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2. International benchmarking of stage at diagnosis for six childhood solid tumours (the BENCHISTA project): a population-based, retrospective cohort study

Author

Aitken, Joanne, O'Neill, Leisa, Youlden, Danny, Hackl, Monika, Ladenstein, Ruth, Van Eycken, Elizabeth, Van Damme, Nancy, Frazier, Lindsay, De Camargo, Beatriz, de Oliveira Santos, Marceli, Lima, Carlos A., Ramos, Walmiro, Cabral Formigosa, Lucrecia Aline, Ferreira dos Santos, Luciana, Casale, Claudina Agnese, Patrus Pena, Gil, Natívio, Juliana, Asturian Laporte, Cyntia, Santos de Menezes Miranda, Cristiana, Bastos Daniel, Cristiane, Nonata de Paulo, Raimunda, Veneziano, Donaldo B., Pontes de Aquino, Angela, Fernandes de Souza, Paulo Cesar, Valentim Leite, Rebeca, Valerianova, Zdravka, Konstantinov, Dobrin, Gupta, Sumit, Pole, Jason D., Sekerija, Mario, Stary, Jan, Sterba, Jaroslav, Hjalgrim, Lisa L., Falck Winther, Jeanette, Paapsi, Keiu, Lacour, Brigitte, Desandes, Emmanuel, Clavel, Jacqueline, Poulalhon, Claire, Ressing, Meike, Truebenbach, Claudia, Spix, Claudia, Petridou, Eleni T., Bouka, Evdoxia, Jakab, Zsuzsanna, Garami, Miklos, Galasso, Rocco, Sampietro, Giuseppe, Vetrano, Francesco, Sessa, Marcella, Maule, Milena M., Sacerdote, Carlotta, Ballotari, Paola, De Santis, Emilia, Ferrante, Margherita, Ragusa, Rosalia, Mian, Michael, Boni, Luca, Rognoni, Magda, Amodio, Rosalba, Boschetti, Lorenza, Cuccaro, Francesco, Bruno, Danila, Russo, Antonio G., Gervasi, Federico, Gambino, Maria L., Borciani, Elisabetta, Michiara, Maria, Mangone, Lucia, Spagnoli, Gianbattista, Ferretti, Stefano, Falcini, Fabio, Spata, Eugenia, Manasse, Sonia, Coccia, Paola, Bella, Francesca, Caldarella, Adele, Intrieri, Teresa, Scuderi, Tiziana, Rizzello, Roberto V., Zorzi, Manuel, Guzzinati, Stefano, Murray, Deirdre, Matsuda, Tomohiro, Nakata, Kayo, Azzopardi, Miriam J., Børge Johannesen, Tom, Dahlen, Aina H., Zeller, Bernward, Kowalczyk, Jerzy, Raciborska, Anna, Ferreira, Ana M., Caldas, Gabriela, Bucurenci, Mihaela, Coza, Dana, Zadnik, Vesna, Lopez de Munain, Arantza, Almela-Vich, Fernando, Jeghalef-El Karoui, Noura, Marcos-Gragera, Rafael, José Sanchez, Maria, Aragonés, Nuria, Parra-Blázquez, David, Chirlaque, Maria Dolores, Guevara, Marcela, Pardo, Elena, Peris-Bonet, Rafael, Cañete Nieto, Adela, Carulla, Marià, Lähteenmäki, Päivi, Kuehni, Claudia E., Redmond, Shelagh M., Visser, Otto, Karim-Kos, Henrike, Stevens, Sarah, Irvine, Lucy, Stiller, Charles, Gavin, Anna, Fitzpatrick, Deirdre, Bennet, Damien, Morrison, David S., Smith, Karen, Huws, Dyfed Wyn, Smits, Stephanie, Gaspar, Nathalie, Spreafico, Filippo, Bailey, Simon, Klein, Méric, Di Cataldo, Andrea, Capocaccia, Riccardo, Polanco, Angela, Green, Giles, Botta, Laura, Didonè, Fabio, Lopez-Cortes, Angela, Nieto, Adela Cañete, Hjalgrim, Lisa L, Stiller, Charles A, Gatta, Gemma, and Pritchard-Jones, Kathy

Published
2025
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3. Hypothermia After Cardiac Arrest in Large Animals (HACA-LA): Study protocol of a randomized controlled experimental trial

Author

Olof Persson, Anna Valerianova, Jan Bělohlávek, Tobias Cronberg, Niklas Nielsen, Elisabet Englund, Mikuláš Mlček, and Hans Friberg

Subjects
Cardiac arrest, Hypothermia, Temperature control, Functional outcome, Swine, Specialties of internal medicine, RC581-951
Abstract

Background: Induced hypothermia post-cardiac arrest is neuroprotective in animal experiments, but few high-quality studies have been performed in larger animals with human-like brains. The neuroprotective effect of postischemic hypothermia has recently been questioned in human trials. Our aim is to investigate whether hypothermia post-cardiac arrest confers a benefit compared to normothermia in large adult animals. Our hypothesis is that induced hypothermia post cardiac arrest is neuroprotective and that the effect diminishes when delayed two hours. Methods: Adult female pigs were anesthetized, mechanically ventilated and kept at baseline parameters including normothermia (38 °C). All animals were subjected to ten minutes of cardiac arrest (no-flow) by induced ventricular fibrillation, followed by four minutes of cardiopulmonary resuscitation with mechanical compressions, prior to the first countershock. Animals with sustained return of spontaneous circulation (systolic blood pressure >60 mmHg for ten minutes) within fifteen minutes from start of life support were included and randomized to three groups; immediate or delayed (2 h) intravenous cooling, both targeting 33 °C, or intravenously controlled normothermia (38 °C). Temperature control was applied for thirty hours including cooling time, temperature at target and controlled rewarming (0.5 °C/h). Animals were extubated and kept alive for seven days. The primary outcome measure is histological brain injury on day seven. Secondary outcomes include neurological and neurocognitive recovery, and the trajectory of biomarkers of brain injury. Conclusion: High-quality animal experiments in clinically relevant large animal models are necessary to close the gap of knowledge regarding neuroprotective effects of induced hypothermia after cardiac arrest.Trial registration: Preclinicaltrials.eu (PCTE0000272), published 2021-11-03.

Published
2024
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4. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study

Author

Turella, S., Dankiewicz, J., Ben-Hamouda, N., Nilsen, KB, Düring, J., Endisch, C., Engstrøm, M., Flügel, D., Gaspard, N., Grejs, A.M., Haenggi, M., Haffey, S., Imbach, L., Johnsen, B., Kemlink, D., Leithner, C., Legriel, S., Lindehammar, H., Mazzon, G., Nielsen, N., Peyre, A., Ribalta Stanford, B., Roman-Pognuz, E., Rossetti, A.O., Schrag, C., Valeriánová, A., Wendel-Garcia, P., Zubler, F., Cronberg, T., and Westhall, E.

Published
2024
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5. Long-term survival for lymphoid neoplasms and national health expenditure (EUROCARE-6): a retrospective, population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Eberle, Andrea, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M, Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Cerza, Francesco, Di Mari, Fabrizio, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Rollo, Concetta Patrizia, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Ferreira, Ana Maia, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, María Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Paapsi, Keiu, Mousavi, Seyed Mohsen, and Sánchez, Maria-Jose

Published
2024
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6. Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

Author

Hackl, Monika, Van Eycken, Elizabeth, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Scoutellas, Vasos, Demetriou, Anna, Dušek, Ladislav, Krejici, Denisa, Storm, Hans, Mägi, Margit, Innos, Kaire, Pitkäniemi, Janne, Velten, Michel, Troussard, Xavier, Bouvier, Anne-Marie, Jooste, Valerie, Guizard, Anne-Valérie, Launoy, Guy, Dabakuyo Yonli, Sandrine, Maynadié, Marc, Woronoff, Anne-Sophie, Nousbaum, Jean-Baptiste, Coureau, Gaëlle, Monnereau, Alain, Baldi, Isabelle, Hammas, Karima, Tretarre, Brigitte, Colonna, Marc, Plouvier, Sandrine, D'Almeida, Tania, Molinié, Florence, Cowppli-Bony, Anne, Bara, Simona, Debreuve, Adeline, Defossez, Gautier, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Daubisse-Marliac, Laetitia, Luttmann, Sabine, Stabenow, Roland, Nennecke, Alice, Kieschke, Joachim, Zeissig, Sylke, Holleczek, Bernd, Katalinic, Alexander, Birgisson, Helgi, Murray, Deirdre, Walsh, Paul M., Mazzoleni, Guido, Vittadello, Fabio, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Rosso, Stefano, Gasparotti, Cinzia, Maifredi, Giovanni, Ferrante, Margherita, Ragusa, Rosalia, Sutera Sardo, Antonella, Gambino, Maria Letizia, Lanzoni, Monica, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Caldarella, Adele, Manneschi, Gianfranco, Gatta, Gemma, Sant, Milena, Baili, Paolo, Berrino, Franco, Botta, Laura, Trama, Annalisa, Lillini, Roberto, Bernasconi, Alice, Bonfarnuzzo, Simone, Vener, Claudia, Didonè, Fabio, Lasalvia, Paolo, Buratti, Lucia, Tagliabue, Giovanna, Serraino, Diego, Dal Maso, Luigino, Capocaccia, Riccardo, De Angelis, Roberta, Demuru, Elena, Di Benedetto, Corrado, Rossi, Silvia, Santaquilani, Mariano, Venanzi, Serenella, Tallon, Marco, Boni, Luca, Iacovacci, Silvia, Gennaro, Valerio, Russo, Antonio Giampiero, Gervasi, Federico, Spagnoli, Gianbattista, Cavalieri d'Oro, Luca, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Mazzucco, Walter, Michiara, Maria, Chiranda, Giorgio, Cascone, Giuseppe, Giurdanella, Maria Concetta, Mangone, Lucia, Falcini, Fabio, Cavallo, Rossella, Piras, Daniela, Madeddu, Anselmo, Bella, Francesca, Fanetti, Anna Clara, Minerba, Sante, Candela, Giuseppina, Scuderi, Tiziana, Rizzello, Roberto Vito, Stracci, Fabrizio, Rugge, Massimo, Brustolin, Angelita, Pildava, Santa, Smailyte, Giedre, Azzopardi, Miriam, Johannesen, Tom Børge, Didkowska, Joanna, Wojciechowska, Urszula, Bielska-Lasota, Magdalena, Pais, Ana, Bento, Maria José, Calisto, Rita, Lourenço, António, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, Sánchez-Contador Escudero, Carmen, Franch Sureda, Paula, Lopez de Munain, Arantza, De-La-Cruz, Marta, Rojas, Marìa Dolores, Aleman, Araceli, Vizcaino, Ana, Marcos-Gragera, Rafael, Sanvisens, Arantza, Sanchez, Maria Josè, Chirlaque Lopez, Maria Dolores, Sanchez-Gil, Antonia, Guevara, Marcela, Ardanaz, Eva, Galceran, Jaume, Carulla, Maria, Bergeron, Yvan, Bouchardy, Christine, Mohsen Mousavi, Seyed, Went, Philip, Blum, Marcel, Bordoni, Andrea, Visser, Otto, Stevens, Sarah, Broggio, John, Bennett, Damien, Gavin, Anna, Morrison, David, Huws, Dyfed Wyn, Ventura, Leonardo, Paapsi, Keiu, Randi, Giorgia, Bettio, Manola, and Guzzinati, Stefano

Published
2024
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7. Novel PD-L1- and collagen-expressing patient-derived cell line of undifferentiated pleomorphic sarcoma (JBT19) as a model for cancer immunotherapy

Author

Pavla Taborska, Pavol Lukac, Dmitry Stakheev, Lenka Rajsiglova, Katerina Kalkusova, Karolina Strnadova, Lukas Lacina, Barbora Dvorankova, Jiri Novotny, Michal Kolar, Milena Vrana, Hana Cechova, Sarka Ransdorfova, Marie Valerianova, Karel Smetana, Luca Vannucci, and Daniel Smrz

Subjects
Medicine, Science
Abstract

Abstract Soft tissue sarcomas are aggressive mesenchymal-origin malignancies. Undifferentiated pleomorphic sarcoma (UPS) belongs to the aggressive, high-grade, and least characterized sarcoma subtype, affecting multiple tissues and metastasizing to many organs. The treatment of localized UPS includes surgery in combination with radiation therapy. Metastatic forms are treated with chemotherapy. Immunotherapy is a promising treatment modality for many cancers. However, the development of immunotherapy for UPS is limited due to its heterogeneity, antigenic landscape variation, lower infiltration with immune cells, and a limited number of established patient-derived UPS cell lines for preclinical research. In this study, we established and characterized a novel patient-derived UPS cell line, JBT19. The JBT19 cells express PD-L1 and collagen, a ligand of the immune checkpoint molecule LAIR-1. JBT19 cells can form spheroids in vitro and solid tumors in immunodeficient nude mice. We found JBT19 cells induce expansion of JBT19-reactive autologous and allogeneic NK, T, and NKT-like cells, and the reactivity of the expanded cells was associated with cytotoxic impact on JBT19 cells. The PD-1 and LAIR-1 ligand-expressing JBT19 cells show ex vivo immunogenicity and effective in vivo xenoengraftment properties that can offer a unique resource in the preclinical research developing novel immunotherapeutic interventions in the treatment of UPS.

