395 results on '"Van Eyken, P."'
Search Results
2. Translocation of black carbon particles to human intestinal tissueResearch in context
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Thessa Van Pee, Kenneth Vanbrabant, Leen Rasking, Peter Van Eyken, Janneke Hogervorst, Philip Caenepeel, Marcel Ameloot, Michelle Plusquin, and Tim S. Nawrot
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Black carbon ,Ileum ,Colon ,Translocation ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Evidence is accumulating that elevated levels of particulate air pollution, including black carbon, have been linked to gastrointestinal disorders and a lower intestinal bacterial richness and diversity. One of the hypothesized underlying mechanisms is the absorption of air pollution-related particles from the gastrointestinal tract. Methods: We visualized and quantified black carbon particles via white light generation under femtosecond-pulsed laser illumination in ileum and colon biopsies of five human patients. The biodistribution was assessed in three different layers (i.e., mucosa, submucosa, and muscularis propria). Findings: Black carbon particles could be identified in all three tissue layers of the ileum and colon biopsies of five participants (two men and three women; mean ± standard deviation age, 76.40 ± 7.37 years), and their carbonaceous nature was confirmed via emission fingerprinting. The median (±SD) black carbon load was borderline statistically significantly higher in the ileum compared to the colon (1.21 × 105 ± 1.68 × 104 particles/mm3 versus 9.34 × 104 ± 1.33 × 104 particles/mm3; p = 0.07) and was driven by a difference in black carbon load in the submucosa layer (p = 0.01). Regarding the three tissue layers, loads were higher in the submucosa, compared with the mucosa (ileum: +76%, p
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- 2024
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3. High-grade HER2-positive mucoepidermoid carcinoma of the breast: a case report and review of the literature
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Mario Della Mura, Céline Clement, Maria P. Foschini, Sara Vander Borght, Lise Waumans, Peter Van Eyken, Esther Hauben, Machteld Keupers, Caroline Weltens, Ann Smeets, Ines Nevelsteen, and Giuseppe Floris
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Triple-negative breast cancer ,Salivary gland-like tumors of the breast ,Mucoepidermoid carcinoma of the breast ,HER2 ,Case report ,Medicine - Abstract
Abstract Background Mucoepidermoid carcinoma of the breast is a rare special type of salivary gland-like tumor of the breast, usually displaying triple-negative phenotype. To date, only 64 cases have been reported in the English literature. Herein, we report the first case of mucoepidermoid carcinoma of the breast with human epidermal growth factor receptor 2 gene amplification. Case presentation A 58-year-old Caucasian woman treated with breast-conserving surgery, radiotherapy, and chemotherapy for an invasive breast carcinoma of no special type, relapsed 20 years later in the ipsilateral left breast. Histological examination of the core needle biopsy of the relapse deferred to the surgical specimen for the definitive diagnosis, because of the broad differential diagnosis. On the resected specimen we observed the presence of a poorly differentiated carcinoma with mucoepidermoid carcinoma of the breast typical features consisting of epidermoid, intermediate and mucinous cells lacking true keratinization, in keeping with the latest World Health Organization diagnostic criteria. The mucoepidermoid carcinoma of the breast was weakly estrogen receptor and androgen receptor positive and progesterone receptor negative, but exceptionally showed human epidermal growth factor receptor 2 gene amplification. Mastermind-like transcriptional coactivator 2 gene translocations were not detected by fluorescent in situ hybridization. The patient received adjuvant chemotherapy with anti-human epidermal growth factor receptor 2 therapy but no endocrine therapy. After 61 months of follow-up, no signs of local or distant recurrence were observed. Conclusions Mucoepidermoid carcinoma of the breast is a very rare entity. Despite being most frequently triple negative, the standard evaluation of receptor status is mandatory, as well as strict application of World Health Organization diagnostic criteria for correct patient management.
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- 2023
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4. Best Practices for Data Publication in the Astronomical Literature
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Chen, Tracy X., Schmitz, Marion, Mazzarella, Joseph M., Wu, Xiuqin, van Eyken, Julian C., Accomazzi, Alberto, Akeson, Rachel L., Allen, Mark, Beaton, Rachael, Berriman, G. Bruce, Boyle, Andrew W., Brouty, Marianne, Chan, Ben, Christiansen, Jessie L., Ciardi, David R., Cook, David, D'Abrusco, Raffaele, Ebert, Rick, Frayer, Cren, Fulton, Benjamin J., Gelino, Christopher, Helou, George, Henderson, Calen B., Howell, Justin, Kim, Joyce, Landais, Gilles, Lo, Tak, Loup, Cecile, Madore, Barry, Monari, Giacomo, Muench, August, Oberto, Anais, Ocvirk, Pierre, Peek, Joshua E. G., Perret, Emmanuelle, Pevunova, Olga, Ramirez, Solange V., Rebull, Luisa, Shemmer, Ohad, Smale, Alan, Tam, Raymond, Terek, Scott, Van Orsow, Doug, Vannier, Patricia, and Wang, Shin-Ywan
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present an overview of best practices for publishing data in astronomy and astrophysics journals. These recommendations are intended as a reference for authors to help prepare and publish data in a way that will better represent and support science results, enable better data sharing, improve reproducibility, and enhance the reusability of data. Observance of these guidelines will also help to streamline the extraction, preservation, integration and cross-linking of valuable data from astrophysics literature into major astronomical databases, and consequently facilitate new modes of science discovery that will better exploit the vast quantities of panchromatic and multi-dimensional data associated with the literature. We encourage authors, journal editors, referees, and publishers to implement the best practices reviewed here, as well as related recommendations from international astronomical organizations such as the International Astronomical Union (IAU) for publication of nomenclature, data, and metadata. A convenient Checklist of Recommendations for Publishing Data in the Literature is included for authors to consult before the submission of the final version of their journal articles and associated data files. We recommend that publishers of journals in astronomy and astrophysics incorporate a link to this document in their Instructions to Authors., Comment: 19 pages, 1 figure, 3 tables, accepted for publication in ApJS
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- 2021
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5. Artificial Intelligence Models for the Detection of Microsatellite Instability from Whole-Slide Imaging of Colorectal Cancer
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Gavino Faa, Ferdinando Coghe, Andrea Pretta, Massimo Castagnola, Peter Van Eyken, Luca Saba, Mario Scartozzi, and Matteo Fraschini
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whole-slide images ,microsatellite instability ,colorectal cancer ,artificial intelligence ,deep learning ,Medicine (General) ,R5-920 - Abstract
With the advent of whole-slide imaging (WSI), a technology that can digitally scan whole slides in high resolution, pathology is undergoing a digital revolution. Detecting microsatellite instability (MSI) in colorectal cancer is crucial for proper treatment, as it identifies patients responsible for immunotherapy. Even though universal testing for MSI is recommended, particularly in patients affected by colorectal cancer (CRC), many patients remain untested, and they reside mainly in low-income countries. A critical need exists for accessible, low-cost tools to perform MSI pre-screening. Here, the potential predictive role of the most relevant artificial intelligence-driven models in predicting microsatellite instability directly from histology alone is discussed, focusing on CRC. The role of deep learning (DL) models in identifying the MSI status is here analyzed in the most relevant studies reporting the development of algorithms trained to this end. The most important performance and the most relevant deficiencies are discussed for every AI method. The models proposed for algorithm sharing among multiple research and clinical centers, including federal learning (FL) and swarm learning (SL), are reported. According to all the studies reported here, AI models are valuable tools for predicting MSI status on WSI alone in CRC. The use of digitized H&E-stained sections and a trained algorithm allow the extraction of relevant molecular information, such as MSI status, in a short time and at a low cost. The possible advantages related to introducing DL methods in routine surgical pathology are underlined here, and the acceleration of the digital transformation of pathology departments and services is recommended.
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- 2024
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6. Appendiceal Goblet Cell Carcinoma: Role of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
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Gaillard, M., Van Eyken, P., Verswijvel, G., and Van der Speeten, K.
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- 2023
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7. Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in Salmonella Typhimurium
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Daniel Berdejo, Julien Mortier, Alexander Cambré, Malgorzata Sobota, Ronald Van Eyken, Tom Dongmin Kim, Kristof Vanoirbeek, Diego García Gonzalo, Rafael Pagán, Médéric Diard, and Abram Aertsen
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heat resistance ,genetics ,evolution ,virulence ,Salmonella Typhimurium ,Microbiology ,QR1-502 - Abstract
ABSTRACT Understanding the evolutionary dynamics of foodborne pathogens throughout our food production chain is of utmost importance. In this study, we reveal that Salmonella Typhimurium can readily and reproducibly acquire vastly increased heat shock resistance upon repeated exposure to heat shock. Counterintuitively, this boost in heat shock resistance was invariantly acquired through loss-of-function mutations in the dnaJ gene, encoding a heat shock protein that acts as a molecular co-chaperone of DnaK and enables its role in protein folding and disaggregation. As a trade-off, however, the acquisition of heat shock resistance inevitably led to attenuated growth at 37°C and higher temperatures. Interestingly, loss of DnaJ also downregulated the activity of the master virulence regulator HilD, thereby lowering the fraction of virulence-expressing cells within the population and attenuating virulence in mice. By connecting heat shock resistance evolution to attenuation of HilD activity, our results confirm the complex interplay between stress resistance and virulence in Salmonella Typhimurium.IMPORTANCEBacterial pathogens such as Salmonella Typhimurium are equipped with both stress response and virulence features in order to navigate across a variety of complex inhospitable environments that range from food-processing plants up to the gastrointestinal tract of its animal host. In this context, however, it remains obscure whether and how adaptation to one environment would obstruct fitness in another. In this study, we reveal that severe heat stress counterintuitively, but invariantly, led to the selection of S. Typhimurium mutants that are compromised in the activity of the DnaJ heat shock protein. While these mutants obtained massively increased heat resistance, their virulence became greatly attenuated. Our observations, therefore, reveal a delicate balance between optimal tuning of stress response and virulence features in bacterial pathogens.
