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3. Predictors and outcomes of heart failure with mid‐range ejection fraction

Author

Bhambhani, Vijeta, Kizer, Jorge R, Lima, Joao AC, van der Harst, Pim, Bahrami, Hossein, Nayor, Matthew, de Filippi, Christopher R, Enserro, Danielle, Blaha, Michael J, Cushman, Mary, Wang, Thomas J, Gansevoort, Ron T, Fox, Caroline S, Gaggin, Hanna K, Kop, Willem J, Liu, Kiang, Vasan, Ramachandran S, Psaty, Bruce M, Lee, Douglas S, Brouwers, Frank P, Hillege, Hans L, Bartz, Traci M, Benjamin, Emelia J, Chan, Cheeling, Allison, Matthew, Gardin, Julius M, Januzzi, James L, Levy, Daniel, Herrington, David M, van Gilst, Wiek H, Bertoni, Alain G, Larson, Martin G, de Boer, Rudolf A, Gottdiener, John S, Shah, Sanjiv J, and Ho, Jennifer E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Cardiovascular, Clinical Research, Heart Disease, Good Health and Well Being, Aged, Cause of Death, Echocardiography, Female, Follow-Up Studies, Heart Failure, Heart Ventricles, Humans, Incidence, Male, Middle Aged, Prognosis, Prospective Studies, Risk Assessment, Stroke Volume, Survival Rate, United States, Heart failure, Risk factor, Ejection fraction, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

AimsWhile heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid-range ejection fraction (HFmrEF) remain unclear. We sought to examine clinical and biochemical predictors of incident HFmrEF in the community.Methods and resultsWe pooled data from four community-based longitudinal cohorts, with ascertainment of new heart failure (HF) classified into HFmrEF [ejection fraction (EF) 41-49%], HFpEF (EF ≥50%), and HFrEF (EF ≤40%). Predictors of incident HF subtypes were assessed using multivariable Cox models. Among 28 820 participants free of HF followed for a median of 12 years, there were 200 new HFmrEF cases, compared with 811 HFpEF and 1048 HFrEF. Clinical predictors of HFmrEF included age, male sex, systolic blood pressure, diabetes mellitus, and prior myocardial infarction (multivariable adjusted P ≤ 0.003 for all). Biomarkers that predicted HFmrEF included natriuretic peptides, cystatin-C, and high-sensitivity troponin (P ≤ 0.0004 for all). Natriuretic peptides were stronger predictors of HFrEF [hazard ratio (HR) 2.00 per 1 standard deviation increase, 95% confidence interval (CI) 1.81-2.20] than of HFmrEF (HR 1.51, 95% CI 1.20-1.90, P = 0.01 for difference), and did not differ in their association with incident HFmrEF and HFpEF (HR 1.56, 95% CI 1.41-1.73, P = 0.68 for difference). All-cause mortality following the onset of HFmrEF was worse than that of HFpEF (50 vs. 39 events per 1000 person-years, P = 0.02), but comparable to that of HFrEF (46 events per 1000 person-years, P = 0.78).ConclusionsWe found overlap in predictors of incident HFmrEF with other HF subtypes. In contrast, mortality risk after HFmrEF was worse than HFpEF, and similar to HFrEF.

