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461 results on '"Vela, L."'

3. A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Agudo, P., Amado, C., Arcelus, J.I., Ballaz, A., Bascuñana, J., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Beddar Chaib, F., Botella, E., Cañas, I., Carrero-Arribas, R., Casado, I., Cerdá, P., Chasco, L., Criado, J., de Ancos, C., de Miguel, J., del Toro, J., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Domínguez, I.M., Dubois-Silva, A., Escribano, J.C., Espósito, F., Farfán-Sedano, A.I., Falgá, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García-Bragado, F., García de Herreros, M., Gavín-Blanco, O., Gil-Díaz, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., Gonzalez-Moreno, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lainez-Justo, S., A, Latorre, J, Lima, Jl, Lobo, López-De la Fuente, M., López-Jiménez, L., López-Meseguer, M., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Moisés, J., Mercado, M.I., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Morales, M.V., Nieto, J.A., Noguera-Gras, E., Núñez-Fernández, M.J., Olid-Velilla, M., Osorio, J., Otalora, S., Otero, R., Paredes-Ruiz, D., Parra, P., Parra, V., Pedrajas, J.M., Pérez-López, M., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rosa, V., Rodríguez-Cobo, A., Rodríguez-Matute, C., Ruiz-Artacho, P., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suárez-Rodríguez, B., Suriñach, J.M., Tiberio, G., Torres, M.I., Torres-Sánchez, A., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M.M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., El Harake, S., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Dentali, F., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Kigitovica, D., Rusa, E., Skride, A., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Sarlon-Bartoli, Gabrielle, Criado, Juan, Middeldorp, Saskia, Nieto, José Antonio, Díaz-Pedroche, María del Carmen, Moustafa, Farès, Ruiz-Giménez, Nuria, and DI Micco, Pierpaolo

Published
2023
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4. COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding

Author

Adarraga, M.D., Alberich-Conesa, A., Amado, C., Amorós, S., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Botella, E., Carrero, R., Casado, I., Criado, J., del Toro, J., De Ancos, C., De Juana-Izquierdo, C., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Espósito, F., Falgá, C., Farfán-Sedano, A.I., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García de Herreros, M., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gil-Hernández, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., González-Martínez, J., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lalueza, A., Lainez-Justo, S., Lecumberri, R., León-Ramírez, J.M., Lobo, J.L., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Ruiz, A., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Mas-Maresma, L., Marcos, M., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Nieto, J.A., Núñez-Fernández, M.J., Osorio, J., Otalora, S., Pacheco-Gómez, N., Paredes-Ruiz, D., Parra, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Jacoiste, A., Pérez-Pérez, J.L., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rubio, C.M., Rosa, V., Rodríguez-Cobo, A., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suriñach, J.M., Tiberio, G., Tolosa, C., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, J.R., Vela, L., Vidal, G., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Grange, C., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Najib, D., Tzoran, I., Farrashi, M., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Scarinzi, P., Siniscalchi, C., Taflaj, B., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Demelo-Rodriguez, Pablo, Alonso-Beato, Rubén, Jara-Palomares, Luis, Galeano-Valle, Francisco, Bura-Riviere, Alessandra, Visonà, Adriana, Francisco, Iria, Vidal, Gemma, López-Ruiz, Antonio, and Monreal, Manuel

Published
2023
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5. Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Alberich-Conesa, A., Alonso-Carrillo, J., Amado, C., Amorós, S., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Botella, E., Casado, I., Chasco, L., Cerdà, P., Criado, J., del Toro, J., De Juana-Izquierdo, C., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Espósito, F., Falgá, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Fidalgo, M.A., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García de Herreros, M., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., González-Martínez, J., González-Moreno, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lainez-Justo, S., Lalueza, A., Latorre, A., Lecumberri, R., Lobo, J.L., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Ruiz, A., López-Sáez, J.B., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Marcos, M., Martín-Martos, F., Mellado, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Morales, M.V., Nieto, J.A., Noguera-Gras, E., Núñez-Fernández, M.J., Osorio, J., Otalora, S., Pacheco-Gómez, N., Paredes-Ruiz, D., Parra, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Jacoiste, M.A., Pérez-Pérez, J.L., Peris, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rosa, V., Rodríguez-Cobo, A., Ruiz-Giménez, N., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suriñach, J.M., Tiberio, G., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M.M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., De Angelis, A., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Scarinzi, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Gibietis, V., Kigitovica, D., Skride, A., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Cohen, Omri, Barg, Assaf A., Nowak-Göttl, Ulrike, Amado-Fernández, Cristina, Mazzolai, Lucia, Tiberio, Gregorio, Skride, Andris, Morales, María del Valle, and Kenet, Gili

Published
2023
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6. Heart Rate and Mortality in Patients With Acute Symptomatic Pulmonary Embolism

Author

Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Verhamme, Peter, Caprini, Joseph A., Bui, Hanh My, Adarraga, M.D., Aibar, J., Aibar, M.A., Alonso, J., Amado, C., Arcelus, J.I., Asuero, A., Azcarate-Agüero, P., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Beddar Chaib, F., Camon, A.M., Castro, J., Chasco, L., Criado, J., de Ancos, C., del Toro, J., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Di Campli, M.V., Dubois-Silva, A., Escribano, J.C., Espósito, F., Farfán-Sedano, A.I., Fernández-Capitán, C., Fernández-Reyes, J.L., Fidalgo, M.A., Flores, K., Font, C., Font, L., Francisco, I., Gabara, C., Galeano-Valle, F., García, M.A., García-Bragado, F., García de Herreros, M., García de la Garza, R., García-Díaz, C., Gil-Díaz, A., Gómez-Cuervo, C., Giménez-Suau, M., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jiménez-Alfaro, C., Joya, M.D., Lainez-Justo, S., Latorre, A., Lima, J., Lobo, J.L., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Sáez, J.B., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P.J., Martín del Pozo, M., Martín-Martos, F., Martínez-Urbistondo, D., Mella, C., Mercado, M.I., Moisés, J., Monreal, M., Muñoz, M., Muñoz-Blanco, A., Nieto, J.A., Nofuentes-Pérez, E., Núñez-Fernández, M.J., Olid-Velilla, M., Olivares, M.C., Osorio, J., Otalora, S., Otero, R., Pedrajas, J.M., Pellejero, G., Porras, J.A., Portillo, J., Rodríguez-Matute, C., Rosa, V., Ruiz-Artacho, P., Ruiz-Ruiz, J., Salgueiro, G., Sánchez-Martínez, R., Sánchez-Muñoz-Torrero, J.F., Sancho, T., Soler, S., Suárez-Rodríguez, B., Suriñach, J.M., Torres, M.I., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Varona, J.F., Vela, L., Vela, J.R., Vidal, G., Villalobos, A., Villares, P., Zamora, C., Ay, C., Nopp, S., Pabinger, I., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Malý, R., Accassat, S., Ait Abdallah, N., Bertoletti, L., Bura-Riviere, A., Catella, J., Couturaud, F., Crichi, B., Debourdeau, P., Espitia, O., Farge-Bancel, D., Grange, C., Helfer, H., Lacut, K., Le Mao, R., Mahé, I., Morange, P., Moustafa, F., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Quere, I., Schellong, S., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Nishimoto, Y., Sato, Y., Birzulis, J., Skride, A., Zaicenko, A., Fonseca, S., Martins, F., Meireles, J., Bosevski, M., Krstevski, G., Bounameaux, H., Mazzolai, L., Bikdeli, B., Caprini, J.A., Bui, H.M., Jaureguízar, Ana, Jiménez, David, Bikdeli, Behnood, Ruiz-Artacho, Pedro, Muriel, Alfonso, Tapson, Victor, López-Reyes, Raquel, Valero, Beatriz, and Kenet, Gili

Published
2022
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7. Symptomatic subsegmental versus more central pulmonary embolism: Clinical outcomes during anticoagulation

