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3. Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial

Author

Perkovic, Vlado, Mahaffey, Kenneth W., Agarwal, Rajiv, Bakris, George, Brenner, Barry M., Cannon, Christopher P., Charytan, David M., de Zeeuw, Dick, Greene, Tom, Jardine, Meg J., Heerspink, Hiddo J.L., Levin, Adeera, Meininger, Gary, Neal, Bruce, Pollock, Carol, Wheeler, David C., Zhang, Hong, Zinman, Bernard, Jardine, Meg, Li, Nicole, Kolesnyk, Inna, Aizenberg, Diego, Pecoits-Filho, Roberto, Cherney, David, Obrador, Gregorio, Chertow, Glenn, Chang, Tara, Hawley, Carmel, Ji, Linong, Wada, Takashi, Jha, Vivekanand, Lim, Soo Kun, Lim-Abrahan, Mary Anne, Santos, Florence, Chae, Dong-Wan, Hwang, Shang-Jyh, Vazelov, Evgueniy, Rychlík, Ivan, Hadjadj, Samy, Krane, Vera, Rosivall, László, De Nicola, Luca, Dreval, Alexander, Nowicki, Michał, Schiller, Adalbert, Distiller, Larry, Górriz, Jose L., Kolesnyk, Mykola, David, Wheeler, C., Guerrero, Rodolfo Andres Ahuad, Albisu, Juan Pablo, Alvarisqueta, Andres, Bartolacci, Ines, Berli, Mario Alberto, Bordonava, Anselmo, Calella, Pedro, Cantero, Maria Cecilia, Cartasegna, Luis Rodolfo, Cercos, Esteban, Coloma, Gabriela Cecilia, Colombo, Hugo, Commendatore, Victor, Cuadrado, Jesus, Cuneo, Carlos Alberto, Cusumano, Ana Maria, Douthat, Walter Guillermo, Dran, Ricardo Dario, Farias, Eduardo, Fernandez, Maria Florencia, Finkelstein, Hernan, Fragale, Guillermo, Fretes, Jose Osvaldo, Garcia, Nestor Horacio, Gastaldi, Anibal, Gelersztein, Elizabeth, Glenny, Jorge Archibaldo, Gonzalez, Joaquin Pablo, Colaso, Patricia del Carmen Gonzalez, Goycoa, Claudia, Greloni, Gustavo Cristian, Guinsburg, Adrian, Hermida, Sonia, Juncos, Luis Isaias, Klyver, Maria Isabel, Kraft, Florencia, Krynski, Fernando, Lanchiotti, Paulina Virginia, Leon de la Fuente, Ricardo Alfonso, Marchetta, Nora, Mele, Pablo, Nicolai, Silvia, Novoa, Pablo Antonio, Orio, Silvia Ines, Otreras, Fabian, Oviedo, Alejandra, Raffaele, Pablo, Resk, Jorge Hector, Rista, Lucas, Papini, Nelson Rodriguez, Sala, Jorgelina, Santos, Juan Carlos, Schiavi, Lilia Beatriz, Sessa, Horacio, Casabella, Tomas Smith, Ulla, Maria Rosa, Valdez, Maria, Vallejos, Augusto, Villarino, Adriana, Visco, Virginia Esther, Wassermann, Alfredo, Zaidman, Cesar Javier, Cheung, Ngai Wah, Droste, Carolyn, Fraser, Ian, Johnson, David, Mah, Peak Mann, Nicholls, Kathy, Packham, David, Proietto, Joseph, Roberts, Anthony, Roger, Simon, Tsang, Venessa, Raduan, Roberto Abrão, Costa, Fernando Augusto Alves da, Amodeo, Celso, Turatti, Luiz Alberto Andreotti, Bregman, Rachel, Sanches, Fernanda Cristina Camelo, Canani, Luis Henrique, Chacra, Antônio Roberto, Borges, João Lindolfo Cunha, Vêncio, Sérgio Alberto Cunha, Franco, Roberto Jorge da Silva, d’Avila, Domingos, Portes, Evandro de Souza, de Souza, Pedro, Deboni, Luciane Mônica, Fraige Filho, Fadlo, Neto, Bruno Geloneze, Gomes, Marcus, Kohara, Suely Keiko, Keitel, Elizete, Saraiva, Jose Francisco Kerr, Lisboa, Hugo Roberto Kurtz, Contieri, Fabiana Loss de Carvalho, Milagres, Rosângela, Junior, Renan Montenegro, de Brito, Claudia Moreira, Hissa, Miguel Nasser, Sabbag, Ângela Regina Nazario, Noronha, Irene, Panarotto, Daniel, Filho, Roberto Pecoits, Pereira, Márcio Antônio, Saporito, Wladmir, Scotton, Antonio Scafuto, Schuch, Tiago, de Almeida, Roberto Simões, Ramos, Cássio Slompo, Felício, João Soares, Thomé, Fernando, Hachmann, Jean Carlo Tibes, Yamada, Sérgio, Hayashida, Cesar Yoiti, Petry, Tarissa Beatrice Zanata, Zanella, Maria Teresa, Andreeva, Viktoria, Angelova, Angelina, Dimitrov, Stefan, Genadieva, Veselka, Genova-Hristova, Gabriela, Hristozov, Kiril, Kamenov, Zdravko, Koundurdjiev, Atanas, Lozanov, Lachezar, Margaritov, Viktor, Nonchev, Boyan, Rangelov, Rangel, Shinkov, Alexander, Temelkova, Margarita, Velichkova, Ekaterina, Yakov, Andrian, Aggarwal, Naresh, Aronson, Ronnie, Bajaj, Harpreet, Chouinard, Guy, Conway, James, Cournoyer, Serge, DaRoza, Gerald, De Serres, Sacha, Dubé, François, Goldenberg, Ronald, Gupta, Anil, Gupta, Milan, Henein, Sam, Khandwala, Hasnain, Leiter, Lawrence, Madore, François, McMahon, Alan, Muirhead, Norman, Pichette, Vincent, Rabasa-Lhoret, Remi, Steele, Andrew, Tangri, Navdeep, Torshizi, Ali, Woo, Vincent, Zalunardo, Nadia, Montenegro, María Alicia Fernández, Gonzalo Godoy Jorquera, Juan, Fariña, Marcelo Medina, Gajardo, Victor Saavedra, Vejar, Margarita, Chen, Nan, Chen, Qinkai, Gan, Shenglian, Kong, Yaozhong, Li, Detian, Li, Wenge, Li, Xuemei, Lin, Hongli, Liu, Jian, Lu, Weiping, Mao, Hong, Ren, Yan, Song, Weihong, Sun, Jiao, Sun, Lin, Tu, Ping, Wang, Guixia, Yang, Jinkui, Yin, Aiping, Yu, Xueqing, Zhao, Minghui, Zheng, Hongguang, Mendoza, Jose Luis Accini, Arcos, Edgar, Avendano, Jorge, Diaz Ruiz, Jorge Ernesto Andres, Ortiz, Luis Hernando Garcia, Gonzalez, Alexander, Triana, Eric Hernandez, Higuera, Juan Diego, Malaver, Natalia, de Salazar, Dora Inés Molina, Rosero, Ricardo, Alexandra Terront Lozano, Monica, Cometa, Luis Valderrama, Valenzuela, Alex, Vargas Alonso, Ruben Dario, Villegas, Ivan, Yupanqui, Hernan, Bartaskova, Dagmar, Barton, Petr, Belobradkova, Jana, Dohnalova, Lenka, Drasnar, Tomas, Ferkl, Richard, Halciakova, Katarina, Klokocnikova, Vera, Kovar, Richard, Lastuvka, Jiri, Lukac, Martin, Pesickova, Satu, Peterka, Karel, Pumprla, Jiri, Rychlik, Ivan, Saudek, Frantisek, Tesar, Vladimir, Valis, Martin, Weiner, Pavel, Zemek, Stanislav, Alamartine, Eric, Borot, Sophie, Cariou, Bertrand, Dussol, Bertrand, Fauvel, Jean-Pierre, Gourdy, Pierre, Klein, Alexandre, Le Meur, Yannick, Penfornis, Alfred, Roussel, Ronan, Saulnier, Pierre-Jean, Thervet, Eric, Zaoui, Philippe, Burst, Volker, Faghih, Markus, Faulmann, Grit, Haller, Hermann, Jerwan-Keim, Reinhold, Maxeiner, Stephan, Paschen, Björn, Plassmann, Georg, Rose, Ludger, Gonzalez Orellana, Ronaldo Arturo, Haase, Franklin Paul, Moreira Diaz, Juan Pablo, Ramirez Roca, Luis Alberto, Sánchez Arenales, Jose Antonio, Sanchez Polo, José Vicente, Juarez, Erick Turcios, Csecsei, Gyongyi, Csiky, Botond, Danos, Peter, Deak, Laszlo, Dudas, Mihaly, Harcsa, Eleonora, Keltai, Katalin, Keresztesi, Sandor, Kiss, Krisztian, Konyves, Laszlo, Major, Lajos, Mileder, Margit, Molnar, Marta, Mucsi, Janos, Oroszlan, Tamas, Ory, Ivan, Paragh, Gyorgy, Peterfai, Eva, Petro, Gizella, Revesz, Katalin, Takacs, Robert, Vangel, Sandor, Vasas, Szilard, Zsom, Marianna, Abraham, Oomman, Bhushan, Raju Sree, Deepak, Dewan, Edwin, Fernando M., Gopalakrishnan, Natarajan, Gracious, Noble, Hansraj, Alva, Jain, Dinesh, Keshavamurthy, C.B., Khullar, Dinesh, Manisha, Sahay, Peringat, Jayameena, Prasad, Narayan, Satyanarayana, Rao K., Sreedhar, Reddy, Sreelatha, Melemadathil, Sudhakar, Bhimavarapu, Chandra Vyasam, Ramesh, Bonadonna, Riccardo, Castellino, Pietro, Ceriello, Antonio, Chiovato, Luca, De Cosmo, Salvatore, Derosa, Giuseppe, Di Carlo, Alberto, Di Cianni, Graziano, Frascà, Giovanni, Fuiano, Giorgio, Gambaro, Giovanni, Garibotto, Giacomo, Giorda, Carlo, Malberti, Fabio, Mandreoli, Marcora, Mannucci, Edoardo, Orsi, Emanuela, Piatti, Piermarco, Santoro, Domenico, Sasso, Ferdinando Carlo, Serviddio, Gaetano, Stella, Andrea, Trevisan, Roberto, Veronelli, Anna Maria, Zanoli, Luca, Akiyama, Hitoshi, Aoki, Hiromi, Asano, Akimichi, Iitsuka, Tadashi, Kajiyama, Shizuo, Kashine, Susumu, Kawada, Toshio, Kodera, Takamoto, Kono, Hiroshi, Koyama, Kazunori, Kumeda, Yasuro, Miyauchi, Shozo, Mizuyama, Kazuyuki, Niiya, Tetsuji, Oishi, Hiroko, Ota, Satoshi, Sakakibara, Terue, Takai, Masahiko, Tomonaga, Osamu, Tsujimoto, Mitsuru, Wakasugi, Masakiyo, Wakida, Yasushi, Watanabe, Takayuki, Yamada, Masayo, Yanagida, Kazuhiro, Yanase, Toshihiko, Yumita, Wataru, Gaupsiene, Egle, Kozloviene, Dalia, Navickas, Antanas, Urbanaviciene, Egle, Abdul Ghani, Rohana, Kadir, Khalid Abdul, Ali, Norsiah, Che Yusof, Mohd Daud, Gan, Chye Lee, Ismail, Mastura, Kong, Wei Yen, Lam, Swee Win, Lee, Li Yuan, Loh, Chek Loong, Manocha, Anita Bhajan, Ng, Kee Sing, Ahmad, Nik Nur Fatnoon Nik, Ratnasingam, Vanassa, Shudim, Saiful Shahrizal Bin, Vengadasalam, Paranthaman, Abraira Munoz, Luis David, Salazar, Melchor Alpizar, Cruz, Juan Baas, Soto, Mario Burgos, Ramos, Jose Chevaile, Wong, Alfredo Chew, Correa Rotter, Jose Ricardo, Escalante, Tonatiu Diaz, Enriquez Sosa, Favio Edmundo, Lozano, Fernando Flores, Flota Cervera, Luis Fernando, Baron, Paul Frenk, Ballesteros, Cecilia