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Seyed Ahmad Hosseini,1 Maryam Vali,2 Mohammad Hossein Haghighi-Zade,3 Amir Siahpoosh,4 Reza Malihi5 1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Paramedical Sciences, Arvand International Division, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Nutrition, Abadan Faculty of Medical Sciences, Abadan, IranCorrespondence: Reza Malihi Tel +989 166051161Email r.malihi@abadanums.ac.irPurpose: Diabetes can increase oxidative stress in various tissues of the body, and the progress of this process is associated with intensification of the complications of diabetes. The current study purposed to evaluate the protective effect of Pinus gerardiana (PG) seed on oxidative stress induced by diabetes in the liver and serum of streptozotocin (STZ)-induced diabetic rats.Materials and Methods: This interventional study was performed on 36 male Wistar rats. The rats were randomly divided into 6 groups (healthy controls, healthy treated with 3% and 6% (PG), diabetic control, diabetic treated with 3% and 6% (PG) doses). After 6 weeks of intervention, weight, glucose, and oxidative stress parameters in serum and liver including total antioxidant capacity, malondialdehyde, total thiol and superoxide dismutase activity were measured. Data analysis was done by statistical software version 16 and Tukey’s one-way ANOVA tests.Results: Diabetic rats showed significantly higher malondialdehyde and fasting glucose levels (12± 1.2 mmol/L) and significant reductions in fasting insulin serum, weight (− 37%), and activity of superoxide dismutase enzymes, total thiol groups, and total antioxidant capacity of serum and liver (about +49% in liver and +16% in serum) (p < 0.001) compared with the healthy groups. Oral administration of PG nuts to diabetic rats caused a significant reduction in malondialdehyde and fasting glucose levels (− 43%) and weight loss (+15%), and a significant increase in activity of superoxide dismutase enzymes, total thiol groups, and total antioxidant capacity of serum and liver (p < 0.001).Conclusion: The present study concluded that PG can decrease fasting blood glucose, improve insulin resistance, reduce weight loss, and improve oxidative stress indices in the serum and liver of STZ-induced diabetic rats. It is a potential therapeutic food supplement for the treatment and prevention of hyperglycemia and high oxidative stress of diabetes.Keywords: diabetes mellitus, Pinus gerardiana, oxidative stress, blood glucose, rat

One-dimensional Dirac-type operator Dy = By' +P(x)y, y = (y1, y2)T, is considered in this work, where B = (...), b2 < 0 < b1, P(x) = diag(p1(x), p2(x)) and pj(x), j = 1,2 are the complex-valued functions defined on the arbitrary finite interval G = (a, b) of the real axis with pj(x) ∈ L1(G), j = 1, 2. We establish antiapriori estimates for associated vector functions. We also prove criterion of Bessel property and unconditional basis property for the systems of root vector functions of the operator D in L2² (G). [ABSTRACT FROM AUTHOR]

Abstract Background Glucomannan has been studied for various health benefits, but its effects on lipid profile in adults are not well understood. This meta-analysis aims to evaluate the impact of glucomannan supplementation on serum/plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), Apo B1, Apo A1, APO-B/ A1 ratio, and LDL-C/ HDL-C in adults. Methods A comprehensive search was conducted across Scopus, PubMed, Embase, and Web of Science from inception to June 2024 to identify randomized controlled trials (RCTs) assessing glucomannan supplementation on lipid profile in adults. Data were extracted and analyzed using random effects model to determine the standardized mean differences (SMDs) and 95% confidence intervals (CIs) for each biomarker. Results Glucomannan supplementation significantly decreased TC (SMD: -3.299; 95% CI: -4.955, -1.664, P