Published
2018

4. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis

Author

Rahimi, Kazem, Bidel, Zeinab, Nazarzadeh, Milad, Copland, Emma, Canoy, Dexter, Wamil, Malgorzata, Majert, Jeannette, McManus, Richard, Adler, Amanda, Agodoa, Larry, Algra, Ale, Asselbergs, Folkert W, Beckett, Nigel S, Berge, Eivind, Black, Henry, Boersma, Eric, Brouwers, Frank P J, Brown, Morris, Brugts, Jasper J, Bulpitt, Christopher J, Byington, Robert P, Cushman, William C, Cutler, Jeffrey, Devereaux, Richard B, Dwyer, Jamie P, Estacio, Ray, Fagard, Robert, Fox, Kim, Fukui, Tsuguya, Gupta, Ajay K, Holman, Rury R, Imai, Yutaka, Ishii, Masao, Julius, Stevo, Kanno, Yoshihiko, Kjeldsen, Sverre E, Kostis, John, Kuramoto, Kizuku, Lanke, Jan, Lewis, Edmund, Lewis, Julia B, Lievre, Michel, Lindholm, Lars H, Lueders, Stephan, MacMahon, Stephen, Mancia, Giuseppe, Matsuzaki, Masunori, Mehlum, Maria H, Nissen, Steven, Ogawa, Hiroshi, Ogihara, Toshio, Ohkubo, Takayoshi, Palmer, Christopher R, Patel, Anushka, Pfeffer, Marc Allan, Pitt, Bertram, Poulter, Neil R, Rakugi, Hiromi, Reboldi, Gianpaolo, Reid, Christopher, Remuzzi, Giuseppe, Ruggenenti, Piero, Saruta, Takao, Schrader, Joachim, Schrier, Robert, Sever, Peter, Sleight, Peter, Staessen, Jan A, Suzuki, Hiromichi, Thijs, Lutgarde, Ueshima, Kenji, Umemoto, Seiji, van Gilst, Wiek H, Verdecchia, Paolo, Wachtell, Kristian, Whelton, Paul, Wing, Lindon, Woodward, Mark, Yui, Yoshiki, Yusuf, Salim, Zanchetti, Alberto, Zhang, Zhen-Yu, Anderson, Craig, Baigent, Colin, Brenner, Barry Morton, Collins, Rory, de Zeeuw, Dick, Lubsen, Jacobus, Malacco, Ettore, Neal, Bruce, Perkovic, Vlado, Rodgers, Anthony, Rothwell, Peter, Salimi-Khorshidi, Gholamreza, Sundström, Johan, Turnbull, Fiona, Viberti, Giancarlo, Wang, Jiguang, Chalmers, John, Davis, Barry R, Pepine, Carl J, and Teo, Koon K

Published
2021
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5. Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

Author

Song, Ci, Burgess, Stephen, Eicher, John D, O'Donnell, Christopher J, Johnson, Andrew D, Huang, Jie, Sabater‐Lleal, Maria, Asselbergs, Folkert W, Tregouet, David, Shin, So‐Youn, Ding, Jingzhong, Baumert, Jens, Oudot‐Mellakh, Tiphaine, Folkersen, Lasse, Smith, Nicholas L, Williams, Scott M, Ikram, Mohammad A, Kleber, Marcus E, Becker, Diane M, Truong, Vinh, Mychaleckyj, Josyf C, Tang, Weihong, Yang, Qiong, Sennblad, Bengt, Moore, Jason H, Williams, Frances MK, Dehghan, Abbas, Silbernagel, Günther, Schrijvers, Elisabeth MC, Smith, Shelly, Karakas, Mahir, Tofler, Geoffrey H, Silveira, Angela, Navis, Gerjan J, Lohman, Kurt, Chen, Ming‐Huei, Peters, Annette, Goel, Anuj, Hopewell, Jemma C, Chambers, John C, Saleheen, Danish, Lundmark, Per, Psaty, Bruce M, Strawbridge, Rona J, Boehm, Bernhard O, Carter, Angela M, Meisinger, Christa, Peden, John F, Bis, Joshua C, McKnight, Barbara, Öhrvik, John, Taylor, Kent, Franzosi, Maria Grazia, Seedorf, Udo, Collins, Rory, Franco‐Cereceda, Anders, Syvänen, Ann‐Christine, Goodall, Alison H, Yanek, Lisa R, Cushman, Mary, Müller‐Nurasyid, Martina, Folsom, Aaron R, Basu, Saonli, Matijevic, Nena, van Gilst, Wiek H, Kooner, Jaspal S, Hofman, Albert, Danesh, John, Clarke, Robert, Meigs, James B, Kathiresan, Sekar, Reilly, Muredach P, Klopp, Norman, Harris, Tamara B, Winkelmann, Bernhard R, Grant, Peter J, Hillege, Hans L, Watkins, Hugh, Spector, Timothy D, Becker, Lewis C, Tracy, Russell P, März, Winfried, Uitterlinden, Andre G, Eriksson, Per, Cambien, Francois, Morange, Pierre‐Emmanuel, Koenig, Wolfgang, Soranzo, Nicole, van der Harst, Pim, Liu, Yongmei, Hamsten, Anders, Ehret, Georg B, Munroe, Patricia B, Rice, Kenneth M, Bochud, Murielle, Chasman, Daniel I, Smith, Albert V, Tobin, Martin D, and Verwoert, Germaine C