Author

Fernández‐Capitán, Carmen, Rodriguez Cobo, Ana, Jiménez, David, Madridano, Olga, Ciammaichella, Maurizio, Usandizaga, Esther, Otero, Remedios, Di Micco, Pierpaolo, Moustafa, Farès, Monreal, Manuel, Adarraga, M.D., Aibar, M.A., Alfonsa, M., Arcelus, J.I., Azcarate‐Agüero, P., Ballaz, A., Baños, P., Barba, R., Barrón, M., Barrón‐Andrés, B., Bascuñana, J., Blanco‐Molina, A., Camón, A.M., Chasco, L., Cruz, A.J., del Pozo, R., de Miguel, J., del Toro, J., Díaz‐Pedroche, M.C., Díaz‐Peromingo, J.A., Escribano, J.C., Falgá, C., Fernández‐Aracil, C., Fidalgo, M.A., Font, C., Font, L., García, M.A., García‐Bragado, F., García‐Morillo, M., García‐Raso, A., García‐Sánchez, A.I., Gavín, O., Gaya, I., Gómez, C., Gómez, V., González, J., Grau, E., Guijarro, R., Gutiérrez, J., Hernández‐Comes, G., Hernández‐Blasco, L., Hernando, E., Jara‐Palomares, L., Jaras, M.J., Jiménez, D., Joya, M.D., Lima, J., Llamas, P., Lobo, J.L., López‐Reyes, R., López‐Sáez, J.B., Lorente, M.A., Lorenzo, A., Lumbierres, M., Maestre, A., Marchena, P.J., Martín‐Martos, F., Martín‐Romero, M., Morales, M.V., Nieto, J.A., Nieto, S., Núñez, A., Núñez, M.J., Odriozola, M., Olivares, M.C., Otalora, S., Pedrajas, J.M., Pellejero, G., Pérez‐Ductor, C., Peris, M.L., Pons, I., Porras, J.A., Ramírez, L., Reig, O., Riera‐Mestre, A., Riesco, D., Rivas, A., Rodríguez‐Dávila, M.A., Rosa, V., Ruiz‐Artacho, P., Sahuquillo, J.C., Sala‐Sainz, M.C., Sampériz, A., Sánchez‐Martínez, R., Soler, S., Sopeña, B., Suriñach, J.M., Tolosa, C., Torres, M.I., Troya, J., Trujillo‐Santos, J., Uresandi, F., Valero, B., Valle, R., Vela, J., Vela, L., Vidal, G., Villalobos, A., Vanassche, T., Vandenbriele, C., Verhamme, P., Yoo, H.H.B., Wells, P., Hirmerova, J., Malý, R., Salgado, E., Bertoletti, L., Bura‐Riviere, A., Falvo, N., Farge‐Bancel, D., Hij, A., Mahé, I., Quere, I., Braester, A., Brenner, B., Ellis, M., Tzoran, I., Antonucci, G., Barillari, G., Bilora, F., Bortoluzzi, C., Bucherini, E., Camerota, A., Cattabiani, C., Dentali, F., Duce, R., Giorgi‐Pierfranceschi, M., Grandone, E., Imbalzano, E., Lessiani, G., Maida, R., Mastroiacovo, D., Pace, F., Pesavento, R., Pesavento, M., Poggio, R., Prandoni, P., Quintavalla, R., Rocci, A., Siniscalchi, C., Tiraferri, E., Tonello, D., Visonà, A., Zalunardo, B., Gibietis, V., Skride, A., Vitola, B., Alatri, A., Bounameaux, H., Calanca, L., and Mazzolai, L.

Published
2021
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8. Microstructural and kinetics analysis of FeB–Fe2B layer grown by pulsed-DC powder-pack boriding on AISI 316 L steel.

Author

Campos-Silva, I., Cedeño-Velázquez, J., Contla-Pacheco, A. D., Arzate-Vázquez, I., Castillo-Vela, L. E., Olivares-Luna, M., Rosales-Lopez, J. L., and Espino-Cortes, F. P.

Subjects
ORDINARY differential equations, YOUNG'S modulus, UMPOLUNG, BORIDING, DIFFUSION coefficients
Abstract

In this study, novel findings were obtained regarding the influence of a 10 A current intensity on the growth of an FeB–Fe2B layer during pulsed-DC powder-pack boriding. Boride layer formation was carried out on AISI 316 L steel at 1123–1223 K for different exposure times at each temperature, considering 10 s polarity inversion cycles. The boride layer was characterized by x-ray diffraction and high-speed Berkovich nanoindentation, the latter being used to determine the hardness and reduced Young's modulus mappings along the depth of the layer-substrate system. Moreover, the growth kinetics of the FeB–Fe2B layer on the steel's surface was modeled using the heat balance integral method (HBIM). This involved transforming Fick's second law into ordinary differential equations over time, assuming a quadratic boron concentration profile in space to determine the B diffusion coefficients in FeB and Fe2B, respectively. From the Arrhenius relationship, the B activation energies in the boride layer were estimated considering the contribution of the electromigration effect; the results showed an approximately 30% reduction compared to the values obtained in the conventional powder-pack boriding for AISI 316 L steel. Finally, the theoretical layer thickness obtained by the HBIM demonstrated an error of no more than 5% against the experimental FeB and FeB + Fe2B layer thickness values. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Quality of life and non-motor symptoms in Parkinson's disease patients with subthreshold depression

Author

Santos-García, D., de Deus Fonticoba, T., Suárez Castro, E., Aneiros Díaz, A., Cores Bartolomé, C., Feal Panceiras, M.J., Paz González, J.M., Valdés Aymerich, L., García Moreno, J.M., Blázquez Estrada, M., Jesús, S., Mir, P., Aguilar, M., Planellas, L.L., García Caldentey, J., Caballol, N., Legarda, I., Cabo López, I., López Manzanares, L., Ávila Rivera, M.A., Catalán, M.J., López Díaz, L.M., Borrué, C., Álvarez Sauco, M., Vela, L., Cubo, E., Martínez Castrillo, J.C., Sánchez Alonso, P., Alonso Losada, M.G., López Ariztegui, N., Gastón, I., Pascual-Sedano, B., Seijo, M., Ruíz Martínez, J., Valero, C., Kurtis, M., González Ardura, J., Prieto Jurczynska, C., and Martinez-Martin, P.

Published
2020
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10. Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort

Author

Adarmes, A.D., Almeria, M., Alonso Losada, G., Alonso Cánovas, A., Alonso-Frech, F., Arribas, S., Ascunde Vidondo, A., Aquilar, M., Ávila, M.A., Bernardo Lambrich, N., Bejr-Kasem, H., Blázquez Estrada, M., Botí, M., Cabello González, C., Cabo López, I., Caballol, N., Cámara Lorenzo, A., Carrillo, F., Catalán, M.J., Clavero, P., Cortina Fernández, A., Crespo Cuevas, A., de Fábregues-Boixar, O., Díez-Fairen, M., Erro, E., Estelrich Peyret, E., Fernández Guillán, N., Gámez, P., Gallego, M., García Caldentey, J., García Campos, C., García Moreno, J.M., Gastón, I., Gómez Garre, M.P., González Aloy, J., González-Aramburu, I., González Ardura, J., González García, B., González Palmás, M.J., González Toledo, G.R., Golpe Díaz, A., Grau Solá, M., Guardia, G., Hernández-Vara, J., Horta Barba, A., Infante, J., Jesús, S., Kulisevsky, J., Kurtis, M., Labandeira, C., Labrador, M.A., Lacruz, F., Lage Castro, M., Legarda, I., López Ariztegui, N., López Díaz, L.M., López Manzanares, L., López Seoane, B., Martí Andres, G., Martí, M.J., Martínez-Castrillo, J.C., McAfee, D., Meitín, M.T., Menéndez González, M., Méndez del Barrio, C., Miranda Santiago, J., Morales Casado, M.I., Moreno Diéguez, A., Nogueira, V., Novo Amado, A., Novo Ponte, S., Ordás, C., Pagonabarraga, J., Pareés, I., Pascual-Sedano, B., Pastor, P., Pérez Fuertes, A., Pérez Noguera, R., Planellas, Ll, Pol Fuster, J., Prats, M.A., Prieto Jurczynska, C., Puente, V., Redondo Rafales, N., Rodríguez Méndez, L., Roldán, F., Ruíz De Arcos, M., Ruíz Martínez, J., Sánchez Alonso, P., Sánchez-Carpintero, M., Sánchez Díez, G., Sánchez Rodríguez, A., Santacruz, P., Segundo Rodríguez, J.C., Seijo, M., Serarols, A., Sierra Peña, M., Tartari, J.P., Vargas, L., Vázquez Gómez, R., Villanueva, C., Vives, B., Villar, M.D., Santos García, D., de Deus Fonticoba, T., Suárez Castro, E., Borrué, C., Mata, M., Solano Vila, B., Cots Foraster, A., Álvarez Sauco, M., Rodríguez Pérez, A.B., Vela, L., Macías, Y., Escalante, S., Esteve, P., Reverté Villarroya, S., Cubo, E., Casas, E., Arnaiz, S., Carrillo Padilla, F., Pueyo Morlans, M., Mir, P., and Martinez-Martin, P.