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- 2024
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8. High-grade HER2-positive mucoepidermoid carcinoma of the breast: a case report and review of the literature
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Mura, Mario Della, Clement, Céline, Foschini, Maria P., Vander Borght, Sara, Waumans, Lise, Van Eyken, Peter, Hauben, Esther, Keupers, Machteld, Weltens, Caroline, Smeets, Ann, Nevelsteen, Ines, and Floris, Giuseppe
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- 2023
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9. Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis
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Mortier, Julien, Govers, Sander K., Cambré, Alexander, Van Eyken, Ronald, Verheul, Jolanda, den Blaauwen, Tanneke, and Aertsen, Abram
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- 2023
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10. Impact of SEM acquisition parameters on the porosity analysis of irradiated U-Mo fuel
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D. Salvato, C.A. Smith, B. Ye, Z.-G. Mei, A.M. Yacout, J. Van Eyken, B.D. Miller, D.D. Keiser, I.Y. Glagolenko, J.J. Giglio, A.B. Robinson, A. Leenaers, J. Wight, and J.L. Henley
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U-Mo fuel ,Fission gas bubbles ,Porosity analysis ,Scanning electron microscopy ,Image analysis ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
In this study, the effect of various scanning electron microscope (SEM) imaging parameters, including voltage, beam current, and magnification, on the porosity analysis of U-Mo fuel was investigated by varying one parameter at a time during back-scattered electron (BSE) micrograph acquisition. Among the parameters assessed, porosity analysis is most sensitive to the SEM voltage. In the range from 5 kV to 30 kV, we reported relative differences as high as 30%, 10%, and 20% in the total porosity, average diameter, and pore density, respectively. Monte Carlo simulations were also performed to determine the influence of SEM voltage on the probing depths of back-scattered electrons. Increasing the voltage from 5 kV to 30 kV resulted in a change in probing depth from few tens of nanometers to several hundreds of nanometers. Portions of pores or entire pores residing below the polished plane that could not be seen at low voltages, and should not be counted for in the estimation of the open porosity, became visible at high voltages. Interestingly, in addition to allowing for a better estimation of the open porosity, the higher sensitivity to surface features at low voltages seems to reduce the number of pixels with intermediate gray levels in the final BSE image. This, in turn, could limit the ground for different interpretation by different analysts, and, as such, has the potential to facilitate a more consistent and uniform porosity analysis across different research laboratories.
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- 2023
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11. DARKNESS: A Microwave Kinetic Inductance Detector Integral Field Spectrograph for High-Contrast Astronomy
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Meeker, Seth R., Mazin, Benjamin A., Walter, Alex B., Strader, Paschal, Fruitwala, Neelay, Bockstiegel, Clint, Szypryt, Paul, Ulbricht, Gerhard, Coiffard, Gregoire, Bumble, Bruce, Cancelo, Gustavo, Zmuda, Ted, Treptow, Ken, Wilcer, Neal, Collura, Giulia, Dodkins, Rupert, Lipartito, Isabel, Zobrist, Nicholas, Bottom, Michael, Shelton, J. Chris, Mawet, Dimitri, van Eyken, Julian C., Vasisht, Gautam, and Serabyn, Eugene
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We present DARKNESS (the DARK-speckle Near-infrared Energy-resolving Superconducting Spectrophotometer), the first of several planned integral field spectrographs to use optical/near-infrared Microwave Kinetic Inductance Detectors (MKIDs) for high-contrast imaging. The photon counting and simultaneous low-resolution spectroscopy provided by MKIDs will enable real-time speckle control techniques and post-processing speckle suppression at framerates capable of resolving the atmospheric speckles that currently limit high-contrast imaging from the ground. DARKNESS is now operational behind the PALM-3000 extreme adaptive optics system and the Stellar Double Coronagraph at Palomar Observatory. Here we describe the motivation, design, and characterization of the instrument, early on-sky results, and future prospects., Comment: 17 pages, 17 figures. PASP Published
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- 2018
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12. More Rapidly Rotating PMS M Dwarfs with Light Curves Suggestive of Orbiting Clouds of Material
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Stauffer, John, Rebull, Luisa, David, Trevor, Jardine, Moira, Cameron, Andrew Collier, Cody, Ann Marie, Hillenbrand, Lynne, Barrado, David, van Eyken, Julian, Melis, Carl, and Briceno, Cesar
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Astrophysics - Solar and Stellar Astrophysics - Abstract
In a previous paper, using data from K2 Campaign 2, we identified 11 very low mass members of the $\rho$ Oph and Upper Scorpius star-forming region as having periodic photometric variability and phased light curves showing multiple scallops or undulations. All the stars with the "scallop-shell" light curve morphology are mid-to-late M dwarfs without evidence of active accretion, and with photometric periods generally $<$1 day. Their phased light curves have too much structure to be attributed to non-axisymmetrically distributed photospheric spots and rotational modulation. We have now identified an additional eight probable members of the same star-forming region plus three stars in the Taurus star-forming region with this same light curve morphology and sharing the same period and spectral type range as the previous group. We describe the light curves of these new stars in detail and present their general physical characteristics. We also examine the properties of the overall set of stars in order to identify common features that might help elucidate the causes of their photometric variability., Comment: Accepted by AJ; 22 pages, 15 figures
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- 2017
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13. The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
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Fanni, Daniela, Gerosa, C., Nurchi, V. M., Manchia, M., Saba, L., Coghe, F., Crisponi, G., Gibo, Y., Van Eyken, P., Fanos, V., and Faa, G.
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- 2021
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14. Very Low-Mass Stellar and Substellar Companions to Solar-like Stars From MARVELS VI: A Giant Planet and a Brown Dwarf Candidate in a Close Binary System HD 87646
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Ma, Bo, Ge, Jian, Wolszczan, Alex, Muterspaugh, Matthew W., Lee, Brian, Henry, Gregory W., Schneider, Donald P., Martin, Eduardo L., Niedzielski, Andrzej, Xie, Jiwei, Fleming, Scott W., Thomas, Neil, Williamson, Michael, Zhu, Zhaohuan, Agol, Eric, Bizyaev, Dmitry, da Costa, Luiz Nicolaci, Jiang, Peng, Fiorenzano, A. F. Martinez, Hernandez, Jonay I. Gonzalez, Guo, Pengcheng, Grieves, Nolan, Li, Rui, Liu, Jane, Mahadevan, Suvrath, Mazeh, Tsevi, Nguyen, Duy Cuong, Paegert, Martin, Sithajan, Sirinrat, Stassun, Keivan, Thirupathi, Sivarani, van Eyken, Julian C., Wan, Xiaoke, Wang, Ji, Wisniewski, John P., Zhao, Bo, and Zucker, Shay
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report the detections of a giant planet (MARVELS-7b) and a brown dwarf candidate (MARVELS-7c) around the primary star in the close binary system, HD 87646. It is the first close binary system with more than one substellar circum-primary companion discovered to the best of our knowledge. The detection of this giant planet was accomplished using the first multi-object Doppler instrument (KeckET) at the Sloan Digital Sky Survey (SDSS) telescope. Subsequent radial velocity observations using ET at Kitt Peak National Observatory, HRS at HET, the "Classic" spectrograph at the Automatic Spectroscopic Telescope at Fairborn Observatory, and MARVELS from SDSS-III confirmed this giant planet discovery and revealed the existence of a long-period brown dwarf in this binary. HD 87646 is a close binary with a separation of $\sim22$ AU between the two stars, estimated using the Hipparcos catalogue and our newly acquired AO image from PALAO on the 200-inch Hale Telescope at Palomar. The primary star in the binary, HD 87646A, has Teff = 5770$\pm$80K, log(g)=4.1$\pm$0.1 and [Fe/H] = $-0.17\pm0.08$. The derived minimum masses of the two substellar companions of HD 87646A are 12.4$\pm$0.7M$_{\rm Jup}$ and 57.0$\pm3.7$M$_{\rm Jup}$. The periods are 13.481$\pm$0.001 days and 674$\pm$4 days and the measured eccentricities are 0.05$\pm$0.02 and 0.50$\pm$0.02 respectively. Our dynamical simulations show the system is stable if the binary orbit has a large semi-major axis and a low eccentricity, which can be verified with future astrometry observations., Comment: Accepted for publication at AJ. RV data are provided as ascii file in the source files
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- 2016
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15. H-alpha Variability in PTFO8-8695 and the Possible Direct Detection of Emission from a 2 Million Year Old Evaporating Hot Jupiter
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Johns-Krull, Christopher M., Prato, Lisa, McLane, Jacob N., Ciardi, David R., van Eyken, Julian C., Chen, Wei, Stauffer, John R., Beichman, Charles A., Frazier, Sarah A., Boden, Andrew F., Morales-Calderon, Maria, and Rebull, Luisa M.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We use high time cadence, high spectral resolution optical observations to detect excess H-alpha emission from the 2 - 3 Myr old weak lined T Tauri star PTFO8-8695. This excess emission appears to move in velocity as expected if it were produced by the suspected planetary companion to this young star. The excess emission is not always present, but when it is, the predicted velocity motion is often observed. We have considered the possibility that the observed excess emission is produced by stellar activity (flares), accretion from a disk, or a planetary companion; we find the planetary companion to be the most likely explanation. If this is the case, the strength of the H-alpha line indicates that the emission comes from an extended volume around the planet, likely fed by mass loss from the planet which is expected to be overflowing its Roche lobe., Comment: 41 pages, 10 figures, accepted by The Astrophysical Journal
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- 2016
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16. Application of the Trend Filtering Algorithm for Photometric Time Series Data
