Search

Your search keyword '"Veenstra, Rachelle G."' showing total 11 results
Start Over Author "Veenstra, Rachelle G."
11 results on '"Veenstra, Rachelle G."'

1. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Author

Veenstra, Rachelle G., Flynn, Ryan, Kreymborg, Katharina, McDonald-Hyman, Cameron, Saha, Asim, Taylor, Patricia A., Osborn, Mark J., Panoskaltsis-Mortari, Angela, Schmitt-Graeff, Annette, Lieberknecht, Elisabeth, Murphy, William J., Serody, Jonathan S., Munn, David H., Freeman, Gordon J., Allison, James P., Mak, Tak W., van den Brink, Marcel, Zeiser, Robert, and Blazar, Bruce R.

Published
2015
Full Text
View/download PDF

2. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Author

Saha, Asim, Aoyama, Kazutoshi, Taylor, Patricia A., Koehn, Brent H., Veenstra, Rachelle G., Panoskaltsis-Mortari, Angela, Munn, David H., Murphy, William J., Azuma, Miyuki, Yagita, Hideo, Fife, Brian T., Sayegh, Mohammed H., Najafian, Nader, Socie, Gerard, Ahmed, Rafi, Freeman, Gordon J., Sharpe, Arlene H., and Blazar, Bruce R.

Published
2013
Full Text
View/download PDF

3. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

Author

Aoyama, Kazutoshi, Saha, Asim, Tolar, Jakub, Riddle, Megan J., Veenstra, Rachelle G., Taylor, Patricia A., Blomhoff, Rune, Panoskaltsis-Mortari, Angela, Klebanoff, Christopher A., Socié, Gérard, Munn, David H., Murphy, William J., Serody, Jonathan S., Fulton, LeShara M., Teshima, Takanori, Chandraratna, Roshantha A., Dmitrovsky, Ethan, Guo, Yanxia, Noelle, Randolph J., and Blazar, Bruce R.

Published
2013
Full Text
View/download PDF

6. Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Author

Flynn, Ryan, primary, Du, Jing, additional, Veenstra, Rachelle G., additional, Reichenbach, Dawn K., additional, Panoskaltsis-Mortari, Angela, additional, Taylor, Patricia A., additional, Freeman, Gordon J., additional, Serody, Jonathan S., additional, Murphy, William J., additional, Munn, David H., additional, Sarantopoulos, Stefanie, additional, Luznik, Leo, additional, Maillard, Ivan, additional, Koreth, John, additional, Cutler, Corey, additional, Soiffer, Robert J., additional, Antin, Joseph H., additional, Ritz, Jerome, additional, Dubovsky, Jason A., additional, Byrd, John C., additional, MacDonald, Kelli P., additional, Hill, Geoff R., additional, and Blazar, Bruce R., additional

Published
2014
Full Text
View/download PDF

7. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells

Author

Guimond, Martin, primary, Veenstra, Rachelle G, additional, Grindler, David J, additional, Zhang, Hua, additional, Cui, Yongzhi, additional, Murphy, Ryan D, additional, Kim, Su Young, additional, Na, Risu, additional, Hennighausen, Lothar, additional, Kurtulus, Sema, additional, Erman, Batu, additional, Matzinger, Polly, additional, Merchant, Melinda S, additional, and Mackall, Crystal L, additional

Published
2009
Full Text
View/download PDF

10. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

Author

Guimond, Martin, Veenstra, Rachelle G, Grindler, David J, Zhang, Hua, Cui, Yongzhi, Murphy, Ryan D, Kim, Su Young, Na, Risu, Hennighausen, Lothar, Kurtulus, Sema, Erman, Batu, Matzinger, Polly, Merchant, Melinda S, and Mackall, Crystal L

Abstract

Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4+ T cells undergo less-efficient homeostatic proliferation than CD8+ T cells do. Here we show that systemic IL-7 concentrations increased during lymphopenia because of diminished use of IL-7 but that IL-7 signaling on IL-7 receptor-α–positive (IL-7Rα+) dendritic cells (DCs) in lymphopenic settings paradoxically diminished the homeostatic proliferation of CD4+ T cells. This effect was mediated at least in part by IL-7-mediated downregulation of the expression of major histocompatibility complex class II on IL-7Rα+ DCs. Our results indicate that IL-7Rα+ DCs are regulators of the peripheral CD4+ T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4+ T cell population expansion in vivo. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

11. Coexpression of Tim-3 and PD-1 identifies a CD8+T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Author

Zhou, Qing, Munger, Meghan E., Veenstra, Rachelle G., Weigel, Brenda J., Hirashima, Mitsuomi, Munn, David H., Murphy, William J., Azuma, Miyuki, Anderson, Ana C., Kuchroo, Vijay K., and Blazar, Bruce R.

Abstract

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8+T cells in the liver, the major first site of AML metastases. PD-1 and Tim-3 coexpression increased during AML progression. PD-1+Tim-3+CD8+T cells were deficient in their ability to produce IFN-γ, TNF-α, and IL-2 in response to PD-1 ligand (PDL1) and Tim-3 ligand (galectin-9) expressing AML cells. PD-1 knockout (KO), which were partially resistant to AML challenge, up-regulated Tim-3 during AML progression and such Tim-3+PD-1- KO CD8+T cells had reduced cytokine production. Galectin-9 KO mice were more resistant to AML, which was associated with reduced T-regulatory cell accumulation and a modest induction of PD-1 and Tim-3 expression on CD8+T cells. Whereas blocking the PD-1/PDL1 or Tim-3/galectin-9 pathway alone was insufficient to rescue mice from AML lethality, an additive effect was seen in reducing—albeit not eliminating—both tumor burden and lethality when both pathways were blocked. Therefore, combined PD-1/PDL1 and Tim-3/galectin-9 blockade may be beneficial in preventing CD8+T-cell exhaustion in patients with hematologic malignancies such as advanced AML.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results