Background: Patients with non-alcoholic fatty liver disease (NAFLD) benefit from using synbiotics. However, findings from existing trials remain contentious. Therefore, this meta-analysis evaluated the effects of synbiotics on liver enzymes, blood pressure, inflammation, and lipid profiles in patients with NAFLD. Methods: We searched PubMed, Embase, Cochrane, Scopus, and Web of Science for randomized controlled trials (RCTs) regarding synbiotics supplementation in patients with NAFLD. Results: The meta-analysis revealed that synbiotics supplementation significantly improved liver enzymes (AST, WMD: −9.12 IU/L; 95 % CI: −13.19 to −5.05; ALT, WMD: −8.53 IU/L; 95 % CI: −15.07 to −1.99; GGT, WMD: −10.42 IU/L; 95 % CI: −15.19 to −5.65), lipid profile (TC, WMD: −7.74 mg/dL; 95 % CI: −12.56 to −2.92), obesity indices (body weight, WMD: −1.95 kg; 95 % CI: −3.69 to −0.22; WC, WMD: −1.40 cm; 95 % CI: −2.71 to −0.10), systolic blood pressure (SBP, WMD: −6.00 mmHg; 95 % CI: −11.52 to −0.49), and inflammatory markers (CRP, WMD: −0.69 mg/L; 95 % CI: −1.17 to −0.21; TNF-α, WMD: −14.01 pg/mL; 95 % CI: −21.81 to −6.20). Conclusion: Overall, supplementation with synbiotics positively improved liver enzymes, obesity indices, and inflammatory cytokines in patients with NAFLD.

Objective: Flaxseed (Linum usitatissimum) supplementation has shown promise as an anti-obesity agent in various clinical trials, although results have been inconsistent. To provide a more accurate assessment of the impact of flaxseed supplementation on anthropometric indices, a systematic review and meta-analysis was performed. Methods: We searched several international databases until August 2023, including Scopus, PubMed, Web of Science, Embase, and Cochrane Library. Weighted mean differences (WMDs) were analyzed using a random-effects model. Results: Sixty-four trials comprising 72 treatment arms were included. All studies reported the intervention types (Lignans, Whole flaxseed, and Flaxseed oil) and dosage. However, three studies did testing for purity, and 40 studies reported potency. Also, the risk of contamination with heavy metals was not mentioned in studies. Another limitation was the lack of blind evaluation in the studies. According to three trials included in the systematic review, flaxseed did not affect anthropometric indices. Our meta-analysis revealed significant reductions in body weight (WMD = −0.63 kg; 95 % CI: −1.00, −0.27, P 30 kg/m2) showed more significant anti-obesity effects. Based on the GRADE evaluation, body weight, BMI, and WC results were considered as moderate-certainty evidence. Conclusion: Our systematic review and meta-analysis suggests that supplementation with flaxseed (Linum usitatissimum) leads to meaningful improvements in body weight, BMI, and WC. Therefore, flaxseed can be considered as an adjunctive therapeutic approach in improving obesity

Abstract Overpressure is always considered as a severe problem in the oil industry. Besides creating life risks through serious accidents while drilling, failure to correctly identify high-pressure intervals causes a significant increase in costs and prolongs the drilling process. Kazhdumi Formation in the Abadan Plain is considered as a high-pressure formation in several wells. Various reasons can cause overpressure problem. Hydrocarbon generation is one cause of abnormal pressure in source rocks. Understanding hydrocarbon generation potential can be a helpful approach since the Kazhdumi Formation is considered as a probable source rock in this area. In this paper, in order to better understand the problem of abnormal pressure in Kazhdumi Formation, geochemical concepts and tools have been applied. To that way, 1D petroleum system modeling of five wells was done, and the thermal maturity level of Kazhdumi Formation was determined and then, compared with drilling records. The results indicate that in wells where this formation has sufficient organic matter and has reached an early mature level, there is an abnormal pressure problem. Otherwise, this formation does not show abnormal pressure. Also, geochemical data are not available in all drilled wells, which makes impossible the assessing of hydrocarbon generation role. Therefore, petrophysical well logs (sonic (DT), neutron (NPHI), density (RHOB), spectral gamma ray (SGR), and resistivity (RES)) as well as 137 sets of geochemical data belonging to 13 wells from 7 oilfields in the Abadan Plain were used to predict geochemical indicators. Using artificial neural networks, geochemical data of a well in Abadan Plain were predicted. This selected well has a high-pressure problem in Kazhdumi Formation, but no geochemical data are available in this well. The results of predicted geochemical data show that the high-pressure phenomenon in this well may also be due to hydrocarbon generation. The precise understanding of the abnormal pressure, resulting from hydrocarbons generation, requires comprehensive studies and a full investigation of the studied area. However, the results of this paper help to predict approximately the behavior of the source rocks before drilling. Acquiring this overview will aid in reducing drilling hazards and costs.

