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2. Attributable mortality of candidemia – Results from the ECMM Candida III multinational European Observational Cohort Study

Author

Salmanton-García, Jon, Cornely, Oliver A., Stemler, Jannik, Barać, Aleksandra, Steinmann, Jörg, Siváková, Alena, Akalin, Emin Halis, Arikan-Akdagli, Sevtap, Loughlin, Laura, Toscano, Cristina, Narayanan, Manjusha, Rogers, Benedict, Willinger, Birgit, Akyol, Deniz, Roilides, Emmanuel, Lagrou, Katrien, Mikulska, Malgorzata, Denis, Blandine, Ponscarme, Diane, Scharmann, Urlike, Azap, Alpay, Lockhart, Deborah, Bicanic, Tihana, Kron, Florian, Erben, Nurettin, Rautemaa-Richardson, Riina, Goodman, Anna L., Garcia-Vidal, Carolina, Lass-Flörl, Cornelia, Gangneux, Jean-Pierre, Taramasso, Lucia, Ruiz, Maite, Schick, Yael, Van Wijngaerden, Eric, Milacek, Christopher, Giacobbe, Daniele Roberto, Logan, Clare, Rooney, Emily, Gori, Andrea, Akova, Murat, Bassetti, Matteo, Hoenigl, Martin, and Koehler, Philipp

Published
2024
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3. Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study

Author

Tumbarello, Mario, Talento, Alida Fe, Ruiz, Alba C, Racil, Zdenek, Stoma, Igor, Calbacho, Maria, Van Wijngaerden, Eric, Henriques, Júlia, Jordan, Harriett, Ferroni, Valentina, Ozyurt, Ozlem Koyuncu, Milacek, Christopher, Krause, Robert, Zurl, Christoph, Backx, Matthijs, Li, Ang, Seufert, Raphael, Tomazin, Rok, Blankenheim, Yael, Dávila-Valls, Julio, García-Clemente, Paloma, Freiberger, Tomas, Buil, Jochem, Meis, Jacques F, Akyol, Deniz, Guegan, Hélène, Logan, Clare, Hoenigl, Martin, Salmanton-García, Jon, Egger, Matthias, Gangneux, Jean-Pierre, Bicanic, Tihana, Arikan-Akdagli, Sevtap, Alastruey-Izquierdo, Ana, Klimko, Nikolai, Barac, Aleksandra, Özenci, Volkan, Meijer, Eelco F J, Khanna, Nina, Bassetti, Matteo, Rautemaa-Richardson, Riina, Lagrou, Katrien, Adam, Kai-Manuel, Akalin, Emin Halis, Akova, Murat, Arsic Arsenijevic, Valentina, Aujayeb, Avinash, Blennow, Ola, Bretagne, Stéphane, Danion, François, Denis, Blandine, de Jonge, Nick Alexander, Desoubeaux, Guillaume, Drgona, Lubos, Erben, Nurettin, Gori, Andrea, García Rodríguez, Julio, Garcia-Vidal, Carolina, Giacobbe, Daniele Roberto, Goodman, Anna L, Hamal, Petr, Hammarström, Helena, Toscano, Cristina, Lanternier, Fanny, Lass-Flörl, Cornelia, Lockhart, Deborah E A, Longval, Thomas, Loughlin, Laura, Matos, Tadeja, Mikulska, Malgorzata, Narayanan, Manjusha, Martín-Pérez, Sonia, Prattes, Juergen, Rogers, Benedict, Rahimli, Laman, Ruiz, Maite, Roilides, Emmanuel, Samarkos, Michael, Scharmann, Ulrike, Sili, Uluhan, Sipahi, Oguz Resat, Sivakova, Alena, Steinmann, Joerg, Trauth, Janina, Turhan, Ozge, Van Praet, Jens, Vena, Antonio, White, P Lewis, Willinger, Birgit, Tortorano, Anna Maria, Arendrup, Maiken C, Koehler, Philipp, and Cornely, Oliver A

Published
2023
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4. Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial

Author

Akova, Murat, AlAgha, Rawan, Alangaden, George, Albrecht, Svenja J, Alexander, Barbara, Al-Obaidi, Mohanad, Ambasch, German, Armestar Rodriguez, Fernando, Azap, Alpay, Baffoe-Bonnie, Anthony, Belkhir, Leila, Ben-Ami, Ronen, Boutoille, David, Cascio, Antonio, Chai, Louis YA, Chaiwarith, Romanee, Chayakulkeeree, Methee, Chen, Sharon, Chen, Yee-Chun, Chen, Yen-Hsu, Choi, Jun Yong, Choi, Young Hwa, Chotiprasitsakul, Darunee, Chung, Jin Won, Danion, François, Denis, Blandine, Diaz Santos, Emilio, Dictar, Miguel O, Diltoer, Marc, Dupont, Herve, Feng, Sizhou, Ferre Colomer, Maria Angeles, Ferrer, Ricard, Forel, Jean-Marie Fernand Roger, Fortún-Abete, Jesús, Garcia-Diaz, Julia, Girardis, Massimo, He, Fang, Hites, Maya, Ho, Mao-Wang, Honore, Patrick, Horcajada Gallego, Juan Pablo, Huang, Haihui, Huang, Po-Yen, Huang, Yong, Hussein, Osamah, Intalapaporn, Poj, Jaruratanasirikul, Sutep, Jauregui-Peredo, Luis, Johnson, Misty, Jung, Dong Sik, Jutivorakool, Kamonwan, Kern, Winfried V, Kett, Daniel H, Khawcharoenporn, Thana, Kim, Young Keun, Koehler, Philipp, Kotanidou, Anastasia, Lachiewicz, Anne, Lin, Qinhan, Lopez Cortes, Luis Eduardo, Luo, Hong, Luzzati, Roberto, Maor, Yasmin, McCarty, Todd, Merelli, Maria, Merino Amador, Paloma, Midturi, John, Migliorino, Guglielmo Marco, Mira, Jean-Paul, Mootsikapun, Piroon, Morrissey, Orla, Munoz Garcia de Paredes, Patricia, Mussini, Cristina, Mylonakis, Eleftherios, Nseir, Saadalla, Nseir, William, Odabasi, Zekaver, Papastamopoulos, Vasileios, Paterson, David, Patterson, Thomas F, Peck, Kyong Ran, Peng, Zhiyong, Permpalung, Nitipong, Plantefeve, Gaetan J, Poromanski, Ivan G, Powell, Debra, Psichogiou, Mina, Puah, Ser Hon, Pullman, John, Rahav, Galia, Martinez, Antonio Ramos, Ramos Ramos, Juan Carlos, Raz-Pasteur, Ayelet, Restrepo Castro, Carlos A, Riera, Fernando, Roblot, France, Rodriguez Alvarez, Regino Jose, Rogers, Benjamin, Roilides, Emmanuel, Sanchez Vallejo, Gregorio, Sganga, Gabriele, Sipsas, Nikolaos, Slavin, Monica, Soriano, Alex, Spec, Andrej, Strahilevitz, Jacob, Tancheva, Dora M, Tao, Zhen, Teschner, Daniel, Thompson, George R, Van Wijngaerden, Eric, Vazquez, Jose, Vergidis, Paschalis, Viale, Pierluigi, Wang, Fu-Der, Wang, Shifu, Weber, Gabriel, Weng, Jianyu, Xu, Jinfu, Yao, Li, Yavuz, Serap, Yilmaz, Mesut, Young, Jo-Anne, Zarate, Abel H, Zeng, Jun, Zhang, Yong, Thompson, George R, III, Cornely, Oliver A, Kullberg, Bart Jan, Kollef, Marin, Honore, Patrick M, Bassetti, Matteo, Poromanski, Ivan, Dignani, Cecilia, Das, Anita F, Sandison, Taylor, and Pappas, Peter G

Published
2023
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5. Full-genome next-generation sequencing of hepatitis C virus to assess the accuracy of genotyping by the commercial assay LiPA and the prevalence of resistance-associated substitutions in a Belgian cohort

Author

Christensen, Kasper T., Pierard, Florian, Beuselinck, Kurt, Bonsall, David, Bowden, Rory, Lagrou, Katrien, Nevens, Frederik, Schrooten, Yoeri, Simmonds, Peter, Vandamme, Anne-Mieke, Van Wijngaerden, Eric, Dierckx, Tim, Cuypers, Lize, and Van Laethem, Kristel

Published
2022
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7. A public health value-based healthcare paradigm for HIV

Author

Vermeersch, Sebastian, Demeester, Rémy P., Ausselet, Nathalie, Callens, Steven, De Munter, Paul, Florence, Eric, Goffard, Jean-Christophe, Henrard, Sophie, Lacor, Patrick, Messiaen, Peter, Libois, Agnès, Seyler, Lucie, Uurlings, Françoise, Vandecasteele, Stefaan J., Van Wijngaerden, Eric, Yombi, Jean-Cyr, Annemans, Lieven, and De Wit, Stéphane

Published
2022
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9. Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

Author

Liesenborghs, Laurens, Spriet, Isabel, Jochmans, Dirk, Belmans, Ann, Gyselinck, Iwein, Teuwen, Laure-Anne, ter Horst, Sebastiaan, Dreesen, Erwin, Geukens, Tatjana, Engelen, Matthias M., Landeloos, Ewout, Geldhof, Vincent, Ceunen, Helga, Debaveye, Barbara, Vandenberk, Bert, Van der Linden, Lorenz, Jacobs, Sofie, Langendries, Lana, Boudewijns, Robbert, Do, Thuc Nguyen Dan, Chiu, Winston, Wang, Xinyu, Zhang, Xin, Weynand, Birgit, Vanassche, Thomas, Devos, Timothy, Meyfroidt, Geert, Janssens, Wim, Vos, Robin, Vermeersch, Pieter, Wauters, Joost, Verbeke, Geert, De Munter, Paul, Kaptein, Suzanne J.F., Rocha-Pereira, Joana, Delang, Leen, Van Wijngaerden, Eric, Neyts, Johan, and Verhamme, Peter

Published
2021
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11. Global and regional epidemiology of HIV-1 recombinants in 1990–2015: a systematic review and global survey

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buvé, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Hervé, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Kirtley, Shona, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2020
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13. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buve, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Herve, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano Kaleebu, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Fleminger, Isabella, Kirtley, Shona, Williams, Brian, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2019
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14. The genealogical population dynamics of HIV-1 in a large transmission chain: bridging within and among host evolutionary rates.