Published
2023
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9. Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage

Author

Angela Lopez-Cortes, Fabio Didonè, Laura Botta, Lisa L. Hjalgrim, Zsuzsanna Jakab, Adela Cañete Nieto, Charles Stiller, Bernward Zeller, Gemma Gatta, Kathy Pritchard-Jones, The BENCHISTA Project Working Group, Joanne Aitken, Leisa O’Neil, Monika Hack, Ruth Ladenstein, Elizabeth Van Eycken, Nancy Van Damme, Lindsay Frazier, Beatriz De Camargo, Marceli de Oliveira Santos, Zdravka Valerianova, Dobrin Konstantinov, Sumit Gupta, Jason D Pole, Mario Sekerija, Jan Stary, Jaroslav Sterba, Jeanette F Winther, Keiu Paapsi, Brigitte Lacour, Emmanuel Desandes, Jacqueline Clavel, Claire Poulalhon, Friederike Erdmann, Eleni T Petridou, Evdoxia Bouka, Michael Mian, Rocco Galasso, Giuseppe Sampietro, Francesco Vetrano, Milena M Maule, Carlotta Sacerdote, Paola Ballotari, Emilia De Santis, Margherita Ferrante, Rosalia Ragusa, Luca Boni, Magda Rognoni, Rosalba Amodio, Lorenza Boschetti, Francesco Cuccaro, Danila Bruno, Antonio G Russo, Federico Gervasi, Maria L Gambino, Elisabetta Borciani, Maria Michiara, Lucia Mangone, Gianbattista Spagnoli, Stefano Ferretti, Fabio Falcini, Eugenia Spata, Sonia Manasse, Paola Coccia, Francesca Bella, Adele Caldarella, Teresa Intrieri, Tiziana Scuderi, Roberto V Rizzello, Massimo Rugge, Stefano Guzzinati, Deirdre Murray, Tomohiro Matsuda, Kayo Nakata, Miriam J Azzopardi, Aina H Dahlen, Johannesen Tom Børge, Jerzy Kowalczyk, Monika Jedrzejczyk, Gabriela Caldas, Mihaela Bucurenci, Dana Coza, Vesna Zadnik, Arantza Lopez de Munain, Fernando Almela-Vich, Nieves Fuster-Camarena, Ra f a e l Marcos-Gragera, Maria José Sanchez, Nuria Aragones, Raquel Lopez, Maria Dolores Chirlaque, Marcela Guevara, Elena Pardo, Rafael Peris-Bonet, Marià Carulla, Päivi Lähteenmäki, Claudia E Kuehni, Shelagh M Redmond, Henrike Karim-Kos, Paul Stacey, Lucy Irvine, Anna Gavin, Deirdre Fitzpatrick, David S Morrison, Karen Smith, Dyfed Wyn Huws, Janet Warlow, Sandra Strauss, Simon Bailey, Adela Canete Nieto, Nathalie Gaspar, Filippo Spreafico, Angela Polanco, Riccardo Capocaccia, Andrea Di Cataldo, and Meric Klein

Subjects
childhood cancer, population-based, cancer registry, Toronto staging, diagnosis, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionVariation in stage at diagnosis of childhood cancers (CC) may explain differences in survival rates observed across geographical regions. The BENCHISTA project aims to understand these differences and to encourage the application of the Toronto Staging Guidelines (TG) by Population-Based Cancer Registries (PBCRs) to the most common solid paediatric cancers.MethodsPBCRs within and outside Europe were invited to participate and identify all cases of Neuroblastoma, Wilms Tumour, Medulloblastoma, Ewing Sarcoma, Rhabdomyosarcoma and Osteosarcoma diagnosed in a consecutive three-year period (2014-2017) and apply TG at diagnosis. Other non-stage prognostic factors, treatment, progression/recurrence, and cause of death information were collected as optional variables. A minimum of three-year follow-up was required. To standardise TG application by PBCRs, on-line workshops led by six tumour-specific clinical experts were held. To understand the role of data availability and quality, a survey focused on data collection/sharing processes and a quality assurance exercise were generated. To support data harmonization and query resolution a dedicated email and a question-and-answers bank were created.Results67 PBCRs from 28 countries participated and provided a maximally de-personalized, patient-level dataset. For 26 PBCRs, data format and ethical approval obtained by the two sponsoring institutions (UCL and INT) was sufficient for data sharing. 41 participating PBCRs required a Data Transfer Agreement (DTA) to comply with data protection regulations. Due to heterogeneity found in legal aspects, 18 months were spent on finalizing the DTA. The data collection survey was answered by 68 respondents from 63 PBCRs; 44% of them confirmed the ability to re-consult a clinician in cases where stage ascertainment was difficult/uncertain. Of the total participating PBCRs, 75% completed the staging quality assurance exercise, with a median correct answer proportion of 92% [range: 70% (rhabdomyosarcoma) to 100% (Wilms tumour)].ConclusionDifferences in interpretation and processes required to harmonize general data protection regulations across countries were encountered causing delays in data transfer. Despite challenges, the BENCHISTA Project has established a large collaboration between PBCRs and clinicians to collect detailed and standardised TG at a population-level enhancing the understanding of the reasons for variation in overall survival rates for CC, stimulate research and improve national/regional child health plans.

Published
2023
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10. Comparing the hemodynamic effect of a large arteriovenous fistula during high and low cardiac output states

Author

A. Valerianova, M. Mlcek, J. Malik, T. Grus, L. Tejkl, B. Kolosova, V. Lejsek, and O. Kittnar

Subjects
arteriovenous fistula, hyperkinetic circulation, dobutamine, norepinephrine, low cardiac output, Physiology, QP1-981
Abstract

Background: A large arteriovenous fistula (AVF) is a low-resistant circuit that affects organ perfusion and systemic hemodynamics even in standard conditions. The extent of its’ effect in critical states has not been elucidated yet. We used norepinephrine to create systemic vasoconstriction, dobutamine to create high cardiac output, and rapid right ventricle pacing as a model of acute heart failure in a porcine model of high-flow AVF circulation.Methods: The protocol was performed on nine domestic female pigs under general anesthesia. AVF was created by connecting two high-diameter ECMO cannulas inserted in the femoral artery and vein. Continuous hemodynamic monitoring was performed throughout the protocol. Three interventions were performed–moderate dose of norepinephrine (0.25 ug/kg/min), moderate dose of dobutamine (10 ug/kg/min) and rapid right ventricle pacing to simulate low cardiac output state with mean arterial pressure under 60 mmHg. Measurements were taken with opened and closed arteriovenous fistula.Results: Continuous infusion of norepinephrine with opened AVF significantly increased mean arterial pressure (+20%) and total cardiac output (CO) (+36%), but vascular resistance remained virtually unchanged. AVF flow (Qa) rise correlated with mean arterial pressure increase (+20%; R = 0.97, p = 0.0001). Effective cardiac output increased, leading to insignificant improvement in organ perfusion. Dobutamine substantially increased cardiac output with insignificant effect on AVF flow and mean arterial pressure. Carotid artery blood flow increased significantly after dobutamine infusion by approximately 30%, coronary flow velocity increased significantly only in closed AVF state. The effective cardiac output using the heart failure model leading to decrease of carotid artery flow and worsening of brain and peripheral tissue oximetry. AVF blood flow also dropped significantly and proportionally to pressure, but Qa/CO ratio did not change. Therefore, the effective cardiac output decreased.Conclusion: In abovementioned extreme hemodynamic conditions the AVF flow was always directly proportional to systemic perfusion pressure. The ratio of shunt flow to cardiac output depended on systemic vascular resistance. These experiments highlight the detrimental role of a large AVF in these critical conditions’ models.

Published
2023
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11. A large arteriovenous fistula steals a considerable part of systemic blood flow during veno-arterial extracorporeal circulation support in a porcine model

Author

A. Valerianova, M. Mlcek, O. Kittnar, T. Grus, L. Tejkl, V. Lejsek, and J. Malik

Subjects
animal model, veno-arterial extracorporeal membrane oxygenation, arteriovenous fistula, cerebral blood flow, cerebral tissue oxygenation, Physiology, QP1-981
Abstract

Background: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is one of the most frequently used mechanical circulatory support devices. Distribution of extracorporeal membrane oxygenation flow depends (similarly as the cardiac output distribution) on regional vascular resistance. Arteriovenous fistulas (AVFs), used frequently as hemodialysis access, represent a low-resistant circuit which steals part of the systemic perfusion. We tested the hypothesis that the presence of a large Arteriovenous fistulas significantly changes organ perfusion during a partial and a full Veno-arterial extracorporeal membrane oxygenation support.Methods: The protocol was performed on domestic female pigs held under general anesthesia. Cannulas for Veno-arterial extracorporeal membrane oxygenation were inserted into femoral artery and vein. The Arteriovenous fistulas was created using another two high-diameter extracorporeal membrane oxygenation cannulas inserted in the contralateral femoral artery and vein. Catheters, flow probes, flow wires and other sensors were placed for continuous monitoring of haemodynamics and organ perfusion. A stepwise increase in extracorporeal membrane oxygenation flow was considered under beating heart and ventricular fibrillation (VF) with closed and opened Arteriovenous fistulas.Results: Opening of a large Arteriovenous fistulas (blood flow ranging from 1.1 to 2.2 L/min) resulted in decrease of effective systemic blood flow by 17%–30% (p < 0.01 for all steps). This led to a significant decrease of carotid artery flow (ranging from 13% to 25% after Arteriovenous fistulas opening) following VF and under partial extracorporeal membrane oxygenation support. Cerebral tissue oxygenation measured by near infrared spectroscopy also decreased significantly in all steps. These changes occurred even with maintained perfusion pressure. Changes in coronary artery flow were driven by changes in the native cardiac output.Conclusion: A large arteriovenous fistula can completely counteract Veno-arterial extracorporeal membrane oxygenation support unless maximal extracorporeal membrane oxygenation flow is applied. Cerebral blood flow and oxygenation are mainly compromised by the effect of the Arteriovenous fistulas. These effects could influence brain function in patients with Arteriovenous fistulas on Veno-arterial extracorporeal membrane oxygenation.

Published
2023
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12. Heart failure with preserved ejection fraction is the most frequent but commonly overlooked phenotype in patients on chronic hemodialysis

Author

Jan Malik, Anna Valerianova, Satu Sinikka Pesickova, Kristyna Michalickova, Zuzana Hladinova, Zdenka Hruskova, Vladimira Bednarova, Katarina Rocinova, Monika Tothova, Marketa Kratochvilova, Lucie Kaiserova, Kristina Buryskova Salajova, Vaclav Lejsek, Martin Sevcik, and Vladimir Tesar

Subjects
heart failure, end-stage renal disease, HFPEF, high-output heart failure, echocardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionHeart failure (HF) is a serious complication of end-stage kidney disease (ESKD). However, most data come from retrospective studies that included patients on chronic hemodialysis at the time of its initiation. These patients are frequently overhydrated, which significantly influences the echocardiogram findings. The primary aim of this study was to analyze the prevalence of heart failure and its phenotypes. The secondary aims were (1) to describe the potential of N-terminal pro-brain natriuretic peptide (NTproBNP) for HF diagnosis in ESKD patients on hemodialysis, (2) to analyze the frequency of abnormal left ventricular geometry, and (3) to describe the differences between various HF phenotypes in this population.MethodsWe included all patients on chronic hemodialysis for at least 3 months from five hemodialysis units who were willing to participate, had no living kidney transplant donor, and had a life expectancy longer than 6 months at the time of inclusion. Detailed echocardiography together with hemodynamic calculations, dialysis arteriovenous fistula flow volume calculation, and basic lab analysis were performed in conditions of clinical stability. Excess of severe overhydration was excluded by clinical examination and by employing bioimpedance.ResultsA total of 214 patients aged 66.4 ± 14.6 years were included. HF was diagnosed in 57% of them. Among patients with HF, HF with preserved ejection fraction (HFpEF) was, by far, the most common phenotype and occurred in 35%, while HF with reduced ejection fraction (HFrEF) occurred only in 7%, HF with mildly reduced ejection fraction (HFmrEF) in 7%, and high-output HF in 9%. Patients with HFpEF differed from patients with no HF significantly in the following: they were older (62 ± 14 vs. 70 ± 14, p = 0.002) and had a higher left ventricular mass index [96(36) vs. 108(45), p = 0.015], higher left atrial index [33(12) vs. 44(16), p

