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1. Serum Levels of IL-1 RA Increase with Obesity and Type 2 Diabetes in Relation to Adipose Tissue Dysfunction and are Reduced After Bariatric Surgery in Parallel to Adiposity

Author

Frühbeck G, Catalán V, Ramírez B, Valentí V, Becerril S, Rodríguez A, Moncada R, Baixauli J, Silva C, Escalada J, and Gómez-Ambrosi J

Subjects
il-1ra, obesity, type 2 diabetes, inflammation, adipose tissue, adipokines, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Gema Frühbeck,1– 4 Victoria Catalán,1– 3 Beatriz Ramírez,1– 3 Víctor Valentí,2,3,5 Sara Becerril,1– 3 Amaia Rodríguez,1– 3 Rafael Moncada,2,3,6 Jorge Baixauli,5 Camilo Silva,2– 4 Javier Escalada,2,4 Javier Gómez-Ambrosi1– 3 1Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain; 2Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain; 3Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain; 4Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pamplona, Spain; 5Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain; 6Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, SpainCorrespondence: Javier Gómez-Ambrosi, Metabolic Research Laboratory, Clínica Universidad de Navarra, Irunlarrea 1, Pamplona, 31008, Spain, Tel +34 948 425600 (ext. 806567), Email jagomez@unav.esBackground: Excess adiposity leads to a dysfunctional adipose tissue that contributes to the development of obesity-associated comorbidities such as type 2 diabetes (T2D). Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring antagonist of the IL-1 receptor with anti-inflammatory properties. The aim of the present study was to compare the circulating concentrations of IL-1RA and its mRNA expression in visceral adipose tissue (VAT) in subjects with normal weight (NW), obesity with normoglycemia (OB-NG), or obesity with impaired glucose tolerance or T2D (OB-IGT&T2D) and to analyze the effect of changes in body fat percentage (BF%) on IL-1RA levels.Methods: Serum concentrations of IL-1RA were measured in 156 volunteers. Expression of IL1RN mRNA in VAT obtained from 36 individuals was determined. In addition, the concentrations of IL-1RA were measured before and after weight gain as well as weight loss following a dietetic program or Roux-en-Y gastric bypass (RYGB).Results: Serum levels of IL-1RA were significantly increased in individuals with obesity, being further increased in the OB-IGT&T2D group (NW 440 ± 316, OB-NG 899 ± 562, OB-IGT&T2D 1265 ± 739 pg/mL; P< 0.001) and associated with markers of inflammation and fatty liver. IL1RN mRNA expression in VAT was significantly increased in the OB-IGT&T2D group and correlated in the global cohort with the mRNA expression of SPP1, CCL2, CD68, and MMP9. Levels of IL-1RA were not modified after modest changes in BF%, but RYGB-induced weight loss significantly decreased IL-1RA concentrations from 1233 ± 1009 to 660 ± 538 pg/mL (P< 0.001).Conclusion: Serum IL-1RA concentrations are increased in patients with obesity being further elevated in obesity-associated IGT and T2D in association with markers of adipose tissue dysfunction. The mRNA expression of IL1RN is markedly increased in VAT of subjects with obesity and T2D in relation with genes involved in macrophage recruitment, inflammation and matrix remodeling. Serum IL-1RA concentrations are reduced when a notable amount of BF% is loss. Measurement of IL-1RA is an excellent biomarker of adipose tissue dysfunction in obesity-associated metabolic alterations.Keywords: IL-1RA, obesity, type 2 diabetes, inflammation, adipose tissue, adipokines

Published
2022

2. The Differential Expression of the Inflammasomes in Adipose Tissue and Colon Influences the Development of Colon Cancer in a Context of Obesity by Regulating Intestinal Inflammation

Author

Frühbeck G, Mentxaka A, Ahechu P, Gómez-Ambrosi J, Ramírez B, Becerril S, Rodríguez A, Unamuno X, Cienfuegos JA, Casado M, Burrell MA, Martín M, Baixauli J, Valentí V, Moncada R, Reina G, Silva C, and Catalán V

