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1. Bronchoscopic Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage-induced Acute Respiratory Failure in MPO-ANCA Vasculitis: A Case Report

Author

Smesseim Illaa, Schaepman-Ruys Titia, Duitman Jan Willem, Vegting Yosta, Raasveld Jorinde, Hilhorst Marc, Vlaar Alexander, van Es Josien, and Bonta Peter

Subjects
ards, diffuse alveolar hemorrhage, dah, novoseven, vasculitis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Diffuse alveolar haemorrhage (DAH) is a potentially life-threatening disease, characterized by diffuse accumulation of red blood cells within the alveoli. It can be caused by a variety of disorders. In case DAH results in severe respiratory failure, veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be required. Since VV-ECMO coincides with the need for anticoagulation therapy, this results in a major clinical challenge in DAH patients with hemoptysis.

Published
2022
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3. Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy

Author

Stalman, Eileen W., Wieske, Luuk, Keijser, Jim B.D., van Dam, Koos P.J., Kummer, Laura Y.L., Wilbrink, Maarten F., van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D’Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederique J., Voskuyl, Alexandre E., Broens, Bo, Parra Sanchez, Agner, van Els, Cécile A.C. M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Onno Teng, Y.K., van Paassen, Pieter, Busch, Matthias H., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirkjan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Cristianawati, Olvi, Brinke, Anja ten, Verstegen, Niels J.M., Zwinderman, Koos A.H., van Ham, S. Marieke, Rispens, Theo, Welkers, Matthijs R., Jonges, Marcel, Eftimov, Filip, and Kuijpers, Taco W.

Published
2024
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4. mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses

Author

van Allaart, Renée CF., Baars, Adája E., Bekkenk, Marcel W., Bemelman, Frederike J., Boekel, Laura, Bos, Amélie V., Bosma, Angela L., Broens, Bo, Brusse, Esther, Busch, Matthias H., Cristianawati, Olvi, van Doorn, Pieter A., Elias, George, van Els, Cécile ACM., van Gils, Marit J., Goedee, H Stephan, Hijnen, Dirk Jan, Hilhorst, Marc L., Horváth, Barbara, Jallah, Papay BP., de Jongh, Rivka, Mirfazeli, Elham S., Musters, Annelie H., Keijser, Jim BD., van Kempen, Zoé LE., Killestein, Joep, Kreher, Christine, de Leeuw, Karina, van der Kooi, Anneke J., van Ouwerkerk, Lotte, van Paassen, Pieter, Cabeza, Virginia Palomares, Parra Sanchez, Agner R., Ludo van der Pol, W., Post, Nicoline F., Raaphorst, Joop, Ruiter, Annabel M., Rutgers, Abraham, Schreurs, Corine RG., Spuls, Phyllis I., Takkenberg, R Bart, Tas, Sander W., Teng, YK Onno, Vegting, Yosta, Verschuuren, Jan JGM., Voskuyl, Alexandre E., de Wit, Jelle, Wolbink, Gerrit J., van der Woude, Diane, Zwinderman, Koos AH., van den Dijssel, Jet, Duurland, Mariël C., Konijn, Veronique AL., Kummer, Laura YL., Hagen, Ruth R., Kuijper, Lisan H., Wieske, Luuk, van Dam, Koos PJ., Stalman, Eileen W., Steenhuis, Maurice, Geerdes, Dionne M., Mok, Juk Yee, Kragten, Angela HM., Menage, Charlotte, Koets, Lianne, Veldhuisen, Barbera, Verstegen, Niels JM., van der Schoot, C Ellen, van Esch, Wim JE., D'Haens, Geert RAM., Löwenberg, Mark, Volkers, Adriaan G., Rispens, Theo, Kuijpers, Taco W., Eftimov, Filip, van Gisbergen, Klaas PJM., van Ham, S Marieke, ten Brinke, Anja, and van de Sandt, Carolien E.

