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1. Efficiency of Text Message Contact on Medical Safety in Outpatient Surgery: Retrospective Study

Author

Peuchot, Jeremy, Allard, Etienne, Dureuil, Bertrand, Veber, Benoit, and Compère, Vincent

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundEstablishing pre- and postoperative contact with patients is part of successful medical management in outpatient surgery. In France, this is mostly done via telephone. Automated information with short message service (SMS) reminders might be an interesting alternative to increase the rate of compliance with preoperative instructions, but no study has shown the safety of this approach. ObjectiveThe objective of this study was to evaluate the impact of pre- and postoperative automated information with SMS reminders on medical safety in outpatient surgery. MethodsWe conducted a retrospective, single-center, nonrandomized, controlled study with a before-after design. All adult patients who had outpatient surgery between September 2016 and December 2017 in our university hospital center were included. Before April 2017, patients were contacted by telephone by an outpatient surgery nurse. After April 2017, patients were contacted by SMS reminder. All patients were contacted the day before and the day after surgery. Patients contacted by SMS reminder were also contacted on day 7 after surgery. The primary end point was the conversion rate to full-time hospitalization. Secondary end points were hospitalization causes (anesthetic, surgical, organizational) and hospitalization costs. ResultsA total of 4388 patients were included, 2160 before and 2228 after the introduction of SMS reminders. The conversion rate to full-time hospitalization was 34/4388 (0.77%) with a difference between SMS group (8/2228, 0.36%) and telephone group (26/2160, 1.20%). The cost of SMS reminders was estimated as half that of telephone calls. ConclusionsIn this work, we report a decrease in the rate of conversion to full-time hospitalization with the use of pre- and postoperative SMS reminders. This new approach could represent a safe and cost-effective method in an outpatient surgery setting.

Published
2020
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2. Use of the Smartphone App WhatsApp as an E-Learning Method for Medical Residents: Multicenter Controlled Randomized Trial

Author

Clavier, Thomas, Ramen, Julie, Dureuil, Bertrand, Veber, Benoit, Hanouz, Jean-Luc, Dupont, Hervé, Lebuffe, Gilles, Besnier, Emmanuel, and Compere, Vincent

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundThe WhatsApp smartphone app is the most widely used instant messaging app in the world. Recent studies reported the use of WhatsApp for educational purposes, but there is no prospective study comparing WhatsApp’s pedagogical effectiveness to that of any other teaching modality. ObjectiveThe main objective of this study was to measure the impact of a learning program via WhatsApp on clinical reasoning in medical residents. MethodsThis prospective, randomized, multicenter study was conducted among first- and second-year anesthesiology residents (offline recruitment) from four university hospitals in France. Residents were randomized in two groups of online teaching (WhatsApp and control). The WhatsApp group benefited from daily delivery of teaching documents on the WhatsApp app and a weekly clinical case supervised by a senior physician. In the control group, residents had access to the same documents via a traditional computer electronic learning (e-learning) platform. Medical reasoning was self-assessed online by a script concordance test (SCT; primary parameter), and medical knowledge was assessed using multiple-choice questions (MCQs). The residents also completed an online satisfaction questionnaire. ResultsIn this study, 62 residents were randomized (32 to the WhatsApp group and 30 to the control group) and 22 residents in each group answered the online final evaluation. We found a difference between the WhatsApp and control groups for SCTs (60% [SD 9%] vs 68% [SD 11%]; P=.006) but no difference for MCQs (18/30 [SD 4] vs 16/30 [SD 4]; P=.22). Concerning satisfaction, there was a better global satisfaction rate in the WhatsApp group than in the control group (8/10 [interquartile range 8-9] vs 8/10 [interquartile range 8-8]; P=.049). ConclusionsCompared to traditional e-learning, the use of WhatsApp for teaching residents was associated with worse clinical reasoning despite better global appreciation. The use of WhatsApp probably contributes to the dispersion of attention linked to the use of the smartphone. The impact of smartphones on clinical reasoning should be studied further.

Published
2019
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4. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial

Author

Bouglé, Adrien, Tuffet, Sophie, Federici, Laura, Leone, Marc, Monsel, Antoine, Dessalle, Thomas, Amour, Julien, Dahyot-Fizelier, Claire, Barbier, François, Luyt, Charles-Edouard, Langeron, Olivier, Cholley, Bernard, Pottecher, Julien, Hissem, Tarik, Lefrant, Jean-Yves, Veber, Benoit, Legrand, Matthieu, Demoule, Alexandre, Kalfon, Pierre, Constantin, Jean-Michel, Rousseau, Alexandra, Simon, Tabassome, and Foucrier, Arnaud

Published
2022
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6. Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study

Author

Bassetti, Matteo, Vena, Antonio, Giacobbe, Daniele R., Trucchi, Cecilia, Ansaldi, Filippo, Antonelli, Massimo, Adamkova, Vaclava, Alicino, Cristiano, Almyroudi, Maria-Panagiota, Atchade, Enora, Azzini, Anna M., Brugnaro, Pierluigi, Carannante, Novella, Peghin, Maddalena, Berruti, Marco, Carnelutti, Alessia, Castaldo, Nadia, Corcione, Silvia, Cortegiani, Andrea, Dimopoulos, George, Dubler, Simon, García-Garmendia, José L., Girardis, Massimo, Cornely, Oliver A., Ianniruberto, Stefano, Kullberg, Bart Jan, Lagrou, Katrien, Lebihan, Clement, Luzzati, Roberto, Malbrain, Manu, Merelli, Maria, Marques, Ana J., Martin-Loeches, Ignacio, Mesini, Alessio, Paiva, José-Artur, Raineri, Santi Maurizio, Rautemaa-Richardson, Riina, Schouten, Jeroen, Spapen, Herbert, Tasioudis, Polychronis, Timsit, Jean-François, Tisa, Valentino, Tumbarello, Mario, Van den Berg, Charlotte H. S. B., Veber, Benoit, Venditti, Mario, Voiriot, Guillaume, Wauters, Joost, Zappella, Nathalie, and Montravers, Philippe

Published
2022
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8. Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial

Author

Bouglé, Adrien, Tuffet, Sophie, Federici, Laura, Leone, Marc, Monsel, Antoine, Dessalle, Thomas, Amour, Julien, Dahyot-Fizelier, Claire, Barbier, François, Luyt, Charles-Edouard, Langeron, Olivier, Cholley, Bernard, Pottecher, Julien, Hissem, Tarik, Lefrant, Jean-Yves, Veber, Benoit, Legrand, Matthieu, Demoule, Alexandre, Kalfon, Pierre, Constantin, Jean-Michel, Rousseau, Alexandra, Simon, Tabassome, and Foucrier, Arnaud

Published
2022
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10. Conflit en situation de limitation ou d’arrêt de traitement en réanimation

Author

Brunel, Elodie, Gateau, Valérie, Guibet Lafaye, Caroline, Kandelman, Stanislas, Lallemant, Florence, Le Boudec, Anne, Ledorze, Matthieu, Muller, Laurent, Nouette-Gaulain, Karine, Perrigault, Pierre-François, Rutter, Nadège, Samain, Emmanuel, Visquesnel, Gérald, Zilberstein, Luca, Michel, Fabrice, Claudot, Frédérique, and Veber, Benoit

Published
2022
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14. Guidelines: Anaesthesia in the context of COVID-19 pandemic

Author

Velly, Lionel, Gayat, Etienne, Quintard, Hervé, Weiss, Emmanuel, De Jong, Audrey, Cuvillon, Philippe, Audibert, Gérard, Amour, Julien, Beaussier, Marc, Biais, Matthieu, Bloc, Sébastien, Bonnet, Marie Pierre, Bouzat, Pierre, Brezac, Gilles, Dahyot-Fizelier, Claire, Dahmani, Souhayl, de Queiroz, Mathilde, Di Maria, Sophie, Ecoffey, Claude, Futier, Emmanuel, Geeraerts, Thomas, Jaber, Haithem, Heyer, Laurent, Hoteit, Rim, Joannes-Boyau, Olivier, Kern, Delphine, Langeron, Olivier, Lasocki, Sigismond, Launey, Yoan, le Saché, Frederic, Lukaszewicz, Anne Claire, Maurice-Szamburski, Axel, Mayeur, Nicolas, Michel, Fabrice, Minville, Vincent, Mirek, Sébastien, Montravers, Philippe, Morau, Estelle, Muller, Laurent, Muret, Jane, Nouette-Gaulain, Karine, Orban, Jean Christophe, Orliaguet, Gilles, Perrigault, Pierre François, Plantet, Florence, Pottecher, Julien, Quesnel, Christophe, Reubrecht, Vanessa, Rozec, Bertrand, Tavernier, Benoit, Veber, Benoit, Veyckmans, Francis, Charbonneau, Hélène, Constant, Isabelle, Frasca, Denis, Fischer, Marc-Olivier, Huraux, Catherine, Blet, Alice, and Garnier, Marc

Published
2020
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17. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Author

Sophie, Cayot, Thomas, Godet, Renaud, Guerin, Camille, Verlac, Russel, Chabanne, Bernard, Cosserant, Raiko, Blondonnet, Alexandre, Lautrette, Nathanael, Eisenmann, Laurent, Muller, Pablo, Massanet, Caroline, Boutin, Saber, Barbar, Claire, Roger, Fouad, Belafia, Moussa, Cisse, Marion, Monnin, Matthieu, Conseil, Julie, Carr, Audrey, De Jong, Auguste, Dargent, Pascal, Andreu, Thomas, Lebouvrier, Yoann, Launey, Antoine, Roquilly, Raphael, Cinotti, Anne-Charlotte, Tellier, Mathilde, Barbaz, Benjamin, Cohen, Edouard, Lemarche, Pierre-Marie, Bertrand, Charlotte, Arberlot, Laurent, Zieleskiewicz, Emmanuelle, Hammad, Garry, Duclos, Calypso, Mathie, Herve, Dupont, Benoit, Veber, Jean-Christophe, Orban, Hervé, Quintard, Thomas, Rimmele, Julien, Crozon-Clauzel, Marinne, Le Core, Fabien, Grelon, Mona, Assefi, Frank, Petitas, Jerome, Morel, Serge, Molliex, Nanadougmar, Hadanou, Constantin, Jean-Michel, Jabaudon, Matthieu, Lefrant, Jean-Yves, Jaber, Samir, Quenot, Jean-Pierre, Langeron, Olivier, Ferrandière, Martine, Grelon, Fabien, Seguin, Philippe, Ichai, Carole, Veber, Benoit, Souweine, Bertrand, Uberti, Thomas, Lasocki, Sigismond, Legay, François, Leone, Marc, Eisenmann, Nathanael, Dahyot-Fizelier, Claire, Dupont, Hervé, Asehnoune, Karim, Sossou, Achille, Chanques, Gérald, Muller, Laurent, Bazin, Jean-Etienne, Monsel, Antoine, Borao, Lucile, Garcier, Jean-Marc, Rouby, Jean-Jacques, Pereira, Bruno, and Futier, Emmanuel

Published
2019
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22. Reducing diarrhoea in an adult surgical intensive care unit: A quality improvement study.

