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Ground-based and airborne instrumentation for astronomy IX (2022), Montreal, JUL 17-22, 2022.--Proceedings of SPIE - The International Society for Optical Engineering vol. 12184 Article number 1218424.-- Complete list of authors: Marconi, A.; Abreu, M.; Adibekyan, V.; Alberti, V.; Albrecht, S.; Alcaniz, J.; Aliverti, M.; Allende Prieto, C.; Gomez, J. D. Alvarado; Amado, P. J.; Amate, M.; Andersen, M. I.; Artigau, E.; Baker, C.; Baldini, V.; Balestra, A.; Barnes, S. A.; Baron, F.; Barros, S. C. C.; Bauer, S. M.; Beaulieu, M.; Bellido-Tirado, O.; Benneke, B.; Bensby, T.; Bergin, E. A.; Biazzo, K.; Bik, A.; Birkby, J. L.; Blind, N.; Boisse, I.; Bolmont, E.; Bonaglia, M.; Bonfils, X.; Borsa, F.; Brandeker, A.; Brandner, W.; Broeg, C. H.; Brogi, M.; Brousseau, D.; Brucalassi, A.; Brynnel, J.; Buchhave, L. A.; Buscher, D. F.; Cabral, A.; Calderone, G.; Calvo-Ortega, R.; Cantalloube, F.; Canto Martins, B. L.; Carbonaro, L.; Chauvin, G.; Chazelas, B.; Cheffot, A. -L.; Cheng, Y. S.; Chiavassa, A.; Christensen, L.; Cirami, R.; Cook, N. J.; Cooke, R. J.; Coretti, I.; Covino, S.; Cowan, N.; Cresci, G.; Cristiani, S.; Cunha Parro, V.; Cupani, G.; D'Odorico, V.; de Castro Leao, I.; De Cia, A.; De Medeiros, J. R.; Debras, F.; Debus, M.; Demangeon, O.; Dessauges-Zavadsky, M.; Di Marcantonio, P.; Dionies, F.; Doyon, R.; Dunn, J.; Ehrenreich, D.; Faria, J. P.; Feruglio, C.; Fisher, M.; Fontana, A.; Fumagalli, M.; Fusco, T.; Fynbo, J.; Gabella, O.; Gaessler, W.; Gallo, E.; Gao, X.; Genolet, L.; Genoni, M.; Giacobbe, P.; Giro, E.; Goncalves, R. S.; Gonzalez, O. A.; Gonzalez Hernandez, J. I.; Gracia Temich, F.; Haehnelt, M. G.; Haniff, C.; Hatzes, A.; Helled, R.; Hoeijmakers, H. J.; Huke, P.; Jaervinen, A. S.; Jaervinen, S. P.; Kaminski, A.; Korn, A. J.; Kouach, D.; Kowzan, G.; Kreidberg, L.; Landoni, M.; Lanotte, A.; Lavail, A.; Li, J.; Liske, J.; Lovis, C.; Lucatello, S.; Lunney, D.; MacIntosh, M. J.; Madhusudhan, N.; Magrini, L.; Maiolino, R.; Malo, L.; Man, A. W. S.; Marquart, T.; Marques, E. L.; Martins, C. J. A. P.; Martins, A. M.; Maslowski, P.; Mason, E.; Mason, C. A.; McCracken, R. A.; Mergo, P.; Micela, G.; Mitchell, T.; Molliere, P.; Monteiro, M. A.; Montgomery, D.; Mordasini, C.; Morin, J.; Mucciarelli, A.; Murphy, M. T.; N'Diaye, M.; Neichel, B.; Niedzielski, A. T.; Niemczura, E.; Nortmann, L.; Noterdaeme, P.; Nunes, N. J.; Oggioni, L.; Oliva, E.; Onel, H.; Origlia, L.; Ostlin, G.; Palle, E.; Papaderos, P.; Pariani, G.; Penate Castro, J.; Pepe, F.; Levasseur, L. Perreault; Petit, P.; Pino, L.; Piqueras, J.; Pollo, A.; Poppenhaeger, K.; Quirrenbach, A.; Rauscher, E.; Rebolo, R.; Redaelli, E. M. A.; Reffert, S.; Reid, D. T.; Reiners, A.; Richter, P.; Riva, M.; Rivoire, S.; Rodriguez-Lopez, C.; Roederer, I. U.; Romano, D.; Rousseau, S.; Rowe, J.; Salvadori, S.; Sanna, N.; Santos, N. C.; Diaz, P. Santos; Sanz-Forcada, J.; Sarajlic, M.; Sauvage, J. -F.; Schaefer, S.; Schiavon, R. P.; Schmidt, T. M.; Selmi, C.; Sivanandam, S.; Sordet, M.; Sordo, R.; Sortino, F.; Sosnowska, D.; Sousa, S. G.; Stempels, E.; Strassmeier, K. G.; Suarez