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394 results on '"Vecsei, Laszlo"'

9. Memantine for Treatment of Dementia

Author

Müller, Thomas, Kuhn, Wilfried, Vécsei, László, Section editor, Riederer, Peter, editor, Laux, Gerd, editor, Nagatsu, Toshiharu, editor, Le, Weidong, editor, and Riederer, Christian, editor

Published
2022
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11. Anti-dementia Medications: Specific Agents

Author

Zhang, Feng, Liu, Xinyao, Liu, Yufei, Wang, Yanjiang, Le, Weidong, Vecsei, Laszlo, Section editor, Riederer, Peter, editor, Laux, Gerd, editor, Nagatsu, Toshiharu, editor, Le, Weidong, editor, and Riederer, Christian, editor

Published
2022
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12. Real-world operation of multiple sclerosis centres in Central-Eastern European countries covering 107 million inhabitants

Author

Kokas, Zsófia, Járdánházy, Anett, Sandi, Dániel, Biernacki, Tamás, Fricska-Nagy, Zsanett, Füvesi, Judit, Bartosik-Psujek, Halina, Kes, Vanja Basic, Berger, Thomas, Berthele, Achim, Drulovic, Jelena, Hemmer, Bernhard, Horakova, Dana, Ledinek, Alenka Horvat, Havrdova, Eva Kubala, Magyari, Melinda, Rejdak, Konrad, Tiu, Cristina, Turcani, Peter, Klivényi, Péter, Kincses, Zsigmond Tamás, Vécsei, László, and Bencsik, Krisztina

Published
2023
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17. Pituitary cyclase‐activating polypeptide targeted treatments for the treatment of primary headache disorders.

Author

Karsan, Nazia, Edvinsson, Lars, Vecsei, Laszlo, and Goadsby, Peter J

Subjects
PRIMARY headache disorders, PITUITARY adenylate cyclase activating polypeptide, CALCITONIN gene-related peptide, CYCLIC adenylic acid, VASOACTIVE intestinal peptide
Abstract

Objective: Migraine is a complex and disabling neurological disorder. Recent years have witnessed the development and emergence of novel treatments for the condition, namely those targeting calcitonin gene‐related peptide (CGRP). However, there remains a substantial need for further treatments for those unresponsive to current therapies. Targeting pituitary adenylate cyclase‐activating polypeptide (PACAP) as a possible therapeutic strategy in the primary headache disorders has gained interest over recent years. Methods: This review will summarize what we know about PACAP to date: its expression, receptors, roles in migraine and cluster headache biology, insights gained from preclinical and clinical models of migraine, and therapeutic scope. Results: PACAP shares homology with vasoactive intestinal polypeptide (VIP) and is one of several vasoactive neuropeptides along with CGRP and VIP, which has been implicated in migraine neurobiology. PACAP is widely expressed in areas of interest in migraine pathophysiology, such as the thalamus, trigeminal nucleus caudalis, and sphenopalatine ganglion. Preclinical evidence suggests a role for PACAP in trigeminovascular sensitization, while clinical evidence shows ictal release of PACAP in migraine and intravenous infusion of PACAP triggering attacks in susceptible individuals. PACAP leads to dural vasodilatation and secondary central phenomena via its binding to different G‐protein‐coupled receptors, and intracellular downstream effects through cyclic adenosine monophosphate (cAMP) and phosphokinase C (PKC). Targeting PACAP as a therapeutic strategy in headache has been explored using monoclonal antibodies developed against PACAP and against the PAC1 receptor, with initial positive results. Interpretation: Future clinical trials hold considerable promise for a new therapeutic approach using PACAP‐targeted therapies in both migraine and cluster headache. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial

Author

ALTHAUS, Katharina, AMARO, Sergi, BAE, Hee-Joon, BAK, Zbigniew, BARBARINI, Leonardo, BASSI, Pietro, BAZAN, Rodrigo, BERECZKI, Daniel, BERKOWICZ, Tomasz, BERROUSCHOT, Joerg, BLACQUIERE, Dylan, BROLA, Waldemar, BUTCHER, Kenneth, CARDONA, Pere, CHA, Jae-Kwan, CLOUD, Geoffrey, COHEN, David, CORDONNIER, Charlotte, CSANYI, Attila, CZLONKOWSKA, Anna, DAVIS, Stephen, DAWSON, Jesse, DE KLIPPEL, Nina, DENIER, Christian, DESFONTAINES, Philippe, DIENER, Hans-Christoph, DIOSZEGHY, Peter, DIPPEL, Diederik Willem, DORADO, Laura, FOLYOVICH, Andras, FREITAS, Gabriel Rodriguez, FRIEDRICH, Mauricio Andre, FRYZE, Waldemar, GAGLIARDI, Rubens Jose, GOTTSCHAL, Marianna, GRIMLEY, Rohan, GROND, Martin, GRÖSCHEL, Klaus, HOSSEINI, Hassan, HWANG, Yangha, KALLMUENZER, Bernd, KHAN, Usman, KIM, Jong Sung, KLEINIG, Tim, KOVES, Agnes, LAGO MARTIN, Aida, LASEK-BAL, Anetta, LEMBO, Giuseppe, LEMMENS, Robin, LINDERT, Ralf, PORCELLO MARRONE, Luiz Carlos, MARTINEZ ZABALETA, Maite, MAS, Jean-Louis, MASJUAN VALLEJO, Jaime, MAZIGHI, Mikael, MINELLI, Cesar, MISTRI, Amit, MOLINA, Carlos, MONICHE ALVAREZ, Francisco, CABRAL MORO, Carla Heloisa, MULLENERS, Wim, NABAVI, Darius, NEAU, Jean-Philippe, O'BRIEN, Bill, OVARY, Csaba, PANCZEL, Gyula, PARK, Man Seok, PHAN, Thanh, RAGAB, Suzanne, REJDAK, Konrad, RODRIGUEZ DE FREITAS, Gabriel, ROFFE, Christine, ROQUER GONZALEZ, Jaume, ROVER, Luisa, SAMPAIO SILVA, Gisele, SCHELLINGER, Peter, SEGURA MARTIN, Tomas, SHAW, Louise, SIBON, Igor, SKODA, Ondrej, SMADJA, Didier, SOBOLEWSKI, Piotr, SODA, Hassan, SPRIGG, Nikola, SWIAT, Maciej, SZAPARY, Laszlo, SZEGEDI, Norbert, TONI, Danilo, VALIKOVICS, Attila, VANHOOREN, Geert, VECSEI, Laszlo, WEIN, Theodore, WONG, Andrew, XIMENEZ CARRILLO, Alvaro, Chabriat, Hugues, Bassetti, Claudio L, Marx, Ute, Audoli-Inthavong, Marie-Laure, Sors, Aurore, Lambert, Estelle, Wattez, Marine, and Hermann, Dirk M

Published
2020
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23. Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial

Author

Agüera Morales, Eduardo, Al Khedr, Abdullatif, Ampapa, Radek, Arroyo, Rafael, Belkin, Martin, Bonek, Robert, Boyko, Alexey, Capra, Ruggero, Centonze, Diego, Clavelou, Pierre, Debouverie, Marc, Drulovic, Jelena, Edwards, Keith, Evangelou, Nikos, Evdoshenko, Evgeniy, Fernández, Oscar, Fernández Sánchez, Victoria, Freedman, Mark, Freedman, Steven, Fryze, Waldemar, Garcia-Merino, Antonio, Gavric-Kezic, Mira, Ghezzi, Angel, Gout, Olivier, Grimaldi, Luigi, Hendin, Barry, Hertmanowska, Hanka, Hintzen, Rogier, Hradilek, Pavel, Hupperts, Raymond, Ilkowski, Jan, Ivashinenkova, Evelina, Izquierdo, Guillermo, Jacques, Francois, Jakab, Gabor, Khabirov, Farit, Klodowska-Duda, Gabriela, Komoly, Samuel, Kostic, Smiljana, Kovarova, Ivana, Kremenchuzky, Marcelo, Laganke, Christopher, LaPierre, Yves, Maciejowski, Maciej, Maison, Francois Grand, Marfia, Girolama Alessandra, Martínez Yélamos, Sergio, Meluzinova, Eva, Montalban, Xavier, Murray, Ronald, Naismith, Robert, Newsome, Scott, Nguyen, Viet, Oreja, Delia, Pardo, Gabriel, Pasechnik, Elena, Patti, Francesco, Potemkowski, Andrzej, Prokopenko, Semen, Qian, Peiqing, Rodríguez-Antigüedad, Alfredo, Rossman, Howard, Rozsa, Csilla, Sánchez López, Fernando, Selmaj, Krzysztof, Silber, Eli, Stepien, Adam, Stepniewska, Anna, Swiat, Maciej, Toncev, Gordana, Tourbah, Ayman, Trushnikova, Tatyana, Uccelli, Antonio, Vachova, Marta, Valis, Martin, Vecsei, Laszlo, Wiertlewski, Sandrine, Zaffaroni, Mauro, Zielinski, Tomasz, Cadavid, Diego, Mellion, Michelle, Edwards, Keith R, Calabresi, Peter A, Drulović, Jelena, Giovannoni, Gavin, Hartung, Hans-Peter, Arnold, Douglas L, Fisher, Elizabeth, Rudick, Richard, Mi, Sha, Chai, Yi, Li, Jie, Zhang, Yiwei, Cheng, Wenting, Xu, Lei, Zhu, Bing, Green, Susan M, Chang, Ih, Deykin, Aaron, and Sheikh, Sarah I