Author

Occhiali, Emilie, Rodrigues, Bastien, Prieur, Wendy, Tiarci, Safia, Carmon, Nicolas, Veber, Benoit, and Achamrah, Najate

Subjects
DIARRHEA prevention, INTENSIVE care units, LENGTH of stay in hospitals, STATISTICAL significance, DIARRHEA, CAREGIVERS, NURSING, CRITICALLY ill, PATIENTS, HEALTH outcome assessment, FISHER exact test, MANN Whitney U Test, PRE-tests & post-tests, SURVEYS, CRITICAL care nurses, MEDICAL protocols, QUALITY assurance, CRITICAL care medicine, DESCRIPTIVE statistics, DATA analysis software, DISEASE management
Abstract

Background: Although diarrhoea is a real source of morbidity for critically ill patients, this issue has been little studied, making it difficult to understand its mechanisms and management. Aims: We conducted a quality improvement study in an adult surgical intensive care unit before/after the implementation of a specific protocol to firstly improve diarrhoea management for patient benefit and secondly to understand the impact on caregivers. Study design: The first part of this before/after study consisted in assessing the proportion of patients receiving an anti‐diarrheal treatment before (phase I)/after (phase II) the implementation of the protocol. The second part of the study was to survey the caregivers on this topic. Results: Sixty four adults were included (33 in phase I; 31 in phase II) with 280 diarrheal episodes (129 in phase I; 151 in phase II). The proportion of patients who received at least one anti‐diarrheal treatment was similar between the two phases (79% (26/33) vs. 68% (21/31), p =.40). Diarrhoea incidence was also similar (9% (33 patients/368 admissions) vs. 11% (31 patients/275 admissions), p =.35). The delay to initiate at least one treatment was significantly shorter in phase II (2 days [1–7] vs. 0 day [0–2]; p <.001). The patients' rehabilitation was no longer impacted by the occurrence of a diarrheal episode in phase II (39% (13/33) vs. 0% (0/31), p <.001). Eighty team members completed the surveys in phase I and 70 in phase II. Caregivers perceived diarrhoea like a burden and its economic impact remained high. Conclusions: The implementation of a protocol for the management of ICU diarrhoea did not increase the proportion of patients treated, but it did significantly improve the delay to initiate a treatment. The patients' rehabilitation was no longer affected by diarrhoea. Relevance to clinical practice: The use of specific anti‐diarrhoea guidelines may help to reduce the burden of diarrhoea in an ICU. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Use of brain diffusion tensor imaging for the prediction of long-term neurological outcomes in patients after cardiac arrest: a multicentre, international, prospective, observational, cohort study

Author

Constantin, Jean-Michel, Chastre, Jean, Amour, Julien, Vezinet, Corine, Rouby, Jean-Jacques, Raux, Mathieu, Langeron, Olivier, Degos, Vincent, Bolgert, Francis, Weiss, Nicolas, Similowski, Thomas, Demoule, Alexandre, Duguet, Alexandre, Tollard, Eleonore, Veber, Benoit, Lotterie, Jean-Albert, SANCHEZ-PENA, Paola, Génestal, Michèle, Patassini, Mirko, Velly, Lionel, Perlbarg, Vincent, Boulier, Thomas, Adam, Nicolas, Delphine, Sebastien, Luyt, Charles-Edouard, Battisti, Valentine, Torkomian, Gregory, Arbelot, Charlotte, Chabanne, Russell, Jean, Betty, Di Perri, Carol, Laureys, Steven, Citerio, Giuseppe, Vargiolu, Alessia, Rohaut, Benjamin, Bruder, Nicolas, Girard, Nadine, Silva, Stein, Cottenceau, Vincent, Tourdias, Thomas, Coulon, Olivier, Riou, Bruno, Naccache, Lionel, Gupta, Rajiv, Benali, Habib, Galanaud, Damien, and Puybasset, Louis

Published
2018
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28. Gender-based violence among healthcare students: Prevalence, description and associated factors.

Author

Tavolacci, Marie-Pierre, Karmaly, Alice, El Gharbi-Hamza, Najla, Veber, Benoit, and Ladner, Joel

Subjects
VIOLENCE against women, GENDER-based violence, STUDENT volunteers, SEXISM in language, MEDICAL personnel, NURSING schools
Abstract

Objectives: The aims of the current study were 1) to provide the prevalence of five types of gender-based violence (GBV) among male and female healthcare students; 2) to describe perpetrators' status, where the GBV occurred, and psychological and behavioural impacts of the GBV; and 3) to identify factors associated with GBV. Design: A cross-sectional study was conducted among voluntary healthcare students in France. Setting: Health Campus at Rouen and nursing schools in Normandy, France. Participants: Volunteer healthcare students of 18 years and over. Data collected: Five types of GBV were recorded: GBV1: damage to a person's image due to a sexual connotation on social networks, GBV2: sexist remarks and behaviour, GBV3: comments with sexual connotations, GBV4: sexual assaults and GBV5: rape or attempted rape. Perpetrators' status, where the GBV occurred, psychological and behavioural impacts of GBV were also recorded. Results: One thousand one hundred and fifty-two students were included. The mean age was 20.8 years (SD = 2.26), 82.6% of students were women (0.4% non-binary). Since the beginning of their healthcare study, 41.2% of students CI 95% [39.7–42.6] were victim of at least one type of GBV: 15.8% among men CI 95% [13.2–18.4] and 46.0% CI 95% [44.4–47.6] among women (p < 0.001). The perpetrators were student peers, regardless of the type of GBV, healthcare workers for the GB2 and GBV3, and patients except for GBV5. The main consequences of GBV on health was psychological and eating related. After multivariate analysis, being a woman, LGBTQ+ (Lesbian, Gay, Bi, Trans, Queer and other), a nurse, a physiotherapist student, having a job, living with roommates and year of study were risk factors for GBV. Conclusion: GBV is so common at healthcare universities and could have such severe consequences for students that more work is needed to generate a culture change and ensure safe learning environments. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial

Author

Montravers, Philippe, Tubach, Florence, Lescot, Thomas, Veber, Benoit, Esposito-Farèse, Marina, Seguin, Philippe, and Paugam, Catherine

Subjects
Bacteria -- Health aspects -- Comparative analysis, Abdomen -- Abscess, Drug resistance in microorganisms -- Drug therapy, Infection -- Drug therapy, Clinical trials -- Health aspects -- Comparative analysis, Antibiotics -- Rankings, Hospital patients -- Drug therapy, Health care industry
Abstract

Purpose Shortening the duration of antibiotic therapy (ABT) is a key measure in antimicrobial stewardship. The optimal duration of ABT for treatment of postoperative intra-abdominal infections (PIAI) in critically ill patients is unknown. Methods A multicentre prospective randomised trial conducted in 21 French intensive care units (ICU) between May 2011 and February 2015 compared the efficacy and safety of 8-day versus 15-day antibiotic therapy in critically ill patients with PIAI. Among 410 eligible patients (adequate source control and ABT on day 0), 249 patients were randomly assigned on day 8 to either stop ABT immediately (n = 126) or to continue ABT until day 15 (n = 123). The primary endpoint was the number of antibiotic-free days between randomisation (day 8) and day 28. Secondary outcomes were death, ICU and hospital length of stay, emergence of multidrug-resistant (MDR) bacteria and reoperation rate, with 45-day follow-up. Results Patients treated for 8 days had a higher median number of antibiotic-free days than those treated for 15 days (15 [6-20] vs 12 [6-13] days, respectively; P < 0.0001) (Wilcoxon rank difference 4.99 days [95% CI 2.99-6.00; P < 0.0001). Equivalence was established in terms of 45-day mortality (rate difference 0.038, 95% CI - 0.013 to 0.061). Treatments did not differ in terms of ICU and hospital length of stay, emergence of MDR bacteria or reoperation rate, while subsequent drainages between day 8 and day 45 were observed following short-course ABT (P = 0.041). Conclusion Short-course antibiotic therapy in critically ill ICU patients with PIAI reduces antibiotic exposure. Continuation of treatment until day 15 is not associated with any clinical benefit. Clinicaltrials.gov identifier NCT01311765., Author(s): Philippe Montravers [sup.1] [sup.18], Florence Tubach [sup.2], Thomas Lescot [sup.3], Benoit Veber [sup.4], Marina Esposito-Farèse [sup.5], Philippe Seguin [sup.6], Catherine Paugam [sup.7], Alain Lepape [sup.8], Claude Meistelman [sup.9], Joel [...]