Mascareno, A.; Sulich, A.; Sun, X.; Tanvir, N. R.; Tenegi-Sangines, F.; Thibault, S.; Thompson, S. J.; Tozzi, A.; Turbet, M.; Vallee, P.; Varas, R.; Venn, K. A.; Veran, J. -P.; Verma, A.; Viel, M.; Wade, G.; Waring, C.; Weber, M.; Weder, J.; Wehbe, B.; Weingrill, J.; Woche, M.; Xompero, M.; Zackrisson, E.; Zanutta, A.; Zapatero Osorio, M. R.; Zechmeister, M.; Zimara, J., The first generation of ELT instruments includes an optical-infrared high resolution spectrograph, indicated as ELT-HIRES and recently christened ANDES (ArmazoNes high Dispersion Echelle Spectrograph). ANDES consists of three fibre-fed spectrographs (UBV, RIZ, YJH) providing a spectral resolution of similar to 100,000 with a minimum simultaneous wavelength coverage of 0.4-1.8 mu m with the goal of extending it to 0.35-2.4 mu m with the addition of a K band spectrograph. It operates both in seeing- and diffraction-limited conditions and the fibre-feeding allows several, interchangeable observing modes including a single conjugated adaptive optics module and a small diffraction-limited integral field unit in the NIR. Its modularity will ensure that ANDES can be placed entirely on the ELT Nasmyth platform, if enough mass and volume is available, or partly in the Coude room. ANDES has a wide range of groundbreaking science cases spanning nearly all areas of research in astrophysics and even fundamental physics. Among the top science cases there are the detection of biosignatures from exoplanet atmospheres, finding the fingerprints of the first generation of stars, tests on the stability of Nature's fundamental couplings, and the direct detection of the cosmic acceleration. The ANDES project is carried forward by a large international consortium, composed of 35 Institutes from 13 countries, forming a team of more than 200 scientists and engineers which represent the majority of the scientific and technical expertise in the field among ESO member states., The Italian effort for ANDES is supported by the Italian National Institute for Astrophysics (INAF). The Portuguese participation is supported by FCT -Fundacao para a Ciencia e a Tecnologia through national funds and by FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao by these grants: UID/FIS/04434/2019, UIDB/04434/2020 & UIDP/04434/2020; POCI-01-0145-FEDER-032113 & PTDC/FIS-AST/32113/2017. Swedish participation in the ANDES project is made possible through the national Swedish ELT Instrumentation Consortium (SELTIC), suppored by the Swedish Research Council (VR). CJM acknowledges FCT and POCH/FSE (EC) support through Investigador FCT Contract 2021.01214.CEECIND/CP1658/CT0001. JLB acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 805445. MTM acknowledges the support of the Australian Research Council through Future Fellowship grant FT180100194 SS acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 804240. TMS acknowledgment the support from the SNF synergia grant CRSII5-193689 (BLUVES), With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709

