14 results on '"Vallette B"'
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2. Analysis of error in TOMS total ozone as a function of orbit and attitude parameters
- Author
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Gregg, W. W, Ardanuy, P. E, Braun, W. C, Vallette, B. J, Bhartia, P. K, and Ray, S. N
- Subjects
Meteorology And Climatology - Abstract
Computer simulations of orbital scenarios were performed to examine the effects of orbital altitude, equator crossing time, attitude uncertainty, and orbital eccentricity on ozone observations by future satellites. These effects were assessed by determining changes in solar and viewing geometry and earth daytime coverage loss. The importance of these changes on ozone retrieval was determined by simulating uncertainties in the TOMS ozone retrieval algorithm. The major findings are as follows: (1) Drift of equator crossing time from local noon would have the largest effect on the quality of ozone derived from TOMS. The most significant effect of this drift is the loss of earth daytime coverage in the winter hemisphere. The loss in coverage increases from 1 degree latitude for + or - 1 hour from noon, 6 degrees for + or - 3 hours from noon, to 53 degrees for + or - 6 hours from noon. An additional effect is the increase in ozone retrieval errors due to high solar zenith angles. (2) To maintain contiguous earth coverage, the maximum scan angle of the sensor must be increased with decreasing orbital altitude. The maximum scan angle required for full coverage at the equator varies from 60 degrees at 600 km altitude to 45 degrees at 1200 km. This produces an increase in spacecraft zenith angle, theta, which decreases the ozone retrieval accuracy. The range in theta was approximately 72 degrees for 600 km to approximately 57 degrees at 1200 km. (3) The effect of elliptical orbits is to create gaps in coverage along the subsatellite track. An elliptical orbit with a 200 km perigee and 1200 km apogee produced a maximum earth coverage gap of about 45 km at the perigee at nadir. (4) An attitude uncertainty of 0.1 degree in each axis (pitch, roll, yaw) produced a maximum scan angle to view the pole, and maximum solar zenith angle).
- Published
- 1991
3. Algebra + homotopy = operad
- Author
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Vallette, B.
- Published
- 2014
4. Rôle transformant du Polyomavirus de Merkel dans le carcinome de Merkel : une observation en faveur d'un mécanisme d'oncogénèse de type 'hit and run'
- Author
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Laude, H., Vallette, B., Cantero, M.L., Carlotti, Agnès, Audebourg, A., Meritet, J.F., Touzé, Antoine, Coursaget, Pierre, Avril, Marie-Françoise, Dupin, N., Rozenberg, F., ProdInra, Migration, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), and Institut National de la Recherche Agronomique (INRA)-Université de Tours
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2012
5. Manin products, Koszul duality, Loday algebras and Deligne conjecture : dedicated to Jean-Louis Loday, on the occasion of his sixtieth birthday
- Author
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Vallette, B.
- Published
- 2008
6. Caractéristiques du polyomavirus de Merkel dans des lignées de carcinome à cellules de Merkel au cours du temps
- Author
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Molet, L, primary, Cantero-Brassart, L, additional, Chantot-Bastaraud, S, additional, Nicco, C, additional, Vallette, B, additional, Valent, A, additional, Siffroi, JP, additional, Batteux, F, additional, and Rozenberg, F, additional
- Published
- 2014
- Full Text
- View/download PDF
7. MODIS information, data and control system (MIDACS) operations concepts
- Author
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Han, D, Salomonson, V, Ormsby, J, Ardanuy, P, Mckay, A, Hoyt, D, Jaffin, S, Vallette, B, Sharts, B, and Folta, D
- Subjects
Earth Resources And Remote Sensing - Abstract
The MODIS Information, Data, and Control System (MIDACS) Operations Concepts Document provides a basis for the mutual understanding between the users and the designers of the MIDACS, including the requirements, operating environment, external interfaces, and development plan. In defining the concepts and scope of the system, how the MIDACS will operate as an element of the Earth Observing System (EOS) within the EosDIS environment is described. This version follows an earlier release of a preliminary draft version. The individual operations concepts for planning and scheduling, control and monitoring, data acquisition and processing, calibration and validation, data archive and distribution, and user access do not yet fully represent the requirements of the data system needed to achieve the scientific objectives of the MODIS instruments and science teams. The teams are not yet formed; however, it is possible to develop the operations concepts based on the present concept of EosDIS, the level 1 and level 2 Functional Requirements Documents, and through interviews and meetings with key members of the scientific community. The operations concepts were exercised through the application of representative scenarios.
