud, Fanny, Le Goff, Lucie, Letellier, Guy, Vuillerot, Carole, Portefaix, Aurélie, De-Montferrand, Camille, Le-Goff, Laure, Fontaine, Stephanie, Saidi, Manel, Bouzid, Nabil, Barriere, Aurélie, Tinat, Marie, Kirschner, Janbernd, Dreesbach, Michelle, Lagréze, Wolf, Michaelis, Bettina, Molnar, Fanni, Seger, Dorina, Vogt, Sibylle, Bertini, Enrico, D'Amico, Adele, Petroni, Sergio, Bonetti, Anna Maria, Carlesi, Adelina, Mizzoni, Irene, Bruno, Claudio, Priolo, Enrico, Rao, Giuseppe, Morando, Simone, Tacchetti, Paola, Zuffi, Ambra, Comi, Giacomo Pietro, Brusa, Roberta, Corti, Stefania, Daniele, Velardo, Govoni, Alessandra, Magri, Francesca, Minorini, Valeria, Osnaghi, Silvia Gabriella, Abbati, Francesca, Fassini, Federica, Foa, Michaela, Lopopolo, Amaqlia, Meneri, Megi, Zoppas, Francesca, Parente, Valeria, Baranello, Giovanni, Masson, Riccardo, Bianchi Marzoli, Stefania, Santarsiero, Diletta, Garcia Sierra, Myriam, Tremolada, Gemma, Arnoldi, Maria Teresa, Vigano, Marta, Zanin, Riccardo, Mercuri, Eugenio, Antonaci, Laura, de Sanctis, Roberto, Pane, Marika, Pera, Maria Carmela, Amorelli, Giulia Maria, Barresi, Costanza, D'Amico, Gugliemo, Orazi, Lorenzo, Coratti, Giorgia, Haginoya, Kazuhiro, Kato, Atsuko, Morishita, Yuko, Kira, Ryutaro, Akiyama, Kiyomu, Goto, Miwako, Mori, Yujiro, Okamoto, Misato, Tsutsui, Saki, Takatsuji, Yuta, Tanaka, Aya, Komaki, Hirofumi, Omori, Miina, Suzuki, Ippei, Takeuchi, Mizuki, Todoroki, Daisuke, Watanabe, Seji, Matsubayashi, Tomoko, Inakazu, Emi, Nagura, Hiroe, Suzuki, Akira, Usui, Manami, Ishikawa, Nobutsune, Harada, Yousuke, Fudeyasu, Kenishi, Hirata, Kazuhiko, Michiue, Kana, Ueda, Kazuyuki, Saito, Kayoko, Fujitani, Junko, Arakawa, Reiko, Takano, Kozue, Yashiro, Shigeko, Seki, Maiko, Sano, Nozomi, Fukuyama, Koji, Matsumoto, Yuki, Miyazaki, Hirofumi, Shibata, Minoru, Kobayashi, Kyoko, Nakamura, Yukie, Takeshima, Yasuhiro, Kuma, Moe, Kostera-Pruszczyk, Anna, Fraczek, Anna, Jedrzejowska, Maria, Lusakowska, Anna, Czeszyk-Piotrowicz, Agnieszka, Hautz, Wojciech, Rakusiewicz, Klaudia, Burlewicz, Malgorzata, Gierlak-Wojcicka, Zuzanna, Kepa, Malwina, Sikorski, Adam, Sobieraj, Marcin, Mazurkiewicz-Beldzinska, Maria, Lemska, Anna, Modrzejewska, Sandra, Koberda, Mateusz, Stodolska-Koberda, Urszula, Waskowska, Agnieszka, Kolendo, Jagoda, Sobierajska-Rek, Agnieszka, Steinborn, Barbara, Dalz, Magdalena, Grabowska, Julia, Hajduk, Wojciech, Janasiewicz-Karachitos, Justyna, Klimas, Monika, Stopa, Marcin, Gajewska, Ewa, Pusz, Beata, Vlodavets, Dmitry, Melnik, Evgenia, Leppenen, Natalya, Yupatova, Nataliya, Monakhova, Anastasya, Papina, Yulia, Shidlovsckaia, Olga, Milic Rasic, Vedrana, Brankovic, Vesna, Kosac, Ana, Djokic, Olivera, Jakšic, Vesna, Pepic, Ana, Martinovic, Jelena, Munell Casadesus, Francina, Tizzano, Eduardo, Martín Begué, Nieves, Wolley Dod, Charlotte, Subira, Olaia, Planas Pascual, Bernat, Toro Tamargo, Esther, Madruga Garrido, Marcos, Medina Romero, José David, Salinas, Marta Peña, Nascimento Osorio, Andrés, Díaz Cortés, Ana, Jiménez Gañan, Enrique, Suh, Simone Dowon, Medina Cantillo, Julita, Moya, Obdulia, Padros, Nuria, Urraca, Sandra Roca, Valdivia, Hugo Gonzalez, Pascual Pascual, Samuel, de Manuel, Sofía, Martin, Susana Noval, Burnham, Paul, Espinosa, Sandra, Moreno, Mercedes Martinez, Topaloglu, Haluk, Oncel, Ibrahim, Eroglu Ertugru, Nesibe, Konuskan, Bahadir, Eldem, Bora, Kadayifçilar, Sibel, Alemdaroglu, Ipek, Karaduman, Aynur Ayse, Yilmaz, Oznur Tunca, Bilgin, Neslihan, Sari, Seher, Chiriboga, Claudia, Lee, John J., Rome-Martin, Donnielle, Day, John W., Beres, Shannon, Duong, Tina, Gee, Richard, Dunaway Young, Sally, Fuerst-Recktenwald, Sabine, Marquet, Anne, Muelhardt, Nicoletta, Trundell, Dylan, Mazzone, Elena S, Nascimento, Andres, Gerber, Marianne, Gorni, Ksenija, Khwaja, Omar, Kletzl, Heidemarie, Scalco, Renata S, Staunton, Hannah, Yeung, Wai Yin, Martin, Carmen, Fontoura, Paulo, and Day, John W