Integrated reservoir rock typing in carbonate reservoirs is a significant step in reservoir modelling. The key purpose of this study is the identification of integrated rock types in the Sarvak Formation of an Iranian oilfield. In this study, electrofacies (EFAC) analysis of the Sarvak reservoir was done in detail to determine the reservoir quality and rock types of the Sarvak Formation in the studied field. The core data and conventional petrophysical logs were used for rock typing. Some petrophysical logs such as porosity, sonic, neutron, density, and Photo electric factor were applied as input data for electrofacies analysis. Multi-Resolution Graph-Based Clustering was used among six approaches, resulting in four electrofacies after merging similar clusters. EFAC-1 has the lowest porosity, and EFAC-4 has the highest porosity. In addition, based on Winland and Amaefule approaches, three rock types were determined using core data (porosity and permeability). As a result, three rock types were defined; rock type-1 has the smallest pore-throat size and flow zone indicator while rock type-3 has the highest ones. The correlation coefficient between permeability and porosity in each rock type is more than 80%. Rock type 1 is mainly composed of EFAC-1 and EFAC-2, while rock types 2 and 3 share mostly the EFACs 1, 3 and 4.

Abstract Cyclone Idai in 2019 was one of the worst tropical cyclones recorded in the Southern Hemisphere. The storm caused catastrophic damage and led to a humanitarian crisis in Mozambique. The affected population suffered a cholera epidemic on top of housing and infrastructure damage and loss of life. The housing and infrastructure damage sustained during Cyclone Idai still has not been addressed in all affected communities. This is of grave concern because storm damage results in poor housing conditions which are known to increase the risk of malaria. Mozambique has the 4th highest malaria prevalence in sub-Saharan Africa and is struggling to control malaria in most of the country. We conducted a community-based cross-sectional survey in Sussundenga Village, Manica Province, Mozambique in December 2019-February 2020. We found that most participants (64%) lived in households that sustained damage during Cyclone Idai. The overall malaria prevalence was 31% measured by rapid diagnostic test (RDT). When controlling for confounding variables, the odds of malaria infection was nearly threefold higher in participants who lived in households damaged by Cyclone Idai nearly a year after the storm. This highlights the need for long-term disaster response to improve the efficiency and success of malaria control efforts.

Most adult Cystic Fibrosis (CF) patients frequently suffer from Pseudomonas aeruginosa (PA) infection, which is strongly associated with inammation, lung destruction, and increased mortality. Diagnosis of PA infection in the primary stage is essential to initiate the treatment and reduce the risk of chronic infection. Sputum culture is the gold standard for infection detection, but it is time consuming. The objective of this study was to suggest and examine a method to determine PA infection status in CF patients based only on their respiratory sound. Respiratory sounds were recorded from 36 CF patients. Some features which were generated from Tunable Q-factor Wavelet Transform (TQWT) components were investigated. The features were fed into Support Vector Machine and Ensemble classifier. The proposed method achieved an accuracy rate of 90.3% in identifying PA infection in CF patients. Furthermore, the probability of categorizing respiratory sounds as PA CF decreased significantly after the treatment of PA infection (P-value < 0.003). Moreover, the method exhibited a satisfactory performance in the presence of noises and artifacts. The developed method represents a novel approach to the diagnosis of PA infection in CF patients based only on respiratory sound signals, which is a necessary and innovative approach to early diagnosis of PA infection. [ABSTRACT FROM AUTHOR]

Introduction: Adolescents with post-traumatic stress disorder (PTSD) exhibit heightened sensitivity to environmental hazards, and face difficulties in emotion regulation and academic self-regulation. The present study aimed to investigate the effectiveness of trauma-focused cognitive-behavioral therapy on emotion regulation and academic self-regulation in adolescent girls with clinical symptoms of post-traumatic stress disorder following a traumatic event.Methods: The research method in this study was a quasi-experimental design with pre-test and post-test measures, including a control group. A total of 20 female students from the high school in Zahedan in the year 2021 were purposefully selected and randomly assigned to two groups: the experimental group (10 participants) and the control group (10 participants). Trauma-focused cognitive-behavioral therapy was administered to the experimental group over 11 ninety-minute sessions. The data collection tools included the Pekran et al. (2002) Academic Emotion Questionnaire, the Kiano et al. (1987) Post-Traumatic Stress Disorder (PTSD) Questionnaire, and the Zimmerman and Martinez-Pons (1986) Academic Self-Regulation Questionnaire. Data analysis involved the use of both univariate and multivariate analysis of covariance (ANCOVA).Results: The findings indicated a significant difference between the mean scores of academic emotions and academic self-regulation in the experimental and control groups at the post-test phase, with a 95% confidence level (P