- Published
- 1988
8. MODIS information, data and control system (MIDACS) level 2 functional requirements
- Author
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Han, D, Salomonson, V, Ormsby, J, Sharts, B, Folta, D, Ardanuy, P, Mckay, A, Hoyt, D, Jaffin, S, and Vallette, B
- Subjects
Earth Resources And Remote Sensing - Abstract
The MODIS Information, Data and Control System (MIDACS) Level 2 Functional Requirements Document establishes the functional requirements for MIDACS and provides a basis for the mutual understanding between the users and the designers of the EosDIS, including the requirements, operating environment, external interfaces, and development plan. In defining the requirements and scope of the system, this document describes how MIDACS will operate as an element of the EOS within the EosDIS environment. This version of the Level 2 Requirements Document follows an earlier release of a preliminary draft version. The sections on functional and performance requirements do not yet fully represent the requirements of the data system needed to achieve the scientific objectives of the MODIS instruments and science teams. Indeed, the team members have not yet been selected and the team has not yet been formed; however, it has been possible to identify many relevant requirements based on the present concept of EosDIS and through interviews and meetings with key members of the scientific community. These requirements have been grouped by functional component of the data system, and by function within each component. These requirements have been merged with the complete set of Level 1 and Level 2 context diagrams, data flow diagrams, and data dictionary.
- Published
- 1988
9. MODIS Information, Data, and Control System (MIDACS) system specifications and conceptual design
- Author
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Han, D, Salomonson, V, Ormsby, J, Ardanuy, P, Mckay, A, Hoyt, D, Jaffin, S, Vallette, B, Sharts, B, and Folta, D
- Subjects
Earth Resources And Remote Sensing - Abstract
The MODIS Information, Data, and Control System (MIDACS) Specifications and Conceptual Design Document discusses system level requirements, the overall operating environment in which requirements must be met, and a breakdown of MIDACS into component subsystems, which include the Instrument Support Terminal, the Instrument Control Center, the Team Member Computing Facility, the Central Data Handling Facility, and the Data Archive and Distribution System. The specifications include sizing estimates for the processing and storage capacities of each data system element, as well as traffic analyses of data flows between the elements internally, and also externally across the data system interfaces. The specifications for the data system, as well as for the individual planning and scheduling, control and monitoring, data acquisition and processing, calibration and validation, and data archive and distribution components, do not yet fully specify the data system in the complete manner needed to achieve the scientific objectives of the MODIS instruments and science teams. The teams have not yet been formed; however, it was possible to develop the specifications and conceptual design based on the present concept of EosDIS, the Level-1 and Level-2 Functional Requirements Documents, the Operations Concept, and through interviews and meetings with key members of the scientific community.
- Published
- 1988
10. MODIS-HIRIS ground data systems commonality report
- Author
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Han, D, Ramapriyan, H, Salomonson, V, Ormsby, J, Ardanuy, P, Mckay, A, Hoyt, D, Jaffin, S, Vallette, B, and Hurley, E
- Subjects
Earth Resources And Remote Sensing - Abstract
The High Resolution Imaging Spectrometer (HIRIS) and Moderate Resolution Imaging Spectrometer (MODIS) Data Systems Working Group was formed in September 1988 with representatives of the MODIS Data System Study Group and the HIRIS Project Data System Design Group to collaborate in the development of requirements on the EosDIS necessary to meet the science objectives of the two facility instruments. A major objective was to identify and promote commonality between the HIRIS and MODIS data systems, especially from the science users' point of view. A goal was to provide a base set of joint requirements and specifications which could easily be expanded to a Phase-B representation of the needs of the science users of all EOS instruments. This document describes the points of commonality and difference between the Level-II Requirements, Operations Concepts, and Systems Specifications for the ground data systems for the MODIS and HIRIS instruments at their present state of development.