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Gopalan, Giri, Plavchan, Peter, van Eyken, Julian, Ciardi, David, von Braun, Kaspar, and Kane, Stephen R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Detecting transient light curves (e.g., transiting planets) requires high precision data, and thus it is important to effectively filter systematic trends affecting ground based wide field surveys. We apply an implementation of the Trend Filtering Algorithm (TFA) (Kovacs et al. 2005) to the 2MASS calibration catalog and select Palomar Transient Factory (PTF) photometric time series data. TFA is successful at reducing the overall dispersion of light curves, however it may over filter intrinsic variables and increase "instantaneous" dispersion when a template set is not judiciously chosen. In an attempt to rectify these issues we modify the original literature TFA by including measurement uncertainties in its computation, including ancillary data correlated with noise, and algorithmically selecting a template set using clustering algorithms as suggested by various authors. This approach may be particularly useful for appropriately accounting for variable photometric precision surveys and/or combined data-sets. In summary, our contributions are to provide a MATLAB software implementation of TFA and a number of modifications tested on synthetics and real data, summarize the performance of TFA and various modifications on real ground based data sets (2MASS and PTF), and assess the efficacy of TFA and modifications using synthetic light curve tests consisting of transiting and sinusoidal variables. While the transiting variables test indicates that these modifications confer no advantage to transit detection, the sinusoidal variables test indicates potential improvements in detection accuracy., Comment: Accepted by PASP
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- 2016
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17. Search for Optical Pulsations in PSR J0337+1715
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Strader, M. J., Archibald, A. M., Meeker, S. R., Szypryt, P., Walter, A. B., van Eyken, J. C., Ulbricht, G., Stoughton, C., Bumble, B., Kaplan, D. L., and Mazin, B. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on a search for optical pulsations from PSR J0337+1715 at its observed radio pulse period. PSR J0337+1715 is a millisecond pulsar (2.7 ms spin period) in a triple hierarchical system with two white dwarfs, and has a known optical counterpart with g-band magnitude 18. The observations were done with the Array Camera for Optical to Near-IR Spectrophotometry (ARCONS) at the 200" Hale telescope at Palomar Observatory. No significant pulsations were found in the range 4000-11000 angstroms, and we can limit pulsed emission in g-band to be fainter than 25 mag., Comment: 4 pages, 2 figures, accepted to MNRAS
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- 2016
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18. The ARCONS Pipeline: Data Reduction for MKID Arrays
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van Eyken, J. C., Strader, M. J., Walter, A. B., Meeker, S. R., Szypryt, P., Stoughton, C., O'Brien, K., Marsden, D., Rice, N. K., Lin, Y., and Mazin, B. A.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Array Camera for Optical to Near-IR Spectrophotometry, or ARCONS, is a camera based on Microwave Kinetic Inductance Detectors (MKIDs), a new technology that has the potential for broad application in astronomy. Using an array of MKIDs, the instrument is able to produce time-resolved imaging and low-resolution spectroscopy constructed from detections of individual photons. The arrival time and energy of each photon are recorded in a manner similar to X-ray calorimetry, but at higher photon fluxes. The technique works over a very large wavelength range, is free from fundamental read noise and dark-current limitations, and provides microsecond-level timing resolution. Since the instrument reads out all pixels continuously while exposing, there is no loss of active exposure time to readout. The technology requires a different approach to data reduction compared to conventional CCDs. We outline here the prototype data reduction pipeline developed for ARCONS, though many of the principles are also more broadly applicable to energy-resolved photon counting arrays (e.g., transition edge sensors, superconducting tunnel junctions). We describe the pipeline's current status, and the algorithms and techniques employed in taking data from the arrival of photons at the MKID array to the production of images, spectra, and time-resolved light curves., Comment: 16 pages, 19 figures, pdflatex, accepted for ApJS
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- 2015
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19. Follow-Up Observations of PTFO 8-8695: A 3 MYr Old T-Tauri Star Hosting a Jupiter-mass Planetary Candidate
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Ciardi, David R., van Eyken, J. C., Barnes, J. W., Beichman, C. A., Carey, S. J., Crockett, C. J., Eastman, J., Johns-Krull, C. M., Howell, S. B., Kane, S. R., Mclane, J. N., Plavchan, P., Prato, L., Stauffer, J., van Belle, G. T., and von Braun, K.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present Spitzer 4.5\micron\ light curve observations, Keck NIRSPEC radial velocity observations, and LCOGT optical light curve observations of PTFO~8-8695, which may host a Jupiter-sized planet in a very short orbital period (0.45 days). Previous work by \citet{vaneyken12} and \citet{barnes13} predicts that the stellar rotation axis and the planetary orbital plane should precess with a period of $300 - 600$ days. As a consequence, the observed transits should change shape and depth, disappear, and reappear with the precession. Our observations indicate the long-term presence of the transit events ($>3$ years), and that the transits indeed do change depth, disappear and reappear. The Spitzer observations and the NIRSPEC radial velocity observations (with contemporaneous LCOGT optical light curve data) are consistent with the predicted transit times and depths for the $M_\star = 0.34\ M_\odot$ precession model and demonstrate the disappearance of the transits. An LCOGT optical light curve shows that the transits do reappear approximately 1 year later. The observed transits occur at the times predicted by a straight-forward propagation of the transit ephemeris. The precession model correctly predicts the depth and time of the Spitzer transit and the lack of a transit at the time of the NIRSPEC radial velocity observations. However, the precession model predicts the return of the transits approximately 1 month later than observed by LCOGT. Overall, the data are suggestive that the planetary interpretation of the observed transit events may indeed be correct, but the precession model and data are currently insufficient to confirm firmly the planetary status of PTFO~8-8695b., Comment: Accepted for publication in The Astrophysical Journal
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- 2015
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20. IPAC Image Processing and Data Archiving for the Palomar Transient Factory
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Laher, Russ R., Surace, Jason, Grillmair, Carl J., Ofek, Eran O., Levitan, David, Sesar, Branimir, van Eyken, Julian C., Law, Nicholas M., Helou, George, Hamam, Nouhad, Masci, Frank J., Mattingly, Sean, Jackson, Ed, Hacopeans, Eugean, Mi, Wei, Groom, Steve, Teplitz, Harry, Desai, Vandana, Hale, David, Smith, Roger, Walters, Richard, Quimby, Robert, Kasliwal, Mansi, Horesh, Assaf, Bellm, Eric, Barlow, Tom, Waszczak, Adam, Prince, Thomas A., and Kulkarni, Shrinivas R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Palomar Transient Factory (PTF) is a multi-epochal robotic survey of the northern sky that acquires data for the scientific study of transient and variable astrophysical phenomena. The camera and telescope provide for wide-field imaging in optical bands. In the five years of operation since first light on December 13, 2008, images taken with Mould-R and SDSS-g' camera filters have been routinely acquired on a nightly basis (weather permitting), and two different H-alpha filters were installed in May 2011 (656 nm and 663 nm). The PTF image-processing and data-archival program at the Infrared Processing and Analysis Center (IPAC) is tailored to receive and reduce the data, and, from it, generate and preserve astrometrically and photometrically calibrated images, extracted source catalogs, and coadded reference images. Relational databases have been deployed to track these products in operations and the data archive. The fully automated system has benefited by lessons learned from past IPAC projects and comprises advantageous features that are potentially incorporable into other ground-based observatories. Both off-the-shelf and in-house software have been utilized for economy and rapid development. The PTF data archive is curated by the NASA/IPAC Infrared Science Archive (IRSA). A state-of-the-art custom web interface has been deployed for downloading the raw images, processed images, and source catalogs from IRSA. Access to PTF data products is currently limited to an initial public data release (M81, M44, M42, SDSS Stripe 82, and the Kepler Survey Field). It is the intent of the PTF collaboration to release the full PTF data archive when sufficient funding becomes available., Comment: 54 pages, 9 figures, 26 tables; accepted by PASP
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- 2014
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21. Direct Detection of SDSS J0926+3624 Orbital Expansion with ARCONS
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Szypryt, P., Duggan, G. E., Mazin, B. A., Meeker, S. R., Strader, M. J., van Eyken, J. C., Marsden, D., O'Brien, K., Walter, A. B., Ulbricht, G., Prince, T. A., Stoughton, C., and Bumble, B.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
AM Canum Venaticorum (AM CVn) stars belong to a class of ultra-compact, short period binaries with spectra dominated largely by helium. SDSS J0926+3624 is of particular interest as it is the first observed eclipsing AM CVn system. We observed SDSS J0926+3624 with the \textbf{Ar}ray \textbf{C}amera for \textbf{O}ptical to \textbf{N}ear-IR \textbf{S}pectrophotometry (ARCONS) at the Palomar 200" telescope. ARCONS uses a relatively new type of energy-resolved photon counters called Microwave Kinetic Inductance Detectors (MKIDs). ARCONS, sensitive to radiation from 350 to 1100 nm, has a time resolution of several microseconds and can measure the energy of a photon to $\sim10%$. We present the light curves for these observations and examine changes in orbital period from prior observations. Using a quadratic ephemeris model, we measure a period rate of change $\dot{P} = (3.07 \pm 0.56)\times 10^{-13}$. In addition, we use the high timing resolution of ARCONS to examine the system's high frequency variations and search for possible quasi-periodic oscillations (QPOs). Finally, we use the instrument's spectral resolution to examine the light curves in various wavelength bands. We do not find any high frequency QPOs or significant spectral variability throughout an eclipse., Comment: 8 pages, 7 figures, submitted to MNRAS