Published
2022
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14. Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples

Author

Cowell, Annie N, Loy, Dorothy E, Sundararaman, Sesh A, Valdivia, Hugo, Fisch, Kathleen, Lescano, Andres G, Baldeviano, G Christian, Durand, Salomon, Gerbasi, Vince, Sutherland, Colin J, Nolder, Debbie, Vinetz, Joseph M, Hahn, Beatrice H, and Winzeler, Elizabeth A

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Microbiology, Clinical Sciences, Medical Microbiology, Infectious Diseases, Vector-Borne Diseases, Clinical Research, Biotechnology, Antimicrobial Resistance, Human Genome, Emerging Infectious Diseases, Biodefense, Genetics, Rare Diseases, Malaria, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Blood, Humans, Malaria, Vivax, Nucleic Acid Amplification Techniques, Peru, Plasmodium vivax, Sequence Analysis, DNA, Biochemistry and cell biology, Medical microbiology
Abstract

Whole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms which exhibit low densities in their hosts is challenging due to high levels of host genomic DNA (gDNA), which leads to very low coverage of the microbial genome. WGS of Plasmodium vivax, the most widely distributed form of malaria, is especially difficult because of low parasite densities and the lack of an ex vivo culture system. Current techniques used to enrich P. vivax DNA from clinical samples require significant resources or are not consistently effective. Here, we demonstrate that selective whole-genome amplification (SWGA) can enrich P. vivax gDNA from unprocessed human blood samples and dried blood spots for high-quality WGS, allowing genetic characterization of isolates that would otherwise have been prohibitively expensive or impossible to sequence. We achieved an average genome coverage of 24×, with up to 95% of the P. vivax core genome covered by ≥5 reads. The single-nucleotide polymorphism (SNP) characteristics and drug resistance mutations seen were consistent with those of other P. vivax sequences from a similar region in Peru, demonstrating that SWGA produces high-quality sequences for downstream analysis. SWGA is a robust tool that will enable efficient, cost-effective WGS of P. vivax isolates from clinical samples that can be applied to other neglected microbial pathogens.ImportanceMalaria is a disease caused by Plasmodium parasites that caused 214 million symptomatic cases and 438,000 deaths in 2015. Plasmodium vivax is the most widely distributed species, causing the majority of malaria infections outside sub-Saharan Africa. Whole-genome sequencing (WGS) of Plasmodium parasites from clinical samples has revealed important insights into the epidemiology and mechanisms of drug resistance of malaria. However, WGS of P. vivax is challenging due to low parasite levels in humans and the lack of a routine system to culture the parasites. Selective whole-genome amplification (SWGA) preferentially amplifies the genomes of pathogens from mixtures of target and host gDNA. Here, we demonstrate that SWGA is a simple, robust method that can be used to enrich P. vivax genomic DNA (gDNA) from unprocessed human blood samples and dried blood spots for cost-effective, high-quality WGS.

