1,068 results on '"Van Voorhis, Wesley C."'
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2. Identification of and Structural Insights into Hit Compounds Targeting N‑Myristoyltransferase for Cryptosporidium Drug Development
3. Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium
4. Rapid Epidemic Expansion of Chikungunya Virus East/Central/ South African Lineage, Paraguay
5. Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice
6. Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil
7. Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
8. Accurate de novo design of membrane-traversing macrocycles
9. Structures of Trichomonas vaginalis macrophage migratory inhibitory factor.
10. Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage
11. A short-term treatment with BKI-1294 does not protect foetuses from sheep experimentally infected with Neospora caninum tachyzoites during pregnancy
12. Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
13. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
14. In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
15. One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases
16. Unraveling the Complexity of Chikungunya Virus Infection Immunological and Genetic Insights in Acute and Chronic Patients.
17. Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis
18. Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice
19. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
20. Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms – μs) dynamics in the C-terminal helix at the dimer interface
21. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
22. P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium
23. Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis
24. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
25. Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice
26. The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
27. Development of a target identification approach using native mass spectrometry
28. In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
29. Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro
30. Structure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase
31. A comparative study of eight serological methods shows that spike protein-based ELISAs are the most accurate tests for serodiagnosing SARS-CoV-2 infections in cats and dogs
32. Clofazimine pharmacokinetics in HIV‐infected adults with diarrhea: Implications of diarrheal disease on absorption of orally administered therapeutics
33. Crystal structures of NAD(P)H nitroreductases from Klebsiella pneumoniae.
34. Rapid Discovery of Antimicrobial and Antimalarial Agents from Natural Product Fragments.
35. Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites
36. Chemical genetics of Plasmodium falciparum
37. Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection
38. Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy
39. An early treatment with BKI-1748 exhibits full protection against abortion and congenital infection in sheep experimentally infected with Toxoplasma gondii
40. Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
41. Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1
42. The Gut-Wrenching Effects of Cryptosporidiosis and Giardiasis in Children
43. Rapid Epidemic Expansion of Chikungunya Virus East/Central/South African Lineage, Paraguay
44. In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites
45. Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis
46. Extended-spectrum antiprotozoal bumped kinase inhibitors: A review
47. Conducting clinical trials in sub-Saharan Africa: challenges and lessons learned from the Malawi Cryptosporidium study
48. Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells.
49. Structure-Based Design of Submicromolar, Biologically Active Inhibitors of Trypanosomatid Glyceraldehyde-3-Phosphate Dehydrogenase
50. Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease
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