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- 2013
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22. Excess Optical Enhancement Observed with ARCONS for Early Crab Giant Pulses
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Strader, M. J., Johnson, M. D., Mazin, B. A., Jaeger, G. V. Spiro, Gwinn, C. R., Meeker, S. R., Szypryt, P., van Eyken, J. C., Marsden, D., O'Brien, K., Walter, A. B., Ulbricht, G., Stoughton, C., and Bumble, B.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We observe an extraordinary link in the Crab pulsar between the enhancement of an optical pulse and the timing of the corresponding giant radio pulse. At optical through infrared wavelengths, our observations use the high time resolution of ARCONS, a unique superconducting energy-resolving photon-counting array at the Palomar 200-inch telescope. At radio wavelengths, we observe with the Robert C. Byrd Green Bank Telescope and the GUPPI backend. We see an $11.3\pm2.5\%$ increase in peak optical flux for pulses that have an accompanying giant radio pulse arriving near the peak of the optical main pulse, in contrast to a $3.2\pm0.5\%$ increase when an accompanying giant radio pulse arrives soon after the optical peak. We also observe that the peak of the optical main pulse is $2.8\pm0.8\%$ enhanced when there is a giant radio pulse accompanying the optical interpulse. We observe no statistically significant spectral differences between optical pulses accompanied by and not accompanied by giant radio pulses. Our results extend previous observations of optical-radio correlation to the time and spectral domains. Our refined temporal correlation suggests that optical and radio emission are indeed causally linked, and the lack of spectral differences suggests that the same mechanism is responsible for all optical emission., Comment: 5 pages, 5 figures. Updated to match revised version, accepted to ApJL Nov 7, 2013. Several additions and improved DM in timing solution
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- 2013
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23. Measurement of Spin-Orbit Misalignment and Nodal Precession for the Planet around Pre-Main-Sequence Star PTFO 8-8695 From Gravity Darkening
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Barnes, Jason W., van Eyken, Julian C., Jackson, Brian K., Ciardi, David R., and Fortney, Jonathan J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
PTFO 8-8695b represents the first transiting exoplanet candidate orbiting a pre-main-sequence star. We find that the unusual lightcurve shapes of PTFO 8-8695 can be explained by transits of a planet across an oblate, gravity-darkened stellar disk. We simultaneously and self-consistently fit two separate lightcurves observed in 2009 December and 2010 December. Our two self-consistent fits yield M_p = 3.0 M_Jup and M_p = 3.6 M_Jup for assumed stellar masses of M_* = 0.34 M_Sun and M_* = 0.44 M_Sun respectively. The two fits have precession periods of 293 days and 581 days. These mass determinations (consistent with previous upper limits) along with the strength of the gravity-darkened precessing model together validate PTFO 8-8695b as just the second Hot Jupiter known to orbit an M-dwarf. Our fits show a high degree of spin-orbit misalignment in the PTFO 8-8695 system: 69 +/- 2 or 73.1 +/- 0.5 degrees, in the two cases. The large misalignment is consistent with the hypothesis that planets become Hot Jupiters with random orbital plane alignments early in a system's lifetime. We predict that as a result of the highly misaligned, precessing system, the transits should disappear for months at a time over the course of the system's precession period. The precessing, gravity-darkened model also predicts other observable effects: changing orbit inclination that could be detected by radial velocity observations, changing stellar inclination that would manifest as varying v sin i, changing projected spin-orbit alignment that could be seen by the Rossiter-McLaughlin effect, changing transit shapes over the course of the precession, and differing lightcurves as a function of wavelength. Our measured planet radii of 1.64 R_Jup and 1.68 R_Jup in each case are consistent with a young, hydrogen-dominated planet that results from a hot-start formation mechanism., Comment: Accepted at ApJ
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- 2013
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24. Very Low Mass Stellar and Substellar Companions to Solar-like Stars From MARVELS IV: A Candidate Brown Dwarf or Low-Mass Stellar Companion to HIP 67526
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Jiang, Peng, Ge, Jian, Cargile, Phillip, Crepp, Justin R., De Lee, Nathan, de Mello, Gustavo F. Porto, Esposito, Massimiliano, Ferreira, Letícia D., Femenia, Bruno, Fleming, Scott W., Gaudi, B. Scott, Ghezzi, Luan, Hernández, Jonay I. González, Hebb, Leslie, Lee, Brian L., Ma, Bo, Stassun, Keivan G., Wang, Ji, Wisniewski, John P., Agol, Eric, Bizyaev, Dmitry, Brewington, Howard, Chang, Liang, da Costa, Luiz Nicolaci, Eastman, Jason D., Ebelke, Garrett, Gary, Bruce, Kane, Stephen R., Li, Rui, Liu, Jian, Mahadevan, Suvrath, Maia, Marcio A. G., Malanushenko, Viktor, Malanushenko, Elena, Muna, Demitri, Nguyen, Duy Cuong, Ogando, Ricardo L. C., Oravetz, Audrey, Oravetz, Daniel, Pan, Kaike, Pepper, Joshua, Paegert, Martin, Prieto, Carlos Allende, Rebolo, Rafael, Santiago, Basilio X., Schneider, Donald P., Bradley, Alaina C. Shelden, Sivarani, Thirupathi, Snedden, Stephanie, van Eyken, J. C., Wan, Xiaoke, Weaver, Benjamin A., and Zhao, Bo
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of a candidate brown dwarf or a very low mass stellar companion (MARVELS-5b) to the star HIP 67526 from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The radial velocity curve for this object contains 31 epochs spread over 2.5 years. Our Keplerian fit using a Markov Chain Monte Carlo approach, reveals that the companion has an orbital period of $90.2695^{+0.0188}_{-0.0187}$ days, an eccentricity of $0.4375 \pm 0.0040$ and a semi-amplitude of $2948.14^{+16.65}_{-16.55}$ m s$^{-1}$. Using additional high-resolution spectroscopy, we find the host star has an effective temperature $T_{\rm{eff}}=6004 \pm 34$ K, a surface gravity $\log g$ [cgs] $=4.55 \pm 0.17$ and a metallicity [Fe/H] $=+0.04 \pm 0.06$. The stellar mass and radius determined through the empirical relationship of Torres et al. (2010), yields 1.10$\pm$0.09 $M_{\sun}$ and 0.92$\pm$0.19 $R_{\sun}$. The minimum mass of MARVELS-5b is $65.0 \pm 2.9 M_{Jup}$, indicating that it is likely to be either a brown dwarf or a very low mass star, thus occupying a relatively sparsely-populated region of the mass function of companions to solar-type stars. The distance to this system is 101$\pm$10 pc from the astrometric measurements of Hipparcos. No stellar tertiary is detected in the high-contrast images taken by either FastCam lucky imaging or Keck adaptive optics imaging, ruling out any star with mass greater than 0.2$M_{\sun}$ at a separation larger than 40 AU., Comment: 35 Pages, 10 Figures, 4 Tables, Accepted for Publication in The Astronomical Journal
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- 2013
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25. ARCONS: A 2024 Pixel Optical through Near-IR Cryogenic Imaging Spectrophotometer
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Mazin, B. A., Meeker, S. R., Strader, M. J., Bumble, B., O'Brien, K., Szypryt, P., Marsden, D., van Eyken, J. C., Duggan, G. E., Ulbricht, G., Stoughton, C., and Johnson, M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the design, construction, and commissioning results of ARCONS, the Array Camera for Optical to Near-IR Spectrophotometry. ARCONS is the first ground-based instrument in the optical through near-IR wavelength range based on Microwave Kinetic Inductance Detectors (MKIDs). MKIDs are revolutionary cryogenic detectors, capable of detecting single photons and measuring their energy without filters or gratings, similar to an X-ray microcalorimeter. MKIDs are nearly ideal, noiseless photon detectors, as they do not suffer from read noise or dark current and have nearly perfect cosmic ray rejection. ARCONS is an Integral Field Spectrograph (IFS) containing a lens-coupled 2024 pixel MKID array yielding a 20"x20" field of view, and has been deployed on the Palomar 200" and Lick 120" telescopes for 24 nights of observing. We present initial results showing that ARCONS and its MKID arrays are now a fully operational and powerful tool for astronomical observations., Comment: 12 pages, 16 figures, submitted to PASP
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- 2013
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26. Oportunidades para o desenvolvimento motor presentes nas residências de escolares de 18 a 36 meses do bairro mais populoso de uma capital do Sudeste brasileiro
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Thuany Medeiros Antunes, Cristiane Sousa Nascimento Baez Garcia, and Elisa Beatriz Braga dell’Orto van Eyken
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Jogos e Brinquedos ,Desenvolvimento Infantil ,Habitação ,Medicine (General) ,R5-920 - Abstract
Introdução: Os aspectos individuais de cada criança, as tarefas que ela realiza e o ambiente no qual ela vive são determinantes para o desenvolvimento motor. Objetivo: Conhecer as oportunidades para o desenvolvimento motor presentes nas residências de crianças entre dezoito e trinta e seis meses de idade do bairro mais populoso de uma capital da região sudeste do Brasil. Material e Métodos: Estudo transversal, observacional e analítico, realizado com responsáveis legais de crianças da educação infantil pública, que responderam ao questionário Affordances in the Home Environment for Motor Development - Self Report (AHEMD – SR) na versão em português. As residências foram classificadas e a análise estatística descritiva e o teste de correlação de Pearson realizados. Resultados: A média de idade das crianças foi de 21,9 meses (DP= 3,6). Das 37 residências avaliadas, 22% tiveram uma classificação baixa para as oportunidades oferecidas, e 78,5% uma classificação média. Os espaços interno e externo das residências, na maioria, foram classificados como bons promotores e muito bons promotores de oportunidades, respectivamente. Em relação aos materiais e brinquedos para o desenvolvimento das motricidades fina e grossa, a maioria das residências não oferecia oportunidades suficientes ou oferecia poucas oportunidades. As correlações do escore total do AHEMD com as variáveis escolaridade do pai, rendimento mensal da família, número de crianças e de quartos no domicílio foram fracas e positivas e com a escolaridade da mãe e a idade das crianças, fracas e negativas. Conclusão: Os espaços internos e externos das residências são adequados, mas os brinquedos não são suficientes para o desenvolvimento das motricidades fina e grossa. O nível socioeconômico das famílias interfere nas oportunidades para o desenvolvimento motor das residências.
