Search

Your search keyword '"Varela, Lourdes"' showing total 229 results
Start Over Author "Varela, Lourdes"
229 results on '"Varela, Lourdes"'

3. Supplementary material: Changes in adhesion and the expression of adhesion molecules in PBMCs after Aneurysmal Subarachnoid Hemorrhage: relation to cerebral vasospasm

Author

Varela, Lourdes [0000-0002-8875-6042], Castellano, Antonio [0000-0003-3955-5137], Castellano, Antonio [acastell@us.es], González-Montelongo, María del Carmen [mcarmen.gonzalez@inibica.es], Revilla-González, Gonzalo, Varela, Lourdes, Ruiz de Azúa-López, Zaida, Amaya-Villar, Rosario, Pezzotti, María Rosa, Castro, María José, Ureña, Juan, González-Montelongo, María del Carmen, Castellano, Antonio, Varela, Lourdes [0000-0002-8875-6042], Castellano, Antonio [0000-0003-3955-5137], Castellano, Antonio [acastell@us.es], González-Montelongo, María del Carmen [mcarmen.gonzalez@inibica.es], Revilla-González, Gonzalo, Varela, Lourdes, Ruiz de Azúa-López, Zaida, Amaya-Villar, Rosario, Pezzotti, María Rosa, Castro, María José, Ureña, Juan, González-Montelongo, María del Carmen, and Castellano, Antonio

Abstract

Supplemental Table 1. Statistical analysis of the expression of surface adhesion molecules in circulating and adherent lymphocytes and monocytes. n= 20 control subjects and 21 patients. *, **, *** P≤ 0.05, 0.01, 0.001., Supplemental Figure 1. Gating strategy for the immunocharacterization of PBMCs. (A) Identification of the cells of interest performed by SSC-A and FSC-A. (B) Singlets filter by FSC-A and FSC-H. (C) Alive cells by exclusion of 7-AAD. (D) Identification of PBMCs by SSC-A and expression of CD45. (E) Identification of lymphocytes and monocytes by SSC-A and expression of CD11b. (F) Identification of lymphocyte subpopulations by expression of CD3 and CD19., Supplemental Figure 2. Expression of surface adhesion molecules in circulating and adhered T lymphocytes and monocytes (these data are the same that are shown on Figure 4 of the manuscript, but shown patient by patient). Only statistically significant changes in the adhesion molecules are presented. Comparisons between experiments from the same patients were assessed by paired t test (* P≤ 0.05 vs. control; #P≤ 0.05 vs. P24h).

Published
2024

6. Changes in Adhesion and the Expression of Adhesion Molecules in PBMCs after Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Vasospasm

Author

Universidad de Sevilla, Consorcio de Bibliotecas Universitarias de Andalucía, Ministerio de Economía, Industria y Competitividad (España), European Commission, Revilla-González, Gonzalo, Varela, Lourdes, Ruiz de Azúa-López, Zaida, Amaya-Villar, Rosario, Pezzotti, María Rosa, Castro, María José, Ureña, Juan, González-Montelongo, María del Carmen, Castellano, Antonio, Universidad de Sevilla, Consorcio de Bibliotecas Universitarias de Andalucía, Ministerio de Economía, Industria y Competitividad (España), European Commission, Revilla-González, Gonzalo, Varela, Lourdes, Ruiz de Azúa-López, Zaida, Amaya-Villar, Rosario, Pezzotti, María Rosa, Castro, María José, Ureña, Juan, González-Montelongo, María del Carmen, and Castellano, Antonio

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid space after rupture of the cerebral vessels. After bleeding, the immune response is activated. The role of peripheral blood mononuclear cells (PBMCs) in this response is a current subject of research. We have analysed the changes in PBMCs of patients with aSAH and their interaction with the endothelium, focusing on their adhesion and the expression of adhesion molecules. Using an in vitro adhesion assay, we observed that the adhesion of PBMCs of patients with aSAH is increased. Flow cytometry analysis shows that monocytes increased significantly in patients, especially in those who developed vasospasm (VSP). In aSAH patients, the expression of CD162, CD49d, CD62L and CD11a in T lymphocytes and of CD62L in monocytes increased. However, the expression of CD162, CD43, and CD11a decreased in monocytes. Furthermore, monocytes from patients who developed arteriographic VSP had lower expression of CD62L. In conclusion, our results confirm that after aSAH, monocyte count and adhesion of PBMCs increase, especially in patients with VSP, and that the expression of several adhesion molecules is altered. These observations can help predict VSP and to improve the treatment of this pathology.

Published
2024

7. Impact of Early- and High-Dose Caffeine on the Cerebellum Development in Newborn Rats.

Author

Lemus-Varela, Lourdes, Torres-Mendoza, Blanca, Rabago-Domingo, Paola, Cárdenas-Bedoya, Jhonathan, Zúñiga-González, Guillermo M., Torres-Sanchez, Erandis D., and Gabriel-Ortiz, Genaro

Subjects
*CEREBELLAR cortex, *PREMATURE infants, *BRONCHOPULMONARY dysplasia, *PURKINJE cells, *OXYGEN therapy
Abstract