Subjects
inflammasome, nlrp, inflammation, colon cancer, obesity, adipose tissue, akkermansia muciniphila, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Gema Frühbeck,1– 4,&ast; Amaia Mentxaka,1,2,&ast; Patricia Ahechu,5 Javier Gómez-Ambrosi,1– 3 Beatriz Ramírez,1– 3 Sara Becerril,1– 3 Amaia Rodríguez,1– 3 Xabier Unamuno,1,2,6 Javier A Cienfuegos,5 Marcos Casado,1 María A Burrell,7 Marina Martín,7 Jorge Baixauli,5 Victor Valentí,5 Rafael Moncada,8 Gabriel Reina,9 Camilo Silva,4 Victoria Catalán1– 3 1Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain; 2CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain; 3Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; 4Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pamplona, Spain; 5Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain; 6Medical Engineering Laboratory, Clínica Universidad de Navarra, Pamplona, Spain; 7Department of Histology and Pathology, University of Navarra, Pamplona, Spain; 8Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain; 9Microbiology Laboratory, Clínica Universidad de Navarra, Pamplona, Spain&ast;These authors contributed equally to this workCorrespondence: Gema FrühbeckDepartment of Endocrinology, Clínica Universidad de Navarra, Avda. Pío XII, 36, Pamplona, 31008, SpainTel +34 948 25 54 00 (ext. 4484)Email gfruhbeck@unav.esVictoria CatalánMetabolic Research Laboratory, Clínica Universidad de Navarra, Avda. Pío XII, 36, Pamplona, 31008, SpainTel +34 948 25 54 00 (ext. 5133)Email vcatalan@unav.esBackground: Inflammasomes maintain tissue homeostasis and their altered regulation in the colon, and the adipose tissue (AT) leads to chronic activation of inflammatory pathways promoting colon cancer (CC) development. We aimed to analyze the potential involvement of inflammasomes in obesity-associated CC.Methods: Ninety-nine volunteers [61 with obesity (OB) and 38 normoponderal (NP)] further subclassified according to the approved protocol for the diagnosis of CC (58 without CC and 41 with CC) were included in the case–control study.Results: CC (P< 0.01) and obesity (P< 0.01) were accompanied by increased mRNA levels of NLRP3, NLRP6, ASC, IL1B and NOD2 in VAT. Contrarily, patients with CC exhibited a downregulation of NLRP6 and IL18 in their colon. Additionally, we revealed that the decreased Nlrp1 (P< 0.05), Nlrp3 (P< 0.01) and Nlrp6 (P< 0.01) mRNA levels in the colon from obese rats significantly increase (P< 0.05) after caloric restriction. Adipocyte-conditioned media obtained from subjects with obesity reduced (P< 0.01) the mRNA of NLRP3 as well as molecules involved in maintaining the intestinal integrity (MUC2, CLDN1 and TJP1) and the anti-inflammatory factors FGF21, KLF4, and IL33 and in HT-29 cells. We also found that the knockdown of NLRP6 in HT-29 cells significantly upregulated (P< 0.05) the mRNA of NLRP1 and NLRP3 and inhibited (P< 0.05) the expression levels of MUC2. Finally, we showed that the incubation of HT-29 with Akkermansia muciniphila influence (P< 0.05) the inflammasome expression profile as well as intestinal integrity-related genes and aberrant inflammation.Conclusions: These findings provide evidence that the downregulated levels of NLRP6 and IL18 in the colon from patients with CC may be responsible for a reduced intestinal-barrier integrity, triggering local inflammation, which in turn acts on the dysfunctional AT in obesity, increasing the expression of different inflammasome components and flaring up a vicious cycle of uncontrollable inflammatory cascades that favours a pro-tumorigenic microenvironment.Keywords: inflammasome, NLRP, inflammation, colon cancer, obesity, adipose tissue, Akkermansia muciniphila

Published
2021

3. The Differential Expression of the Inflammasomes in Adipose Tissue and Colon Influences the Development of Colon Cancer in a Context of Obesity by Regulating Intestinal Inflammation [Corrigendum]