Published
2024
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5. Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

Author

van Dam, Koos P. J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y. L., van Kempen, Zoé L. E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R. A. M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A. C. M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C. F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B. P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B. D., Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J. M., van Ham, S. Marieke, Rispens, Theo, Kuijpers, Taco W., Löwenberg, Mark, and Eftimov, Filip

Published
2023
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7. Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

Author

van Dam, Koos P.J., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y.L., Roosen, Jesse, van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D'Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Teng, Y.K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B.P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R.G., van der Pol, W.Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B.D., Cristianawati, Olvi, Rispens, Theo, Brinke, Anja ten, Verstegen, Niels J.M., Marieke van Ham, S., Tas, Sander W., Kuijpers, Taco W., and Eftimov, Filip

Published
2023
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9. Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Author

de Jongh, Rivka, van de Sandt, Carolien, Kuijper, Lisan, Duurland, Mariel, Hagen, Ruth, van den Dijssel, Jet, Kreher, Christine, Bos, Amelie, Palomares Cabeza, Viriginia, Konijn, Veronique, Elias, George, Vallejo, Juan, van Gils, Marrit, Ashhurst, Tom, Nejentsev, Sergey, Mirfazeli, Elham, Boekel, Laura, Stalman, Eileen W, Wieske, Luuk, Hooijberg, Femke, van Dam, Koos P J, Besten, Yaëlle R, Kummer, Laura Y L, Steenhuis, Maurice, van Kempen, Zoé L E, Killestein, Joep, Volkers, Adriaan G, Tas, Sander W, van der Kooi, Anneke J, Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R Bart, D'Haens, Geert R A M, Spuls, Phyllis I, Bekkenk, Marcel W, Musters, Annelie H, Post, Nicoline F, Bosma, Angela L, Hilhorst, Marc L, Vegting, Yosta, Bemelman, Frederike J, Voskuyl, Alexandre E, Broens, Bo, Parra Sanchez, Agner, van Els, Cécile A C M, de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J G M, Ruiter, Annabel M, van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Cornelia F, Teng, Y K Onno, van Paassen, Pieter, Busch, Matthias H, Jallah, Papay B P, Brusse, Esther, van Doorn, Pieter A, Baars, Adája E, Hijnen, Dirk Jan, Schreurs, Corine R G, van der Pol, W Ludo, Goedee, H Stephan, Vogelzang, Erik H, Leeuw, Maureen, Atiqi, Sadaf, van Vollenhoven, Ronald, Gerritsen, Martijn, van der Horst-Bruinsma, Irene E, Lems, Willem F, Nurmohamed, Mike T, Boers, Maarten, Keijzer, Sofie, Keijser, Jim, Boogaard, Arend, Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J M, Zwinderman, Koos A H, van Ham, S Marieke, Rispens, Theo, Kuijpers, Taco W, Wolbink, Gertjan, and Eftimov, Filip

Published
2022
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10. Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

Author

de Jongh, R., van de Sandt, C.E., Kuijper, L., Duurland, M., Hagen, R.R., van den Dijssel, J., Kreher, C., Bos, A., Palomares Cabeza, V., Konijn, V.A.L., Elias, G., Vallejo, J.G., van Gils, M.J., Ashhurst, T.M., Nejentsev, S., Mirfazeli, E.S., Wieske, Luuk, van Dam, Koos P J, Steenhuis, Maurice, Stalman, Eileen W, Kummer, Laura Y L, van Kempen, Zoé L E, Killestein, Joep, Volkers, Adriaan G, Tas, Sander W, Boekel, Laura, Wolbink, Gerrit J, van der Kooi, Anneke J, Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R Bart, D'Haens, Geert R A M, Spuls, Phyllis I, Bekkenk, Marcel W, Musters, Annelie H, Post, Nicoline F, Bosma, Angela L, Hilhorst, Marc L, Vegting, Yosta, Bemelman, Frederike J, Voskuyl, Alexandre E, Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A C M, de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J G M, Ruiter, Annabel M, van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C F, Teng, Y K Onno, van Paassen, Pieter, Busch, Matthias H, Jallah, Papay B P, Brusse, Esther, van Doorn, Pieter A, Baars, Adája E, Hijnen, Dirk Jan, Schreurs, Corine R G, van der Pol, W Ludo, Goedee, H Stephan, Keijzer, Sofie, Keijser, Jim B D, Boogaard, Arend, Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J M, Zwinderman, Koos A H, van Ham, S Marieke, Kuijpers, Taco W, Rispens, Theo, and Eftimov, Filip

Published
2022
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11. Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Author

Wieske, Luuk, Kummer, Laura Y. L., van Dam, Koos P. J., Stalman, Eileen W., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, Volkers, Adriaan G., D’Haens, Geert R. A. M., Tas, Sander W., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Killestein, Joep, van Kempen, Zoé L. E., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, Wolbink, Gertjan, Boekel, Laura, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Cornelia F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, B. Papay, Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirkjan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Rispens, Theo, ten Brinke, Anja, Verstegen, Niels J. M., Zwinderman, Koos A. H., van Ham, S. Marieke, Kuijpers, Taco W., and Eftimov, Filip

