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11. Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine

Author

Morleyfletcher, S, Darnaudery, M, Koehl, M, Casolini, Paola, VAN REETH, O, and Maccari, S.

Subjects
Male, Analysis of Variance, Time Factors, Behavior, Animal, Thiazepines, Reproducibility of Results, Antidepressive Agents, Tricyclic, Rats, Rats, Sprague-Dawley, Disease Models, Animal, Immobilization, Pregnancy, Stress, Physiological, Prenatal Exposure Delayed Effects, Animals, Female, Corticosterone, Swimming
Abstract

Prenatally-stressed (PS) rats are characterized by a general impairment of the hypothalamo-pituitary-adrenal (HPA) axis and sleep disturbances indicating that this model has face validity with some clinical features observed in a subpopulation of depressed patients. The prolonged corticosterone secretion shown by PS rats in response to stress was positively correlated with an increased immobility behavior in the forced swim test. To investigate the predictive validity of this model, a separate group of animals was chronically treated with the antidepressant tianeptine (10 mg/kg i.p. for 21 days). Such chronic treatment reduced in PS rats immobility time in the forced swim test. These findings suggest that the PS rat is an interesting animal model for the evaluation of antidepressant treatment.

Published
2003

12. PW01-22 - Agomelatine Treatment Reverses Changes in Neuroplasticity Induced by Prenatal Stress in Rats

Author

Mairesse, J., primary, Morley-Fletcher, S., additional, Zuena, A., additional, Soumier, A., additional, Banasr, M., additional, Casolini, P., additional, Catalani, A., additional, Fagioli, F., additional, Van Reeth, O., additional, Gabriel-Gracia, C., additional, Mocaer, E., additional, Daszuta, A., additional, Nicoletti, F., additional, and Maccari, S., additional

Published
2010
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22. Letters to the Editors

Author

van Reeth O and Unger J

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Medicine, Propylthiouracil, business, Amiodarone, medicine.drug
Published
1991
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30. Animal behaviour

Author

Van Reeth, O., primary, Zhang, Y., additional, Lesourd, M., additional, Dard‐Brunelle, B., additional, Zee, P. C., additional, and Turek, F. W., additional

Published
1993
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35. Circadian Clock Functioning Is Linked to Acute Stress Reactivity n Rats.

Author

Weibel, L., Maccari, S., and Van Reeth, O.

Subjects
PHYSIOLOGICAL stress, CIRCADIAN rhythms, CORTICOSTERONE
Abstract

At least two major physiological systems are involved in the adaptation of the organism to environmental challenges: the circadian system and the stress reaction. This study addressed the possibility that interindividual differences in stress sensitivity and in the functioning of the circadian system are related. At 2 months of age, corticosterone secretion in response to a 20-min restraint stress was assessed in 9 Sprague-Dawley rats for which running wheel activity was recorded as a rhythmic behavioral marker of the circadian clock. Two weeks later, the adaptive response of the circadian system to an abrupt shift in the light:dark (LD) cycle was assessed in those rats using a jet-lag paradigm. Finally, after resynchronization to the new LD cycle, rats were transferred to constant dark-ness to assess the free-running period of their circadian rhythm of running-wheel activity. Results indicate that stress-induced corticosterone secretion was (1) positively correlated with the number of days to resynchronize the circadian activity rhythm to the new LD cycle, and with the value of its free-running period, and (2) negatively correlated with the intensity of daily locomotor activity. Those data, emphasizing the interactions between the stress response of an organism and the functioning of its circadian system, could explain interindividual differences in humans' susceptibility to shift work or other circadian-related disorders. [ABSTRACT FROM AUTHOR]

Published
2002
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38. Hormonal and Behavioural Abnormalities Induced by Stress in utero: an Animal Model for Depression

Author

Maccari, S., Darnaudery, M., and Van Reeth, O.

Abstract

Prenatal stress in rats can exert profound influence on the offspring's development, inducing abnormalities such as increased “anxiety”, “emotionality” or “depression-like” behaviours. Prenatal stress has long-term effects on the development of the hypothalamo-pituitary-adrenal (HPA) axis and forebrain cholinergic systems. These long-term neuroendocrinological effects are mediated, at least in part, by stress-induced maternal corticosterone increase during pregnancy and stress-induced maternal anxiety during the postnatal period. We have shown a significant phase advance in the circadian rhythms of corticosterone secretion and locomotor activity in prenatally-stressed (PNS) rats. When subjected to an abrupt shift in the light-dark (LD) cycle, PNS rats resynchronized their activity rhythm more slowly than control rats. In view of the data suggesting abnormalities in the circadian timing system in these animals, we have investigated the effects of prenatal stress on the sleep-wake cycle in adult male rats. PNS rats exhibited various changes in sleep-wake parameters, including a dramatic increase in the amount of paradoxical sleep. Taken together, our results indicate that prenatal stress can induce increased responses to stress and abnormal circadian rhythms and sleep in adult rats. Various clinical observations in humans suggest a possible pathophysiological link between depression and disturbances in circadian rhythmicity. Circadian abnormalities in depression can be related to those found in PNS rats. Interestingly, we have recently shown that the increased immobility in the forced swimming test observed in PNS rats can be corrected by chronic treatment with the antidepressant tianeptine, or with melatonin or S23478, a melatonin agonist. Those results reinforce the idea of the usefulness of PNS rats as an appropriate animal model to study human depression and support a new antidepressant-like effect of melatonin and the melatonin agonist S23478.