Introduction: Preterm newborns struggle with maintaining an adequate respiratory pattern; early caffeine administration is suggested to stimulate respiration and reduce bronchopulmonary dysplasia, however, its consequences on the immature cerebellum remains unknown. This study aimed to assess the impact of early caffeine administration, at standard and high doses, accompanied by supplemental oxygen on cerebellar development in an experimental model. Methods: Five groups of Wistar pups were formed (n = 8 offspring/group): (a) negative control: no intervention; (b) placebo: pups remaining from birth until the 7th day of life (DOL) exposed to fractional inspired oxygen (FiO2) 45%, resembling preterm infant condition and as a placebo, 0.2 mL oral 5% dextrose, from the first DOL until the 14th DOL; (c) caffeine group: oral caffeine, 1st DOL 20 mg/kg, and from 2nd to 14th DOL, 5 mg/kg (standard dose); (d) caffeine at the standard dose, plus O2: during the first 7 DOLs (FiO2: 45%); (e) caffeine: 40 mg/kg in the first DOL, 10 mg/kg the next 14 DOLs, plus O2 in the first 7 DOLs (FiO2: 45%). Subjects were sacrificed on their 15th DOL; measurements were taken from the cerebellum, specifically the external granular layer (EGL) and molecular layer (ML), with quantification of cell migration. Results: Caffeine administration in pups resulted in a delay in cerebellum development based on persistent transitional EGL cells; this finding was exacerbated in groups exposed to caffeine plus O2, as evident from the thicker EGL. The negative control group showed near-complete cell migration with a thicker ML and a significantly smaller EGL. Conclusions: Early caffeine administration in newborn rats disrupts cerebellar cortex cell processes and connectivity pathways, with exacerbated effects in groups receiving caffeine plus O2. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis

Author

Álvarez-Amor, Leticia, Sierra, Amparo Luque, Cárdenas, Antonio, López-Bermudo, Lucía, López-Beas, Javier, Andújar, Eloísa, Pérez-Alegre, Mónica, Gallego-Durán, Rocío, Varela, Lourdes M., Martin-Montalvo, Alejandro, Berná, Genoveva, Rojas, Anabel, Robles-Frías, Mª José, Hmadcha, Abdelkrim, Romero-Gómez, Manuel, Kleemann, Robert, and Martín, Franz

Published
2021
Full Text
View/download PDF

9. Oleic acid—the main component of olive oil on postprandial metabolic processes

Author

Lopez, Sergio, primary, Bermudez, Beatriz, additional, Montserrat-de la Paz, Sergio, additional, Pacheco, Yolanda M., additional, Ortega-Gomez, Almudena, additional, Varela, Lourdes M., additional, Lemus-Conejo, Ana, additional, Millan-Linares, Maria C., additional, Rosillo, Maria A., additional, Abia, Rocio, additional, and Muriana, Francisco J.G., additional