Garcia, Gomez Rangel, Jose David, Herrera Jimenez, Luis Enrique, Irizar Santana, Sergio Saul, Flores, Fernando Jimenez, Molina, Hugo Laviada, Luna Ceballos, Rosa Isela, del Campo Blanco, Belia Martin, Franco, Guadalupe Morales, Moreno Loza, Oscar Tarsicio, Rocha, Cynthia Mustieles, Vera, Gregorio Obrador, Castellanos, Ricardo Orozco, Calcaneo, Juan Peralta, Reyes Rosano, Miguel Angel, Pattzi, Hiromi Rodriguez, Guzman, Juan Rosas, Rucker Joerg, Isabel Erika, Saavedra Sanchez, Sandra Berenice, Sanchez Mijangos, Jose Hector, Sanson, Pablo Serrano, Tamayo y Orozco, Juan Alfredo, Chavez, Eloisa Tellez, Cepeda, Alejandro Valdes, Carrillo, Luis Venegas, Mesa, Juan Villagordoa, Escobedo, Rolando Zamarripa, Baker, John, Noonan, Paul, Scott, Russell, Walker, Robert, Watson, Edward, Williams, Michael, Young, Simon, Abejuela, Zaynab, Agra, Jeimeen, Aquitania, Grace, Caringal, Clodoaido, Comia, Rhea Severina, Santos, Lalaine Delos, Gomez, Olivert, Jimeno, Cecilia, Tan, Gerry, Tolentino, Marsha, Yao, Christy, Yap, Yvette Ethel, Lallaine Ygpuara, Ma. Dovie, Bijata-Bronisz, Renata, Hotlos, Lucyna, Januszewicz, Andrzej, Kaczmarek, Barbara, Kaminska, Anna, Lazuka, Lech, Madej, Andrzej, Mazur, Stanislaw, Mlodawska-Choluj, Dorota, Nowicki, Michal, Orlowska-Kowalik, Grazyna, Popenda, Grazyna, Rewerska, Barbara, Sowinski, Dariusz, Angelescu, Liliana Monica, Anghel, Veronica, Avram, Rodica-Ioana, Busegeanu, Mihaela-Magdalena, Cif, Adriana, Cosma, Dana, Crisan, Carmen, Demian, Luiza Despina, Ferariu, Ioana Emilia, Halmagyi, Ildiko, Hancu, Nicolae, Munteanu, Mircea, Negru, Doru, Onaca, Adriana Gabriela, Petrica, Ligia, Popa, Amorin Remus, Ranetti, Aurelian-Emil, Serafinceanu, Cristian, Toarba, Cristina, Agafyina, Alina, Barbarash, Olga, Barysheva, Olga, Chizhov, Daniil, Dobronravov, Vladimir, Glinkina, Irina, Grineva, Elena, Khirmanov, Vladimir, Kolmakova, Elena, Koroleva, Tatiana, Kvitkova, Liudmila, Marasaev, Viacheslav, Mkrtumyan, Ashot, Morugova, Tatiana, Nagibovich, Galina, Nagibovich, Oleg, Nedogoda, Sergei, Osipova, Irina, Raskina, Tatiana, Samoylova, Yulia, Sazonova, Olga, Shamkhalova, Minara, Shutemova, Elena, Shwartz, Yuriy, Uriasyev, Oleg, Vorobyev, Sergey, Zateyshchikova, Anna, Zateyshshikov, Dmitry, Zykova, Tatyana, Antic, Slobodan, Djordjevic, Miodrag, Kendereski, Aleksandra, Lalic, Katarina, Lalic, Nebojsa, Popovic-Radinovic, Vesna, Babikova, Jana, Benusova, Olga, Buganova, Ingrid, Culak, Jan, Dzupina, Andrej, Dzuponova, Jana, Fulop, Peter, Ilavska, Adriana, Martinka, Emil, Ochodnicka, Zuzana, Pella, Daniel, Smatanova, Iveta, Ahmed, Fayzal, Badat, Aysha, Breedt, Johannes, Distiller, Lawrence, Govender, Vimladhevi, Govender, Ravendran, Joshi, Mukesh, Jurgens, Jaco, Latiff, Gulam, Lombard, Landman, Mookadam, Mohamed, Ngcakani, Nomangesi, Nortje, Hendrik, Oosthuizen, Helena, Pillay-Ramaya, Larisha, Prozesky, Hans, Reddy, Jeevren, Rheeder, Paul, Seeber, Mary, Cho, Young Min, Jeong, In-Kyung, Kim, Sin Gon, Kim, Yeong Hoon, Kwon, Hyuk-Sang, Kwon, Min Jeong, Lee, Byung-Wan, Lee, JungEun, Lee, Moon-Kyu, Nam, Moon-Suk, Oh, Kook-Hwan, Park, Cheol- Young, Park, Sun-Hee, Yoon, Kun Ho, Garcia, Pere Alvarez, Mercadal, Luis Asmarats, Barrios, Clara, Castro, Fernando Cereto, Guldris, Secundino Cigarran, Lopez, Marta Dominguez, Egido de los Rios, Jesus, Fresnedo, Gema Fernandez, Serrano, Antonio Galan, Garcia, Isabel, Gonzalez Martinez, Francisco Javier, Jodar Gimeno, Jose Esteban, Mendoza, Manuel Lopez, Marin, Tamara Malek, Portillo, Cristobal Morales, Munar Vila, Maria Antonia, Torres, Manuel Muñoz, Iglesias, Javier Nieto, Perez, Jonay Pantoja, Vera, Merce Perez, Portoles Perez, Jose M., Quesada Simón, María Angustias, Canonge, Rafael Simo, Gonzalez, Alfonso Soto, Riera, Manel Terns, Tinahones Madueno, Francisco Jose, Plaza, Mercedes Velo, Chang, Chwen-Tzuei, Chuang, Lee-Ming, Hsia, Te-Lin, Hsieh, Chang-Hsun, Lin, Chih-Ching, Lu, Yung- Chuan, Sheu, Wayne H-H, Barna, Olga, Bilyk, Svitlana D., Botsyurko, Volodymyr, Dudar, Iryna, Fushtey, Ivan, Godlevska, Olga, Golovchenko, Oleksandr, Gyrina, Olga, Kazmirchuk, Anatoliy, Komisarenko, Iuliia, Korzh, Oleksii, Kravchun, Nonna, Legun, Oleg, Mankovskyy, Borys, Martynyuk, Liliya, Mostovoy, Yuriy, Pashkovska, Nataliia, Pererva, Larysa, Pertseva, Tetyana, Samoylov, Oleksandr, Smirnov, Ivan, Svyshchenko, Yevgeniya, Tomashkevych, Halyna, Topchii, Ivan, Tryshchuk, Nadiya, Tseluyko, Vira, Vizir, Vadym, Vlasenko, Maryna, Zlova, Tetiana, Zub, Liliia, Abusnana, Salah, Railey, Mohamed, Abouglila, Kamal, Ainsworth, Paul, Ali, Zishan, Arutchelvam, Vijayaraman, Barnard, Maria, Bellary, Srikanth, Davies, Emyr, Davies, Mark, Davies, Simon, Dawson, Alison, El Kossi, Mohsen, English, Patrick, Fraser, Donald, Gnudi, Luigi, Gunstone, Anthony, Hall, Timothy, Hanif, Wasim, Jackson, Alan, Johnson, Andrew, Joseph, Franklin, Krishnan, Singhan, Kumwenda, Mick, MacDougall, Iain, Nixon, Paul, O'Hare, Joseph, Philip, Sam, Ramtoola, Shenaz, Saxena, Manish, Sennik, Davesh, Simon, Godwin, Singh, Baldev, Stephens, Jeffrey, Strzelecka, Anna, Symonds, Rehan, Turner, Wayne, Wahba, Mona, Wakeling, John, Wheeler, David, Winocour, Peter, Abdallah, Joseph, Abdullah, Raied, Abramowitz, Matthew, Acosta, Idalia, Aiello, Joseph, Akright, Laura, Akyea-Djamson, Ayim, Alappan, Rajendran, Alicic, Radica, Al-Karadsheh, Amer, Allison, Dale Crawford, Arauz-Pacheco, Carlos, Arfeen, Shahabul, Arif, Ahmed, Arvind, Moogali, Atray, Naveen, Awad, Ahmed, Barnhill, Peggy, Barranco, Elizabeth, Barrera, Carlos, Beacom, Matthew, Behara, Venkata, Belo, Diogo, Bentley-Lewis, Rhonda, Berenguer, Ramon, Bermudez, Lidia, Bernardo, Marializa, Biscoveanu, Mihaela, Bowman-Stroud, Cynthia, Brandon, Donald, Brusco, Osvaldo, Busch, Robert, Canaan, Yamil, Chilito, Alicia, Christensen, Tom, Christiano, Cynthia, Christofides, Elena, Chuateco, Caroucel, Cohen, Kenneth, Cohen, Robert, Cohen-Stein, Debbie, Cook, Charles, Coyne, Daniel, Daboul, Nizar, Darwish, Riad, Daswani, Adarsh, Deck, Kenneth, Desouza, Cyrus, Dev, Devasmita, Dhillon, Monika, Dua, Sohan, Eder, Frank, Elosegui, Ana Maria, El-Shahawy, Mohamed, Ervin, John, Esquenazi, Alberto, Evans, John, Fishbane, Steven, Frias, Juan, Galindo-Ramos, Eugenia, Galphin, Claude, Ghazi, Adline, Gonzalez, Enrique, Gorson, David, Gowda, Anupama, Greco, Barbara, Grubb, Stephen, Gulati, Rakesh, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Hershon, Kenneth, Hiser, Daniel, Hon, George, Jacob, Radu, Jaime, Maria, Jamal, Aamir, Kaupke, Charles, Keightley, Gerald, Kern, Elizabeth, Khanna, Rakhi, Khitan, Zeid, Kim, Sun, Kopyt, Nelson, Kovesdy, Csaba, Krishna, Gopal, Kropp, Jeffrey (Jay), Kumar, Amrendra, Kumar, Jayant, Kumar, Neil, Kusnir, Jorge, Lane, Wendy, Lawrence, Mary, Lehrner, Lawrence, Lentz, John, Levinson, Dennis, Lewis, Derek, Liss, Kenneth, Maddux, Andreas, Maheshwari, Hiralal, Mandayam, Sreedhar, Marar, Isam, Mehta, Bhasker, Middleton, John, Mordujovich, Jorge, Moreda, Ramon, Moustafa, Moustafa, Trenche, Samuel Mujica, Narayanan, Mohanram, Narvarte, Javier, Nassar, Tareq, Newman, George, Nichol, Brian, Nicol, Philip, Nisnisan, Josier, Nossuli, A. Kaldun, Obialo, Chamberlain, Olelewe, Sarah, Oliver, Michael, O'Shaughnessy, Andrew, Padron, John, Pankhaniya, Rohit, Parker, Reginald, Patel, Devesh, Patel, Gnyandev, Patel, Nina, Pavon, Humberto, Perez, Armando, Perez, Carlos, Perlman, Alan, Pettis, Karlton, Pharr, Walter, Phillips, Andrea, Purighalla, Raman, Quesada-Suarez, Luis, Ranjan, Rajiv, Rastogi, Sanjeev, Reddy, Jakkidi, Rendell, Marc, Rich, Lisa, Robinson, Michael, Rodriguez, Hector, Rosas, Sylvia, Saba, Fadi, Sankaram, Rallabhandi, Sarin, Ravi, Schreiman, Robert, Scott, David, Sekkarie, Mohamed, Sensenbrenner, John, Shakeel, Muhammad, Shanik, Michael, Shaw, Sylvia, Smith, Stephen, Solomon, Richard, Sprague, Amy, Spry, Leslie, Suchinda, Pusadee, Sultan, Senan, Surampudi, Prasanth, Sussman, Sherry, Tan, Anjanette, Terrelonge, Antonio, Thompson, Michael, Trespalacios, Fernando, Trippe, Bruce, Trueba, Pilar, Twahirwa, Marcel, Updegrove, John, Van Buren, Peter, Vannorsdall, Mark, Varghese, Freemu, Velasquez-Mieyer, Pedro, Ventrapragada, Sailaja, Vukotic, Goga, Wadud, Khurram, Warren, Mark, Watson, Henry, Watts, Ronald, Weiner, Daniel, Welker, James, Welsh, Jean, Williams, Shelley, Zaniewski-Singh, Michelle, Yi, Tae Won, Smyth, Brendan, Di Tanna, Gian Luca, Arnott, Clare, Cardoza, Kathryn, and Kang, Amy