- Published
- 1988
11. Pointed and multi-pointed partitions of type Aand B
- Author
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Chapoton, F. and Vallette, B.
- Abstract
The aim of this paper is to define and study pointed and multi-pointed partition posets of type Aand B(in the classification of Coxeter groups). We compute their characteristic polynomials, incidence Hopf algebras and homology groups. As a corollary, we show that some operads are Koszul over $$\mathbb{Z}$$.
- Published
- 2006
- Full Text
- View/download PDF
12. A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies.
- Author
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Lallemand C, Liang F, Staub F, Simansour M, Vallette B, Huang L, Ferrando-Miguel R, and Tovey MG
- Subjects
- Antigens, CD20 immunology, Cetuximab metabolism, ErbB Receptors immunology, Etanercept metabolism, Genes, Reporter genetics, HEK293 Cells, Humans, Infliximab metabolism, Jurkat Cells, Receptor, ErbB-2 immunology, Receptors, IgG immunology, Rituximab metabolism, Signal Transduction, Transgenes genetics, Trastuzumab metabolism, Tumor Necrosis Factor-alpha immunology, Antibody-Dependent Cell Cytotoxicity, Antigens, CD20 genetics, Crohn Disease immunology, ErbB Receptors genetics, Immunologic Techniques methods, NFATC Transcription Factors genetics, Receptor, ErbB-2 genetics, Receptors, IgG genetics, T-Lymphocytes physiology, Tumor Necrosis Factor-alpha genetics
- Abstract
Novel ADCC effector cells expressing the V-variant or F-variant of Fc γ RIIIa (CD16a) and firefly luciferase under the control of a chimeric promoter incorporating recognition sequences for the principal transcription factors involved in Fc γ RIIIa signal transduction, together with novel target cells overexpressing a constant high level of the specific antigen recognized by rituximab, trastuzumab, cetuximab, infliximab, adalimumab, or etanercept, confer improved sensitivity, specificity, and dynamic range in an ADCC assay relative to effector cells expressing a NFAT-regulated reporter gene and wild-type target cells. The effector cells also contain a normalization gene rendering ADCC assays independent of cell number or serum matrix effects. The novel effector and target cells in a frozen thaw-and-use format exhibit low vial-to-vial and lot-to-lot variation in their performance characteristics reflected by CVs of 10% or less. Homologous control target cells in which the specific target gene has been invalidated by genome editing providing an ideal control and a means of correcting for nonspecific effects were observed with certain samples of human serum. The novel effector cells and target cells expressing noncleavable membrane-bound TNF α have been used to quantify ADCC activity in serum from patients with Crohn's disease treated with infliximab and to relate ADCC activity to drug levels.