Author

Vrancken, Bram, Rambaut, Andrew, Suchard, Marc A, Drummond, Alexei, Baele, Guy, Derdelinckx, Inge, Van Wijngaerden, Eric, Vandamme, Anne-Mieke, Van Laethem, Kristel, and Lemey, Philippe

Subjects
Humans, HIV-1, HIV Infections, Evolution, Molecular, Host-Pathogen Interactions, Evolution, Molecular, Mathematical Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

Transmission lies at the interface of human immunodeficiency virus type 1 (HIV-1) evolution within and among hosts and separates distinct selective pressures that impose differences in both the mode of diversification and the tempo of evolution. In the absence of comprehensive direct comparative analyses of the evolutionary processes at different biological scales, our understanding of how fast within-host HIV-1 evolutionary rates translate to lower rates at the between host level remains incomplete. Here, we address this by analyzing pol and env data from a large HIV-1 subtype C transmission chain for which both the timing and the direction is known for most transmission events. To this purpose, we develop a new transmission model in a Bayesian genealogical inference framework and demonstrate how to constrain the viral evolutionary history to be compatible with the transmission history while simultaneously inferring the within-host evolutionary and population dynamics. We show that accommodating a transmission bottleneck affords the best fit our data, but the sparse within-host HIV-1 sampling prevents accurate quantification of the concomitant loss in genetic diversity. We draw inference under the transmission model to estimate HIV-1 evolutionary rates among epidemiologically-related patients and demonstrate that they lie in between fast intra-host rates and lower rates among epidemiologically unrelated individuals infected with HIV subtype C. Using a new molecular clock approach, we quantify and find support for a lower evolutionary rate along branches that accommodate a transmission event or branches that represent the entire backbone of transmitted lineages in our transmission history. Finally, we recover the rate differences at the different biological scales for both synonymous and non-synonymous substitution rates, which is only compatible with the 'store and retrieve' hypothesis positing that viruses stored early in latently infected cells preferentially transmit or establish new infections upon reactivation.

Published
2014

15. Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort Using Next-Generation Sequencing of Full-Length Genomes

Author

Christensen, Kasper T., primary, Pierard, Florian, additional, Bonsall, David, additional, Bowden, Rory, additional, Barnes, Eleanor, additional, Florence, Eric, additional, Ansari, M. Azim, additional, Nguyen, Dung, additional, de Cesare, Mariateresa, additional, Nevens, Frederik, additional, Robaeys, Geert, additional, Schrooten, Yoeri, additional, Busschots, Dana, additional, Simmonds, Peter, additional, Vandamme, Anne-Mieke, additional, Van Wijngaerden, Eric, additional, Dierckx, Tim, additional, Cuypers, Lize, additional, and Van Laethem, Kristel, additional

Published
2023
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17. Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study

Author

European Study Group for Nocardia in Solid Organ Transplantation, Lebeaux, David, Freund, Romain, van Delden, Christian, Guillot, Hélène, Marbus, Sierk D., Matignon, Marie, Van Wijngaerden, Eric, Douvry, Benoit, De Greef, Julien, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Jacobs, Frédérique, Lortholary, Olivier, and Coussement, Julien

Published
2017

18. High Burden of COVID-19-Associated Pulmonary Aspergillosis in Severely Immunocompromised Patients Requiring Mechanical Ventilation

Author

Feys, Simon, primary, Lagrou, Katrien, additional, Lauwers, Hanne Moon, additional, Haenen, Koen, additional, Jacobs, Cato, additional, Brusselmans, Marius, additional, Debaveye, Yves, additional, Hermans, Greet, additional, Hoenigl, Martin, additional, Maertens, Johan, additional, Meersseman, Philippe, additional, Peetermans, Marijke, additional, Spriet, Isabel, additional, Vandenbriele, Christophe, additional, Vanderbeke, Lore, additional, Vos, Robin, additional, Van Wijngaerden, Eric, additional, Wilmer, Alexander, additional, and Wauters, Joost, additional

Published
2023
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19. A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue

Author

Vanderbeke, Lore, primary, Jacobs, Cato, additional, Feys, Simon, additional, Reséndiz-Sharpe, Agustin, additional, Debaveye, Yves, additional, Hermans, Greet, additional, Humblet-Baron, Stephanie, additional, Lagrou, Katrien, additional, Meersseman, Philippe, additional, Peetermans, Marijke, additional, Seldeslachts, Laura, additional, Vanstapel, Arno, additional, Vande Velde, Greetje, additional, Van Wijngaerden, Eric, additional, Wilmer, Alexander, additional, Verbeken, Erik, additional, De Hertogh, Gert, additional, and Wauters, Joost, additional

Published
2023
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21. Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study

