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BACKGROUND: Inflammation is recognized in up to 50% of chronic kidney disease (CKD) patients, being a common feature of advanced renal disease and crucial mediator of vascular calcification which may be relevant in CKD. This study was aimed at evaluating the role of Growth arrest–specific 6 (Plasma GAS-6) and mineral metabolism abnormalities in hemodialysis patients. METHODS: We enrolled a total of 92 adults including 46 (28 males and 18 females) clinically stable hemodialysis patients (HD) and 46 (23 males and 23 females) patients with normal kidney as control group. Plasma GAS-6, interleukin 6 (IL-6), and high sensitivity C-reactive protein (hsCRP) concentration and biochemical alteration were quantified; as biochemical factors, GAS-6, interleukin 6(IL-6), and high-sensitivity C-reactive protein (hsCRP) levels were determined by standard methods. RESULTS: Levels of GAS-6 were significantly increased in hemodialysis (HD) patients compared with normal controls (P < 0.001). In HD patients, IL-6, and hsCRP levels were increased compared with controls (P < 0.001). The levels of GAS-6 were directly associated with IL-6 (r = 0.560, P < 0.001) in HD patients. No significant correlation was found between hsCRP and GAS-6 levels in HD patients (r = 0.05, P = 0.742). Multiple regression analysis demonstrated that serum P was independently associated with hsCRP and GAS-6 independently associated with IL-6. CONCLUSIONS: Elevated serum P and GAS-6 might play a role in the development of inflammation in CKD patients. Although our study shows that GAS-6 is directly associated with IL-6 and phosphor with hsCRP, their direct role in vascular calcification and type of their relationships need further studies in the future., Journal of Analytical Research in Clinical Medicine; EISSN