International audience; Hundreds of fossil marine vertebrates cropping out at Cerro Colorado (Pisco Basin, Peru) are identified and reported on a 1:6500 scale geological map and in a joined stratigraphic section. All the fossils are from the lower strata of the Pisco Formation, dated in this area to the late middle or early late Miocene. They are particularly concentrated (88%) in the stratigraphic interval from 40 to 75 m above the unconformity with the underlying Chilcatay Formation. The impressive fossil assemblage includes more than 300 specimens preserved as bone elements belonging mostly to cetaceans (81%), represented by mysticetes (cetotheriids and balaenopteroids) and odontocetes (kentriodontid-like delphinidans, pontoporiids, ziphiids, and physeteroids, including the giant raptorial sperm whale Livyatan melvillei). Seals, crocodiles, sea turtles, seabirds, bony fish, and sharks are also reported. Isolated large teeth of Carcharocles and Cosmopolitodus are common throughout the investigated stratigraphical interval, whereas other shark teeth, mostly of carcharinids, are concentrated in one sandy interval. This work represents a first detailed census of the extraordinary paleontological heritage of the Pisco Basin and the basis for future taphonomic, paleoecological, and systematic studies, as well as a much needed conservation effort for this extremely rich paleontological site.

Easter Island has experienced a marked increase in tourism during the past few decades; this has intensified the use of natural resources, which has in turn posed new threats to marine wildlife. To gather information on marine turtle species inhabiting Ea

Objective: To explore opinions and perceptions of Practice Change Facilitator of their training and experiences in assisting in the implementation of Medication Reviews with follow- up in Spanish community pharmacy. Methods: A focus group of six Practice Change Facilitators was conducted at the headquarters of the Spanish General Council of Pharmacists' Associations. A semi-structured interview guide was used. Results: Two domains emerged underpinned by a number of themes. One domain was related to the interaction between the pharmacy and the Practice Change Facilitator. This included their role as a motivator, a facilitator of internal and external communication, and teacher of the clinical aspects and methodological issues of the process of medication reviews with a follow-up. The second domain was composed of themes including personal traits and characteristics, and by work-related conditions such as flexibility of the individual and contractual obligations. Conclusions: This paper provides qualitative evidence which can be used by employers to further define the role, functions and optimal personal traits of Practice Change Facilitators.

Introduction: Prior to undertaking a main study, "conSIGUE" 60 pharmacies participated in two pre-pilot phases (Murcia y Granada) and one pilot (Cádiz). Objectives: To explore the experiences and perception of participating pharmacists when undertaking medication review with follow-up. Methods: Focus groups were used as the qualitative technique. All the meetings took place at the three Professional Association headquarters and were conducted by the same researchers. The groups were tape-recorded with a content analysis was performed NVivo®. Results: Eight focus groups were completed. Lack of time, f human resources and the lack of clinical education and skills to do pharmaceutical interventions were identified as the major barriers. Medication review with follow-up was seen to improve the internal organization of the pharmacy, the relationship among members of the staff, the knowledge and use of Bot-plus (a drug information program). The service helped to overcome the fear of physicians and modified the relationship with patients. It also produced a great level of personal satisfaction for the pharmacists. The mentoring programme was assessed very positively. Conclusions: The use of a mentoring element, through the professional college facilitator, to the program appeared to be very important in the initiation and sustainability of the service as it assists to practically solve individualised problems faced by specific pharmacists. ©2011 Ediciones Mayo, S.A. Todos los derechos reservados.

Introducción: La lectura crítica de textos clásicos y modernos a cargo de un tutor docente es una práctica docente validada en la formación de postgrado de psiquiatría. Su inicio data desde hace dos siglos. Existen experiencias registradas en docencia en distintos centros formadores de psiquiatría en la literatura internacional. Método Docente: El departamento de psiquiatría ha establecido un horario en el curriculum de postgrado para lecturas críticas de textos. El grupo de 6 a 8 becados está a cargo de un profesor de psiquiatría. La duración es de 60 minutos aproximado. Se analizan 2 años de estudio restrospectivo con más de 70 horas. Resultados: Discusiones abiertas y docencia en grupos pequeños. Lectura de textos de psiquiatría clásica en español y traducción de textos alemanes. Dos presentaciones de pacientes con tema afín. Conclusiones: La lectura crítica permite un intercambio de opiniones, preguntas abiertas al tutor, estudio de casos clínicos de diagnóstico difícil y de interés psicopatológico. El conocimiento de los textos clásicos permite un análisis crítico de los textos modernos