Published
2019
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11. A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism

Author

Sarlon-Bartoli, Gabrielle, primary, Criado, Juan, additional, Middeldorp, Saskia, additional, Nieto, José Antonio, additional, Díaz-Pedroche, María del Carmen, additional, Moustafa, Farès, additional, Ruiz-Giménez, Nuria, additional, Brenner, Benjamin, additional, Monreal, Manuel, additional, DI Micco, Pierpaolo, additional, Prandoni, Paolo, additional, Farge-Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, M.D., additional, Agudo, P., additional, Amado, C., additional, Arcelus, J.I., additional, Ballaz, A., additional, Bascuñana, J., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Blanco-Molina, A., additional, Beddar Chaib, F., additional, Botella, E., additional, Cañas, I., additional, Carrero-Arribas, R., additional, Casado, I., additional, Cerdá, P., additional, Chasco, L., additional, Criado, J., additional, de Ancos, C., additional, de Miguel, J., additional, del Toro, J., additional, Demelo-Rodríguez, P., additional, Díaz-Brasero, A.M., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Domínguez, I.M., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Espósito, F., additional, Farfán-Sedano, A.I., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Fernández-Jiménez, B., additional, Fernández-Muixi, J., additional, Fernández-Reyes, J.L., additional, Font, C., additional, Francisco, I., additional, Galeano-Valle, F., additional, García, M.A., additional, García-Bragado, F., additional, García de Herreros, M., additional, Gavín-Blanco, O., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, Gómez-Mosquera, A.M., additional, Gonzalez-Moreno, M., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jou, I., additional, Joya, M.D., additional, Lacruz, B., additional, Lainez-Justo, S., additional, A, Latorre, additional, J, Lima, additional, Jl, Lobo, additional, López-De la Fuente, M., additional, López-Jiménez, L., additional, López-Meseguer, M., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Reyes, R., additional, López-Sáez, J.B., additional, Lorente, M.A., additional, Lorenzo, A., additional, Madridano, O., additional, Maestre, A., additional, Marchena, P.J., additional, Martín-Guerra, J.M., additional, Martín-Martos, F., additional, Mellado, M., additional, Mena, E., additional, Moisés, J., additional, Mercado, M.I., additional, Monreal, M., additional, Muñoz-Blanco, A., additional, Muñoz-Gamito, G., additional, Morales, M.V., additional, Nieto, J.A., additional, Noguera-Gras, E., additional, Núñez-Fernández, M.J., additional, Olid-Velilla, M., additional, Osorio, J., additional, Otalora, S., additional, Otero, R., additional, Paredes-Ruiz, D., additional, Parra, P., additional, Parra, V., additional, Pedrajas, J.M., additional, Pérez-López, M., additional, Peris, M.L., additional, Pesce, M.L., additional, Porras, J.A., additional, Poyo-Molina, J., additional, Puchades, R., additional, Riera-Mestre, A., additional, Rivera-Civico, F., additional, Rivera-Gallego, A., additional, Roca, M., additional, Rosa, V., additional, Rodríguez-Cobo, A., additional, Rodríguez-Matute, C., additional, Ruiz-Artacho, P., additional, Ruiz-Giménez, N., additional, Ruiz-Ruiz, J., additional, Salgueiro, G., additional, Sancho, T., additional, Sendín, V., additional, Sigüenza, P., additional, Soler, S., additional, Suárez-Rodríguez, B., additional, Suriñach, J.M., additional, Tiberio, G., additional, Torres, M.I., additional, Torres-Sánchez, A., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Usandizaga, E., additional, Valle, R., additional, Varona, J.F., additional, Vela, L., additional, Vela, J.R., additional, Villalobos, A., additional, Villares, P., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Engelen, M.M., additional, Martens, C., additional, Verhamme, P., additional, Yoo, H.H.B., additional, Arguello, J.D., additional, Montenegro, A.C., additional, Roa, J., additional, Hirmerova, J., additional, Malý, R., additional, Accassat, S., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Chopard, R., additional, Couturaud, F., additional, Espitia, O., additional, El Harake, S., additional, Le Mao, R., additional, Mahé, I., additional, Moustafa, F., additional, Plaisance, L., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Versini, E., additional, Schellong, S., additional, Braester, A., additional, Brenner, B., additional, Kenet, G., additional, Tzoran, I., additional, Sadeghipour, P., additional, Basaglia, M., additional, Bilora, F., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Ciammaichella, M., additional, De Angelis, A., additional, Dentali, F., additional, Di Micco, P., additional, Imbalzano, E., additional, Merla, S., additional, Pesavento, R., additional, Prandoni, P., additional, Siniscalchi, C., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Kigitovica, D., additional, Rusa, E., additional, Skride, A., additional, Fonseca, S., additional, Manuel, M., additional, Meireles, J., additional, Bosevski, M., additional, Eftimova, A., additional, Zdraveska, M., additional, Bounameaux, H., additional, Mazzolai, L., additional, Aujayeb, A., additional, Caprini, J.A., additional, Weinberg, I., additional, and Bui, H.M., additional

Published
2023
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13. Venous thromboembolism characteristics, treatment and outcomes in young adults: findings from the Registro Informatizado de Enfermedad TromboEmbólica registry

Author

Cohen, Omri, primary, Barg, Assaf A., additional, Nowak-Göttl, Ulrike, additional, Amado-Fernández, Cristina, additional, Mazzolai, Lucia, additional, Tiberio, Gregorio, additional, Schellong, Sebastian, additional, Skride, Andris, additional, Morales, María del Valle, additional, Monreal, Manuel, additional, Kenet, Gili, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge-Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, M.D., additional, Alberich-Conesa, A., additional, Alonso-Carrillo, J., additional, Amado, C., additional, Amorós, S., additional, Arcelus, J.I., additional, Ballaz, A., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Blanco-Molina, A., additional, Botella, E., additional, Casado, I., additional, Chasco, L., additional, Cerdà, P., additional, Criado, J., additional, del Toro, J., additional, De Juana-Izquierdo, C., additional, Demelo-Rodríguez, P., additional, Díaz-Brasero, A.M., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Espósito, F., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Fernández-Jiménez, B., additional, Fernández-Muixi, J., additional, Fernández-Reyes, J.L., additional, Fidalgo, M.A., additional, Font, C., additional, Francisco, I., additional, Galeano-Valle, F., additional, García, M.A., additional, García de Herreros, M., additional, García-Bragado, F., additional, García-Ortega, A., additional, Gavín-Sebastián, O., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, Gómez-Mosquera, A.M., additional, González-Martínez, J., additional, González-Moreno, M., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jou, I., additional, Joya, M.D., additional, Lacruz, B., additional, Lainez-Justo, S., additional, Lalueza, A., additional, Latorre, A., additional, Lecumberri, R., additional, Lobo, J.L., additional, López-De la Fuente, M., additional, López-Jiménez, L., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Ruiz, A., additional, López-Sáez, J.B., additional, Lorenzo, A., additional, Lumbierres, M., additional, Madridano, O., additional, Maestre, A., additional, Marcos, M., additional, Martín-Martos, F., additional, Mellado, M., additional, Mena, E., additional, Mercado, M.I., additional, Moisés, J., additional, Monreal, M., additional, Muñoz-Blanco, A., additional, Muñoz-Gamito, G., additional, Morales, M.V., additional, Nieto, J.A., additional, Noguera-Gras, E., additional, Núñez-Fernández, M.J., additional, Osorio, J., additional, Otalora, S., additional, Pacheco-Gómez, N., additional, Paredes-Ruiz, D., additional, Parra, P., additional, Pedrajas, J.M., additional, Pérez-Ductor, C., additional, Pérez-Jacoiste, M.A., additional, Pérez-Pérez, J.L., additional, Peris, M.L., additional, Porras, J.A., additional, Poyo-Molina, J., additional, Puchades, R., additional, Riera-Mestre, A., additional, Rivera-Civico, F., additional, Rivera-Gallego, A., additional, Roca, M., additional, Rosa, V., additional, Rodríguez-Cobo, A., additional, Ruiz-Giménez, N., additional, Salgueiro, G., additional, Sancho, T., additional, Sendín, V., additional, Sigüenza, P., additional, Soler, S., additional, Suriñach, J.M., additional, Tiberio, G., additional, Torres, M.I., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Usandizaga, E., additional, Valle, R., additional, Varona, J.F., additional, Vela, L., additional, Vela, J.R., additional, Villalobos, A., additional, Villares, P., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Engelen, M.M., additional, Martens, C., additional, Verhamme, P., additional, Yoo, H.H.B., additional, Arguello, J.D., additional, Montenegro, A.C., additional, Roa, J., additional, Hirmerova, J., additional, Malý, R., additional, Accassat, S., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Chopard, R., additional, Couturaud, F., additional, Espitia, O., additional, Leclercq, B., additional, Le Mao, R., additional, Mahé, I., additional, Moustafa, F., additional, Plaisance, L., additional, Poenou, G., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Versini, E., additional, Schellong, S., additional, Braester, A., additional, Brenner, B., additional, Kenet, G., additional, Tzoran, I., additional, Sadeghipour, P., additional, Basaglia, M., additional, Bilora, F., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Ciammaichella, M., additional, Colaizzo, D., additional, De Angelis, A., additional, Dentali, F., additional, Di Micco, P., additional, Grandone, E., additional, Imbalzano, E., additional, Merla, S., additional, Pesavento, R., additional, Prandoni, P., additional, Scarinzi, P., additional, Siniscalchi, C., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Gibietis, V., additional, Kigitovica, D., additional, Skride, A., additional, Fonseca, S., additional, Manuel, M., additional, Meireles, J., additional, Bosevski, M., additional, Bounameaux, H., additional, Mazzolai, L., additional, Aujayeb, A., additional, Caprini, J.A., additional, Weinberg, I., additional, and Bui, H.M., additional