Published
2019
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30. Levodopa/carbidopa intestinal gel can improve both motor and non-motor experiences of daily living in Parkinson’s disease: An open-label study

Author

Juhász, Annamária, Aschermann, Zsuzsanna, Ács, Péter, Janszky, József, Kovács, Márton, Makkos, Attila, Harmat, Márk, Tényi, Dalma, Karádi, Kázmér, Komoly, Sámuel, Takáts, Annamária, Tóth, Adrián, Nagy, Helga, Klivényi, Péter, Dibó, György, Dézsi, Lívia, Zádori, Dénes, Annus, Ádám, Vécsei, László, Varannai, Lajos, and Kovács, Norbert

Published
2017
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41. Language Deficits in Pre-Symptomatic Huntington's Disease: Evidence from Hungarian

Author

Nemeth, Dezso, Dye, Cristina D., Sefcsik, Tamas, Janacsek, Karolina, Turi, Zsolt, Londe, Zsuzsa, Klivenyi, Peter, Kincses, Zsigmond Tamas, Szabo, Nikoletta, Vecsei, Laszlo, and Ullman, Michael T.

Abstract

A limited number of studies have investigated language in Huntington's disease (HD). These have generally reported abnormalities in rule-governed (grammatical) aspects of language, in both syntax and morphology. Several studies of verbal inflectional morphology in English and French have reported evidence of over-active rule processing, such as over-suffixation errors (e.g., walkeded) and over-regularizations (e.g., digged). Here we extend the investigation to noun inflection in Hungarian, a Finno-Ugric agglutinative language with complex morphology, and to genetically proven pre-symptomatic Huntington's disease (pre-HD). Although individuals with pre-HD have no clinical, motor or cognitive symptoms, the underlying pathology may already have begun, and thus sensitive behavioral measures might reveal already-present impairments. Indeed, in a Hungarian morphology production task, pre-HD patients made both over-suffixation and over-regularization errors. The findings suggest the generality of over-active rule processing in both HD and pre-HD, across languages from different families with different morphological systems, and for both verbal and noun inflection. Because the neuropathology in pre-HD appears to be largely restricted to the caudate nucleus and related structures, the findings further implicate these structures in language, and in rule-processing in particular. Finally, the need for effective treatments in HD, which will likely depend in part on the ability to sensitively measure early changes in the disease, suggests the possibility that inflectional morphology, and perhaps other language measures, may provide useful diagnostic, tracking, and therapeutic tools for assessing and treating early degeneration in pre-HD and HD. (Contains 2 tables and 1 figure.)

Published
2012
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43. CSF biomarker variability in the Alzheimer's Association quality control program