Subjects
Clinical Research, Heart Disease - Coronary Heart Disease, Cardiovascular, Heart Disease, Aging, Biomarkers, Blood Glucose, Coronary Disease, Fibrinolysis, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Incidence, Lipoproteins, HDL, Mendelian Randomization Analysis, Multivariate Analysis, Observational Studies as Topic, Odds Ratio, Plasminogen Activator Inhibitor 1, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, coronary heart disease, genome-wide association study, Mendelian randomization, plasminogen activator inhibitor type 1, single nucleotide polymorphism, genome‐wide association study, Cardiorespiratory Medicine and Haematology
Abstract

Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association studies. Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. In the systematic meta-analysis, the highest quantile of blood PAI-1 level was associated with higher CHD risk comparing with the lowest quantile (odds ratio=2.17; 95% CI: 1.53, 3.07) in an age- and sex-adjusted model. The effect size was reduced in studies using a multivariable-adjusted model (odds ratio=1.46; 95% CI: 1.13, 1.88). The Mendelian randomization analyses suggested a causal effect of increased PAI-1 level on CHD risk (odds ratio=1.22 per unit increase of log-transformed PAI-1; 95% CI: 1.01, 1.47). In addition, we also detected a causal effect of PAI-1 on elevating blood glucose and high-density lipoprotein cholesterol. Our study indicates a causal effect of elevated PAI-1 level on CHD risk, which may be mediated by glucose dysfunction.

Published
2017

7. The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

Author

Savji, Nazir, Meijers, Wouter C., Bartz, Traci M., Bhambhani, Vijeta, Cushman, Mary, Nayor, Matthew, Kizer, Jorge R., Sarma, Amy, Blaha, Michael J., Gansevoort, Ron T., Gardin, Julius M., Hillege, Hans L., Ji, Fei, Kop, Willem J., Lau, Emily S., Lee, Douglas S., Sadreyev, Ruslan, van Gilst, Wiek H., Wang, Thomas J., Zanni, Markella V., Vasan, Ramachandran S., Allen, Norrina B., Psaty, Bruce M., van der Harst, Pim, Levy, Daniel, Larson, Martin, Shah, Sanjiv J., de Boer, Rudolf A., Gottdiener, John S., and Ho, Jennifer E.

Published
2018
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8. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Author

Sotoodehnia, Nona, Isaacs, Aaron, de Bakker, Paul IW, Dörr, Marcus, Newton-Cheh, Christopher, Nolte, Ilja M, van der Harst, Pim, Müller, Martina, Eijgelsheim, Mark, Alonso, Alvaro, Hicks, Andrew A, Padmanabhan, Sandosh, Hayward, Caroline, Smith, Albert Vernon, Polasek, Ozren, Giovannone, Steven, Fu, Jingyuan, Magnani, Jared W, Marciante, Kristin D, Pfeufer, Arne, Gharib, Sina A, Teumer, Alexander, Li, Man, Bis, Joshua C, Rivadeneira, Fernando, Aspelund, Thor, Köttgen, Anna, Johnson, Toby, Rice, Kenneth, Sie, Mark PS, Wang, Ying A, Klopp, Norman, Fuchsberger, Christian, Wild, Sarah H, Leach, Irene Mateo, Estrada, Karol, Völker, Uwe, Wright, Alan F, Asselbergs, Folkert W, Qu, Jiaxiang, Chakravarti, Aravinda, Sinner, Moritz F, Kors, Jan A, Petersmann, Astrid, Harris, Tamara B, Soliman, Elsayed Z, Munroe, Patricia B, Psaty, Bruce M, Oostra, Ben A, Cupples, L Adrienne, Perz, Siegfried, de Boer, Rudolf A, Uitterlinden, André G, Völzke, Henry, Spector, Timothy D, Liu, Fang-Yu, Boerwinkle, Eric, Dominiczak, Anna F, Rotter, Jerome I, van Herpen, Gé, Levy, Daniel, Wichmann, H-Erich, van Gilst, Wiek H, Witteman, Jacqueline CM, Kroemer, Heyo K, Kao, WH Linda, Heckbert, Susan R, Meitinger, Thomas, Hofman, Albert, Campbell, Harry, Folsom, Aaron R, van Veldhuisen, Dirk J, Schwienbacher, Christine, O'Donnell, Christopher J, Volpato, Claudia Beu, Caulfield, Mark J, Connell, John M, Launer, Lenore, Lu, Xiaowen, Franke, Lude, Fehrmann, Rudolf SN, te Meerman, Gerard, Groen, Harry JM, Weersma, Rinse K, van den Berg, Leonard H, Wijmenga, Cisca, Ophoff, Roel A, Navis, Gerjan, Rudan, Igor, Snieder, Harold, Wilson, James F, Pramstaller, Peter P, Siscovick, David S, Wang, Thomas J, Gudnason, Vilmundur, van Duijn, Cornelia M, Felix, Stephan B, Fishman, Glenn I, Jamshidi, Yalda, and Ch Stricker, Bruno H