Published
2023
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16. Clinical outcomes during anticoagulant therapy in fragile patients with venous thromboembolism

Author

Moustafa, Farès, Giorgi Pierfranceschi, Matteo, Di Micco, Pierpaolo, Bucherini, Eugenio, Lorenzo, Alicia, Villalobos, Aurora, Nieto, José A., Valero, Beatriz, Sampériz, Ángel L., Monreal, Manuel, Decousus, Hervé, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Bertoletti, Laurent, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Papadakis, Manolis, Adarraga, MD, Agudo, P, Aibar, MA, Alfonso, M, Arcelus, JI, Ballaz, A, Barba, R, Barrón, M, Barrón‐Andrés, B, Bascuñana, J, Blanco‐Molina, A, Cañas, I, Casado, I, Chic, N, del Pozo, R, del Toro, J, Díaz‐Pedroche, MC, Díaz‐Peromingo, JA, Falgá, C, Fernández‐Aracil, C, Fernández‐Capitán, C, Fidalgo, MA, Font, C, Font, L, Gallego, P, García, MA, García‐Bragado, F, Gavín, O, Gómez, C, Gómez, V, González, J, Grau, E, Grimón, A, Guijarro, R, Guirado, L, Gutiérrez, J, Hernández‐Comes, G, Hernández‐Blasco, L, Jara‐Palomares, L, Jaras, MJ, Jiménez, D, Jiménez, J, Joya, MD, Llamas, P, Lobo, JL, López, P, López‐Jiménez, L, López‐Reyes, R, López‐Sáez, JB, Lorente, MA, Lumbierres, M, Luque, JM, Marchena, PJ, Martín‐Martos, F, Mellado, M, Nieto, S, Núñez, A, Núñez, MJ, Otalora, S, Otero, R, Pedrajas, JM, Pérez, G, Pérez‐Ductor, C, Peris, ML, Pons, I, Porras, JA, Reig, O, Riera‐Mestre, A, Riesco, D, Rivas, A, Rodríguez, M, Rodríguez‐Dávila, MA, Rosa, V, Rosillo‐Hernández, E, Ruiz‐Artacho, P, Ruiz‐Giménez, N, Sahuquillo, JC, Sala‐Sainz, MC, Sánchez‐Martínez, R, Sanz, O, Soler, S, Sopeña, B, Suriñach, JM, Tolosa, C, Torres, MI, Troya, J, Trujillo‐Santos, J, Uresandi, F, Usandizaga, E, Valle, R, Vela, J, Vela, L, Vicente, MP, Xifre, B, Vanassche, T, Verhamme, P, Yoo, HHB, Wells, P, Hirmerova, J, Malý, R, Dulíček, P, Salgado, E, Bertoletti, L, Bura‐Riviere, A, Farge‐Bancel, D, Hij, A, Mahé, I, Merah, A, Braester, A, Brenner, B, Tzoran, I, Antonucci, G, Barillari, G, Bilora, F, Bortoluzzi, C, Brandolin, B, Cattabiani, C, Ciammaichella, M, Dell'Elce, N, Dentali, F, Duce, R, Grandone, E, Imbalzano, E, Lessiani, G, Maida, R, Mastroiacovo, D, Pace, F, Parisi, R, Pellegrinet, M, Pesavento, R, Pinelli, M, Poggio, R, Prandoni, P, Quintavalla, R, Rocci, A, Tiraferri, E, Tonello, D, Tufano, A, Visonà, A, Gibietis, V, Skride, A, Vitola, B, Bosevski, M, Zdraveska, M, Bounameaux, H, and Mazzolai, L

Published
2017
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18. Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X