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- 2021
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27. Erratum for Mortier and Gayán et al., 'Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness'
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Julien Mortier, Elisa Gayán, Ronald Van Eyken, Oscar Enrique Torres Montaguth, Ladan Khodaparast, Laleh Khodaparast, Bert Houben, Sebastien Carpentier, Frederic Rousseau, Joost Schymkowitz, and Abram Aertsen
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Microbiology ,QR1-502 - Published
- 2021
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28. Very Low-mass Stellar and Substellar Companions to Solar-like Stars from Marvels III: A Short-Period Brown Dwarf Candidate Around An Active G0Iv Subgiant
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Ma, Bo, Ge, Jian, Barnes, Rory, Crepp, Justin R., De Lee, Nathan, Dutra-Ferreira, Leticia, Esposito, Massimiliano, Femenia, Bruno, Fleming, Scott W., Gaudi, B. Scott, Ghezzi, Luan, Hebb, Leslie, Hernandez, Jonay I. Gonzalez, Lee, Brian L., de Mello, G. F. Porto, Stassun, Keivan G., Wang, Ji, Wisniewski, John P., Agol, Eric, Bizyaev, Dmitry, Cargile, Phillip, Chang, Liang, da Costa, Luiz Nicolaci, Eastman, Jason D., Gary, Bruce, Jiang, Peng, Kane, Stephen R., Li, Rui, Liu, Jian, Mahadevan, Suvrath, Maia, Marcio A. G., Muna, Demitri, Nguyen, Duy Cuong, Ogando, Ricardo L. C., Oravetz, Daniel, Pepper, Joshua, Paegert, Martin, Prieto, Carlos Allende, Rebolo, Rafael, Santiago, Basilio X., Schneider, Donald P., Shelden, Alaina, Simmons, Audrey, Sivarani, Thirupathi, van Eyken, J. C., Wan, Xiaoke, Weaver, Benjamin A., and Zhao, Bo
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We present an eccentric, short-period brown dwarf candidate orbiting the active, slightly evolved subgiant star TYC 2087-00255-1, which has effective temperature T_eff = 5903+/-42 K, surface gravity log (g) = 4.07+/-0.16 (cgs), and metallicity [Fe/H] = -0.23+/-0.07. This candidate was discovered using data from the first two years of the Multi-object APO Radial Velocity Exoplanets Large-area Survey (MARVELS), which is part of the third phase of Sloan Digital Sky Survey. From our 38 radial velocity measurements spread over a two-year time baseline, we derive a Keplerian orbital fit with semi-amplitude K=3.571+/-0.041 km/s, period P=9.0090+/-0.0004 days, and eccentricity e=0.226+/-0.011. Adopting a mass of 1.16+/-0.11 Msun for the subgiant host star, we infer that the companion has a minimum mass of 40.0+/-2.5 M_Jup. Assuming an edge-on orbit, the semimajor axis is 0.090+/-0.003 AU. The host star is photometrically variable at the \sim1% level with a period of \sim13.16+/-0.01 days, indicating that the host star spin and companion orbit are not synchronized. Through adaptive optics imaging we also found a point source 643+/-10 mas away from TYC 2087-00255-1, which would have a mass of 0.13 Msun if it is physically associated with TYC 2087-00255-1 and has the same age. Future proper motion observation should be able to resolve if this tertiary object is physically associated with TYC 2087-00255-1 and make TYC 2087-00255-1 a triple body system. Core Ca II H and K line emission indicate that the host is chromospherically active, at a level that is consistent with the inferred spin period and measured v_{rot}*sin i, but unusual for a subgiant of this T_eff. This activity could be explained by ongoing tidal spin-up of the host star by the companion., Comment: 14 pages, 13 figures, accepted by AJ
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- 2012
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29. The PTF Orion Project: a Possible Planet Transiting a T-Tauri Star
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van Eyken, Julian C., Ciardi, David R., von Braun, Kaspar, Kane, Stephen R., Plavchan, Peter, Bender, Chad F., Brown, Timothy M., Crepp, Justin R., Fulton, Benjamin J., Howard, Andrew W., Howell, Steve B., Mahadevan, Suvrath, Marcy, Geoffrey W., Shporer, Avi, Szkody, Paula, Akeson, Rachel L., Beichman, Charles A., Boden, Andrew F., Gelino, Dawn M., Hoard, D. W., Ramírez, Solange V., Rebull, Luisa M., Stauffer, John R., Bloom, Joshua S., Cenko, S. Bradley, Kasliwal, Mansi M., Kulkarni, Shrinivas R., Law, Nicholas M., Nugent, Peter E., Ofek, Eran O., Poznanski, Dovi, Quimby, Robert M., Walters, Richard, Grillmair, Carl J., Laher, Russ, Levitan, David B., Sesar, Branimir, and Surace, Jason A.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report observations of a possible young transiting planet orbiting a previously known weak-lined T-Tauri star in the 7-10 Myr old Orion-OB1a/25-Ori region. The candidate was found as part of the Palomar Transient Factory (PTF) Orion project. It has a photometric transit period of 0.448413 +- 0.000040 days, and appears in both 2009 and 2010 PTF data. Follow-up low-precision radial velocity (RV) observations and adaptive optics imaging suggest that the star is not an eclipsing binary, and that it is unlikely that a background source is blended with the target and mimicking the observed transit. RV observations with the Hobby-Eberly and Keck telescopes yield an RV that has the same period as the photometric event, but is offset in phase from the transit center by approximately -0.22 periods. The amplitude (half range) of the RV variations is 2.4 km/s and is comparable with the expected RV amplitude that stellar spots could induce. The RV curve is likely dominated by stellar spot modulation and provides an upper limit to the projected companion mass of M_p sin i_orb < 4.8 +- 1.2 M_Jup; when combined with the orbital inclination, i orb, of the candidate planet from modeling of the transit light curve, we find an upper limit on the mass of the planetary candidate of M_p < 5.5 +- 1.4 M_Jup. This limit implies that the planet is orbiting close to, if not inside, its Roche limiting orbital radius, so that it may be undergoing active mass loss and evaporation., Comment: Corrected typos, minor clarifications; minor updates/corrections to affiliations and bibliography. 35 pages, 10 figures, 3 tables. Accepted to ApJ
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- 2012
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30. The Palomar Transient Factory photometric catalog 1.0
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Ofek, E. O., Laher, R., Surace, J., Levitan, D., Sesar, B., Horesh, A., Law, N., van Eyken, J. C., Kulkarni, S. R., Prince, T. A., Nugent, P., Sullivan, M., Yaron, O., Pickles, A., Agueros, M., Arcavi, I., Bildsten, L., Bloom, J., Cenko, S. B., Gal-Yam, A., Grillmair, C., Helou, G., Kasliwal, M. M., Poznanski, D., and Quimby, R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We construct a photometrically calibrated catalog of non-variable sources from the Palomar Transient Factory (PTF) observations. The first version of this catalog presented here, the PTF photometric catalog 1.0, contains calibrated R_PTF-filter magnitudes for about 21 million sources brighter than magnitude 19, over an area of about 11233 deg^2. The magnitudes are provided in the PTF photometric system, and the color of a source is required in order to convert these magnitudes into other magnitude systems. We estimate that the magnitudes in this catalog have typical accuracy of about 0.02 mag with respect to magnitudes from the Sloan Digital Sky Survey. The median repeatability of our catalog's magnitudes for stars between 15 and 16 mag, is about 0.01 mag, and it is better than 0.03 mag for 95% of the sources in this magnitude range. The main goal of this catalog is to provide reference magnitudes for photometric calibration of visible light observations. Subsequent versions of this catalog, which will be published incrementally online, will be extended to a larger sky area and will also include g_PTF-filter magnitudes, as well as variability and proper motion information., Comment: 6 pages, 6 figures, PASP in press
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- 2012
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31. The Palomar Transient Factory photometric calibration
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Ofek, E. O., Laher, R., Law, N., Surace, J., Levitan, D., Sesar, B., Horesh, A., Poznanski, D., van Eyken, J. C., Kulkarni, S. R., Nugent, P., Zolkower, J., Walters, R., Sullivan, M., Agueros, M., Bildsten, L., Bloom, J., Cenko, S. B., Gal-Yam, A., Grillmair, C., Helou, G., Kasliwal, M. M., and Quimby, R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Palomar Transient Factory (PTF) provides multiple epoch imaging for a large fraction of the sky. Here we describe the photometric calibration of the PTF data products that relates the PTF magnitudes to other mag systems. The calibration process utilizes SDSS r~16 mag point source objects as photometric standards. During photometric conditions, this allows us to solve for the extinction coefficients and color terms, and to estimate the camera illumination correction. This also enables the calibration of fields that are outside the SDSS footprint. We test the precision and repeatability of the PTF photometric calibration. Given that PTF is observing in a single filter each night, we define a PTF calibrated magnitude system for R-band and g-band. We show that, in this system, 59% (47%) of the photometrically calibrated PTF R-band (g-band) data achieve a photometric precision of 0.02-0.04 mag. Given the objects' color, the PTF magnitude system can be converted to other systems. A night-by-night comparison of the calibrated magnitudes of individual stars observed on multiple nights shows that they are consistent to a level of ~0.02 mag. Most of the data that were taken under non-photometric conditions can be calibrated relative to other epochs of the same sky footprint obtained during photometric conditions. We provide a guide describing the use of the PTF photometric calibration data products, as well as the transformations between the PTF magnitude system and the SDSS and Johnson-Cousins systems. (abridged)., Comment: Accepted to PASP, 10 pages