Published
2017

16. Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon

Author

Siles, Crystyan, Elson, William H., Vilcarromero, Stalin, Morrison, Amy C., Hontz, Robert D., Alava, Freddy, Valdivia, Hugo, Felices, Vidal, Guevara, Carolina, Jenkins, Sarah, Abente, Eugenio J., and Ampuero, Julia S.

Subjects
Diseases, Disease transmission, Infection, Malaria, Intelligence gathering, Isolation
Abstract

Since 1990 in Peru, the US Naval Medical Research Unit No. 6 (NAMRU-6), in collaboration with the Peruvian Ministry of Health, has conducted clinic-based passive surveillance of acute febrile illnesses [...]

Published
2020
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17. Neuroparalytic keratopathy in Stuve-Wiedemann syndrome treated with tarsoconjunctival flap

Author

Hernández-García, Silvia, Valdivia, Hugo, Bartomeu, Joan, and Molina, Jorge

Subjects
Care and treatment, Complications and side effects, Case studies, Paralysis -- Case studies -- Care and treatment, Surgical flaps -- Case studies, Corneal diseases -- Case studies -- Care and treatment, Eye surgery -- Case studies, Osteochondrodysplasias -- Case studies -- Complications and side effects, Genetic disorders -- Case studies -- Complications and side effects, Flaps (Surgery) -- Case studies, Dysplasia -- Case studies -- Complications and side effects, Bone diseases -- Case studies -- Complications and side effects, Eye -- Surgery
Published
2023

19. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon

Author

Cabrera-Sosa, Luis, primary, Nolasco, Oscar, additional, Kattenberg, Johanna H., additional, Fernandez-Miñope, Carlos, additional, Valdivia, Hugo O., additional, Barazorda, Keare, additional, Rios, Silvia Arévalo de los, additional, Rodriguez-Ferrucci, Hugo, additional, Vinetz, Joseph M., additional, Rosanas-Urgell, Anna, additional, geertruyden, Jean-Pierre Van, additional, Gamboa, Dionicia, additional, and Delgado-Ratto, Christopher, additional

Published
2024
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23. Asymptomatic Malaria Reservoirs in Honduras: A Challenge for Elimination.

Author

Banegas, Sharon, Escobar, Denis, Pinto, Alejandra, Moncada, Marcela, Matamoros, Gabriela, Valdivia, Hugo O., Reyes, Allan, and Fontecha, Gustavo

Subjects
RAPID diagnostic tests, MIXED infections, PLASMODIUM vivax, CHARGE exchange, GENETIC markers
Abstract

