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1. A Characteristics Approach to the Finite Element Method.

Author

Lam, Adam Q. and Vega, Richard M.

Abstract

AbstractWe present a new method for solving the linear Boltzmann transport equation. Two commonly used and well-understood methods for solving partial differential equations are the method of characteristics (MOC) and the finite element method (FEM). We propose a new method that combines the fundamental concept of the FEM with the analytic solution from the MOC to obtain coefficients for the FEM basis function expansion. Traditionally, coefficients for the FEM basis function expansion are obtained via matrix inversion. Instead, we solve for the coefficients with the MOC and represent the underlying fields with the basis function expansion using these coefficients. We provide a convergence study for our method with results from two sets of FEM basis functions: Gauss-Legendre and Gauss-Lobatto sets. We also compare two different variations of our method categorized as short characteristics and intermediate characteristics. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Propuesta de integración curricular de la aplicación educativa 'SIAPP' como recurso de apoyo en la asignatura Ciencias Naturales de 9no grado de educación media, en la unidad IV: Sistema Internacional de medidas y sus unidades derivadas

Author

Rayo García, Francisco José, Hernández Vega, Richard Antonio, and Herrera Muñoz, Eyner Yamil

Subjects
500 Ciencias naturales y matemáticas, 003 Sistemas, 371.3 Didáctica y Pedagogía
Abstract

Teniendo en cuenta la importancia que es el tema por el cual hemos desarrollado el presente documento que consiste en una propuesta de integración curricular para el reforzamiento de la asignatura de Ciencias Naturales de 9no grado de educación media, en la unidad IV: Sistema Internacional de medida y sus unidades derivadas. Mediante la aplicación “SIAPP” desarrollaremos los conceptos del Sistema de medida Internacional, conceptos que ayudaran a los estudiantes a desarrollar su compresión sobre el SI (Sistema Internacional de Medida) además de realizar diferentes ejercicios que los ayudaran a afianzar sus conocimientos. Como estudiantes de Informática Educativa de la UNAN-MANAGUA les dejamos un tema sumamente importante y poco abordado que les servirá de gran ayuda y esperamos sepan aprovecharlo para un buen uso

Published
2022

8. Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds

Author

Gibbs, Richard A., Taylor, Jeremy F., Van Tassell, Curtis P., Barendse, William, Eversole, Kellye A., Gibbs, Richard A., Gill, Clare A., Green, Ronnie D., Hamernik, Debora L., Kappes, Steven M., Lien, Sigbjørn, Matukumalli, Lakshmi K., McEwan, John C., Nazareth, Lynne V., Schnabel, Robert D., Taylor, Jeremy F., Van Tassell, Curtis P., Weinstock, George M., Wheeler, David A., Ajmone-Marsan, Paolo, Barendse, William, Boettcher, Paul J., Caetano, Alexandre R., Fernando Garcia, Jose, Gill, Clare A., Green, Ronnie D., Hanotte, Olivier, Lien, Sigbjørn, Mariani, Paola, McEwan, John C., Skow, Loren C., Sonstegard, Tad S., Van Tassell, Curtis P., Williams, John L., Caetano, Alexandre R., Diallo, Boubacar, Green, Ronnie D., Hailemariam, Lemecha, Hanotte, Olivier, Martinez, Mario L., Morris, Chris A., Silva, Luiz O. C., Spelman, Richard J., Taylor, Jeremy F., Van Tassell, Curtis P., Mulatu, Woudyalew, Zhao, Keyan, Abbey, Colette A., Agaba, Morris, Araujo, Flábio R., Bunch, Rowan J., Burton, James, Gill, Clare A, Gorni, Chiara, Green, Ronnie D., Olivier, Hanotte, Harrison, Blair E., Lien, Sigbjørn, Luff, Bill, Machado, Marco A., Mariani, Paola, McEwan, John C., Morris, Chris A., Mwakaya, Joel, Plastow, Graham, Sim, Warren, Skow, Loren C., Smith, Timothy, Sonstegard, Tad S., Spelman, Richard J., Taylor, Jeremy F., Thomas, Merle B., Valentini, Alessio, Van Tassell, Curtis P., Williams, Paul, Womack, James, Woolliams, John A., Liu, Yue, Qin, Xiang, Worley, Kim C., Gao, Chuan, Gill, Clare A., Jiang, Huaiyang, Liu, Yue, Moore, Stephen S., Nazareth, Lynne V., Ren, Yanru, Song, Xing-Zhi, Wheeler, David A., Worley, Kim C., Bustamante, Carlos D., Hernandez, Ryan D., Muzny, Donna M., Nazareth, Lynne V., Patil, Shobha, Ren, Yanru, San Lucas, Anthony, Wheeler, David A., Fu, Qing, Kent, Matthew P., Lien, Sigbjørn, Moore, Stephen S., Nazareth, Lynne V., Vega, Richard, Wheeler, David A., Abbey, Colette A., Gao, Chuan, Gill, Clare A., Green, Ronnie D., Matukumalli, Lakshmi K., Matukumalli, Aruna, McWilliam, Sean, Van Tassell, Curtis P., Abbey, Colette A., Gill, Clare A., Kent, Matthew P., Lien, Sigbjørn, Matukumalli, Lakshmi K., Schnabel, Robert D., Sclep, Gert, Taylor, Jeremy F., Ajmone-Marsan, Paolo, Bryc, Katarzyna, Bustamante, Carlos D., Choi, Jungwoo, Gao, Hong, Grefenstette, John J., Matukumalli, Lakshmi K., Murdoch, Brenda, Moore, Stephen S., Nazareth, Lynne V., Stella, Alessandra, Van Tassell, Curtis P., Villa-Angulo, Rafael, Wheeler, David A., Wright, Mark, Aerts, Jan, Jann, Oliver, Matukumalli, Lakshmi K., Negrini, Riccardo, Sonstegard, Tad S., Williams, John L., Ajmone-Marsan, Paolo, Grefenstette, John J., Matukumalli, Lakshmi K., Negrini, Riccardo, Schnabel, Robert D., Taylor, Jeremy F., Villa-Angulo, Rafael, Grefenstette, John J., Matukumalli, Lakshmi K., Van Tassell, Curtis P., Villa-Angulo, Rafael, Goddard, Mike E., Hayes, Ben J., Barendse, William, Bradley, Daniel G., Boettcher, Paul J., Bustamante, Carlos D., Choi, Jungwoo, Barbosa da Silva, Marcos, Gill, Clare A., Lau, Lilian P. L., Liu, George E., Lynn, David J., Panzitta, Francesca, Sclep, Gert, Wright, Mark, Bustamante, Carlos D., Dodds, Ken G., McEwan, John C., Taylor, Jeremy F., and Van Tassell, Curtis P.