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- 2011
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32. The Palomar Transient Factory Orion Project: Eclipsing Binaries and Young Stellar Objects
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van Eyken, Julian C., Ciardi, David R., Rebull, Luisa M., Stauffer, John R., Akeson, Rachel L., Beichman, Charles A., Boden, Andrew F., von Braun, Kaspar, Gelino, Dawn M., Hoard, D. W., Howell, Steve B., Kane, Stephen R., Plavchan, Peter, Ramírez, Solange V., Bloom, Joshua S., Cenko, S. Bradley, Kasliwal, Mansi M., Kulkarni, Shrinivas R., Law, Nicholas M., Nugent, Peter E., Ofek, Eran O., Poznanski, Dovi, Quimby, Robert M., Grillmair, Carl J., Laher, Russ, Levitan, David, Mattingly, Sean, and Surace, Jason A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The Palomar Transient Factory (PTF) Orion project is an experiment within the broader PTF survey, a systematic automated exploration of the sky for optical transients. Taking advantage of the wide field of view available using the PTF camera at the Palomar 48" telescope, 40 nights were dedicated in December 2009-January 2010 to perform continuous high-cadence differential photometry on a single field containing the young (7-10Myr) 25 Ori association. The primary motivation for the project is to search for planets around young stars in this region. The unique data set also provides for much ancillary science. In this first paper we describe the survey and data reduction pipeline, and present initial results from an inspection of the most clearly varying stars relating to two of the ancillary science objectives: detection of eclipsing binaries and young stellar objects. We find 82 new eclipsing binary systems, 9 of which we are candidate 25 Ori- or Orion OB1a-association members. Of these, 2 are potential young W UMa type systems. We report on the possible low-mass (M-dwarf primary) eclipsing systems in the sample, which include 6 of the candidate young systems. 45 of the binary systems are close (mainly contact) systems; one shows an orbital period among the shortest known for W UMa binaries, at 0.2156509 \pm 0.0000071d, with flat-bottomed primary eclipses, and a derived distance consistent with membership in the general Orion association. One of the candidate young systems presents an unusual light curve, perhaps representing a semi-detached binary system with an inflated low-mass primary or a star with a warped disk, and may represent an additional young Orion member. Finally, we identify 14 probable new classical T-Tauri stars in our data, along with one previously known (CVSO 35) and one previously reported as a candidate weak-line T-Tauri star (SDSS J052700.12+010136.8)., Comment: 66 pages, 27 figures, accepted to Astronomical Journal. Minor typographical corrections and update to author affiliations
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- 2011
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33. Eclipsing Binary Science Via the Merging of Transit and Doppler Exoplanet Survey Data - A Case Study With the MARVELS Pilot Project and SuperWASP
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Fleming, Scott W., Maxted, Pierre F. L., Hebb, Leslie, Stassun, Keivan G., Ge, Jian, Cargile, Phillip A., Ghezzi, Luan, De Lee, Nathan M., Wisniewski, John, Gary, Bruce, de Mello, Gustavo F. Porto, Ferreira, Leticia, Zhao, Bo, Anderson, David R., Wan, Xiaoke, Hellier, Coel, Guo, Pengcheng, West, Richard G., Mahadevan, Suvrath, Pollacco, Don, Lee, Brian, Cameron, Andrew Collier, van Eyken, Julian C., Skillen, Ian, Crepp, Justin R., Nguyen, Duy Cuong, Kane, Stephen R., Paegert, Martin, da Costa, Luiz Nicolaci, Maia, Marcio A. G., and Santiago, Basilio X.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Exoplanet transit and Doppler surveys discover many binary stars during their operation that can be used to conduct a variety of ancillary science. Specifically, eclipsing binary stars can be used to study the stellar mass-radius relationship and to test predictions of theoretical stellar evolution models. By cross-referencing 24 binary stars found in the MARVELS Pilot Project with SuperWASP photometry, we find two new eclipsing binaries, TYC 0272-00458-1 and TYC 1422-01328-1, which we use as case studies to develop a general approach to eclipsing binaries in survey data. TYC 0272-00458-1 is a single-lined spectroscopic binary for which we calculate a mass of the secondary and radii for both components using reasonable constraints on the primary mass through several different techniques. For a primary mass of M_1 = 0.92 +/- 0.1 M_solar, we find M_2 = 0.610 +/- 0.036 M_solar, R_1 = 0.932 +/- 0.076 R_solar and R_2 = 0.559 +/- 0.102 R_solar, and find that both stars have masses and radii consistent with model predictions. TYC 1422-01328-1 is a triple-component system for which we can directly measure the masses and radii of the eclipsing pair. We find that the eclipsing pair consists of an evolved primary star (M_1 = 1.163 +/- 0.034 M_solar, R_1 = 2.063 +/- 0.058 R_solar) and a G-type dwarf secondary (M_2 = 0.905 +/- 0.067 M_solar, R_2 = 0.887 +/- 0.037 R_solar). We provide the framework necessary to apply this analysis to much larger datasets., Comment: Accepted for publication in AJ
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- 2011
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34. Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness
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Julien Mortier, Elisa Gayán, Ronald Van Eyken, Oscar Enrique Torres Montaguth, Ladan Khodaparast, Laleh Khodaparast, Bert Houben, Sebastien Carpentier, Frederic Rousseau, Joost Schymkowitz, and Abram Aertsen
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evolution ,genetics ,heat resistance ,protein aggregates ,Microbiology ,QR1-502 - Abstract
ABSTRACT Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using the Escherichia coli model system unexpectedly revealed that seemingly random single mutations in its tnaA gene can confer significant heat resistance. Closer examination, however, indicated that these mutations create folding-deficient and aggregation-prone TnaA variants that in turn can endogenously and preemptively trigger HSP expression to cause heat resistance. These findings, importantly, demonstrate that even erosive mutations with disruptive effects on protein structure and functionality can still yield true gain-of-function alleles with a selective advantage in adaptive evolution.
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- 2021
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35. MARVELS-1b: A Short-Period, Brown Dwarf Desert Candidate from the SDSS-III MARVELS Planet Search
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Lee, Brian L., Ge, Jian, Fleming, Scott W., Stassun, Keivan G., Gaudi, B. Scott, Barnes, Rory, Mahadevan, Suvrath, Eastman, Jason D., Wright, Jason, Siverd, Robert J., Gary, Bruce, Ghezzi, Luan, Laws, Chris, Wisniewski, John P., de Mello, G. F. Porto, Ogando, Ricardo L. C., Maia, Marcio A. G., da Costa, Luiz Nicolaci, Sivarani, Thirupathi, Pepper, Joshua, Nguyen, Duy Cuong, Hebb, Leslie, De Lee, Nathan, Wang, Ji, Wan, Xiaoke, Zhao, Bo, Chang, Liang, Groot, John, Varosi, Frank, Hearty, Fred, Hanna, Kevin, van Eyken, J. C., Kane, Stephen R., Agol, Eric, Bizyaev, Dmitry, Bochanski, John J., Brewington, Howard, Chen, Zhiping, Costello, Erin, Dou, Liming, Eisenstein, Daniel J., Fletcher, Adam, Ford, Eric B., Guo, Pengcheng, Holtzman, Jon A., Jiang, Peng, Leger, R. French, Liu, Jian, Long, Daniel C., Malanushenko, Elena, Malanushenko, Viktor, Malik, Mohit, Oravetz, Daniel, Pan, Kaike, Rohan, Pais, Schneider, Donald P., Shelden, Alaina, Snedden, Stephanie A., Simmons, Audrey, Weaver, B. A., Weinberg, David H., and Xie, Ji-Wei
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present a new short-period brown dwarf candidate around the star TYC 1240-00945-1. This candidate was discovered in the first year of the Multi-object APO Radial Velocity Exoplanets Large-area Survey (MARVELS), which is part of the third phase of the Sloan Digital Sky Survey (SDSS-III), and we designate the brown dwarf as MARVELS-1b. MARVELS uses the technique of dispersed fixed-delay interferometery to simultaneously obtain radial velocity measurements for 60 objects per field using a single, custom-built instrument that is fiber fed from the SDSS 2.5-m telescope. From our 20 radial velocity measurements spread over a ~370 d time baseline, we derive a Keplerian orbital fit with semi-amplitude K=2.533+/-0.025 km/s, period P=5.8953+/-0.0004 d, and eccentricity consistent with circular. Independent follow-up radial velocity data confirm the orbit. Adopting a mass of 1.37+/-0.11 M_Sun for the slightly evolved F9 host star, we infer that the companion has a minimum mass of 28.0+/-1.5 M_Jup, a semimajor axis 0.071+/-0.002 AU assuming an edge-on orbit, and is probably tidally synchronized. We find no evidence for coherent instrinsic variability of the host star at the period of the companion at levels greater than a few millimagnitudes. The companion has an a priori transit probability of ~14%. Although we find no evidence for transits, we cannot definitively rule them out for companion radii ~<1 R_Jup., Comment: 47 pages, 11 figures. Accepted for publication in ApJ
