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302 results on '"Vanek, Tomas"'

4. Field Study VI: The Effect of Loading Strategies on Removal Efficiencies of a Hybrid Constructed Wetland Treating Mixed Domestic and Agro-Industrial Wastewaters

Author

Šereš, Michal, Hnátková, Tereza, Maršík, Petr, Vaněk, Tomáš, Soudek, Petr, Vymazal, Jan, Jegatheesan, Jega V., Series Editor, Shu, Li, Series Editor, Lens, Piet, Series Editor, Chiemchaisri, Chart, Series Editor, Filip, Jan, editor, Cajthaml, Tomáš, editor, Najmanová, Petra, editor, Černík, Miroslav, editor, and Zbořil, Radek, editor

Published
2020
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10. Lower dose of sufentanil was associated with higher plasmatic level of cortisol in patients undergoing elective cardiac surgery at the same depth of anaesthesia: a prospective randomised pilot study. Do we overlook 'stress under the surface'?

Author

Rogozov, Vladislav, Vanek, Tomas, Maly, Marek, Kacer, Petr, and Musil, Vladimir

Subjects
*CARDIAC surgery, *SUFENTANIL, *HYDROCORTISONE, *SYMPATHETIC nervous system, *ANESTHESIA
Abstract

Objective monitoring of per-operative nociception remains an unanswered challenge. Anaesthetists still mostly rely on signs of activation of the sympathetic nervous system, e.g., an increase in heart rate and blood pressure. These signs can be often blurred in cardiac surgery because of medication influencing heart rate and blood pressure or by severe hemodynamic disturbances. Such conditions create the potential for incompletely checked nociception which can lead to unrecognised “under the surface” stress reaction. We decided to investigate whether patients undergoing cardiac surgery maintained at the same level of monitored depth of anaesthesia would express differences in plasmatic level of stress hormone cortisol when given a different dose of opioid sufentanil. Nineteen patients undergoing elective cardiac surgery were included in our prospective randomised trial. All patients were anaesthetised by a standardised protocol (using midazolam, propofol, sevoflurane, sufentanil and rocuronium) and were maintained within the same range of anaesthetic depth monitored by monitor Conox (qCON 30–50). Patients were randomised in two groups. Group LS (lower sufentanil), n = 9, recieved TCI (target controlled infusion) sufentanil in dose of 0.25 ng/mL, group HS (higher sufentanil), n = 10, in dose of 0.75 ng/mL. 15 minutes after sternotomy we took blood samples for analysis of plasmatic levels of cortisol. Group LS had significantly higher plasmatic cortisol levels, median 700 nm/L, than HS, median 328 nm/L (p = 0.006). We conclude that a lower dose of sufentanil was associated with higher plasmatic level of cortisol and thus more significant activation of hypothalamic–pituitary–adrenal axis stress response. We emphasise that activation of stress response can be underestimated during cardiac surgery. Our result supports the need for developing an objective monitoring method of per-operative nociception. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Developing and Implementing a Combined Chemistry and Informatics Curriculum for Undergraduate and Graduate Students in the Czech Republic

Author

Jirat, Jiri, Cech, Petr, Znamenacek, Jiri, Simek, Miroslav, Skuta, Ctibor, Vanek, Tomas, Dibuszova, Eva, Nic, Miloslav, and Svozil, Daniel

Abstract

Experience developing multidisciplinary bachelor's and master's curricula involving intertwined chemistry, informatics, and librarianship-editorship skills is described. The bachelor's curriculum was created in close cooperation of academic staff, library staff, and the publishing house staff (Institute of Chemical Technology Prague: a sole publisher of chemical literature in Czech Republic), with the aim to educate a new generation of information retrieval and e-publishing professionals in the science-technology-medicine (STM) field. This cooperation together with a set of specifically tailored courses gave students the insights into real-world issues of STM publishing. The master's curriculum, heavily relying on the bachelor's stage, inclines towards cheminformatics and deepens software engineering skills. Successes, pitfalls, and failures are described, together with proposed changes and future directions. (Contains 2 tables.)

Published
2013
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