Published
2021
Full Text
View/download PDF

10. List of contributors

Author

Abia, Rocio, primary, Abouloifa, H., additional, Adriana, Morales-Martínez, additional, Aggarwal, Diwakar, additional, Aggarwal, Vaishali, additional, Alicia, Sánchez-Mendoza, additional, Andreadou, Ioanna, additional, Angeles-Lo´pez, Quetzalli D., additional, Argüelles, Sandro, additional, Asehraou, A., additional, Audi, Namaa, additional, Ayala, Antonio, additional, Ayoub, Nehad M., additional, Badiu, Diana, additional, Badria, Farid A., additional, Barbouti, Alexandra, additional, Batanero, Eva, additional, Batarseh, Yazan S., additional, Baumann, Leslie S., additional, Ben Salah, R., additional, Bermudez, Beatriz, additional, Blanco, Santos, additional, Borras-Linares, Isabel, additional, Brasca, M., additional, Brenes, Manuel, additional, Perez-Calabuig, Ana M., additional, Cancilla, John C., additional, Cano, Mercedes, additional, Carbone, Fabrizio, additional, Carrera-González, María Pilar, additional, Casas, Rosa, additional, Ceccanti, Mauro, additional, Chaldakov, George N., additional, Covas, María-Isabel, additional, Culeddu, Nicola, additional, Cumaoğlu, Ahmet, additional, Curiel, José Antonio, additional, Damiano, Fabrizio, additional, de Castro, Antonio, additional, de Felipe, Félix López, additional, de la Torre, Rafael, additional, de las Rivas, Blanca, additional, Deiana, Pierfrancesco, additional, Dekanski, Dragana, additional, Dettori, Sandro, additional, Di Stefano, Vita, additional, Domínguez-Vías, German, additional, Dore, Antonio, additional, D’hallewin, G., additional, El Sayed, Khalid A., additional, Elgazar, Abdullah A., additional, Emanuelli, Tatiana, additional, Ferraguti, Giampiero, additional, Filigheddu, Maria Rosaria, additional, Fiore, Marco, additional, Fitó, Montserrat, additional, Francisca, Pérez-Severiano, additional, Fujiwara, Yoko, additional, Galaris, Dimitrios, additional, García, Pedro, additional, Ghabbour, N., additional, Giudetti, Anna Maria, additional, Gnoni, Antonio, additional, Gnoni, Gabriele Vincenzo, additional, Goulas, Vlasios, additional, Greco, Antonio, additional, Guclu, Gamze, additional, Haghbeen, Kamahldin, additional, Handjani, Farhad, additional, Heydari, Mojtaba, additional, Hosseini Mazinani, Mehdi, additional, Ishikawa, Tomoko, additional, Iuliano, Luigi, additional, Joel, Jiménez-Gómez, additional, Joshi, Asavari, additional, Juan, M. Emília, additional, Jugreet, Bibi Sharmeen, additional, Kaddoumi, Amal, additional, Kailis, Stanley George, additional, Kanavaros, Panagiotis, additional, Karboune, S., additional, Kelebek, Hasim, additional, Kitsoulis, Panagiotis, additional, Kouka, Paraskevi, additional, Kouretas, Demetrios, additional, Ktari, N., additional, Kumar, Gaurav, additional, Kumar, Manoj, additional, Landete, José María, additional, Lauretti, Elisabetta, additional, Lemus-Conejo, Ana, additional, Lombardo, Luca, additional, Longo, Serena, additional, Pradana-Lopez, Sandra, additional, Lopez, Sergio, additional, Lopez-Millan, Belen, additional, López-López, Antonio, additional, Lozano-Sánchez, Jesús, additional, Madar, Zecharia, additional, Mahomoodally, Mohamad Fawzi, additional, Mañas, Mariano, additional, Martinez-Victoria, Emilio, additional, Martinez-Burgos, Maria Alba, additional, Martínez-Martos, José Manuel, additional, Masre, Siti Fathiah, additional, Medina, Eduardo, additional, Medina, Rafael, additional, Menendez, Javier A., additional, Millan-Linares, Maria C., additional, Mittal, Sonam, additional, Mohammadnejad, Parvin, additional, Molinu, Maria Giovanna, additional, Montaño, Alfredo, additional, Montserrat-de la Paz, Sergio, additional, Muñoz, Mario, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Nenadis, N., additional, Nychas, G.-J.E., additional, Ortega-García, Francisca, additional, Ortega-Gomez, Almudena, additional, Pacheco, Yolanda M., additional, Panagou, E.Z., additional, Papoti, V.T., additional, Pariente, Jose Antonio, additional, Parvizi, Mohammad Mahdi, additional, Pathak, Kaveri, additional, Peinado, M. Ángeles, additional, Peragón, Juan, additional, Petrella, Carla, additional, Čabarkapa-Pirkovic, Andrea, additional, Planas, Joana M., additional, Plastina, Pierluigi, additional, Praticò, Domenico, additional, Prieto, Isabel, additional, Rajendram, Rajkumar, additional, Ralli, Massimo, additional, Ramírez-Expósito, María Jesús, additional, Ramírez-Sánchez, Manuel, additional, Rasouli, Hassan, additional, Al Rihani, Sweilem B., additional, Rodríguez, Héctor, additional, Rodríguez-López, Paloma, additional, Rokni, Y., additional, Romero, Concepción, additional, Rosillo, Maria A., additional, Ruiz-Barba, José Luis, additional, Saalaoui, E., additional, Sacanella, Emilio, additional, Sadeer, Nabeelah Bibi, additional, Sak, Katrin, additional, Saki, Maryam, additional, Salimonti, Amelia, additional, Sánchez, Antonio-Higinio, additional, Santona, Mario, additional, Segarra, Ana Belén, additional, Segura-Carretero, Antonio, additional, Selli, Serkan, additional, Sergio, Montes, additional, Sethi, Gautam, additional, Seyedebrahimi, Seyede Sanaz, additional, Shahbaz, Mana, additional, Sharma, Dhvani, additional, Soares, Mario J, additional, Spremo-Potparević, Biljana, additional, Stark, Aliza Hannah, additional, Suroowan, Shanoo, additional, Suvarna, Vasanti, additional, Tahiri, Iasim, additional, Tarani, Luigi, additional, Tassou, C.C., additional, Topalović, Dijana, additional, Torrecilla, José S., additional, Tseti, Ioulia, additional, Tsimidou, M.Z., additional, Tsoumani, Maria, additional, Tuli, Hardeep Singh, additional, Varela, Lourdes M., additional, Veskoukis, Aristidis S., additional, Villalba, Mayte, additional, Weisberg, Edmund M., additional, Yago, Maria Dolores, additional, Yang, Euitaek, additional, Yerer, Mükerrem Betül, additional, Zanwar, Anand, additional, Zelasco, Samanta, additional, and Živković, Lada, additional

Published
2021
Full Text
View/download PDF

13. HDL anti-inflammatory function is impaired and associated with high SAA1 and low APOA4 levels in aneurysmal subarachnoid hemorrhage

Author

Ambassade de France en Espagne, Junta de Andalucía, European Commission, Universidad de Sevilla, Ruiz de Azúa-López, Zaida, Pezzotti, María R., González-Díaz, Ángela, Meilhac, Olivier, Ureña, Juan, Amaya-Villar, Rosario, Castellano, Antonio, Varela, Lourdes, Ambassade de France en Espagne, Junta de Andalucía, European Commission, Universidad de Sevilla, Ruiz de Azúa-López, Zaida, Pezzotti, María R., González-Díaz, Ángela, Meilhac, Olivier, Ureña, Juan, Amaya-Villar, Rosario, Castellano, Antonio, and Varela, Lourdes