Author

Frühbeck G, Mentxaka A, Ahechu P, Gómez-Ambrosi J, Ramírez B, Becerril S, Rodríguez A, Unamuno X, Cienfuegos JA, Casado M, Burrell MA, Martín M, Baixauli J, Valentí V, Moncada R, Reina G, Silva C, and Catalán V

Subjects
inflammasome, nlrp, inflammation, colon cancer, obesity, adipose tissue, akkermansia muciniphila, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Frühbeck G, Mentxaka A, Ahechu P, et al. J Inflamm Res. 2021;14:6431-6446. The authors advise that the funding section on page 6444 is incorrect. The funding statement should read as follows: Funding This study was funded by Plan Estatal I+D+I from the Spanish Instituto de Salud Carlos III–Subdirección General de Evaluación y Fomento de la investigación–FEDER (grant numbers PI19/00785, PI20/00080 and PI20/00927), Gobierno de Navarra–FEDER (10/2018) and by CIBEROBN, ISCIII, Spain. Funding sources had no role in manuscript writing or the decision to submit the manuscript for publication. The authors apologize for this error.

Published
2023

7. Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment

Author

Lozano, A., Marruecos, J., Rubió, J., Farré, N., Gómez-Millán, J., Morera, R., Planas, I., Lanzuela, M., Vázquez-Masedo, M. G., Cascallar, L., Giralt, J., Escames, G., Valentí, V., Grima, P., Bosser, R., Tarragó, C., and Mesía, R.

Published
2021
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14. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings

Author

Andel, J., Balcke, P., Benedicic, B., Eisterer, W., Fridrik, M., Jagdt, B., Keil, F., Kretschmer, A., Krippl, P., Oexle, H., Pecherstorfer, M., Samonigg, H., Schmid, M., Thaler, J., Tinchon, C., Weiss, H., Arts, J., De Man, M., Demolin, G., Janssens, J., Polus, M., Benczikova, B., Melichar, B., Prausova, J., Vitek, P., Andersen, F.Z., Jensen, B.B., Keldsen, N., Østerlind, K., Vistisen, K., Elme, A., Magi, A., Ojamaa, K., Ristamäki, R., Salminen, T., Ben Abdelghani, M., Bouche, O., Borg, C., Bouhier-Leporrier, K., Breysacher, G., Chone, L., Clavero Fabri, M.-C., Deplanque, G., Desseigne, F., Dourthe, L.-M., Ezenfis, J., Faroux, R., François, E., Garnier, C., Gaspard, M.-H., Hebbar, M., Illory, J.F., Kaminsky, M.-C., Lecomte, T., Legoux, J.-L., Levache, B., Lobry, C., Lotz, J.-P., Mabro, M., Manet-Lacombe, S., Manfredi, S., Matysiak Budnik, T., Miglianico, L., Mineur, L., Moullet, I., Naman, H., Nouyrigat, P., Oziel-Taieb, S., Perrier, H., Pezet, D., Philip, J., Pottier, V., Porneuf, M., Ramdani, M., Re, D., Rinaldi, Y., Spaeth, D., Taieb, J., Terrebonne, E., Texereau, P., Thirot Bidault, A., Tournigand, C., Tubiana-Mathieu, N., Vantelon, J.-M., Viret, F., Ychou, M., Bangerter, M., Bertram, M.E., Bohnsteen, B., Brinkmann, L., Caca, K., Constantin, C., Cordes, H.-J., Dietrich, G., Eggert, J., Engel, E., Fahlke, J., Fensterer, H., Florschütz, A., Folprecht, G., Forstbauer, H., Freier, W., Freund, M., Frickhofen, N., Gäbele, E., Geißler, M., Gieseler, F., Göhler, T., Graeven, U., Groschek, M., Grundeis, M., Hacker, U., Hagen, V., Hebart, H.F., Hegewisch-Becker, S., Heike, M., Herrmann, T., Hildebrandt, B., Höffkes, H.-G., Hübner, G., Hübner, J., Kettner, E., Kneba, M., Kohnke, J.W., Kojouharoff, G., König, C., Kretzschmar, A., Kröning, H., Kürner, K., Lammert, F., Lerchenmüller, C., Lück, A., Meiler, J., Mergenthaler, H.-G., Müller, L., Müller-Naendrup, C., Nusch, A., Papke, J., Porschen, R., Rädle, J., Reddemann, C., Ridwelski, K., Riera-Knorrenschild, J., Rudi, J., Schmalenberger, A., Schimanski, C.-C., Schlegel, F., Schlichting, C., Schmidt, P., Schmiegel, W., Schmitz, S., Schulze-Bergkamen, H., Schwaner, I., Schwarzer, A., Schwerdtfeger, M., Selbach, J., Sieber, M., Siebler, J., Staib, P., Stauch, M., Steffens, C.-C., Stübs, P., Tischendorf, J., Trarbach, T., Tummes, D., Valdix, A.-R., Vogel, A., Von Wichert, G.P.L., Walther, M., Welslau, W., Wilhelm, G., Wobster, H., Wolf, T., Zeigenhagen, N., Zomorodbaksch, B., Batman, E., Bloemendal, H.J., Kehrer, D.F.S., Guren, T., Indrebø, G., Kersten, C., Soerbye, H., Fragoso, M., Fragoso, R., Mellidez, J.C., Sa, A., Aljobran, A., Darwish, T., Alonso-Orduna, V., Aparicio, J., Aranda, E., Bosch, C., Galan-Brotons, A., Busquier Hernandez, I., Camara, J.C., Campos Cervera, J.M., Carlos Garcia Giron, C., Del Prado, P.M., Donnay, O., Escudero, P., Falco, E., Gallego Plazas, J., Garcia Alfonso, P., Gonzalez Flores, E., Gravalos, C., Guardeno, R., Juárez, A., Lopez Ladron, A., Losa Gaspa, F., MªVicent Vergé, J., Marcuello Gaspar, E., Massuti Sureda, B., Molina, J., Montero, I.C., Muñoa, A.L., Naranjo, M.B., Oruezabal Moreno, M.J., Pachón Olmos, V., Pericay, C., Reina Zoilo, J.J., Rivera, F., Ruiz Casado, A., Safont, M.J., Salud Salvia, A., Tobena, M., Toral, J.C., Valenti, V., Valladares Ayerbes, M., Vieitez, J.M., Vera, R., Berglund, A., Fernebro, E., Hess-Umbricht, V., Pless, M., Popescu, R., Winterhalder, R., Kubicka, S., Greil, R., André, T., Bennouna, J., Sastre, J., Van Cutsem, E., von Moos, R., Österlund, P., Reyes-Rivera, I., Müller, T., Makrutzki, M., and Arnold, D.

Published
2013
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16. LBA45 Randomized open label phase III study comparing the efficacy and safety of everolimus followed by chemotherapy (CT) with streptozotocin (STZ)-5FU upon progression or the reverse sequence, in advanced progressive panNETs: The SEQTOR study (GETNE 1206)

Author

Salazar, R., primary, Tafuto, S., additional, Krogh, M., additional, Teule, A., additional, Garcia-Carbonero, R., additional, Klumpen, H.J., additional, Cremer, B., additional, Sevilla, I., additional, Eriksson, B., additional, Tabaksblat, E., additional, Metges, J-P., additional, Reed, N.S., additional, Schrader, J., additional, Navarro, V., additional, Valentí, V., additional, Hernando, J., additional, Colao, A.M., additional, Vestermark, L., additional, Carnaghi, C., additional, and Capdevila, J., additional

Published
2022
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25. Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