Author

Hoenigl, Martin, primary, Salmanton-García, Jon, additional, Egger, Matthias, additional, Gangneux, Jean-Pierre, additional, Bicanic, Tihana, additional, Arikan-Akdagli, Sevtap, additional, Alastruey-Izquierdo, Ana, additional, Klimko, Nikolai, additional, Barac, Aleksandra, additional, Özenci, Volkan, additional, Meijer, Eelco F J, additional, Khanna, Nina, additional, Bassetti, Matteo, additional, Rautemaa-Richardson, Riina, additional, Lagrou, Katrien, additional, Adam, Kai-Manuel, additional, Akalin, Emin Halis, additional, Akova, Murat, additional, Arsic Arsenijevic, Valentina, additional, Aujayeb, Avinash, additional, Blennow, Ola, additional, Bretagne, Stéphane, additional, Danion, François, additional, Denis, Blandine, additional, de Jonge, Nick Alexander, additional, Desoubeaux, Guillaume, additional, Drgona, Lubos, additional, Erben, Nurettin, additional, Gori, Andrea, additional, García Rodríguez, Julio, additional, Garcia-Vidal, Carolina, additional, Giacobbe, Daniele Roberto, additional, Goodman, Anna L, additional, Hamal, Petr, additional, Hammarström, Helena, additional, Toscano, Cristina, additional, Lanternier, Fanny, additional, Lass-Flörl, Cornelia, additional, Lockhart, Deborah E A, additional, Longval, Thomas, additional, Loughlin, Laura, additional, Matos, Tadeja, additional, Mikulska, Malgorzata, additional, Narayanan, Manjusha, additional, Martín-Pérez, Sonia, additional, Prattes, Juergen, additional, Rogers, Benedict, additional, Rahimli, Laman, additional, Ruiz, Maite, additional, Roilides, Emmanuel, additional, Samarkos, Michael, additional, Scharmann, Ulrike, additional, Sili, Uluhan, additional, Sipahi, Oguz Resat, additional, Sivakova, Alena, additional, Steinmann, Joerg, additional, Trauth, Janina, additional, Turhan, Ozge, additional, Van Praet, Jens, additional, Vena, Antonio, additional, White, P Lewis, additional, Willinger, Birgit, additional, Tortorano, Anna Maria, additional, Arendrup, Maiken C, additional, Koehler, Philipp, additional, Cornely, Oliver A, additional, Tumbarello, Mario, additional, Talento, Alida Fe, additional, Ruiz, Alba C, additional, Racil, Zdenek, additional, Stoma, Igor, additional, Calbacho, Maria, additional, Van Wijngaerden, Eric, additional, Henriques, Júlia, additional, Jordan, Harriett, additional, Ferroni, Valentina, additional, Ozyurt, Ozlem Koyuncu, additional, Milacek, Christopher, additional, Krause, Robert, additional, Zurl, Christoph, additional, Backx, Matthijs, additional, Li, Ang, additional, Seufert, Raphael, additional, Tomazin, Rok, additional, Blankenheim, Yael, additional, Dávila-Valls, Julio, additional, García-Clemente, Paloma, additional, Freiberger, Tomas, additional, Buil, Jochem, additional, Meis, Jacques F, additional, Akyol, Deniz, additional, Guegan, Hélène, additional, and Logan, Clare, additional

Published
2023
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22. Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study

Author

European Study Group for Nocardia in Solid Organ Transplantation, Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hẻlẻne, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leϊla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cẻdric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, and Jacobs, Frédérique