Published
2022
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14. Infiltrative classical monocyte-derived andSPP1lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis

Author

Vegting, Yosta, primary, Jongejan, Aldo, additional, Neele, Annette E, additional, Claessen, Nike, additional, Sela, Gal, additional, Prange, Koen H M, additional, Kers, Jesper, additional, Roelofs, Joris J T H, additional, van der Heijden, Joost W, additional, de Boer, Onno J, additional, Remmerswaal, Ester B M, additional, Vogt, Liffert, additional, Bemelman, Frederike J, additional, de Winther, Menno P J, additional, Moerland, Perry D, additional, and Hilhorst, Marc L, additional

Published
2024
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15. Clinical and humoral response after SARS-CoV-2 breakthrough infection in patients receiving immunosuppressant therapy

Author

T2B! immunity against SARS-CoV-2 study group, Stalman, Eileen W., Wieske, Luuk, Keijser, Jim B.D., van Dam, Koos P.J., Kummer, Laura Y.L., Wilbrink, Maarten F., van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D'Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederique J., Voskuyl, Alexandre E., Broens, Bo, Parra Sanchez, Agner, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Onno Teng, Y. K., van Paassen, Pieter, Busch, Matthias H., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirkjan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, T2B! immunity against SARS-CoV-2 study group, Stalman, Eileen W., Wieske, Luuk, Keijser, Jim B.D., van Dam, Koos P.J., Kummer, Laura Y.L., Wilbrink, Maarten F., van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D'Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederique J., Voskuyl, Alexandre E., Broens, Bo, Parra Sanchez, Agner, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Onno Teng, Y. K., van Paassen, Pieter, Busch, Matthias H., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirkjan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, and Keijzer, Sofie

Abstract

Background: Despite impaired humoral response in patients treated with immunosuppressants (ISPs), recent studies found similar severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection compared to controls. One potential explanation is the rapid generation of humoral response on infection, but evidence is lacking. Objectives: We investigated the longitudinal dynamics of the SARS-CoV-2 antibody repertoire after SARS-CoV-2 delta and omicron breakthrough infection in patients with immune-mediated inflammatory diseases (IMIDs) receiving ISP therapy and controls. Methods: As a prospective substudy of the national Target-to-B! (T2B!) consortium, we included IMID patients receiving ISPs therapy and controls who reported SARS-CoV-2 breakthrough infection between July 1, 2021, and April 1, 2022. To get an impression of the dynamics of the antibody repertoire, 3 antibody titers of wild-type RBD, wild-type S, and omicron RBD were measured at 4 time points after SARS-CoV-2 breakthrough infection. Results: We included 302 IMID patients receiving ISPs and 178 controls. Antibody titers increased up to 28 days after breakthrough infection in both groups. However, in IMID patients receiving therapy with anti-CD20 and sphingosine-1 phosphate receptor modulators, antibody titers were considerably lower compared to controls. In the anti-TNF group, we observed slightly lower antibody titers in the early stages and a faster decline of antibodies after infection compared to controls. Breakthrough infections were mostly mild, and hospitalization was required in less than 1% of cases. Conclusions: Most ISPs do not influence the dynamics of the SARS-CoV-2 antibody repertoire and exhibit a rapid recall response with cross-reactive antibody clones toward new virus variants. However, in patients treated with anti-CD20 therapy or sphingosine-1 phosphate receptor modulators, the dynamics were greatly impaired, and to a lesser extent in those who received a

Published
2024

16. Cardiovascular risk in ANCA-associated vasculitis: monocyte phenotyping reveals distinctive signatures between serological subsets

Author

Vegting, Yosta, primary, Hanford, Katie ML, additional, Jongejan, Aldo, additional, Gajadin, Gayle RS, additional, Versloot, Miranda, additional, van der Bom-Baylon, Nelly D, additional, Dekker, Tamara, additional, Penne, E Lars, additional, van der Heijden, Joost W, additional, Houben, Eline, additional, Bemelman, Frederike J, additional, Neele, Annette E, additional, Moerland, Perry D., additional, Vogt, Liffert, additional, Kroon, Jeffrey, additional, and Hilhorst, Marc L, additional

Published
2024
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18. Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations

Author

Neurologen, Brain, van Dam, Koos P.J., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y.L., Roosen, Jesse, van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D'Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Teng, Y. K.Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B.P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B.D., the T2B! Immunity against SARS-CoV-2 study group, Neurologen, Brain, van Dam, Koos P.J., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y.L., Roosen, Jesse, van Kempen, Zoé L.E., Killestein, Joep, Volkers, Adriaan G., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Löwenberg, Mark, Takkenberg, R. Bart, D'Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Teng, Y. K.Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B.P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B.D., and the T2B! Immunity against SARS-CoV-2 study group

Published
2023

19. Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases:long-term humoral immune responses and effects on disease activity

Author

van Dam, Koos P.J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y.L., van Kempen, Zoé L.E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Teng, Y. K.Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B.P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B.D., Cristianawati, Olvi, Eftimov, Filip, van Dam, Koos P.J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y.L., van Kempen, Zoé L.E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R.A.M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A.C.M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J.G.M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C.F., Teng, Y. K.Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B.P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R.G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B.D., Cristianawati, Olvi, and Eftimov, Filip

Abstract

Background: Patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressants (ISPs) may have impaired long-term humoral immune responses and increased disease activity after SARS-CoV-2 infection. We aimed to investigate long-term humoral immune responses against SARS-CoV-2 and increased disease activity after a primary SARS-CoV-2 infection in unvaccinated IMID patients on ISPs. Methods: IMID patients on active treatment with ISPs and controls (i.e. IMID patients not on ISP and healthy controls) with a confirmed SARS-CoV-2 infection before first vaccination were included from an ongoing prospective cohort study (T2B! study). Clinical data on infections and increased disease activity were registered using electronic surveys and health records. A serum sample was collected before first vaccination to measure SARS-CoV-2 anti-receptor-binding domain (RBD) antibodies. Results: In total, 193 IMID patients on ISP and 113 controls were included. Serum samples from 185 participants were available, with a median time of 173 days between infection and sample collection. The rate of seropositive IMID patients on ISPs was 78% compared to 100% in controls (p < 0.001). Seropositivity rates were lowest in patients on anti-CD20 (40.0%) and anti-tumor necrosis factor (TNF) agents (60.5%), as compared to other ISPs (p < 0.001 and p < 0.001, respectively). Increased disease activity after infection was reported by 68 of 260 patients (26.2%; 95% CI 21.2–31.8%), leading to ISP intensification in 6 out of these 68 patients (8.8%). Conclusion: IMID patients using ISPs showed reduced long-term humoral immune responses after primary SARS-CoV-2 infection, which was mainly attributed to treatment with anti-CD20 and anti-TNF agents. Increased disease activity after SARS-CoV-2 infection was reported commonly, but was mostly mild. Trial registration: NL74974.018.20, Trial ID: NL8900. Register

Published
2023

20. Additional file 1 of Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

Author

van Dam, Koos P. J., Volkers, Adriaan G., Wieske, Luuk, Stalman, Eileen W., Kummer, Laura Y. L., van Kempen, Zoé L. E., Killestein, Joep, Tas, Sander W., Boekel, Laura, Wolbink, Gerrit J., van der Kooi, Anneke J., Raaphorst, Joost, Takkenberg, R. Bart, D’Haens, Geert R. A. M., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, van Els, Cécile A. C. M., de Wit, Jelle, Rutgers, Abraham, de Leeuw, Karina, Horváth, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Renée C. F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, Papay B. P., Brusse, Esther, van Doorn, Pieter A., Baars, Adája E., Hijnen, Dirk Jan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Keijzer, Sofie, Keijser, Jim B. D., Cristianawati, Olvi, ten Brinke, Anja, Verstegen, Niels J. M., van Ham, S. Marieke, Rispens, Theo, Kuijpers, Taco W., Löwenberg, Mark, and Eftimov, Filip

Abstract

Additional file 1.

Published
2023
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21. Persistence of seroconversion at 6 months following primary immunisation in patients with immune-mediated inflammatory diseases

Author

Wieske, Luuk, primary, Stalman, Eileen W, additional, van Dam, P J Koos, additional, Kummer, Laura Y, additional, Steenhuis, Maurice, additional, van Kempen, Zoe L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, Van der Kooi, Anneke, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, Bart, additional, D’Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederique J, additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, Wit, Jelle De, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F, additional, Teng, Y K Onno, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája Elisabeth, additional, Hijnen, Dirkjan, additional, Schreurs, Corine R G, additional, Van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, van Ham, S Marieke, additional, Kuijpers, Taco W, additional, Rispens, Theo, additional, and Eftimov, Filip, additional

Published
2023
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22. Primary SARS-CoV-2 infection in patients with immune-mediated inflammatory diseases: long-term humoral immune responses and effects on disease activity