Published
2018
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31. Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Author

Bassetti, Matteo, Giacobbe, Daniele R., Vena, Antonio, Trucchi, Cecilia, Ansaldi, Filippo, Antonelli, Massimo, Adamkova, Vaclava, Alicino, Cristiano, Almyroudi, Maria-Panagiota, Atchade, Enora, Azzini, Anna M., Carannante, Novella, Carnelutti, Alessia, Corcione, Silvia, Cortegiani, Andrea, Dimopoulos, George, Dubler, Simon, García-Garmendia, José L., Girardis, Massimo, Cornely, Oliver A., Ianniruberto, Stefano, Kullberg, Bart Jan, Lagrou, Katrien, Le Bihan, Clement, Luzzati, Roberto, Malbrain, Manu L. N. G., Merelli, Maria, Marques, Ana J., Martin-Loeches, Ignacio, Mesini, Alessio, Paiva, José-Artur, Peghin, Maddalena, Raineri, Santi Maurizio, Rautemaa-Richardson, Riina, Schouten, Jeroen, Brugnaro, Pierluigi, Spapen, Herbert, Tasioudis, Polychronis, Timsit, Jean-François, Tisa, Valentino, Tumbarello, Mario, van den Berg, Charlotte H. S. B., Veber, Benoit, Venditti, Mario, Voiriot, Guillaume, Wauters, Joost, and Montravers, Philippe

Published
2019
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33. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Author