- Published
- 2017
- Full Text
- View/download PDF
13. Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
- Author
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El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon S, Papon JF, Lorès P, Yuan L, Collot N, Tissier S, Faucon C, Gacon G, Patrat C, Wolf JP, Dulioust E, Crestani B, Escudier E, Coste A, Legendre M, Touré A, and Amselem S
- Subjects
- Adolescent, Apoptosis Regulatory Proteins, Axoneme genetics, Cilia genetics, Ciliary Motility Disorders pathology, Exome genetics, Female, Flagella genetics, Flagella pathology, HSP40 Heat-Shock Proteins metabolism, Heat-Shock Proteins metabolism, Homozygote, Humans, Infertility, Male pathology, Kartagener Syndrome genetics, Male, Middle Aged, Molecular Chaperones, Mutation, Missense genetics, Phenotype, Polymorphism, Single Nucleotide genetics, Proteasome Endopeptidase Complex metabolism, Protein Stability, RNA Splicing genetics, Semen, Spermatozoa metabolism, Spermatozoa pathology, Ciliary Motility Disorders genetics, Heat-Shock Proteins genetics, Infertility, Male genetics, Mutation
- Abstract
Primary ciliary dyskinesia (PCD) is an autosomal-recessive disease due to functional or ultra-structural defects of motile cilia. Affected individuals display recurrent respiratory-tract infections; most males are infertile as a result of sperm flagellar dysfunction. The great majority of the PCD-associated genes identified so far encode either components of dynein arms (DAs), which are multiprotein-ATPase complexes essential for ciliary motility, or proteins involved in DA assembly. To identify the molecular basis of a PCD phenotype characterized by central complex (CC) defects but normal DA structure, a phenotype found in ∼15% of cases, we performed whole-exome sequencing in a male individual with PCD and unexplained CC defects. This analysis, combined with whole-genome SNP genotyping, identified a homozygous mutation in DNAJB13 (c.833T>G), a gene encoding a HSP40 co-chaperone whose ortholog in the flagellated alga Chlamydomonas localizes to the radial spokes. In vitro studies showed that this missense substitution (p.Met278Arg), which involves a highly conserved residue of several HSP40 family members, leads to protein instability and triggers proteasomal degradation, a result confirmed by the absence of endogenous DNAJB13 in cilia and sperm from this individual. Subsequent DNAJB13 analyses identified another homozygous mutation in a second family; the study of DNAJB13 transcripts obtained from airway cells showed that this mutation (c.68+1G>C) results in a splicing defect consistent with a loss-of-function mutation. Overall, this study, which establishes mutations in DNAJB13 as a cause of PCD, unveils the key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes in humans., (Copyright © 2016 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
14. Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects.
- Author
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Kott E, Legendre M, Copin B, Papon JF, Dastot-Le Moal F, Montantin G, Duquesnoy P, Piterboth W, Amram D, Bassinet L, Beucher J, Beydon N, Deneuville E, Houdouin V, Journel H, Just J, Nathan N, Tamalet A, Collot N, Jeanson L, Le Gouez M, Vallette B, Vojtek AM, Epaud R, Coste A, Clement A, Housset B, Louis B, Escudier E, and Amselem S
- Subjects
- Amino Acid Sequence, Cilia ultrastructure, DNA-Binding Proteins chemistry, Epithelial Cells metabolism, Epithelial Cells pathology, Family, Female, Humans, Male, Microscopy, Video, Molecular Sequence Data, Phenotype, Respiration, Cilia genetics, DNA-Binding Proteins genetics, Genetic Predisposition to Disease, Kartagener Syndrome genetics, Kartagener Syndrome pathology, Mutation genetics
- Abstract
Primary ciliary dyskinesia (PCD) is a rare autosomal-recessive respiratory disorder resulting from defects of motile cilia. Various axonemal ultrastructural phenotypes have been observed, including one with so-called central-complex (CC) defects, whose molecular basis remains unexplained in most cases. To identify genes involved in this phenotype, whose diagnosis can be particularly difficult to establish, we combined homozygosity mapping and whole-exome sequencing in a consanguineous individual with CC defects. This identified a nonsense mutation in RSPH1, a gene whose ortholog in Chlamydomonas reinhardtii encodes a radial-spoke (RS)-head protein and is mainly expressed in respiratory and testis cells. Subsequent analyses of RSPH1 identified biallelic mutations in 10 of 48 independent families affected by CC defects. These mutations include splicing defects, as demonstrated by the study of RSPH1 transcripts obtained from airway cells of affected individuals. Wild-type RSPH1 localizes within cilia of airway cells, but we were unable to detect it in an individual with RSPH1 loss-of-function mutations. High-speed-videomicroscopy analyses revealed the coexistence of different ciliary beating patterns-cilia with a normal beat frequency but abnormal motion alongside immotile cilia or cilia with a slowed beat frequency-in each individual. This study shows that this gene is mutated in 20.8% of individuals with CC defects, whose diagnosis could now be improved by molecular screening. RSPH1 mutations thus appear as a major etiology for this PCD phenotype, which in fact includes RS defects, thereby unveiling the importance of RSPH1 in the proper building of CCs and RSs in humans., (Copyright © 2013 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
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