Author

Dam, Koos van, primary, Volkers, Adriaan, additional, Wieske, Luuk, additional, Stalman, Eileen, additional, Kummer, Laura, additional, kempen, Zoe van, additional, Killestein, Joep, additional, Tas, Sander, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, Kooi, Anneke van der, additional, Raaphorst, Joost, additional, Takkenberg, Bart, additional, D'Haens, Geert, additional, Spuls, Phyllis, additional, Bekkenk, Marcel, additional, Musters, Annelie, additional, Post, Nicoline, additional, Bosma, Angela, additional, Hilhorst, Marc, additional, Vegting, Yosta, additional, Bemelman, Frederike, additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, Els, Cecile van, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horvath, Barbara, additional, Verschuuren, Jan, additional, Ruiter, Annabel, additional, Ouwerkerk, Lotte van, additional, Woude, Diane van der, additional, Allaart, Renee, additional, Teng, Onno, additional, Paassen, Pieter van, additional, Busch, Matthias, additional, Jallah, Papay, additional, Brusse, Esther, additional, Doorn, Pieter van, additional, Baars, Adaja, additional, Hijnen, DirkJan, additional, Schreurs, Corine, additional, Pol, Ludo van der, additional, Goedee, Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, Cristianawati, Olvi, additional, Brinke, Anja ten, additional, Verstegen, Niels, additional, Ham, Marieke van, additional, Rispens, Theo, additional, Kuijpers, Taco, additional, Lowenberg, Mark, additional, and Eftimov, Filip, additional

Published
2023
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23. Longitudinal Dynamics of the SARS-CoV-2 Antibody Repertoire after SARS-CoV-2 Delta and Omicron Breakthrough Infections in Patients with Immune-Mediated Inflammatory Diseases

Author

Stalman, Eileen, primary, Wieske, Luuk, additional, Keijser, Jim, additional, van Dam, Koos, additional, Kummer, Laura, additional, Wilbrink, Maarten F., additional, van Kempen, Zoé, additional, Killestein, Joep, additional, Volkers, Adriaan G., additional, Tas, Sander, additional, Boekel, Laura, additional, Wolbink, Gertjan, additional, van der Kooi, Anneke J., additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R. Bart, additional, D&apos;Haens, Geert R.A.M., additional, Spuls, Phyllis I., additional, Bekkenk, Marcel W., additional, Musters, Annelie H., additional, Post, Nicoline F., additional, Bosma, Angela L., additional, Hilhorst, Marc L., additional, Vegting, Yosta, additional, Bemelman, Frederike J., additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, van Els, Cecile, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J.G.M., additional, Ruiter, Annabel M., additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F., additional, Teng, Onno YK, additional, van Paassen, Pieter, additional, Busch, Matthias, additional, Brusse, Esther, additional, van Doorn, Pieter, additional, Baars, Adája E., additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R.G., additional, van der Pol, Ludo, additional, Goedee, H. Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels, additional, Zwinderman, Aeilko H., additional, van Ham, Marieke, additional, Rispens, Theo, additional, Welkers, Matthijs R.A., additional, Jonges, Marcel, additional, Eftimov, Filip, additional, and Kuijpers, Taco, additional

Published
2023
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25. Breakthrough infections with the SARS-CoV-2 omicron (B.1.1.529) variant in patients with immune-mediated inflammatory diseases

Author

Stalman, Eileen W, primary, Wieske, Luuk, additional, van Dam, Koos P J, additional, Kummer, Laura Y, additional, van Kempen, Zoé L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, Boekel, Laura, additional, Wolbink, Gertjan J, additional, Van der Kooi, Anneke J, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R Bart, additional, D’Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederique J, additional, Voskuyl, Alexandre E, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, Wit, Jelle De, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, C F, additional, Teng, Onno Y K, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája Elisabeth, additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R G, additional, Van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Steenhuis, Maurice, additional, Keijzer, Sofie, additional, Keijser, Jim B D, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, Rispens, Theo, additional, van Ham, S Marieke, additional, Kuijpers, Taco W, additional, and Eftimov, Filip, additional

Published
2022
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27. Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Author