Kamilia, Chtara, Regaieg, Kais, Baccouch, Najeh, Chelly, Hedi, Bahloul, Mabrouk, Bouaziz, Mounir, Jendoubi, Ali, Abbes, Ahmed, Belhaouane, Houda, Nasri, Oussama, Jenzri, Layla, Ghedira, Salma, Houissa, Mohamed, Belkadi, Kamal, Harti, Youness, Nsiri, Afak, Khaleq, Khalid, Hamoudi, Driss, Harrar, Rachid, Thieffry, Camille, Wallet, Frédéric, Parmentier-Decrucq, Erika, Favory, Raphaël, Mathieu, Daniel, Poissy, Julien, Lafon, Thomas, Vignon, Philippe, Begot, Emmanuelle, Appert, Alexandra, Hadj, Mathilde, Claverie, Paul, Matt, Morgan, Barraud, Olivier, François, Bruno, Jamoussi, Amira, Jazia, Amira Ben, Marhbène, Takoua, Lakhdhar, Dhouha, Khelil, Jalila Ben, Besbes, Mohamed, Goutay, Julien, Blazejewski, Caroline, Joly-Durand, Isabelle, Pirlet, Isabelle, Weillaert, Marie Pierre, Beague, Sebastien, Aziz, Soufi, Hafiane, Reda, Hattabi, Khalid, Bouhouri, Mohamed Aziz, Hammoudi, Driss, Fadil, Abdelaziz, Harrar, Rachid Al, Zerouali, Khalid, Medhioub, Fatma Kaaniche, Allela, Rania, Algia, Najla Ben, Cherif, Samar, Slaoui, Mohamed Taoufik, Boubia, Souhail, Hafiani, Y., Khaoudi, A., Cherkab, R., Elallam, W., Elkettani, C., Barrou, L., Ridaii, M., Mehdi, Rihi El, Schimpf, Caroline, Mizrahi, Assaf, Pilmis, Benoît, Le Monnier, Alban, Tiercelet, Kelly, Cherin, Mélanie, Bruel, Cédric, Philippart, Francois, Bailly, Sébastien, Lucet, Jc, Lepape, Alain, L’hériteau, François, Aupée, Martine, Bervas, Caroline, Boussat, Sandrine, Berger-Carbonne, Anne, Machut, Anaïs, Savey, Anne, Timsit, Jean-François, Razazi, Keyvan, Rosman, Jérémy, de Prost, Nicolas, Carteaux, Guillaume, Jansen, Chloe, Decousser, Jean Winoc, Brun-Buisson, Christian, Dessap, Armand Mekontso, M’rad, Aymen, Ouali, Zouhour, Barghouth, Manel, Kouatchet, Achille, Mahieu, Rafael, Weiss, Emmanuel, Schnell, David, Zahar, Jean-Ralph, Artiguenave, Margaux, Sophie, Paktoris-Papine, Espinasse, Florence, Sayed, Faten El, Dinh, Aurélien, Charron, Cyril, Geri, Guillaume, Vieillard-Baron, Antoine, Repessé, Xavier, Kallel, Hatem, Mayence, Claire, Houcke, Stéphanie, Guegueniat, Pascal, Hommel, Didier, Dhifaoui, Kaouther, Hajjej, Zied, Fatnassi, Amira, Sellami, Walid, Labbene, Iheb, Ferjani, Mustapha, Dachraoui, Fahmi, Nakkaa, Sabrine, M’ghirbi, Abdelwaheb, Adhieb, Ali, Braiek, Dhouha Ben, Hraiech, Kmar, Ousji, Ali, Ouanes, Islem, Zaineb, Hammouda, Abdallah, Saousen Ben, Ouanes-Besbes, Lamia, Abroug, Fekri, Klein, Simon, Miquet, Mattéo, Thouret, Jean-Marc, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Merhbene, Takoua, Derreumaux, Celine, Seguin, Thierry, Conil, Jean-Marie, Kelway, Charlotte, Blasco, Valery, Nafati, Cyril, Harti, Karim, Reydellet, Laurent, Albanese, Jacques, Aicha, Narjess Ben, Meddeb, Khaoula, Khedher, Ahmed, Ayachi, Jihene, Fraj, Nesrine, Sma, Nesrine, Chouchene, Imed, Boussarsar, Mohamed, Yedder, Soumaya Ben, Samoud, Walid, Radhouene, Bousselmi, Mariem, Bousselmi, Ammar, Asma, Cheikh, Asma Ben, Lakhal, Hend Ben, Khelfa, Messaouda, Hamdaoui, Yamina, Bouafia, Nabiha, Trampont, Timothée, Daix, Thomas, Legarçon, Vincent, Karam, Henri Hani, Pichon, Nicolas, Essafi, Fatma, Foudhaili, Nasreddine, Thabet, Hafedh, Blel, Youssef, Brahmi, Nozha, Ezzouine, Hanane, Kerrous, Mahmoud, Haoui, Saad El, Ahdil, Soufiane, Benslama, Abdellatif, Abidi, Khalid, Dendane, Tarek, Oussama, Ssouni, Belayachi, Jihane, Madani, Naoufal, Abouqal, Redouane, Zeggwagh, Amine Ali, Ghadhoune, Hatem, Chaari, Anis, Jihene, Guissouma, Allouche, Hend, Trabelsi, Insaf, Brahmi, Habib, Samet, Mohamed, Ghord, Hatem El, Habiba, Ben Sik Ali, Hajer, Nouira, Tilouch, Najla, Yaakoubi, Sondes, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Arcizet, Julien, Leroy, Bertrand, Abdulmalack, Caroline, Renzullo, Catherine, Hamet, Maël, Doise, Jean-Marc, Coutet, Jérôme, Cheikh, Chaigar Mohammed, Quechar, Zakaria, Joris, Magalie, Beauport, Dimitri Titeca, Kontar, Loay, Lebon, Delphine, Gruson, Bérengère, Slama, Michel, Marolleau, Jean-Pierre, Maizel, Julien, Gorham, Julie, Ameye, Lieveke, Berghmans, Thierry, Paesmans, Marianne, Sculier, Jean-Paul, Meert, Anne-Pascale, Guillot, Max, Ledoux, Marie-Pierre, Braun, Thierry, Maestraggi, Quentin, Michard, Baptiste, Castelain, Vincent, Herbrecht, Raoul, Schneider, Francis, Couffin, Severine, Lobo, David, Mongardon, Nicolas, Dhonneur, Gilles, Mounier, Roman, Le Borgne, Pierrick, Couraud, Sophie, Herbrecht, Jean-Etienne, Boivin, Alexandra, Lefebvre, François, Bilbault, Pascal, Zelmat, Setti-Aouicha, Batouche, Djamila-Djahida, Mazour, Fatima, Chaffi, Belkacem, Benatta, Nadia, Sik, Ali Habiba, Talik, I., Perrier, Maxime, Gouteix, Eliane, Koubi, Claude, Escavy, Annabelle, Guilbaut, Victoria, Fosse, Jean-Philippe, Jazia, Rahma Ben, Abdelghani, Ahmed, Cungi, Pierre-Julien, Bordes, Julien, Nguyen, Cédric, Pierrou, Candice, Cruc, Maximilien, Benois, Alain, Duprez, Frédéric, Bonus, Thierry, Cuvelier, Grégory, Ollieuz, Sandra, Machayekhi, Sharam, Paciorkowski, Frédéric, Reychler, Gregory, Coudroy, Remi, Thille, Arnaud W., Drouot, 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M., Olandzobo, A. G., Herbland, Alexandre, Richard, Marie, Girard, Nicolas, Lambron, Lucile, Lesieur, Olivier, Wainschtein, Sarah, Hubert, Sidonie, Hugues, Albane, Tran, Marc, Bouillard, Philippe, Loteanu, Vlad, Leloup, Maxime, Laurent, Alexandra, Lheureux, Florent, Prestifilippo, Alessia, Cruz, Martin Delgado Maria, Romain, Rigal, Antonelli, Massimo, Blanch, Torra Lluis, Bonnetain, Franck, Grazzia-Bocci, Maria, Mancebo, Jordi, Samain, Emmanuel, Paul, Hebert, Capellier, Gilles, Zavgorodniaia, Taissa, Soichot, Marion, Malissin, Isabelle, Voicu, Sebastian, Garçon, Pierre, Goury, Antoine, Kerdjana, Lamia, Deye, Nicolas, Bourgogne, Emmanuel, Megarbane, Bruno, Mejri, Olfa, Hmida, Marwa Ben, Tannous, Salma, Chevillard, Lucie, Labat, Laurence, Risede, Patricia, Fredj, Hana, Léger, Maxime, Brunet, Marion, Le Roux, Gaël, Boels, David, Lerolle, Nicolas, Farah, Souaad, Amiel-Niemann, Hélène, Kubis, Nathalie, Declèves, Xavier, Peyraux, Nicoals, Baud, Frederic, Serafini, Micaela, Alvarez, Jean-Claude, Heinzelman, 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Marjanovic, Nicolas, Palamin, Nicola, L’Her, Erwan, Bailly, Arthur, Boisramé-Helms, Julie, Champigneulle, Benoit, Kamel, Toufik, Mercier, Emmanuelle, Le Thuaut, Aurélie, Lascarrou, Jean-Baptiste, Rolle, Amélie, De Jong, Audrey, Chanques, Gérald, Jaber, Samir, Hariri, Geoffroy, Baudel, Jean-Luc, Dubée, Vincent, Preda, Gabriel, Bourcier, Simon, Joffre, Jeremie, Bigé, Naïke, Ait-Oufella, Hafid, Maury, Eric, Mater, Houda, Merdji, Hamid, Grimaldi, David, Rousseau, Christophe, Mira, Jean-Paul, Chiche, Jean-Daniel, Sedghiani, Ines, Benabderrahim, A., Hamdi, Dhekra, Jendoubi, Asma, Cherif, Mohamed Ali, Hechmi, Youssef Zied El, Zouheir, Jerbi, Bagate, François, Bousselmi, Radhwen, Schortgen, Frédérique, Asfar, Pierre, Guérot, Emmanuel, Fabien, Grelon, Anguel, Nadia, Sigismond, Lasocki, Matthieu, Henry-Lagarrigue, Gonzalez, Frédéric, François, Legay, Guitton, Christophe, Schenck, Maleka, Jean-Marc, Doise, Dreyfuss, Didier, Radermacher, Peter, Frère, Antoine, Martin-Lefèvre, Laurent, Colin, Gwenhaël, Fiancette, Maud, Henry-Laguarrigue, Matthieu, Lacherade, Jean-Claude, Lebert, Christine, Vinatier, Isabelle, Yehia, Aihem, Joret, Aurélie, Menunier-Beillard, Nicolas, Benzekri-Lefevre, Dalila, Desachy, Arnaud, Bellec, Fréderic, Plantefève, Gaëtan, Quenot, Jean-Pierre, Meziani, Ferhat, Tavernier, Elsa, Ehrmann, Stephan, Chudeau, Nicolas, Raveau, Tommy, Moal, Valérie, Houillier, Pascal, Rouve, Emmanuelle, Lakhal, Karim, Gandonnière, Charlotte Salmon, Jouan, Youenn, Bodet-Contentin, Laetitia, Balmier, Adrien, Messika, Jonathan, De Montmollin, Etienne, Pouyet, Victorine, Sztrymf, Benjamin, Thiagarajah, Abirami, Roux, Damien, De Chambrun, Marc Pineton, Luyt, Charles-Edouard, Beloncle, François, Zapella, Nathalie, Ledochowsky, Stanislas, Terzi, Nicolas, Mazou, Jean-Marc, Sonneville, Romain, Paulus, Sylvie, Fedun, Yannick, Landais, Mickael, Raphalen, Jean-Herlé, Combes, Alain, Amoura, Zahir, Jacquemin, Aemilia, Guerrero, Felipe, Marcheix, Bertrand, Hernandez, Nicolas, Fourcade, Olivier, Georges, Bernard, Delmas, Clément, Makoudi, Sarah, Genton, Audrey, Bernard, Rémy, Lebreton, Guillaume, Amour, Julien, Mazet, Charlotte, Bounes, Fanny, Murat, Gurbuz, Cronier, Laure, Robin, Guillaume, Biendel, Caroline, Silva, Stein, Boubeche, Samia, Abriou, Caroline, Wurtz, Véronique, Scherrer, Vincent, Rey, Nathalie, Gastaldi, Gioia, Veber, Benoit, Doguet, Fabien, Gay, Arnaud, Dureuil, Bertrand, Besnier, Emmanuel, Rouget, Antoine, Gantois, Guillaume, Magalhaes, Eric, Wanono, Ruben, Smonig, Roland, Lermuzeaux, Mathilde, Lebut, Jordane, Olivier, Andremont, Dupuis, Claire, Radjou, Aguila, Mourvillier, Bruno, Neuville, Mathilde, D’ortho, Marie