Published
2023
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14. Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000–14 (CONCORD-3): analysis of individual data from 258 cancer registries in 61 countries

Author

Bouzbid, Sabiha, Hamdi-Chérif, Mokhtar, Kara, Lamia, Meguenni, Kaouel, Regagba, Derbali, Bayo, Sine, Cheick Bougadari, Traore, Manraj, Shyam Shunker, Bendahhou, Karima, Ladipo, Akinade, Ogunbiyi, Olufemi, Somdyala, Nontuthuzelo, Chaplin, María Agustina, Moreno, Florencia, Calabrano, Gladis, Espinola, Silvia, Carballo Quintero, Beatriz, Fita, Rosalba, Laspada, Walter, Ibañez, Susana, Lima, Carlos, Mafra Da Costa, Allini, De Souza, Paulo César, Chaves, Juliana, Laporte, Cyntia, Curado, Maria Paula, de Oliveira, Jose Carlos, Veneziano, Claudia, Veneziano, Donaldo, Almeida, Ana Beatriz, Latorre, Maria, Azevedo e Silva, Gulnar, Rebelo, Marise, Santos, Marceli, Galaz, Juan, Aparicio Aravena, Mackarena, Sanhueza Monsalve, Jocelyn, Herrmann, Denise, Vargas, Solange, Herrera, Victor, Uribe, Claudia, Bravo, Luis Eduardo, Garcia, Luz Stella, Arias-Ortiz, Nelson, Morantes, Daniela, Jurado, Daniel, Yépez Chamorro, María, Delgado, Sandra, Ramirez, Melissa, Galán Alvarez, Yaima, Torres, Priscila, Martínez-Reyes, Fray, Jaramillo, Leyda, Quinto, Rina, Castillo, Jhoanna, Mendoza, Mariela, Cueva, Patricia, Yépez, José, Bhakkan, Bernard, Deloumeaux, Jacqueline, Joachim, Clarisse, Macni, Jonathan, Carrillo, Rodolfo, Shalkow Klincovstein, Jaime, Rivera Gomez, Rebeca, Perez, Patricia, Poquioma, Ebert, Tortolero-Luna, Guillermo, Zavala, Diego, Alonso, Rafael, Barrios, Enrique, Eckstrand, Angela, Nikiforuk, Cindy, Woods, Ryan, Noonan, Gail, Turner, Donna, Kumar, Eshwar, Zhang, Bin, Dowden, Jeff, Doyle, Gregory, Saint-Jacques, Nathalie, Walsh, Gordon, Anam, Aniq, De, Prithwish, McClure, Carol, Vriends, Kim, Bertrand, Christine, Ramanakumar, Agnihotram, Kozie, Serena, Stuart-Panko, Heather, Freeman, Tara, George, Justin, Avila, Rosa, O'Brien, David, Holt, Abby, Almon, Lyn, Ward, Kevin, Kwong, Sandy, Morris, Cyllene, Rycroft, Randi, Mueller, Lloyd, Phillips, Cathryn, Brown, Heather, Cromartie, Betsy, Ruterbusch, Julie, Schwartz, Ann, Levin, Gary, Wohler, Brad, Bayakly, Rana, Gomez, Scarlett, McKinley, Meg, Cress, Rosemary, Davis, Joni, Hernandez, Brenda, Johnson, Christopher, Morawski, Bozena, Ruppert, Laura, Bentler, Suzanne, Charlton, Mary, Huang, Bin, Tucker, Thomas, Deapen, Dennis, Liu, Lihua, Hsieh, Mei-Chin, Wu, Xiao-Cheng, Schwenn, Molly, Stern, Kimberly, Gershman, Susan, Knowlton, Richard, Alverson, Georgetta, Weaver, Tamara, Desai, Jay, Rogers, Deirdre, Jackson-Thompson, Jeanette, Lemons, Debbi, Zimmerman, Heather, Hood, Michelle, Roberts-Johnson, Jenifer, Hammond, Whitney, Rees, Judith, Pawlish, Karen, Stroup, Antoinette, Key, Charles, Wiggins, Charles, Kahn, Amy, Schymura, Maria, Radhakrishnan, Soundarya, Rao, Chandrika, Giljahn, Lynn, Slocumb, Roberta, Dabbs, Christy, Espinoza, Raffaella, Aird, Karen, Beran, Todd, Rubertone, Jim, Slack, Stephen, Oh, Junhie, Janes, Tiffany, Schwartz, Stephen, Chiodini, Stephanie, Hurley, Deborah, Whiteside, Martin, Rai, Saroj, Williams, Melanie, Herget, Kim, Sweeney, Carol, Johnson, Alison, Keitheri Cheteri, Mahesh, Migliore Santiago, Patti, Blankenship, Steven, Farley, Shawn, Borchers, Robert, Malicki, Robin, Espinoza, Julia, Grandpre, Joseph, Edwards, Brenda, Mariotto, Angela, Weir, Hannah, Wilson, Reda, Wang, Ning, Yang, Lei, Chen, Jian-Shun, He, Yu-Tong, Song, Guo-Hui, Gu, Xiao-Ping, Mei, Dan, Ge, Heng-Ming, Wu, Tong-Hao, Li, Yan-Yan, Zhao, De-Li, Jin, Feng, Zhang, Jian-Hua, Zhu, Feng-Dong, Junhua, Qian, Yang, Yan Lei, Jiang, Chun-Xiao, Biao, Wang, Wang, Jian, Li, Qi-Long, Yi, He, Zhou, Xin, Dong, JianMei, Li, WeiWei, Fu, Fang-Xian, Chen, Jian-Guo, Zhu, Jian, Li, Yan-Hua, Lu, Yu-Qiang, Fan, Min, Huang, Su-Qin, Guo, Guo-Ping, Zhaolai, Hua, Wei, Kuangrong, Chen, Wan-Qing, Wei, Wenqiang, Zeng, Hongmei, Demetriou, Anna, Mang, Wai Kong, Ngan, Kai Cheong, Kataki, Amal, Krishnatreya, Manigreeva, Jayalekshmi, Padmavathi Amma, Sebastian, Paul, George, Preethi, Mathew, Aleyamma, Nandakumar, Ambakumar, Malekzadeh, Reza, Roshandel, Gholamreza, Keinan-Boker, Lital, Silverman, Barbara, Ito, Hidemi, Koyanagi, Yuriko, Sato, Masako, Tobori, Fumio, Nakata, Ichiro, Teramoto, Norihiro, Hattori, Masakazu, Kaizaki, Yasuharu, Moki, Fumitaka, Sugiyama, Hiromi, Utada, Mai, Nishimura, Makiko, Yoshida, Keiichi, Kurosawa, Katsuki, Nemoto, Yuji, Narimatsu, Hiroto, Sakaguchi, Masahiko, Kanemura, Seiki, Naito, Michiko, Narisawa, Rintaro, Miyashiro, Isao, Nakata, Kayo, Mori, Daisuke, Yoshitake, Mayuko, Oki, Izumi, Fukushima, Norimasa, Shibata, Akiko, Iwasa, Keiichiro, Ono, Chie, Matsuda, Tomohiro, Nimri, Omar, Jung, Kyu-Won, Won, Young-Joo, Alawadhi, Eiman, Elbasmi, Amani, Ab Manan, Azizah, Adam, Farzaana, Nansalmaa, Erdenekhuu, Tudev, Undarmaa, Ochir, Chimedsuren, Al Khater, Al Hareth, El Mistiri, Mufid, Lim, Gek Hsiang, Teo, Yik Ying, Chiang, Chun-Ju, Lee, Wen-Chung, Buasom, Rangsiya, Sangrajrang, Suleeporn, Suwanrungruang, Krittika, Vatanasapt, Patravoot, Daoprasert, Karnchana, Pongnikorn, Donsuk, Leklob, Atit, Sangkitipaiboon, Somphob, Geater, Sarayut, Sriplung, Hutcha, Ceylan, Okan, Kög, Iskender, Dirican, Oya, Köse, Tülay, Gurbuz, Tulın, Karašahin, Füsun Emine, Turhan, Duygu, Aktaş, Umut, Halat, Yakup, Eser, Sultan, Yakut, Cankut, Altinisik, Merve, Cavusoglu, Yasar, Türkköylü, Ayşe, Üçüncü, Nuršen, Hackl, Monika, Zborovskaya, Anna, Aleinikova, Olga, Henau, Kris, Van Eycken, Liesbet, Atanasov, Trayan, Valerianova, Zdravka, Šekerija, Mario, Dušek, Ladislav, Zvolský, Miroslav, Steinrud Mørch, Lina, Storm, Hans, Wessel Skovlund, Charlotte, Innos, Kaire, Mägi, Margit, Malila, Nea, Seppä, Karri, Jégu, Jérémie, Velten, Michel, Cornet, Edouard, Troussard, Xavier, Bouvier, Anne-Marie, Guizard, Anne-Valérie, Bouvier, Véronique, Launoy, Guy, Dabakuyo Yonli, Sandrine, Poillot, Marie-Laure, Maynadié, Marc, Mounier, Morgane, Vaconnet, Lina, Woronoff, Anne-Sophie, Daoulas, Mélanie, Robaszkiewicz, Michel, Clavel, Jacqueline, Poulalhon, Claire, Desandes, Emmanuel, Lacour, Brigitte, Baldi, Isabelle, Pouchieu, Camille, Amadeo, Brice, Coureau, Gaëlle, Monnereau, Alain, Audoin, Magali, D'Almeida, Tania, Boyer, Séverine, Hammas, Karima, Trétarre, Brigitte, Colonna, Marc, Delafosse, Patricia, Plouvier, Sandrine, Cowppli-Bony, Anne, Molinié, Florence, Bara, Simona, Ganry, Olivier, Lapôtre-Ledoux, Bénédicte, Daubisse-Marliac, Laetitia, Bossard, Nadine, Estève, Jacques, Uhry, Zoé, Stabenow, Roland, Wilsdorf-Köhler, Heide, Eberle, Andrea, Luttmann, Sabine, Löhden, Imma, Nennecke, Alice, Kieschke, Joachim, Sirri, Eunice, Justenhoven, Christina, Zeissig, Sylke, Holleczek, Bernd, Eisemann, Nora, Katalinic, Alexander, Asquez, Rachelle, Kumar, Vijay, Petridou, Eleni, Ólafsdóttir, Elínborg, Tryggvadóttir, Laufey, Murray, Deirdre, Walsh, Paul, Sundseth, Hildrun, Mazzoleni, Guido, Vittadello, Fabio, Coviello, Enzo, Cuccaro, Francesco, Galasso, Rocco, Sampietro, Giuseppe, Magoni, Michele, Ardizzone, Antonino, D'Argenzio, Angelo, Di Prima, Alessia Anna, Ippolito, Antonella, Lavecchia, Anna Maria, Sutera Sardo, Antonella, Gola, Gemma, Ballotari, Paola, Giacomazzi, Erica, Ferretti, Stefano, Dal Maso, Luigino, Serraino, Diego, Celesia, Maria Vittoria, Filiberti, Rosa Angela, Pannozzo, Fabio, Melcarne, Anna, Quarta, Fabrizio, Andreano, Anita, Russo, Antonio Giampiero, Carrozzi, Giuliano, Cirilli, Claudia, Cavalieri d'Oro, Luca, Rognoni, Magda, Fusco, Mario, Vitale, Maria Francesca, Usala, Mario, Cusimano, Rosanna, Mazzucco, Walter, Michiara, Maria, Sgargi, Paolo, Boschetti, Lorenza, Chiaranda, Giorgio, Seghini, Pietro, Maule, Milena, Merletti, Franco, Spata, Eugenia, Tumino, Rosario, Mancuso, Pamela, Vicentini, Massimo, Cassetti, Tiziana, Sassatelli, Romano, Falcini, Fabio, Giorgetti, Stefania, Caiazzo, Anna Luisa, Cavallo, Rossella, Piras, Daniela, Bella, Francesca, Madeddu, Anselmo, Fanetti, Anna Clara, Maspero, Sergio, Carone, Simona, Mincuzzi, Antonia, Candela, Giuseppa, Scuderi, Tiziana, Gentilini, Maria Adalgisa, Rizzello, Roberto, Rosso, Stefano, Zanetti, Roberto, Caldarella, Adele, Intrieri, Teresa, Bianconi, Fortunato, Stracci, Fabrizio, Contiero, Paolo, Tagliabue, Giovanna, Rugge, Massimo, Zorzi, Manuel, Beggiato, Simonetta, Brustolin, Angelita, De Angelis, Roberta, Gatta, Gemma, Maurina, Anita, Oniščuka, Marija, Mousavi, Mohsen, Lipunova, Nadezda, Vincerzevskienė, Ieva, Agius, Dominic, Calleja, Neville, Siesling, Sabine, Visser, Otto, Johannesen, Tom, Larønningen, Siri, Trojanowski, Maciej, Mierzwa, Tomasz, Rachtan, Jadwiga, Kępska, Kamila, Kościańska, Beata, Wójcik-Tomaszewska, Joanna, Motnyk, Marcin, Gos, Anna, Bielska-Lasota, Magdalena, Didkowska, Joanna, Wojciechowska, Urszula, Forjaz de Lacerda, Gonçalo, Rego, Raul, Carrito, Branca, Pais, Ana, Bento, Maria José, Rodrigues, Jessica, Lourenço, Antonio, Mayer-da-Silva, Alexandra, Blaga, Luminita, Coza, Daniela, Valkov, Mikhail, Gusenkova, Lubov, Lazarevich, Olga, Prudnikova, Olga, Vjushkov, Dmitri Mikhailovich, Egorova, Alla, Orlov, Andrey, Pikalova, Lidiya, Zhuikova, Lilia, Adamcik, Juraj, Safaei Diba, Chakameh, Zadnik, Vesna, Zagar, Tina, De-La-Cruz, Marta, Lopez-de-Munain, Arantza, Aleman, Araceli, Rojas, Dolores, Chillarón, Rosario Jiménez, Navarro, Ana Isabel Marcos, Marcos-Gragera, Rafael, Puigdemont, Montse, Rodríguez-Barranco, Miguel, Sánchez Perez, María-José, Franch Sureda, Paula, Ramos Montserrat, Maria, Chirlaque López, Maria Dolores, Sánchez Gil, Antonia, Ardanaz, Eva, Guevara, Marcela, Cañete-Nieto, Adela, Peris-Bonet, Rafael, Carulla, Marià, Galceran, Jaume, Almela, Fernando, Sabater, Consol, Khan, Staffan, Pettersson, David, Dickman, Paul, Staehelin, Katharina, Struchen, Benjamin, Herrmann, Christian, Mousavi, Seyed Mohsen, Egger Hayoz, Céline, Bouchardy, Christine, Schaffar, Robin, Went, Philip, Bulliard, Jean-Luc, Maspoli-Conconi, Manuela, Kuehni, Claudia, Redmond, Shelagh, Bordoni, Andrea, Ortelli, Laura, Chiolero, Arnaud, Konzelmann, Isabelle, Rohrmann, Sabine, Wanner, Miriam, Broggio, John, Rashbass, Jem, Stiller, Charles, Fitzpatrick, Deirdre, Gavin, Anna, Morrison, David, Thomson, Catherine, Greene, Giles, Huws, Dyfed, Allemani, Claudia, Coleman, Michel, Di Carlo, Veronica, Girardi, Fabio, Matz, Melissa, Minicozzi, Pamela, Sanz, Natalia, Ssenyonga, Naomi, Stephens, Richard, Chalker, Elizabeth, Smith, Mirka, Gugusheff, Jessica, You, Hui, Qin Li, Shu, Dugdale, Sarah, Moore, Julie, Philpot, Shoni, Pfeiffer, Rhonda, Thomas, Helen, Silva Ragaini, Bruna, Venn, Alison, Evans, Sue, Te Marvelde, Luc, Savietto, Vedrana, Trevithick, Richard, Currow, David, Fowler, Christine, Lewis, Chris, Shalkow, Jaime, Bonaventure, Audrey, Wyn Huws, Dyfed, and Coleman, Michel P