Abstract Reservoir quality in carbonate reservoirs is significantly influenced by diagenetic processes. Although diagenesis is studied as a common reservoir quality damaging/enhancing process in many previous studies, literature is limited about the spatial modeling of diagenesis processes using advanced geostatistical algorithms. In the current study, 3D models of the main diagenetic processes which affect the reservoir quality of the Sarvak reservoir in an Iranian oilfield located in the north Dezful Embayment were constructed using geostatistics. According to the petrographic studies, a total of 10 microfacies were identified. In addition, the significant diagenetic processes in this reservoir include dolomitization, cementation, dissolution, and compaction. In this study, diagenetic electrofacies were determined using the “multi-resolution graph clustering” method based on the quantitative results of the petrographic studies. The results of spatial modeling and provided average maps were used to investigate the lateral variation of those properties and their relationship with effective porosity. It shows that trends of the secondary porosity and velocity deviation log (VDL) maps are generally correlatable with the effective porosity maps confirming the impact of dissolution as a main significant diagenetic process on reservoir quality enhancement. The most impact of the dissolution on porosity is observed in Lower Sarvak-E2 zone where the correlation coefficient is 0.75. The correlation coefficient between porosity and VDL in some zones is high indicating the effect of diagenesis on reservoir quality as it exceeds 0.61 in Lower Sarvak-A1 zone. In the occurrence of dolomitization, it has dual constructive and destructive effects on the reservoir quality. The most constructive and destructive effects of dolomitization were observed in Lower Sarvak-E1 and Lower Sarvak-F zones in which the correlation coefficients were 0.476 and − 0.456, respectively. In addition, low porosity zones are correlatable with developing cementation, stylolites, and solution seams.

Abstract Background Several meta-analyses reported glycemic-lowering effects of cinnamon, while others reported conflicting findings. In the present study, we aimed to perform an umbrella meta-analysis of previous interventional meta-analyses on the effects of cinnamon on glycemic control in patients with type 2 diabetes (T2D) or with polycystic ovary syndrome (PCOS). Methods Relevant studies were searched in PubMed, Scopus, EMBASE, Web of Science, and Google Scholar up to June 2022. Meta-analyses of randomized clinical trials (RCTs) investigating the effects of cinnamon on glycemic indices including fasting plasma glucose (FPG), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, and hemoglobin A1C (HbA1c) were included. Random-effects models were used to perform the umbrella meta-analysis and pool the weighted mean difference (WMD) or standardized mean difference (SMD) and their 95% confidence intervals (CI). Results Overall, 11 meta-analyses of RCTs were included. Cinnamon supplementation was effective in reducing serum FPG (WMD: -10.93 mg/dL; 95%CI: -16.22, -5.65; SMD: -0.86; 95%CI: -1.19, -0.52), insulin (WMD: -2.01 IU/mL; 95%CI: -3.96, -0.07; SMD: -0.61; 95%CI: -0.93, -0.30), HOMA-IR levels (WMD: -0.61; 95%CI: -0.91, -0.31; SMD: -0.78; 95%CI: -1.26, -0.30), and HbA1c (WMD: -0.10%; 95%CI: -0.17, -0.03). Conclusion Cinnamon can be used as an anti-diabetic agent and an add-on treatment to control glycemic indices among patients with T2D or PCOS.

Abstract Objectives: Several meta-analyses have suggested the beneficial effect of vitamin D on patients infected with severe acute respiratory syndrome coronavirus-2. This umbrella meta-analysis aims to evaluate influence of vitamin D supplementation on clinical outcomes and the mortality rate of COVID-19 patients. Design: Present study was designed as an umbrella meta-analysis. The following international databases were systematically searched till March 2023: Web of Science, PubMed, Scopus, and Embase. Settings: Random-effects model was employed to perform meta-analysis. Using AMSTAR critical evaluation tools, the methodological quality of the included meta-analyses was evaluated. Participants: Adult patients suffering from COVID-19 were studied. Results: Overall, 13 meta-analyses summarising data from 4 randomised controlled trial and 9 observational studies were identified in this umbrella review. Our findings revealed that vitamin D supplementation and status significantly reduced mortality of COVID-19 [Interventional studies: (ES = 0·42; 95 % CI: 0·10, 0·75, P < 0·001; I 2 = 20·4 %, P = 0·285) and observational studies (ES = 1·99; 95 % CI: 1·37, 2·62, P < 0·001; I 2 = 00·0 %, P = 0·944). Also, vitamin D deficiency increased the risk of infection and disease severity among patients. Conclusion: Overall, vitamin D status is a critical factor influencing the mortality rate, disease severity, admission to intensive care unit and being detached from mechanical ventilation. It is vital to monitor the vitamin D status in all patients with critical conditions including COVID patients.