Published
2023
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4. The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination

Author

Fu, Meng-Meng, McAlear, Thomas S, Nguyen, Huy, Oses-Prieto, Juan A, Valenzuela, Alex, Shi, Rebecca D, Perrino, John J, Huang, Ting-Ting, Burlingame, Alma L, Bechstedt, Susanne, and Barres, Ben A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Animals, Animals, Newborn, Axons, Carrier Proteins, Cell-Free System, Cells, Cultured, Escherichia coli, Gene Knockdown Techniques, Golgi Apparatus, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Microtubule-Organizing Center, Microtubules, Myelin Sheath, Nerve Tissue Proteins, Oligodendrocyte Precursor Cells, Rats, Rats, Sprague-Dawley, Tubulin, Golgi outpost, TPPP, branching, mass spectrometry, microtubule, myelin, nucleation, oligodendrocyte, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Oligodendrocytes extend elaborate microtubule arbors that contact up to 50 axon segments per cell, then spiral around myelin sheaths, penetrating from outer to inner layers. However, how they establish this complex cytoarchitecture is unclear. Here, we show that oligodendrocytes contain Golgi outposts, an organelle that can function as an acentrosomal microtubule-organizing center (MTOC). We identify a specific marker for Golgi outposts-TPPP (tubulin polymerization promoting protein)-that we use to purify this organelle and characterize its proteome. In in vitro cell-free assays, recombinant TPPP nucleates microtubules. Primary oligodendrocytes from Tppp knockout (KO) mice have aberrant microtubule branching, mixed microtubule polarity, and shorter myelin sheaths when cultured on 3-dimensional (3D) microfibers. Tppp KO mice exhibit hypomyelination with shorter, thinner myelin sheaths and motor coordination deficits. Together, our data demonstrate that microtubule nucleation outside the cell body at Golgi outposts by TPPP is critical for elongation of the myelin sheath.

Published
2019

5. rWTC‐MBTA Vaccine Induces Potent Adaptive Immune Responses Against Glioblastomas via Dynamic Activation of Dendritic Cells

Author

Wang, Herui, primary, Medina, Rogelio, additional, Ye, Juan, additional, Zhang, Yaping, additional, Chakraborty, Samik, additional, Valenzuela, Alex, additional, Uher, Ondrej, additional, Hadrava Vanova, Katerina, additional, Sun, Mitchell, additional, Sang, Xueyu, additional, Park, Deric M., additional, Zenka, Jan, additional, Gilbert, Mark R., additional, Pacak, Karel, additional, and Zhuang, Zhengping, additional

Published
2024
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10. Despacho económico en centrales de generación térmicas considerando restricciones económicas y ambientales para la operación en isla de una red eléctrica industrial / Despacho econômico em usinas térmicas considerando restrições econômicas e ambientais para a operação insular de uma rede elétrica industrial

Author

Ruiz-Tipán, Fausto and Valenzuela, Alex

Subjects
algoritmo de la libélula, optimización multiobjetivo, General Materials Science, red industrial, despacho económico ambiental
Abstract

El despacho económico ambiental (DEA) es un trabajo de optimización sumamente relevante en la operación de una planta de energía que opera con combustibles fósiles, el primordial objetivo es que el costo de combustible y el nivel de emisiones se optimicen mientras se satisfacen todas las restricciones operativas del sistema. Este problema de optimización es multiobjetivo, donde se deben tomar en consideración varias restricciones. En el presente documento, se ha propuesto el algoritmo de la libélula (AL) para resolver el problema de (DEA). El algoritmo se ha validado en dos sistemas de prueba, uno de diez unidades generadoras y el otro de un sistema aislado de quince generadores (red industrial), además, los resultados han sido comparados con otros algoritmos, algoritmo genético (AG) y optimización por enjambre de partículas (PSO), así, se ha determinado la eficacia del AL para sistemas eléctricos de potencia.