Published
2022
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15. Availability of technology for managing cancer patients in the Southeast European (SEE) region

Author

Dosanjh, Manjit, Ristova, Mimoza, Gershan, Vesna, Georgieva, Petya, Balin Kovacevic, Marijana, Bregu, Ledio, Coralic, Irma, Djurovic, Tamara, Dosieva, Deyana, Foka, Yiota, Fröbe, Ana, Hatziioannou, Konstantinos, Hourdakis, Costas J., Kabashi, Yllka, Kalev, Dimitar, Kurtishi, Ilir, Litov, Leandar, Mezelxhiu, Beqir, Nestoroska Madjunarova, Svetlana, Nikolova, Gordana, Skrk, Damijan, Smajlbegovic, Velda, Smichkoska, Snezana, Stojkovski, Igor, Strojan, Primož, Tecic, Zdravka, Tešanović, Dušanka, Todorovic, Vladimir, and Valerianova, Zdravka

Published
2022
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17. Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes

Author

Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis, the EUROCARE-6 Working Group, M. Hackl, E. Van Eycken, N. Van Damme, Z. Valerianova, M. Sekerija, V. Scoutellas, A. Demetriou, L. Dušek, D. Krejici, H. Storm, M. Mägi, K. Innos, N. Malila, J. Pitkäniemi, M. Velten, X. Troussard, A.M. Bouvier, V. Jooste, A.V. Guizard, S. Dabakuyo Yonli, M. Maynadié, J.B. Nousbaum, G. Coureau, A. Monnereau, I. Baldi, K. Hammas, B. Tretarre, M. Colonna, S. Plouvier, T. D’Almeida, F. Molinié, A. Cowppli-Bony, S. Bara, G. Defossez, B. LapÔtre-Ledoux, P. Grosclaude, L. Daubisse-Marliac, S. Luttmann, R. Stabenow, A. Nennecke, J. Kieschke, S. Zeissig, B. Holleczek, A. Katalinic, H. Birgisson, D. Murray, P.M. Walsh, G. Mazzoleni, F. Vittadello, F. Cuccaro, R. Galasso, G. Sampietro, S. Rosso, C. Gasparotti, G. Maifredi, M. Ferrante, R. Ragusa, M.L. Gambino, M. Lanzoni, P. Ballotari, E. Giacomazzi, S. Ferretti, A. Caldarella, G. Manneschi, G. Gatta, M. Sant, P. Baili, F. Berrino, L. Botta, A. Trama, R. Lillini, A. Bernasconi, L. Bonfarnuzzo, C. Vener, F. Didoné, P. Lasalvia, G. Del Monego, L. Buratti, G. Tagliabue, D. Serraino, L. Dal Maso, R. Capocaccia, R. De Angelis, E. Demuru, C. Di Benedetto, S. Rossi, M. Santaquilani, S. Venanzi, M. Tallon, L. Boni, S. Iacovacci, V. Gennaro, A.G. Russo, F. Gervasi, G. Spagnoli, L. Cavalieri d’’Oro, M. Fusco, M.F. Vitale, M. Usala, W. Mazzucco, M. Michiara, G. Chiranda, G. Cascone, C.P. Rollo, L. Mangone, F. Falcini, R. Cavallo, D. Piras, A. Madeddu, F. Bella, A.C. Fanetti, S. Minerba, G. Candela, T. Scuderi, R.V. Rizzello, M. Rugge, A. Brustolin, S. Pildava, G. Smailyte, M. Azzopardi, T.B. Johannesen, J. Didkowska, U. Wojciechowska, M. Bielska-Lasota, A. Pais, J. Rodrigues, M.J. Bento, A. Miranda, V. Zadnik, T. Zagar, C. Sánchez-Contador Escudero, P. Franch Sureda, A. Lopez de Munain, M. De-La-Cruz, M.D. Rojas, A. Aleman, A. Vizcaino, R. Marcos-Gragera, A. Sanvisens, M.J. Sanchez, M.D. Chirlaque, A. Sanchez-Gil, M. Guevara, E. Ardanaz, A. Ameijide, C. Carulla, Y. Bergeron, C. Bouchardy, S. Mohsen Mousavi, P. Went, M. Blum, A. Bordoni, O. Visser, S. Stevens, J. Broggio, A. Gavin, D. Morrison, and D.W. Huws

Subjects
cancer prevalence, cancer registries, cancer survivors, cancer survivorship, EUROCARE, Europe, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from US-SEER cancer registries. Relying on the EUROCARE-6 study dataset we compare standard vs alternative complete prevalence estimates using data from 62 registries in 27 countries by sex, cancer type and registration time.ResultsFor tumours mostly diagnosed in the elderly the empirical estimates differ little from standard estimates (on average less than 5% after 10-15 years of registration), especially for low prognosis cancers. For early-onset cancers (bone, brain, cervix uteri, testis, Hodgkin disease, soft tissues) the empirical method may produce substantial underestimations of complete prevalence (up to 20%) even when based on 35-year observations. SEER estimates are comparable to the standard ones for most cancers, including many early-onset tumours, even when derived from short time series (10-15 years). Longer observations are however needed when cancer-specific incidence and prognosis differ remarkably between US and European populations (endometrium, thyroid or stomach).DiscussionThese results may facilitate the dissemination of complete prevalence estimates across Europe and help bridge the current information gaps.

Published
2023
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18. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study

Author

Cardoso, Rafael, Guo, Feng, Heisser, Thomas, Hackl, Monika, Ihle, Petra, De Schutter, Harlinde, Van Damme, Nancy, Valerianova, Zdravka, Atanasov, Trajan, Májek, Ondřej, Mužík, Jan, Nilbert, Mef Christina, Tybjerg, Anne Julie, Innos, Kaire, Mägi, Margit, Malila, Nea, Bouvier, Anne-Marie, Bouvier, Véronique, Launoy, Guy, Woronoff, Anne-Sophie, Cariou, Mélanie, Robaszkiewicz, Michel, Delafosse, Patricia, Poncet, Florence, Katalinic, Alexander, Walsh, Paul M, Senore, Carlo, Rosso, Stefano, Vincerževskienė, Ieva, Lemmens, Valery E P P, Elferink, Marloes A G, Johannesen, Tom Børge, Kørner, Hartwig, Pfeffer, Frank, Bento, Maria José, Rodrigues, Jessica, Alves da Costa, Filipa, Miranda, Ana, Zadnik, Vesna, Žagar, Tina, Lopez de Munain Marques, Arantza, Marcos-Gragera, Rafael, Puigdemont, Montse, Galceran, Jaume, Carulla, Marià, Chirlaque, María-Dolores, Ballesta, Monica, Sundquist, Kristina, Sundquist, Jan, Weber, Marco, Jordan, Andrea, Herrmann, Christian, Mousavi, Mohsen, Ryzhov, Anton, Hoffmeister, Michael, and Brenner, Hermann

Published
2021
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20. Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study

Author

Van Eycken, L., Henau, K., Grozeva, T., Valerianova, Z., Innos, K., Mägi, M., Bouvier, V., Launoy, G., Robaszkiewicz, M., Bouvier, A.M., Jooste, V., Babaev, V., Katalinic, A., Ólafsdóttir, E.J., Tryggvadóttir, L., Amati, C., Baili, P., Bonfarnuzzo, S., Margutti, C., Meneghini, E., Minicozzi, P., Moretti, G., Sant, M., Cirilli, C., Carrozzi, G., Spata, E., Tumino, R., Rossi, P. Giorgi, Vicentini, M., Stracci, F., Bianconi, F., Contiero, P., Tagliabue, G., Kycler, W., Oko, M., Macek, P., Smok-Kalwat, J., Bielska-Lasota, M., Bento, M.J., Rodrigues, J, Mayer-da-Silva, A., Miranda, A., Primic-Žakelj, M., Jarm, K., Almar, E., Mateos, A., Bidaurrazaga, J., de la Cruz, M., Alberich, C., Torrella-Ramos, A., García, J.M. Díaz, Marcos-Navarro, AI, Carmona-Garcia, C., Marcos-Gragera, R., Luque-Fernandez, M.A., Sánchez-Pérez, M.J., Ardanaz, E., Guevara, M., Bouchardy, C., Fournier, E., Bouvier, Anne-Marie, Jooste, Valérie, Sanchez-Perez, Maria José, Bento, Maria José, Rocha Rodrigues, Jessica, Marcos-Gragera, Rafael, Carmona-Garcia, Maria Carmen, Luque-Fernandez, Miguel Angel, Minicozzi, Pamela, Bouvier, Véronique, Innos, Kaire, and Sant, Milena

Published
2021
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21. The effect of high‐flow arteriovenous fistulas on systemic haemodynamics and brain oxygenation

Author

Jan Malik, Anna Valerianova, Vladimir Tuka, Pavel Trachta, Vladimira Bednarova, Zdenka Hruskova, Marcela Slavikova, Mitchell H. Rosner, and Vladimir Tesar

Subjects
High‐output heart failure, Arteriovenous fistula, Effective cardiac output, Brain oximetry, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aims High‐flow arteriovenous fistula (AVF) for haemodialysis leads to profound haemodynamic changes and sometimes to heart failure (HF). Cardiac output (CO) is divided between the AVF and body tissues. The term effective CO (COef) represents the difference between CO and AVF flow volume (Qa) and better characterizes the altered haemodynamics that may result in organ hypoxia. We investigated the effects of Qa reduction on systemic haemodynamics and on brain oxygenation. Methods and results This is a single‐centre interventional study. Twenty‐six patients on chronic haemodialysis with high Qa (>1500 mL/min) were indicated for surgical Qa reduction for HF symptoms and/or signs of structural heart disease on echocardiography. The included patients underwent three sets of examinations: at 4 months and then 2 days prior and 6 weeks post‐surgical procedure. Clinical status, echocardiographical haemodynamic assessment, Qa, and brain oximetry were recorded. All parameters remained stable from selection to inclusion. After the procedure, Qa decreased from 3.0 ± 1.4 to 1.3 ± 0.5 L/min, P 2.0 L/min. These observations were mirrored by higher brain oxygenation and might explain HF symptoms and improved haemodynamics even in asymptomatic high Qa patients.

