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1,154 results on '"Valero V"'

1. 3-D thermal and radiation-matter interaction simulations of a SiC solid-state detector for neutron flux measurements in JSI TRIGA Mark II research reactor

Author

Valero V., Ottaviani L., Lyoussi A., Ghninou H., Radulović V., Snoj L., Pungerčič A., Volte A., Carette M., and Reynard-Carette C.

Subjects
neutron detection, silicon carbide, irradiation campaign, thermal, radiation-matter interaction, 3-d simulations, Physics, QC1-999
Abstract

Neutron detection is a relevant topic in the field of nuclear instrumentation. It is at the heart of the concerns for fusion applications (neutron diagnostics, measurements inside the Test Blanket Modules TBM) as well as for fission applications (in-core and ex-core monitoring, neutron mapping or safety applications in research reactors). Moreover, due to the even more harsh conditions of the future experimental reactors such as the Jules Horowitz Reactor (JHR) or International Thermonuclear Experimental Reactor (ITER), neutron detectors need to be adapted to high neutron and γ fluxes, high nuclear heating rates and high temperatures. Consequently, radiation and temperature hardened sensors with fast response, high energy resolution and stability in a mixed neutron and γ environment are required. All these requirements make wide-bandgap semiconductors and, more precisely, Silicon Carbide (SiC) serious candidates due to their intrinsic characteristics in such extreme environments. Thus, since the last decades, SiC-based detectors are developed and studied for neutron detection in various nuclear facilities. In this paper, a SiC-based neutron detector is 3-D designed and studied through thermal and radiation-matter interaction numerical simulations for a future irradiation campaign at the Jožef Stefan Institute TRIGA Mark II research reactor in Slovenia. Firstly, this paper presents the scientific background and issues of our SiC-based detectors. In a second part the 3-D geometry is shown. Thereafter, the 3-D numerical thermal simulation results are reported. Finally, the 3-D numerical radiation/matter interaction simulations results are presented.

Published
2021
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2. Emerging role of Hpo signaling and YAP in hepatocellular carcinoma

Author

Valero V III, Pawlik TM, and Anders RA

Subjects
hepatocellular carcinoma, Yes-Associated-Protein, Hippo signaling, liver cancer, hepatic malignancy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Vicente Valero III,1 Timothy M Pawlik,1 Robert A Anders21Department of Surgery, Division of Surgical Oncology, 2Department of Pathology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related mortality worldwide. Due to the poor prognosis and limited therapeutic options, there is great interest in further understanding better the molecular underpinnings and potential molecular targets associated with HCC. The Hippo (Hpo) signaling pathway and YAP, its principal downstream effector, represent an innovative area of research in HCC. Pioneered in Drosophila melanogaster, the Hpo cascade controls tissue homeostasis including organ size, cell proliferation, apoptosis, as well as cell-cycle regulation and differentiation. This conserved kinase cascade in mammals depends on central control by the tumor suppressor mammalian sterile 20-like kinase 1/2 (Mst1/2). The Mst1/2 commences the downstream kinase cascade, ultimately activating the oncoprotein YAP and allowing its physical association with downstream targets to enhance the gene expression signatures that are involved in proliferation and survival. Alterations in YAP expression and defective regulation of other key Hpo pathway members, such as Mst1/2, Salvador, neurofibromatosis and Mer (Nf2/mer), large tumor suppressor homolog 1/2 (Lats1/2), and Mps one binder kinase activator-like 1A and 1B (Mob1) drive carcinogenesis in animal models. The dysregulation of the Hpo pathway – resulting in an unchecked activation of YAP – culminates in the development of a broad range of human tumor types, including HCC. The abrogation of Mst1/2-mediated YAP phosphorylation permits YAP entry into the nucleus in murine models and functions similarly in human HCCs. Chemoresistance mechanisms displayed by HCC tumors occur in a YAP-dependent manner. The HCC specimens exhibit YAP overexpression, and YAP serves as an independent prognostic marker for disease-free survival and overall survival in patients with HCC. Recently, the small molecule inhibitor, verteporfin has been shown to attenuate YAP activity in murine models, perhaps offering a novel therapeutic approach for patients with advanced HCC.Keywords: hepatocellular carcinoma, yes-associated-protein, Hippo signaling, liver cancer, hepatic malignancy