Subjects
Biological Sciences, Genetics, Cardiovascular, Heart Disease, Animals, Animals, Newborn, Chromosomes, Human, Computational Biology, Electrocardiography, Genetic Loci, Genome-Wide Association Study, Heart Conduction System, Humans, Mice, Mice, Transgenic, Models, Animal, Myocytes, Cardiac, NAV1.8 Voltage-Gated Sodium Channel, Polymorphism, Single Nucleotide, Sodium Channels, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. We performed a genome-wide association meta-analysis in 40,407 individuals of European descent from 14 studies, with further genotyping in 7,170 additional Europeans, and we identified 22 loci associated with QRS duration (P < 5 × 10(-8)). These loci map in or near genes in pathways with established roles in ventricular conduction such as sodium channels, transcription factors and calcium-handling proteins, but also point to previously unidentified biologic processes, such as kinase inhibitors and genes related to tumorigenesis. We demonstrate that SCN10A, a candidate gene at the most significantly associated locus in this study, is expressed in the mouse ventricular conduction system, and treatment with a selective SCN10A blocker prolongs QRS duration. These findings extend our current knowledge of ventricular depolarization and conduction.

Published
2010

9. Genome-wide association study identifies eight loci associated with blood pressure

Author

Newton-Cheh, Christopher, Johnson, Toby, Gateva, Vesela, Tobin, Martin D, Bochud, Murielle, Coin, Lachlan, Najjar, Samer S, Zhao, Jing Hua, Heath, Simon C, Eyheramendy, Susana, Papadakis, Konstantinos, Voight, Benjamin F, Scott, Laura J, Zhang, Feng, Farrall, Martin, Tanaka, Toshiko, Wallace, Chris, Chambers, John C, Khaw, Kay-Tee, Nilsson, Peter, van der Harst, Pim, Polidoro, Silvia, Grobbee, Diederick E, Onland-Moret, N Charlotte, Bots, Michiel L, Wain, Louise V, Elliott, Katherine S, Teumer, Alexander, Luan, Jian'an, Lucas, Gavin, Kuusisto, Johanna, Burton, Paul R, Hadley, David, McArdle, Wendy L, Brown, Morris, Dominiczak, Anna, Newhouse, Stephen J, Samani, Nilesh J, Webster, John, Zeggini, Eleftheria, Beckmann, Jacques S, Bergmann, Sven, Lim, Noha, Song, Kijoung, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Yuan, Xin, Groop, Leif, Orho-Melander, Marju, Allione, Alessandra, Di Gregorio, Alessandra, Guarrera, Simonetta, Panico, Salvatore, Ricceri, Fulvio, Romanazzi, Valeria, Sacerdote, Carlotta, Vineis, Paolo, Barroso, Inês, Sandhu, Manjinder S, Luben, Robert N, Crawford, Gabriel J, Jousilahti, Pekka, Perola, Markus, Boehnke, Michael, Bonnycastle, Lori L, Collins, Francis S, Jackson, Anne U, Mohlke, Karen L, Stringham, Heather M, Valle, Timo T, Willer, Cristen J, Bergman, Richard N, Morken, Mario A, Döring, Angela, Gieger, Christian, Illig, Thomas, Meitinger, Thomas, Org, Elin, Pfeufer, Arne, Wichmann, H Erich, Kathiresan, Sekar, Marrugat, Jaume, O'Donnell, Christopher J, Schwartz, Stephen M, Siscovick, David S, Subirana, Isaac, Freimer, Nelson B, Hartikainen, Anna-Liisa, McCarthy, Mark I, O'Reilly, Paul F, Peltonen, Leena, Pouta, Anneli, de Jong, Paul E, Snieder, Harold, van Gilst, Wiek H, Clarke, Robert, Goel, Anuj, Hamsten, Anders, and Peden, John F

