49 results on '"Vanparys, Philippe"'
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2. A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment
3. Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test
4. Application of in vitro cell transformation assays in regulatory toxicology for pharmaceuticals, chemicals, food products and cosmetics
5. ECVAM prevalidation study on in vitro cell transformation assays: General outline and conclusions of the study
6. Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me 2N-BAVAH, a hydroxamate-based HDAC-inhibitor
7. A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins
8. Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay
9. Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop
10. Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity
11. Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells
12. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
13. Regulatory assessment of in vitro skin corrosion and irritation data within the European framework: Workshop recommendations
14. Evaluation of the Embryotoxic Potency of Compounds in a Newly Revised High Throughput Embryonic Stem Cell Test
15. ECVAM retrospective validation of in vitro micronucleus test (MNT)
16. The in vivo gut micronucleus test detects clastogens and aneugens given by gavage
17. In silicotools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence
18. A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment.
19. An Adult Stem Cell Proliferation Assay in the Flatworm Model Macrostomum lignano to Predict the Carcinogenicity of Compounds
20. “Open Source”–Based Engineered Human Tissue Models: A New Gold Standard for Nonanimal Testing Through Openness, Transparency, and Collaboration, Promoted by the ALEXANDRA Association
21. Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop
22. A 96-well flow cytometric screening assay for detecting in vitro phospholipidosis-induction in the drug discovery phase
23. In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.
24. Preface
25. Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor
26. ECVAM prevalidation of three cell transformation assays
27. A Review of the Implementation of the Embryonic Stem Cell Test (EST)
28. State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish
29. The Practical Application of Three Validated In Vitro Embryotoxicity Tests
30. 3.7. Genotoxicity and Mutagenicity
31. 3.3. Eye Irritation
32. 3.10. Carcinogenicity
33. Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling
34. Interlaboratory validation of a CD71-based flow cytometric method (Microflow®) for the scoring of micronucleated reticulocytes in mouse peripheral blood
35. ECVAM and Pharmaceuticals
36. Flow cytometric enumeration of micronucleated reticulocytes: High transferability among 14 laboratories
37. The Principles of Good Laboratory Practice: Application to In Vitro Toxicology Studies
38. Sampling times in micronucleus testing
39. The micronucleus assay as a test for the detection of aneugenic activity
40. The Practical Application of Three Validated In VitroEmbryotoxicity Tests: The Report and Recommendations of an ECVAM/ZEBET Workshop (ECVAM Workshop 57)1
41. Interlaboratory validation of a CD71‐based flow cytometric method (Microflow®) for the scoring of micronucleated reticulocytes in mouse peripheral blood
42. The Principles of Good Laboratory Practice: Application to In VitroToxicology Studies: The Report and Recommendations of ECVAM Workshop 371,2
43. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing
44. Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor
45. Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.
46. International prevalidation study on cell transformation assay. Preface.
47. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.
48. Carcinogenicity.
49. Eye irritation.
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