Published
2015

3. Halotolerant/alkalophilic bacteria associated with the cyanobacterium Arthrospira platensis (Nordstedt) Gomont that promote early growth in Sorghum bicolor (L.) Moench

Author

Gómez G. Liliana Cecilia, Valero V. Nelson, and de Brigard C. Rosa

Subjects
BPCV, fitohormonas, rizobacteria, microbiología agrícola, ácido 3-indol acético., Plant ecology, QK900-989
Abstract

Arthrospira platensis associated bacteria (APAB) identified through molecuar biology like Bacillus okhensis, Indibacter alkaliphilus and Halomonas sp., are also producing 3-indol acetic acid (IAA), these bacteria was used in early plant growth promotion tests over Sorghum bicolor, these bioassay was considered indirect evidence to suggest that APAB also may have stimulatory effects over A. platensis growth naturally. I. alkaliphilus and B. okhensis enhanced early germination of S. bicolor seads, with better results than that achieved by Azospirillum brasilense, bacterium used like reference as a common plant growth promoting rizobacteria. The three APAB enhanced significative differences (P≤0.05) over morphoagronomic parameters, I. alkaliphilus and B. okhensis exhibit better resoults in elongation stimulation and root and foliage dry weight. Above evidence suggest this bacteria like plant growth promoting and it recomended testing with A. platensis axenic cultures and its associated bactteri for understanding true interaction between them.

Published
2012

5. Predicted sensitivity to endocrine therapy for stage II-III hormone receptor-positive and HER2-negative (HR+/HER2−) breast cancer before chemo-endocrine therapy

Author

Du, L., Yau, C., Brown-Swigart, L., Gould, R., Krings, G., Hirst, G.L., Bedrosian, I., Layman, R.M., Carter, J.M., Klein, M., Venters, S., Shad, S., van der Noordaa, M., Chien, A.J., Haddad, T., Isaacs, C., Pusztai, L., Albain, K., Nanda, R., Tripathy, D., Liu, M.C., Boughey, J., Schwab, R., Hylton, N., DeMichele, A., Perlmutter, J., Yee, D., Berry, D., van't Veer, L., Valero, V., Esserman, L.J., and Symmans, W.F.

Published
2021
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6. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

Author

Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Good Health and Well Being, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

[This corrects the article DOI: 10.1186/s13054-016-1208-6.].

Published
2016

7. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

Author

Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, Tridente, A, and Nee, P

Subjects
Emergency & Critical Care Medicine, Medical and Health Sciences
Published
2016

8. 132P Neoadjuvant zanidatamab for stage I node-negative HER2- positive breast cancer (BC)

Author

Valero, V., primary, Mouabbi, J., additional, Alonzo, H., additional, Ilheme, A. Nwosu, additional, Murthy, R., additional, Huang, X., additional, Qiao, W., additional, Patel, M., additional, Pohlmann, P.R., additional, Rauch, G., additional, Checka, C., additional, Hunt, K., additional, Tripathy, D., additional, Meric-Bernstam, F., additional, and Symmans, F., additional

Published
2023
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9. SETER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer

Author

Sinn, Bruno V., Fu, Chunxiao, Lau, Rosanna, Litton, Jennifer, Tsai, Tsung-Heng, Murthy, Rashmi, Tam, Alda, Andreopoulou, Eleni, Gong, Yun, Murthy, Ravi, Gould, Rebekah, Zhang, Ya, King, Tari A., Viale, Agnes, Andrade, Victor, Giri, Dilip, Salgado, Roberto, Laios, Ioanna, Sotiriou, Christos, Marginean, Esmeralda C., Kwiatkowski, Danielle N., Layman, Rachel M., Booser, Daniel, Hatzis, Christos, Vicente Valero, V., and Fraser Symmans, W.