Published
2022

12. Ajuste automático de la protección de sobrecorriente de tipo inverso en una red de distribución soterrada sujeto a la conmutación de equipos de seccionamiento / Ajuste automático de proteção de sobrecorrente de tipo inverso em uma rede de distribuição subterrânea sujeita a comutação de equipamentos de isolamento

Author

Campaña, Orlando and Valenzuela, Alex

Subjects
relé de tiempo inverso, Coordinación de protecciones, General Materials Science, Protección de sobrecorriente, Red de distribución soterrada, Reconfiguración de redes
Abstract

El desarrollo de los sistemas de distribución va ligado proporcionalmente con el crecimiento poblacional tanto en zonas urbanas como en zonas rurales, esto establece que un porcentaje relativamente alto de sistemas de distribución haya sido mudado desde sistemas aéreos a sistemas soterrados; a la par a ello la aplicación y coordinación de protecciones son temas que se han investigado a profundidad en los últimos años buscando diferentes técnicas que permitan una optimización para tener como resultado final un servicio de calidad y confiabilidad hacia el usuario. Este paper propone realizar un análisis de contingencia sobre un sistema de distribución radial para la obtención automática de los ajustes de las protecciones de sobrecorriente que permitan realizar la coordinación de estas, considerando la restauración de servicio en una red de distribución radial mediante el cambio de topología. Dentro del análisis se debe considerar las restricciones necesarias para la obtención del mejor punto de operación del sistema.

Published
2022

17. Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

Author

Abreu, Alin, Tovar, Alejandro Pinzón, Castellanos, Rafael, Valenzuela, Alex, Giraldo, Claudia Milena Gómez, Pinedo, Alejandro Castellanos, Guerrero, Doly Pantoja, Barrera, Carlos Alfonso Builes, Franco, Humberto Ignacio, Ribeiro-Oliveira, Jr., Antônio, Vilar, Lucio, Jallad, Raquel S., Duarte, Felipe Gaia, Gadelha, Mônica, Boguszewski, Cesar Luiz, Abucham, Julio, Naves, Luciana A., Musolino, Nina Rosa C., de Faria, Maria Estela Justamante, Rossato, Ciliana, and Bronstein, Marcello D.

Published
2016
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21. Ubicación de sistemas fotovoltaicos en la red de distribución de corriente continua en medio voltaje considerando edificaciones inteligentes y estaciones de carga de vehículos eléctricos / Localização de sistemas fotovoltaicos na rede de distribuição de corrente contínua em média tensão considerando edifícios inteligentes e estações de carregamento de veículos elétricos

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Pilatasig, Edgar, primary and Valenzuela, Alex, additional

Published
2022
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30. Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease

