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5 results on '"Vallee, Ingrid"'

1. Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase

Author

de Potter, Bastiaan, primary, Vallee, Ingrid, additional, Camacho, Noelia, additional, Filipe Costa Póvoas, Luís, additional, Bonsembiante, Aureliano, additional, Pons i Pons, Alba, additional, Eckhard, Ulrich, additional, Gomis-Rüth, Francesc-Xavier, additional, Yang, Xiang-Lei, additional, Schimmel, Paul, additional, Kuhle, Bernhard, additional, and Ribas de Pouplana, Lluís, additional

Published
2023
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2. Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase

Author

Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Potter, Bastiaan de, Vallee, Ingrid, Camacho, Noelia, Costa Póvoas, Luís Filipe, Bonsembiante, Aureliano, Pons-Pons, Alba, Eckhard, Ulrich, Gomis-Rüth, F. Xavier, Yang, Xiang-Lei, Schimmel, Paul, Kuhle, Bernhard, Pouplana, Lluís Ribas de, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Potter, Bastiaan de, Vallee, Ingrid, Camacho, Noelia, Costa Póvoas, Luís Filipe, Bonsembiante, Aureliano, Pons-Pons, Alba, Eckhard, Ulrich, Gomis-Rüth, F. Xavier, Yang, Xiang-Lei, Schimmel, Paul, Kuhle, Bernhard, and Pouplana, Lluís Ribas de

Abstract

Through their aminoacylation reactions, aminoacyl tRNA-synthetases (aaRS) establish the rules of the genetic code throughout all of nature. During their long evolution in eukaryotes, additional domains and splice variants were added to what is commonly a homodimeric or monomeric structure. These changes confer orthogonal functions in cellular activities that have recently been uncovered. An unusual exception to the familiar architecture of aaRSs is the heterodimeric metazoan mitochondrial SerRS. In contrast to domain additions or alternative splicing, here we show that heterodimeric metazoan mitochondrial SerRS arose from its homodimeric ancestor not by domain additions, but rather by collapse of an entire domain (in one subunit) and an active site ablation (in the other). The collapse/ablation retains aminoacylation activity while creating a new surface, which is necessary for its orthogonal function. The results highlight a new paradigm for repurposing a member of the ancient tRNA synthetase family.

Published
2023

3. Supporting data associated with the manuscript: 'Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase'

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Potter, Bastiaan de, Vallee, Ingrid, Camacho, Noelia, Costa Póvoas, Luís Filipe, Bonsembiante, Aureliano, Pons-Pons, Alba, Eckhard, Ulrich, Gomis-Rüth, F. Xavier, Yang, Xiang-Lei, Schimmel, Paul, Kuhle, Bernhard, Pouplana, Lluís Ribas de, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Potter, Bastiaan de, Vallee, Ingrid, Camacho, Noelia, Costa Póvoas, Luís Filipe, Bonsembiante, Aureliano, Pons-Pons, Alba, Eckhard, Ulrich, Gomis-Rüth, F. Xavier, Yang, Xiang-Lei, Schimmel, Paul, Kuhle, Bernhard, and Pouplana, Lluís Ribas de

Published
2023

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