Pia, Bouadma, Lila, Rouvel-Tallec, Anny, Rudler, Marika, Weiss, Nicolas, Perlbarg, Vincent, Galanaud, Damien, Thabut, Dominique, Rachdi, Emna, Mhamdi, Ghada, Trifi, Ahlem, Abdelmalek, Rim, Abdellatif, Sami, Daly, Foued, Nasri, Rochdi, Tiouiri, Hanene, Lakhal, Salah Ben, Rousseau, Geoffroy, Asmolov, Romain, Grammatico-Guillon, Leslie, Auvet, Adrien, Laribi, Said, Garot, Denis, Dequin, Pierre François, Guillon, Antoine, Fergé, Jean-Louis, Abgrall, Gwénolé, Hinault, Ronan, Vally, Shazima, Roze, Benoit, Chaplain, Agathe, Chabartier, Cyrille, Savidan, Anne-Charlotte, Marie, Sabia, Cabie, Andre, Resiere, Dabor, Valentino, Ruddy, Mehdaoui, Hossein, Benarous, Lucas, Soda-Diop, Marième, Bouzana, Fouad, Perrin, Gilles, Bourenne, Jeremy, Eon, Béatrice, Lambert, Dominique, Trebuchon, Agnes, Poncelet, Géraldine, Le Bourgeois, Fleur, Michael, Levy, Camille, Guillot, Naudin, Jérôme, Deho, Anna, Dauger, Stéphane, Sauthier, Michaël, Bergeron-Gallant, Krystale, Emeriaud, Guillaume, Jouvet, Philippe, Tiebergien, Nicolas, Jacquet-Lagrèze, Matthias, Fellahi, Jean-Luc, Baudin, Florent, Essouri, Sandrine, Javouhey, Etienne, Guérin, Claude, Lampin, Marie, Mamouri, Ouardia, Devos, Patrick, Karaca-Altintas, Yasemin, Vinchon, Matthieu, Brossier, David, Eltaani, Redha, Teyssedre, Sonia, Sabine, Meyet, Bouchut, Jean-Christophe, Peguet, Olivier, Petitdemange, Lucie, Guilbert, Anne Sophie, Aoul, Nabil Tabet, Addou, Zakaria, Aouffen, Nabil, Anas, Benqqa, Kalouch, Samira, Yaqini, Khalid, Chlilek, Aziz, Abdou, Rchi, Gravellier, Perrine, Chantreuil, Julie, Travers, Nadine, Listrat, Antoine, Le Reun, Claire, Favrais, Geraldine, Coppere, Zoe, Blanot, Stéphane, Montmayeur, Juliette, Bronchard, Régis, Rolando, Stephane, Orliaguet, Gilles, Leger, Pierre-Louis, Rambaud, Jérôme, Thueux, Emilie, De Larrard, Alexandra, Berthelot, Véronique, Denot, Julien, Reymond, Marie, Amblard, Alain, Morin-Zorman, Sarah, Lengliné, Etienne, Pichereau, Claire, Mariotte, Eric, Emmanuel, Canet, Poujade, Julien, Trumpff, Guillaume, Janssen-Langenstein, Ralf, Harlay, Marie-Line, Zaid, Noorah, Ait-Ammar, Nawel, Bonnal, Christine, Merle, Jean-Claude, Botterel, Francoise, Levesque, Eric, Riad, Zakaria, Mezidi, Mehdi, Yonis, Hodane, Aublanc, Mylène, Perinel-Ragey, Sophie, Lissonde, Floriane, Louf-Durier, Aurore, Tapponnier, Romain, Louis, Bruno, Forel, Jean-Marie, Bisbal, Magali, Lehingue, Samuel, Rambaud, Romain, Adda, Mélanie, Hraiech, Sami, Marchi, Elisa, Roch, Antoine, Guerin, Vincent, Rozencwajg, Sacha, Schmidt, Matthieu, Hekimian, Guillaume, Bréchot, Nicolas, Trouillet, Jean Louis, Besset, Sébastien, Franchineau, Guillaume, Nieszkowska, Ania, Pascal, Leprince, Loiselle, Maud, Sarah, Chemam, Laurence, Dangers, Guillemette, Thomas, Jacquens, Alice, Kerever, Sebastien, Guidet, Bertrand, Aegerter, Philippe, Das, Vincent, Fartoukh, Muriel, Hayon, Jan, Desmard, Mathieu, Fulgencio, Jean-Pierre, Zuber, Benjamin, Soufi, A., Khaleq, K., Hamoudi, D., Garret, Charlotte, Peron, Matthieu, Coron, Emmanuel, Bretonnière, Cédric, Audureau, Etienne, Audrey, Winters, Christophe, Duvoux, Christian, Jacquelinet, Daniel, Azoulay, Cyrille, Feray, Aissaoui, Wissal, Rghioui, Kawtar, Haddad, Wafae, Barrou, Houcine, Carteaux-Taeib, Anna, Lupinacci, Renato, Manceau, Gilles, Jeune, Florence, Tresallet, Christophe, Habacha, Sahar, Fathallah, Ines, Zoubli, Aymen, Aloui, Rafaa, Kouraichi, Nadia, Jouet, Emilie, Badin, Julie, Fermier, Brice, Feller, Marc, Serie, Mathieu, Pillot, Jérôme, Marie, William, Gisbert-Mora, Chloé, Vinclair, Camille, Lesbordes, Pierre, Mathieu, Pascal, De Brabant, Fabienne, Muller, Emmanuel, Robaux, Marie-Aline, Giabicani, Mikhael, Marchalot, Antoine, Gelinotte, Stéphanie, Declercq, Pierre Louis, Eraldi, Jean-Pierre, Bougerol, François, Meunier-Beillard, Nicolas, Devilliers, Hervé, Rigaud, Jean-Philippe, Verrière, Camille, Ardisson, Fanny, Kentish-Barnes, Nancy, Jacq, Gwenaëlle, Chermak, Akli, Lautrette, Alexandre, Legrand, Matthieu, Soummer, Alexis, Thiery, Guillaume, Cottereau, Alice, Canet, Emmanuel, Caujolle, Marie, Allyn, Jérôme, Valance, Dorothée, Brulliard, Caroline, Martinet, Olivier, Jabot, Julien, Gallas, Thomas, Vandroux, David, Allou, Nicolas, Durand, Arthur, Nevière, Rémi, Delguste, Florian, Boulanger, Eric, Preau, Sebastien, Martin, Ruste, Cochet, Hélène, Ponthus, Jean Pierre, Amilien, Virginie, Tchir, Martial, Barsam, Elise, Ayoub, Mohsen, Georger, Jean Francois, Guillame, Izaute, Assaraf, Julie, Tripon, Simona, Mallet, Maxime, Barbara, Guilaume, Louis, Guillaume, Gaudry, Stéphane, Barbarot, Nicolas, Jamet, Angéline, Outin, Hervé, Gibot, Sébastien, Bollaert, Pierre-Edouard, Holleville, Mathilde, Legriel, Stéphane, Chateauneuf, Anne Laure, Cavelot, Sébastien, Moyer, Jean-Denis, Bedos, Jean Pierre, Merle, Philippe, Laine, Aurelie, Natalie, De Sa, Cornuault, Mathieu, Libot, Jérome, Asehnoune, Karim, Rozec, Bertrand, Dantal, Jacques, Videcoq, Michel, Degroote, Thècle, Jaillette, Emmanuelle, Zerimech, Farid, Malika, Balduyck, Llitjos, Jean-François, Amara, Marlène, Lacave, Guillaume, Pangon, Béatrice, Mavinga, José, Makunza, Joseph Nsiala, Mafuta, M. E., Yanga, Yves, Eric, Amisi, Ilunga, Jp, Kilembe, Ma, Alby-Laurent, Fanny, Toubiana, Julie, Mokline, Amel, Laajili, Achraf, Amri, Helmi, Rahmani, Imene, Mensi, Nidhal, Gharsallah, Lazheri, Tlaili, Sofiene, Gasri, Bahija, Hammouda, Rym, Messadi, Amen Allah, Allain, Pierre-Antoine, Gault, Nathallie, Paugam-Burtz, Catherine, Foucrier, Arnaud, Chatbri, Bassem, Bourbiaa, Yousra, Thabet, Lamia, Neuschwander, Arthur, Vincent, Looten, Beck, Jennifer, Vibol, Chhor, Amelie, Yavchitz, Resche-Rigon, Matthieu, Pirracchio, Jean MantzRomain, Bureau, Côme, Decavèle, Maxens, Campion, Sébastien, Ainsouya, Roukia, Niérat, Marie-Cécile, Prodanovic, Hélène, Raux, Mathieu, Similowski, Thomas, Dubé, Bruno-Pierre, Demiri, Suela, Dres, Martin, May, Faten, Quintard, Hervé, Kounis, Ilias, Saliba, Faouzi, André, Stephane, Boudon, Marc, Ichai, Philippe, Younes, Aline, Nakad, Lionel, Coilly, Audrey, Antonini, Teresa, Sobesky, Rodolphe, De Martin, Eleonora, Samuel, Didier, Hubert, Noemie, Nay, Mai-Anh, Auchabie, Johann, Giraudeau, Bruno, Jean, Reignier, Darmon, Michaël, Ruckly, Stephane, Garrouste-Orgeas, Maïté, Gratia, Elisabeth, Goldgran-Toledano, Dany, Jamali, Samir, Dumenil, Anne Sylvie, Schwebel, Carole, Brisard, Laurent, Bizouarn, Philippe, Lepoivre, Thierry, Nicolet, Johanna, Rigal, Jean Christophe, Roussel, Jean Christian, Cheurfa, Cherifa, Abily, Julien, Lescot, Thomas, Page, Isaline, Warnier, Stéphanie, Nys, Monique, Rousseau, Anne-Françoise, Damas, Pierre, Uhel, Fabrice, Lesouhaitier, Mathieu, Grégoire, Murielle, Gaudriot, Baptiste, Gacouin, Arnaud, Le Tulzo, Yves, Flecher, Erwan, Tarte, Karin, Tadié, Jean-Marc, Georges, Quentin, Soares, M., Jeon, Kyeongman, Oeyen, Sandra, Rhee, Chin Kook, Gruber, Pascale, Ostermann, Marlies, Hill, Quentin, Depuydt, Peter, Ferra, Christelle, Muller, Alice, Aurelie, Bourmaud, Niles, Christopher, Herbert, Fabien, Pied, Sylviane, Loridant, Séverine, François, Nadine, Bignon, Anne, Sendid, Boualem, Lemaitre, Caroline, Dupre, Celine, Zayene, Aymen, Portier, Lucie, De Freitas Caires, Nathalie, Lassalle, Philippe, Le Neindre, Aymeric, Selot, Pascal, Ferreiro, Daniel, Bonarek, Maria, Henriot, Stépahen, Rodriguez, Julie, Taddei, Mara, Di Bari, Mauro, Hickmann, Cheryl, Castanares-Zapatero, Diego, Deldicque, Louise, Van Den Bergh, Peter, Caty, Gilles, Roeseler, Jean, Francaux, Marc, Laterre, Pierre-François, Dupuis, Bastien, Machayeckhi, Sharam, Sarfati, Celine, Moore, Alex, Mendialdua, Paula, Rodet, Emilie, Pilorge, Catherine, Stephan, Francois, Rezaiguia-Delclaux, Saida, Dugernier, Jonathan, Hesse, Michel, Jumetz, Thibaud, Bialais, Emilie, Depoortere, Virginie, Michotte, Jean Bernard, Wittebole, Xavier, Jamar, François, REA‑RAISIN Studygroup, OUTCOMEREA study group, Sudden Death Expertise Center, for the HYPER2S Investigators and REVA research network, Clinical Research in Intensive Care and Sepsis (CRICS network), Cubrea network, and Brain Liver Pitié-Salpêtrière Study Group (BLIPS)