Author

Zhou, Zien, primary, Jardine, Meg J., additional, Li, Qiang, additional, Neuen, Brendon L., additional, Cannon, Christopher P., additional, de Zeeuw, Dick, additional, Edwards, Robert, additional, Levin, Adeera, additional, Mahaffey, Kenneth W., additional, Perkovic, Vlado, additional, Neal, Bruce, additional, Lindley, Richard I., additional, Ahuad Guerrero, Rodolfo Andres, additional, Aizenberg, Diego, additional, Albisu, Juan Pablo, additional, Alvarisqueta, Andres, additional, Bartolacci, Ines, additional, Berli, Mario Alberto, additional, Bordonava, Anselmo, additional, Calella, Pedro, additional, Cantero, Maria Cecilia, additional, Cartasegna, Luis Rodolfo, additional, Cercos, Esteban, additional, Coloma, Gabriela Cecilia, additional, Colombo, Hugo, additional, Commendatore, Victor, additional, Cuadrado, Jesus, additional, Cuneo, Carlos Alberto, additional, Cusumano, Ana Maria, additional, Douthat, Walter Guillermo, additional, Dran, Ricardo Dario, additional, Farias, Eduardo, additional, Fernandez, Maria Florencia, additional, Finkelstein, Hernan, additional, Fragale, Guillermo, additional, Fretes, Jose Osvaldo, additional, Garcia, Nestor Horacio, additional, Gastaldi, Anibal, additional, Gelersztein, Elizabeth, additional, Glenny, Jorge Archibaldo, additional, Gonzalez, Joaquin Pablo, additional, del Carmen Gonzalez Colaso, Patricia, additional, Goycoa, Claudia, additional, Greloni, Gustavo Cristian, additional, Guinsburg, Adrian, additional, Hermida, Sonia, additional, Juncos, Luis Isaias, additional, Klyver, Maria Isabel, additional, Kraft, Florencia, additional, Krynski, Fernando, additional, Lanchiotti, Paulina Virginia, additional, Leon de la Fuente, Ricardo Alfonso, additional, Marchetta, Nora, additional, Mele, Pablo, additional, Nicolai, Silvia, additional, Novoa, Pablo Antonio, additional, Orio, Silvia Ines, additional, Otreras, Fabian, additional, Oviedo, Alejandra, additional, Raffaele, Pablo, additional, Resk, Jorge Hector, additional, Rista, Lucas, additional, Rodriguez Papini, Nelson, additional, Sala, Jorgelina, additional, Santos, Juan Carlos, additional, Schiavi, Lilia Beatriz, additional, Sessa, Horacio, additional, Smith Casabella, Tomas, additional, Ulla, Maria Rosa, additional, Valdez, Maria, additional, Vallejos, Augusto, additional, Villarino, Adriana, additional, Visco, Virginia Esther, additional, Wassermann, Alfredo, additional, Zaidman, Cesar Javier, additional, Cheung, Ngai Wah, additional, Droste, Carolyn, additional, Fraser, Ian, additional, Johnson, David, additional, Mah, Peak Mann, additional, Nicholls, Kathy, additional, Packham, David, additional, Proietto, Joseph, additional, Roberts, Anthony, additional, Roger, Simon, additional, Tsang, Venessa, additional, Abrão Raduan, Roberto, additional, Alves da Costa, Fernando Augusto, additional, Amodeo, Celso, additional, Andreotti Turatti, Luiz Alberto, additional, Bregman, Rachel, additional, Camelo Sanches, Fernanda Cristina, additional, Canani, Luis Henrique, additional, Chacra, Antônio Roberto, additional, Cunha Borges, João Lindolfo, additional, Cunha Vêncio, Sérgio Alberto, additional, da Silva Franco, Roberto Jorge, additional, d’Avila, Domingos, additional, de Souza Portes, Evandro, additional, de Souza, Pedro, additional, Deboni, Luciane Mônica, additional, Fraige Filho, Fadlo, additional, Geloneze Neto, Bruno, additional, Gomes, Marcus, additional, Keiko Kohara, Suely, additional, Keitel, Elizete, additional, Kerr Saraiva, Jose Francisco, additional, Kurtz Lisboa, Hugo Roberto, additional, Loss de Carvalho Contieri, Fabiana, additional, Milagres, Rosângela, additional, Montenegro Junior, Renan, additional, Moreira de Brito, Claudia, additional, Nasser Hissa, Miguel, additional, Nazario Sabbag, Ângela Regina, additional, Noronha, Irene, additional, Panarotto, Daniel, additional, Pecoits Filho, Roberto, additional, Pereira, Márcio Antônio, additional, Saporito, Wladmir, additional, Scafuto Scotton, Antonio, additional, Schuch, Tiago, additional, Simões de Almeida, Roberto, additional, Slompo Ramos, Cássio, additional, Soares Felício, João, additional, Thomé, Fernando, additional, Tibes Hachmann, Jean Carlo, additional, Yamada, Sérgio, additional, Yoiti Hayashida, Cesar, additional, Zanata Petry, Tarissa Beatrice, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoria, additional, Angelova, Angelina, additional, Dimitrov, Stefan, additional, Genadieva, Veselka, additional, Genova-Hristova, Gabriela, additional, Hristozov, Kiril, additional, Kamenov, Zdravko, additional, Koundurdjiev, Atanas, additional, Lozanov, Lachezar, additional, Margaritov, Viktor, additional, Nonchev, Boyan, additional, Rangelov, Rangel, additional, Shinkov, Alexander, additional, Temelkova, Margarita, additional, Velichkova, Ekaterina, additional, Yakov, Andrian, additional, Aggarwal, Naresh, additional, Aronson, Ronnie, additional, Bajaj, Harpreet, additional, Cherney, David, additional, Chouinard, Guy, additional, Conway, James, additional, Cournoyer, Serge, additional, DaRoza, Gerald, additional, De Serres, Sacha, additional, Dubé, François, additional, Goldenberg, Ronald, additional, Gupta, Anil, additional, Gupta, Milan, additional, Henein, Sam, additional, Khandwala, Hasnain, additional, Leiter, Lawrence, additional, Madore, François, additional, McMahon, Alan, additional, Muirhead, Norman, additional, Pichette, Vincent, additional, Rabasa-Lhoret, Remi, additional, Steele, Andrew, additional, Tangri, Navdeep, additional, Torshizi, Ali, additional, Woo, Vincent, additional, Zalunardo, Nadia, additional, Fernández Montenegro, María Alicia, additional, Godoy Jorquera, Juan Gonzalo, additional, Medina Fariña, Marcelo, additional, Saavedra Gajardo, Victor, additional, Vejar, Margarita, additional, Chen, Nan, additional, Chen, Qinkai, additional, Gan, Shenglian, additional, Kong, Yaozhong, additional, Li, Detian, additional, Li, Wenge, additional, Li, Xuemei, additional, Lin, Hongli, additional, Liu, Jian, additional, Lu, Weiping, additional, Mao, Hong, additional, Ren, Yan, additional, Song, Weihong, additional, Sun, Jiao, additional, Sun, Lin, additional, Tu, Ping, additional, Wang, Guixia, additional, Yang, Jinkui, additional, Yin, Aiping, additional, Yu, Xueqing, additional, Zhao, Minghui, additional, Zheng, Hongguang, additional, Accini Mendoza, Jose Luis, additional, Arcos, Edgar, additional, Avendano, Jorge, additional, Diaz Ruiz, Jorge Ernesto Andres, additional, Garcia Ortiz, Luis Hernando, additional, Gonzalez, Alexander, additional, Hernandez Triana, Eric, additional, Higuera, Juan Diego, additional, Malaver, Natalia, additional, Molina de Salazar, Dora Inés, additional, Rosero, Ricardo, additional, Terront Lozano, Monica Alexandra, additional, Valderrama Cometa, Luis, additional, Valenzuela, Alex, additional, Vargas Alonso, Ruben Dario, additional, Villegas, Ivan, additional, Yupanqui, Hernan, additional, Bartaskova, Dagmar, additional, Barton, Petr, additional, Belobradkova, Jana, additional, Dohnalova, Lenka, additional, Drasnar, Tomas, additional, Ferkl, Richard, additional, Halciakova, Katarina, additional, Klokocnikova, Vera, additional, Kovar, Richard, additional, Lastuvka, Jiri, additional, Lukac, Martin, additional, Pesickova, Satu, additional, Peterka, Karel, additional, Pumprla, Jiri, additional, Rychlik, Ivan, additional, Saudek, Frantisek, additional, Tesar, Vladimir, additional, Valis, Martin, additional, Weiner, Pavel, additional, Zemek, Stanislav, additional, Alamartine, Eric, additional, Borot, Sophie, additional, Cariou, Bertrand, additional, Dussol, Bertrand, additional, Fauvel, Jean-Pierre, additional, Gourdy, Pierre, additional, Klein, Alexandre, additional, Le Meur, Yannick, additional, Penfornis, Alfred, additional, Roussel, Ronan, additional, Saulnier, Pierre-Jean, additional, Thervet, Eric, additional, Zaoui, Philippe, additional, Burst, Volker, additional, Faghih, Markus, additional, Faulmann, Grit, additional, Haller, Hermann, additional, Jerwan-Keim, Reinhold, additional, Maxeiner, Stephan, additional, Paschen, Björn, additional, Plassmann, Georg, additional, Rose, Ludger, additional, Gonzalez Orellana, Ronaldo Arturo, additional, Haase, Franklin Paul, additional, Moreira Diaz, Juan Pablo, additional, Ramirez Roca, Luis Alberto, additional, Sánchez Arenales, Jose Antonio, additional, Sanchez Polo, José Vicente, additional, Turcios Juarez, Erick, additional, Csecsei, Gyongyi, additional, Csiky, Botond, additional, Danos, Peter, additional, Deak, Laszlo, additional, Dudas, Mihaly, additional, Harcsa, Eleonora, additional, Keltai, Katalin, additional, Keresztesi, Sandor, additional, Kiss, Krisztian, additional, Konyves, Laszlo, additional, Major, Lajos, additional, Mileder, Margit, additional, Molnar, Marta, additional, Mucsi, Janos, additional, Oroszlan, Tamas, additional, Ory, Ivan, additional, Paragh, Gyorgy, additional, Peterfai, Eva, additional, Petro, Gizella, additional, Revesz, Katalin, additional, Takacs, Robert, additional, Vangel, Sandor, additional, Vasas, Szilard, additional, Zsom, Marianna, additional, Oomman, Abraham, additional, Raju, Sree Bhushan, additional, Dewan, Deepak, additional, Fernando, M. Edwin, additional, Gopalakrishnan, Natarajan, additional, Gracious, Noble, additional, Alva, Hansraj, additional, Jain, Dinesh, additional, Keshavamurthy, C. B., additional, Khullar, Dinesh, additional, Sahay, Manisha, additional, Peringat, Jayameena, additional, Prasad, Narayan, additional, Rao, K. Satyanarayana, additional, Reddy, Sreedhar, additional, Melemadathil, Sreelatha, additional, Sudhakar, Bhimavarapu, additional, Vyasam, Ramesh Chandra, additional, Bonadonna, Riccardo, additional, Castellino, Pietro, additional, Ceriello, Antonio, additional, Chiovato, Luca, additional, De Cosmo, Salvatore, additional, De Nicola, Luca, additional, Derosa, Giuseppe, additional, Di Carlo, Alberto, additional, Di Cianni, Graziano, additional, Frascà, Giovanni, additional, Fuiano, Giorgio, additional, Gambaro, Giovanni, additional, Garibotto, Giacomo, additional, Giorda, Carlo, additional, Malberti, Fabio, additional, Mandreoli, Marcora, additional, Mannucci, Edoardo, additional, Orsi, Emanuela, additional, Piatti, Piermarco, additional, Santoro, Domenico, additional, Sasso, Ferdinando Carlo, additional, Serviddio, Gaetano, additional, Stella, Andrea, additional, Trevisan, Roberto, additional, Veronelli, Anna Maria, additional, Zanoli, Luca, additional, Akiyama, Hitoshi, additional, Aoki, Hiromi, additional, Asano, Akimichi, additional, Iitsuka, Tadashi, additional, Kajiyama, Shizuo, additional, Kashine, Susumu, additional, Kawada, Toshio, additional, Kodera, Takamoto, additional, Kono, Hiroshi, additional, Koyama, Kazunori, additional, Kumeda, Yasuro, additional, Miyauchi, Shozo, additional, Mizuyama, Kazuyuki, additional, Niiya, Tetsuji, additional, Oishi, Hiroko, additional, Ota, Satoshi, additional, Sakakibara, Terue, additional, Takai, Masahiko, additional, Tomonaga, Osamu, additional, Tsujimoto, Mitsuru, additional, Wada, Takashi, additional, Wakasugi, Masakiyo, additional, Wakida, Yasushi, additional, Watanabe, Takayuki, additional, Yamada, Masayo, additional, Yanagida, Kazuhiro, additional, Yanase, Toshihiko, additional, Yumita, Wataru, additional, Gaupsiene, Egle, additional, Kozloviene, Dalia, additional, Navickas, Antanas, additional, Urbanaviciene, Egle, additional, Abdul Ghani, Rohana, additional, Abdul Kadir, Khalid, additional, Ali, Norsiah, additional, Che Yusof, Mohd Daud, additional, Gan, Chye Lee, additional, Ismail, Mastura, additional, Kong, Wei Yen, additional, Lam, Swee Win, additional, Lee, Li Yuan, additional, Lim, Soo Kun, additional, Loh, Chek Loong, additional, Manocha, Anita Bhajan, additional, Ng, Kee Sing, additional, Nik Ahmad, Nik Nur Fatnoon, additional, Ratnasingam, Vanassa, additional, Shudim, Saiful Shahrizal Bin, additional, Vengadasalam, Paranthaman, additional, Abraira Munoz, Luis David, additional, Alpizar Salazar, Melchor, additional, Baas Cruz, Juan, additional, Burgos Soto, Mario, additional, Chevaile Ramos, Jose, additional, Chew Wong, Alfredo, additional, Correa Rotter, Jose Ricardo, additional, Diaz Escalante, Tonatiu, additional, Enriquez Sosa, Favio Edmundo, additional, Flores Lozano, Fernando, additional, Flota Cervera, Luis Fernando, additional, Frenk Baron, Paul, additional, Garcia Ballesteros, Cecilia, additional, Gomez Rangel, Jose David, additional, Herrera Jimenez, Luis Enrique, additional, Irizar Santana, Sergio Saul, additional, Jimenez Flores, Fernando, additional, Laviada Molina, Hugo, additional, Luna Ceballos, Rosa Isela, additional, Martin del Campo Blanco, Belia, additional, Morales Franco, Guadalupe, additional, Moreno Loza, Oscar Tarsicio, additional, Mustieles Rocha, Cynthia, additional, Obrador Vera, Gregorio, additional, Orozco Castellanos, Ricardo, additional, Peralta Calcaneo, Juan, additional, Reyes Rosano, Miguel Angel, additional, Rodriguez Pattzi, Hiromi, additional, Rosas Guzman, Juan, additional, Rucker Joerg, Isabel Erika, additional, Saavedra Sanchez, Sandra