Author

Abou-Mrad-Fricquegnon, A, Alasfur, A, Alexandrou, A, Barbosa, A, Bashir, A, Bosco, A, Charalabopoulos, A, Curell, A, Davarpanah Jazi, A, Diego, A, Elghandour, A, Ergin, A, Garcia, A, Ghazal, A, Haddad, A, Ibarzábal, A, Khazraji, A, Lale, A, Lázaro, A, Leyva-Alvizo, A, Liagre, A, Maleckas, A, Osman, A, Pantelis, A, Pazouki, A, Plamper, A, Raziel, A, Rizzi, A, Sanchez, A, Sharma, A, Spaventa, A, Sumer, A, Torres, A, Türkçapar, A, Ugale, A, Velikorechin, A, Vitiello, A, Alkhaffaf, B, Bomans, B, Ammori, BJ, Pares, B, Smeu, B, Zilberstein, B, Boeker, C, Brodén, C, Copaescu, C, Guevara, C, Güldoğan, C, Kirkil, C, Matthys, C, Nagliati, C, Parmar, C, Trindade, C, Vaz, C, Wietzycoski, C, Zerrweck, C, Bedi, D, de Marchi, D, Faraj, D, Foschi, D, Goitein, D, Hazzan, D, Lapatsanis, D, Mazza, D, Mohammed, D, Padilla-Armendariz, D, Pennisi, D, Pham, D, Pournaras, D, Swank, D, Thakkar, D, Baena, E, Baili, E, Bastos, E, Dilektasli, E, Hazebroek, E, Kaplan, E, Lopes, E, Manno, E, Pinotti, E, Sdralis, E, Barrera-Rodriguez, F, Cantu, F, Jr., Frattini, F, Martini, F, Berardi, G, Cesana, G, Dapri, G, Dinescu, G, Juglard, G, Martinez de Aragon, G, Menaldi, G, Ören, G, Pavone, G, Rana, G, Vrakopoulou, G, Aboshanab, H, Al-Momani, H, Balamoun, H, Çiyiltepe, H, de Vasconcelos Cunha, H, Elghadban, H, Gislason, H, Hamed, H, Heneghan, H, Ibrahim, H, Melali, H, Reyes, H, Sebbag, H, Hakami, I, Hutopila, I, Balibrea, J, Bernardo, J, Campos, J, Chevallier, J, Dargent, J, Estrada, J, Gonzalez, J, Hewes, J, Himpens, J, Mall, J, Monterrubio, J, Pasquier, J, Albanopoulos, K, Bartosiak, K, Kaseja, K, Kumar, K, Rheinwalt, K, Shah, K, van de Pas, K., Angrisani, L, Benuzzi, L, Chong, L, Layani, L, Lee, L, Level, L, Taylor, L, Zinai, L, Akbaba, M, Alejandro, M, Altarawni, M, Beisani, M, Bertrand, M, Cantu, M, Dincer, M, Elbanna, M, Elfawal, M, Focquet, M, Forero, M, Hadad, M, Hii, M, Iovino, M, Islam, M, Josa, M, Kaplan, M, Kermansaravi, M, Khaitan, M, Kizilkaya, M, Kotowski, M, Montouri, M, Musella, M, Narwaria, M, Navarro, M, Niazi, M, Özmen, M, Qassem, M, Romeijn, M, Said, M, Salman, M, Solovyeva, M, Takieddine, M, Uccelli, M, Ustun, M, Valeti, M, Walędziak, M, Arora, N, Dukkipati, N, Fearon, N, Kiran, N, Paleari, N, Sakran, N, Silva, N, Tartaglia, N, Savas, O, Şen, O, Viveiros, O, Fabbri, P, García, P, Major, P, Martinez, P, Martinez Duartez, P, Salminen, P, Shah, P, Gadani, R, Gokay, R, Gudaityte, R, Kassir, R, Liem, R, Mohan, R, Palma, R, Quinino, R, Ribeiro, R, Vilallonga, R, Arana-Garza, S, Chiappetta, S, Davakis, S, Ghareeb, S, Gregorio, S, Khaldi, S, Martinez, S, Okkema, S, Olmi, S, Ortiz, S, Pinango, S, Shah, S, Shahabi, S, Taha, S, Ugale, S, Barreiro, T, Beck, T, Poghosyan, T, Samarkandy, T, Yigit, T, Borrelli, V, Bottino, V, Marco, V, Ormando, V, Pol, V, Sierra Esteban, V, Valentí, V, Leclercq, W, Souza, W, Vening, W, Vleeschouwers, W, van der Burgh, Y, Singhal, Rishi, Tahrani, Abd A, Ludwig, Christian, and Mahawar, Kamal