Published
2001
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39. Rapid Correction of Hyponatraemia with Urea may Protect against Brain Damage in Rats

Author

Van Reeth, O. and Decaux, G.

Abstract

1. Rapid correction of hyponatraemia in humans has been reported to be associated with central pontine myelinolysis (CPM). In patients with hyponatraemia related to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) we have rapidly corrected hyponatraemia by using urea, without observing clinical CPM. This led us to analyse the brain damage induced by hypertonic saline and by urea when used for the correction of hyponatraemia in a rat model of SIADH. 2. Severe hyponatraemia (serum Na+ < 115 mmol/l) was produced in 28 rats. Seven rats were excluded from statistical analysis because they died during the correction of hyponatraemia, or because they were under- or over-corrected. Normalization of serum Na+ (135–146 mmol/l) was obtained in 48 h by hypertonic saline (group I, n = 7) or urea (group II, n = 8). 3. Despite similar correction of serum Na+ at 24 h and 48 h, all the rats treated with hypertonic saline presented severe brain damage, whereas those treated with urea were free of any brain damage. A third group of rats (n = 6) who spontaneously corrected their serum sodium level and presented mild hyponatraemia at 48 h (129 ± 5.2 mmol/l) were also free of any brain damage.

Published
1989
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45. Use of the new inotropic agent ARL-115 BS to treat severe myocardial depression in septic shock

Author

Kahn Rj, Van Bogaert E, Berre J, Vicent Jl, and van Reeth O

Subjects
Liver Cirrhosis, Male, Cardiotonic Agents, Septic shock, business.industry, Hemodynamics, Imidazoles, Middle Aged, Critical Care and Intensive Care Medicine, medicine.disease, Shock, Septic, Myocardial depression, Anesthesia, Bronchopneumonia, medicine, Humans, business, Inotropic agent
Published
1986
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50. A step-by-step, multidisciplinary strategy to maximize the yield of genetic testing in pediatric patients with chronic kidney diseases.

Author

Caliment A, Van Reeth O, Hougardy C, Dahan K, and Niel O

Subjects
Humans, Child, Male, Retrospective Studies, Female, Adolescent, Child, Preschool, Infant, High-Throughput Nucleotide Sequencing, Phenotype, Exome Sequencing, Genetic Testing methods, Renal Insufficiency, Chronic genetics, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic therapy
Abstract

Background: The use of genetic testing in pediatric patients with chronic kidney diseases (CKD) has increased exponentially in the past few years, particularly with the emergence of novel sequencing techniques. However, the genetic yield remains unexpectedly low in nephrology, with an impact on diagnosis, prognosis and treatment. Moreover, the increasing diversity of genetic testing possibilities can be seen as an obstacle by clinicians, in the absence of a strong background in genetics. Here, we propose a step-by-step, multidisciplinary strategy for the diagnostic evaluation of pediatric patients with CKD, and appropriate genetic test selection to maximize the yield of genetic testing., Methods: A total of 126 pediatric patients were enrolled in a retrospective file analysis. Genetic testing techniques used included phenotype-associated next-generation panel sequencing (N = 41), Sanger and SNaPshot sequencing (N = 3) and/or whole exome sequencing (N = 2)., Results: Overall genetic yield reached 63% and genetic testing significantly impacted patient management in 70%. The distribution of kidney diseases among patients was balanced and matched previously described pediatric cohorts in terms of glomerulopathies, tubulopathies and ciliopathies. Genetic analyses led to significant treatment modifications, kidney biopsy sparing and personalized nephroprotection, as well as tailored genetic counseling. Of note, the evaluation of Human Phenotype Ontology term accuracy in the cohort showed that causal mutations were precisely identified in 85% of the patients at most., Conclusion: Here we suggest a step-by-step, multidisciplinary strategy to maximize the yield of genetic testing in pediatric patients with CKD. This approach optimizes patient care while avoiding unnecessary treatments or procedures., (© 2024. The Author(s), under exclusive licence to International Pediatric Nephrology Association.)

Published
2024
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