Published
2016

25. Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial

Author

Thompson, George R, primary, Soriano, Alex, additional, Cornely, Oliver A, additional, Kullberg, Bart Jan, additional, Kollef, Marin, additional, Vazquez, Jose, additional, Honore, Patrick M, additional, Bassetti, Matteo, additional, Pullman, John, additional, Chayakulkeeree, Methee, additional, Poromanski, Ivan, additional, Dignani, Cecilia, additional, Das, Anita F, additional, Sandison, Taylor, additional, Pappas, Peter G, additional, Akova, Murat, additional, AlAgha, Rawan, additional, Alangaden, George, additional, Albrecht, Svenja J, additional, Alexander, Barbara, additional, Al-Obaidi, Mohanad, additional, Ambasch, German, additional, Armestar Rodriguez, Fernando, additional, Azap, Alpay, additional, Baffoe-Bonnie, Anthony, additional, Belkhir, Leila, additional, Ben-Ami, Ronen, additional, Boutoille, David, additional, Cascio, Antonio, additional, Chai, Louis YA, additional, Chaiwarith, Romanee, additional, Chen, Sharon, additional, Chen, Yee-Chun, additional, Chen, Yen-Hsu, additional, Choi, Jun Yong, additional, Choi, Young Hwa, additional, Chotiprasitsakul, Darunee, additional, Chung, Jin Won, additional, Danion, François, additional, Denis, Blandine, additional, Diaz Santos, Emilio, additional, Dictar, Miguel O, additional, Diltoer, Marc, additional, Dupont, Herve, additional, Feng, Sizhou, additional, Ferre Colomer, Maria Angeles, additional, Ferrer, Ricard, additional, Forel, Jean-Marie Fernand Roger, additional, Fortún-Abete, Jesús, additional, Garcia-Diaz, Julia, additional, Girardis, Massimo, additional, He, Fang, additional, Hites, Maya, additional, Ho, Mao-Wang, additional, Honore, Patrick, additional, Horcajada Gallego, Juan Pablo, additional, Huang, Haihui, additional, Huang, Po-Yen, additional, Huang, Yong, additional, Hussein, Osamah, additional, Intalapaporn, Poj, additional, Jaruratanasirikul, Sutep, additional, Jauregui-Peredo, Luis, additional, Johnson, Misty, additional, Jung, Dong Sik, additional, Jutivorakool, Kamonwan, additional, Kern, Winfried V, additional, Kett, Daniel H, additional, Khawcharoenporn, Thana, additional, Kim, Young Keun, additional, Koehler, Philipp, additional, Kotanidou, Anastasia, additional, Lachiewicz, Anne, additional, Lin, Qinhan, additional, Lopez Cortes, Luis Eduardo, additional, Luo, Hong, additional, Luzzati, Roberto, additional, Maor, Yasmin, additional, McCarty, Todd, additional, Merelli, Maria, additional, Merino Amador, Paloma, additional, Midturi, John, additional, Migliorino, Guglielmo Marco, additional, Mira, Jean-Paul, additional, Mootsikapun, Piroon, additional, Morrissey, Orla, additional, Munoz Garcia de Paredes, Patricia, additional, Mussini, Cristina, additional, Mylonakis, Eleftherios, additional, Nseir, Saadalla, additional, Nseir, William, additional, Odabasi, Zekaver, additional, Papastamopoulos, Vasileios, additional, Paterson, David, additional, Patterson, Thomas F, additional, Peck, Kyong Ran, additional, Peng, Zhiyong, additional, Permpalung, Nitipong, additional, Plantefeve, Gaetan J, additional, Poromanski, Ivan G, additional, Powell, Debra, additional, Psichogiou, Mina, additional, Puah, Ser Hon, additional, Rahav, Galia, additional, Martinez, Antonio Ramos, additional, Ramos Ramos, Juan Carlos, additional, Raz-Pasteur, Ayelet, additional, Restrepo Castro, Carlos A, additional, Riera, Fernando, additional, Roblot, France, additional, Rodriguez Alvarez, Regino Jose, additional, Rogers, Benjamin, additional, Roilides, Emmanuel, additional, Sanchez Vallejo, Gregorio, additional, Sganga, Gabriele, additional, Sipsas, Nikolaos, additional, Slavin, Monica, additional, Spec, Andrej, additional, Strahilevitz, Jacob, additional, Tancheva, Dora M, additional, Tao, Zhen, additional, Teschner, Daniel, additional, Thompson, George R, additional, Van Wijngaerden, Eric, additional, Vergidis, Paschalis, additional, Viale, Pierluigi, additional, Wang, Fu-Der, additional, Wang, Shifu, additional, Weber, Gabriel, additional, Weng, Jianyu, additional, Xu, Jinfu, additional, Yao, Li, additional, Yavuz, Serap, additional, Yilmaz, Mesut, additional, Young, Jo-Anne, additional, Zarate, Abel H, additional, Zeng, Jun, additional, and Zhang, Yong, additional

Published
2023
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27. Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

Author

Engelen, Matthias M., primary, Van Thillo, Quentin, additional, Betrains, Albrecht, additional, Gyselinck, Iwein, additional, Martens, Caroline P., additional, Spalart, Valérie, additional, Ockerman, Anna, additional, Devooght, Caroline, additional, Wauters, Joost, additional, Gunst, Jan, additional, Wouters, Carine, additional, Vandenbriele, Christophe, additional, Rex, Steffen, additional, Liesenborghs, Laurens, additional, Wilmer, Alexander, additional, Meersseman, Philippe, additional, Van den Berghe, Greet, additional, Dauwe, Dieter, additional, Belmans, Ann, additional, Thomeer, Michiel, additional, Fivez, Tom, additional, Mesotten, Dieter, additional, Ruttens, David, additional, Heytens, Luc, additional, Dapper, Ilse, additional, Tuyls, Sebastiaan, additional, De Tavernier, Brecht, additional, Verhamme, Peter, additional, Vanassche, Thomas, additional, Van Wijngaerden, Eric, additional, Janssens, Wim, additional, Meyfroidt, Geert, additional, Vos, Robin, additional, Devos, Timothy, additional, De Munter, Paul, additional, Neyts, Johan, additional, Dupont, Lieven, additional, Spriet, Isabel, additional, Verbeke, Geert, additional, Claes, Kathleen, additional, Robberecht, Wim, additional, Van Geet, Chris, additional, Debaveye, Barbara, additional, Ceunen, Helga, additional, Servaes, Veerle, additional, Cludts, Katrien, additional, Vanheule, Kristine, additional, Jacobs, Cato, additional, Roebroek, Daimy, additional, Dreesen, Paulien, additional, Smet, Nele, additional, Dolhain, Jan, additional, Hoppenbrouwers, Mieke, additional, Wens, Kathleen, additional, Daems, Kristel, additional, and D’hondt, Monique, additional

Published
2022
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29. A public health value-based healthcare paradigm for HIV.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Pathologie infectieuse, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Vermeersch, Sebastian, Demeester, Rémy P, Ausselet, Nathalie, Callens, Steven, De Munter, Paul, Florence, Eric, Goffard, Jean-Christophe, Henrard, Sophie, Lacor, Patrick, Messiaen, Peter, Libois, Agnès, Seyler, Lucie, Uurlings, Françoise, Vandecasteele, Stefaan J, Van Wijngaerden, Eric, Yombi, Jean Cyr, Annemans, Lieven, De Wit, Stéphane, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Pathologie infectieuse, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Vermeersch, Sebastian, Demeester, Rémy P, Ausselet, Nathalie, Callens, Steven, De Munter, Paul, Florence, Eric, Goffard, Jean-Christophe, Henrard, Sophie, Lacor, Patrick, Messiaen, Peter, Libois, Agnès, Seyler, Lucie, Uurlings, Françoise, Vandecasteele, Stefaan J, Van Wijngaerden, Eric, Yombi, Jean Cyr, Annemans, Lieven, and De Wit, Stéphane