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease with high morbidity and mortality rates. Within 24 hours after aSAH, monocytes are recruited and enter the subarachnoid space, where they mature into macrophages, increasing the inflammatory response and contributing, along with other factors, to delayed neurological dysfunction and poor outcomes. High-density lipoproteins (HDL) are lipid-protein complexes that exert anti-inflammatory effects but under pathological conditions undergo structural alterations that have been associated with loss of functionality. Plasma HDL were isolated from patients with aSAH and analyzed for their anti-inflammatory activity and protein composition. HDL isolated from patients lost the ability to prevent VCAM-1 expression in endothelial cells (HUVEC) and subsequent adhesion of THP-1 monocytes to the endothelium. Proteomic analysis showed that HDL particles from patients had an altered composition compared to those of healthy subjects. We confirmed by western blot that low levels of apolipoprotein A4 (APOA4) and high of serum amyloid A1 (SAA1) in HDL were associated with the lack of anti-inflammatory function observed in aSAH. Our results indicate that the study of HDL in the pathophysiology of aSAH is needed, and functional HDL supplementation could be considered a novel therapeutic approach to the treatment of the inflammatory response after aSAH.

Published
2023

14. Chapter Nutrigenomics and Atherosclerosis: The Postprandial and Long-Term Effects of Virgin Olive Oil Ingestion

Author

Lopez, Sergio, Abia, Rocio, Muriana, Francisco J.G., Bermudez, Beatriz, Ortega, Almudena, and Varela, Lourdes M.

Subjects
Technology, engineering, agriculture, bic Book Industry Communication::T Technology, engineering, agriculture::TD Industrial chemistry & manufacturing technologies::TDM Metals technology / metallurgy
Abstract

Metals technology / metallurgy

Published
2012
Full Text
View/download PDF

17. Changes in Adhesion and the Expression of Adhesion Molecules in PBMCs after Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Vasospasm

Author

Revilla-González, Gonzalo, primary, Varela, Lourdes María, additional, Ruiz de Azua-López, Zaida, additional, Amaya-Villar, Rosario, additional, Pezzotti, María Rosa, additional, Castro, María José, additional, Ureña, Juan, additional, González-Montelongo, María del Carmen, additional, and Castellano, Antonio, additional

Published
2023
Full Text
View/download PDF

22. New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood

Author

Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Ortega-Gómez, Almudena, López Martín, Sergio, Varela, Lourdes, Jaramillo Carmona, Sara M., Muriana, Francisco J. G., Abia, Rocío, Ministerio de Ciencia e Innovación (España), European Commission, Agencia Estatal de Investigación (España), Ortega-Gómez, Almudena, López Martín, Sergio, Varela, Lourdes, Jaramillo Carmona, Sara M., Muriana, Francisco J. G., and Abia, Rocío

Abstract

Chronic administration of a high-fat diet in mice has been established to influence the generation and trafficking of immune cells such as neutrophils in the bone marrow, the dysregulation of which may contribute to a wide range of diseases. However, no studies have tested the hypothesis that a short-term, high-fat diet could early modulate the neutrophil release from bone marrow at fasting and at postprandial in response to a high-fat meal challenge, and that the predominant type of fatty acids in dietary fats could play a role in both context conditions. Based on these premises, we aimed to establish the effects of different fats [butter, enriched in saturated fatty acids (SFAs), olive oil, enriched in monounsaturated fatty acids (MUFAs), and olive oil supplemented with eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids] on neutrophil navigation from bone marrow to blood in mice. The analysis of cellular models for mechanistic understanding and of postprandial blood samples from healthy volunteers for translational purposes was assessed. The results revealed a powerful effect of dietary SFAs in promotion the neutrophil traffic from bone marrow to blood via the CXCL2-CXCR2 axis. Dietary SFAs, but not MUFAs or EPA and DHA, were also associated with increased neutrophil apoptosis and bone marrow inflammation. Similar dietary fatty-acid-induced postprandial neutrophilia was observed in otherwise healthy humans. Therefore, dietary MUFAs might preserve bone marrow health and proper migration of bone marrow neutrophils early in the course of high-fat diets even after the intake of high-fat meals.

Published
2022

31. High-Density Lipoproteins and Mediterranean Diet: A Systematic Review

Author

Grao-Cruces, Elena, Varela, Lourdes M., Martin, Maria E., Bermudez, Beatriz, Montserrat-de la Paz, Sergio, [Grao-Cruces,E, Montserrat-de la Paz,S] Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain. [Varela,LM] Institute of Biomedicine of Seville, IBiS, Universitary Hospital Virgen del Rocio/CSIC/University of Seville, Seville, Spain. [Varela,LM] Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain. [Martin,ME, Bermudez,B] Department of Cell Biology, Faculty of Biology, University of Seville, Seville, Spain., and This study was supported by the research Grant US-1263458 (Andalusian Ministry of Economy, Knowledge, Business, and University, Government of Andalusia, Spain) into the European Regional Development Fund Operational Programme—2014 to 2020.