Background: Efforts on a global scale for combating malaria have achieved substantial progress over the past twenty years. Two Central American nations have accomplished their goal of eliminating malaria: El Salvador and Belize. Honduras has decreased the incidence of malaria and now reports fewer than 4000 malaria cases annually, aspiring to reach elimination by 2030. To accomplish this goal, it is essential to assess the existing strategies employed for malaria control and to address the task of incorporating novel intervention strategies to identify asymptomatic reservoirs. Methods: A survey for detecting asymptomatic cases was carried out in the community of Kaukira, in Gracias a Dios, Honduras, focusing on malaria transmission during 2023. Asymptomatic community members were recruited as participants, malaria screening was performed through a rapid diagnostic test in situ, and a blood sample was collected on filter paper. Highly sensitive molecular assays based on photo-induced electron transfer PCR (PET-PCR) were performed to detect the two species of Plasmodium circulating in Honduras: Plasmodium vivax and Plasmodium falciparum. In addition, the identification of the parasite species was verified by amplifying three genetic markers (Pvmsp3α, Pvmsp3ß, and Pfmsp1). Results: A total of 138 participants were recruited, mostly adult women. All individuals tested negative on the rapid diagnostic test. Positive results for malaria were detected by PET-PCR in 17 samples (12.3%). Most samples (12 out of 17) were amplified with a Ct value between 37 and 42, indicating very low parasitemias. Out of the 17 samples, 16 of them also showed amplification in the species assays. There were nine cases of P. falciparum infections and seven cases of P. vivax infections that were further confirmed by nested PCR (nPCR) of Pvmsp3 and Pfmsp1. Parasitemias ranged from 100 p/μL to less than 0.25 p/μL. One sample showed mixed infection. Conclusions: The existence of asymptomatic malaria reservoirs in Honduras can contribute to disease transmission and pose a challenge that may hinder elimination efforts, requiring public health authorities to modify surveillance strategies to identify the disease and treat this population accordingly. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Multitemporal analysis of forest cover using spatial remote sensing and GIS methodology in the Coroico River sub-basin-Caranavi Province in the years 1989-2014

Author

Condori-Luna Ismael Junior, Loza-Murguia Manuel Gregorio, Mamani-Pati Francisco, and Solíz-Valdivia Hugo

Subjects
remote sensing, vegetation cover, current land use, sub-basin, caranavi, geographic information system, deforestation., Science, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract

Remote sensing is a technique used for the acquisition of information (in this case the situation of the forests) by means of spatial images obtained by satellite (distant sensors). Later, different techniques of digital and visual processing are used in the satellite images (multispectral type Landsat), to determine the changes in the vegetal cover of the soil for the periods of 1989-2005 and 2005-2014. The study area is the sub-basin of the Coroico River, which. The methodology of spatial remote sensing and Geographic Information Systems was used to generate deforestation maps and subsequent quantification of this information, which was done through the use of the ArcGIS and ERDAS programs. The digital processing of the images was done to identify areas or areas where none existed, or the vegetation cover was very scarce in the soils for the years 1989, 2005 and 2014. The results obtained were: a progressive decrease of the forested areas, being more severe in the period 1989-2005 in contrast to the period 2005-2014. With the results obtained, it is concluded that the loss of the forest is mainly due to inadequate production techniques (agriculture), which leads to the migration and habilitation of new agricultural areas in areas where previously they were forest. This process that is increasing over time occurs at altitudes ranging from 574 to 1605 meters above sea level in the sub-basin, the deforested area has increased 3 times more from 602.05 to 1705.05 ha with a deforestation rate of 59.38 ha Annual forest losses during the period from 1989 to 2005 in relation to the period from 2005 to 2014 that reaches 16.99 ha. Based on the linear data trend, these forest areas will continue to increase in the coming years.

Published
2018
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30. Malaria Molecular Surveillance in the Peruvian Amazon with a Novel Highly Multiplexed Plasmodium falciparum AmpliSeq Assay

Author

Kattenberg, Johanna Helena, primary, Fernandez-Miñope, Carlos, additional, van Dijk, Norbert J., additional, Llacsahuanga Allcca, Lidia, additional, Guetens, Pieter, additional, Valdivia, Hugo O., additional, Van geertruyden, Jean-Pierre, additional, Rovira-Vallbona, Eduard, additional, Monsieurs, Pieter, additional, Delgado-Ratto, Christopher, additional, Gamboa, Dionicia, additional, and Rosanas-Urgell, Anna, additional

Published
2023
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31. Correction: Diversity, distribution and natural Leishmania infection of sand flies from communities along the Interoceanic Highway in the Southeastern Peruvian Amazon