Published
2021
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27. Comparison of phenotypes and outcomes following resection of incidental versus symptomatic pancreatic neuroendocrine tumors

Author

Hurtado-Pardo L, Breeze CE, Cienfuegos JA, Benito A, Valentí V, Martí-Cruchaga P, Zozaya G, Martínez Regueira F, Pardo F, and Rotellar Sastre F

Abstract

Background/Aim Fifty to 70 percent of pancreatic neuroendocrine tumors are diagnosed incidentally. The objective of this study is to compare the phenotype and oncological outcomes of incidental versus symptomatic pancreatic neuroendocrine tumors. Methods A retrospective study was conducted identifying all incidental and symptomatic tumors resected between 2000 and 2019. Baseline characteristics, symptoms, operative variables and pathological stage were all recorded. In both groups, patterns of recurrence and overall and disease-free survival were analyzed. Results Fifty-one incidental and 45 symptomatic pancreatic tumor resections were performed. Symptomatic tumors were more frequent in women (29 vs 17; p=0.005), in younger patients (median years; 50 vs 58; p=0.012) and were detected at a more advanced stage (p=0.027). There were no differences in location and most resections (n= 49; 51%) were performed laparoscopically. There were no operative mortalities and 17 (17.7%) severe complications (=IIIb on the Clavien-Dindo classification) were recorded with no differences between the two groups. With a median follow-up of 64.4 months (range 13.5 - 90), overall survival at 5 and 10 years was 89.7% and 72.8% for the non-incidental tumors, and 80.9% and 54.6% for the incidental tumors (p=ns). Disease-free survival in both groups (excluding M1a) was 71.2% and 47.5%, and 93.7% and 78.1%, respectively (p= ns). Conclusions Symptomatic tumors are more frequent in women and present at higher pathological stages. There were no significant differences in overall and disease-free survival between the two groups. Resection of incidental tumors =1.5 - 2 cm seems advisable, although each case should assessed on an individual basis.