Subjects
Health Care::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Secondary Prevention [Medical Subject Headings], Proteome, Revisión sistemática, Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL [Medical Subject Headings], Chemicals and Drugs::Lipids::Lipoproteins [Medical Subject Headings], Lipidome, Lipidómica, Dieta mediterránea, Aceite de oliva, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mediterranean diet, High-density lipoprotein, Lipoproteínas HDL, Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL [Medical Subject Headings], Metaanálisis, Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Olive oil, Proteoma
Abstract

Cardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies in CVD secondary prevention and the lack of association between HDL-C and the risk of CVD. Recent evidences suggest that HDL composition and functionality could be modulated by diet. The purpose of this systematic review was to investigate the effect of Mediterranean diet (MD) on changes in HDL structure and functionality in humans. A comprehensive search was conducted in four databases (PubMed, Scopus, Cochrane library and Web of Science) and 13 records were chosen. MD showed favorable effects on HDL functionality, particularly by improving HDL cholesterol efflux capacity and decreasing HDL oxidation. In addition, HDL composition and size were influenced by MD. Thus, MD is a protective factor against CVD associated with the improvement of HDL quality and the prevention of HDL dysfunctionality. Yes

Published
2021

32. Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant

Author

Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Arana Rueda, Eduardo, Pezzotti, María R., Pedrote, Alonso, Acosta, Juan, Frutos-López, Manuel, Varela, Lourdes M., García-Fernández, Noelia, Castellano Orozco, Antonio Gonzalo, Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica, Arana Rueda, Eduardo, Pezzotti, María R., Pedrote, Alonso, Acosta, Juan, Frutos-López, Manuel, Varela, Lourdes M., García-Fernández, Noelia, and Castellano Orozco, Antonio Gonzalo

Abstract

SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an overlapping phenotype. Functional consequences of SCN5A variants assessed by patch‐clamp electrophysiology are particularly beneficial for correct pathogenic classification and are related to disease penetrance and severity. Here, we identify a novel SCN5A loss of function variant, p.1449Y>H, which presented with high penetrance and complete left bundle branch block, totally masking the typical findings on the electrocardiogram. We highlight the possibility of this overlap combination that makes impossible an electrocardiographic diagnosis and, through a functional analysis, associate the p.1449Y>H variant to SCN5A pathogenicity.

Published
2021

33. C-terminal Motifs of HIV-1 gp41 as Possible Determinants of Viral Pathogenesis

Author

Narváez Pardo, Jorge Andrés, Villarreal Camacho, Jose Luis, Varela, Lourdes, Cervantes Acosta, Guillermo, Narváez Pardo, Jorge Andrés, Villarreal Camacho, Jose Luis, Varela, Lourdes, and Cervantes Acosta, Guillermo

Abstract

Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS), a pandemic with high economic and social costs. The envelope glycoprotein (env) of the virus mediates the infectious process by binding to and entering the host cell, one of the main target components of studies since its discovery. Its endodomain or C-terminal tail (CTT) participates in late replicative cycle processes, such as intracellular trafficking, activation, and cell death, which occurs because it interacts with multiple cellular factors through motifs or signal sequences present throughout its structure. Although these interactions have not been fully understood at specific levels, studies over more than three decades leave no doubt that this domain plays a fundamental role in the biology of the virus and probably the development of the disease. This review describes the studies carried out to date that demonstrate the importance of the CTT, focusing on the motifs responsible for its interactions and its possible roles in the pathogenicity of the infection., O vírus da imunodeficiência humana tipo 1 (HIV-1) é o agente etiológico da síndrome da imunodeficiência adquirida (AUXILIA), uma pandemia com elevados custos económicos e sociais. A glicoproteína do envelope (env) do vírus media o processo infeccioso ligando-se e entrando na célula hospedeira, um dos principais componentes alvo dos estudos desde sua descoberta. Seu endo domínio ou cauda C-terminal (CTT) participa de processos do ciclo replicativo tardio, como tráfego intracelular, ativação e morte celular, que ocorre porque interage com múltiplos fatores celulares por meio de motivos ou sequências-sinal presentes em toda a sua estrutura. Embora essas interações não tenham sido totalmente compreendidas em níveis específicos, estudos ao longo de mais de três décadas não deixam dúvidas de que esse domínio desempenha um papel fundamental na biologia do vírus e provavelmente no desenvolvimento da doença. Esta revisão descreve os estudos realiza- dos até o momento que demonstram a importância da CTT, com foco nos motivos responsáveis por suas interações e seus possíveis papéis na patogenicidade da infecção., El virus de la inmunodeficiencia humana tipo 1 (VIH-1) es el agente etiológico del síndrome de inmunodeficiencia adquirida (SIDA), una pandemia con altos costos económicos y sociales. La glicoproteína de la envoltura (env) del virus media el proceso infeccioso al unirse a la célula huésped y entrar en ella, uno de los principales componentes objetivo de los estudios desde su descubrimiento. Su endodominio o cola C-terminal (CTT) participa en procesos tardíos del ciclo replicativo, como tráfico intracelular, activación y muerte celular, lo que ocurre porque interactúa con múltiples factores celulares a través de motivos o secuencias señal presentes en toda su estructura. Aunque estas interacciones no se han entendido completamente a niveles específicos, los estudios durante más de tres décadas no dejan dudas de que este campo juega un papel fundamental en la biología del virus y probablemente en el desarrollo de la enfermedad. Esta revisión describe los estudios realizados hasta la fecha que demuestran la importancia de la CTT, centrándose en los motivos responsables de sus interacciones y sus posibles roles en la patogenicidad de la infección.