Published
2019
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10. 191P Correlation of early change in standardized uptake value (SUV) on positron emission tomography (PET/CT) with recurrence-free survival (RFS) and overall survival (OS) in patients with primary operable HER2-positive breast cancer (TBCRC026)

Author

Hennessy, M.A., primary, Leal, J., additional, Huang, C-Y., additional, Solnes, L., additional, Denbow, R., additional, Abramson, V., additional, Carey, L., additional, Liu, M.C., additional, Rimawi, M., additional, Specht, J., additional, Storniolo, A.M.V., additional, Valero, V., additional, Vaklavas, C., additional, Winer, E., additional, Krop, I., additional, Wolff, A.C., additional, Cimino-Mathews, A., additional, Wahl, R., additional, Stearns, V., additional, and Connolly, R.M., additional

Published
2022
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11. Open-label randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC versus the combination of paclitaxel and everolimus followed by FEC in women with triple receptor-negative breast cancer

Author

Gonzalez-Angulo, A.M., Akcakanat, A., Liu, S., Green, M.C., Murray, J.L., Chen, H., Palla, S.L., Koenig, K.B., Brewster, A.M., Valero, V., Ibrahim, N.K., Moulder-Thompson, S., Litton, J.K., Tarco, E., Moore, J., Flores, P., Crawford, D., Dryden, M.J., Symmans, W.F., Sahin, A., Giordano, S.H., Pusztai, L., Do, K.-A., Mills, G.B., Hortobagyi, G.N., and Meric-Bernstam, F.

Published
2014
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21. Analysis of the Environmental Impacts of Different Options for Energy Utilisation of Cork Residues

Author

Romero, P., Teresa Miranda, Valero, V., García, R., Arranz, J. I., Sepúlveda, F. J., and Montero, I.

Subjects
Biomass
Abstract

Extremadura is one of the most important cork producers. The processing and transformation of this raw material into finished products results in the generation of various types of waste. It is key that waste is revalued by recovering and reusing it for other purposes to conserve the environment while maximizing the benefits of the Circular Economy. On the other hand, this contributes to the implementation of the Waste Framework Directive (2008/98/EC) following the objectives and targets of the Roadmap for a Resource Efficient Europe, in line with the 2030 Agenda adopted by the United Nations. This study analyses the impact of different waste recovery options from a cork industry located in the region of Extremadura from an environmental perspective. For this purpose, a life cycle assessment (LCA) was carried out. The functional unit selected was the production of 1 MJ of primary energy through the recovery of cork with the different technologies studied, and a final comparison was made between them. CO2 emissions balance of any of the cork waste treatment options can be considered very positive, ranging between 95 and 170 kg CO2 eq. The effective impact of the correct management of waste to produce energy can be seen., Proceedings of the 30th European Biomass Conference and Exhibition, 9-12 May 2022, Online, pp. 368-376

Published
2022
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22. Physicians' attitudes and perceived barriers to adherence to the national breast cancer clinical practice guidelines in Mexico: a survey study

Author

Martinez-Cannon B, Soto-Perez-de-Celis E, Valle-Solis A, Arce-Salinas C, Bargallo-Rocha E, Bautista-Pina V, Cervantes-Sanchez G, Flores-Balcazar C, Tamburrino M, Lluch A, Maffuz-Aziz A, Perez-Sanchez V, Poitevin-Chacon A, Salas-Gonzalez E, Torres L, Valero V, Villasenor-Navarro Y, and Cardenas-Sanchez J

Subjects
Breast cancer, Low- and middle-income countries, Adherence, Clinical practice guidelines, Limited-resource settings
Abstract