Published
2021

33. Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

Author

Singhal, Rishi, primary, Tahrani, Abd A, additional, Ludwig, Christian, additional, Mahawar, Kamal, additional, Abou-Mrad-Fricquegnon, A, additional, Alasfur, A, additional, Alexandrou, A, additional, Barbosa, A, additional, Bashir, A, additional, Bosco, A, additional, Charalabopoulos, A, additional, Curell, A, additional, Davarpanah Jazi, A, additional, Diego, A, additional, Elghandour, A, additional, Ergin, A, additional, Garcia, A, additional, Ghazal, A, additional, Haddad, A, additional, Ibarzábal, A, additional, Khazraji, A, additional, Lale, A, additional, Lázaro, A, additional, Leyva-Alvizo, A, additional, Liagre, A, additional, Maleckas, A, additional, Osman, A, additional, Pantelis, A, additional, Pazouki, A, additional, Plamper, A, additional, Raziel, A, additional, Rizzi, A, additional, Sanchez, A, additional, Sharma, A, additional, Spaventa, A, additional, Sumer, A, additional, Torres, A, additional, Türkçapar, A, additional, Ugale, A, additional, Velikorechin, A, additional, Vitiello, A, additional, Alkhaffaf, B, additional, Bomans, B, additional, Ammori, BJ, additional, Pares, B, additional, Smeu, B, additional, Zilberstein, B, additional, Boeker, C, additional, Brodén, C, additional, Copaescu, C, additional, Guevara, C, additional, Güldoğan, C, additional, Kirkil, C, additional, Matthys, C, additional, Nagliati, C, additional, Parmar, C, additional, Trindade, C, additional, Vaz, C, additional, Wietzycoski, C, additional, Zerrweck, C, additional, Bedi, D, additional, de Marchi, D, additional, Faraj, D, additional, Foschi, D, additional, Goitein, D, additional, Hazzan, D, additional, Lapatsanis, D, additional, Mazza, D, additional, Mohammed, D, additional, Padilla-Armendariz, D, additional, Pennisi, D, additional, Pham, D, additional, Pournaras, D, additional, Swank, D, additional, Thakkar, D, additional, Baena, E, additional, Baili, E, additional, Bastos, E, additional, Dilektasli, E, additional, Hazebroek, E, additional, Kaplan, E, additional, Lopes, E, additional, Manno, E, additional, Pinotti, E, additional, Sdralis, E, additional, Barrera-Rodriguez, F, additional, Cantu, F, additional, Frattini, F, additional, Martini, F, additional, Berardi, G, additional, Cesana, G, additional, Dapri, G, additional, Dinescu, G, additional, Juglard, G, additional, Martinez de Aragon, G, additional, Menaldi, G, additional, Ören, G, additional, Pavone, G, additional, Rana, G, additional, Vrakopoulou, G, additional, Aboshanab, H, additional, Al-Momani, H, additional, Balamoun, H, additional, Çiyiltepe, H, additional, de Vasconcelos Cunha, H, additional, Elghadban, H, additional, Gislason, H, additional, Hamed, H, additional, Heneghan, H, additional, Ibrahim, H, additional, Melali, H, additional, Reyes, H, additional, Sebbag, H, additional, Hakami, I, additional, Hutopila, I, additional, Balibrea, J, additional, Bernardo, J, additional, Campos, J, additional, Chevallier, J, additional, Dargent, J, additional, Estrada, J, additional, Gonzalez, J, additional, Hewes, J, additional, Himpens, J, additional, Mall, J, additional, Monterrubio, J, additional, Pasquier, J, additional, Albanopoulos, K, additional, Bartosiak, K, additional, Kaseja, K, additional, Kumar, K, additional, Rheinwalt, K, additional, Shah, K, additional, van de Pas, K., additional, Angrisani, L, additional, Benuzzi, L, additional, Chong, L, additional, Layani, L, additional, Lee, L, additional, Level, L, additional, Taylor, L, additional, Zinai, L, additional, Akbaba, M, additional, Alejandro, M, additional, Altarawni, M, additional, Beisani, M, additional, Bertrand, M, additional, Cantu, M, additional, Dincer, M, additional, Elbanna, M, additional, Elfawal, M, additional, Focquet, M, additional, Forero, M, additional, Hadad, M, additional, Hii, M, additional, Iovino, M, additional, Islam, M, additional, Josa, M, additional, Kaplan, M, additional, Kermansaravi, M, additional, Khaitan, M, additional, Kizilkaya, M, additional, Kotowski, M, additional, Montouri, M, additional, Musella, M, additional, Narwaria, M, additional, Navarro, M, additional, Niazi, M, additional, Özmen, M, additional, Qassem, M, additional, Romeijn, M, additional, Said, M, additional, Salman, M, additional, Solovyeva, M, additional, Takieddine, M, additional, Uccelli, M, additional, Ustun, M, additional, Valeti, M, additional, Walędziak, M, additional, Arora, N, additional, Dukkipati, N, additional, Fearon, N, additional, Kiran, N, additional, Paleari, N, additional, Sakran, N, additional, Silva, N, additional, Tartaglia, N, additional, Savas, O, additional, Şen, O, additional, Viveiros, O, additional, Fabbri, P, additional, García, P, additional, Major, P, additional, Martinez, P, additional, Martinez Duartez, P, additional, Salminen, P, additional, Shah, P, additional, Gadani, R, additional, Gokay, R, additional, Gudaityte, R, additional, Kassir, R, additional, Liem, R, additional, Mohan, R, additional, Palma, R, additional, Quinino, R, additional, Ribeiro, R, additional, Vilallonga, R, additional, Arana-Garza, S, additional, Chiappetta, S, additional, Davakis, S, additional, Ghareeb, S, additional, Gregorio, S, additional, Khaldi, S, additional, Martinez, S, additional, Okkema, S, additional, Olmi, S, additional, Ortiz, S, additional, Pinango, S, additional, Shah, S, additional, Shahabi, S, additional, Taha, S, additional, Ugale, S, additional, Barreiro, T, additional, Beck, T, additional, Poghosyan, T, additional, Samarkandy, T, additional, Yigit, T, additional, Borrelli, V, additional, Bottino, V, additional, Marco, V, additional, Ormando, V, additional, Pol, V, additional, Sierra Esteban, V, additional, Valentí, V, additional, Leclercq, W, additional, Souza, W, additional, Vening, W, additional, Vleeschouwers, W, additional, and van der Burgh, Y, additional