Published
2021

34. Sindrome de Behçet: Enfermedad de la ruta de la seda

Author

Clavijo Tinoco, Fair, Herrera Alvarado, Alcides, Herrera Villalba, Harol, Fernández Franco, Jorge, Díaz Alcendra, Óscar, Varela, Lourdes, Silva, Olivia, Clavijo Tinoco, Fair, Herrera Alvarado, Alcides, Herrera Villalba, Harol, Fernández Franco, Jorge, Díaz Alcendra, Óscar, Varela, Lourdes, and Silva, Olivia

Abstract

Behect`s disease is a variable vessel multysistemic vasculitic inflamatory disorder characterized by recurrent oral, genital, aphtous ulcers, posterior bilateral panuveitis, joint manifestations and occasionally compromiso of the central nervous system and large vessels. The varied clinical mmanifestations and the lack of pathognomonic test make the disease a diagnostic challenge whose prevalence in Colombia is unknown. The diagnosis is bases on diagnostic criterio proposed in absence of a Gold Estandard test. Regarding the etiology, varios theories have been studied incluiding those of inmunological origin especially due to the existence of HLA-B51, followed by those that blame infectious agents,endotelial damage among others. A case is presented, corresponding to a famale patient of 35 years og age with chronic and recurrent symptoms of oral trush, the presence of dermatological lesions and the appearance of genital ulcers is presented. Discarding inmunomediated, infectious and inflammatory causes. Considering a picture of recurrent bipolar aphtosis and faced with dermatológical symptoms, it vas proposes to apply the diagnostic criterio of the International Team for the Revision of the Internacional Criteria for Behcet Disease with a score of 4, which supports the diagnosis of Behcets disease. Management was based on the introduction of therapeutic measures bases on systemic corticosteroids and immunosuppressants, with an adequate clinical reponse., La enfermedad de Behcet es un trastorno inflamatorio multisistémico vasculítico de vaso variable caracterizado por úlceras aftosas orales, genitales, recurrentes, panuveítis bilateral posterior, manifestaciones articulares y ocasionalmente compromiso del sistema nervioso central y grandes vasos . Las variadas manifestaciones clínicas y la falta de pruebas patognomónicas hacen de la enfermedad un reto diagnóstico cuya prevalencia en Colombia se desconoce. El diagnostico se basa en criterios diagnósticos propuestos ante la falta de una prueba Gold Standard. Con relación a la etiología se han estudiado diversas teorías, entre ellas las de origen inmunológico, especialmente por la existencia del HLA - B51, le siguen aquellas que responsabilizan a agentes infecciosos, daño endotelial, entre otros. Se presenta el caso de un paciente femenino de 35 años, con cuadro crónico y recurrente de aftas orales, presencia de lesiones dermatológicas y aparición de ulceras genitales. Descartándose causas inmunomediadas, infecciosas e inflamatorias. Considerándose un cuadro de aftosis bipolar recurrente y ante los síntomas dermatológicos, se propuso aplicar los criterios diagnósticos del International Team for the Revision of International Criteria for Behçet Disease, con una puntuación de 4, lo que avala el diagnostico de enfermedad de Behcet. El manejo se basó en la instauración de medidas terapéuticas a base de corticosteroides sistémicos e inmunosupresores, con adecuada respuesta clínica.

Published
2021

35. Brugada syndrome masked by complete left bundle branch block: A clinical and functional study of its association with the p.1449Y>H SCN5A variant

Author

Arana-Rueda, Eduardo, Pezzotti, María R., Pedrote, Alonso, Acosta, Juan, Frutos‐López, Manuel, Varela, Lourdes, García-Fernández, Noelia, Castellano, Antonio, Arana-Rueda, Eduardo, Pezzotti, María R., Pedrote, Alonso, Acosta, Juan, Frutos‐López, Manuel, Varela, Lourdes, García-Fernández, Noelia, and Castellano, Antonio

Abstract

SCN5A gene variants are associated with both Brugada syndrome and conduction disturbances, sometimes expressing an overlapping phenotype. Functional consequences of SCN5A variants assessed by patch-clamp electrophysiology are particularly beneficial for correct pathogenic classification and are related to disease penetrance and severity. Here, we identify a novel SCN5A loss of function variant, p.1449Y>H, which presented with high penetrance and complete left bundle branch block, totally masking the typical findings on the electrocardiogram. We highlight the possibility of this overlap combination that makes impossible an electrocardiographic diagnosis and, through a functional analysis, associate the p.1449Y>H variant to SCN5A pathogenicity.

Published
2021

36. Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Álvarez-Amor, Leticia, Luque-Sierra, Amparo, Cárdenas-García, Antonio, López-Bermudo, Lucía, López-Beas, Javier, Andújar, Eloísa, Pérez-Alegre, Mónica, Gallego-Durán, Rocío, Varela, Lourdes, Berná, Genoveva, Rojas, Anabel, Robles-Frías, María José, Hmadcha, Abdelkrim, Romero-Gómez, Manuel, Kleemann, Robert, Martín, Franz, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Álvarez-Amor, Leticia, Luque-Sierra, Amparo, Cárdenas-García, Antonio, López-Bermudo, Lucía, López-Beas, Javier, Andújar, Eloísa, Pérez-Alegre, Mónica, Gallego-Durán, Rocío, Varela, Lourdes, Berná, Genoveva, Rojas, Anabel, Robles-Frías, María José, Hmadcha, Abdelkrim, Romero-Gómez, Manuel, Kleemann, Robert, and Martín, Franz