Boekel, Laura, primary, Stalman, Eileen W, additional, Wieske, Luuk, additional, Hooijberg, Femke, additional, van Dam, Koos P J, additional, Besten, Yaëlle R, additional, Kummer, Laura Y L, additional, Steenhuis, Maurice, additional, van Kempen, Zoé L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, van der Kooi, Anneke J, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R Bart, additional, D'Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederike J, additional, Voskuyl, Alexandre E, additional, Broens, Bo, additional, Parra Sanchez, Agner, additional, van Els, Cécile A C M, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F, additional, Teng, Y K Onno, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája E, additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R G, additional, van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Vogelzang, Erik H, additional, Leeuw, Maureen, additional, Atiqi, Sadaf, additional, van Vollenhoven, Ronald, additional, Gerritsen, Martijn, additional, van der Horst-Bruinsma, Irene E, additional, Lems, Willem F, additional, Nurmohamed, Mike T, additional, Boers, Maarten, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, van de Sandt, Carolien, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, van Ham, S Marieke, additional, Rispens, Theo, additional, Kuijpers, Taco W, additional, Wolbink, Gertjan, additional, Eftimov, Filip, additional, de Jongh, Rivka, additional, Kuijper, Lisan, additional, Duurland, Mariel, additional, Hagen, Ruth, additional, van den Dijssel, Jet, additional, Kreher, Christine, additional, Bos, Amelie, additional, Palomares Cabeza, Viriginia, additional, Konijn, Veronique, additional, Elias, George, additional, Vallejo, Juan, additional, van Gils, Marrit, additional, Ashhurst, Tom, additional, Nejentsev, Sergey, additional, and Mirfazeli, Elham, additional

Published
2022
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29. Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

Author

Wieske, Luuk, primary, van Dam, Koos P J, additional, Steenhuis, Maurice, additional, Stalman, Eileen W, additional, Kummer, Laura Y L, additional, van Kempen, Zoé L E, additional, Killestein, Joep, additional, Volkers, Adriaan G, additional, Tas, Sander W, additional, Boekel, Laura, additional, Wolbink, Gerrit J, additional, van der Kooi, Anneke J, additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R Bart, additional, D'Haens, Geert R A M, additional, Spuls, Phyllis I, additional, Bekkenk, Marcel W, additional, Musters, Annelie H, additional, Post, Nicoline F, additional, Bosma, Angela L, additional, Hilhorst, Marc L, additional, Vegting, Yosta, additional, Bemelman, Frederike J, additional, Voskuyl, Alexandre E, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, van Els, Cécile A C M, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J G M, additional, Ruiter, Annabel M, additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Renée C F, additional, Teng, Y K Onno, additional, van Paassen, Pieter, additional, Busch, Matthias H, additional, Jallah, Papay B P, additional, Brusse, Esther, additional, van Doorn, Pieter A, additional, Baars, Adája E, additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R G, additional, van der Pol, W Ludo, additional, Goedee, H Stephan, additional, Keijzer, Sofie, additional, Keijser, Jim B D, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels J M, additional, Zwinderman, Koos A H, additional, van Ham, S Marieke, additional, Kuijpers, Taco W, additional, Rispens, Theo, additional, Eftimov, Filip, additional, de Jongh, R., additional, van de Sandt, C.E., additional, Kuijper, L., additional, Duurland, M., additional, Hagen, R.R., additional, van den Dijssel, J., additional, Kreher, C., additional, Bos, A., additional, Palomares Cabeza, V., additional, Konijn, V.A.L., additional, Elias, G., additional, Vallejo, J.G., additional, van Gils, M.J., additional, Ashhurst, T.M., additional, Nejentsev, S., additional, and Mirfazeli, E.S., additional

Published
2022
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30. Additional file 2 of Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Author

Wieske, Luuk, Kummer, Laura Y. L., van Dam, Koos P. J., Stalman, Eileen W., van der Kooi, Anneke J., Raaphorst, Joost, L��wenberg, Mark, Takkenberg, R. Bart, Volkers, Adriaan G., D���Haens, Geert R. A. M., Tas, Sander W., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Killestein, Joep, van Kempen, Zo�� L. E., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, Wolbink, Gertjan, Boekel, Laura, Rutgers, Abraham, de Leeuw, Karina, Horv��th, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Cornelia F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, B. Papay, Brusse, Esther, van Doorn, Pieter A., Baars, Ad��ja E., Hijnen, Dirkjan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Rispens, Theo, ten Brinke, Anja, Verstegen, Niels J. M., Zwinderman, Koos A. H., van Ham, S. Marieke, Kuijpers, Taco W., and Eftimov, Filip

Subjects
body regions, viruses, fungi, skin and connective tissue diseases, respiratory tract diseases
Abstract

Additional file 2: Table S1. Demographics. Figure S1. Study flowchart. Figure S2. Adverse events in patients with IMIDs after SARS-CoV-2 vaccination. Figure S3. Adverse events after SARS-CoV-2 vaccination per IMID.