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2017
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36. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

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Hajage, David, primary, Combes, Alain, additional, Guervilly, Christophe, additional, Lebreton, Guillaume, additional, Mercat, Alain, additional, Pavot, Arthur, additional, Nseir, Saad, additional, Mekontso-Dessap, Armand, additional, Mongardon, Nicolas, additional, Mira, Jean Paul, additional, Ricard, Jean-Damien, additional, Beurton, Alexandra, additional, Tachon, Guillaume, additional, Kontar, Loay, additional, Le Terrier, Christophe, additional, Richard, Jean Christophe, additional, Mégarbane, Bruno, additional, Keogh, Ruth H., additional, Belot, Aurélien, additional, Maringe, Camille, additional, Leyrat, Clémence, additional, Schmidt, Matthieu, additional, Asfar, Pierre, additional, Beloncle, François, additional, Demiselle, Julien, additional, Pham, Tài, additional, Monnet, Xavier, additional, Richard, Christian, additional, Demoule, Alexandre, additional, Dres, Martin, additional, Mayaux, Julien, additional, Daubin, Cédric, additional, Descamps, Richard, additional, Joret, Aurélie, additional, Du Cheyron, Damien, additional, Pene, Frédéric, additional, Chiche, Jean-Daniel, additional, Jozwiak, Mathieu, additional, Jaubert, Paul, additional, Voiriot, Guillaume, additional, Fartoukh, Muriel, additional, Teulier, Marion, additional, Blayau, Clarisse, additional, L'Her, Erwen, additional, Aubron, Cécile, additional, Bodenes, Laetitia, additional, Ferriere, Nicolas, additional, Auchabie, Johann, additional, Le Meur, Anthony, additional, Pignal, Sylvain, additional, Mazzoni, Thierry, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Roudau, Jean-Baptiste, additional, Labruyère, Marie, additional, Preau, Sébastien, additional, Poissy, Julien, additional, Mathieu, Daniel, additional, Benhamida, Sarah, additional, Paulet, Rémi, additional, Roucaud, Nicolas, additional, Thyrault, Martial, additional, Daviet, Florence, additional, Hraiech, Sami, additional, Parzy, Gabriel, additional, Sylvestre, Aude, additional, Jochmans, Sébastien, additional, Bouilland, Anne-Laure, additional, Monchi, Mehran, additional, Danguy des Déserts, Marc, additional, Mathais, Quentin, additional, Rager, Gwendoline, additional, Pasquier, Pierre, additional, Reignier, Jean, additional, Seguin, Amélie, additional, Garret, Charlotte, additional, Canet, Emmanuel, additional, Dellamonica, Jean, additional, Saccheri, Clément, additional, Lombardi, Romain, additional, Kouchit, Yanis, additional, Jacquier, Sophie, additional, Mathonnet, Armelle, additional, Nay, Mai-Ahn, additional, Runge, Isabelle, additional, Martino, Frédéric, additional, Flurin, Laure, additional, Rolle, Amélie, additional, Carles, Michel, additional, Coudroy, Rémi, additional, W. Thille, Arnaud, additional, Frat, Jean-Pierre, additional, Rodriguez, Maeva, additional, Beuret, Pascal, additional, Tientcheu, Audrey, additional, Vincent, Arthur, additional, Michelin, Florian, additional, Tamion, Fabienne, additional, Carpentier, Dorothée, additional, Boyer, Déborah, additional, Beduneau, Gaetan, additional, Gissot, Valérie, additional, Ehrmann, Stéphan, additional, Salmon Gandonniere, Charlotte, additional, Elaroussi, Djlali, additional, Delbove, Agathe, additional, Fedun, Yannick, additional, Huntzinger, Julien, additional, Lebas, Eddy, additional, Kisoka, Grâce, additional, Grégoire, Céline, additional, Marchetta, Stella, additional, Lambermont, Bernard, additional, Argaud, Laurent, additional, Baudry, Thomas, additional, Bertrand, Pierre-Jean, additional, Dargent, Auguste, additional, Guitton, Christophe, additional, Chudeau, Nicolas, additional, Landais, Mickaël, additional, Darreau, Cédric, additional, Ferre, Alexis, additional, Gros, Antoine, additional, Lacave, Guillaume, additional, Bruneel, Fabrice, additional, Neuville, Mathilde, additional, Devaquet, Jérôme, additional, Gallot, Richard, additional, Chelha, Riad, additional, Galbois, Arnaud, additional, Jallot, Anne, additional, Chalumeau Lemoine, Ludivine, additional, Kuteifan, Khaldoun, additional, Pointurier, Valentin, additional, Jandeaux, Louise-Marie, additional, Mootien, Joy, additional, Damoisel, Charles, additional, Sztrymf, Benjamin, additional, Chommeloux, Juliette, additional, Edouard Luyt, Charles, additional, Schortgen, Frédérique, additional, Rusel, Leon, additional, Jung, Camille, additional, Gobert, Florent, additional, Vimpere, Damien, additional, Lamhaut, Lionel, additional, Sauneuf, Bertrand, additional, Charrrier, Liliane, additional, Calus, Julien, additional, Desmeules, Isabelle, additional, Painvin, Benoît, additional, Tadie, Jean-Marc, additional, Castelain, Vincent, additional, Michard, Baptiste, additional, Herbrecht, Jean-Etienne, additional, Baldacini, Mathieu, additional, Weiss, Nicolas, additional, Demeret, Sophie, additional, Marois, Clémence, additional, Rohaut, Benjamin, additional, Moury, Pierre-Henri, additional, Savida, Anne-Charlotte, additional, Couadau, Emmanuel, additional, Série, Mathieu, additional, Alexandru, Nica, additional, Bruel, Cédric, additional, Fontaine, Candice, additional, Garrigou, Sonia, additional, Courtiade Mahler, Juliette, additional, Leclerc, Maxime, additional, Ramakers, Michel, additional, Garçon, Pierre, additional, Massou, Nicole, additional, Van Vong, Ly, additional, Sen, Juliane, additional, Lucas, Nolwenn, additional, Chemouni, Franck, additional, Stoclin, Annabelle, additional, Avenel, Alexandre, additional, Faure, Henri, additional, Gentilhomme, Angélie, additional, Ricome, Sylvie, additional, Abraham, Paul, additional, Monard, Céline, additional, Textoris, Julien, additional, Rimmele, Thomas, additional, Montini, Florent, additional, Lejour, Gabriel, additional, Lazard, Thierry, additional, Etienney, Isabelle, additional, Kerroumi, Younes, additional, Dupuis, Claire, additional, Bereiziat, Marine, additional, Coupez, Elisabeth, additional, Thouy, François, additional, Hoffmann, Clément, additional, Donat, Nicolas, additional, Chrisment, Anne, additional, Blot, Rose-Marie, additional, Kimmoun, Antoine, additional, Jacquot, Audrey, additional, Mattei, Matthieu, additional, Levy, Bruno, additional, Ravan, Ramin, additional, Dopeux, Loïc, additional, Liteaudon, Jean-Mathias, additional, Roux, Delphine, additional, Rey, Brice, additional, Anghel, Radu, additional, Schenesse, Deborah, additional, Gevrey, Vincent, additional, Castanera, Jermy, additional, Petua, Philippe, additional, Madeux, Benjamin, additional, Hartman, Otto, additional, Piagnerelli, Michael, additional, Joosten, Anne, additional, Noel, Cinderella, additional, Biston, Patrick, additional, Noel, Thibaut, additional, LE Bouar, Gurvan, additional, Boukhanza, Messabi, additional, Demarest, Elsa, additional, Bajolet, Marie-France, additional, Charrier, Nathanaël, additional, Quenet, Audrey, additional, Zylberfajn, Cécile, additional, Dufour, Nicolas, additional, Mégarbane, Buno, additional, Voicu, Sébastian, additional, Deye, Nicolas, additional, Malissin, Isabelle, additional, Legay, François, additional, Debarre, Matthieu, additional, Barbarot, Nicolas, additional, Fillatre, Pierre, additional, Delord, Bertrand, additional, Laterrade, Thomas, additional, Saghi, Tahar, additional, Pujol, Wilfried, additional, Julien Cungi, Pierre, additional, Esnault, Pierre, additional, Cardinale, Mickael, additional, Hong Tuan Ha, Vivien, additional, Fleury, Grégory, additional, Brou, Marie-Ange, additional, Zafimahazo, Daniel, additional, Tran-Van, David, additional, Avargues, Patrick, additional, Carenco, Lisa, additional, Robin, Nicolas, additional, Ouali, Alexandre, additional, Houdou, Lucie, additional, Suh, Noémie, additional, Primmaz, Steve, additional, Pugin, Jérome, additional, Weiss, Emmanuel, additional, Gauss, Tobias, additional, Moyer, Jean-Denis, additional, Paugam Burtz, Catherine, additional, La Combe, Béatrice, additional, Smonig, Rolland, additional, Violleau, Jade, additional, Cailliez, Pauline, additional, Chelly, Jonathan, additional, Marchalot, Antoine, additional, Saladin, Cécile, additional, Bigot, Christelle, additional, Fayolle, Pierre-Marie, additional, Fatséas, Jules, additional, Ibrahim, Amr, additional, Resiere, Dabor, additional, Hage, Rabih, additional, Cholet, Clémentine, additional, Cantier, Marie, additional, Trouiler, Pierre, additional, Montravers, Philippe, additional, Lortat-Jacob, Brice, additional, Tanaka, Sebastien, additional, Tran Dinh, Alexy, additional, Duranteau, Jacques, additional, Harrois, Anatole, additional, Dubreuil, Guillaume, additional, Werner, Marie, additional, Godier, Anne, additional, Hamada, Sophie, additional, Zlotnik, Diane, additional, Nougue, Hélène, additional, Carteaux, Guillaume, additional, Razazi, Keyvan, additional, De Prost, Nicolas, additional, Lamraoui, Meriam, additional, Alessandri, Claire, additional, de Roux, Quentin, additional, de Roquetaillade, Charles, additional, G. Chousterman, Benjamin, additional, Mebazaa, Alexandre, additional, Gayat, Etienne, additional, Garnier, Marc, additional, Pardo, Emmanuel, additional, Satre-Buisson, Lea, additional, Gutton, Christophe, additional, Yvin, Elise, additional, Marcault, Clémence, additional, Azoulay, Elie, additional, Darmon, Michael, additional, Ait Oufella, Hafid, additional, Hariri, Geoffroy, additional, Urbina, Tomas, additional, Mazerand, Sandie, additional, Heming, Nicholas, additional, Santi, Francesca, additional, Moine, Pierre, additional, Annane, Djillali, additional, Bouglé, Adrien, additional, Omar, Edris, additional, Lancelot, Aymeric, additional, Begot, Emmanuelle, additional, Plantefeve, Gaétan, additional, Contou, Damien, additional, Mentec, Hervé, additional, Pajot, Olivier, additional, Faguer, Stanislas, additional, Cointault, Olivier, additional, Lavayssiere, Laurence, additional, Nogier, Marie-Béatrice, additional, Jamme, Matthieu, additional, Pichereau, Claire, additional, Hayon, Jan, additional, Outin, Hervé, additional, Dépret, François, additional, Coutrot, Maxime, additional, Chaussard, Maité, additional, Guillemet, Lucie, additional, Goffin, Pierre, additional, Thouny, Romain, additional, Guntz, Julien, additional, Jadot, Laurent, additional, Persichini, Romain, additional, Jean-Michel, Vanessa, additional, Georges, Hugues, additional, Caulier, Thomas, additional, Pradel, Gaël, additional, Hausermann, Marie-Hélène, additional, Nguyen-Valat, Thi My Hue, additional, Boudinaud, Michel, additional, Vivier, Emmanuel, additional, Rosseli, Sylvène, additional, Bourdin, Gaël, additional, Pommier, Christian, additional, Vinclair, Marc, additional, Poignant, Simon, additional, Mons, Sandrine, additional, Bougouin, Wulfran, additional, Bruna, Franklin, additional, Maestraggi, Quentin, additional, Roth, Christian, additional, Bitker, Laurent, additional, Dhelft, François, additional, Bonnet-Chateau, Justine, additional, Filippelli, Mathilde, additional, Morichau-Beauchant, Tristan, additional, Thierry, Stéphane, additional, Le Roy, Charlotte, additional, Saint Jouan, Mélanie, additional, Goncalves, Bruno, additional, Mazeraud, Aurélien, additional, Daniel, Matthieu, additional, Sharshar, Tarek, additional, Cadoz, Cyril, additional, Gaci, Rostane, additional, Gette, Sébastien, additional, Louis, Guillaune, additional, Sacleux, Sophe-Caroline, additional, Ordan, Marie-Amélie, additional, Cravoisy, Aurélie, additional, Conrad, Marie, additional, Courte, Guilhem, additional, Gibot, Sébastien, additional, Benzidi, Younès, additional, Casella, Claudia, additional, Serpin, Laurent, additional, Setti, Jean-Lou, additional, Besse, Marie-Catherine, additional, Bourreau, Anna, additional, Pillot, Jérôme, additional, Rivera, Caroline, additional, Vinclair, Camille, additional, Robaux, Marie-Aline, additional, Achino, Chloé, additional, Delignette, Marie-Charlotte, additional, Mazard, Tessa, additional, Aubrun, Frédéric, additional, Bouchet, Bruno, additional, Frérou, Aurélien, additional, Muller, Laura, additional, Quentin, Charlotte, additional, Degoul, Samuel, additional, Stihle, Xavier, additional, Sumian, Claude, additional, Bergero, Nicoletta, additional, Lanaspre, Bernard, additional, Quintard, Hervé, additional, Marie Maiziere, Eve, additional, Egreteau, Pierre-Yves, additional, Leloup, Guillaume, additional, Berteau, Florin, additional, Cottrel, Marjolaine, additional, Bouteloup, Marie, additional, Jeannot, Matthieu, additional, Blanc, Quentin, additional, Saison, Julien, additional, Geneau, Isabelle, additional, Grenot, Romaric, additional, Ouchike, Abdel, additional, Hazera, Pascal, additional, Masse, Anne-Lyse, additional, Demiri, Suela, additional, Vezinet, Corinne, additional, Baron, Elodie, additional, Benchetrit, Deborah, additional, Monsel, Antoine, additional, Trebbia, Grégoire, additional, Schaack, Emmanuelle, additional, Lepecq, Raphaël, additional, Bobet, Mathieu, additional, Vinsonneau, Christophe, additional, Dekeyser, Thibault, additional, Delforge, Quentin, additional, Rahmani, Imen, additional, Vivet, Bérengère, additional, Paillot, Jonathan, additional, Hierle, Lucie, additional, Chaignat, Claire, additional, Valette, Sarah, additional, Her, Benoït, additional, Brunet, Jennifier, additional, Page, Mathieu, additional, Boiste, Fabienne, additional, Collin, Anthony, additional, Bavozet, Florent, additional, Garin, Aude, additional, Dlala, Mohamed, additional, Mhamdi, Kais, additional, Beilouny, Bassem, additional, Lavalard, Alexandra, additional, Perez, Severine, additional, Veber, Benoit, additional, Guitard, Pierre-Gildas, additional, Gouin, Philippe, additional, Lamacz, Anna, additional, Plouvier, Fabienne, additional, P Delaborde, Bertrand, additional, Kherchache, Aïssa, additional, Chaalal, Amina, additional, Amouretti, Marc, additional, Freita-Ramos, Santiago, additional, Roux, Damien, additional, Constantin, Jean-Michel, additional, Assefi, Mona, additional, Lecore, Marine, additional, Selves, Agathe, additional, Prevost, Florian, additional, Lamer, Christian, additional, Shi, Ruiying, additional, Knani, Lyes, additional, Pili Floury, Sébastien, additional, Vettoretti, Lucie, additional, Levy, Michael, additional, Marsac, Lucile, additional, Dauger, Stéphane, additional, Guilmin-Crépon, Sophie, additional, Winiszewski, Hadrien, additional, Piton, Gael, additional, Soumagne, Thibaud, additional, Capellier, Gilles, additional, Putegnat, Jean-Baptiste, additional, Bayle, Frédérique, additional, Perrou, Maya, additional, Thao, Ghyslaine, additional, Géri, Guillaume, additional, Charron, Cyril, additional, Repessé, Xavier, additional, Vieillard-Baron, Antoine, additional, Guilbart, Mathieu, additional, Roger, Pierre-Alexandre, additional, Hinard, Sébastien, additional, Macq, Pierre-Yves, additional, Chaulier, Kevin, additional, Goutte, Sylvie, additional, Chillet, Patrick, additional, Pitta, Anaïs, additional, Darjent, Barbara, additional, Bruneau, Amandine, additional, Lasocki, Sigismond, additional, Leger, Maxime, additional, Gergaud, Soizic, additional, Lemarie, Pierre, additional, Terzi, Nicolas, additional, Schwebel, Carole, additional, Dartevel, Anaïs, additional, Galerneau, Louis-Marie, additional, Diehl, Jean-Luc, additional, Hauw-Berlemont, Caroline, additional, Péron, Nicolas, additional, Guérot, Emmanuel, additional, Mohebbi Amoli, Abolfazl, additional, Benhamou, Michel, additional, Deyme, Jean-Pierre, additional, Andremont, Olivier, additional, Lena, Diane, additional, Cady, Julien, additional, Causeret, Arnaud, additional, De La Chapelle, Arnaud, additional, Cracco, Christophe, additional, Rouleau, Stéphane, additional, Schnell, David, additional, Foucault, Camille, additional, Lory, Cécile, additional, Chapelle, Thibault, additional, Bruckert, Vincent, additional, Garcia, Julie, additional, Sahraoui, Abdlazize, additional, Abbosh, Nathalie, additional, Bornstain, Caroline, additional, Pernet, Pierre, additional, Poirson, Florent, additional, Pasem, Ahmed, additional, Karoubi, Philippe, additional, Poupinel, Virginie, additional, Gauthier, Caroline, additional, Bouniol, François, additional, Feuchere, Philippe, additional, Heron, Anne, additional, Carreira, Serge, additional, Emery, Malo, additional, Sophie Le Floch, Anne, additional, Giovannangeli, Luana, additional, Herzog, Nicolas, additional, Giacardi, Christophe, additional, Baudic, Thibaut, additional, Thill, Chloé, additional, Lebbah, Said, additional, Palmyre, Jessica, additional, Tubach, Florence, additional, Hajage, David, additional, Bonnet, Nicolas, additional, Ebstein, Nathan, additional, Gaudry, Stéphane, additional, Cohen, Yves, additional, Noublanche, Julie, additional, Lesieur, Olivier, additional, Sément, Arnaud, additional, Roca-Cerezo, Isabel, additional, Pascal, Michel, additional, Sma, Nesrine, additional, Colin, Gwenhaël, additional, Lacherade, Jean-Claude, additional, Bionz, Gauthier, additional, Maquigneau, Natacha, additional, Bouzat, Pierre, additional, Durand, Michel, additional, Hérault, Marie-Christine, additional, and Payen, Jean-Francois, additional