Published
2009

13. Finanzas a Corto Plazo : Análisis del presupuesto de flujo de efectivo operativo de la empresa metalurgica de Nicaragua,S.A. para el año 2015

Author

Chavarria Estrada, Yader David and Leiva Vega, Richard Javier

Subjects
657 Contabilidad
Abstract

El presente trabajo de seminario de graduación titulado “Planificación Financiera” se desarrolló con el fin de proporcionar un entendimiento más claro sobre la elaboración de un presupuesto de efectivo y estados financieros proforma en la empresa Metalúrgica de Nicaragua S,A. El objetivo general planteado es realizar un presupuesto de efectivo y los estados financieros proforma del periodo 2015. Para dar cumplimiento al primer objetivo se expusieron los fundamentos de las finanzas, tales como el marco teórico, historia y evolución de las finanzas. Enmarcando su importancia en la toma de decisiones e interacción ante los fenómenos económicos externos. El segundo objetivo trata de los elementos de la planificación financiera tales como el estado de situación financiera, Estado de resultado integral, estado de flujo de efectivo y notas a los estados financieros además de información adicional proporcionada por el departamento de ventas y cobranzas de la empresa Metalúrgica de Nicaragua S,A. El tercer objetivo es evaluar las cifras obtenidas mediante la elaboración de un pronóstico de ingresos y gastos para conocer las necesidades de adquisición, los costos y la utilidad que se pueden obtener a través de los servicios; y con ello realizar una planificación del efectivo que permita el desarrollo de un Presupuesto de Caja, para lo cual se debe elaborar un programa de entradas de efectivo con el objeto de conocer los ingresos que obtendrá la empresa y un programa de salidas de efectivo para conocer los gastos que tendrá que efectuar en un período especifico, con los resultados obtenidos la empresa necesita de financiamiento externo requerido para poder apoyar el crecimiento de sus activos proyectados. El cuarto objetivo es el desarrollo del caso práctico de la empresa Metalúrgica de Nicaragua partiendo de los estados financieros 2013 y 2014 tomando en cuenta el comportamiento histórico de las operaciones de la empresa.

Published
2015

14. Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Author

Meredith, Erik L., Ardayfio, Ophelia, Beattie, Kimberly, Dobler, Markus R., Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, HansJoerg, McKinsey, Timothy A., Miranda, Karl, Pagratis, Nikos, Pancost, Margaret, Patnaik, Anup, Phan, Dillon, Plato, Craig, Qian, Ming, Rajaraman, Vasumathy, Rao, Chang, Rozhitskaya, Olga, Ruppen, Thomas, Shi, Jie, Siska, Sarah J., Springer, Clayton, van Eis, Maurice, Vega, Richard B., von Matt, Anette, Yang, Lihua, Yoon, Taeyoung, Zhang, Ji-Hu, Zhu, Na, and Monovich, Lauren G.