Abstract

BACKGROUND: HIV patients face considerable acute and chronic healthcare needs and battling the HIV epidemic remains of the utmost importance. By focusing on health outcomes in relation to the cost of care, value-based healthcare (VBHC) proposes a strategy to optimize quality of care and cost-efficiency. Its implementation may provide an answer to the increasing pressure to optimize spending in healthcare while improving patient outcomes. This paper describes a pragmatic value-based healthcare framework for HIV care. METHODS: A value-based HIV healthcare framework was developed during a series of roundtable discussions bringing together 16 clinical stakeholder representatives from the Belgian HIV reference centers and 2 VBHC specialists. Each round of discussions was focused on a central question translating a concept or idea to the next level of practical implementation: 1) how can VBHC principles be translated into value-based HIV care drivers; 2) how can these value-based HIV care divers be translated into value-based care objectives and activities; and 3) how can value-based HIV care objectives and activities be translated into value-based care indicators. Value drivers were linked to concrete objectives and activities using a logical framework approach. Finally, specific, measurable, and acceptable structure, process and outcomes indicators were defined to complement the framework. RESULTS: Our framework identifies 4 core value areas where HIV care would benefit most from improvements: Prevention, improvement of the cascade of care, providing patient-centered HIV care and sustaining a state-of-the-art HIV disease management context. These 4 core value areas were translated into 12 actionable core value objectives. For each objective, example activities were proposed. Indicators are suggested for each level of the framework (outcome indicators for value areas and objectives, process indicators for suggested activities). CONCLUSIONS: This framework approach outlin

Published
2022

34. Lessons in Developing a Full-Genome Next-Generation Sequencing Pipeline for Molecular Epidemiology of Hcv

Author

Christensen, Kasper Thorhauge, primary, Pierard, Florian, additional, Schrooten, Yoeri, additional, Bonsall, David, additional, Bowden, Rory, additional, Simmonds, Peter, additional, Dierckx, Tim, additional, Nevens, Frederik, additional, Van Wijngaerden, Eric, additional, Robaeys, Geert, additional, Florence, Eric, additional, Vandamme, Anne-Mieke, additional, Cuypers, Lize, additional, and Van Laethem, Kristel, additional

Published
2022
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37. Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1 infected patients: 336-week rollover study of phase 2b and 3 clinical studies

Author

Molina, Jean Michel, primary, Ene, Luminita, additional, Cahn, Pedro, additional, Fätkenheuer, Gerd, additional, Van Wijngaerden, Eric, additional, Lombaard, Johan, additional, Zakharova, Natalia, additional, Van Eygen, Veerle, additional, Vanveggel, Simon, additional, and Van Solingen-Ristea, Rodica, additional

Published
2021
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38. Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”

Author

Liesenborghs, Laurens, primary, Spriet, Isabel, additional, Jochmans, Dirk, additional, Belmans, Ann, additional, Gyselinck, Iwein, additional, Teuwen, Laure-Anne, additional, ter Horst, Sebastiaan, additional, Dreesen, Erwin, additional, Geukens, Tatjana, additional, Engelen, Matthias M., additional, Landeloos, Ewout, additional, Geldhof, Vincent, additional, Ceunen, Helga, additional, Debaveye, Barbara, additional, Vandenberk, Bert, additional, Van der Linden, Lorenz, additional, Jacobs, Sofie, additional, Langendries, Lana, additional, Boudewijns, Robbert, additional, Dan Do, Thuc Nguyen, additional, Chiu, Winston, additional, Wang, Xinyu, additional, Zhang, Xin, additional, Weynand, Birgit, additional, Vanassche, Thomas, additional, Devos, Timothy, additional, Meyfroidt, Geert, additional, Janssens, Wim, additional, Vos, Robin, additional, Vermeersch, Pieter, additional, Wauters, Joost, additional, Verbeke, Geert, additional, De Munter, Paul, additional, Kaptein, Suzanne J.F., additional, Rocha-Pereira, Joana, additional, Delang, Leen, additional, Van Wijngaerden, Eric, additional, Neyts, Johan, additional, and Verhamme, Peter, additional

Published
2021
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39. sj-pdf-1-avt-10.1177_13596535211062388 ��� Supplemental Material for Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1-infected patients: 336-week rollover study of phase 2b and 3 clinical studies

Author

Molina, Jean Michel, Ene, Luminita, Cahn, Pedro, F��tkenheuer, Gerd, Van Wijngaerden, Eric, Lombaard, Johan, Zakharova, Natalia, Van Eygen, Veerle, Vanveggel, Simon, and Van Solingen-Ristea, Rodica

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-avt-10.1177_13596535211062388 for Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1-infected patients: 336-week rollover study of phase 2b and 3 clinical studies by Jean Michel Molina, Luminita Ene, Pedro Cahn, Gerd F��tkenheuer, Eric Van Wijngaerden, Johan Lombaard, Natalia Zakharova, Veerle Van Eygen, Simon Vanveggel and Rodica Van Solingen-Ristea in Antiviral Therapy