Subjects
Biological Sciences, Genetics, Hypertension, Cardiovascular, Prevention, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adaptor Proteins, Signal Transducing, Blood Pressure, Cardiovascular Diseases, Chromosome Mapping, Cytochrome P-450 CYP1A2, DNA-Binding Proteins, Diastole, Europe, Fibroblast Growth Factor 5, Genetic Variation, Genome-Wide Association Study, Humans, India, Intracellular Signaling Peptides and Proteins, Methylenetetrahydrofolate Reductase (NADPH2), Open Reading Frames, Phospholipase C delta, Polymorphism, Single Nucleotide, Proteins, Steroid 17-alpha-Hydroxylase, Systole, White People, Wellcome Trust Case Control Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Published
2009

12. Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance

Author

Pozder, Carolin, primary, Screever, Elles M., additional, van der Velde, A. Rogier, additional, Silljé, Herman H., additional, Suwijn, Janne, additional, de Rond, Saskia, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, Schuringa, Jan Jacob, additional, van Gilst, Wiek H., additional, Meijers, Wouter C., additional, März, Winfried, additional, and de Boer, Rudolf A., additional

Published
2023
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13. Transitions across Kidney Disease Stages and Association with New-onset Heart Failure: a Population-Based study of 8569 Individuals and 12.6 Years of Follow-up

Author

Chen, Yuntao, primary, Bakker, Stephan JL, additional, Suthahar, Navin, additional, Meems, Laura M.G., additional, Groothof, Dion, additional, van Veldhuisen, Dirk J., additional, van Gilst, Wiek H., additional, de Boer, Rudolf A, additional, Gansevoort, Ron T, additional, Lunter, Gerton, additional, Hillege, Hans L., additional, and Postmus, Douwe, additional

Published
2023
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14. Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH

Author

van der Pol, Atze, Gil, Andres, Silljé, Herman H. W., Tromp, Jasper, Ovchinnikova, Ekaterina S., Vreeswijk-Baudoin, Inge, Hoes, Martijn, Domian, Ibrahim J., van de Sluis, Bart, van Deursen, Jan M., Voors, Adriaan A., van Veldhuisen, Dirk J., van Gilst, Wiek H., Berezikov, Eugene, van der Harst, Pim, de Boer, Rudolf A., Bischoff, Rainer, and van der Meer, Peter

Published
2017
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17. Fibroblast Growth Factor 23 and Risk of New Onset Heart Failure With Preserved or Reduced Ejection Fraction: The PREVEND Study

Author

Binnenmars, S. Heleen, primary, Hoogslag, Georgette E., additional, Yeung, Stanley M. H., additional, Brouwers, Frank P., additional, Bakker, Stephan J. L., additional, van Gilst, Wiek H., additional, Gansevoort, Ron T., additional, Navis, Gerjan, additional, Voors, Adriaan A., additional, and de Borst, Martin H., additional

Published
2022
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19. Unravelling the Difference Between Men and Women in Post-CABG Survival

Author

Onderzoek Precision medicine, CDL Cluster Speciële Diagnostiek, Circulatory Health, CDL Arcadia, Medische staf Anesthesiologie, Team Medisch, Onderzoek Vrouw Hart & Vaatziekten, Schmidt, Amand F, Haitjema, Saskia, Sartipy, Ulrik, Holzmann, Martin J, Malenka, David J, Ross, Cathy S, van Gilst, Wiek, Rouleau, Jean L, Meeder, Annelijn M, Baker, Robert A, Shiomi, Hiroki, Kimura, Takeshi, Tran, Lavinia, Smith, Julian A, Reid, Christopher M, Asselbergs, Folkert W, den Ruijter, Hester M, Onderzoek Precision medicine, CDL Cluster Speciële Diagnostiek, Circulatory Health, CDL Arcadia, Medische staf Anesthesiologie, Team Medisch, Onderzoek Vrouw Hart & Vaatziekten, Schmidt, Amand F, Haitjema, Saskia, Sartipy, Ulrik, Holzmann, Martin J, Malenka, David J, Ross, Cathy S, van Gilst, Wiek, Rouleau, Jean L, Meeder, Annelijn M, Baker, Robert A, Shiomi, Hiroki, Kimura, Takeshi, Tran, Lavinia, Smith, Julian A, Reid, Christopher M, Asselbergs, Folkert W, and den Ruijter, Hester M

Published
2022

20. Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial

Author

Westenbrink, Daan B., Alings, Marco, Granger, Christopher B., Alexander, John H., Lopes, Renato D., Hylek, Elaine M., Thomas, Laine, Wojdyla, Daniel M., Hanna, Michael, Keltai, Matyas, Steg, Gabriel P., De Caterina, Raffaele, Wallentin, Lars, and van Gilst, Wiek H.