Background Adherence to clinical practice guidelines improves outcomes for patients with breast cancer. However, their implementation may not be feasible in low- and middle-income countries. This study aimed to evaluate physicians' adherence, attitudes, and barriers towards the Colima Consensus, which is the Mexican national breast cancer clinical practice guideline. Methods A cross-sectional, 31-item survey was e-mailed to Consensus attendees and members of the Mexican Society of Oncology and Mexican Mastology Association. Descriptive statistics, univariate, and multivariate analysis were used to analyze the associations between participants' characteristics, adherence, attitudes, and barriers. Results Of 439 respondents, 78% percent adhered to Consensus recommendations and 94% believed it was applicable to their clinical practice. Forty percent reported using the Consensus as their sole breast cancer guideline. This was associated with being a surgical oncologist (OR 3.3, 95% CI 2.0-5.3) and practicing at a public hospital (OR 2.1, 95% CI 1.2-3.7). The most common barriers to adherence were lack of resources and logistical problems. Regarding attitudes towards the Consensus, 90% considered it a good educational tool, 89% considered it a reliable source of information, and 90% thought it improved quality of care. Conclusions We showed high levels of adherence and positive attitudes towards the Colima Consensus, with a significant proportion of physicians using it as their only guideline. Lack of resources and logistical issues were the main barriers to adherence. Our results highlight the relevance of local breast cancer guidelines and suggest a need for the creation of resource-stratified guidelines.

Published
2022

27. Local Therapy Outcomes and Toxicity From the ATEMPT Trial (TBCRC 033), a Phase II Randomized Trial of Adjuvant T-DM1 vs. TH in Women With Stage I HER2 Positive Breast Cancer

Author

Bellon, J.R., primary, Tayob, N., additional, Burstein, H.J., additional, Partridge, A., additional, Demeo, M.K., additional, Tralins, J., additional, Yang, D.D., additional, Dang, C., additional, Isakoff, S.J., additional, Yardley, D., additional, Valero, V., additional, Winer, E., additional, Krop, I., additional, and Tolaney, S., additional

Published
2021
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32. Identifikation von Brustkrebspatientinnen mit einer pathologischen Komplettremission in der Brust nach neoadjuvanter Systemtherapie mittels intelligenter vakuum-assistierter Biopsie

Author

Pfob, A, additional, Sidey-Gibbons, C, additional, Lee, HB, additional, Tasoulis, MK, additional, Koelbel, V, additional, Golatta, M, additional, Rauch, GM, additional, Smith, BD, additional, Valero, V, additional, MacNeill, F, additional, Han, W, additional, Weber, WP, additional, Rauch, G, additional, Kuerer, HM, additional, and Heil, J, additional

Published
2021
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38. The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner

Author

Hurtado-Bagès S, Posavec Marjanovic M, Valero V, Malinverni R, Corujo D, Bouvet P, Lavigne AC, Bystricky K, and Buschbeck M

Subjects
gene regulation, myogenic differentiation, ADP ribose, macroH2A, PARP1, cell fusion, histone variants, myotubes
Abstract

MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions. We have parted from the initial observation that loss of total macroH2A1 led to a change in the morphology of murine myotubes differentiated ex vivo. The fusion of myoblasts to myotubes is a key process in embryonic myogenesis and highly relevant for muscle regeneration after acute or chronic injury. We have focused on this physiological process, to investigate the functions of the two splice isoforms of macroH2A1. Individual perturbation of the two isoforms in myotubes forming in vitro from myogenic C2C12 cells showed an opposing phenotype, with macroH2A1.1 enhancing, and macroH2A1.2 reducing, fusion. Differential regulation of a subset of fusion-related genes encoding components of the extracellular matrix and cell surface receptors for adhesion correlated with these phenotypes. We describe, for the first time, splice isoform-specific phenotypes for the histone variant macroH2A1 in a physiologic process and provide evidence for a novel underlying molecular mechanism of gene regulation.

Published
2020

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