Abstract

A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy. As PKC was previously identified as the immediate upstream activator of PKD, PKD vs PKC selectivity was essential to understand the effect of PKD inhibition in models of cardiac hypertrophy and heart failure. The present study describes the modification of the HTS hit to a series of prototype pan-PKD inhibitors with routine 1000-fold PKD vs PKC selectivity. Example compounds inhibited PKD activity in vitro, in cells, and in vivo following oral administration. Their effects on heart morphology and function are discussed herein.

Published
2024
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15. Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Author

Meredith, Erik L., Beattie, Kimberly, Burgis, Robin, Capparelli, Michael, Chapo, Joseph, DiPietro, Lucian, Gamber, Gabriel, Enyedy, Istvan, Hood, David B., Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith A., Lee, Wendy, Lemon, Douglas D., McKinsey, Timothy A., Miranda, Karl, Pagratis, Nikos, Phan, Dillon, Plato, Craig, Rao, Chang, Rozhitskaya, Olga, Soldermann, Nicolas, Springer, Clayton, van Eis, Maurice, Vega, Richard B., Yan, Wanlin, Zhu, Qingming, and Monovich, Lauren G.

Abstract

The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphology is reported herein.

Published
2024
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16. 3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Author

Gamber, Gabriel G., Meredith, Erik, Zhu, Qingming, Yan, Wanlin, Rao, Chang, Capparelli, Michael, Burgis, Robin, Enyedy, Istvan, Zhang, Ji-Hu, Soldermann, Nicolas, Beattie, Kimberley, Rozhitskaya, Olga, Koch, Keith A., Pagratis, Nikos, Hosagrahara, Vinayak, Vega, Richard B., McKinsey, Timothy A., and Monovich, Lauren

Published
2011
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20. Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Author

Meredith, Erik L., primary, Beattie, Kimberly, additional, Burgis, Robin, additional, Capparelli, Michael, additional, Chapo, Joseph, additional, DiPietro, Lucian, additional, Gamber, Gabriel, additional, Enyedy, Istvan, additional, Hood, David B., additional, Hosagrahara, Vinayak, additional, Jewell, Charles, additional, Koch, Keith A., additional, Lee, Wendy, additional, Lemon, Douglas D., additional, McKinsey, Timothy A., additional, Miranda, Karl, additional, Pagratis, Nikos, additional, Phan, Dillon, additional, Plato, Craig, additional, Rao, Chang, additional, Rozhitskaya, Olga, additional, Soldermann, Nicolas, additional, Springer, Clayton, additional, van Eis, Maurice, additional, Vega, Richard B., additional, Yan, Wanlin, additional, Zhu, Qingming, additional, and Monovich, Lauren G., additional

Published
2010
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21. Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Author

Meredith, Erik L., primary, Ardayfio, Ophelia, additional, Beattie, Kimberly, additional, Dobler, Markus R., additional, Enyedy, Istvan, additional, Gaul, Christoph, additional, Hosagrahara, Vinayak, additional, Jewell, Charles, additional, Koch, Keith, additional, Lee, Wendy, additional, Lehmann, HansJoerg, additional, McKinsey, Timothy A., additional, Miranda, Karl, additional, Pagratis, Nikos, additional, Pancost, Margaret, additional, Patnaik, Anup, additional, Phan, Dillon, additional, Plato, Craig, additional, Qian, Ming, additional, Rajaraman, Vasumathy, additional, Rao, Chang, additional, Rozhitskaya, Olga, additional, Ruppen, Thomas, additional, Shi, Jie, additional, Siska, Sarah J., additional, Springer, Clayton, additional, van Eis, Maurice, additional, Vega, Richard B., additional, von Matt, Anette, additional, Yang, Lihua, additional, Yoon, Taeyoung, additional, Zhang, Ji-Hu, additional, Zhu, Na, additional, and Monovich, Lauren G., additional

Published
2010
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22. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

Author

Monovich, Lauren, primary, Vega, Richard B., additional, Meredith, Erik, additional, Miranda, Karl, additional, Rao, Chang, additional, Capparelli, Michael, additional, Lemon, Douglas D., additional, Phan, Dillon, additional, Koch, Keith A., additional, Chapo, Joseph A., additional, Hood, David B., additional, and McKinsey, Timothy A., additional

Published
2009
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23. Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1

