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Your search keyword '"Vargas, Juana"' showing total 125 results
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125 results on '"Vargas, Juana"'

1. Cardiac alterations induced by Heloderma horridum horridum venom in rats: An experimental study with ECG analysis using a linear regression algorithm

Author

Vazquez-Gonzalez, Karla Isabel, Ochoa-Brust, Alberto, Rodriguez-Hernandez, Alejandrina, Ventura-Cisneros, Hugo, Lino-Lopez, Gisela Jareth, Barbosa-Valdovinos, Rafael, Rodriguez-Vazquez, Armando, Vazquez-Vuelvas, Oscar F., Felix, Ramon A., Jiménez-Vargas, Juana M., Melnikov, Valery, and Valdez-Velazquez, Laura Leticia

Published
2024
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3. Indolealkylamines in the venom of the scorpion Thorellius intrepidus

Author

Ibarra-Vega, Rodrigo, Jiménez-Vargas, Juana María, Pineda-Contreras, Armando, Martínez-Martínez, Francisco Javier, Barajas-Saucedo, Carlos Eduardo, García-Ortega, Héctor, Magaña-Vergara, Nancy E., Possani, Lourival D., Corzo, Gerardo, Gaitan-Hinojosa, Mario Alberto, Vázquez-Vuelvas, Oscar Fernando, Zamudio, Fernando, and Valdez-Velazquez, Laura Leticia

Published
2023
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5. Proteomic Analysis of Heloderma horridum horridum Venom: Assessment to Its Transcriptome and Newfound Proteins.

Author

Lino-López, Gisela J., Ruiz-May, Eliel, Elizalde-Contreras, José M., Jiménez-Vargas, Juana M., Rodríguez-Vázquez, Armando, González-Carrillo, Gabino, Bojórquez-Velázquez, Esaú, García-Villalvazo, Patricia E., Bermúdez-Guzmán, Manuel de J., Zatarain-Palacios, Rocio, Vázquez-Vuelvas, Oscar F., Valdez-Velázquez, Laura L., and Corzo, Gerardo

Published
2024
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10. Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion Centruroides possanii (Buthidae) through Omic Technologies

Author

García-Villalvazo, Patricia Elizabeth, primary, Jiménez-Vargas, Juana María, additional, Lino-López, Gisela Jareth, additional, Meneses, Erika Patricia, additional, Bermúdez-Guzmán, Manuel de Jesús, additional, Barajas-Saucedo, Carlos Eduardo, additional, Delgado Enciso, Iván, additional, Possani, Lourival Domingos, additional, and Valdez-Velazquez, Laura Leticia, additional

Published
2023
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25. Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus

Author

Alamilla, Javier, primary, Jiménez-Vargas, Juana María, additional, Galván-Hernández, Alan R., additional, Reyes-Méndez, Miriam E., additional, Bermúdez-Gúzman, Manuel J., additional, Restano-Cassulini, Rita, additional, Olamendi-Portugal, Timoteo, additional, Zamudio, Fernando Z., additional, Possani, Lourival D., additional, and Valdez-Velázquez, Laura L., additional

Published
2021
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31. Additional file 3: of Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

Author

Veytia-Bucheli, José, Jiménez-Vargas, Juana, Melchy-Pérez, Erika, Sandoval-Hernández, Monserrat, Lourival Possani, and Rosenstein, Yvonne

Abstract

Proteins differentially expressed when incubating the unstimulated cells with the Vm24 toxin. Proteins identified with the mass spectrometry-based quantitative proteomic analysis, with at least 1.5-fold change in either direction and that were significantly (p

Published
2018
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33. Proteomic Analysis of Heloderma horridum horridumVenom: Assessment to Its Transcriptome and Newfound Proteins

Author

Lino-López, Gisela J., Ruiz-May, Eliel, Elizalde-Contreras, José M., Jiménez-Vargas, Juana M., Rodríguez-Vázquez, Armando, González-Carrillo, Gabino, Bojórquez-Velázquez, Esaú, García-Villalvazo, Patricia E., Bermúdez-Guzmán, Manuel de J., Zatarain-Palacios, Rocio, Vázquez-Vuelvas, Oscar F., Valdez-Velázquez, Laura L., and Corzo, Gerardo