Published
2021
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22. Differences in survival and recurrence of colorectal cancer by stage across population‐based European registries.

Author

Bouvier, Anne‐Marie, Jooste, Valérie, Lillini, Roberto, Marcos‐Gragera, Rafael, Katalinic, Alexander, Giorgi Rossi, Paolo, Launoy, Guy, Bouvier, Véronique, Guevara, Marcela, Ardanaz, Eva, Rapiti Aylward, Elisabetta, Innos, Kaire, Barranco, Miguel Rodríguez, Sant, Milena, Van Eycken, L, Henau, K, Grozeva, T, Valerianova, Z, Innos, K, and Mägi, M

Subjects
COLORECTAL cancer, TUMOR classification, ONCOLOGIC surgery, OVERALL survival, CANCER patients, CANCER relapse
Abstract

Recurrence after colorectal cancer resection is rarely documented in the general population while a key clinical determinant for patient survival. We identified 8785 patients with colorectal cancer diagnosed between 2010 and 2013 and clinically followed up to 2020 in 15 cancer registries from seven European countries (Bulgaria, Switzerland, Germany, Estonia, France, Italy, and Spain). We estimated world age‐standardized net survival using a flexible cumulative excess hazard model. Recurrence rates were calculated for patients with initially resected stage I, II, or III cancer in six countries, using the actuarial survival method. The proportion of nonmetastatic resected colorectal cancers varied from 58.6% to 78.5% according to countries. The overall 5‐year net survival by country ranged between 60.8% and 74.5%. The absolute difference between the 5‐year survival extremes was 12.8 points for stage II (Bulgaria vs Switzerland), 19.7 points for stage III (Bulgaria vs. Switzerland) and 14.8 points for Stage IV and unresected cases (Bulgaria vs. Switzerland or France). Five‐year cumulative rate of recurrence among resected patients with stage I–III was 17.7%. As compared to the mean of the whole cohort, the risk of developing a recurrence did not differ between countries except a lower risk in Italy for both stage I/II and stage III cancers and a higher risk in Spain for stage III. Survival after colorectal cancer differed across the concerned European countries while there were slight differences in recurrence rates. Population‐based collection of cancer recurrence information is crucial to enhance efforts for evidence‐based management of colorectal cancer follow up. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials

Author

Claudia Vener, Silvia Rossi, Pamela Minicozzi, Rafael Marcos-Gragera, Hélène A. Poirel, Marc Maynadié, Xavier Troussard, Gabriella Pravettoni, Roberta De Angelis, Milena Sant, the EUROCARE-6 Working Group, M. Hackl, E. Van Eycken, Z. Valerianova, M. Sekerija, P. Pavlou, L. Dušek, H. Storm, M. Mägi, K. Innos, N. Malila, J. Pitkäniemi, M. Velten, X. Troussard, A.M. Bouvier, V. Jooste, A.V. Guizard, G. Launoy, S. Dabakuyo Yonli, M. Maynadié, A.S. Woronoff, J.B. Nousbaum, G. Coureau, A. Monnereau, I. Baldi, K. Hammas, B. Tretarre, M. Colonna, S. Plouvier, T. D’Almeida, F. Molinié, A. Cowppli-Bony, S. Bara, C. Schvartz, G. Defossez, B. Lapôtre-Ledoux, P. Grosclaude, S. Luttmann, R. Stabenow, A. Nennecke, J. Kieschke, S. Zeissig, B. Holleczek, A. Katalinic, H. Birgisson, D. Murray, P.M. Walsh, G. Mazzoleni, F. Vittadello, F. Cuccaro, R. Galasso, G. Sampietro, S. Rosso, M. Magoni, M. Ferrante, A. Sutera Sardo, M.L. Gambino, P. Ballotari, E. Giacomazzi, S. Ferretti, A. Caldarella, G. Manneschi, G. Gatta, M. Sant, P. Baili, F. Berrino, L. Botta, A. Trama, R. Lillini, A. Bernasconi, S. Bonfarnuzzo, C. Vener, F. Didonè, P. Lasalvia, G. Del Monego, M.C. Magri, L. Buratti, D. Serraino, L. Dal Maso, R. Capocaccia, R. De Angelis, E. Demuru, C. Di Benedetto, S. Rossi, M. Santaquilani, S. Venanzi, R.A. Filiberti, S. Iacovacci, V. Gennaro, A.G. Russo, G. Spagnoli, L. Cavalieri d’Oro, M. Fusco, M.F. Vitale, M. Usala, F. Vitale, M. Michiara, G. Chiranda, G. Cascone, E. Spata, L. Mangone, F. Falcini, R. Cavallo, D. Piras, A. Madeddu, F. Bella, A.C. Fanetti, S. Minerba, G. Candela, T. Scuderi, R.V. Rizzello, F. Stracci, G. Tagliabue, M. Rugge, A. Brustolin, S. Pildava, G. Smailyte, M. Azzopardi, T.B. Johannesen, J. Didkowska, U. Wojciechowska, M. Bielska-Lasota, A. Pais, J.L. Pontes, A. Miranda, C. Safaei Diba, V. Zadnik, T. Zagar, C. Sánchez-Contador Escudero, P. Franch Sureda, A. Lopez de Munain, M. De-La-Cruz, M.D. Rojas, A. Aleman, A. Vizcaino, R. Marcos-Gragera, M.J. Sanchez, M.D. Chirlaque, M. Guevara Eslava, E. Ardanaz, J. Galceran, M. Carulla, Y. Bergeron, C. Bouchardy, S. Mohsen Mousavi, A. Bordoni, O. Visser, J. Rashbass, A. Gavin, D. Morrison, and D. W. Huws

Subjects
cancer registries, chronic myeloid leukemia (CML), randomized controlled trials (RCTs), real-world data, survival, Europe, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15–64 years) diagnosed in 2000–2006 vs. 2007–2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.

Published
2022
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27. Thyroid Cancer Incidence in Bulgaria before and after the Introduction of Universal Salt Iodization: An Analysis of the National Cancer Registry Data

Author

Ludmila Borislavova Ivanova, Mircho Ivanov Vukov, and Zdravka Gardeva Vassileva-Valerianova

Subjects
bulgaria, cancer, epidemiology, incidence, thyroid, Medicine
Abstract

Background: Thyroid cancer is the most common malignancy of the endocrine system and it has become the fastest growing cancer among women. The suspected risk factors include increased exposure to ionizing radiation during childhood, environmental pollutants, possible iodine deficiency, and excessive iodine exposure. Aims: To analyze the thyroid cancer incidence between 1980 and 2013 in Bulgaria and to determine the incidence rate before and after the introduction of universal salt iodization in 1994 in regions with different iodine deficiency levels. Study Design: Retrospective cohort. Methods: The study was a retrospective analysis of the total number of thyroid cancer cases with all histological types in Bulgaria (thyroid cancer, ICD10 code C73), diagnosed between 01/01/1980 and 31/12/2013, and retrieved from the anonymous cancer registry database of the Bulgarian National Cancer Registry. Age-standardized rates of thyroid cancer per 100,000 persons were calculated for each year of the periods mentioned below by sex and age, utilizing the WHO world reference populations with a special statistical module of the Bulgarian National Cancer Registry’s software CancerRegBG, 2011. Incidence rates were reported by age, sex, and period of diagnosis (1980-86, 1987-93, 1994-99, 2000-2006, 2007-2013). Trends among males and females were analyzed separately, as well as by age category: 0-19, 20-44, 45-64, and 65+. Annual percentage changes of age-standardized incidence rates were analyzed by Joinpoint regression to determine trends using the Joinpoint statistical software SEER* Stat Software, Version 4.1.1, 2014. Results: The age-standardized rates of thyroid cancer in Bulgaria has been increasing since 1990, being higher among women compared to men (4.68 vs 2.81). The highest age-standardized rates of thyroid cancer was observed in women in the 2007-2013 period. The only significant joinpoint was recorded in 1990 for females and in 1991 for males. The highest incidence rates was in the Smolyan district, a region with historically existing iodine deficiency and relatively high post-Chernobyl radiation exposure. Conclusion: Our results showed that, in different regions, the age-standardized thyroid cancer rates between endemic and non-endemic differ greatly depending on the radiation dose from the Chernobyl accident. The role of iodine intake in thyroid cancer remains uncertain, but iodine deficiency could be a contributing factor to the increased risk of thyroid cancer.

Published
2020
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28. New Porcine Model of Arteriovenous Fistula Documents Increased Coronary Blood Flow at the Cost of Brain Perfusion

Author

Anna Valerianova, Mikulas Mlcek, Tomas Grus, Jan Malik, and Otomar Kittnar

Subjects
arteriovenous fistula, hyperkinetic circulation, tissue perfusion, animal model, cerebral oxygenation, coronary artery flow, Physiology, QP1-981
Abstract

Background: Arteriovenous fistulas (AVF) represent a low resistant circuit. It is known that their opening leads to decreased systemic vascular resistance, increased cardiac output and other hemodynamic changes. Possible competition of AVF and perfusion of other organs has been observed before, however the specific impact of AVF has not been elucidated yet. Previous animal models studied long-term changes associated with a surgically created high flow AVF. The aim of this study was to create a simple AVF model for the analysis of acute hemodynamic changes.Methods: Domestic female pigs weighing 62.6 ± 5.2 kg were used. All the experiments were held under general anesthesia. The AVF was created using high-diameter ECMO cannulas inserted into femoral artery and vein. Continuous hemodynamic monitoring was performed throughout the protocol. Near-infrared spectroscopy sensors, flow probes and flow wires were inserted to study brain and heart perfusion.Results: AVF blood flow was 2.1 ± 0.5 L/min, which represented around 23% of cardiac output. We observed increase in cardiac output (from 7.02 ± 2.35 L/min to 9.19 ± 2.99 L/min, p = 0.0001) driven dominantly by increased heart rate, increased pulmonary artery pressure, and associated right ventricular work. Coronary artery flow velocity rose. On the contrary, carotid artery flow and brain and muscle tissue oxygenation measured by NIRS decreased significantly.Conclusions: Our new non-surgical AVF model is reproducible and demonstrated an acute decrease of brain and muscle perfusion.

Published
2022
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30. Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): a population-based study