Author

Valdivia, Hugo O., primary, Zorrilla, Victor O., additional, Espada, Liz. J., additional, Perez, Jocelyn G., additional, Razuri, Hugo R., additional, Vera, Hubert, additional, Fernandez, Roberto, additional, Tong, Carlos, additional, Ghersi, Bruno M., additional, Vasquez, Gissella M., additional, Burrus, Roxanne G., additional, Lescano, Andres G., additional, and Montgomery, Joel M., additional

Published
2023
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32. Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU

Author

Reis-Cunha, João Luís, Baptista, Rodrigo P., Rodrigues-Luiz, Gabriela F., Coqueiro-dos-Santos, Anderson, Valdivia, Hugo O., de Almeida, Laila Viana, Cardoso, Mariana Santos, D’Ávila, Daniella Alchaar, Dias, Fernando Hugo Cunha, Fujiwara, Ricardo Toshio, Galvão, Lúcia M. C., Chiari, Egler, Cerqueira, Gustavo Coutinho, and Bartholomeu, Daniella C.

Published
2018
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39. Safety and efficacy of once-daily risdiplam in type 2 and non-ambulant type 3 spinal muscular atrophy (SUNFISH part 2): a phase 3, double-blind, randomised, placebo-controlled trial

Author

Mercuri, Eugenio, primary, Deconinck, Nicolas, additional, Mazzone, Elena S, additional, Nascimento, Andres, additional, Oskoui, Maryam, additional, Saito, Kayoko, additional, Vuillerot, Carole, additional, Baranello, Giovanni, additional, Boespflug-Tanguy, Odile, additional, Goemans, Nathalie, additional, Kirschner, Janbernd, additional, Kostera-Pruszczyk, Anna, additional, Servais, Laurent, additional, Gerber, Marianne, additional, Gorni, Ksenija, additional, Khwaja, Omar, additional, Kletzl, Heidemarie, additional, Scalco, Renata S, additional, Staunton, Hannah, additional, Yeung, Wai Yin, additional, Martin, Carmen, additional, Fontoura, Paulo, additional, Day, John W, additional, Volpe, Joseph J., additional, Posner, John, additional, Kellner, Ulrich, additional, Quinlivan, Rosaline, additional, Daron, Aurore, additional, Delstanche, Stéphanie, additional, Bruninx, Romain, additional, Dal Farra, Fabian, additional, Schneider, Olivier, additional, Balikova, Irina, additional, Delbeke, Patricia, additional, Joniau, Inge, additional, Tahon, Valentine, additional, Wittevrongel, Sylvia, additional, De Vos, Elke, additional, Casteels, Ingele, additional, De Waele, Liesbeth, additional, Cassiman, Catherine, additional, Prové, Lies, additional, Kinoo, David, additional, Vancampenhout, Lisa, additional, Van Den Hauwe, Marleen, additional, Van Impe, Annelies, additional, Prufer de Queiroz Campos Araujo, Alexandra, additional, Chacon Pereira, Aline, additional, Nardes, Flávia, additional, Haefeli, Lorena, additional, Rossetto, Julia, additional, Ferreira Rebel, Marcos, additional, Almeida Pereira, Jaqueline, additional, Campbell, Craig, additional, Sharan, Sapna, additional, McDonald, Wendy, additional, Scholtes, Cheryl, additional, Mah, Jean, additional, Sframeli, Maria, additional, Chiu, Angela, additional, Hagel, Jane, additional, Beneish, Raquel, additional, Cariou-Palmer, Gaela, additional, Pham, Connie, additional, Toffoli, Daniela, additional, Arpin, Stephanie, additional, Turgeon Desilets, Sarah, additional, Wang, Yi, additional, Hu, Chaoping, additional, Huan, Jianfeng, additional, Qian, Chen, additional, Shen, Li, additional, Xiao, Ying, additional, Zhou, Zhenxuan, additional, Li, Hui, additional, Wang, Sujuan, additional, Xiong, Hui, additional, Chang, Xingzhi, additional, Dong, Hui, additional, Liu, Ying, additional, Sang, Tian, additional, Wei, Cuijie, additional, Wen, Jing, additional, Cao, Yiwen, additional, Ly, Xingyao, additional, Zhao, Jingjing, additional, Li, Wenzhu, additional, Qin, Lun, additional, Barisic, Nina, additional, Galiot