Berenice, additional, Sanchez Mijangos, Jose Hector, additional, Serrano Sanson, Pablo, additional, Tamayo y Orozco, Juan Alfredo, additional, Tellez Chavez, Eloisa, additional, Valdes Cepeda, Alejandro, additional, Venegas Carrillo, Luis, additional, Villagordoa Mesa, Juan, additional, Zamarripa Escobedo, Rolando, additional, Baker, John, additional, Noonan, Paul, additional, Scott, Russell, additional, Walker, Robert, additional, Watson, Edward, additional, Williams, Michael, additional, Young, Simon, additional, Abejuela, Zaynab, additional, Agra, Jeimeen, additional, Aquitania, Grace, additional, Caringal, Clodoaido, additional, Comia, Rhea Severina, additional, Delos Santos, Lalaine, additional, Gomez, Olivert, additional, Jimeno, Cecilia, additional, Santos, Florence, additional, Tan, Gerry, additional, Tolentino, Marsha, additional, Yao, Christy, additional, Yap, Yvette Ethel, additional, Ygpuara, Ma. Dovie Lallaine, additional, Bijata-Bronisz, Renata, additional, Hotlos, Lucyna, additional, Januszewicz, Andrzej, additional, Kaczmarek, Barbara, additional, Kaminska, Anna, additional, Lazuka, Lech, additional, Madej, Andrzej, additional, Mazur, Stanislaw, additional, Mlodawska-Choluj, Dorota, additional, Nowicki, Michal, additional, Orlowska-Kowalik, Grazyna, additional, Popenda, Grazyna, additional, Rewerska, Barbara, additional, Sowinski, Dariusz, additional, Angelescu, Liliana Monica, additional, Anghel, Veronica, additional, Avram, Rodica-Ioana, additional, Busegeanu, Mihaela-Magdalena, additional, Cif, Adriana, additional, Cosma, Dana, additional, Crisan, Carmen, additional, Demian, Luiza Despina, additional, Ferariu, Ioana Emilia, additional, Halmagyi, Ildiko, additional, Hancu, Nicolae, additional, Munteanu, Mircea, additional, Negru, Doru, additional, Onaca, Adriana Gabriela, additional, Petrica, Ligia, additional, Popa, Amorin Remus, additional, Ranetti, Aurelian-Emil, additional, Serafinceanu, Cristian, additional, Toarba, Cristina, additional, Agafyina, Alina, additional, Barbarash, Olga, additional, Barysheva, Olga, additional, Chizhov, Daniil, additional, Dobronravov, Vladimir, additional, Dreval, Alexander, additional, Glinkina, Irina, additional, Grineva, Elena, additional, Khirmanov, Vladimir, additional, Kolmakova, Elena, additional, Koroleva, Tatiana, additional, Kvitkova, Liudmila, additional, Marasaev, Viacheslav, additional, Mkrtumyan, Ashot, additional, Morugova, Tatiana, additional, Nagibovich, Galina, additional, Nagibovich, Oleg, additional, Nedogoda, Sergei, additional, Osipova, Irina, additional, Raskina, Tatiana, additional, Samoylova, Yulia, additional, Sazonova, Olga, additional, Shamkhalova, Minara, additional, Shutemova, Elena, additional, Shwartz, Yuriy, additional, Uriasyev, Oleg, additional, Vorobyev, Sergey, additional, Zateyshchikova, Anna, additional, Zateyshshikov, Dmitry, additional, Zykova, Tatyana, additional, Antic, Slobodan, additional, Djordjevic, Miodrag, additional, Kendereski, Aleksandra, additional, Lalic, Katarina, additional, Lalic, Nebojsa, additional, Popovic-Radinovic, Vesna, additional, Babikova, Jana, additional, Benusova, Olga, additional, Buganova, Ingrid, additional, Culak, Jan, additional, Dzupina, Andrej, additional, Dzuponova, Jana, additional, Fulop, Peter, additional, Ilavska, Adriana, additional, Martinka, Emil, additional, Ochodnicka, Zuzana, additional, Pella, Daniel, additional, Smatanova, Iveta, additional, Ahmed, Fayzal, additional, Badat, Aysha, additional, Breedt, Johannes, additional, Distiller, Lawrence, additional, Govender, Vimladhevi, additional, Govender, Ravendran, additional, Joshi, Mukesh, additional, Jurgens, Jaco, additional, Latiff, Gulam, additional, Lombard, Landman, additional, Mookadam, Mohamed, additional, Ngcakani, Nomangesi, additional, Nortje, Hendrik, additional, Oosthuizen, Helena, additional, Pillay-Ramaya, Larisha, additional, Prozesky, Hans, additional, Reddy, Jeevren, additional, Rheeder, Paul, additional, Seeber, Mary, additional, Chae, Dong-Wan, additional, Cho, Young Min, additional, Jeong, In-Kyung, additional, Kim, Sin Gon, additional, Kim, Yeong Hoon, additional, Kwon, Hyuk-Sang, additional, Kwon, Min Jeong, additional, Lee, Byung-Wan, additional, Lee, JungEun, additional, Lee, Moon-Kyu, additional, Nam, Moon-Suk, additional, Oh, Kook-Hwan, additional, Park, Cheol-Young, additional, Park, Sun-Hee, additional, Yoon, Kun Ho, additional, Alvarez Garcia, Pere, additional, Asmarats Mercadal, Luis, additional, Barrios, Clara, additional, Cereto Castro, Fernando, additional, Cigarran Guldris, Secundino, additional, Dominguez Lopez, Marta, additional, Egido de los Rios, Jesus, additional, Fernandez Fresnedo, Gema, additional, Galan Serrano, Antonio, additional, Garcia, Isabel, additional, Gonzalez Martinez, Francisco Javier, additional, Jodar Gimeno, Jose Esteban, additional, Lopez Mendoza, Manuel, additional, Malek Marin, Tamara, additional, Morales Portillo, Cristobal, additional, Munar Vila, Maria Antonia, additional, Muñoz Torres, Manuel, additional, Nieto Iglesias, Javier, additional, Pantoja Perez, Jonay, additional, Perez Vera, Merce, additional, Portoles Perez, Jose Mª, additional, Quesada Simón, María Angustias, additional, Simo Canonge, Rafael, additional, Soto Gonzalez, Alfonso, additional, Terns Riera, Manel, additional, Tinahones Madueno, Francisco Jose, additional, Velo Plaza, Mercedes, additional, Chang, Chwen-Tzuei, additional, Chuang, Lee-Ming, additional, Hsia, Te-Lin, additional, Hsieh, Chang-Hsun, additional, Hwang, Shang-Jyh, additional, Lin, Chih-Ching, additional, Lu, Yung-Chuan, additional, Sheu, Wayne H-H, additional, Barna, Olga, additional, Bilyk, Svitlana D., additional, Botsyurko, Volodymyr, additional, Dudar, Iryna, additional, Fushtey, Ivan, additional, Godlevska, Olga, additional, Golovchenko, Oleksandr, additional, Gyrina, Olga, additional, Kazmirchuk, Anatoliy, additional, Kolesnyk, Mykola, additional, Komisarenko, Iuliia, additional, Korzh, Oleksii, additional, Kravchun, Nonna, additional, Legun, Oleg, additional, Mankovskyy, Borys, additional, Martynyuk, Liliya, additional, Mostovoy, Yuriy, additional, Pashkovska, Nataliia, additional, Pererva, Larysa, additional, Pertseva, Tetyana, additional, Samoylov, Oleksandr, additional, Smirnov, Ivan, additional, Svyshchenko, Yevgeniya, additional, Tomashkevych, Halyna, additional, Topchii, Ivan, additional, Tryshchuk, Nadiya, additional, Tseluyko, Vira, additional, Vizir, Vadym, additional, Vlasenko, Maryna, additional, Zlova, Tetiana, additional, Zub, Liliia, additional, Abusnana, Salah, additional, Railey, Mohamed, additional, Abouglila, Kamal, additional, Ainsworth, Paul, additional, Ali, Zishan, additional, Arutchelvam, Vijayaraman, additional, Barnard, Maria, additional, Bellary, Srikanth, additional, Davies, Emyr, additional, Davies, Mark, additional, Davies, Simon, additional, Dawson, Alison, additional, El Kossi, Mohsen, additional, English, Patrick, additional, Fraser, Donald, additional, Gnudi, Luigi, additional, Gunstone, Anthony, additional, Hall, Timothy, additional, Hanif, Wasim, additional, Jackson, Alan, additional, Johnson, Andrew, additional, Joseph, Franklin, additional, Krishnan, Singhan, additional, Kumwenda, Mick, additional, MacDougall, Iain, additional, Nixon, Paul, additional, O’Hare, Joseph, additional, Philip, Sam, additional, Ramtoola, Shenaz, additional, Saxena, Manish, additional, Sennik, Davesh, additional, Simon, Godwin, additional, Singh, Baldev, additional, Stephens, Jeffrey, additional, Strzelecka, Anna, additional, Symonds, Rehan, additional, Turner, Wayne, additional, Wahba, Mona, additional, Wakeling, John, additional, Wheeler, David, additional, Winocour, Peter, additional, Abdallah, Joseph, additional, Abdullah, Raied, additional, Abramowitz, Matthew, additional, Acosta, Idalia, additional, Aiello, Joseph, additional, Akright, Laura, additional, Akyea-Djamson, Ayim, additional, Alappan, Rajendran, additional, Alicic, Radica, additional, Al-Karadsheh, Amer, additional, Allison, Dale Crawford, additional, Arauz-Pacheco, Carlos, additional, Arfeen, Shahabul, additional, Arif, Ahmed, additional, Arvind, Moogali, additional, Atray, Naveen, additional, Awad, Ahmed, additional, Bakris, George, additional, Barnhill, Peggy, additional, Barranco, Elizabeth, additional, Barrera, Carlos, additional, Beacom, Matthew, additional, Behara, Venkata, additional, Belo, Diogo, additional, Bentley-Lewis, Rhonda, additional, Berenguer, Ramon, additional, Bermudez, Lidia, additional, Bernardo, Marializa, additional, Biscoveanu, Mihaela, additional, Bowman-Stroud, Cynthia, additional, Brandon, Donald, additional, Brusco, Osvaldo, additional, Busch, Robert, additional, Canaan, Yamil, additional, Chilito, Alicia, additional, Christensen, Tom, additional, Christiano, Cynthia, additional, Christofides, Elena, additional, Chuateco, Caroucel, additional, Cohen, Kenneth, additional, Cohen, Robert, additional, Cohen-Stein, Debbie, additional, Cook, Charles, additional, Coyne, Daniel, additional, Daboul, Nizar, additional, Darwish, Riad, additional, Daswani, Adarsh, additional, Deck, Kenneth, additional, Desouza, Cyrus, additional, Dev, Devasmita, additional, Dhillon, Monika, additional, Dua, Sohan, additional, Eder, Frank, additional, Elosegui, Ana Maria, additional, El-Shahawy, Mohamed, additional, Ervin, John, additional, Esquenazi, Alberto, additional, Evans, John, additional, Fishbane, Steven, additional, Frias, Juan, additional, Galindo-Ramos, Eugenia, additional, Galphin, Claude, additional, Ghazi, Adline, additional, Gonzalez, Enrique, additional, Gorson, David, additional, Gowda, Anupama, additional, Greco, Barbara, additional, Grubb, Stephen, additional, Gulati, Rakesh, additional, Hammoud, Jamal, additional, Handelsman, Stuart, additional, Hartman, Israel, additional, Hershon, Kenneth, additional, Hiser, Daniel, additional, Hon, George, additional, Jacob, Radu, additional, Jaime, Maria, additional, Jamal, Aamir, additional, Kaupke, Charles, additional, Keightley, Gerald, additional, Kern, Elizabeth, additional, Khanna, Rakhi, additional, Khitan, Zeid, additional, Kim, Sun, additional, Kopyt, Nelson, additional, Kovesdy, Csaba, additional, Krishna, Gopal, additional, Kropp, Jeffrey (Jay), additional, Kumar, Amrendra, additional, Kumar, Jayant, additional, Kumar, Neil, additional, Kusnir, Jorge, additional, Lane, Wendy, additional, Lawrence, Mary, additional, Lehrner, Lawrence, additional, Lentz, John, additional, Levinson, Dennis, additional, Lewis, Derek, additional, Liss, Kenneth, additional, Maddux, Andreas, additional, Maheshwari, Hiralal, additional, Mandayam, Sreedhar, additional, Marar, Isam, additional, Mehta, Bhasker, additional, Middleton, John, additional, Mordujovich, Jorge, additional, Moreda, Ramon, additional, Moustafa, Moustafa, additional, Mujica Trenche, Samuel, additional, Narayanan, Mohanram, additional, Narvarte, Javier, additional, Nassar, Tareq, additional, Newman, George, additional, Nichol, Brian, additional, Nicol, Philip, additional, Nisnisan, Josier, additional, Nossuli, A. Kaldun, additional, Obialo, Chamberlain, additional, Olelewe, Sarah, additional, Oliver, Michael, additional, O’Shaughnessy, Andrew, additional, Padron, John, additional, Pankhaniya, Rohit, additional, Parker, Reginald, additional, Patel, Devesh, additional, Patel, Gnyandev, additional, Patel, Nina, additional, Pavon, Humberto, additional, Perez, Armando, additional, Perez, Carlos, additional, Perlman, Alan, additional, Pettis, Karlton, additional, Pharr, Walter, additional, Phillips, Andrea, additional, Purighalla, Raman, additional, Quesada-Suarez, Luis, additional, Ranjan, Rajiv, additional, Rastogi, Sanjeev, additional, Reddy, Jakkidi, additional, Rendell, Marc, additional, Rich, Lisa, additional, Robinson, Michael, additional, Rodriguez, Hector, additional, Rosas, Sylvia, additional, Saba, Fadi, additional, Sankaram, Rallabhandi, additional, Sarin, Ravi, additional, Schreiman, Robert, additional, Scott, David, additional, Sekkarie, Mohamed, additional, Sensenbrenner, John, additional, Shakeel, Muhammad, additional, Shanik, Michael, additional, Shaw, Sylvia, additional, Smith, Stephen, additional, Solomon, Richard, additional, Sprague, Amy, additional, Spry, Leslie, additional, Suchinda, Pusadee, additional, Sultan, Senan, additional, Surampudi, Prasanth, additional, Sussman, Sherry, additional, Tan, Anjanette, additional, Terrelonge, Antonio, additional, Thompson, Michael, additional, Trespalacios, Fernando, additional, Trippe, Bruce, additional, Trueba, Pilar, additional, Twahirwa, Marcel, additional, Updegrove, John, additional, Van Buren, Peter, additional, Vannorsdall, Mark, additional, Varghese, Freemu, additional, Velasquez-Mieyer, Pedro, additional, Ventrapragada, Sailaja, additional, Vukotic, Goga, additional, Wadud, Khurram, additional, Warren, Mark, additional, Watson, Henry, additional, Watts, Ronald, additional, Weiner, Daniel, additional, Welker, James, additional, Welsh, Jean, additional, Williams, Shelley, additional, and Zaniewski-Singh, Michelle, additional