Abstract

Heloderma horridumhorridum, a venomous reptile native to America, has a venom with potential applications in treating type II diabetes. In this work, H. h. horridumvenom was extracted, lyophilized, and characterized using enzymatic assays for hyaluronidase, phospholipase, and protease. Proteomic analysis of the venom was conducted employing bottom-up/shotgun approaches, SDS-PAGE, high-pH reversed-phase chromatography, and fractionation of tryptic peptides using nano-LC-MS/MS. The proteins found in H. h. horridumvenom were reviewed according to the classification of the transcriptome previously reported. The proteomic approach identified 101 enzymes, 36 other proteins, 15 protein inhibitors, 11 host defense proteins, and 1 toxin, including novel venom components such as calcium-binding proteins, phospholipase A2 inhibitors, serpins, cathepsin, subtilases, carboxypeptidase-like, aminopeptidases, glycoside hydrolases, thioredoxin transferases, acid ceramidase-like, enolase, multicopper oxidases, phosphoglucose isomerase (PGI), fructose-1,6-bisphosphatase class 1, pentraxin-related, peptidylglycine α-hydroxylating monooxygenase/peptidyl-hydroxyglycine α-amidating lyase, carbonic anhydrase, acetylcholinesterase, dipeptidylpeptidase, and lysozymes. These findings contribute to understanding the venomous nature of H. h. horridumand highlight its potential as a source of bioactive compounds. Data are available via PRoteomeXchange with the identifier PXD052417.

Published
2024
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38. Applicability of biological fertility indicators for effective birth control after orthotopic liver transplantation.

Author

Huete, María Eugenia, Castillo, Antonio, Marcos, Helena, Vargas, Juana, Pérez de Lema, Guillermo, and Baños, Isolina

Subjects
BIOINDICATORS, BIRTH control, LIVER transplantation, HUMAN reproduction, HIGH-risk pregnancy
Abstract

In young women, a return to normal life after organ transplantation includes the possibility of fulfilling her possible motherhood wishes. Doctors should carefully balance which methods to propose, and decide on grounds of individual medical, safety and patient-derived conditions (Hilger et al. [6]). Statistical analysis of the main fertility associated indicators of the patient during the first 12 cycles after the end of amenorrhoea. From that time point onwards the patient was carefully monitored at her transplantation hospital by a multidisciplinary team composed of liver-transplant physicians and high-risk pregnancy unit obstetricians. [Extracted from the article]

Published
2020
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40. Toxinas de alacrán que afectan a canales de potasio del tipo herg1

Author

Jiménez Vargas, Juana María and Possani, Lourival Domingos

Subjects
Ciencias Biológicas, Químicas y de la Salud, Biología, Fisiología
Abstract

tesis que para obtener el grado de Doctorado en Ciencias Biomédicas, presenta Juana Maria Jimenez Vargas ; asesor Lourival Domingos Possani Postay94 páginas : ilustracionesDoctorado en Ciencias Biomédicas UNAM, Centro de Ciencias Genómicas, 2012

Published
2012

49. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins

Author

Wang, Xueli, Jimenez-Vargas, Juana Maria, Xu, Chenqi, Possani, Lourival D., and Zhu, Shunyi

Subjects
*GENETIC mutation, *TOXINS, *SCORPIONS, *SITE-specific mutagenesis, *BIOLOGICAL evolution, *GENETICS
Abstract

Abstract: Scorpion γ-KTx toxins are important molecular tools for studying physiological and pharmacological functions of human ether-á-go-go related gene (hERG) K+ channels. To pinpoint functional residues of this class of toxins involved in channel binding, we employed a combined approach that integrates evolutionary information and site-directed mutagenesis. Among three positively selected sites (PSSs) identified here, two (Gln18 and Met35) were found to be associated with the toxin’s function because their changes significantly decreased the potency of ErgTx1 (also called CnErg1) on hERG1 channel. On the contrary, no potency alteration was observed at the third PSS (Ala42) when the mutation was introduced, which could be due to its location far from the functional surface of the toxin. Our strategy will accelerate the research of structure–function relationship of scorpion K+ channel toxins. [Copyright &y& Elsevier]

Published
2012
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