Published
2021
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40. Long-term safety and efficacy of rilpivirine in combination with nucleoside/nucleotide reverse transcriptase inhibitors in HIV-1 infected patients: 336-week rollover study of phase 2b and 3 clinical studies

Author

Molina, Jean Michel, Ene, Luminita, Cahn, Pedro, Faetkenheuer, Gerd, Van Wijngaerden, Eric, Lombaard, Johan, Zakharova, Natalia, Van Eygen, Veerle, Vanveggel, Simon, Van Solingen-Ristea, Rodica, Molina, Jean Michel, Ene, Luminita, Cahn, Pedro, Faetkenheuer, Gerd, Van Wijngaerden, Eric, Lombaard, Johan, Zakharova, Natalia, Van Eygen, Veerle, Vanveggel, Simon, and Van Solingen-Ristea, Rodica

Abstract

Background To evaluate the long-term safety and efficacy of rilpivirine (RPV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), in combination with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) in human immunodeficiency virus (HIV)-infected patients. Methods RPV-treated HIV-infected patients from phase 2b or 3 studies rolled-over into this phase 3, open-label study and received RPV 25 mg once daily (QD) with choice of two NRTIs. Adverse events (AEs), plasma viral load, CD4(+) cell count, and antiviral resistance were evaluated. Results Of the 482 patients treated, 437 (>90%) patients discontinued study treatment; 371 (77%) had switched to commercially available RPV, 14 (2.9%) discontinued due to AEs, and 6 (1.2%) had virologic failure. In this rollover study, patients were followed up to week 336, although data was limited beyond 288 weeks. Forty-five (9.3%) patients were still undergoing treatment at the time of data cut-off for the current analysis (8 February 2018). The most frequently reported AEs were pregnancy in 7 (1.5%) patients and syphilis in 5 (1.0%) patients. Grade 3-4 AEs were reported in 17 (3.5%) patients, and AEs possibly related to RPV in 23 (4.8%) patients. Over 288 weeks of treatment, 80.1% (95% CI: 74.9%; 84.3%) of patients maintained virologic suppression (HIV-1 RNA <50 copies/mL). The absolute CD4(+) cell count increased over time until week 192 and remained constant thereafter. Conclusions RPV 25 mg QD in combination with an investigator-selected background regimen of two NRTIs demonstrated sustained long-term virologic suppression. The treatment was well-tolerated with no new safety findings.

Published
2021

42. Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from AASERT study

Author

Stellbrink, Hans-Jurgen, Orkin, Chloe, Arribas, Jose Ramon, Compston, Juiet, Gerstoft, Jan, Van Wijngaerden, Eric, Lazzarin, Adriano, Rizzardini, Giuliano, Sprenger, Herman G., Lambert, John, Sture, Gunta, Leather, David, Hughes, Sara, Zucchi, Patrizia, and Pearce, Helen

Subjects
Drug therapy, Combination -- Safety and security measures, Drug therapy, Combination -- Research, Antiviral agents -- Dosage and administration, Antiviral agents -- Complications and side effects, Antiviral agents -- Research, Highly active antiretroviral therapy -- Patient outcomes, Highly active antiretroviral therapy -- Demographic aspects, Highly active antiretroviral therapy -- Research, Bones -- Density, Bones -- Comparative analysis, Bones -- Demographic aspects, Health, Health care industry
Published
2010

44. Diagnostic value of different adherence measures using electronic monitoring and virologic failure as reference standards

Author

Deschamps, Ann E., De Geest, Sabina, Vandamme, Anne-Mieke, Bobbaers, Herman, Peetermans, Willy E., and Van Wijngaerden, Eric

Subjects
AIDS treatment -- Standards, HIV infection -- Care and treatment, Highly active antiretroviral therapy -- Standards, Health
Abstract

Nonadherence to antiretroviral therapy is a substantial problem in HIV and jeopardizes the success of treatment. Accurate measurement of nonadherence is therefore imperative for good clinical management but no gold standard has been agreed on yet. In a single-center prospective study nonadherence was assessed by electronic monitoring: percentage of doses missed and drug holidays and by three self reports: (1) a visual analogue scale (VAS): percentage of overall doses taken; (2) the Swiss HIV Cohort Study Adherence Questionnaire (SHCS-AQ): percentage of overall doses missed and drug holidays and (3) the European HIV Treatment Questionnaire (EHTQ): percentage of doses missed and drug holidays for each antiretroviral drug separately. Virologic failure prospectively assessed during 1 year, and electronic monitoring were used as reference standards. Using virologic failure as reference standard, the best results were for (1) the SHCS-AQ after electronic monitoring (sensitivity, 87.5%; specificity, 78.6%); (2) electronic monitoring (sensitivity, 75%; specificity, 85.6%), and (3) the VAS combined with the SHCS-AQ before electronic monitoring (sensitivity, 87.5%; specificity, 58.6%). The sensitivity of the complex EHTQ was less than 50%. Asking simple questions about doses taken or missed is more sensitive than complex questioning about each drug separately. Combining the VAS with the SHCS-AQ seems a feasible nonadherence measure for daily clinical practice. Self-reports perform better after electronic monitoring: their diagnostic value could be lower when given independently.