Published
2021
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31. Métodos de Simulación de Armónicos en Sistemas Eléctricos de Potencia

Author

Barrera, Carlos and Valenzuela, Alex

Subjects
Simulación de armónicos, Métodos de simulación de armónicos, elementos no lineales, Harmonic domain, hybrid frequency-time domain, nonlinear elements, time varying
Abstract

La simulación de armónicos en sistemas de potencia puede realizarse mediante métodos que empleen la dependencia temporal o la dependencia frecuencial de los sistemas eléctricos. Todos los métodos detallados requieren de la solución de las ecuaciones de la red, y es en la forma de estas ecuaciones que los métodos se diferencian. La robustez y rápida convergencia hacen que unos métodos sean más empleados porque pueden entregar resultados más precisos. Los diversos componentes de la red deben ser modelados apropiadamente para que puedan reflejar su comportamiento cuando las variables de estado del sistema tienen a tomar formas altamente distorsionadas y para esto se deben tomar los modelos que se detallan en la literatura. Una vez que se realizan simulaciones de armónicos, se deben comparar los resultados obtenidos con aquellos límites que figuran en normativas específicas de calidad de energía y, en caso de ser excesiva la emisión el paso a seguir es el diseño de estrategias o sistemas de mitigación de armónicos. The harmonic simulation on power systems can be performed using methodologies which are focused on time and frequency domain. The solution of power systems under harmonics require a complete and detailed solution of grid equations, and consequently, different techniques and methodologies are used to solve these equations, which are used based on its application, due to the act that robustness and convergence speed. On the other hand, not only methodologies are important, but also component models, which it is a mathematical representation of real behavior of electrical devices on power systems. Set in this context, models and techniques are essential to simulate and obtain results, which are measured and compared with international standards on electric power quality, subsequently, impacts and possible techniques for power quality improvement by mitigation of harmonics could be proposed.

Published
2020

32. Maturity-onset diabetes of the young type 5 a MULTISYSTEMIC disease: a CASE report of a novel mutation in the HNF1B gene and literature review

Author

Lizcano, Fernando, O’Meara, Miguel, Mateus, Juan Camilo, Valenzuela, Alex, and Rivera, Carolina

Abstract

Antecedentes: la diabetes mellitus con herencia autosómica dominante, como la diabetes joven de inicio en la madurez (MODY), es una forma genética de diabetes mellitus. MODY es un tipo de diabetes mellitus monogénica en la que múltiples variantes genéticas pueden alterar el funcionamiento de las células beta. Las tres formas más conocidas de MODY son causadas por modificaciones en los genes hnf4a, gck y hnf1a. Sin embargo, otras variantes de MODY pueden provocar múltiples alteraciones en el desarrollo embrionario del endodermo. Este es el caso de los pacientes que presentan MODY5, que tienen una mutación del gen del factor nuclear hepático 1B (hnf1b). Presentación del caso: Presentamos el caso clínico de un paciente de 15 años con antecedentes familiares de diabetes mellitus y fenotipo clásico MODY tipo 5 (MODY5) que afecta al páncreas y al riñón, con una nueva mutación no reportada en el gen hnf1b. Conclusiones: MODY5 se caracteriza por una mutación en el gen hnf1b, que juega un papel importante en el desarrollo y función de múltiples órganos. Debe sospecharse en pacientes con diabetes inusual y afectación multisistémica no relacionada con la diabetes.