Abstract Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p

Recent randomized controlled trials (RCTs) have shown that flaxseed supplementation beneficially improves glycemic control; however, there is no consensus on this issue. In this systematic review and meta-analysis, we aimed to investigate the effect of flaxseed and its products on glycemic control in adults. We searched PubMed, Scopus, Embase, Web of Science databases, and Google Scholar till December 2022. Finding from forty-seven RCTs revealed that flaxseed supplementation had a statistically significant reduction in FBS (SMD: −0.66; 95% CI: −0.96, −0.35), HOMA-IR (SMD: −0.64; 95% CI: −1.02, −0.26), and insulin (SMD: −0.49; 95% CI: −0.80, −0.17). Besides, QUICKI increased significantly (SMD: 1.64; 95% CI: 1.13, 2.14) following flaxseed supplementation. Additionally, flaxseed did not change the HbA1c (SMD: −0.47; 95% CI: −0.97, 0.04) significantly. The present meta-analysis suggests flaxseed supplementation can improve FBS, QUIKI, HOMA-IR, and insulin levels but not HbA1c. Overall, flaxseed can be used as an adjuvant anti-hyperglycemic agent.

Inconsistent data suggest that flaxseed supplementation may have a role in sex hormones. We aimed to carry out a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating effects of flaxseed supplementation on sex hormone profile. PubMed, Scopus, Embase, Cochrane Library, Web of Science databases, and Google Scholar were searched up to March 2023. Standardized mean difference (SMD) was pooled using a random-effects model. Sensitivity analysis, heterogeneity, and publication bias were reported using standard methods. The quality of each study was evaluated with the revised Cochrane risk-of-bias tool for randomized trials, known as RoB 2. Finding from ten RCTs revealed that flaxseed supplementation had no significant alteration in follicle-stimulating hormone (FSH) (SMD: −0.11; 95% CI: −0.87, 0.66: p = 0.783), sex hormone-binding globulin (SHBG) (SMD: 0.35; 95% CI: −0.02, 0.72; p = 0.063), total testosterone (TT) levels (SMD: 0.17; 95% CI: −0.07, 0.41; p = 0.165), free androgen index (FAI) (SMD = 0.11, 95% CI: −0.61, 0.83; p = 0.759), and dehydroepiandrosterone sulfate (DHEAS) (SMD: 0.08, 95%CI: −0.55, 0.72, p = 0.794). Flaxseed supplementation had no significant effect on sex hormones in adults. Nevertheless, due to the limited included trials, this topic is still open and needs further studies in future RCTs.

IntroductionThe findings of randomized controlled trials (RCTs) regarding the effect of flaxseed on adipokine concentrations are conflicting. Therefore, the present meta-analysis was conducted to provide definite and conclusive results.MethodsSystematically, Scopus, Embase, PubMed, Web of Science databases, and Google Scholar were searched for relevant literature published up to December 2022. Based on random-effect models, standard mean differences (SMDs) were calculated for net changes in adipokine concentrations.ResultsOverall, 13 RCTs (15 arms) were eligible to be included. The results indicated that leptin was significantly reduced after the intervention with flaxseed supplement (SMD = −0.69, 95% CI: −1.37, −0.01; p = 0.048; I2 = 92.0%, p < 0.001). In addition, flaxseed supplements had no considerable effect on plasma adiponectin (SMD = 0.52, 95% CI: −0.20, 1.25, p = 0.159; I2 = 92.0%, p < 0.001).DiscussionFlaxseed significantly improves leptin but does not affect adiponectin concentrations. Additional future well-designed trials are required to further assess the potential benefits of flaxseed on adipokines in humans.