Published
2008

45. Invasive aspergillosis in the intensive care unit

Author

Meersseman, Wouter, Lagrou, Katrien, Maertens, Johan, and Van Wijngaerden, Eric

Subjects
Aspergillosis -- Diagnosis, Aspergillosis -- Risk factors, Aspergillosis -- Research, Intensive care units -- Research, Health, Health care industry
Published
2007

46. Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert M, Wunderink, Herman F, Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, Candon, Sophie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert M, Wunderink, Herman F, Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, and Candon, Sophie

Abstract

Dear Editors, Nocardiosis is a rare but potentially severe bacterial opportunistic infection that may occur after solid organ transplantation (SOT), typically among thoracic transplant recipients and/or in recipients with a high degree of immunosuppression due to anti-rejection therapy [1]. However, nocardiosis may also occur late after transplantation among minimally immunosuppressed patients, suggesting that additional risk factors exist [1]. Recently, autoantibodies against granulocyte macrophage colony-stimulating factor (GM-CSF) have been identified among five previously healthy patients with disseminated nocardiosis [2]. These autoantibodies likely promote nocardiosis by reducing neutrophil and macrophage activation, phagocytosis, and bactericidal activity [2]. We hypothesized that anti-GM-CSF autoantibodies might be involved in post-SOT nocardiosis, especially in patients who apparently have a relatively low degree of immunosuppression. [...]

Published
2020

47. Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients

Author

Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert A.M., Wunderink, Herman H.F., Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, Candon, Sophie, Lebeaux, David, Coussement, Julien, Chauvet, Cécile, Matignon, Marie, Scemla, Anne, Bouvier, Nicolas, Dantal, Jacques, Vollaard, Albert A.M., Wunderink, Herman H.F., Van Wijngaerden, Eric, Naesens, Maarten, Kamar, Nassim, De Greef, Julien, Guillemain, Romain, Borie, Raphael, and Candon, Sophie

Abstract

SCOPUS: le.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

48. Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Author

Ceulemans, Laurens J, primary, Van Slambrouck, Jan, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Ceuterick, Vincent, additional, Verleden, Stijn E, additional, Vanstapel, Arno, additional, Desmet, Stefanie, additional, Maes, Piet, additional, Van Ranst, Marc, additional, Lormans, Piet, additional, Meyfroidt, Geert, additional, Neyrinck, Arne P, additional, Vanaudenaerde, Bart M, additional, Van Wijngaerden, Eric, additional, Bos, Saskia, additional, Godinas, Laurent, additional, Carmeliet, Peter, additional, Verleden, Geert M, additional, Van Raemdonck, Dirk E, additional, and Vos, Robin, additional

Published
2021
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49. Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using medication event monitoring system[R]

Author

Deschamps, Ann E., De Graeve, Veerle, Van Wijngaerden, Eric, De Saar, Veerle, Vandamme, Anne-Mieke, Van Vaerenbergh, Kristien, Ceunen, Helga, Bobbaers, Herman, Peetermans, Willy E., De Vleeschouwer, Peter J., and De Geest, Sabina

Subjects
Highly active antiretroviral therapy -- Health aspects, HIV patients -- Drug therapy, Antiviral agents -- Dosage and administration, Health
Abstract

Nonadherence to antiretroviral therapy (ART) jeopardizes good clinical outcome in people living with HIV. In a single-center prospective study, prevalence and correlates of nonadherence were investigated in 43 patients on ART. Nonadherence was assessed using Medication Event Monitoring System[R] (MEMS[R]), self-report and collateral report of treating physicians. Based on MEMS[R] data, median taking adherence, dosing adherence, and timing adherence was 98% (interquartile range [IQR] = 5.3), 91.5% (IQR = 18), and 86% (IQR = 31.5), respectively. The median number of drug holidays per 100 days was 0.8 (IQR = 4.8). The prevalence of nonadherence measured by MEMS[R] was 40%. Self-reported nonadherence and collateral report of nonadherence by physicians varied from 5% to 41% and 24% to 28%, respectively. Patients were categorized as adherent or nonadherent based on a clinically validated algorithm derived from MEMS[R] parameters. Nonadherent patients used significantly more escaping coping strategies (p = 0.003) and planned problem solving strategies (p = 0.049), were prescribed significantly more antiretroviral medications (p = 0.02) and were significantly longer on ART (p = 0.04) than adherent patients. Identified correlates of nonadherence may help clinicians in detecting patients with HIV at risk for nonadherence and can support the development of adherence enhancing interventions.

Published
2004

50. RegaDB: community-driven data management and analysis for infectious diseases

Author

Libin, Pieter, Beheydt, Gertjan, Deforche, Koen, Imbrechts, Stijn, Ferreira, Fossie, Van Laethem, Kristel, Theys, Kristof, Carvalho, Ana Patricia, Cavaco-Silva, Joana, Lapadula, Giuseppe, Torti, Carlo, Assel, Matthias, Wesner, Stefan, Snoeck, Joke, Ruelle, Jean, De Bel, Annelies, Lacor, Patrick, De Munter, Paul, Van Wijngaerden, Eric, Zazzi, Maurizio, Kaiser, Rolf, Ayouba, Ahidjo, Peeters, Martine, de Oliveira, Tulio, Alcantara, Luiz C. J., Grossman, Zehava, Sloot, Peter, Otelea, Dan, Paraschiv, Simona, Boucher, Charles, Camacho, Ricardo J., and Vandamme, Anne-Mieke

Published
2013
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