Abstract

Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced NAFLD using Ldlr−/−. Leiden mice. In female Ldlr−/−.Leiden mice, the effects of the following high fat diets (HFDs) were examined: a lard-based HFD (HFD-L); an EVOO-based HFD (HFD-EVOO); a phenolic compounds-rich EVOO HFD (HFD-OL). We studied changes in body weight (BW), lipid profile, transaminases, glucose homeostasis, liver pathology and transcriptome. Both EVOO diets reduced body weight (BW) and improved insulin sensitivity. The EVOOs did not improve transaminase values and increased LDL-cholesterol and liver collagen content. EVOOs and HFD-L groups had comparable liver steatosis. The profibrotic effects were substantiated by an up-regulation of gene transcripts related to glutathione metabolism, chemokine signaling and NF-kappa-B activation and down-regulation of genes relevant for fatty acid metabolism. Collectivelly, EVOO intake improved weight gain and insulin sensitivity but not liver inflammation and fibrosis, which was supported by changes in hepatic genes expression.

Published
2021

39. Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?

Author

Sola, Augusto, Golombek, Sergio G., Montes Bueno, María Teresa, Lemus-Varela, Lourdes, Zuluaga, Claudia, Domínguez, Fernando, Baquero, Hernando, Young Sarmiento, Alejandro E., Natta, Diego, Rodriguez Perez, Jose M., Deulofeut, Richard, Quiroga, Ana, Flores, Gabriel Lara, Morgues, Mónica, Pérez, Alfredo García-Alix, Van Overmeire, Bart, and van Bel, Frank

Published
2014
Full Text
View/download PDF

42. Endocarditis en válvula aórtica nativa por Salmonella serotype Choleraesuis

Author

Andrés Rojas, Camilo, Torregrosa H, Jorge, Varela, Lourdes, Fernández Chica, Dinno, Andrés Rojas, Camilo, Torregrosa H, Jorge, Varela, Lourdes, and Fernández Chica, Dinno

Abstract

Patient with a history of Chronic Myeloid Leukemia (CML) on day 10 postoperatively with respiratory distress and functional class decrease in addition to febrile peaks of 38.9 led to an allogeneic transplant of hematopoietic precursors, on physical examination presence of holosystolic murmur in the base, blood cultures with a positive report of S. choleraesuis 4 of 4, a transesophageal echocardiogram was taken showing vegetation filiform in the aortic valve with 12 mm without ejection fraction compromise and hemodynamic compromise, medical management with quinolones for 4 weeks was decided, achieving disappearance of the vegetation and murmur one week after medical treatment and negative blood cultures later., Se presenta el caso de un paciente con antecedente de Leucemia Mieloide Crónica (LMC) llevado a trasplante alogénico de precursores hematopoyéticos, en el día 10 postoperatorio refiere dificultad respiratoria y empeoramiento de clase funcional además de picos febriles de 38.9, al examen físico presencia de soplo holosistólico en focos de la base, realizan hemocultivos con reporte positivo de S. choleraesuis en 4 de 4, se toma ecocardiograma transesofágico donde se evidencia vegetación en válvula aórtica - valva semilunar posterior (no coronaria) de 12 mm filiforme sin condicionamiento de fracción de eyección -, por estabilidad clínica del paciente sin evidencia de compromiso hemodinámico se decide manejo médico con quinolonas por 4 semanas, logrando desaparición de la vegetación y del soplo a la semana de tratamiento médico y negativización de hemocultivos posteriores.

Published
2020

43. A Lupine (Lupinus angustifolius L.) peptide prevents non-alcoholic fatty liver disease in high-fat diet-induced obese mice

Author

Universidad de Sevilla, Lemus-Conejo, Ana, Grao‐Cruces, Elena, Toscano-Sánchez, Rocío, Varela, Lourdes, Claro, Carmen, Pedroche, Justo, Millán, Francisco, Millán-Linares, María del Carmen, Montserrat-de la Paz, Sergio, Universidad de Sevilla, Lemus-Conejo, Ana, Grao‐Cruces, Elena, Toscano-Sánchez, Rocío, Varela, Lourdes, Claro, Carmen, Pedroche, Justo, Millán, Francisco, Millán-Linares, María del Carmen, and Montserrat-de la Paz, Sergio

Abstract

Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg−1 day−1 or 1 mg kg−1 day−1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways.