Published
2017
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21. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

Author

Huang, Jie, Sabater-Lleal, Maria, Asselbergs, Folkert W., Tregouet, David, Shin, So-Youn, Ding, Jingzhong, Baumert, Jens, Oudot-Mellakh, Tiphaine, Folkersen, Lasse, Johnson, Andrew D., Smith, Nicholas L., Williams, Scott M., Ikram, Mohammad A., Kleber, Marcus E., Becker, Diane M., Truong, Vinh, Mychaleckyj, Josyf C., Tang, Weihong, Yang, Qiong, Sennblad, Bengt, Moore, Jason H., Williams, Frances M.K., Dehghan, Abbas, Silbernagel, Günther, Schrijvers, Elisabeth M.C., Smith, Shelly, Karakas, Mahir, Tofler, Geoffrey H., Silveira, Angela, Navis, Gerjan J., Lohman, Kurt, Chen, Ming-Huei, Peters, Annette, Goel, Anuj, Hopewell, Jemma C., Chambers, John C., Saleheen, Danish, Lundmark, Per, Psaty, Bruce M., Strawbridge, Rona J., Boehm, Bernhard O., Carter, Angela M., Meisinger, Christa, Peden, John F., Bis, Joshua C., McKnight, Barbara, Öhrvik, John, Taylor, Kent, Franzosi, Maria Grazia, Seedorf, Udo, Collins, Rory, Franco-Cereceda, Anders, Syvänen, Ann-Christine, Goodall, Alison H., Yanek, Lisa R., Cushman, Mary, Müller-Nurasyid, Martina, Folsom, Aaron R., Basu, Saonli, Matijevic, Nena, van Gilst, Wiek H., Kooner, Jaspal S., Hofman, Albert, Danesh, John, Clarke, Robert, Meigs, James B., Kathiresan, Sekar, Reilly, Muredach P., Klopp, Norman, Harris, Tamara B., Winkelmann, Bernhard R., Grant, Peter J., Hillege, Hans L., Watkins, Hugh, Spector, Timothy D., Becker, Lewis C., Tracy, Russell P., März, Winfried, Uitterlinden, Andre G., Eriksson, Per, Cambien, Francois, Morange, Pierre-Emmanuel, Koenig, Wolfgang, Soranzo, Nicole, van der Harst, Pim, Liu, Yongmei, O'Donnell, Christopher J., and Hamsten, Anders

Published
2012
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25. Sex differences in new-onset heart failure

Author

Meyer, Sven, Brouwers, Frank P., Voors, Adriaan A., Hillege, Hans L., de Boer, Rudolf A., Gansevoort, Ron T., van der Harst, Pim, Rienstra, Michiel, van Gelder, Isabelle C., van Veldhuisen, Dirk J., van Gilst, Wiek H., and van der Meer, Peter

Published
2015
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26. Unravelling the Difference Between Men and Women in Post-CABG Survival

Author

Schmidt, Amand F., primary, Haitjema, Saskia, additional, Sartipy, Ulrik, additional, Holzmann, Martin J., additional, Malenka, David J., additional, Ross, Cathy S., additional, van Gilst, Wiek, additional, Rouleau, Jean L., additional, Meeder, Annelijn M., additional, Baker, Robert A., additional, Shiomi, Hiroki, additional, Kimura, Takeshi, additional, Tran, Lavinia, additional, Smith, Julian A., additional, Reid, Christopher M., additional, Asselbergs, Folkert W., additional, and den Ruijter, Hester M., additional

Published
2022
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27. Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk

Author

Willeit, Peter, Tschiderer, Lena, Allara, Elias, Reuber, Kathrin, Seekircher, Lisa, Gao, Lu, Liao, Ximing, Lonn, Eva, Gerstein, Hertzel C, Yusuf, Salim, Brouwers, Frank P, Asselbergs, Folkert W, Van Gilst, Wiek, Anderssen, Sigmund A, Grobbee, Diederick E, Kastelein, John JP, Visseren, Frank LJ, Ntaios, George, Hatzitolios, Apostolos I, Savopoulos, Christos, Nieuwkerk, Pythia T, Stroes, Erik, Walters, Matthew, Higgins, Peter, Dawson, Jesse, Gresele, Paolo, Guglielmini, Giuseppe, Migliacci, Rino, Ezhov, Marat, Safarova, Maya, Balakhonova, Tatyana, Sato, Eiichi, Amaha, Mayuko, Nakamura, Tsukasa, Kapellas, Kostas, Jamieson, Lisa M, Skilton, Michael, Blumenthal, James A, Hinderliter, Alan, Sherwood, Andrew, Smith, Patrick J, Van Agtmael, Michiel A, Reiss, Peter, Van Vonderen, Marit GA, Kiechl, Stefan, Klingenschmid, Gerhard, Sitzer, Matthias, Stehouwer, Coen DA, Uthoff, Heiko, Zou, Zhi-Yong, Cunha, Ana R, Neves, Mario F, Witham, Miles D, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Bernal, Enrique, Wachtell, Kristian, Kjeldsen, Sverre E, Olsen, Michael H, Preiss, David, Sattar, Naveed, Beishuizen, Edith, Huisman, Menno V, Espeland, Mark A, Schmidt, Caroline, Agewall, Stefan, Ok, Ercan, Aşçi, Gülay, De Groot, Eric, Grooteman, Muriel PC, Blankestijn, Peter J, Bots, Michiel L, Sweeting, Michael J, Thompson, Simon G, Lorenz, Matthias W, PROG-IMT And The Proof-ATHERO Study Groups, Group, PROG-IMT Study, Group, Proof-ATHERO Study, Vascular Medicine, Medical Psychology, APH - Mental Health, APH - Personalized Medicine, Experimental Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Global Health, APH - Aging & Later Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Pulmonary hypertension & thrombosis, Ege Üniversitesi, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Allara, Elias [0000-0002-1634-8330], Apollo - University of Cambridge Repository, Cardiovascular Centre (CVC), Internal medicine, Nephrology, and ACS - Diabetes & metabolism

Subjects
Male, medicine.medical_specialty, Carotid Artery, Common, carotid intima-media thickness, LDL TREATMENT STRATEGIES, Myocardial Infarction, surrogate marker, TYPE-2 DIABETES-MELLITUS, HIV-INFECTED PATIENTS, 030204 cardiovascular system & hematology, Impaired glucose tolerance, EXTENDED-RELEASE NIACIN, 03 medical and health sciences, 0302 clinical medicine, IMPAIRED GLUCOSE-TOLERANCE, ESTROGEN PLUS PROGESTIN, cardiovascular disease, Physiology (medical), Internal medicine, BASE-LINE CHARACTERISTICS, medicine, Humans, CORONARY-HEART-DISEASE, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Stroke, Randomized Controlled Trials as Topic, clinical trials as topic, business.industry, Surrogate endpoint, Middle Aged, medicine.disease, Common, Clinical trial, meta-analysis, ARTERIAL-WALL THICKNESS, Intima-media thickness, JAPAN STATIN TREATMENT, Heart Disease Risk Factors, Relative risk, Meta-analysis, Cardiology, cardiovascular system, Female, Carotid Artery, Cardiology and Cardiovascular Medicine, business
Abstract