IntroductionPrevious meta-analyses investigating the therapeutic effects of L-carnitine on lipid profiles have demonstrated inconsistent results. The present umbrella meta-analysis aimed to investigate the impact of efficacy of L-carnitine on lipid profiles in adults.MethodsDatabases including PubMed, Scopus, and Embase, Web of Science, and Google Scholar were searched up to June 2023. Meta-analysis was performed using a random-effects model.ResultsOur results from thirteen meta-analyses indicated that L-carnitine supplementation significantly total cholesterol (TC) (ES = −1.05 mg/dL, 95% CI: −1.71, −0.39; p = 0.002), triglycerides (TG) (ES = −2.51 mg/dL; 95% CI: −3.62, −1.39, p

The scientific atmosphere in the modern world needs transformational leaders who can lead universities towards a better performance consistent with their specific requirements. This study aimed to investigate the effect of internal control systems on the intensity of organizational performance and innovation with a moderating role of transformational leadership. The research method was Structural Equation Modelling (SEM) and the statistical population included all employees of Tehran Payame Noor University in 2022 where 301 people were randomly selected and completed questionnaires. For data collection, the researcher-made questionnaire was used with acceptable reliability and validity. The findings showed that internal control systems have a significant direct and indirect impact on the intensity of organizational performance and innovation at an error level of 0

We consider one-dimensional Dirac operator with a summable potential on the interval G = (0; 2π). Componentwise uniform equiconvergence rate of spectral expansion for absolutely continuous function and trigonometric Fourier series is estimated on a compact. [ABSTRACT FROM AUTHOR]

Background and Objectives: Promoting emotion regulation and social relationships has a key role in students' health and can affect their future success. Therefore, the present study was conducted to determine the effect of play-based education on students' emotional regulation and social relationships. Materials and Methods: This quasi-experimental, pre-test-post-test study, included all female students of the second and third grades of Zahedan city in the academic year 2021-2022. Thirty patients were selected by purposive sampling and randomly assigned to two groups of 15; experimental and control. The participants answered the Gross & John (2003) Social Relations Regulation Questionnaire, Barton et al. (2006). The experimental group participated in 12 play therapy sessions, but the control group did not receive any intervention. Data were analyzed by multivariate analysis of covariance. Results: The results showed that there was a significant difference between the control and experimental groups in post-test in terms of emotion regulation and students' social relationships (P < 0.001). Conclusions: Game education was effective in improving students 'emotional regulation and social relationships, so play therapy can be used to improve students' emotion regulation and social relationships.

IntroductionNumerous meta-analyses have demonstrated the beneficial effects of probiotics on oxidative stress biomarkers, although some studies have contradictory results. Therefore, the current research was conducted to obtain a precise and definite understanding on the impact of probiotics on oxidative stress biomarkers in adults.MethodsWe conducted a comprehensive systematic search of results on Scopus, PubMed, Embase, Web of Science, and Google Scholar dating up to March 2022. Fifteen meta-analyses were included in this umbrella meta-analysis. The random-effects model was employed to obtain the overall effect size. Subgroup analyses were carried out based on supplementation dosage and duration, mean age, and study population.ResultsOur results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ESWMD = −0.56, 95% CI: −0.72, −0.39; p < 0.001, and ESSMD = −0.50, 95% CI: −0.66, −0.34; p < 0.001). Moreover, the findings showed that probiotics resulted in a significant increase in total antioxidant capacity (TAC) (ESWMD = 29.18, 95% CI: 16.31, 42.04; p < 0.001, and ESSMD = 0.25, 95% CI: 0.02, 0.47; p = 0.032), total glutathione (GSH) (ESWMD: 30.65; 95% CI: 16.94, 44.35, p < 0.001), and nitric oxide (NO) (ESWMD: 1.48; 95% CI: 0.31, 2.65, p = 0.013; I2 = 51.7%, p = 0.043).DiscussionProbiotics could be considered a strong agent in the reinforcement of antioxidant status and preventing the incidence of chronic diseases.