Published
2021
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36. Incidental lesions of the pancreas. A clinicopathological study of 100 cases surgically treated

Author

Hurtado Pardo L, Cienfuegos JA, Antoñanzas J, Valentí V, Benito A, Pardo F, Martínez Regueira F, Zozaya G, Martí-Cruchaga P, Lozano MD, Subtil JC, and Rotellar F

Subjects
Pancreatectomy, Neuroendocrine, genetic structures, Incidental, Outcomes, Cystic tumor, Adenocarcinoma
Abstract

the objective of the present study was to analyze the characteristics of resected incidental lesions of the pancreas.

Published
2020

42. Consistent truncations from the geometry of sphere bundles

Author

Federico Bonetti, Ruben Minasian, Valentí Vall Camell, and Peter Weck

Subjects
Extended Supersymmetry, Supergravity Models, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract In this paper, we present a unified perspective on sphere consistent truncations based on the classical geometric properties of sphere bundles. The backbone of our approach is the global angular form for the sphere. A universal formula for the Kaluza-Klein ansatz of the flux threading the n-sphere captures the full nonabelian isometry group SO(n + 1) and scalar deformations associated to the coset SL(n + 1, ℝ)/SO(n + 1). In all cases, the scalars enter the ansatz in a shift by an exact form. We find that the latter can be completely fixed by imposing mild conditions, motivated by supersymmetry, on the scalar potential arising from dimensional reduction of the higher dimensional theory. We comment on the role of the global angular form in the derivation of the topological couplings of the lower-dimensional theory, and on how this perspective could provide inroads into the study of consistent truncations with less supersymmetry.

Published
2023
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45. Liver mobilization and liver hanging for totally laparoscopic right hepatectomy: an easy way to do it

Author

Fernando Rotellar, Pardo F, Martí-Cruchaga P, Zozaya G, Valentí V, Bellver M, Lopez-Olaondo L, and Hidalgo F

Subjects
Right hepatectomy, Laparoscopic hepatectomy, Laparoscopy, Liver mobilization, right liver
Abstract

The purpose of this study is to describe a technical modification that facilitates right liver mobilization in laparoscopic right hepatectomy (LRH). In the supine position, an inflatable device is placed under the patient's right chest. For right hemiliver mobilization, the table is placed in 30A degrees anti-Trendelenburg and full-left tilt. Balloon inflation offers an additional 30A degrees left inclination that places the patient in an almost left lateral position. Foot and lateral supports are placed to prevent patient slippage during changes in the patient positioning. From December 2013 to October 2015, this technique has been used in 10 consecutive LRH. The indications for these procedures were as follows: four donor hepatectomies for living donor liver transplant, three hepatocellular carcinomas and one peripheral cholangiocarcinoma in cirrhotic patients, one hepatocellular carcinoma in a non-cirrhotic patient, and one case of colorectal cancer metastases. In this period, it has also been used to facilitate mobilization and resection in the posterior segments of the liver in seven patients. In every case, right hemiliver mobilization was easily performed in a maximum time of 15 min and placement of a tape or plastic tube for liver hanging was prepared. We have not observed any complication directly attributable to the technique herein described (i.e. right brachialgia; arms, back or left flank pain) in the early or late postoperative follow-up. The additional left inclination obtained with the inflation of a balloon under the right chest facilitates right hemiliver mobilization. Its use may help in the performance and adoption of LRH.

Published
2017

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