Author

De Angelis, Roberta, primary, Demuru, Elena, additional, Baili, Paolo, additional, Troussard, Xavier, additional, Katalinic, Alexander, additional, Chirlaque Lopez, Maria Dolores, additional, Innos, Kaire, additional, Santaquilani, Mariano, additional, Blum, Marcel, additional, Ventura, Leonardo, additional, Paapsi, Keiu, additional, Galasso, Rocco, additional, Guevara, Marcela, additional, Randi, Giorgia, additional, Bettio, Manola, additional, Botta, Laura, additional, Guzzinati, Stefano, additional, Dal Maso, Luigino, additional, Rossi, Silvia, additional, Hackl, Monika, additional, Van Eycken, Elizabeth, additional, Van Damme, Nancy, additional, Valerianova, Zdravka, additional, Sekerija, Mario, additional, Scoutellas, Vasos, additional, Demetriou, Anna, additional, Dušek, Ladislav, additional, Krejici, Denisa, additional, Storm, Hans, additional, Mägi, Margit, additional, Pitkäniemi, Janne, additional, Velten, Michel, additional, Bouvier, Anne-Marie, additional, Jooste, Valerie, additional, Guizard, Anne-Valérie, additional, Launoy, Guy, additional, Dabakuyo Yonli, Sandrine, additional, Maynadié, Marc, additional, Woronoff, Anne-Sophie, additional, Nousbaum, Jean-Baptiste, additional, Coureau, Gaëlle, additional, Monnereau, Alain, additional, Baldi, Isabelle, additional, Hammas, Karima, additional, Tretarre, Brigitte, additional, Colonna, Marc, additional, Plouvier, Sandrine, additional, D'Almeida, Tania, additional, Molinié, Florence, additional, Cowppli-Bony, Anne, additional, Bara, Simona, additional, Debreuve, Adeline, additional, Defossez, Gautier, additional, Lapôtre-Ledoux, Bénédicte, additional, Grosclaude, Pascale, additional, Daubisse-Marliac, Laetitia, additional, Luttmann, Sabine, additional, Stabenow, Roland, additional, Nennecke, Alice, additional, Kieschke, Joachim, additional, Zeissig, Sylke, additional, Holleczek, Bernd, additional, Birgisson, Helgi, additional, Murray, Deirdre, additional, Walsh, Paul M., additional, Mazzoleni, Guido, additional, Vittadello, Fabio, additional, Cuccaro, Francesco, additional, Sampietro, Giuseppe, additional, Rosso, Stefano, additional, Gasparotti, Cinzia, additional, Maifredi, Giovanni, additional, Ferrante, Margherita, additional, Ragusa, Rosalia, additional, Sutera Sardo, Antonella, additional, Gambino, Maria Letizia, additional, Lanzoni, Monica, additional, Ballotari, Paola, additional, Giacomazzi, Erica, additional, Ferretti, Stefano, additional, Caldarella, Adele, additional, Manneschi, Gianfranco, additional, Gatta, Gemma, additional, Sant, Milena, additional, Berrino, Franco, additional, Trama, Annalisa, additional, Lillini, Roberto, additional, Bernasconi, Alice, additional, Bonfarnuzzo, Simone, additional, Vener, Claudia, additional, Didonè, Fabio, additional, Lasalvia, Paolo, additional, Buratti, Lucia, additional, Tagliabue, Giovanna, additional, Serraino, Diego, additional, Capocaccia, Riccardo, additional, De Angelis, Roberta, additional, Di Benedetto, Corrado, additional, Venanzi, Serenella, additional, Tallon, Marco, additional, Boni, Luca, additional, Iacovacci, Silvia, additional, Gennaro, Valerio, additional, Russo, Antonio Giampiero, additional, Gervasi, Federico, additional, Spagnoli, Gianbattista, additional, Cavalieri d'Oro, Luca, additional, Fusco, Mario, additional, Vitale, Maria Francesca, additional, Usala, Mario, additional, Mazzucco, Walter, additional, Michiara, Maria, additional, Chiranda, Giorgio, additional, Cascone, Giuseppe, additional, Giurdanella, Maria Concetta, additional, Mangone, Lucia, additional, Falcini, Fabio, additional, Cavallo, Rossella, additional, Piras, Daniela, additional, Madeddu, Anselmo, additional, Bella, Francesca, additional, Fanetti, Anna Clara, additional, Minerba, Sante, additional, Candela, Giuseppina, additional, Scuderi, Tiziana, additional, Rizzello, Roberto Vito, additional, Stracci, Fabrizio, additional, Rugge, Massimo, additional, Brustolin, Angelita, additional, Pildava, Santa, additional, Smailyte, Giedre, additional, Azzopardi, Miriam, additional, Johannesen, Tom Børge, additional, Didkowska, Joanna, additional, Wojciechowska, Urszula, additional, Bielska-Lasota, Magdalena, additional, Pais, Ana, additional, Bento, Maria José, additional, Calisto, Rita, additional, Lourenço, António, additional, Safaei Diba, Chakameh, additional, Zadnik, Vesna, additional, Zagar, Tina, additional, Sánchez-Contador Escudero, Carmen, additional, Franch Sureda, Paula, additional, Lopez de Munain, Arantza, additional, De-La-Cruz, Marta, additional, Rojas, Marìa Dolores, additional, Aleman, Araceli, additional, Vizcaino, Ana, additional, Marcos-Gragera, Rafael, additional, Sanvisens, Arantza, additional, Sanchez, Maria Josè, additional, Sanchez-Gil, Antonia, additional, Ardanaz, Eva, additional, Galceran, Jaume, additional, Carulla, Maria, additional, Bergeron, Yvan, additional, Bouchardy, Christine, additional, Mohsen Mousavi, Seyed, additional, Went, Philip, additional, Bordoni, Andrea, additional, Visser, Otto, additional, Stevens, Sarah, additional, Broggio, John, additional, Bennett, Damien, additional, Gavin, Anna, additional, Morrison, David, additional, and Huws, Dyfed Wyn, additional

Published
2024
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33. Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study

Author

Hackl, Monika, Zborovskaya, Anna, Dimitrova, Nadya, Valerianova, Zdravka, Dušek, Ladislav, Mägi, Margit, Monnereau, Alain, Clavel, Jacqueline, Velten, Michel, Guizard, Anne-Valérie, Bouvier, Véronique, Troussard, Xavier, Woronoff, Anne-Sophie, Marrer, Emilie, Trétarre, Brigitte, Colonna, Marc, Ganry, Olivier, Grosclaude, Pascale, Holleczek, Berndt, Jakab, Zsuzsanna, Tryggvadóttir, Laufey, Mangone, Lucia, Merletti, Franco, Ferretti, Stefano, Caruso, Bianca, Michiara, Maria, Tumino, Rosario, Falcini, Fabio, Zanetti, Roberto, Tagliabue, Giovanna, Visser, Otto, Ursin, Giske, Mężyk, Ryszard, Kepska, Kamila, Laranja Pontes, José, Primic Žakelj, Maja, Fernández-Delgado, Rafael, Vicente Raneda, Marisa L, Almar Marqués, Enrique, Quirós Garcia, José Ramón, Lopez de Munain, Arantza, Marcos-Gragera, Rafael, Sanchez-Perez, Maria-Jose, Ramos Monserrat, Maria, Ardanaz, Eva, Galceran, Jaume, Khan, Staffan, Kuehni, Claudia E, Bouchardy, Christine, Levi, Fabio, Konzelmann, Isabelle, Rohrmann, Sabine, Vernon, Sally, Brewster, David H, White, Ceri, Dolya, Anastasia, Steliarova-Foucher, Eva, Fidler, Miranda M, Colombet, Murielle, Lacour, Brigitte, Kaatsch, Peter, Piñeros, Marion, Soerjomataram, Isabelle, Bray, Freddie, Coebergh, Jan Willem, Peris-Bonet, Rafael, and Stiller, Charles A

Published
2018
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34. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Bouzbid, S, Hamdi-Chérif, M, Zaidi, Z, Meguenni, K, Regagba, D, Bayo, S, Cheick Bougadari, T, Manraj, S S, Bendahhou, K, Fabowale, A, Bradshaw, D, Somdyala, N I M, Kumcher, I, Moreno, F, Calabrano, G H, Espinola, S B, Carballo Quintero, B, Fita, R, Diumenjo, M C, Laspada, W D, Ibañez, S G, Lima, C A, De Souza, P C F, Del Pino, K, Laporte, C, Curado, M P, de Oliveira, J C, Veneziano, C L A, Veneziano, D B, Latorre, M R D O, Tanaka, L F, Rebelo, M S, Santos, M O, Galaz, J C, Aparicio Aravena, M, Sanhueza Monsalve, J, Herrmann, D A, Vargas, S, Herrera, V M, Uribe, C J, Bravo, L E, Garcia, L S, Arias-Ortiz, N E, Morantes, D, Jurado, D M, Yépez Chamorro, M C, Delgado, S, Ramirez, M, Galán Alvarez, Y H, Torres, P, Martínez-Reyes, F, Jaramillo, L, Quinto, R, Castillo, J, Mendoza, M, Cueva, P, Yépez, J G, Bhakkan, B, Deloumeaux, J, Joachim, C, Macni, J, Carrillo, R, Shalkow Klincovstein, J, Rivera Gomez, R, Poquioma, E, Tortolero-Luna, G, Zavala, D, Alonso, R, Barrios, E, Eckstrand, A, Nikiforuk, C, Noonan, G, Turner, D, Kumar, E, Zhang, B, McCrate, F R, Ryan, S, MacIntyre, M, Saint-Jacques, N, Nishri, D E, McClure, C A, Vriends, K A, Kozie, S, Stuart-Panko, H, Freeman, T, George, J T, Brockhouse, J T, O'Brien, D K, Holt, A, Almon, L, Kwong, S, Morris, C, Rycroft, R, Mueller, L, Phillips, C E, Brown, H, Cromartie, B, Schwartz, A G, Vigneau, F, Levin, G M, Wohler, B, Bayakly, R, Ward, K C, Gomez, S L, McKinley, M, Cress, R, Green, M D, Miyagi, K, Ruppert, L P, Lynch, C F, Huang, B, Tucker, T C, Deapen, D, Liu, L, Hsieh, M C, Wu, X C, Schwenn, M, Gershman, S T, Knowlton, R C, Alverson, G, Copeland, G E, Bushhouse, S, Rogers, D B, Jackson-Thompson, J, Lemons, D, Zimmerman, H J, Hood, M, Roberts-Johnson, J, Rees, J R, Riddle, B, Pawlish, K S, Stroup, A, Key, C, Wiggins, C, Kahn, A R, Schymura, M J, Radhakrishnan, S, Rao, C, Giljahn, L K, Slocumb, R M, Espinoza, R E, Khan, F, Aird, K G, Beran, T, Rubertone, J J, Slack, S J, Garcia, L, Rousseau, D L, Janes, T A, Schwartz, S M, Bolick, S W, Hurley, D M, Whiteside, M A, Miller-Gianturco, P, Williams, M A, Herget, K, Sweeney, C, Johnson, A T, Keitheri Cheteri, M B, Migliore Santiago, P, Blankenship, S E, Farley, S, Borchers, R, Malicki, R, Espinoza, J R, Grandpre, J, Wilson, R, Edwards, B K, Mariotto, A, Lei, Y, Wang, N, Chen, J S, Zhou, Y, He, Y T, Song, G H, Gu, X P, Mei, D, Mu, H J, Ge, H M, Wu, T H, Li, Y Y, Zhao, D L, Jin, F, Zhang, J H, Zhu, F D, Junhua, Q, Yang, Y L, Jiang, C X, Biao, W, Wang, J, Li, Q L, Yi, H, Zhou, X, Dong, J, Li, W, Fu, F X, Liu, S Z, Chen, J G, Zhu, J, Li, Y H, Lu, Y Q, Fan, M, Huang, S Q, Guo, G P, Zhaolai, H, Wei, K, Zeng, H, Demetriou, A V, Mang, W K, Ngan, K C, Kataki, A C, Krishnatreya, M, Jayalekshmi, P A, Sebastian, P, Nandakumar, A, Malekzadeh, R, Roshandel, G, Keinan-Boker, L, Silverman, B G, Ito, H, Nakagawa, H, Sato, M, Tobori, F, Nakata, I, Teramoto, N, Hattori, M, Kaizaki, Y, Moki, F, Sugiyama, H, Utada, M, Nishimura, M, Yoshida, K, Kurosawa, K, Nemoto, Y, Narimatsu, H, Sakaguchi, M, Kanemura, S, Naito, M, Narisawa, R, Miyashiro, I, Nakata, K, Sato, S, Yoshii, M, Oki, I, Fukushima, N, Shibata, A, Iwasa, K, Ono, C, Nimri, O, Jung, K W, Won, Y J, Alawadhi, E, Elbasmi, A, Ab Manan, A, Adam, F, Sanjaajmats, E, Tudev, U, Ochir, C, Al Khater, A M, El Mistiri, M M, Teo, Y Y, Chiang, C J, Lee, W C, Buasom, R, Sangrajrang, S, Kamsa-ard, S, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Leklob, A, Sangkitipaiboon, S, Geater, S L, Sriplung, H, Ceylan, O, Kög, I, Dirican, O, Köse, T, Gurbuz, T, Karaşahin, F E, Turhan, D, Aktaş, U, Halat, Y, Yakut, C I, Altinisik, M, Cavusoglu, Y, Türkköylü, A, Üçüncü, N, Hackl, M, Zborovskaya, A A, Aleinikova, O V, Henau, K, Van Eycken, L, Valerianova, Z, Yordanova, M R, Šekerija, M, Dušek, L, Zvolský, M, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, A M, Guizard, A V, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Woronoff, A S, Daoulas, M, Robaszkiewicz, M, Clavel, J, Goujon, S, Lacour, B, Baldi, I, Pouchieu, C, Amadeo, B, Coureau, G, Orazio, S, Preux, P M, Rharbaoui, F, Marrer, E, Trétarre, B, Colonna, M, Delafosse, P, Ligier, K, Plouvier, S, Cowppli-Bony, A, Molinié, F, Bara, S, Ganry, O, Lapôtre-Ledoux, B, Grosclaude, P, Bossard, N, Uhry, Z, Bray, F, Piñeros, M, Stabenow, R, Wilsdorf-Köhler, H, Eberle, A, Luttmann, S, Löhden, I, Nennecke, A L, Kieschke, J, Sirri, E, Emrich, K, Zeissig, S R, Holleczek, B, Eisemann, N, Katalinic, A, Asquez, R A, Kumar, V, Petridou, E, Ólafsdóttir, E J, Tryggvadóttir, L, Clough-Gorr, K, Walsh, P M, Sundseth, H, Mazzoleni, G, Vittadello, F, Coviello, E, Cuccaro, F, Galasso, R, Sampietro, G, Giacomin, A, Magoni, M, Ardizzone, A, D'Argenzio, A, Castaing, M, Grosso, G, Lavecchia, A M, Sutera Sardo, A, Gola, G, Gatti, L, Ricci, P, Ferretti, S, Serraino, D, Zucchetto, A, Celesia, M V, Filiberti, R A, Pannozzo, F, Melcarne, A, Quarta, F, Russo, A G, Carrozzi, G, Cirilli, C, Cavalieri d'Oro, L, Rognoni, M, Fusco, M, Vitale, M F, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Boschetti, L, Borciani, E, Seghini, P, Maule, M M, Merletti, F, Tumino, R, Mancuso, P, Vicentini, M, Cassetti, T, Sassatelli, R, Falcini, F, Giorgetti, S, Caiazzo, A L, Cavallo, R, Cesaraccio, R, Pirino, D R, Contrino, M L, Tisano, F, Fanetti, A C, Maspero, S, Carone, S, Mincuzzi, A, Candela, G, Scuderi, T, Gentilini, M A, Piffer, S, Rosso, S, Barchielli, A, Caldarella, A, Bianconi, F, Stracci, F, Contiero, P, Tagliabue, G, Rugge, M, Zorzi, M, Beggiato, S, Brustolin, A, Berrino, F, Gatta, G, Sant, M, Buzzoni, C, Mangone, L, Capocaccia, R, De Angelis, R, Zanetti, R, Maurina, A, Pildava, S, Lipunova, N, Vincerževskiené, I, Agius, D, Calleja, N, Siesling, S, Larønningen, S, Møller, B, Dyzmann-Sroka, A, Trojanowski, M, Góźdź, S, Mężyk, R, Mierzwa, T, Molong, L, Rachtan, J, Szewczyk, S, Błaszczyk, J, Kępska, K, Kościańska, B, Tarocińska, K, Zwierko, M, Drosik, K, Maksimowicz, K M, Purwin-Porowska, E, Reca, E, Wójcik-Tomaszewska, J, Tukiendorf, A, Grądalska-Lampart, M, Radziszewska, A U, Gos, A, Talerczyk, M, Wyborska, M, Didkowska, J A, Wojciechowska, U, Bielska-Lasota, M, Forjaz de Lacerda, G, Rego, R A, Bastos, J, Silva, M A, Antunes, L, Laranja Pontes, J, Mayer-da-Silva, A, Miranda, A, Blaga, L M, Coza, D, Gusenkova, L, Lazarevich, O, Prudnikova, O, Vjushkov, D M, Egorova, A G, Orlov, A E, Kudyakov, L A, Pikalova, L V, Adamcik, J, Safaei Diba, C, Primic-Žakelj, M, Zadnik, V, Larrañaga, N, Lopez de Munain, A, Herrera, A A, Redondas, R, Marcos-Gragera, R, Vilardell Gil, M L, Molina, E, Sánchez Perez, M J, Franch Sureda, P, Ramos Montserrat, M, Chirlaque, M D, Navarro, C, Ardanaz, E E, Guevara, M M, Fernández-Delgado, R, Peris-Bonet, R, Carulla, M, Galceran, J, Alberich, C, Vicente-Raneda, M, Khan, S, Pettersson, D, Dickman, P, Avelina, I, Staehelin, K, Camey, B, Bouchardy, C, Schaffar, R, Frick, H, Herrmann, C, Bulliard, J L, Maspoli-Conconi, M, Kuehni, C E, Redmond, S M, Bordoni, A, Ortelli, L, Chiolero, A, Konzelmann, I, Matthes, K L, Rohrmann, S, Broggio, J, Rashbass, J, Fitzpatrick, D, Gavin, A, Clark, D I, Deas, A J, Huws, D W, White, C, Montel, L, Rachet, B, Turculet, A D, Stephens, R, Chalker, E, Phung, H, Walton, R, You, H, Guthridge, S, Johnson, F, Gordon, P, D'Onise, K, Priest, K, Stokes, B C, Venn, A, Farrugia, H, Thursfield, V, Dowling, J, Currow, D, Hendrix, J, Lewis, C, Allemani, Claudia, Matsuda, Tomohiro, Di Carlo, Veronica, Harewood, Rhea, Matz, Melissa, Nikšić, Maja, Bonaventure, Audrey, Valkov, Mikhail, Johnson, Christopher J, Estève, Jacques, Ogunbiyi, Olufemi J, Azevedo e Silva, Gulnar, Chen, Wan-Qing, Eser, Sultan, Engholm, Gerda, Stiller, Charles A, Monnereau, Alain, Woods, Ryan R, Visser, Otto, Lim, Gek Hsiang, Aitken, Joanne, Weir, Hannah K, and Coleman, Michel P

