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Your search keyword '"Van den Bosch, Lisa"' showing total 17 results
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17 results on '"Van den Bosch, Lisa"'

8. 1236: Towards the global integration of a comprehensive toxicity risk profile for HNC patients

Author

de Vette, Suzanne P.M., van Rijn-Dekker, Maria I., van den Bosch, Lisa, Keijzer, Kylie, Neh, Hendrike, Chu, Hung, Li, Yan, Frederiks, Mark L., van der Laan, Hans Paul, Heukelom, Jolien, van der Schaaf, Arjen, Hutcheson, Katherine A., Steenbakkers, Roel J.H.M., Sijtsema, Nanna M., Fuller, Clifton D., Langendijk, Johannes A., Moreno, Amy C., and van Dijk, Lisanne V.

Published
2024
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9. Risk-based treatment optimisation to reduce radiation-induced toxicity in head and neck cancer patients

Author

Van den Bosch, Lisa and Van den Bosch, Lisa

Abstract

Radiotherapy plays an important role in the treatment of head and neck cancer (HNC) patients. However, the tumour cannot be adequately radiated without irradiating healthy normal tissue as well. Irradiation of healthy tissues results in numerous toxicities (e.g., xerostomia (dry mouth syndrome) or severe swallowing problems) that significantly impair their quality of life. New radiotherapy treatment techniques, like protons, enable a more precise irradiation of the tumour, thereby reducing the radiation dose to these healthy tissues. The main challenge is how to arrive at the 3D dose distribution that cures patients with the lowest toxicity burden. This process requires detailed information on the relationship between the 3D dose distribution and the risk of toxicities. This relationship is described in multivariable prediction models, commonly referred to as Normal Tissue Complication Probability (NTCP) models. In this thesis we developed and validated a comprehensive set of NTCP models that predict the risk of various common radiation-induced toxicities. Together these NTCP models converge into a corresponding risk profile, the Comprehensive Individual Toxicity Risk (CITOR) profile. It provides new insight into the involvement of healthy tissues in the development of toxicities, indicating which healthy tissues are more important to spare. The oral cavity appears to be the predominant healthy tissue that is associated with multiple toxicities and should therefore be spared with a high priority. Some of the NTCP models of this CITOR profile are currently used nationally in clinical practice to optimise the dose distribution and to select HNC patients for proton therapy.

Published
2022

10. Impact of sarcopenia on acute radiation-induced toxicity in head and neck cancer patients

Author

Karavolia, Eleftheria, primary, van Rijn-Dekker, Maria I., additional, Van den Bosch, Lisa, additional, van den Hoek, Johanna G.M., additional, Oldehinkel, Edwin, additional, Meijer, Tineke W.H., additional, Halmos, Gyorgy B., additional, Witjes, Max J.H., additional, Oosting, Sjoukje F., additional, van der Hoorn, Anouk, additional, Langendijk, Johannes A., additional, and Steenbakkers, Roel J.H.M., additional

Published
2022
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12. Comprehensive toxicity risk profiling in radiation therapy for head and neck cancer: A new concept for individually optimised treatment

Author

Van den Bosch, Lisa, primary, van der Schaaf, Arjen, additional, van der Laan, Hans Paul, additional, Hoebers, Frank J.P., additional, Wijers, Oda B., additional, van den Hoek, Johanna G.M., additional, Moons, Karel G.M., additional, Reitsma, Johannes B., additional, Steenbakkers, Roel J.H.M., additional, Schuit, Ewoud, additional, and Langendijk, Johannes A., additional

Published
2021
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15. Impact of sarcopenia on survival and late toxicity in head and neck cancer patients treated with radiotherapy

Author

van Rijn-Dekker, Maria I., primary, van den Bosch, Lisa, additional, van den Hoek, Johanna G.M., additional, Bijl, Hendrik P., additional, van Aken, Evert S.M., additional, van der Hoorn, Anouk, additional, Oosting, Sjoukje F., additional, Halmos, Gyorgy B., additional, Witjes, Max J.H., additional, van der Laan, Hans P., additional, Langendijk, Johannes A., additional, and Steenbakkers, Roel J.H.M., additional

Published
2020
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17. Is there a different dose–effect relation between the primary tumor and involved lymph nodes in locally advanced non-small-cell lung cancer? A hypothesis-generating study.

Author

Van den Bosch, Lisa, Defraene, Gilles, Peeters, Stéphanie, Dooms, Christophe, De Wever, Walter, Deroose, Christophe, and De Ruysscher, Dirk

Subjects
*ESOPHAGUS diseases, *DOSE-response relationship (Radiation), *LUNG cancer, *LYMPH nodes, *REGRESSION analysis, *RETROSPECTIVE studies, *CHEMORADIOTHERAPY, *PREVENTION
Abstract

Purpose:It is unknown whether the dose–response relation of the primary tumor in NSCLC is different from that of the involved lymph nodes (LN). As the recurrence rate is much lower in LN, we hypothesized that LN need a lower radiation dose. Material and methods:A retrospective analysis of prospective data was performed on patients with locally advanced NSCLC treated with (chemo)radiotherapy. The impact of EQD2,Tprescription dose on relapse was analyzed using Cox regression modeling correcting for baseline diameter. Results:From 2006 to 2010, 75 consecutive patients were included, resulting in 142 lymph nodes in the analysis. Any relapse (locoregional/distant) occurred in 58 patients (77%), while involved nodal relapse (INR) was observed in 13% of patients. No dose–response relationship was observed for INR (p = .22). Primary tumor progression was seen in 40% of patients together with a significant dose–response relationship (p = .033). Baseline nodal diameter was not associated with INR (p = .76), while primary tumor diameter was a highly significant predictor for relapse (p = .0031). Conclusions:These results suggest that LN control may be achieved at lower radiation doses than needed for the primary tumor. Prospective dose de-escalation studies on LN are warranted to decrease the incidence of severe esophagitis without compromising local tumor control. [ABSTRACT FROM PUBLISHER]

Published
2017
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