Introduction: Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other studies reject such effects.Methods: Therefore, in this umbrella meta-analysis, we performed a comprehensive systematic search in such databases as Web of Science, PubMed, Scopus, Embase, and Google Scholar up to January 2023.Results: Based on standardized mean difference analysis, CoQ10 supplementation significantly decreased serum C-reactive protein (CRP) (ESSMD = −0.39; 95% CI: 0.77, −0.01, p = 0.042) and malondialdehyde (MDA) (ESSMD = −1.17; 95% CI: 1.55, −0.79, p < 0.001), while it increased the total antioxidant capacity (TAC) (ESSMD = 1.21; 95% CI: 0.61, 1.81, p < 0.001) and serum superoxide dismutase (SOD) activity (ESSMD = 1.08; 95% CI: 0.37, 1.79, p = 0.003). However, CoQ10 supplementation had no significant reducing effect on tumor-necrosis factor-alpha (TNF- α) (ESSMD = −0.70; 95% CI: 2.09, 0.68, p = 0.320) and interleukin-6 (IL-6) levels (ESSMD = −0.85; 95% CI: 1.71, 0.01, p = 0.053). Based on weighted mean difference analysis, CoQ10 supplementation considerably decreased TNF-α (ESWMD = −0.46, 95% CI: 0.65, −0.27; p < 0.001), IL-6 (ESWMD = −0.92, 95% CI: 1.40, −0.45; p < 0.001), and CRP levels (effect sizes WMD = −0.28, 95% CI: 0.47, −0.09; p < 0.001).Discussion: The results of our meta-analysis supported the alleviating effects of CoQ10 on markers of inflammation cautiously. However, CoQ10 had antioxidant effects regarding the improvement of all the studied antioxidant and oxidative stress biomarkers.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323861, identifier CRD42022323861

Inconsistent data are available about the effect of royal jelly supplementation on anthropometric indices in humans. This systematic review and meta-analysis was done to summarize data from available randomized controlled trials (RCTs) on the effect of royal jelly supplementation on anthropometric indices such as body weight (BW), body mass index (BMI), and fat mass (FM) in adults. We systematically searched Embase, PubMed, Web of Science, and Scopus databases up to March 2023. All RCTs assessing the effect of royal jelly on anthropometric indices were included. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CIs). Sensitivity and subgroup analyses were also performed. Out of 1,492 records, 10 studies that enrolled 512 participants were included. There was no significant effect on BW (WMD: −0.29 kg, 95% CI: −1.24, 0.65, p = 0.543), BMI (WMD: 0.11 kg/m2, 95% CI: −0.29, 0.52, p = 0.583), and FM (WMD: 0.02%, 95% CI: −0.41, 0.46, p = 0.84). However, we observed a reduction in BW and BMI following royal jelly intake in subgroup of royal jelly dosage

This study focuses on the intricate process of discerning productive layers within reservoir formations, taking the Sarvak Formation as a primary case. The employed methodology combines geology, comprehensive log interpretations, and petrophysical analyses to facilitate the evaluation of these productive layers. Initially, routine well logs are interpreted to determine key petrophysical parameters such as shale content, porosity, and water saturation. Subsequently, core measurement results are utilized for calibrating these log interpretations. The study further determines cut-off values through a calculated method of 5% cumulative hydrocarbon volume against porosity, shale content, and water saturation. These cut-off values are then applied to the petrophysical results to enhance their reliability. To resolve any inconsistencies or uncertainties in petrophysical evaluation, petrographical analyses, including scanning electron microscope imaging and thin section studies, are employed. The Sarvak Formation is categorized into seven distinct subzones, each thoroughly investigated to ascertain their respective productivity potential. The final results illustrate a substantial heterogeneity within the Sarvak Formation, revealing a range of diagenetic processes including compaction, dissolution, and cementation. Despite this complexity, three subzones are identified as the most productive layers with the maximum net pay, demonstrating the efficacy of the integrated approach.

Many studies have suggested that Nigella Sativa supplementation may exert a beneficial effect on anthropometric indices; however, the findings are inconclusive. Therefore, this study was conducted to obtain an updated finding in this regard. Systematic search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar, up to August 2022. N. sativa supplementation significantly reduced BW (WMD = −1.46 kg; 95 % CI: −2.53, −0.39) and BMI (WMD: −0.58 kg/m2, 95 % CI: −0.86, −0.29) compared to placebo group. However, no significant reductions were found in WC (WMD: −2.54 cm, 95 % CI: −6.27, 1.19), HC (WMD: −1.92 cm; 95 % CI: −4.38 to 0.54), and WHR (WMD = −0.03; 95 % CI: −0.07, 0.01). The current meta-analysis revealed that N. sativa supplementation in adults led to a significant decrease in body weight and BMI, but not WC, HC, and WHR. Thus, according to our findings, N. sativa supplementation can be recommended as an adjunctive intervention in obesity management.