Author

Pedersen, T, Abramovic, I, Agostinetti, P, Torres, M, Akaslompolo, S, Belloso, J, Aleynikov, P, Aleynikova, K, Alhashimi, M, Ali, A, Allen, N, Alonso, A, Anda, G, Andreeva, T, Angioni, C, Arkhipov, A, Arnold, A, Asad, W, Ascasibar, E, Aumeunier, M, Avramidis, K, Aymerich, E, Baek, S, Bahner, J, Baillod, A, Balden, M, Baldzuhn, J, Ballinger, S, Banduch, M, Bannmann, S, Navarro, A, Barbui, T, Beidler, C, Belafdil, C, Bencze, A, Benndorf, A, Beurskens, M, Biedermann, C, Biletskyi, O, Blackwell, B, Blatzheim, M, Bluhm, T, Bockenhoff, D, Bongiovi, G, Borchardt, M, Borodin, D, Boscary, J, Bosch, H, Bosmann, T, Boswirth, B, Bottger, L, Bottino, A, Bozhenkov, S, Brakel, R, Brandt, C, Brauer, T, Braune, H, Brezinsek, S, Brunner, K, Buller, S, Burhenn, R, Bussiahn, R, Buttenschon, B, Buzas, A, Bykov, V, Calvo, I, Mata, K, Caminal, I, Cannas, B, Cappa, A, Carls, A, Carovani, F, Carr, M, Carralero, D, Carvalho, B, Casas, J, Castano-Bardawil, D, Castejon, F, Chaudhary, N, Chelis, I, Chomiczewska, A, Coenen, J, Cole, M, Cordella, F, Corre, Y, Crombe, K, Cseh, G, Csillag, B, Damm, H, Day, C, de Baar, M, De la Cal, E, Degenkolbe, S, Demby, A, Denk, S, Dhard, C, Di Siena, A, Dinklage, A, Dittmar, T, Dreval, M, Drevlak, M, Drewelow, P, Drews, P, Dunai, D, Edlund, E, Effenberg, F, Ehrke, G, Endler, M, Ennis, D, Escoto, F, Estrada, T, Fable, E, Fahrenkamp, N, Fanni, A, Faustin, J, Fellinger, J, Feng, Y, Figacz, W, Flom, E, Ford, O, Fornal, T, Frerichs, H, Freundt, S, Fuchert, G, Fukuyama, M, Fullenbach, F, Gantenbein, G, Gao, Y, Garcia, K, Regana, J, Garcia-Cortes, I, Gaspar, J, Gates, D, Geiger, J, Geiger, B, Giudicotti, L, Gonzalez, A, Goriaev, A, Gradic, D, Grahl, M, Graves, J, Green, J, Grelier, E, Greuner, H, Gross, S, Grote, H, Groth, M, Gruca, M, Grulke, O, Grun, M, Arnaiz, J, Gunter, S, Haak, V, Haas, M, Hacker, P, Hakola, A, Hallenbert, A, Hammond, K, Han, X, Hansen, S, Harris, J, Hartfuss, H, Hartmann, D, Hathiramani, D, Hatzky, R, Hawke, J, Hegedus, S, Hein, B, Heinemann, B, Helander, P, Henneberg, S, Hergenhahn, U, Hidalgo, C, Hindenlang, F, Hirsch, M, Hofel, U, Hollfeld, K, Holtz, A, Hopf, D, Hoschen, D, Houry, M, Howard, J, Huang, X, Hubeny, M, Hudson, S, Ida, K, Igitkhanov, Y, Igochine, V, Illy, S, Ionita-Schrittwieser, C, Isobe, M, Jablczynska, M, Jablonski, S, Jagielski, B, Jakubowski, M, van Vuuren, A, Jelonnek, J, Jenko, F, Jensen, T, Jenzsch, H, Junghanns, P, Kaczmarczyk, J, Kallmeyer, J, Kamionka, U, Kandler, M, Kasilov, S, Kazakov, Y, Kennedy, D, Kharwandikar, A, Khokhlov, M, Kiefer, C, Killer, C, Kirschner, A, Kleiber, R, Klinger, T, Klose, S, Knauer, J, Knieps, A, Kochl, F, Kocsis, G, Kolesnichenko, Y, Konies, A, Konig, R, Kontula, J, Kornejew, P, Koschinsky, J, Kozulia, M, Kramer-Flecken, A, Krampitz, R, Krause, M, Krawczyk, N, Kremeyer, T, Krier, L, Kriete, D, Krychowiak, M, Ksiazek, I, Kubkowska, M, Kuczynski, M, Kuhner, G, Kumar, A, Kurki-Suonio, T, Kwak, S, Landreman, M, Lang, P, Langenberg, A, Laqua, H, Laube, R, Lazerson, S, Lewerentz, M, Li, C, Liang, Y, Linsmeier, C, Lion, J, Litnovsky, A, Liu, S, Lobsien, J, Loizu, J, Lore, J, Lorenz, A, Losada, U, Louche, F, Lunsford, R, Lutsenko, V, Machielsen, M, Mackel, F, Maisano-Brown, J, Maj, O, Makowski, D, Manduchi, G, Maragkoudakis, E, Marchuk, O, Marsen, S, Martines, E, Martinez-Fernandez, J, Marushchenko, M, Masuzaki, S, Maurer, D, Mayer, M, Mccarthy, K, Mccormack, O, Mcneely, P, Meister, H, Mendelevitch, B, Mendes, S, Merlo, A, Messian, A, Mielczarek, A, Mishchenko, O, Missal, B, Mitteau, R, Moiseenko, V, Mollen, A, Moncada, V, Monnich, T, Morisaki, T, Moseev, D, Motojima, G, Mulas, S, Mulsow, M, Nagel, M, Naujoks, D, Naulin, V, Neelis, T, Neilson, H, Neu, R, Neubauer, O, Neuner, U, Nicolai, D, Nielsen, S, Niemann, H, Nishiza, T, Nishizawa, T, Nuhrenberg, C, Ochoukov, R, Oelmann, J, Offermanns, G, Ogawa, K, Okamura, S, Olmanns, J, Ongena, J, Oosterbeek, J, Otte, M, Pablant, N, Alvarez, N, Pandey, A, Pasch, E, Pavlichenko, R, Pavone, A, Pawelec, E, Pechstein, G, Pelka, G, Perseo, V, Peterson, B, Pilopp, D, Pingel, S, Pisano, F, Plockl, B, Plunk, G, Poloskei, P, Pompe, B, Popov, A, Porkolab, M, Proll, J, Pueschel, M, Puiatti, M, Sitjes, A, Purps, F, Rahbarnia, K, Rasinski, M, Rasmussen, J, Reiman, A, Reimold, F, Reisner, M, Reiter, D, Richou, M, Riedl, R, Riemann, J, Risse, K, Roberg-Clark, G, Rohde, V, Romazanov, J, Rondeshagen, D, Rong, P, Rudischhauser, L, Rummel, T, Rummel, K, Runov, A, Rust, N, Ryc, L, Salembier, P, Salewski, M, Sanchez, E, Satake, S, Satheeswaran, G, Schacht, J, Scharff, E, Schauer, F, Schilling, J, Schlisio, G, Schmid, K, Schmitt, J, Schmitz, O, Schneider, W, Schneider, M, Schneider, P, Schrittwieser, R, Schroder, T, Schroder, M, Schroeder, R, Schweer, B, Schworer, D, Scott, E, Shanahan, B, Sias, G, Sichta, P, Singer, M, Sinha, P, Siplia, S, Slaby, C, Sleczka, M, Smith, H, Smoniewski, J, Sonnendrucker, E, Spolaore, M, Spring, A, Stadler, R, Stanczak, D, Stange, T, Stepanov, I, Stephey, L, Stober, J, Stroth, U, Strumberger, E, Suzuki, C, Suzuki, Y, Svensson, J, Szabolics, T, Szepesi, T, Szucs, M, Tabares, F, Tamura, N, Tancetti, A, Tantos, C, Terry, J, Thienpondt, H, Thomsen, H, Thumm, M, Travere, J, Traverso, P, Tretter, J, Trier, E, Mora, H, Tsujimura, T, Turkin, Y, Tykhyi, A, Unterberg, B, van Eeten, P, van Milligen, B, van Schoor, M, Vano, L, Varoutis, S, Vecsei, M, Vela, L, Velasco, J, Vervier, M, Vianello, N, Viebke, H, Vilbrandt, R, Vogel, G, Vogt, N, Volkhausen, C, von Stechow, A, Wagner, F, Wang, E, Wang, H, Warmer, F, Wauters, T, Wegener, L, Wegner, T, Weir, G, Wenzel, U, White, A, Wilde, F, Wilms, F, Windisch, T, Winkler, M, Winter, A, Winters, V, Wolf, R, Wright, A, Wurden, G, Xanthopoulos, P, Xu, S, Yamada, H, Yamaguchi, H, Yokoyama, M, Yoshinuma, M, Yu, Q, Zamanov, M, Zanini, M, Zarnstorff, M, Zhang, D, Zhou, S, Zhu, J, Zhu, C, Zilker, M, Zocco, A, Zohm, H, Zoletnik, S, Zsuga, L, Pedersen T. S., Abramovic I., Agostinetti P., Torres M. A., Akaslompolo S., Belloso J. A., Aleynikov P., Aleynikova K., Alhashimi M., Ali A., Allen N., Alonso A., Anda G., Andreeva T., Angioni C., Arkhipov A., Arnold A., Asad W., Ascasibar E., Aumeunier M. -H., Avramidis K., Aymerich E., Baek S. -G., Bahner J., Baillod A., Balden M., Baldzuhn J., Ballinger S., Banduch M., Bannmann S., Navarro A. B., Barbui T., Beidler C., Belafdil C., Bencze A., Benndorf A., Beurskens M., Biedermann C., Biletskyi O., Blackwell B., Blatzheim M., Bluhm T., Bockenhoff D., Bongiovi G., Borchardt M., Borodin D., Boscary J., Bosch H., Bosmann T., Boswirth B., Bottger L., Bottino A., Bozhenkov S., Brakel R., Brandt C., Brauer T., Braune H., Brezinsek S., Brunner K., Buller S., Burhenn R., Bussiahn R., Buttenschon B., Buzas A., Bykov V., Calvo I., Mata K. C., Caminal I., Cannas B., Cappa A., Carls A., Carovani F., Carr M., Carralero D., Carvalho B., Casas J., Castano-Bardawil D., Castejon F., Chaudhary N., Chelis I., Chomiczewska A., Coenen J. W., Cole M., Cordella F., Corre Y., Crombe K., Cseh G., Csillag B., Damm H., Day C., de Baar M., De la Cal E., Degenkolbe S., Demby A., Denk S., Dhard C., Di Siena A., Dinklage A., Dittmar T., Dreval M., Drevlak M., Drewelow P., Drews P., Dunai D., Edlund E., Effenberg F., Ehrke G., Endler M., Ennis D. A., Escoto F. J., Estrada T., Fable E., Fahrenkamp N., Fanni A., Faustin J., Fellinger J., Feng Y., Figacz W., Flom E., Ford O., Fornal T., Frerichs H., Freundt S., Fuchert G., Fukuyama M., Fullenbach F., Gantenbein G., Gao Y., Garcia K., Regana J. M. G., Garcia-Cortes I., Gaspar J., Gates D. A., Geiger J., Geiger B., Giudicotti L., Gonzalez A., Goriaev A., Gradic D., Grahl M., Graves J. P., Green J., Grelier E., Greuner H., Gross S., Grote H., Groth M., Gruca M., Grulke O., Grun M., Arnaiz J. G., Gunter S., Haak V., Haas M., Hacker P., Hakola A., Hallenbert A., Hammond K., Han X., Hansen S. K., Harris J. H., Hartfuss H., Hartmann D., Hathiramani D., Hatzky R., Hawke J., Hegedus S., Hein B., Heinemann