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Your search keyword '"Valenzuela-Pérez, Lucía"' showing total 13 results
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13 results on '"Valenzuela-Pérez, Lucía"'

1. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH

Author

Khoury, Mireille, Guo, Qianqian, Furuta, Kunimaro, Correia, Cristina, Meroueh, Chady, Kim Lee, Hyun Se, Warasnhe, Khaled, Valenzuela-Pérez, Lucía, Mazar, Andrew P., Kim, Iljung, Noh, Yung-Kyun, Holmes, Heather, Romero, Michael F., Sussman, Caroline R., Pavelko, Kevin D., Islam, Shahidul, Bamidele, Adebowale O., Hirsova, Petra, Li, Hu, and Ibrahim, Samar H.

Published
2024
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2. Interleukin 21 Drives a Hypermetabolic State and CD4+ T-Cell–Associated Pathogenicity in Chronic Intestinal Inflammation

Author

Bamidele, Adebowale O., Mishra, Shravan K., Piovezani Ramos, Guilherme, Hirsova, Petra, Klatt, Emily E., Abdelrahman, Leena M., Sagstetter, Mary R., Davidson, Heidi M., Fehrenbach, Patrick J., Valenzuela-Pérez, Lucía, Kim Lee, Hyun Se, Zhang, Song, Aguirre Lopez, Abner, Kurdi, Ahmed T., Westphal, Maria S., Gonzalez, Michelle M., Gaballa, Joseph M., Kosinsky, Robyn Laura, Lee, Hee Eun, Smyrk, Thomas C., Bantug, Glenn, Gades, Naomi M., and Faubion, William A., Jr.

Published
2024
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4. Alteration of Gut Microbiota Composition in the Progression of Liver Damage in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Author

Zazueta, Alejandra, primary, Valenzuela-Pérez, Lucía, additional, Ortiz-López, Nicolás, additional, Pinto-León, Araceli, additional, Torres, Verónica, additional, Guiñez, Danette, additional, Aliaga, Nicolás, additional, Merino, Pablo, additional, Sandoval, Alexandra, additional, Covarrubias, Natalia, additional, Pérez de Arce, Edith, additional, Cattaneo, Máximo, additional, Urzúa, Alvaro, additional, Roblero, Juan Pablo, additional, Poniachik, Jaime, additional, Gotteland, Martín, additional, Magne, Fabien, additional, and Beltrán, Caroll Jenny, additional

Published
2024
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12. Mitochondrial RNA cytosolic leakage drives the SASP.

Author

Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Pérez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, and Passos JF

Abstract

Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (mtDNA) release and cGAS/STING pathway activation. Here, we demonstrate that mitochondrial RNA (mtRNA) also accumulates in the cytosol of senescent cells, activating RNA sensors RIG-I and MDA5, leading to MAVS aggregation and SASP induction. Inhibition of these RNA sensors significantly reduces SASP factors. Furthermore, BAX and BAK plays a key role in mtRNA leakage during senescence, and their deletion diminishes SASP expression in vitro and in a mouse model of Metabolic Dysfunction Associated Steatohepatitis (MASH). These findings highlight mtRNA's role in SASP regulation and its potential as a therapeutic target for mitigating age-related inflammation.

Published
2024
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