Delic, Martina, additional, Ivkic, Petra Kristina, additional, Vukojevic, Nenad, additional, Kern, Ivana, additional, Najdanovic, Boris, additional, Skugor, Marin, additional, Gidaro, Teresa, additional, Seferian, Andreea, additional, De Lucia, Silvana, additional, Barreau, Emmanuel, additional, Mnafek, Nabila, additional, Momtchilova, Marta Milkova, additional, Peche, Helene, additional, Valherie, Carole, additional, Grange, Allison, additional, Lilien, Charlotte, additional, Milascevic, Darko, additional, Tachibana, Shotaro, additional, Ravelli, Claudia, additional, Cardas, Ruxandra, additional, Taytard, Jessica, additional, Aubertin, Guillaume, additional, Vanden Brande, Laure, additional, Davion, Jean-Baptiste, additional, Coopman, Stephanie, additional, Bouacha, Ikram, additional, Debruyne, Philippe, additional, Defoort, Sabine, additional, Derlyn, Gilles, additional, Leroy, Florian, additional, Danjoux, Loïc, additional, Guilbaud, Julie, additional, Desguerre, Isabelle, additional, Barnérias, Christine, additional, Semeraro, Michaela, additional, Bremond-Gignac, Dominique, additional, Bruere, Lenaic, additional, Rateaux, Maxence, additional, Deladrière, Élodie, additional, Germa, Virginie, additional, Pereon, Yann, additional, Mercie, Sandra, additional, Billaud, Fanny, additional, Le Goff, Lucie, additional, Letellier, Guy, additional, Portefaix, Aurélie, additional, De-Montferrand, Camille, additional, Le-Goff, Laure, additional, Fontaine, Stephanie, additional, Saidi, Manel, additional, Bouzid, Nabil, additional, Barriere, Aurélie, additional, Tinat, Marie, additional, Dreesbach, Michelle, additional, Lagréze, Wolf, additional, Michaelis, Bettina, additional, Molnar, Fanni, additional, Seger, Dorina, additional, Vogt, Sibylle, additional, Bertini, Enrico, additional, D'Amico, Adele, additional, Petroni, Sergio, additional, Bonetti, Anna Maria, additional, Carlesi, Adelina, additional, Mizzoni, Irene, additional, Bruno, Claudio, additional, Priolo, Enrico, additional, Rao, Giuseppe, additional, Morando, Simone, additional, Tacchetti, Paola, additional, Zuffi, Ambra, additional, Comi, Giacomo Pietro, additional, Brusa, Roberta, additional, Corti, Stefania, additional, Daniele, Velardo, additional, Govoni, Alessandra, additional, Magri, Francesca, additional, Minorini, Valeria, additional, Osnaghi, Silvia Gabriella, additional, Abbati, Francesca, additional, Fassini, Federica, additional, Foa, Michaela, additional, Lopopolo, Amaqlia, additional, Meneri, Megi, additional, Zoppas, Francesca, additional, Parente, Valeria, additional, Masson, Riccardo, additional, Bianchi Marzoli, Stefania, additional, Santarsiero, Diletta, additional, Garcia Sierra, Myriam, additional, Tremolada, Gemma, additional, Arnoldi, Maria Teresa, additional, Vigano, Marta, additional, Zanin, Riccardo, additional, Mercuri, Eugenio, additional, Antonaci, Laura, additional, de Sanctis, Roberto, additional, Pane, Marika, additional, Pera, Maria Carmela, additional, Amorelli, Giulia