B., Helander P., Henneberg S., Hergenhahn U., Hidalgo C., Hindenlang F., Hirsch M., Hofel U., Hollfeld K. P., Holtz A., Hopf D., Hoschen D., Houry M., Howard J., Huang X., Hubeny M., Hudson S., Ida K., Igitkhanov Y., Igochine V., Illy S., Ionita-Schrittwieser C., Isobe M., Jablczynska M., Jablonski S., Jagielski B., Jakubowski M., van Vuuren A. J., Jelonnek J., Jenko F., Jensen T., Jenzsch H., Junghanns P., Kaczmarczyk J., Kallmeyer J., Kamionka U., Kandler M., Kasilov S., Kazakov Y., Kennedy D., Kharwandikar A., Khokhlov M., Kiefer C., Killer C., Kirschner A., Kleiber R., Klinger T., Klose S., Knauer J., Knieps A., Kochl F., Kocsis G., Kolesnichenko Ya. I., Konies A., Konig R., Kontula J., Kornejew P., Koschinsky J., Kozulia M. M., Kramer-Flecken A., Krampitz R., Krause M., Krawczyk N., Kremeyer T., Krier L., Kriete D. M., Krychowiak M., Ksiazek I., Kubkowska M., Kuczynski M., Kuhner G., Kumar A., Kurki-Suonio T., Kwak S., Landreman M., Lang P. T., Langenberg A., Laqua H. P., Laqua H., Laube R., Lazerson S., Lewerentz M., Li C., Liang Y., Linsmeier Ch., Lion J., Litnovsky A., Liu S., Lobsien J., Loizu J., Lore J., Lorenz A., Losada U., Louche F., Lunsford R., Lutsenko V., Machielsen M., Mackel F., Maisano-Brown J., Maj O., Makowski D., Manduchi G., Maragkoudakis E., Marchuk O., Marsen S., Martines E., Martinez-Fernandez J., Marushchenko M., Masuzaki S., Maurer D., Mayer M., McCarthy K. J., McCormack O., McNeely P., Meister H., Mendelevitch B., Mendes S., Merlo A., Messian A., Mielczarek A., Mishchenko O., Missal B., Mitteau R., Moiseenko V. E., Mollen A., Moncada V., Monnich T., Morisaki T., Moseev D., Motojima G., Mulas S., Mulsow M., Nagel M., Naujoks D., Naulin V., Neelis T., Neilson H., Neu R., Neubauer O., Neuner U., Nicolai D., Nielsen S. K., Niemann H., Nishiza T., Nishizawa T., Nuhrenberg C., Ochoukov R., Oelmann J., Offermanns G., Ogawa K., Okamura S., Olmanns J., Ongena J., Oosterbeek J., Otte M., Pablant N., Alvarez N. P., Pandey A., Pasch E., Pavlichenko R., Pavone A., Pawelec E., Pechstein G., Pelka G., Perseo V., Peterson B., Pilopp D., Pingel S., Pisano F., Plockl B., Plunk G., Poloskei P., Pompe B., Popov A., Porkolab M., Proll J., Pueschel M. J., Puiatti M. -E., Sitjes A. P., Purps F., Rahbarnia K., Rasinski M., Rasmussen J., Reiman A., Reimold F., Reisner M., Reiter D., Richou M., Riedl R., Riemann J., Risse K., Roberg-Clark G., Rohde V., Romazanov J., Rondeshagen D., Rong P., Rudischhauser L., Rummel T., Rummel K., Runov A., Rust N., Ryc L., Salembier P., Salewski M., Sanchez E., Satake S., Satheeswaran G., Schacht J., Scharff E., Schauer F., Schilling J., Schlisio G., Schmid K., Schmitt J., Schmitz O., Schneider W., Schneider M., Schneider P., Schrittwieser R., Schroder T., Schroder M., Schroeder R., Schweer B., Schworer D., Scott E., Shanahan B., Sias G., Sichta P., Singer M., Sinha P., Siplia S., Slaby C., Sleczka M., Smith H., Smoniewski J., Sonnendrucker E., Spolaore M., Spring A., Stadler R., Stanczak D., Stange T., Stepanov I., Stephey L., Stober J., Stroth U., Strumberger E., Suzuki C., Suzuki Y., Svensson J., Szabolics T., Szepesi T., Szucs M., Tabares F. L., Tamura N., Tancetti A., Tantos C., Terry J., Thienpondt H., Thomsen H., Thumm M., Travere J. M., Traverso P., Tretter J., Trier E., Mora H. T., Tsujimura T., Turkin Y., Tykhyi A., Unterberg B., van Eeten P., van Milligen B. Ph., van Schoor M., Vano L., Varoutis S., Vecsei M., Vela L., Velasco J. L., Vervier M., Vianello N., Viebke H., Vilbrandt R., Vogel G., Vogt N., Volkhausen C., von Stechow A., Wagner F., Wang E., Wang H., Warmer F., Wauters T., Wegener L., Wegner T., Weir G., Wenzel U., White A., Wilde F., Wilms F., Windisch T., Winkler M., Winter A., Winters V., Wolf R., Wright A. M., Wurden G. A., Xanthopoulos P., Xu S., Yamada H., Yamaguchi H., Yokoyama M., Yoshinuma M., Yu Q., Zamanov M., Zanini M., Zarnstorff M., Zhang D., Zhou S., Zhu J., Zhu C., Zilker M., Zocco A., Zohm H., Zoletnik S., Zsuga L., Pedersen, T, Abramovic, I, Agostinetti, P, Torres, M, Akaslompolo, S, Belloso, J, Aleynikov, P, Aleynikova, K, Alhashimi, M, Ali, A, Allen, N, Alonso, A, Anda, G, Andreeva, T, Angioni, C, Arkhipov, A, Arnold, A, Asad, W, Ascasibar, E, Aumeunier, M, Avramidis, K, Aymerich, E, Baek, S, Bahner, J, Baillod, A, Balden, M, Baldzuhn, J, Ballinger, S, Banduch, M, Bannmann, S, Navarro, A, Barbui, T, Beidler, C, Belafdil, C, Bencze, A, Benndorf, A, Beurskens, M, Biedermann, C, Biletskyi, O, Blackwell, B, Blatzheim, M, Bluhm, T, Bockenhoff, D, Bongiovi, G, Borchardt, M, Borodin, D, Boscary, J, Bosch, H, Bosmann, T, Boswirth, B, Bottger, L, Bottino, A, Bozhenkov, S, Brakel, R, Brandt, C, Brauer, T, Braune, H, Brezinsek, S, Brunner, K, Buller, S, Burhenn, R, Bussiahn, R, Buttenschon, B, Buzas, A, Bykov, V, Calvo, I, Mata, K, Caminal, I, Cannas, B, Cappa, A, Carls, A, Carovani, F, Carr, M, Carralero, D, Carvalho, B, Casas, J, Castano-Bardawil, D, Castejon, F, Chaudhary, N, Chelis, I, Chomiczewska, A, Coenen, J, Cole, M, Cordella, F, Corre, Y, Crombe, K, Cseh, G, Csillag, B, Damm, H, Day, C, de Baar, M, De la Cal, E, Degenkolbe, S, Demby, A, Denk, S, Dhard, C, Di Siena, A, Dinklage, A, Dittmar, T, Dreval, M, Drevlak, M, Drewelow, P, Drews, P, Dunai, D, Edlund, E, Effenberg, F, Ehrke, G, Endler, M, Ennis, D, Escoto, F, Estrada, T, Fable, E, Fahrenkamp, N, Fanni, A, Faustin, J, Fellinger, J, Feng, Y, Figacz, W, Flom, E, Ford, O, Fornal, T, Frerichs, H, Freundt, S, Fuchert, G, Fukuyama, M, Fullenbach, F, Gantenbein, G, Gao, Y, Garcia, K, Regana, J, Garcia-Cortes, I, Gaspar, J, Gates, D, Geiger, J, Geiger, B, Giudicotti, L, Gonzalez, A, Goriaev, A, Gradic, D, Grahl, M, Graves, J, Green, J, Grelier, E, Greuner, H, Gross, S, Grote, H, Groth, M, Gruca, M, Grulke, O, Grun, M, Arnaiz, J, Gunter, S, Haak, V, Haas, M, Hacker, P, Hakola, A, Hallenbert, A, Hammond, K, Han, X, Hansen, S, Harris, J, Hartfuss, H, Hartmann, D, Hathiramani, D, Hatzky, R, Hawke, J, Hegedus, S, Hein, B, Heinemann, B, Helander, P, Henneberg, S, Hergenhahn, U, Hidalgo, C, Hindenlang, F, Hirsch, M, Hofel, U, Hollfeld, K, Holtz, A, Hopf, D, Hoschen, D, Houry, M, Howard, J, Huang, X, Hubeny, M, Hudson, S, Ida, K, Igitkhanov, Y, Igochine, V, Illy, S, Ionita-Schrittwieser, C, Isobe, M, Jablczynska, M, Jablonski, S, Jagielski, B, Jakubowski, M, van Vuuren, A, Jelonnek, J, Jenko, F, Jensen, T, Jenzsch, H, Junghanns, P, Kaczmarczyk, J, Kallmeyer, J, Kamionka, U, Kandler, M, Kasilov, S, Kazakov, Y, Kennedy, D, Kharwandikar, A, Khokhlov, M, Kiefer, C, Killer, C, Kirschner, A, Kleiber, R, Klinger, T, Klose, S, Knauer, J, Knieps, A, Kochl, F, Kocsis, G, Kolesnichenko, Y, Konies, A, Konig, R, Kontula, J, Kornejew, P, Koschinsky, J, Kozulia, M, Kramer-Flecken, A, Krampitz, R, Krause, M, Krawczyk, N, Kremeyer, T, Krier, L, Kriete, D, Krychowiak, M, Ksiazek, I, Kubkowska, M, Kuczynski, M, Kuhner, G, Kumar, A, Kurki-Suonio, T, Kwak, S, Landreman, M, Lang, P, Langenberg, A, Laqua, H, Laube, R, Lazerson, S, Lewerentz, M, Li, C, Liang, Y, Linsmeier, C, Lion, J, Litnovsky, A, Liu, S, Lobsien, J, Loizu, J, Lore, J, Lorenz, A, Losada, U, Louche, F, Lunsford, R, Lutsenko, V, Machielsen, M, Mackel, F, Maisano-Brown, J, Maj, O, Makowski, D, Manduchi, G, Maragkoudakis, E, Marchuk, O, Marsen, S, Martines, E, Martinez-Fernandez, J, Marushchenko, M, Masuzaki, S, Maurer, D, Mayer, M, Mccarthy, K, Mccormack, O, Mcneely, P, Meister, H, Mendelevitch, B, Mendes, S, Merlo, A, Messian, A, Mielczarek, A, Mishchenko, O, Missal, B, Mitteau, R, Moiseenko, V, Mollen, A, Moncada, V, Monnich, T, Morisaki, T, Moseev, D, Motojima, G, Mulas, S, Mulsow, M, Nagel, M, Naujoks, D, Naulin, V, Neelis, T, Neilson, H, Neu, R, Neubauer, O, Neuner, U, Nicolai, D, Nielsen, S, Niemann, H, Nishiza, T, Nishizawa, T, Nuhrenberg, C, Ochoukov, R, Oelmann, J, Offermanns, G, Ogawa, K, Okamura, S, Olmanns, J, Ongena, J, Oosterbeek, J, Otte, M, Pablant, N, Alvarez, N, Pandey, A, Pasch, E, Pavlichenko, R, Pavone, A