Published
2022
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38. Modulation by Polymyxin-B Hemoperfusion of Inflammatory Response Related to Severe Peritonitis

Author

Coudroy, Rémi, Payen, Didier, Launey, Yoann, Lukaszewicz, Anne-Claire, Kaaki, Mahmoud, Veber, Benoit, Collange, Olivier, Dewitte, Antoine, Martin-Lefevre, Laurent, Jabaudon, Matthieu, Kerforne, Thomas, Ferrandière, Martine, Kipnis, Eric, Vela, Carlos, Chevalier, Stéphanie, Mallat, Jihad, Charreau, Sandrine, Lecron, Jean-Claude, and Robert, René

Published
2017
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39. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial

Author

Payen, Didier M., Guilhot, Joelle, Launey, Yoann, Lukaszewicz, Anne Claire, Kaaki, Mahmoud, Veber, Benoit, and Pottecher, Julien

Subjects
Toray Industries Inc., Peritonitis -- Care and treatment -- Health aspects, Septic shock -- Care and treatment -- Health aspects, Health care industry
Abstract

Purpose To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections. Method Prospective, multicenter, randomized controlled trial in 18 French intensive care units from October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related to organ perforation. The PMX HP group received conventional therapy plus two sessions of PMX HP. Primary outcome was mortality on day 28; secondary outcomes were mortality on day 90 and a reduction in the severity of organ failures based on Sequential Organ Failure Assessment (SOFA) scores. Results Primary outcome: day 28 mortality in the PMX HP group (n = 119) was 27.7 versus 19.5 % in the conventional group (n = 113), p = 0.14 (OR 1.5872, 95 % CI 0.8583-2.935). Secondary endpoints: mortality rate at day 90 was 33.6 % in PMX-HP versus 24 % in conventional groups, p = 0.10 (OR 1.6128, 95 % CI 0.9067-2.8685); reduction in SOFA score from day 0 to day 7 was -5 (-11 to 6) in PMX-HP versus -5 (-11 to 9), p = 0.78. Comparable results were observed in the predefined subgroups (presence of comorbidity; adequacy of surgery, Conclusion This multicenter randomized controlled study demonstrated a non-significant increase in mortality and no improvement in organ failure with PMX HP treatment compared to conventional treatment of peritonitis-induced SS., Author(s): Didier M. Payen [sup.1] [sup.2], Joelle Guilhot [sup.3], Yoann Launey [sup.4], Anne Claire Lukaszewicz [sup.1] [sup.2], Mahmoud Kaaki [sup.5], Benoit Veber [sup.6], Julien Pottecher [sup.7], Olivier Joannes-Boyau [sup.8], Laurent [...]

Published
2015
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40. Risk factors for poor outcome in older patients admitted in a surgical intensive care unit.

Author

Occhiali, Emilie, Prolange, Pierre, Cassiau, Florence, Roca, Frédéric, Veber, Benoit, and Clavier, Thomas

Subjects
SURGERY & psychology, MORTALITY risk factors, INTENSIVE care units, LENGTH of stay in hospitals, STATISTICS, SCIENTIFIC observation, NUTRITIONAL assessment, FRAIL elderly, INTENSIVE care nursing, RESEARCH methodology, MULTIVARIATE analysis, PATIENTS, ACTIVITIES of daily living, TERTIARY care, MANN Whitney U Test, APACHE (Disease classification system), TREATMENT effectiveness, FUNCTIONAL assessment, PSYCHOLOGY of nurses, HOSPITAL care of older people, CRITICAL care medicine, QUALITY assurance, INTERPROFESSIONAL relations, DESCRIPTIVE statistics, CHI-squared test, LOGISTIC regression analysis, LONGITUDINAL method, PSYCHOLOGY of physicians
Abstract

Background: The benefit of a stay in an intensive care unit (ICU) is not certain for older patients, particularly in the surgical context. Aims: The objective of this study was to identify the factors associated with an unfavourable outcome in this population. Design: Prospective, descriptive, monocentric study conducted in the surgical ICU of a French university hospital. Methods: Patients aged ≥75 years admitted in the surgical ICU for a predicted length of stay ≥48 hours were included. Patients received an initial and a 6‐months nutritional and functional assessment performed by physicians and nurses. The outcome was considered as favourable if the Katz Activities of Daily Living (ADL) variation (ADL delta = 6‐months ADL – ICU admission ADL) was between 0 and −0.5 point 6 months after ICU discharge and unfavourable if the ADL delta decreased by more than 0.5 points or if the patient had died 6 months after ICU discharge. Results: Fifty‐six patients—32 (57%) male—aged 79 [77; 83] y were included. ICU mortality was 19%; 6‐month mortality was 22%. Median ADL delta was −0.5 [−0.5–0] points. A low ADL score (P =.0438) and a low albumin level (P =.0213) at admission were the two independent factors associated with an unfavourable outcome. Conclusion: Mortality and loss of independence were high in this elderly population during and after their surgical ICU stay. The benefit of a systematic collaboration between intensive care specialists, ICU nurses, and geriatricians, to assess and manage nutritional and functional problems and to prevent a pejorative outcome in patients over 75 years old admitted in surgical ICU needs to be studied. Relevance to clinical practice: There should be systematic screening for objective markers of undernutrition and frailty on ICU admission of older patients as they are associated with a poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Conflit en situation de limitation ou d’arrêt de traitement en réanimation

Author

Michel, Fabrice, primary, Claudot, Frédérique, additional, Veber, Benoit, additional, Brunel, Elodie, additional, Gateau, Valérie, additional, Guibet Lafaye, Caroline, additional, Kandelman, Stanislas, additional, Lallemant, Florence, additional, Le Boudec, Anne, additional, Ledorze, Matthieu, additional, Muller, Laurent, additional, Nouette-Gaulain, Karine, additional, Perrigault, Pierre-François, additional, Rutter, Nadège, additional, Samain, Emmanuel, additional, Visquesnel, Gérald, additional, and Zilberstein, Luca, additional