Background: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used. the primary outcome was a combined CVD end point defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD. We estimated intervention effects on cIMT progression and incident CVD for each trial, before relating the 2 using a Bayesian meta-regression approach. Results: We analyzed data of 119 randomized, controlled trials involving 100 667 patients (mean age 62 years, 42% female). Over an average follow-up of 3.7 years, 12 038 patients developed the combined CVD end point. Across all interventions, each 10 mu m/y reduction of cIMT progression resulted in a relative risk for CVD of 0.91 (95% Credible Interval, 0.87-0.94), with an additional relative risk for CVD of 0.92 (0.87-0.97) being achieved independent of cIMT progression. Taken together, we estimated that interventions reducing cIMT progression by 10, 20, 30, or 40 mu m/y would yield relative risks of 0.84 (0.75-0.93), 0.76 (0.67-0.85), 0.69 (0.59-0.79), or 0.63 (0.52-0.74), respectively. Results were similar when grouping trials by type of intervention, time of conduct, time to ultrasound follow-up, availability of individual-participant data, primary versus secondary prevention trials, type of cIMT measurement, and proportion of female patients. Conclusions: the extent of intervention effects on cIMT progression predicted the degree of CVD risk reduction. This provides a missing link supporting the usefulness of cIMT progression as a surrogate marker for CVD risk in clinical trials., Austrian Science Fund (FWF)Austrian Science Fund (FWF) [P 32488]; Dr-Johannes-and-Hertha-Tuba Foundation; German Research FoundationGerman Research Foundation (DFG) [DFG Lo 1569/2-1, DFG Lo 1569/2-3]; excellence initiative "Competence Centers for Excellent Technologies" (COMET) of the Austrian Research Promotion Agency (FFG) "Research Center of Excellence in Vascular Ageing: Tyrol, VAS-Cage" - Bundesministerium fur Verkehr, Innovation und Technologie (B [843536]; Bundesministerium fur Bildung, Wissenschaft und Forschung (BMWFW); Wirtschaftsagentur Wien; Standortagentur Tirol, This work was supported by the Austrian Science Fund (FWF; P 32488); the Dr-Johannes-and-Hertha-Tuba Foundation; the German Research Foundation (DFG Lo 1569/2-1 and DFG Lo 1569/2-3); and the excellence initiative "Competence Centers for Excellent Technologies" (COMET) of the Austrian Research Promotion Agency (FFG) "Research Center of Excellence in Vascular Ageing: Tyrol, VAS-Cage" (K-Project No. 843536), funded by Bundesministerium fur Verkehr, Innovation und Technologie (BMVIT), Bundesministerium fur Bildung, Wissenschaft und Forschung (BMWFW), Wirtschaftsagentur Wien, and Standortagentur Tirol.

Published
2020

32. Experimental and Clinical Cardiac Beta-receptor Studies

Author

Anthonio, Rutger L., van Waarde, Aren, Willemsen, Antoon T. M., Pruim, Jan, van Gilst, Wiek H., Blanksma, Paul K., Vaalburg, Willem, Lie, Kong I., van der Wall, E. E., editor, Blanksma, P. K., editor, Niemeyer, M. G., editor, and Paans, A. M. J., editor

Published
1995
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33. Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19: A Multicenter Cohort Study

Author

Sluis, Wouter M., primary, Linschoten, Marijke, additional, Buijs, Julie E., additional, Biesbroek, J. Matthijs, additional, den Hertog, Heleen M., additional, Ribbers, Tessa, additional, Nieuwkamp, Dennis J., additional, van Houwelingen, Reinier C., additional, Dias, Andreas, additional, van Uden, Ingeborg W.M., additional, Kerklaan, Joost P., additional, Bienfait, H. Paul, additional, Vermeer, Sarah E., additional, de Jong, Sonja W., additional, Ali, Mariam, additional, Wermer, Marieke J.H., additional, de Graaf, Marieke T., additional, Brouwers, Paul J.A.M., additional, Asselbergs, Folkert W., additional, Kappelle, L. Jaap, additional, van der Worp, H. Bart, additional, Algra, Annemijn M., additional, Donders, Richard C.J.M., additional, Pruissen, D. Martijn O., additional, Kuijper, Aaf F.M., additional, van Ofwegen-Hanekamp, Clara E.E., additional, Hermanides, Rik S., additional, Haerkens-Arends, Hortence E., additional, Anthonio, Rutger L., additional, Emans, Mireille E., additional, Tio, René A., additional, ten Berg, Jur M., additional, Groenemeijer, Björn E., additional, Pisters, Ron, additional, van der Zee, P. Marc, additional, Siebelink, Hans-Marc J., additional, Verschure, Derk O., additional, Meijs, Matthijs F.L., additional, Schut, Astrid, additional, Tieleman, Robert G., additional, Hermans-van Ast, Wanda, additional, Schaap, Jeroen, additional, Jewbali, Lucia S., additional, Smits, Peter C., additional, van der Harst, Pim, additional, van Smeden, Maarten, additional, and van Gilst, Wiek H., additional

Published
2021
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