Introducción: La lectura crítica de textos clásicos y modernos a cargo de un tutor docente es una práctica docente validada en la formación de postgrado de psiquiatría. Su inicio data desde hace dos siglos. Existen experiencias registradas en docencia en distintos centros formadores de psiquiatría en la literatura internacional. Método Docente: El departamento de psiquiatría ha establecido un horario en el curriculum de postgrado para lecturas críticas de textos. El grupo de 6 a 8 becados está a cargo de un profesor de psiquiatría. La duración es de 60 minutos aproximado. Se analizan 2 años de estudio restrospectivo con más de 70 horas. Resultados: Discusiones abiertas y docencia en grupos pequeños. Lectura de textos de psiquiatría clásica en español y traducción de textos alemanes. Dos presentaciones de pacientes con tema afín. Conclusiones: La lectura crítica permite un intercambio de opiniones, preguntas abiertas al tutor, estudio de casos clínicos de diagnóstico difícil y de interés psicopatológico. El conocimiento de los textos clásicos permite un análisis crítico de los textos modernos Introduction: Supervised critical reading of classic psychiatric texts and modern papers is a valida ted educa tional practice in postgradua te studies in psychia try dating back to two cen turies. There are experiences reported in international literature, in different psychiatry teaching centres. Material and Methods: Our department of psychiatry has included critical reading in its educational schedule. The reading time is sixty minutes, and our analysis includes 70 hours of reading. Results: Open discussion and teaching in small groups has been conducted, relating Spanish texts, and German texts translated to Spanish, with the analysis of patients attending our department. Conclusions: Critical reading allows discussion with the tutor, questioning, and the study of difficult cases, with psychopathological interest. Reading classic texts allows critical reading of modern literature

The carotid body's physiological role is to sense arterial oxygen, CO(2) and pH. It is however, also powerfully excited by inhibitors of oxidative phosphorylation. This latter observation is the cornerstone of the mitochondrial hypothesis which proposes that oxygen is sensed through changes in energy metabolism. All of these stimuli act in a similar manner, i.e. by inhibiting a background TASK-like potassium channel (K(B)) they induce membrane depolarization and thus neurosecretion. In this study we have evaluated the role of ATP in modulating K(B) channels. We find that K(B) channels are strongly activated by MgATP (but not ATP(4)(-)) within the physiological range (K(1/2) = 2.3 mm). This effect was mimicked by other Mg-nucleotides including GTP, UTP, AMP-PCP and ATP-gamma-S, but not by PP(i) or AMP, suggesting that channel activity is regulated by a Mg-nucleotide sensor. Channel activation by MgATP was not antagonized by either 1 mm AMP or 500 microm ADP. Thus MgATP is probably the principal nucleotide regulating channel activity in the intact cell. We therefore investigated the effects of metabolic inhibition upon both [Mg(2+)](i), as an index of MgATP depletion, and channel activity in cell-attached patches. The extent of increase in [Mg(2+)](i) (and thus MgATP depletion) in response to inhibition of oxidative phosphorylation were consistent with a decline in [MgATP](i) playing a prominent role in mediating inhibition of K(B) channel activity, and the response of arterial chemoreceptors to metabolic compromise.

Presentamos nuestra experiencia de 6 pacientes con metrorragia a repetición, portadoras de patologías médicas que representaban un riesgo desde el punto de vista anestésico y quirúrgico, en las cuales se insertó DIU-LNG como alternativa a la histerectomía. Todas evolucionan satisfactoriamente y sin complicaciones, con disminución significativa de las pérdidas hemáticas desde el tercer mes de uso, objetivadas por pictogramas. Se concluye que el DIU-LNG es un excelente método para el control de metrorragias en pacientes con patologías médicas relevantes We present our experience with 6 patients with menorrhagia and medical conditions considered high risk patients for anaesthesia and surgical procedures. We inserted LNG-IUD as alternative to hysterectomy. Three months later, all of them reduced menstrual blood loss as it was shown by pictorial charts, without complications. LNG-IUD is an excellent alternative to hysterectomy in this group of patients