Published
2022
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31. Additional file 1 of Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Author

Wieske, Luuk, Kummer, Laura Y. L., van Dam, Koos P. J., Stalman, Eileen W., van der Kooi, Anneke J., Raaphorst, Joost, L��wenberg, Mark, Takkenberg, R. Bart, Volkers, Adriaan G., D���Haens, Geert R. A. M., Tas, Sander W., Spuls, Phyllis I., Bekkenk, Marcel W., Musters, Annelie H., Post, Nicoline F., Bosma, Angela L., Hilhorst, Marc L., Vegting, Yosta, Bemelman, Frederike J., Killestein, Joep, van Kempen, Zo�� L. E., Voskuyl, Alexandre E., Broens, Bo, Sanchez, Agner Parra, Wolbink, Gertjan, Boekel, Laura, Rutgers, Abraham, de Leeuw, Karina, Horv��th, Barbara, Verschuuren, Jan J. G. M., Ruiter, Annabel M., van Ouwerkerk, Lotte, van der Woude, Diane, Allaart, Cornelia F., Teng, Y. K. Onno, van Paassen, Pieter, Busch, Matthias H., Jallah, B. Papay, Brusse, Esther, van Doorn, Pieter A., Baars, Ad��ja E., Hijnen, Dirkjan, Schreurs, Corine R. G., van der Pol, W. Ludo, Goedee, H. Stephan, Steenhuis, Maurice, Rispens, Theo, ten Brinke, Anja, Verstegen, Niels J. M., Zwinderman, Koos A. H., van Ham, S. Marieke, Kuijpers, Taco W., and Eftimov, Filip

Abstract

Additional file 1. Adverse events questionnaire.

Published
2022
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32. SARS-CoV-2 Delta Breakthrough Infections in Vaccinated Patients with Immune-Mediated Inflammatory Diseases Using Immunosuppressants – Data from Two Controlled Prospective Cohort Studies

Author

Boekel, Laura, primary, Stalman, Eileen, additional, Wieske, Luuk, additional, Hooijberg, Femke, additional, van Dam, Koos, additional, Besten, Yaëlle, additional, Kummer, Laura, additional, Steenhuis, Maurice, additional, van Kempen, Zoé, additional, Killestein, Joep, additional, Volkers, Adriaan G., additional, Tas, Sander, additional, van der Kooi, Anneke J., additional, Raaphorst, Joost, additional, Löwenberg, Mark, additional, Takkenberg, R. Bart, additional, D&apos;Haens, Geert R.A.M., additional, Spuls, Phyllis I., additional, Bekkenk, Marcel W., additional, Musters, Annelie H., additional, Post, Nicoline F., additional, Bosma, Angela L., additional, Hilhorst, Marc L., additional, Vegting, Yosta, additional, Bemelman, Frederike J., additional, Voskuyl, Alexandre, additional, Broens, Bo, additional, Sanchez, Agner Parra, additional, van Els, Cecile, additional, de Wit, Jelle, additional, Rutgers, Abraham, additional, de Leeuw, Karina, additional, Horváth, Barbara, additional, Verschuuren, Jan J.G.M., additional, Ruiter, Annabel M., additional, van Ouwerkerk, Lotte, additional, van der Woude, Diane, additional, Allaart, Cornelia F., additional, Teng, Onno YK, additional, van Paassen, Pieter, additional, Busch, Matthias, additional, Jallah, Papay B.P., additional, Brusse, Esther, additional, van Doorn, Pieter, additional, Baars, Adája E., additional, Hijnen, Dirk Jan, additional, Schreurs, Corine R.G., additional, van der Pol, Ludo, additional, Goedee, H. Stephan, additional, Vogelzang, Erik, additional, Leeuw, Maureen, additional, Atiqi, Sadaf, additional, van Vollenhoven, Ronald, additional, Gerritsen, Martijn, additional, van der Horst-Bruinsma, Irene E., additional, Lems, Willem F., additional, Nurmohamed, Michael, additional, Boers, Maarten, additional, Keijzer, Sofie, additional, Keijser, Jim, additional, Boogaard, Arend, additional, Cristianawati, Olvi, additional, ten Brinke, Anja, additional, Verstegen, Niels, additional, Zwinderman, Aeilko H., additional, van Ham, Marieke, additional, Rispens, Theo, additional, Kuijpers, Taco, additional, Wolbink, Gertjan, additional, and Eftimov, Filip, additional