- Published
- 2010
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36. Characterizing the Variability of Stars with Early-Release Kepler Data
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Ciardi, David R., von Braun, Kaspar, Bryden, Geoff, van Eyken, Julian, Howell, Steve B., Kane, Stephen R., Plavchan, Peter, Ramirez, Solange V., and Stauffer, John R.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present a variability analysis of the early-release first quarter of data publicly released by the Kepler project. Using the stellar parameters from the Kepler Input Catalog, we have separated the sample into 129,000 dwarfs and 17,000 giants, and further sub-divided the luminosity classes into temperature bins corresponding approximately to the spectral classes A, F, G, K, and M. Utilizing the inherent sampling and time baseline of the public dataset (30 minute sampling and 33.5 day baseline), we have explored the variability of the stellar sample. The overall variability rate of the dwarfs is 25% for the entire sample, but can reach 100% for the brightest groups of stars in the sample. G-dwarfs are found to be the most stable with a dispersion floor of $\sigma \sim 0.04$ mmag. At the precision of Kepler, $>95$% of the giant stars are variable with a noise floor of $\sim 0.1$ mmag, 0.3 mmag, and 10 mmag for the G-giants, K-giants, and M-giants, respectively. The photometric dispersion of the giants is consistent with acoustic variations of the photosphere; the photometrically-derived predicted radial velocity distribution for the K-giants is in agreement with the measured radial velocity distribution. We have also briefly explored the variability fraction as a function of dataset baseline (1 - 33 days), at the native 30-minute sampling of the public Kepler data. To within the limitations of the data, we find that the overall variability fractions increase as the dataset baseline is increased from 1 day to 33 days, in particular for the most variable stars. The lower mass M-dwarf, K-dwarf, G-dwarf stars increase their variability more significantly than the higher mass F-dwarf and A-dwarf stars as the time-baseline is increased, indicating that the variability of the lower mass stars is mostly characterized by timescales of weeks whi...astroph will not allow longer abstract!, Comment: Accepted for publication in The Astronomical Journal; Replaces submitted version
- Published
- 2010
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37. Discovery of a Low-Mass Companion to a Metal-Rich F Star with the MARVELS Pilot Project
- Author
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Fleming, Scott W., Ge, Jian, Mahadevan, Suvrath, Lee, Brian, Eastman, Jason D., Siverd, Robert J., Gaudi, B. Scott, Niedzielski, Andrzej, Sivarani, Thirupathi, Stassun, Keivan, Wolszczan, Alex, Barnes, Rory, Gary, Bruce, Nguyen, Duy Cuong, Morehead, Robert C., Wan, Xiaoke, Zhao, Bo, Liu, Jian, Guo, Pengcheng, Kane, Stephen R., van Eyken, Julian C., De Lee, Nathan M., Crepp, Justin R., Shelden, Alaina C., Laws, Chris, Wisniewski, John P., Schneider, Donald P., Pepper, Joshua, Snedden, Stephanie A., Pan, Kaike, Bizyaev, Dmitry, Brewington, Howard, Malanushenko, Olena, Malanushenko, Viktor, Oravetz, Daniel, Simmons, Audrey, and Watters, Shannon
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of a low-mass companion orbiting the metal-rich, main sequence F star TYC 2949-00557-1 during the MARVELS (Multi-object APO Radial Velocity Exoplanet Large-area Survey) Pilot Project. The host star has an effective temperature T_eff = 6135 +/- 40 K, log(g) = 4.4 +/- 0.1 and [Fe/H] = 0.32 +/- 0.01, indicating a mass of M = 1.25 +/- 0.09 M_\odot and R = 1.15 +/- 0.15 R_\odot. The companion has an orbital period of 5.69449 +/- 0.00023 days and straddles the hydrogen burning limit with a minimum mass of 64 M_J, and may thus be an example of the rare class of brown dwarfs orbiting at distances comparable to those of "Hot Jupiters." We present relative photometry that demonstrates the host star is photometrically stable at the few millimagnitude level on time scales of hours to years, and rules out transits for a companion of radius greater than 0.8 R_J at the 95% confidence level. Tidal analysis of the system suggests that the star and companion are likely in a double synchronous state where both rotational and orbital synchronization have been achieved. This is the first low-mass companion detected with a multi-object, dispersed, fixed-delay interferometer., Comment: 26 pages and 12 figures, accepted for publication in ApJ
- Published
- 2010
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38. Theory of Dispersed Fixed-Delay Interferometry for Radial Velocity Exoplanet Searches
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van Eyken, Julian C., Ge, Jian, and Mahadevan, Suvrath
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The dispersed fixed-delay interferometer (DFDI) represents a new instrument concept for high-precision radial velocity (RV) surveys for extrasolar planets. A combination of Michelson interferometer and medium-resolution spectrograph, it has the potential for performing multi-object surveys, where most previous RV techniques have been limited to observing only one target at a time. Because of the large sample of extrasolar planets needed to better understand planetary formation, evolution, and prevalence, this new technique represents a logical next step in instrumentation for RV extrasolar planet searches, and has been proven with the single-object Exoplanet Tracker (ET) at Kitt Peak National Observatory, and the multi-object W. M. Keck/MARVELS Exoplanet Tracker at Apache Point Observatory. The development of the ET instruments has necessitated fleshing out a detailed understanding of the physical principles of the DFDI technique. Here we summarize the fundamental theoretical material needed to understand the technique and provide an overview of the physics underlying the instrument's working. We also derive some useful analytical formulae that can be used to estimate the level of various sources of error generic to the technique, such as photon shot noise when using a fiducial reference spectrum, contamination by secondary spectra (e.g., crowded sources, spectroscopic binaries, or moonlight contamination), residual interferometer comb, and reference cross-talk error. Following this, we show that the use of a traditional gas absorption fiducial reference with a DFDI can incur significant systematic errors that must be taken into account at the precision levels required to detect extrasolar planets., Comment: 58 pages, 11 figures, 1 table, 3 appendices. Accepted for publication in ApJS. Minor typographical corrections; update to acknowledgments
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- 2010
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39. The Palomar Transient Factory: System Overview, Performance and First Results
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Law, N. M., Kulkarni, S. R., Dekany, R. G., Ofek, E. O., Quimby, R. M., Nugent, P. E., Surace, J., Grillmair, C. C., Bloom, J. S., Kasliwal, M. M., Bildsten, L., Brown, T., Cenko, S. B., Ciardi, D., Croner, E., Djorgovski, S. G., van Eyken, J. C., Filippenko, A. V., Fox, D. B., Gal-Yam, A., Hale, D., Hamam, N., Helou, G., Henning, J. R., Howell, D. A., Jacobsen, J., Laher, R., Mattingly, S., McKenna, D., Pickles, A., Poznanski, D., Rahmer, G., Rau, A., Rosing, W., Shara, M., Smith, R., Starr, D., Sullivan, M., Velur, V., Walters, R. S., and Zolkower, J.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Palomar Transient Factory (PTF) is a fully-automated, wide-field survey aimed at a systematic exploration of the optical transient sky. The transient survey is performed using a new 8.1 square degree camera installed on the 48-inch Samuel Oschin telescope at Palomar Observatory; colors and light curves for detected transients are obtained with the automated Palomar 60-inch telescope. PTF uses eighty percent of the 1.2-m and fifty percent of the 1.5-m telescope time. With an exposure of 60-s the survey reaches a depth of approximately 21.3 in g' and 20.6 in R (5 sigma, median seeing). Four major experiments are planned for the five-year project: 1) a 5-day cadence supernova search; 2) a rapid transient search with cadences between 90 seconds and 1 day; 3) a search for eclipsing binaries and transiting planets in Orion; and 4) a 3-pi sr deep H-alpha survey. PTF provides automatic, realtime transient classification and follow up, as well as a database including every source detected in each frame. This paper summarizes the PTF project, including several months of on-sky performance tests of the new survey camera, the observing plans and the data reduction strategy. We conclude by detailing the first 51 PTF optical transient detections, found in commissioning data., Comment: 12 pages, 11 figures, 3 tables, submitted to PASP
- Published
- 2009
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40. Ambient black carbon particles reach the fetal side of human placenta
- Author
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Hannelore Bové, Eva Bongaerts, Eli Slenders, Esmée M. Bijnens, Nelly D. Saenen, Wilfried Gyselaers, Peter Van Eyken, Michelle Plusquin, Maarten B. J. Roeffaers, Marcel Ameloot, and Tim S. Nawrot
- Subjects
Science - Abstract
Exposure to air pollution during pregnancy has been associated with impaired birth outcomes. Here, Bové et al. report evidence of black carbon particle deposition on the fetal side of human placentae, including at early stages of pregnancy, suggesting air pollution could affect birth outcome through direct effects on the fetus.