Published
2018
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35. Arteriovenous Hemodialysis Access Stenosis Diagnosed by Duplex Doppler Ultrasonography: A Review

Author

Jan Malik, Cora de Bont, Anna Valerianova, Zdislava Krupickova, and Ludmila Novakova

Subjects
arteriovenous fistula, arteriovenous graft, hemodialysis, vascular ultrasonography, Medicine (General), R5-920
Abstract

Arteriovenous fistula (AVF) is currently the hemodialysis access with the longest life expectations for the patients. However, even the AVF is at risk for many complications, especially the development of stenosis. The latter can not only lead to inadequate hemodialysis but also lead to AVF thrombosis. Duplex Doppler ultrasonography is a very precise method, in the hands of experienced professionals, for the diagnosis of AVF complications. In this review, we summarize the ultrasound diagnostic criteria of significant stenoses and their indication for procedural therapy.

Published
2022
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36. Novel PD-L1- and collagen-expressing patient-derived cell line of undifferentiated pleomorphic sarcoma (JBT19) as a model for cancer immunotherapy

Author

Taborska, Pavla, primary, Lukac, Pavol, additional, Stakheev, Dmitry, additional, Rajsiglova, Lenka, additional, Kalkusova, Katerina, additional, Strnadova, Karolina, additional, Lacina, Lukas, additional, Dvorankova, Barbora, additional, Novotny, Jiri, additional, Kolar, Michal, additional, Vrana, Milena, additional, Cechova, Hana, additional, Ransdorfova, Sarka, additional, Valerianova, Marie, additional, Smetana, Karel, additional, Vannucci, Luca, additional, and Smrz, Daniel, additional

Published
2023
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37. Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study

Author

Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Bouvier, A.M., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Clough-Gorr, K., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Maso, L. Dal, De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Knijn, A., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Natali, M., Filiberti, R.A., Marani, E., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Traina, A., Staiti, R., Vitale, F., Cusimano, R., Michiara, M., Tumino, R., Falcini, F., Caiazzo, A.L., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Almar, E., Mateos, A., Lopez de Munain, A., Larrañaga, N., Torrella-Ramos, A., Díaz García, J.M., Jimenez-Chillaron, R., Marcos-Gragera, R., Vilardell, L., Moreno-Iribas, C., Ardanaz, E., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Damhuis, R., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Fitzpatrick, D., Huws, D.W., White, C., Minicozzi, Pamela, Innos, Kaire, Sánchez, Maria-José, Trama, Annalisa, Walsh, Paul M., Marcos-Gragera, Rafael, Dimitrova, Nadya, Botta, Laura, Visser, Otto, Rossi, Silvia, Tavilla, Andrea, and Sant, Milena

Published
2017
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38. Geographical variability in survival of European children with central nervous system tumours

Author

Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Clavel, J., Lacour, B., Desandes, E., Brenner, H., Kaatsch, P., Katalinic, A., Garami, M., Jakab, Z., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Marani, E., Ricci, P., Pascucci, C., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Merletti, F., Maule, M., Tumino, R., Mangone, L., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Vicente Raneda, M., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Peris-Bonet, R., Pardo Romaguera, E., Galceran, J., Carulla, M., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Verne, J., Stiller, C., Gavin, A., Donnelly, C., Brewster, D.H., Sánchez, M.-J., and Rutkowski, S.

Published
2017
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39. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet—a population-based study

Author

Hackl, Monika, Henau, Kris, Van Damme, Nancy, Valerianova, Zdravka, Sekerija, Mario, Dušek, Ladislav, Mägi, Margit, Paapsi, Keiu, Malila, Nea, Velten, Michel, Troussard, Xavier, Bouvier, Veronique, Guizard, Anne-Valérie, Bouvier, Anne-Marie, Arveux, Patrick, Maynadié, Marc, Woronoff, Anne-Sophie, Robaszkiewicz, Michel, Baldi, Isabelle, Monnereau, Alain, Tretarre, Brigitte, Colonna, Marc, Molinié, Florence, Bara, Simona, Schvartz, Claire, Lapôtre-Ledoux, Bénédicte, Grosclaude, Pascale, Stabenow, Roland, Luttmann, Sabine, Nennecke, Alice, Engel, Jutta, SchubertFritschle, Gabriele, Heidrich, Jan, Holleczek, Bernd, Jónasson, Jón Gunnlaugur, Clough-Gorr, Kerri, Mazzoleni, Guido, Giacomin, Adriano, Sardo, Antonella Sutera, Barchielli, Alessandro, Serraino, Diego, Collarile, Paolo, Pannozzo, Fabio, Ricci, Paolo, Autelitano, Mariangela, Spagnoli, Gianbattista, Fusco, Mario, Usala, Mario, Vitale, Francesco, Michiara, Maria, Tumino, Rosario, Mangone, Lucia, Falcini, Fabio, Ferretti, Stefano, Filiberti, Rosa Angela, Marani, Enza, Caiazzo, Anna Luisa, Iannelli, Arturo, Sensi, Flavio, Piffer, Silvano, Gentilini, Maria, Madeddu, Anselmo, Colanino, Antonino Ziino, Maspero, Sergio, Candela, Pina, Stracci, Fabrizio, Tagliabue, Giovanna, Rugge, Massimo, Baili, Paolo, Minicozzi, Pamela, Sant, Milena, Tereanu, Carmen, Francisci, Silvia, Tavilla, Andrea, Pierannunzio, Daniela, Rossi, Silvia, Santaquilani, Mariano, Knijn, Arnold, Pildava, Santa, Smailyte, Giedre, Calleja, Neville, Agius, Dominic, Johannesen, Tom Børge, Rachtan, Jadwiga, Gózdz, Stanislaw, Blaszczyk, Jerzy, Kepska, Kamila, Lacerda, Gonçalo Forjaz de, Bento, Maria José, Miranda, Ana, Diba, Chakameh Safaei, Žagar, Tina, Almar, Enrique, Larrañaga, Nerea, Munain, Arantza Lopez de, Torrella-Ramos, Ana, García, José María Díaz, Marcos-Gragera, Rafael, Sanchez, Maria Josè, Navarro, Carmen, Salmeron, Diego, Moreno-Iribas, Conchi, Galceran, Jaume, Carulla, Marià, Mousavi, Mohsen, Bouchardy, Christine, Ess, Silvia M., Bordoni, Andrea, Konzelmann, Isabelle, Rashbass, Jem, Gavin, Anna, Brewster, David H, Huws, Dyfed Wyn, Ho, Vincent KY, Benhamou, Ellen, Gatta, Gemma, Capocaccia, Riccardo, Botta, Laura, Mallone, Sandra, De Angelis, Roberta, Ardanaz, Eva, Comber, Harry, Dimitrova, Nadya, Leinonen, Maarit K, Siesling, Sabine, van der Zwan, Jan M, Van Eycken, Liesbet, Visser, Otto, Žakelj, Maja P, Anderson, Lesley A, Bella, Francesca, Kaire, Innos, Otter, Renée, Stiller, Charles A, and Trama, Annalisa

Published
2017
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40. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Bouzbid, S, Hamdi-Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, GC, Manraj, SS, Reynders, D, Wabinga, HR, Chokunonga, E, Moreno, F, Lima, CA, Asturian Laporte, C, de Oliveira, JC, de Aquino, JA Pontes, Gallagher, SM Vargas, Uribe, CJ, Bravo, LE, Yepez Chamorro, MC, Torres Alvarado, G, Galán Alvarez, YH, Martinez Reyes, FC, Castillo Calvas, JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo-Gutiérrez, A, Zavala Zegarra, DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, MacIntyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart-Panko, H, Wilson, RJ, Kosary, C, Shen, X, Brockhouse, J, Yee, GA, Mitchell, TC, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, RK, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, GM, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, CF, Lai, SM, Tucker, TC, Wu, XC, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, DB, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, JA, Riddle, B, Stroup, A, Wiggins, C, Schymura, MJ, Giljahn, LK, Sheikh, A, Schubert, S, Aldinger, W, Fulton, JP, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, JR, Hernandez, BY, Abulfateh, N, Wang, N, Ngan, RKC, Lingegowda, KB, Swaminathan, R, Koyande, SS, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, YJ, Kim, CH, Hong, NS, Nam, HS, Kweon, S, Kim, WC, Huh, JS, Jung, KW, Yoo, CI, Elbasmy, A, Laudico, AV, Lumague, MR, AlMutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, AV, Bouvier, V, Troussard, X, Woronoff, AS, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, SR, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, PM, Mangone, L, Merletti, F, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, MA, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris-Bonet, R, Vicente Raneda, ML, Almar Marqués, E, Quirós Garcia, JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García, JM, Marcos-Gragera, R, Sanchez-Perez, MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, CE, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, CA, Gavin, AT, Brewster, DH, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, TJ, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova-Foucher, E, Steliarova-Foucher, Eva, Colombet, Murielle, Ries, Lynn A G, Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young, and Stiller, Charles A