Published
2020

46. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. Beatriz P.P., additional, Orihara, Yutaka, additional, Ortega, Almudena, additional, Ortega-García, Francisca, additional, Osada, Jesús, additional, Özdemir, Durmuş, additional, Öztürk, Betül, additional, Pacheco, Yolanda M., additional, Paice, Alistair G., additional, Palmerini, Carlo A., additional, Panagiotakos, Demosthenes, additional, Panagou, E.Z., additional, Panzella, Lucia, additional, Papoti, V.T., additional, Paradiso, Vito Michele, additional, Pariente, José Antonio, additional, Patel, Vinood B., additional, Peinado, M. Ángeles, additional, Pellicanò, Teresa Maria, additional, Peragon, Juan, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Perona, Javier Sanchez, additional, Piperno, Anna, additional, Planas, Joana M., additional, Pollicino, Donatella, additional, Polzonetti, Valeria, additional, Populin, Tiziana, additional, Portillo, Maria P., additional, Pozo, David, additional, Prenzler, Paul, additional, Prieto, Pablo G., additional, Pucciarelli, Stefania, additional, Puel, Caroline, additional, Puertollano, Elena, additional, Puertollano, María A., additional, Quesada-Granados, Jose Javier, additional, Rajendram, Rajkumar, additional, Ramírez-Expósito, María Jesús, additional, Ramos, Sonia, additional, Ramos-Martos, Natividad, additional, Randazzo, Cinzia L., additional, Rando, Rossana, additional, Reiter, Russel J., additional, Rejano, Luis, additional, Rhee, Hae-Ik, additional, Robards, Kevin, additional, Rodriguez, Hector, additional, Rodríguez-Cabezas, Maria Elena, additional, Rodríguez-Manero, Moises, additional, Rodríguez-Méndez, María L., additional, Rodríguez, Rosalía, additional, Rodriguez-Rodriguez, Rosalia, additional, Romani, Annalisa, additional, Romero, Concepción, additional, Romero, Maria-Paz, additional, Romero-Gonzalez, Roberto, additional, Rose, Martin, additional, Rossi, Mauro, additional, Rotondi, Annalisa, additional, Rowland, Ian R., additional, Ruiz, Adolfina, additional, Ruiz-Gutiérrez, Valentina, additional, Russo, Francesco, additional, Ryan, Danielle, additional, Sabatini, Nadia, additional, Sacco, Antonio, additional, Sahan, Yasemin, additional, Saitta, Marcello, additional, Salvador, Maria Desamparados, additional, Samperi, Roberto, additional, Samaniego-Sánchez, Cristina, additional, Sánchez, Antonio Higinio, additional, Sánchez-Navarro, Maria Rosa, additional, Sancho, Verónica, additional, Santos-González, Mónica, additional, Saraiva, Jorge A., additional, Scampicchio, Matteo, additional, Scazzocchio, Beatrice, additional, Schmitt, Christoph A., additional, Schwartz, Betty, additional, Sciuto, Sebastiano, additional, Scoditti, Egeria, additional, Seabra, Rosa M., additional, Sebastiani, Luca, additional, Segre, Anna Laura, additional, Segura, Antonio, additional, Servili, Maurizio, additional, Shiraishi, Ryosuke, additional, Siculella, Luisa, additional, Simão, Andréa Colado, additional, Sindona, Giovanni, additional, Sivakumar, Ganapathy, additional, Skaltsounis, Alexios-Leandros, additional, Smith, Amos B., additional, Spatafora, Carmela, additional, Sperry, Jeffrey B., additional, Soares, Mario J., additional, Soriguer, Federico, additional, Srirajaskanthan, Rajaventhan, additional, Stitia, Naïm, additional, Tabernero, Arantxa, additional, Tagarelli, Antonio, additional, Tai, Fuju, additional, Tamborrino, Antonia, additional, Tassou, C.C., additional, Tesseromatis, Christine, additional, Todeschini, Roberto, additional, Torrecilla, Jose S., additional, Trikib, Saïda, additional, Tringali, Corrado, additional, Tsakiris, Ioannis N., additional, Tsatsakis, Aristidis M., additional, Tsimidou, M.Z., additional, Uccella, Nicola A., additional, Urbano, Francisco J., additional, Valcarcel, Miguel, additional, Valencia-Serrano, Félix, additional, Valentão, Patrícia, additional, Valverde, Isabel, additional, Varela, Lourdes M., additional, Varì, Rosaria, additional, Simas Vaz, Fernando Antonio, additional, Vettorazzi, Ariane, additional, Vichi, Stefania, additional, Vidal, José Luis Martínez, additional, Villalba, José M., additional, Villalba, Mayte, additional, Villanueva-Peñacarrillo, María L., additional, Vincenzetti, Silvia, additional, Vita, Alberto, additional, Vlahov, Giovanna, additional, Wang, Wei, additional, Weisberg, Edmund, additional, Wenzel, Uwe, additional, Won, Se-Ra, additional, Wu, Bin, additional, Yago, María Dolores, additional, Zabaras, Dimitrios, additional, Zappia, Vincenzo, additional, Zarzuelo, Antonio, additional, and Zhang, Luyong, additional

Published
2010
Full Text
View/download PDF

47. Oleic Acid

Author

Lopez, Sergio, primary, Bermudez, Beatriz, additional, Pacheco, Yolanda M., additional, Ortega, Almudena, additional, Varela, Lourdes M., additional, Abia, Rocio, additional, and Muriana, Francisco J.G., additional

Published
2010
Full Text
View/download PDF

50. CCHD Screening Implementation Efforts in Latin American Countries by the Ibero American Society of Neonatology (SIBEN)

Author

Sola, Augusto, primary, Rodríguez, Susana, additional, Young, Alejandro, additional, Lemus Varela, Lourdes, additional, Villamayor, Ramón Mir, additional, Cardetti, Marcelo, additional, Pleitez Navarrete, Jorge, additional, Favareto, María Verónica, additional, Lima, Victoria, additional, Baquero, Hernando, additional, Velandia Forero, Lorena, additional, Venegas, María Elena, additional, Davila, Carmen, additional, Dominguez Dieppa, Fernando, additional, Germosén, Taína Malena, additional, Oviedo Barrantes, Ada Nidia, additional, Alvarez Castañeda, Ana Lorena, additional, Morgues, Mónica, additional, Avila, Aldana, additional, Fariña, Diana, additional, Oliva, Jose Luis, additional, Sosa, Erika, additional, and Golombek, Sergio, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results