Maria, additional, Barresi, Costanza, additional, D'Amico, Gugliemo, additional, Orazi, Lorenzo, additional, Coratti, Giorgia, additional, Haginoya, Kazuhiro, additional, Kato, Atsuko, additional, Morishita, Yuko, additional, Kira, Ryutaro, additional, Akiyama, Kiyomu, additional, Goto, Miwako, additional, Mori, Yujiro, additional, Okamoto, Misato, additional, Tsutsui, Saki, additional, Takatsuji, Yuta, additional, Tanaka, Aya, additional, Komaki, Hirofumi, additional, Omori, Miina, additional, Suzuki, Ippei, additional, Takeuchi, Mizuki, additional, Todoroki, Daisuke, additional, Watanabe, Seji, additional, Matsubayashi, Tomoko, additional, Inakazu, Emi, additional, Nagura, Hiroe, additional, Suzuki, Akira, additional, Usui, Manami, additional, Ishikawa, Nobutsune, additional, Harada, Yousuke, additional, Fudeyasu, Kenishi, additional, Hirata, Kazuhiko, additional, Michiue, Kana, additional, Ueda, Kazuyuki, additional, Fujitani, Junko, additional, Arakawa, Reiko, additional, Takano, Kozue, additional, Yashiro, Shigeko, additional, Seki, Maiko, additional, Sano, Nozomi, additional, Fukuyama, Koji, additional, Matsumoto, Yuki, additional, Miyazaki, Hirofumi, additional, Shibata, Minoru, additional, Kobayashi, Kyoko, additional, Nakamura, Yukie, additional, Takeshima, Yasuhiro, additional, Kuma, Moe, additional, Fraczek, Anna, additional, Jedrzejowska, Maria, additional, Lusakowska, Anna, additional, Czeszyk-Piotrowicz, Agnieszka, additional, Hautz, Wojciech, additional, Rakusiewicz, Klaudia, additional, Burlewicz, Malgorzata, additional, Gierlak-Wojcicka, Zuzanna, additional, Kepa, Malwina, additional, Sikorski, Adam, additional, Sobieraj, Marcin, additional, Mazurkiewicz-Beldzinska, Maria, additional, Lemska, Anna, additional, Modrzejewska, Sandra, additional, Koberda, Mateusz, additional, Stodolska-Koberda, Urszula, additional, Waskowska, Agnieszka, additional, Kolendo, Jagoda, additional, Sobierajska-Rek, Agnieszka, additional, Steinborn, Barbara, additional, Dalz, Magdalena, additional, Grabowska, Julia, additional, Hajduk, Wojciech, additional, Janasiewicz-Karachitos, Justyna, additional, Klimas, Monika, additional, Stopa, Marcin, additional, Gajewska, Ewa, additional, Pusz, Beata, additional, Vlodavets, Dmitry, additional, Melnik, Evgenia, additional, Leppenen, Natalya, additional, Yupatova, Nataliya, additional, Monakhova, Anastasya, additional, Papina, Yulia, additional, Shidlovsckaia, Olga, additional, Milic Rasic, Vedrana, additional, Brankovic, Vesna, additional, Kosac, Ana, additional, Djokic, Olivera, additional, Jakšic, Vesna, additional, Pepic, Ana, additional, Martinovic, Jelena, additional, Munell Casadesus, Francina, additional, Tizzano, Eduardo, additional, Martín Begué, Nieves, additional, Wolley Dod, Charlotte, additional, Subira, Olaia, additional, Planas Pascual, Bernat, additional, Toro Tamargo, Esther, additional, Madruga Garrido, Marcos, additional, Medina Romero, José David, additional, Salinas, Marta Peña, additional, Nascimento Osorio, Andrés, additional, Díaz Cortés, Ana, additional, Jiménez Gañan, Enrique, additional, Suh, Simone Dowon, additional, Medina Cantillo, Julita, additional, Moya, Obdulia, additional, Padros, Nuria, additional, Urraca, Sandra Roca, additional, Valdivia, Hugo Gonzalez, additional, Pascual Pascual, Samuel, additional, de Manuel, Sofía, additional, Martin, Susana Noval, additional, Burnham, Paul, additional, Espinosa, Sandra, additional, Moreno, Mercedes Martinez, additional, Topaloglu, Haluk, additional, Oncel, Ibrahim, additional, Eroglu Ertugru, Nesibe, additional, Konuskan, Bahadir, additional, Eldem, Bora, additional, Kadayifçilar, Sibel, additional, Alemdaroglu, Ipek, additional, Karaduman, Aynur Ayse, additional, Yilmaz, Oznur Tunca, additional, Bilgin, Neslihan, additional, Sari, Seher, additional, Chiriboga, Claudia, additional, Lee, John J., additional, Rome-Martin, Donnielle, additional, Day, John W., additional, Beres, Shannon, additional, Duong, Tina, additional, Gee, Richard, additional, Dunaway Young, Sally, additional, Fuerst-Recktenwald, Sabine, additional, Marquet, Anne, additional, Muelhardt, Nicoletta, additional, and Trundell, Dylan, additional