Published
2022
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44. Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study

Author

Massart, Nicolas, Maxime, Virginie, Fillatre, Pierre, Razazi, Keyvan, Ferré, Alexis, Moine, Pierre, Legay, Francois, Voiriot, Guillaume, Amara, Marlene, Santi, Francesca, Nseir, Saad, Marque-Juillet, Stephanie, Bounab, Rania, Barbarot, Nicolas, Bruneel, Fabrice, Luyt, Charles-Edouard, Mercat, Alain, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pham, Tài, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Demoule, Alexandre, Dres, Martin, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Fartoukh, Muriel, Teulier, Marion, Blayau, Clarisse, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Déserts, Marc Danguy Des, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Reignier, Jean, Seguin, Amélie, Garret, Charlotte, Canet, Emmanuel, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Girault, Christophe, Gissot, Valérie, Ehrmann, Stéphan, Gandonniere, Charlotte Salmon, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallo, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Lemoine, Ludivine Chalumeau, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Schmidt, Matthieu, Combes, Alain, Chommeloux, Juliette, Luyt, Charles Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Mahler, Juliette Courtiade, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Kimmoun, Antoine, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre Julien, Esnault, Pierre, Cardinale, Mickael, Ha, Vivien Hong Tuan, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Burtz, Catherine Paugam, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fayolle, Pierre-Marie, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Dinh, Alexy Tran, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, de Prost, Nicolas, Mongardon, Nicolas, Lamraoui, Meriam, Alessandri, Claire, de Roux, Quentin, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Oufella, Hafid Ait, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Jouan, Mélanie Saint, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Ricard, Jean-Damien, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Floury, Sébastien Pili, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Amoli, Abolfazl Mohebbi, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Lebbah, Said, Palmyre, Jessica, Tubach, Florence, Hajage, David, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Centre hospitalier Saint-Brieuc, Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CHU Henri Mondor [Créteil], Centre Hospitalier de Versailles André Mignot (CHV), CHU Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), INSERM UMRS-1144, Université Paris Cité, Réanimation Médicale et Toxicologique, Hôpital Lariboisière, COVID ICU Bacteremia Study Group on behalf of the COVID-ICU Investigators, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Henri Mondor, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN], and Mégarbane, Bruno

Subjects
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, RC86-88.9, Research, Correction, Medical emergencies. Critical care. Intensive care. First aid, bacterial infections and mycoses, Critical Care and Intensive Care Medicine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, human activities
Abstract

Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors and outcome of BSI in critically ill coronavirus infectious disease-19 (COVID-19) patients. Patients and methods We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU study) that included 4010 COVID-19 ICU patients. For the present analysis, only those with data regarding primary outcome (death within 90 days from admission) or BSI status were included. Risk factors for BSI were analyzed using Fine and Gray competing risk model. Then, for outcome comparison, 537 BSI-patients were matched with 537 controls using propensity score matching. Results Among 4010 included patients, 780 (19.5%) acquired a total of 1066 BSI (10.3 BSI per 1000 patients days at risk) of whom 92% were acquired in the ICU. Higher SAPS II, male gender, longer time from hospital to ICU admission and antiviral drug before admission were independently associated with an increased risk of BSI, and interestingly, this risk decreased over time. BSI was independently associated with a shorter time to death in the overall population (adjusted hazard ratio (aHR) 1.28, 95% CI 1.05–1.56) and, in the propensity score matched data set, patients with BSI had a higher mortality rate (39% vs 33% p = 0.036). BSI accounted for 3.6% of the death of the overall population. Conclusion COVID-19 ICU patients have a high risk of BSI, especially early after ICU admission, risk that increases with severity but not with corticosteroids use. BSI is associated with an increased mortality rate.

Published
2021

45. Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals

Author

Schmidt, Matthieu, Demoule, Alexandre, Hajage, David, Pham, Tài, Combes, Alain, Dres, Martin, Lebbah, Said, Kimmoun, Antoine, Mercat, Alain, Beduneau, Gaëtan, Palmyre, Jessica, Prevost, Margot, Ricard, Jean-Damien, Ferré, Alexis, Fayolle, Pierre-Marie, Girault, Christophe, Pradel, Gael, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Voiriot, Guillaume, Fartoukh, Muriel, Teulier, Marion, Blayau, Clarisse, L’her, Erwen, Aubron, Cécile, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Nseir, Saad, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Des Déserts, Marc Danguy, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Jean, Reignier, Amélie, Seguin, Charlotte, Garret, Emmanuel, Canet, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Gissot, Valérie, Ehrmann, Stéphan, Gandonniere, Charlotte Salmon, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Bruneel, Fabrice, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallot, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Lemoine, Ludivine Chalumeau, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Chommeloux, Juliette, Luyt, Charles Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Mahler, Juliette Courtiade, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sqébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Barbarot, Nicolas, Fillatre, Pierre, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre Julien, Esnault, Pierre, Cardinale, Mickael, Ha, Vivien Hong Tuan, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Burtz, Catherine Paugam, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Dinh, Alexy Tran, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, Razazi, Keyvan, de Prost, Nicolas, Mongardon, Nicolas, Langeron, Olivier, Levesque, Eric, Attias, Arié, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Oufella, Hafid Ait, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Santi, Francesca, Moine, Pierre, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Jouan, Mélanie Saint, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Floury, Sébastien Pili, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Amoli, Abolfazl Mohebbi, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Tubach, Florence, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), COVID-ICU group, for the REVA network, COVID-ICU investigators, and Mégarbane, Bruno

Subjects
Critical Care and Intensive Care Medicine, Acute respiratory failure, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Risk Assessment, Mechanical ventilation, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, Prospective Studies, Mortality, Outcome, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Noninvasive Ventilation, Acute respiratory distress syndrome, RC86-88.9, Research, COVID-19, Medical emergencies. Critical care. Intensive care. First aid, Hospitals, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Intensive Care Units, [SDV.TOX]Life Sciences [q-bio]/Toxicology, High-flow nasal cannula, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Intubation
Abstract

Rational To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care units (ICUs). Methods Multicenter, prospective cohort study (COVID-ICU) in 137 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, oxygenation failure, and survival data were collected. Oxygenation failure was defined as either intubation or death in the ICU without intubation. Variables independently associated with oxygenation failure and Day-90 mortality were assessed using multivariate logistic regression. Results From February 25 to May 4, 2020, 4754 patients were admitted in ICU. Of these, 1491 patients were not intubated on the day of ICU admission and received standard oxygen therapy (51%), HFNC (38%), or NIV (11%) (P P P = 0.013) but not NIV (OR 1.57, 95% CI 0.78–3.21) was associated with a reduction in oxygenation failure). Overall 90-day mortality was 21%. By multivariable analysis, HFNC was not associated with a change in mortality (OR 0.90, 95% CI 0.61–1.33), while NIV was associated with increased mortality (OR 2.75, 95% CI 1.79–4.21, P Conclusion In patients with COVID-19, HFNC was associated with a reduction in oxygenation failure without improvement in 90-day mortality, whereas NIV was associated with a higher mortality in these patients. Randomized controlled trials are needed.

Published
2021

48. Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores

Author

Schmidt, Matthieu, Guidet, Bertrand, Demoule, Alexandre, Ponnaiah, Maharajah, Fartoukh, Muriel, Puybasset, Louis, Combes, Alain, Hajage, David, Mercat, Alain, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pham, Tài, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Dres, Martin, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Voiriot, Guillaume, Teulier, Marion, Blayau, Clarisse, L’her, Erwen, Aubron, Cécile, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Nseir, Saad, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Danguy Des Déserts, Marc, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Jean, Reignier, Amélie, Seguin, Charlotte, Garret, Emmanuel, Canet, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Girault, Christophe, Gissot, Valérie, Ehrmann, Stéphan, Salmon Gandonniere, Charlotte, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Bruneel, Fabrice, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallot, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Chalumeau Lemoine, Ludivine, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Chommeloux, Juliette, Luyt, Charles-Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Courtiade Mahler, Juliette, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Kimmoun, Antoine, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sqébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Barbarot, Nicolas, Fillatre, Pierre, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre-Julien, Esnault, Pierre, Cardinale, Mickael, Hong Tuan Ha, Vivien, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Paugam Burtz, Catherine, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fayolle, Pierre-Marie, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Tran Dinh, Alexy, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, Razazi, Keyvan, de Prost, Nicolas, Mongardon, Nicolas, Langeron, Olivier, Levesque, Eric, Attias, Arié, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Ait Oufella, Hafid, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Santi, Francesca, Moine, Pierre, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Saint Jouan, Mélanie, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Ricard, Jean-Damien, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Pili Floury, Sébastien, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Mohebbi Amoli, Abolfazl, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Lebbah, Said, Palmyre, Jessica, Tubach, Florence, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aigüE [CHU Pitié-Salpêtrière] (GRC RESPIRE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Département Médico-Universitaire APPROCHES, CHU Tenon [AP-HP], Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Henri Mondor, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Pharmacoépidémiologie de l'AP-HP (Cephepi), INSERM UMRS-1144, Université Paris Cité, Réanimation Médicale et Toxicologique, Hôpital Lariboisière, and Mégarbane, Bruno

Subjects
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Acute respiratory distress syndrome, RC86-88.9, Research, COVID-19, Medical emergencies. Critical care. Intensive care. First aid, Critical Care and Intensive Care Medicine, Predictive survival model, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Mechanical ventilation, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Outcome
Abstract

Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7’s area under the ROC curve was slightly higher (0.80 [0.74–0.86]) than those for SOSIC-1 (0.76 [0.71–0.81]) and SOSIC-14 (0.76 [0.68–0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis.

Published
2021

50. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

Author

Bouadma, Lila, Luyt, Charles-Edouard, Tubach, Florence, Cracco, Christophe, Alvarez, Antonio, Schwebel, Carole, Schortgen, Frédérique, Lasocki, Sigismond, Veber, Benoît, Dehoux, Monique, Bernard, Maguy, Pasquet, Blandine, Régnier, Bernard, Brun-Buisson, Christian, Chastre, Jean, and Wolff, Michel

Published
2010
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