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- 2019
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41. An Inexpensive Field-Widened Monolithic Michelson Interferometer for Precision Radial Velocity Measurements
- Author
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Mahadevan, Suvrath, Ge, Jian, Fleming, Scott W., Wan, Xiaoke, DeWitt, Curtis, van Eyken, Julian C., and McDavitt, Dan
- Subjects
Astrophysics - Abstract
We have constructed a thermally compensated field-widened monolithic Michelson interferometer that can be used with a medium-resolution spectrograph to measure precise Doppler radial velocities of stars. Our prototype monolithic fixed-delay interferometer is constructed with off-the-shelf components and assembled using a hydrolysis bonding technique. We installed and tested this interferometer in the Exoplanet Tracker (ET) instrument at the Kitt Peak 2.1m telescope, an instrument built to demonstrate the principles of dispersed fixed delay interferometry. An iodine cell allows the interferometer drift to be accurately calibrated, relaxing the stability requirements on the interferometer itself. When using our monolithic interferometer, the ET instrument has no moving parts (except the iodine cell), greatly simplifying its operation. We demonstrate differential radial velocity precision of a few m s$^{-1}$ on well known radial velocity standards and planet bearing stars when using this interferometer. Such monolithic interferometers will make it possible to build relatively inexpensive instruments that are easy to operate and capable of precision radial velocity measurements. A larger multi-object version of the Exoplanet Tracker will be used to conduct a large scale survey for planetary systems as part of the Sloan Digital Sky Survey III (SDSS III). Variants of the techniques and principles discussed in this paper can be directly applied to build large monolithic interferometers for such applications, enabling the construction of instruments capable of efficiently observing many stars simultaneously at high velocity-precision., Comment: Accepted for publication in PASP
- Published
- 2008
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42. Measuring Stellar Radial Velocities with a Dispersed Fixed-Delay Interferometer
- Author
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Mahadevan, Suvrath, van Eyken, Julian, Ge, Jian, DeWitt, Curtis, Fleming, Scott W., Cohen, Roger, Crepp, Justin, and Heuvel, Andrew Vanden
- Subjects
Astrophysics - Abstract
We demonstrate the ability to measure precise stellar barycentric radial velocities with the dispersed fixed-delay interferometer technique using the Exoplanet Tracker (ET), an instrument primarily designed for precision differential Doppler velocity measurements using this technique. Our barycentric radial velocities, derived from observations taken at the KPNO 2.1 meter telescope, differ from those of Nidever et al. by 0.047 km/s (rms) when simultaneous iodine calibration is used, and by 0.120 km/s (rms) without simultaneous iodine calibration. Our results effectively show that a Michelson interferometer coupled to a spectrograph allows precise measurements of barycentric radial velocities even at a modest spectral resolution of R ~ 5100. A multi-object version of the ET instrument capable of observing ~500 stars per night is being used at the Sloan 2.5 m telescope at Apache Point Observatory for the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS), a wide-field radial velocity survey for extrasolar planets around TYCHO-2 stars in the magnitude range 7.6
- Published
- 2008
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43. The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument
- Author
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Ge, Jian, van Eyken, Julian, Mahadevan, Suvrath, DeWitt, Curtis, Kane, Stephen R., Cohen, Roger, Heuvel, Andrew Vanden, Fleming, Scott W., Guo, Pengcheng, Henry, Gregory W., Schneider, Donald P., Ramsey, Lawrence W., Wittenmyer, Robert A., Endl, Michael, Cochran, William D., Ford, Eric B., Martin, Eduardo L., Israelian, Garik, Valenti, Jeff, and Montes, David
- Subjects
Astrophysics - Abstract
We report the detection of the first extrasolar planet, ET-1 (HD 102195b), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial velocity variability to the star with a semiamplitude of $63.4\pm2.0$ m s$^{-1}$ and a period of 4.11 days. The planetary minimum mass ($m \sin i$) is $0.488\pm0.015$ $M_J$., Comment: 42 pages, 11 figures and 5 tables, Accepted for publication in ApJ
- Published
- 2006
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44. The Capabilities of the EISCAT Svalbard Radar for Inter-hemispheric Coordinated Studies
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Grydeland, Tom, Strømme, Anja, van Eyken, Tony, and La Hoz, Cesar
- Subjects
Physics - Space Physics ,Physics - Instrumentation and Detectors - Abstract
In this article we want to present the EISCAT Svalbard Radar (ESR) in some detail, as well as some of the instruments of interest for ionospheric and magnetospheric research that are located in the vicinity of it. We particularly describe how this instrument cluster, close to the geomagnetic conjugate point of the Chinese Antarctic Zhongshan station, can contribute to inter-hemispheric coordinated studies of the polar Ionosphere., Comment: 12 pages, 3 PostScript figures
- Published
- 2004
45. First Planet Confirmation with a Dispersed Fixed-Delay Interferometer
- Author
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van Eyken, J. C., Ge, J., Mahadevan, S., and DeWitt, C.
- Subjects
Astrophysics - Abstract
The Exoplanet Tracker is a prototype of a new type of fibre-fed instrument for performing high precision relative Doppler measurements to detect extra-solar planets. A combination of Michelson interferometer and medium resolution spectrograph, this low-cost instrument facilitates radial velocity measurements with high throughput over a small bandwidth (~ 300 Angstroms), and has the potential to be designed for multi-object operation with moderate bandwidths (~1000 Angstroms). We present the first planet detection with this new type of instrument, a successful confirmation of the well established planetary companion to 51 Peg, showing an rms precision of 11.5m/s over five days. We also show comparison measurements of the radial velocity stable star, Eta Cas, showing an rms precision of 7.9m/s over seven days. These new results are starting to approach the precision levels obtained with traditional radial velocity techniques based on cross-dispersed echelles. We anticipate that this new technique could have an important impact in the search for extra-solar planets., Comment: 14 pages, 3 figures, 3 tables, AASTeX 5.0; accepted for ApJ Letters. Minor changes, corrections to typos; some acknowledgements added
- Published
- 2003
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46. All Sky Doppler Extrasolar Planet Surveys with a Multi-object Dispersed Fixed-delay Interferometer
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Ge, Jian, Mahadevan, Suvrath, van Eyken, Julian, DeWitt, Curtis, and Shaklan, Stuart
- Subjects
Astrophysics - Abstract
We propose to use a high throughput and high precision multi-object dispersed fixed-delay interferometer for all sky Doppler surveys for extrasolar planets. This instrument, a combination of a fixed-delay interferometer with a moderate resolution spectrometer,is completely different from current echelle spectrometers. Doppler RV is measured through monitoring interference fringe shifts of stellar absorption lines over a broad band. Coupling this multi-object instrument with a wide field telescope (a few degree, such as Sloan and WIYN) and UV, visible and near-IR detectors will allow to simultaneously obtain hundreds of stellar fringing spectra for searching for planets. The RV survey speed can be increased by more than 2 orders of magnitude over that for the echelles. A prototype dispersed fixed-delay interferometer has been observed at the Hobby-Eberly 9m and Palomar 5m telescopes in 2001 and demonstrated photo noise limited Doppler precision with Aldebaran. Our recent observations at the KPNO 2.1m telescope in 2002 demonstrate a short term Doppler precision of ~ 3 m/s with eta Cas (V = 3.5), a RV stable star and also obtained a RV curve for 51 Peg. (V = 5.5), confirming previous planet detection with an independent RV technique. The total measured detection efficiency including the sky, telescope and fiber transmission losses, the instrument and iodine transmission losses and detector quantum efficiency is 3.4% under 1.5 arcsec seeing conditions, which is comparable to all of the echelle spectrometers for planet detection., Comment: 8 pages, 4 figures, to be published in the Scientif Frontiers in Research on Extrasolar Planets, ASP Conf. Proceedings, eds. Deming & Seager
- Published
- 2002
47. Autoimmune liver disease triggered by SARS-CoV-2: a case report and review of the literature.
- Author
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FANNI, D., GEROSA, C., SERRA, G., MIGLIANTI, M., COGHE, F., VAN EYKEN, P., FAA, G., LA NASA, G., and GUIDO, M.
- Abstract
BACKGROUND: An increasing number of coronavirus disease 2019 (COVID-19) related autoimmune hepatitis (AIH) and autoimmune liver disease (AILD) has been already described so far in the last three years. This rise has set up some diagnostic and therapeutic concerns, although steroid therapy has mostly been efficient, avoiding main significant side effects. CASE PRESENTATION: We report the case of a 52-year-old subject displaying liver function impairment at the laboratory tests while positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) swab. Needle liver biopsy showed severe portal inflammation, interface hepatitis, lobular inflammation, abundant plasma cells, bridging necrosis, endothelialitis, bile duct vanishing disease, and ductular reaction. The diagnosis of autoimmune liver disease (AILD) was performed. After a month of steroid and ursodeoxycholic acid medications, liver function fully recovered. Azathioprine was introduced, and steroids were gradually reduced. CONCLUSIONS: Probably triggered by the SARS-CoV-2-induced cytokine storm, the association between COVID-19 and autoimmune-related inflammatory injury may display a particular paradigm of AILD pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
48. Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury
- Author
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Pierpaolo Coni, Giuseppina Pichiri, Joanna Izabela Lachowicz, Alberto Ravarino, Francesca Ledda, Daniela Fanni, Clara Gerosa, Monica Piras, Ferdinando Coghe, Yukio Gibo, Flaviana Cau, Massimo Castagnola, Peter Van Eyken, Luca Saba, Marco Piludu, and Gavino Faa
- Subjects
zinc ,COVID-19 ,Wilson’s disease ,non-alcoholic liver disease ,drug therapy ,Organic chemistry ,QD241-441 - Abstract
Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete with copper for their absorption in the gastrointestinal tract let to introduce zinc in the therapy of Wilson’s disease, a congenital disorder of copper metabolism characterized by a systemic copper storage. Nowadays, zinc salts are considered one of the best therapeutic approach in patients affected by Wilson’s disease. On the basis of the similarities, at histological level, between Wilson’s disease and non-alcoholic liver disease, zinc has been successfully introduced in the therapy of non-alcoholic liver disease, with positive effects both on insulin resistance and oxidative stress. Recently, zinc deficiency has been indicated as a possible factor responsible for the susceptibility of elderly patients to undergo infection by SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic. Here, we present the data correlating zinc deficiency with the insurgence and progression of Covid-19 with low zinc levels associated with severe disease states. Finally, the relevance of zinc supplementation in aged people at risk for SARS-CoV-2 is underlined, with the aim that the zinc-based drug, classically used in the treatment of copper overload, might be recorded as one of the tools reducing the mortality of COVID-19, particularly in elderly people.
- Published
- 2021
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49. Ambient black carbon particles reach the fetal side of human placenta
- Author
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Bové, Hannelore, Bongaerts, Eva, Slenders, Eli, Bijnens, Esmée M., Saenen, Nelly D., Gyselaers, Wilfried, Van Eyken, Peter, Plusquin, Michelle, Roeffaers, Maarten B. J., Ameloot, Marcel, and Nawrot, Tim S.
- Published
- 2019
- Full Text
- View/download PDF
50. Low vascularization of the nephrogenic zone of the fetal kidney suggests a major role for hypoxia in human nephrogenesis
- Author
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Gerosa, C., Fanni, D., Faa, A., Van Eyken, P., Ravarino, A., Fanos, V., and Faa, G.
- Published
- 2017
- Full Text
- View/download PDF
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