Published
2022
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40. Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum Ampliseq assay

Author

Kattenberg, Johanna Helena, primary, Fernandez-Miñope, Carlos, additional, van Dijk, Norbert J., additional, Llacsahuanga Allcca, Lidia, additional, Guetens, Pieter, additional, Valdivia, Hugo O., additional, Van geertruyden, Jean-Pierre, additional, Rovira-Vallbona, Eduard, additional, Monsieurs, Pieter, additional, Delgado-Ratto, Christopher, additional, Gamboa, Dionicia, additional, and Rosanas-Urgell, Anna, additional

Published
2021
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42. Validation study of Boil & Spin Malachite Green Loop Mediated Isothermal Amplification (B&S MG-LAMP) versus microscopy for malaria detection in the Peruvian Amazon

Author

Barazorda, Keare A., primary, Salas, Carola J., additional, Braga, Greys, additional, Ricopa, Leonila, additional, Ampuero, Julia S., additional, Siles, Crystyan, additional, Sanchez, Juan F., additional, Montano, Silvia, additional, Lizewski, Stephen E., additional, Joya, Christie A., additional, Bishop, Danett K., additional, and Valdivia, Hugo O., additional

Published
2021
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44. Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

Author

Cardenas, Jenny C., primary, Giraldo-Parra, Sandra Y., additional, Gonzalez, Maria U., additional, Gutierrez-Silva, Lady Y., additional, Jaimes-Villamizar, Lucy, additional, Roa-Parra, Alba L., additional, Carvajal, Daisy J., additional, Valdivia, Hugo O., additional, Sanchez, Juan F., additional, Colpitts, Tonya M., additional, and Londono-Renteria, Berlin, additional

Published
2021
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45. Comparison of sand fly trapping approaches for vector surveillance of Leishmania and Bartonella species in ecologically distinct, endemic regions of Peru

Author

Zorrilla, Victor O., primary, Lozano, Marisa E., additional, Espada, Liz J., additional, Kosoy, Michael, additional, McKee, Clifton, additional, Valdivia, Hugo O., additional, Arevalo, Heriberto, additional, Troyes, Mario, additional, Stoops, Craig A., additional, Fisher, Michael L., additional, and Vásquez, Gissella M., additional

Published
2021
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47. Diversity, distribution and natural Leishmania infection of sand flies from communities along the Interoceanic Highway in the Southeastern Peruvian Amazon

Author

Valdivia, Hugo O., primary, Zorrilla, Victor O., additional, Espada, Liz. J., additional, Perez, Jocelyn G., additional, Razuri, Hugo R., additional, Vera, Hubert, additional, Fernandez, Roberto, additional, Tong, Carlos, additional, Ghersi, Bruno M., additional, Vasquez, Gissella M., additional, Burrus, Roxanne G., additional, Lescano, Andres G., additional, and Montgomery, Joel M., additional

Published
2021
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48. Antibody Responses Against Anopheles darlingi Immunogenic Peptides in Plasmodium Infected Humans

Author

Londono-Renteria, Berlin, primary, Montiel, Jehidys, additional, Calvo, Eric, additional, Tobón-Castaño, Alberto, additional, Valdivia, Hugo O., additional, Escobedo-Vargas, Karin, additional, Romero, Luz, additional, Bosantes, Maria, additional, Fisher, Michael L., additional, Conway, Michael J., additional, Vásquez, Gissella M., additional, and Lenhart, Audrey E., additional

Published
2020
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