Author

Monovich, Lauren, primary, Koch, Keith A., additional, Burgis, Robin, additional, Osimboni, Ekundayo, additional, Mann, Thierry, additional, Wall, Daniel, additional, Gao, Jinhai, additional, Feng, Yan, additional, Vega, Richard B., additional, Turner, Benjamin A., additional, Hood, David B., additional, Law, Andy, additional, Papst, Philip J., additional, Koditek, David, additional, Chapo, Joseph A., additional, Reid, Brian G., additional, Melvin, Lawrence S., additional, Pagratis, Nikos C., additional, and McKinsey, Timothy A., additional

Published
2009
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24. Positive Selection of a Pre-Expansion CAG Repeat of the Human SCA2 Gene

Author

Yu, Fuli, primary, Sabeti, Pardis C, additional, Hardenbol, Paul, additional, Fu, Qing, additional, Fry, Ben, additional, Lu, Xiuhua, additional, Ghose, Sy, additional, Vega, Richard, additional, Perez, Ag, additional, Pasternak, Shiran, additional, Leal, Suzanne M, additional, Willis, Thomas D, additional, Nelson, David L, additional, Belmont, John, additional, and Gibbs, Richard A, additional

Published
2005
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25. Healthy habit

Author

Vega, Richard

Abstract

I'm 47 years old and have been lifting weights since 1976. I began training to be a better football player in high school and established a habit of working out [...]

Published
2009

26. Positive Selection of a Pre-Expansion CAG Repeat of the Human SCA2 Gene.

Author

Fuli Yu, Sabeti, Pardis C., Hardenbol, Paul, Qing Fu, Fry, Ben, Xiuhua Lu, Ghose, Sy, Vega, Richard, Perez, Ag, Pasternak, Shiran, Leal, Suzanne M., Willis, Thomas D., Nelson, David L., Belmont, John, Gibbs, Richard A., and Abecasis, Goncalo

Subjects
HUMAN chromosomes, HUMAN genetics, NATURAL selection, GENETICS, GENEALOGY
Abstract

A region of approximately one megabase of human Chromosome 12 shows extensive linkage disequilibrium in Utah residents with ancestry from northern and western Europe. This strikingly large linkage disequilibrium block was analyzed with statistical and experimental methods to determine whether natural selection could be implicated in shaping the current genome structure. Extended Haplotype Homozygosity and Relative Extended Haplotype Homozygosity analyses on this region mapped a core region of the strongest conserved haplotype to the exon 1 of the Spinocerebellar ataxia type 2 gene (SCA2). Direct DNA sequencing of this region of the SCA2 gene revealed a significant association between a pre-expanded allele [(CAG)8CAA(CAG)4CAA(CAG)8] of CAG repeats within exon 1 and the selected haplotype of the SCA2 gene. A significantly negative Tajima's D value (−2.20, p < 0.01) on this site consistently suggested selection on the CAG repeat. This region was also investigated in the three other populations, none of which showed signs of selection. These results suggest that a recent positive selection of the pre-expansion SCA2 CAG repeat has occurred in Utah residents with European ancestry. [ABSTRACT FROM AUTHOR]

Published
2005
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27. READERS' OPINIONS.

Author

Vega, Richard, Moravec, Pavel, DeCelles, Charles, and James, William

Subjects
*LETTERS to the editor, *SPIRITUAL life, *CHURCH work, *PRAYER, *PRIESTS
Abstract

Several letters to the editor are presented in response to articles in previous issues including "Priestly Spirituality," by Dmitry Gallaro in the December 2008 issue, "A Great Priest and a Great Jesuit," by Father Benedict Groeschel in the March 2009 issue, and "Pastoral Ministry Is Fruitless Without Prayer," by Father Myers in the March 2009 issue.

Published
2009

29. FEEDBACK.

Author

Vega, Richard, Funderburk, Cantrell, Shiva, McGrady, Ryan, Silanskis, Phillip, Shelby, Donald T., Frye, Craig, and Polidoro, Anthony

Subjects
LETTERS to the editor, PHYSICAL fitness, BODYBUILDING, WEIGHT training, NUTRITION
Abstract

Several letters to the editor are presented in response to articles in previous issues including a letter on how the periodical helps in bodybuilding, a letter on how the periodical helps in expanding the knowledge of fitness and nutrition, and an article on workout plans in a previous issue.

Published
2009

30. BELEAGUERED PRIESTS.

Author

Vega, Richard

Subjects
*LETTERS to the editor, *PRIESTS
Abstract

A letter to the editor is presented in response to the article "The Other Health Crisis," by Paul Stanosz in the November 23, 2007 issue.

Published
2008

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