Author

Rojo, Aladro José A., Albert, Marilyn, Alcolea, Daniel, Andreasson, Ulf, Antonell, Anna, Arai, Hiroyuki, Archetti, Silvana, Arkblad, Eva, Baldeiras, Inês, Bartos, Ales, Batish, Dev, Bedel, Aurélie, Bentue-Ferrer, Daniele, Berisha, Flora, Bernardini, Sergio, Blankenstein, Marinus, Blennow, Kaj, Bousiges, Olivier, Camuso, Michael C., Carrillo, Maria, Casoli, Tiziana, Cavallaro, Sebastiano, Chalbot, Sonia, Collins, Steven, Cruz e Silva, Odete, Cutler, Neal, Cuvelier, Isabelle, Delaroche, Odile, Dufour-Rainfray, Diane, Dyer, Roy, Engelborghs, Sebastiaan, Fagan, Anne M., Fogli, Anne, Forlenza, Orestes V., Fox, Nick, Frisoni, Giovanni, Galimberti, Daniela, Galloni, Elisabetta, Gritti, Silvana, Gylys, Karen H., Hampel, Harald, Haustein, Sabine, Heath, Theresa, Heegaard, Niels H.H., Heneka, Michael T., Herukka, Sanna-Kaisa, Holtzman, David, Hsiung, Ging-Yuek Robin, Humpel, Christian, Hyman, Bradley, Iwatsubo, Takeshi, Iqbal, Khalid, Jardel, Claude, Jucker, Mathias, Kapaki, Elisabeth, Käser, Stephan A., Kidd, Daniel, Klivenyi, Peter, Kuwano, Ryozo, Lachno, D. Richard, Lamari, Foudil, Laplanche, Jean-Louis, Laser, Jordan, Lehmann, Sylvian, Lewczuk, Piotr, Li, Qiao-Xin, Lleó, Alberto, Maetzler, Walter, Malaplate-Armand, Catherine, Martin, Ralph, Martone, Robert L., Masters, Colin, Mattsson, Niklas, Mercken, Marc, Molinuevo, José Luis, Montine, Tom, Nowatzke, William, Otto, Markus, Parchi, Piero, Parent, Xavier, Parnetti, Lucilla, Persson, Staffan, Petersen, Ronald, Poesen, Koen, Quadrio, Isabelle, Quillard, Muriel, Regeniter, Axel, Rello, Vara Luis, Rissman, Robert, Rohan, Zdenek, Rosenmann, Hanna, Sancesario, Giuseppe, Schröder, Johannes, Shaw, Leslie M., Sisowath, Christin, Skinningsrud, Anders, Soares, Holly, Soininen, Hilkka, Søndersø, Knudsen Cindy, Spreer, Annette, Suardi, Silvia, Teunissen, Charlotte, Trojanowski, John Q., Umek, Robert, Van Broeck, Bianca, Vandenberghe, Rik, Vanderstichele, Hugo, Vandijck, Manu, Vecsei, Laszlo, Verbeek, Marcel, Vostiar, Igor, Windisch, Manfred, Zetterberg, Henrik, Carrillo, Maria C., Robin Hsiung, Ging-Yuek, Molinuevo, José L., Teunissen, Charlotte E., and Verbeek, Marcel M.

Published
2013
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50. The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers

Author

Mattsson, Niklas, Andreasson, Ulf, Persson, Staffan, Arai, Hiroyuki, Batish, Sat Dev, Bernardini, Sergio, Bocchio-Chiavetto, Luisella, Blankenstein, Marinus A., Carrillo, Maria C., Chalbot, Sonia, Coart, Els, Chiasserini, Davide, Cutler, Neal, Dahlfors, Gunilla, Duller, Stefan, Fagan, Anne M., Forlenza, Orestes, Frisoni, Giovanni B., Galasko, Douglas, Galimberti, Daniela, Hampel, Harald, Handberg, Aase, Heneka, Michael T., Herskovits, Adrianna Z., Herukka, Sanna-Kaisa, Holtzman, David M., Humpel, Christian, Hyman, Bradley T., Iqbal, Khalid, Jucker, Mathias, Kaeser, Stephan A., Kaiser, Elmar, Kapaki, Elisabeth, Kidd, Daniel, Klivenyi, Peter, Knudsen, Cindy S., Kummer, Markus P., Lui, James, Lladó, Albert, Lewczuk, Piotr, Li, Qiao-Xin, Martins, Ralph, Masters, Colin, McAuliffe, John, Mercken, Marc, Moghekar, Abhay, Molinuevo, José Luis, Montine, Thomas J., Nowatzke, William, O’Brien, Richard, Otto, Markus, Paraskevas, George P., Parnetti, Lucilla, Petersen, Ronald C., Prvulovic, David, de Reus, Herman P.M., Rissman, Robert A., Scarpini, Elio, Stefani, Alessandro, Soininen, Hilkka, Schröder, Johannes, Shaw, Leslie M., Skinningsrud, Anders, Skrogstad, Brith, Spreer, Annette, Talib, Leda, Teunissen, Charlotte, Trojanowski, John Q., Tumani, Hayrettin, Umek, Robert M., Van Broeck, Bianca, Vanderstichele, Hugo, Vecsei, Laszlo, Verbeek, Marcel M., Windisch, Manfred, Zhang, Jing, Zetterberg, Henrik, and Blennow, Kaj

Published
2011
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