Published
2022
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33. Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Author

Tang, Cheng-Chia, primary, Castro Andrade, Christian D, additional, O'Meara, Maureen J, additional, Yoon, Sung-Hee, additional, Sato, Tadatoshi, additional, Brooks, Daniel J, additional, Bouxsein, Mary L, additional, Martins, Janaina da Silva, additional, Wang, Jinhua, additional, Gray, Nathanael S, additional, Misof, Barbara, additional, Roschger, Paul, additional, Blouin, Stephane, additional, Klaushofer, Klaus, additional, Velduis-Vlug, Annegreet, additional, Vegting, Yosta, additional, Rosen, Clifford J, additional, O'Connell, Daniel, additional, Sundberg, Thomas B, additional, Xavier, Ramnik J, additional, Ung, Peter, additional, Schlessinger, Avner, additional, Kronenberg, Henry M, additional, Berdeaux, Rebecca, additional, Foretz, Marc, additional, and Wein, Marc N, additional

Published
2021
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34. Author response: Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Author

Tang, Cheng-Chia, primary, Castro Andrade, Christian D, additional, O'Meara, Maureen J, additional, Yoon, Sung-Hee, additional, Sato, Tadatoshi, additional, Brooks, Daniel J, additional, Bouxsein, Mary L, additional, Martins, Janaina da Silva, additional, Wang, Jinhua, additional, Gray, Nathanael S, additional, Misof, Barbara, additional, Roschger, Paul, additional, Blouin, Stephane, additional, Klaushofer, Klaus, additional, Velduis-Vlug, Annegreet, additional, Vegting, Yosta, additional, Rosen, Clifford J, additional, O'Connell, Daniel, additional, Sundberg, Thomas B, additional, Xavier, Ramnik J, additional, Ung, Peter, additional, Schlessinger, Avner, additional, Kronenberg, Henry M, additional, Berdeaux, Rebecca, additional, Foretz, Marc, additional, and Wein, Marc N, additional

Published
2021
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39. Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis.

Author

Vegting Y, Jongejan A, Neele AE, Claessen N, Sela G, Prange KHM, Kers J, Roelofs JJTH, van der Heijden JW, de Boer OJ, Remmerswaal EBM, Vogt L, Bemelman FJ, de Winther MPJ, Moerland PD, and Hilhorst ML

Abstract

Background and Hypothesis: Kidney macrophage infiltration is a histological hallmark of vasculitic lesions and is strongly linked to disease activity in anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AGN). The precise mechanisms by which kidney macrophages influence local inflammation and long-term damage remain largely unknown., Methods: Here, we investigate kidney macrophage diversity using single-cell transcriptome analysis of 25 485 freshly retrieved unfrozen, high-quality kidney CD45+ immune cells from five AGN patients during active disease, a lupus nephritis and nephrectomy control. Detailed subclustering of myeloid cells was performed to identify disease-specific macrophage subtypes. Next, transcriptome differences between macrophage subsets and disease serotypes were assessed. Findings were validated by immunostainings of an extended cohort of kidney biopsies and flow cytometric analysis of peripheral blood monocytes., Results: Four main macrophage subsets were identified, including a classical monocyte-derived macrophage (MDM) subset expressing a chemotactic (CXCL2, CXCL3, CXCL8, CCL3) and pro-inflammatory (IL1β, TNF) set of markers and a osteopontin/SPP1+ lipid-associated macrophage (SPP1 LAMs) subtype exhibiting distinctive upregulation of fibrotic genesets. AGN samples revealed a markedly increased proportion of CD163+ macrophages, predominantly composed of classical MDMs, accompanied by resident-like C1Q macrophages, and SPP1 LAMs An analogous trend was observed in the expansion of peripheral blood classical monocytes during active disease. The proteinase 3 (PR3)-AGN subtype exhibited heightened classical MDM and SPP1 LAM infiltration and markers of acute inflammation, while interferon signaling and markers of chronicity were reduced compared to myeloperoxidase (MPO)-AGN., Conclusions: Our findings highlight the expression of inflammatory and fibrotic genes by kidney macrophage subsets in AGN. Classical monocyte dysregulation might contribute to inflammation in the pathogenesis of AGN. Targeting these specific monocyte/macrophage subsets may potentially control the inflammatory cascade and attenuate resulting fibrosis in AGN and kidney disease in general., (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)

Published
2024
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