Published
2020
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42. Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Author

Mahaffey, Kw, Jardine, Mj, Bompoint, S, Cannon, Cp, Neal, B, Heerspink, Hjl, Charytan, Dm, Edwards, R, Agarwal, R, Bakris, G, Bull, S, Capuano, G, de Zeeuw, D, Greene, T, Levin, A, Pollock, C, Sun, T, Wheeler, Dc, Yavin, Y, Zhang, H, Zinman, B, Rosenthal, N, Brenner, Bm, Perkovic, V, Guerrero, Raa, Aizenberg, D, Albisu, Jp, Alvarisqueta, A, Bartolacci, I, Berli, Ma, Bordonava, A, Calella, P, Cantero, Mc, Cartasegna, Lr, Cercos, E, Coloma, Gc, Colombo, H, Commendatore, V, Cuadrado, J, Cuneo, Ca, Cusumano, Am, Douthat, Wg, Dran, Rd, Farias, E, Fernandez, Mf, Finkelstein, H, Fragale, G, Fretes, Jo, Garcia, Nh, Gastaldi, A, Gelersztein, E, Glenny, Ja, Gonzalez, Jp, Colaso, Pdg, Goycoa, C, Greloni, Gc, Guinsburg, A, Hermida, S, Juncos, Li, Klyver, Mi, Kraft, F, Krynski, F, Lanchiotti, Pv, de la Fuente, Ral, Marchetta, N, Mele, P, Nicolai, S., Novoa, Pa, Orio, Si, Otreras, F, Oviedo, A, Raffaele, P, Resk, Jh, Rista, L, Papini, Nr, Sala, J, Santos, Jc, Schiavi, Lb, Sessa, H, Casabella, Ts, Ulla, Mr, Valdez, M, Vallejos, A, Villarino, A, Visco, Ve, Wassermann, A, Zaidman, Cj, Cheung, Nw, Droste, C, Fraser, I, Johnson, D, Mah, Pm, Nicholls, K, Packham, D, Proietto, J, Roberts, A, Roger, S, Tsang, V, Raduan, Ra, da Costa, Faa, Amodeo, C, Turatti, Laa, Bregman, R, Sanches, Fcc, Canani, Lh, Chacra, Ar, Cunha Borges, Jl, Vencio, Sac, Franco, Rjd, D'Avila, D, Portes, Ed, de Souza, P, Deboni, Lm, Fraige, F, Neto, Bg, Gomes, M, Kohara, Sk, Keitel, E, Saraiva, Jfk, Lisboa, Hrk, Contieri, Fld, Milagres, R, Montenegro, R, de Brito, Cm, Hissa, Mn, Sabbag, Arn, Noronha, I, Panarotto, D, Pecoits, R, Pereira, Ma, Saporito, W, Scotton, As, Schuch, T, de Almeida, Rs, Ramos, Cs, Felicio, Js, Thome, F, Hachmann, Jct, Yamada, S, Hayashida, Cy, Petry, Tbz, Zanella, Mt, Andreeva, V, Angelova, A, Dimitrov, S, Genadieva, V, Genova-Hristova, G, Hristozov, K, Kamenov, Z, Koundurdjiev, A, Lozanov, L, Margaritov, V, Nonchev, B, Rangelov, R, Shinkov, A., Temelkova, M, Velichkova, E, Yakov, A, Aggarwal, N, Aronson, R, Bajaj, H, Cherney, D, Chouinard, G, Conway, J, Cournoyer, S, Daroza, G, De Serres, S, Dube, F, Goldenberg, R, Gupta, A, Gupta, M, Henein, S, Khandwala, H, Leiter, L, Madore, F, Mcmahon, A, Muirhead, N, Pichette, V, Rabasa-Lhoret, R, Steele, A, Tangri, N, Torshizi, A, Woo, V, Zalunardo, Nadia, Fernandez Montenegro, Maria Alicia, Godoy Jorquera, Juan Gonzalo, Medina Farina, Marcelo, Saavedra Gajardo, Victor, Vejar, Margarita, Chen, Nan, Chen, Qinkai, Gan, Shenglian, Kong, Yaozhong, Detian, Li, Wenge, Li, Xuemei, Li, Lin, Hongli, Liu, Jian, Weiping, Lu, Mao, Hong, Ren, Yan, Song, Weihong, Sun, Jiao, Sun, Lin, Ping, Tu, Wang, Guixia, Yang, Jinkui, Yin, Aiping, Xueqing, Yu, Zhao, Minghui, Zheng, Hongguang, Accini Mendoza, Jose Luis, Arcos, Edgar, Avendano, Jorge, Diaz Ruiz, Jorge Ernesto Andres, Garcia Ortiz, Luis Hernando, Gonzalez, Alexander, Hernandez Triana, Eric, Diego Higuera, Juan, Malaver, Natalia, Ines Molina de Salazar, Dora, Rosero, Ricardo, Terront Lozano, Monica Alexandra, Valderrama Cometa, Luis, Valenzuela, Alex, Vargas Alonso, Ruben Dario, Villegas, Ivan, Yupanqui, Hernan, Bartaskova, Dagmar, Barton, Petr, Belobradkova, Jana, Dohnalova, Lenka, Drasnar, Tomas, Ferkl, Richard, Halciakova, Katarina, Klokocnikova, Vera, Kovar, Richard, Lastuvka, Jiri, Lukac, Martin, Pesickova, Satu, Peterka, Karel, Pumprla, Jiri, Rychlik, Ivan, Saudek, Frantisek, Tesar, Vladimir, Valis, Martin, Weiner, Pavel, Zemek, Stanislav, Alamartine, Eric, Borot, Sophie, Cariou, Bertrand, Dussol, Bertrand, Fauvel, Jean-Pierre, Gourdy, Pierre, Klein, Alexandre, Le Meur, Yannick, Penfornis, Alfred, Roussel, Ronan, Saulnier, Pierre-Jean, Thervet, Eric, Zaoui, Philippe, Burst, Volker, Faghih, Markus, Faulmann, Grit, Haller, Hermann, Jerwan-Keim, Reinhold, Maxeiner, Stephan, Paschen, Bjoern, Plassmann, Georg, Rose, Ludger, Gonzalez Orellana, Ronaldo Arturo, Paul Haase, Franklin, Moreira Diaz, Juan Pablo, Ramirez Roca, Luis Alberto, Sanchez Arenales, Jose Antonio, Sanchez Polo, Jose Vicente, Turcios Juarez, Erick, Csecsei, Gyongyi, Csiky, Botond, Danos, Peter, Deak, Laszlo, Dudas, Mihaly, Harcsa, Eleonora, Keltai, Katalin, Keresztesi, Sandor, Kiss, Konyves, Laszlo, Major, Lajos, Mileder, Margit, Molnar, Marta, Mucsi, Janos, Oroszlan, Tamas, Ory, Ivan, Paragh, Gyorgy, Peterfai, Eva, Petro, Gizella, Revesz, Katalin, Takacs, Robert, Vangel, Sandor, Vasas, Szilard, Zsom, Marianna, Abraham, Oomman, Bhushan, Raju Sree, Deepak, Dewan, Edwin, Fernando M., Gopalakrishnan, Natarajan, Gracious, Noble, Hansraj, Alva, Jain, Dinesh, Keshavamurthy, C. B., Khullar, Dinesh, Manisha, Sahay, Peringat, Jayameena, Prasad, Narayan, Satyanarayana, Rao K., Sreedhar, Reddy, Sreelatha, Melemadathil, Sudhakar, Bhimavarapu, Vyasam, Ramesh Chandra, Bonadonna, Riccardo, Castellino, Pietro, Ceriello, Antonio, Chiovato, Luca, De Cosmo, Salvatore, De Nicola, Luca, Derosa, Giuseppe, Di Carlo, Alberto, Di Cianni, Graziano, Frasca, Giovanni, Fuiano, Giorgio, Gambaro, Giovanni, Garibotto, Giacomo, Giorda, Carlo, Malberti, Fabio, Mandreoli, Marcora, Mannucci, Edoardo, Orsi, Emanuela, Piatti, Piermarco, Santoro, Domenico, Sasso, Ferdinando Carlo, Serviddio, Gaetano, Stella, Andrea, Trevisan, Roberto, Veronelli, Anna Maria, Zanoli, Luca, Akiyama, Hitoshi, Aoki, Hiromi, Asano, Akimichi, Iitsuka, Tadashi, Kajiyama, Shizuo, Kashine, Susumu, Kawada, Toshio, Kodera, Takamoto, Kono, Hiroshi, Koyama, Kazunori, Kumeda, Yasuro, Miyauchi, Shozo, Mizuyama, Kazuyuki, Niiya, Tetsuji, Oishi, Hiroko, Ota, Satoshi, Sakakibara, Terue, Takai, Masahiko, Tomonaga, Osamu, Tsujimoto, Mitsuru, Wada, Takashi, Wakasugi, Masakiyo, Wakida, Yasushi, Watanabe, Takayuki, Yamada, Masayo, Yanagida, Kazuhiro, Yanase, Toshihiko, and Yumita, Wataru

Subjects
Male, Risk, primary prevention, canagliflozin, clinical trial, diabetes mellitus, renal insufficiency, chronic, secondary prevention, renal insufficiency, Double-Blind Method, Original Research Articles, Humans, Sodium-Glucose Transporter 2 Inhibitors, Proportional Hazards Models, canagliflozin, clinical trial, diabetes mellitus, primary prevention, renal insufficiency, chronic, secondary prevention, Middle Aged, Placebo Effect, chronic, Treatment Outcome, Diabetes Mellitus, Type 2, Cardiovascular Diseases, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Kidney Failure, Chronic, Female
Abstract

Supplemental Digital Content is available in the text., Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67–0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49–0.94]) and secondary (HR, 0.85 [95% CI, 0.69–1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61–1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59–1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56–1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02065791.

Published
2019

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