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12 results on '"VanderLaan, Don"'

3. Regulating Interparticle Proximity in Plasmonic Nanosphere Aggregates to Enhance Photoacoustic Response and Photothermal Stability.

Author

Kim, Myeongsoo, Kubelick, Kelsey P., Yu, Anthony M., VanderLaan, Don, Jhunjhunwala, Anamik, Nikolai, Robert J., Cadena, Melissa, Kim, Jinhwan, and Emelianov, Stanislav Y.

Subjects
PLASMONICS, THERMAL conductivity, CONTRAST media, NANOSTRUCTURED materials, HEAT transfer
Abstract

Designing plasmonic nanoparticles for biomedical photoacoustic (PA) imaging involves tailoring material properties at the nanometer scale. A key in developing plasmonic PA contrast nanoagents is to engineer their enhanced optical responses in the near‐infrared wavelength range, as well as heat transfer properties and photostability. This study introduces anisotropic plasmonic nanosphere aggregates with close interparticle proximity as photostable and efficient contrast agents for PA imaging. Silver (Ag) is particularly attractive because it has the strongest optical response and highest heat conductivity among plasmonic metals. The results demonstrate that close interparticle proximity in silver nanoaggregates (AgNAs), spatially confined within a polymer shell layer, leads to blackbody‐like optical absorption, resulting in robust PA signals through efficient pulsed heat generation and transfer. Additionally, the AgNAs exhibit a high photodamage threshold highlighting their potential to outperform conventional plasmonic contrast agents for high‐contrast PA imaging over multiple imaging sessions. Furthermore, the capability of the AgNAs are demonstrated for molecular PA cancer imaging in vivo by incorporating a tumor‐targeting peptide moiety. [ABSTRACT FROM AUTHOR]

Published
2024
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6. In vivo safety study using radiation at wavelengths and dosages relevant to intravascular imaging

Author

Sowers, Timothy, VanderLaan, Don, Karpiouk, Andrei, Onohara, Daisuke, Schmarkey, Susan, Rousselle, Serge, Padala, Muralidhar, and Emelianov, Stanislav

Subjects
Paper, safety, Diagnostic Imaging, Swine, Lasers, Biomedical Engineering, Plaque, Atherosclerotic, Atomic and Molecular Physics, and Optics, Imaging, laser, Electronic, Optical and Magnetic Materials, Biomaterials, in vivo, Animals, intravascular, photoacoustics
Abstract

Significance: Intravascular photoacoustic (IVPA) imaging can identify native lipid in atherosclerotic plaques in vivo. However, the large number of laser pulses required to produce 3D images is a safety concern that has not been fully addressed. Aim: We aim to evaluate if irradiation at wavelengths and dosages relevant to IVPA imaging causes target vessel damage. Approach: We irradiate the carotid artery of swine at one of several energy dosages using radiation at 1064 or 1720 nm and use histological evaluation by a pathologist to identify dose-dependent damage. Results: Media necrosis was the only dose-dependent form of injury. Damage was present at a cumulative fluence of 50 J/cm2 when using 1720 nm light. Damage was more equivocally identified at 700 J/cm2 using 1064 nm. Conclusions: In prior work, IVPA imaging of native lipid in swine has been successfully conducted below the damage thresholds identified. This indicates that it will be possible to use IVPA imaging in a clinical setting without damaging vessel tissue. Future work should determine if irradiation causes an increase in blood thrombogenicity and confirm whether damaged tissue will heal over longer time points.

Published
2022

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