, Pawelec, E, Pechstein, G, Pelka, G, Perseo, V, Peterson, B, Pilopp, D, Pingel, S, Pisano, F, Plockl, B, Plunk, G, Poloskei, P, Pompe, B, Popov, A, Porkolab, M, Proll, J, Pueschel, M, Puiatti, M, Sitjes, A, Purps, F, Rahbarnia, K, Rasinski, M, Rasmussen, J, Reiman, A, Reimold, F, Reisner, M, Reiter, D, Richou, M, Riedl, R, Riemann, J, Risse, K, Roberg-Clark, G, Rohde, V, Romazanov, J, Rondeshagen, D, Rong, P, Rudischhauser, L, Rummel, T, Rummel, K, Runov, A, Rust, N, Ryc, L, Salembier, P, Salewski, M, Sanchez, E, Satake, S, Satheeswaran, G, Schacht, J, Scharff, E, Schauer, F, Schilling, J, Schlisio, G, Schmid, K, Schmitt, J, Schmitz, O, Schneider, W, Schneider, M, Schneider, P, Schrittwieser, R, Schroder, T, Schroder, M, Schroeder, R, Schweer, B, Schworer, D, Scott, E, Shanahan, B, Sias, G, Sichta, P, Singer, M, Sinha, P, Siplia, S, Slaby, C, Sleczka, M, Smith, H, Smoniewski, J, Sonnendrucker, E, Spolaore, M, Spring, A, Stadler, R, Stanczak, D, Stange, T, Stepanov, I, Stephey, L, Stober, J, Stroth, U, Strumberger, E, Suzuki, C, Suzuki, Y, Svensson, J, Szabolics, T, Szepesi, T, Szucs, M, Tabares, F, Tamura, N, Tancetti, A, Tantos, C, Terry, J, Thienpondt, H, Thomsen, H, Thumm, M, Travere, J, Traverso, P, Tretter, J, Trier, E, Mora, H, Tsujimura, T, Turkin, Y, Tykhyi, A, Unterberg, B, van Eeten, P, van Milligen, B, van Schoor, M, Vano, L, Varoutis, S, Vecsei, M, Vela, L, Velasco, J, Vervier, M, Vianello, N, Viebke, H, Vilbrandt, R, Vogel, G, Vogt, N, Volkhausen, C, von Stechow, A, Wagner, F, Wang, E, Wang, H, Warmer, F, Wauters, T, Wegener, L, Wegner, T, Weir, G, Wenzel, U, White, A, Wilde, F, Wilms, F, Windisch, T, Winkler, M, Winter, A, Winters, V, Wolf, R, Wright, A, Wurden, G, Xanthopoulos, P, Xu, S, Yamada, H, Yamaguchi, H, Yokoyama, M, Yoshinuma, M, Yu, Q, Zamanov, M, Zanini, M, Zarnstorff, M, Zhang, D, Zhou, S, Zhu, J, Zhu, C, Zilker, M, Zocco, A, Zohm, H, Zoletnik, S, Zsuga, L, Pedersen T. S., Abramovic I., Agostinetti P., Torres M. A., Akaslompolo S., Belloso J. A., Aleynikov P., Aleynikova K., Alhashimi M., Ali A., Allen N., Alonso A., Anda G., Andreeva T., Angioni C., Arkhipov A., Arnold A., Asad W., Ascasibar E., Aumeunier M. -H., Avramidis K., Aymerich E., Baek S. -G., Bahner J., Baillod A., Balden M., Baldzuhn J., Ballinger S., Banduch M., Bannmann S., Navarro A. B., Barbui T., Beidler C., Belafdil C., Bencze A., Benndorf A., Beurskens M., Biedermann C., Biletskyi O., Blackwell B., Blatzheim M., Bluhm T., Bockenhoff D., Bongiovi G., Borchardt M., Borodin D., Boscary J., Bosch H., Bosmann T., Boswirth B., Bottger L., Bottino A., Bozhenkov S., Brakel R., Brandt C., Brauer T., Braune H., Brezinsek S., Brunner K., Buller S., Burhenn R., Bussiahn R., Buttenschon B., Buzas A., Bykov V., Calvo I., Mata K. C., Caminal I., Cannas B., Cappa A., Carls A., Carovani F., Carr M., Carralero D., Carvalho B., Casas J., Castano-Bardawil D., Castejon F., Chaudhary N., Chelis I., Chomiczewska A., Coenen J. W., Cole M., Cordella F., Corre Y., Crombe K., Cseh G., Csillag B., Damm H., Day C., de Baar M., De la Cal E., Degenkolbe S., Demby A., Denk S., Dhard C., Di Siena A., Dinklage A., Dittmar T., Dreval M., Drevlak M., Drewelow P., Drews P., Dunai D., Edlund E., Effenberg F., Ehrke G., Endler M., Ennis D. A., Escoto F. J., Estrada T., Fable E., Fahrenkamp N., Fanni A., Faustin J., Fellinger J., Feng Y., Figacz W., Flom E., Ford O., Fornal T., Frerichs H., Freundt S., Fuchert G., Fukuyama M., Fullenbach F., Gantenbein G., Gao Y., Garcia K., Regana J. M. G., Garcia-Cortes I., Gaspar J., Gates D. A., Geiger J., Geiger B., Giudicotti L., Gonzalez A., Goriaev A., Gradic D., Grahl M., Graves J. P., Green J., Grelier E., Greuner H., Gross S., Grote H., Groth M., Gruca M., Grulke O., Grun M., Arnaiz J. G., Gunter S., Haak V., Haas M., Hacker P., Hakola A., Hallenbert A., Hammond K., Han X., Hansen S. K., Harris J. H., Hartfuss H., Hartmann D., Hathiramani D., Hatzky R., Hawke J., Hegedus S., Hein B., Heinemann B., Helander P., Henneberg S., Hergenhahn U., Hidalgo C., Hindenlang F., Hirsch M., Hofel U., Hollfeld K. P., Holtz A., Hopf D., Hoschen D., Houry M., Howard J., Huang X., Hubeny M., Hudson S., Ida K., Igitkhanov Y., Igochine V., Illy S., Ionita-Schrittwieser C., Isobe M., Jablczynska M., Jablonski S., Jagielski B., Jakubowski M., van Vuuren A. J., Jelonnek J., Jenko F., Jensen T., Jenzsch H., Junghanns P., Kaczmarczyk J., Kallmeyer J., Kamionka U., Kandler M., Kasilov S., Kazakov Y., Kennedy D., Kharwandikar A., Khokhlov M., Kiefer C., Killer C., Kirschner A., Kleiber R., Klinger T., Klose S., Knauer J., Knieps A., Kochl F., Kocsis G., Kolesnichenko Ya. I., Konies A., Konig R., Kontula J., Kornejew P., Koschinsky J., Kozulia M. M., Kramer-Flecken A., Krampitz R., Krause M., Krawczyk N., Kremeyer T., Krier L., Kriete D. M., Krychowiak M., Ksiazek I., Kubkowska M., Kuczynski M., Kuhner G., Kumar A., Kurki-Suonio T., Kwak S., Landreman M., Lang P. T., Langenberg A., Laqua H. P., Laqua H., Laube R., Lazerson S., Lewerentz M., Li C., Liang Y., Linsmeier Ch., Lion J., Litnovsky A., Liu S., Lobsien J., Loizu J., Lore J., Lorenz A., Losada U., Louche F., Lunsford R., Lutsenko V., Machielsen M., Mackel F., Maisano-Brown J., Maj O., Makowski D., Manduchi G., Maragkoudakis E., Marchuk O., Marsen S., Martines E., Martinez-Fernandez J., Marushchenko M., Masuzaki S., Maurer D., Mayer M., McCarthy K. J., McCormack O., McNeely P., Meister H., Mendelevitch B., Mendes S., Merlo A., Messian A., Mielczarek A., Mishchenko O., Missal B., Mitteau R., Moiseenko V. E., Mollen A., Moncada V., Monnich T., Morisaki T., Moseev D., Motojima G., Mulas S., Mulsow M., Nagel M., Naujoks D., Naulin V., Neelis T., Neilson H., Neu R., Neubauer O., Neuner U., Nicolai D., Nielsen S. K., Niemann H., Nishiza T., Nishizawa T., Nuhrenberg C., Ochoukov R., Oelmann J., Offermanns G., Ogawa K., Okamura S., Olmanns J., Ongena J., Oosterbeek J., Otte M., Pablant N., Alvarez N. P., Pandey A., Pasch E., Pavlichenko R., Pavone A., Pawelec E., Pechstein G., Pelka G., Perseo V., Peterson B., Pilopp D., Pingel S., Pisano F., Plockl B., Plunk G., Poloskei P., Pompe B., Popov A., Porkolab M., Proll J., Pueschel M. J., Puiatti M. -E., Sitjes A. P., Purps F., Rahbarnia K., Rasinski M., Rasmussen J., Reiman A., Reimold F., Reisner M., Reiter D., Richou M., Riedl R., Riemann J., Risse K., Roberg-Clark G., Rohde V., Romazanov J., Rondeshagen D., Rong P., Rudischhauser L., Rummel T., Rummel K., Runov A., Rust N., Ryc L., Salembier P., Salewski M., Sanchez E., Satake S., Satheeswaran G., Schacht J., Scharff E., Schauer F., Schilling J., Schlisio G., Schmid K., Schmitt J., Schmitz O., Schneider W., Schneider M., Schneider P., Schrittwieser R., Schroder T., Schroder M., Schroeder R., Schweer B., Schworer D., Scott E., Shanahan B., Sias G., Sichta P., Singer M., Sinha P., Siplia S., Slaby C., Sleczka M., Smith H., Smoniewski J., Sonnendrucker E., Spolaore M., Spring A., Stadler R., Stanczak D., Stange T., Stepanov I., Stephey L., Stober J., Stroth U., Strumberger E., Suzuki C., Suzuki Y., Svensson J., Szabolics T., Szepesi T., Szucs M., Tabares F. L., Tamura N., Tancetti A., Tantos C., Terry J., Thienpondt H., Thomsen H., Thumm M., Travere J. M., Traverso P., Tretter J., Trier E., Mora H. T., Tsujimura T., Turkin Y., Tykhyi A., Unterberg B., van Eeten P., van Milligen B. Ph., van Schoor M., Vano L., Varoutis S., Vecsei M., Vela L., Velasco J. L., Vervier M., Vianello N., Viebke H., Vilbrandt R., Vogel G., Vogt N., Volkhausen C., von Stechow A., Wagner F., Wang E., Wang H., Warmer F., Wauters T., Wegener L., Wegner T., Weir G., Wenzel U., White A., Wilde F., Wilms F., Windisch T., Winkler M., Winter A., Winters V., Wolf R., Wright A. M., Wurden G. A., Xanthopoulos P., Xu S., Yamada H., Yamaguchi H., Yokoyama M., Yoshinuma M., Yu Q., Zamanov M., Zanini M., Zarnstorff M., Zhang D., Zhou S., Zhu J., Zhu C., Zilker M., Zocco A., Zohm H., Zoletnik S., and Zsuga L.