Published
2017
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41. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Author

Bouzbid, S, Hamdi-Chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, SH, El Mistiri, MM, Bayo, S, Malle, B, Manraj, SS, Sewpaul-Sungkur, R, Fabowale, Ogunbiyi, OJ, Bradshaw, D, Somdyala, NIM, Stefan, DC, Abdel-Rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, MS, Laura, EA, Espinola, SB, Calabrano, GH, Carballo Quintero, B, Fita, R, Garcilazo, DA, Giacciani, PL, Diumenjo, MC, Laspada, WD, Green, MA, Lanza, MF, Ibañez, SG, Lima, CA, de Oliveira, E Lobo, Daniel, C, Scandiuzzi, C, De Souza, PCF, Melo, CD, Del Pino, K, Laporte, C, Curado, MP, de Oliveira, JC, Veneziano, CLA, Veneziano, DB, Azevedo e Silva, G, Galaz, JC, Moya, JA, Herrmann, DA, Vargas, S, Herrera, VM, Uribe, CJ, Bravo, LE, Arias-Ortiz, NE, Jurado, DM, Yépez, MC, Galán, YH, Torres, P, Martínez-Reyes, F, Pérez-Meza, ML, Jaramillo, L, Quinto, R, Cueva, P, Yépez, JG, Torres-Cintrón, CR, Tortolero-Luna, G, Alonso, R, Barrios, E, Nikiforuk, C, Shack, L, Coldman, AJ, Woods, RR, Noonan, G, Turner, D, Kumar, E, Zhang, B, McCrate, FR, Ryan, S, Hannah, H, Dewar, RAD, MacIntyre, M, Lalany, A, Ruta, M, Marrett, L, Nishri, DE, McClure, C, Vriends, KA, Bertrand, C, Louchini, R, Robb, KI, Stuart-Panko, H, Demers, S, Wright, S, George, JT, Shen, X, Brockhouse, JT, O'Brien, DK, Ward, KC, Almon, L, Bates, J, Rycroft, R, Mueller, L, Phillips, C, Brown, H, Cromartie, B, Schwartz, AG, Vigneau, F, MacKinnon, JA, Wohler, B, Bayakly, AR, Clarke, CA, Glaser, SL, West, D, Green, MD, Hernandez, BY, Johnson, CJ, Jozwik, D, Charlton, ME, Lynch, CF, Huang, B, Tucker, TC, Deapen, D, Liu, L, Hsieh, MC, Wu, XC, Stern, K, Gershman, ST, Knowlton, RC, Alverson, J, Copeland, GE, Rogers, DB, Lemons, D, Williamson, LL, Hood, M, Hosain, GM, Rees, JR, Pawlish, KS, Stroup, A, Key, C, Wiggins, C, Kahn, AR, Schymura, MJ, Leung, G, Rao, C, Giljahn, L, Warther, B, Pate, A, Patil, M, Schubert, SS, Rubertone, JJ, Slack, SJ, Fulton, JP, Rousseau, DL, Janes, TA, Schwartz, SM, Bolick, SW, Hurley, DM, Richards, J, Whiteside, MA, Nogueira, LM, Herget, K, Sweeney, C, Martin, J, Wang, S, Harrelson, DG, Cheteri, MB Keitheri, Farley, S, Hudson, AG, Borchers, R, Stephenson, L, Espinoza, JR, Weir, HK, Edwards, BK, Wang, N, Yang, L, Chen, JS, Song, GH, Gu, XP, Zhang, P, Ge, HM, Zhao, DL, Zhang, JH, Zhu, FD, Tang, JG, Shen, Y, Wang, J, Li, QL, Yang, XP, Dong, J, Li, W, Cheng, LP, Chen, JG, Huang, QH, Huang, SQ, Guo, GP, Wei, K, Chen, WQ, Zeng, H, Demetriou, AV, Pavlou, P, Mang, WK, Ngan, KC, Kataki, AC, Krishnatreya, M, Jayalekshmi, PA, Sebastian, P, Sapkota, SD, Verma, Y, Nandakumar, A, Suzanna, E, Keinan-Boker, L, Silverman, BG, Ito, H, Nakagawa, H, Hattori, M, Kaizaki, Y, Sugiyama, H, Utada, M, Katayama, K, Narimatsu, H, Kanemura, S, Koike, T, Miyashiro, I, Yoshii, M, Oki, I, Shibata, A, Matsuda, T, Nimri, O, Ab Manan, A, Pathy, N Bhoo, Chimedsuren, O, Tuvshingerel, S, Al Khater, AHM, Al-Eid, H, Jung, KW, Won, YJ, Chiang, CJ, Lai, MS, Suwanrungruang, K, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Geater, SL, Sriplung, H, Eser, S, Yakut, CI, Hackl, M, Mühlböck, H, Oberaigner, W, Zborovskaya, AA, Aleinikova, OV, Henau, K, Van Eycken, L, Dimitrova, N, Valerianova, Z, Šekerija, M, Zvolský, M, Engholm, G, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, AM, Faivre, J, Guizard, AV, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Fournier, E, Woronoff, AS, Daoulas, M, Clavel, J, Le Guyader-Peyrou, S, Monnereau, A, Trétarre, B, Colonna, M, Cowppli-Bony, A, Molinié, F, Bara, S, Degré, D, Ganry, O, Lapôtre-Ledoux, B, Grosclaude, P, Estève, J, Bray, F, Piñeros, M, Sassi, F, Stabenow, R, Eberle, A, Erb, C, Nennecke, A, Kieschke, J, Sirri, E, Kajueter, H, Emrich, K, Zeissig, SR, Holleczek, B, Eisemann, N, Katalinic, A, Brenner, H, Asquez, RA, Kumar, V, Ólafsdóttir, EJ, Tryggvadóttir, L, Comber, H, Walsh, PM, Sundseth, H, Devigili, E, Mazzoleni, G, Giacomin, A, Bella, F, Castaing, M, Sutera, A, Gola, G, Ferretti, S, Serraino, D, Zucchetto, A, Lillini, R, Vercelli, M, Busco, S, Pannozzo, F, Vitarelli, S, Ricci, P, Pascucci, C, Autelitano, M, Cirilli, C, Federico, M, Fusco, M, Vitale, MF, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Maule, MM, Sacerdote, C, Tumino, R, Di Felice, E, Vicentini, M, Falcini, F, Cremone, L, Budroni, M, Cesaraccio, R, Contrino, ML, Tisano, F, Fanetti, AC, Maspero, S, Candela, G, Scuderi, T, Gentilini, MA, Piffer, S, Rosso, S, Sacchetto, L, Caldarella, A, La Rosa, F, Stracci, F, Contiero, P, Tagliabue, G, Dei Tos, AP, Zorzi, M, Zanetti, R, Baili, P, Berrino, F, Gatta, G, Sant, M, Capocaccia, R, De Angelis, R, Liepina, E, Maurina, A, Smailyte, G, Agius, D, Calleja, N, Siesling, S, Visser, O, Larønningen, S, Møller, B, Dyzmann-Sroka, A, Trojanowski, M, Gózdz, S, Mezyk, R, Gradalska-Lampart, M, Radziszewska, AU, Didkowska, JA, Wojciechowska, U, Blaszczyk, J, Kepska, K, Bielska-Lasota, M, Kwiatkowska, K, Forjaz, G, Rego, RA, Bastos, J, Silva, MA, Antunes, L, Bento, MJ, Mayer-da-Silva, A, Miranda, A, Coza, D, Todescu, AI, Valkov, MY, Adamcik, J, Safaei Diba, C, Primic-Žakelj, M, Žagar, T, Stare, J, Almar, E, Mateos, A, Quirós, JR, Bidaurrazaga, J, Larrañaga, N, Díaz García, JM, Marcos, AI, Marcos-Gragera, R, Vilardell Gil, ML, Molina, E, Sánchez, MJ, Sureda, P Franch, Montserrat, M Ramos, Chirlaque, MD, Navarro, C, Ardanaz, EE, Moreno-Iribas, CC, Fernández-Delgado, R, Peris-Bonet, R, Galceran, J, Khan, S, Lambe, M, Camey, B, Bouchardy, C, Usel, M, Ess, SM, Herrmann, C, Bulliard, JL, Maspoli-Conconi, M, Frick, H, Kuehni, CE, Schindler, M, Bordoni, A, Spitale, A, Chiolero, A, Konzelmann, I, Dehler, SI, Matthes, KL, Rashbass, J, Stiller, CA, Fitzpatrick, D, Gavin, A, Bannon, F, Black, RJ, Brewster, DH, Huws, DW, White, C, Finan, P, Allemani, C, Bonaventure, A, Carreira, H, Coleman, MP, Di Carlo, V, Harewood, R, Liu, K, Matz, M, Montel, L, Nikšić, M, Rachet, B, Sanz, N, Spika, D, Stephens, R, Peake, M, Murphy, MFG, Chalker, E, Newman, L, Baker, D, Soeberg, MJ, Aitken, J, Scott, C, Stokes, BC, Venn, A, Farrugia, H, Giles, GG, Threlfall, T, Currow, D, You, H, Hendrix, J, Lewis, C, Latorre, MRDO, Tanaka, LF, Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos-Gragera, Rafael, Peris-Bonet, Rafael, Piñeros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F G, Coleman, Michel P, and Allemani, Claudia

Published
2017
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42. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5

Author

Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Guizard, A.V., Faivre, J., Woronoff, A.S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Vercelli, M., Ricci, P., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Mangone, L., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Ho, V., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Dal Maso, L., Pacini, F., van Dijk, B.A.C., Larrañaga, N., Rubió-Casadevall, J., Kowalska, A., and Virdone, S.

Published
2017
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43. Cardiorenal Syndromes and Their Role in Water and Sodium Homeostasis.

Author

BURYSKOVA SALAJOVA, Kristina, MALIK, Jan, and VALERIANOVA, Anna

Subjects
CARDIO-renal syndrome, HOMEOSTASIS, EXTRACELLULAR fluid, PATHOLOGICAL physiology, RENIN-angiotensin system
Abstract

Sodium is the main osmotically active ion in the extracellular fluid and its concentration goes hand in hand with fluid volume. Under physiological conditions, homeostasis of sodium and thus amount of fluid is regulated by neural and humoral interconnection of body tissues and organs. Both heart and kidneys are crucial in maintaining volume status. Proper kidney function is necessary to excrete regulated amount of water and solutes and adequate heart function is inevitable to sustain renal perfusion pressure, oxygen supply etc. As these organs are bidirectionally interconnected, injury of one leads to dysfunction of another. This condition is known as cardiorenal syndrome. It is divided into five subtypes regarding timeframe and pathophysiology of the onset. Hemodynamic effects include congestion, decreased cardiac output, but also production of natriuretic peptides. Renal congestion and hypoperfusion leads to kidney injury and maladaptive activation of renin-angiotensin-aldosterone system and sympathetic nervous system. In cardiorenal syndromes sodium and water excretion is impaired leading to volume overload and far-reaching negative consequences, including higher morbidity and mortality of these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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44. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Author

Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., Stefan, D.C., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Alexandre, T.S., Verdugo, A.S., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Keitheri Cheteri, M.B., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo Pathy, N., Chimedsuren, O., Tuvshingerel, S., Al Khater, A.H.M., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Sant, Milena, Chirlaque, Maria Dolores, Visser, Otto, Gore, Martin, and Allemani, Claudia

Published
2017
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45. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)

Author

Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Latorre, M.R.D.O., Tanaka, L.F., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, 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Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C.A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Carreira, Helena, Salmerón, Diego, Chirlaque, Maria Dolores, and Allemani, Claudia

Published
2017
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49. Heart failure with preserved ejection fraction is the most frequent but commonly overlooked phenotype in patients on chronic hemodialysis

Author

Malik, Jan, primary, Valerianova, Anna, additional, Pesickova, Satu Sinikka, additional, Michalickova, Kristyna, additional, Hladinova, Zuzana, additional, Hruskova, Zdenka, additional, Bednarova, Vladimira, additional, Rocinova, Katarina, additional, Tothova, Monika, additional, Kratochvilova, Marketa, additional, Kaiserova, Lucie, additional, Buryskova Salajova, Kristina, additional, Lejsek, Vaclav, additional, Sevcik, Martin, additional, and Tesar, Vladimir, additional

Published
2023
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