Abstract

We present recent highlights from the most recent operation phases of Wendelstein 7-X, the most advanced stellarator in the world. Stable detachment with good particle exhaust, low impurity content, and energy confinement times exceeding 100 ms, have been maintained for tens of seconds. Pellet fueling allows for plasma phases with reduced ion-temperature-gradient turbulence, and during such phases, the overall confinement is so good (energy confinement times often exceeding 200 ms) that the attained density and temperature profiles would not have been possible in less optimized devices, since they would have had neoclassical transport losses exceeding the heating applied in W7-X. This provides proof that the reduction of neoclassical transport through magnetic field optimization is successful. W7-X plasmas generally show good impurity screening and high plasma purity, but there is evidence of longer impurity confinement times during turbulence-suppressed phases.

Published
2022

21. Supplemental Material, sj-doc-1-jgp-10.1177_0891988720964250 - Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

Author

Santos-García, Diego, Castro, E. Suárez, de Deus Fonticoba, T., Panceiras, M. J. Feal, Enriquez, J. G. Muñoz, González, J. M. Paz, Bartolomé, C. Cores, Planellas, L. L., Caldentey, J. García, Caballol, N., Legarda, I., López, I. Cabo, Manzanares, L. López, Rivera, M. A. Ávila, Catalán, M. J., Nogueira, V., Borrué, C., Sauco, M. Álvarez, Vela, L., Cubo, E., Castrillo, J. C. Martínez, Alonso, P. Sánchez, Losada, M. G. Alonso, Ariztegui, N. López, Gastón, M. I., Kulisevsky, J., Pagonabarraga, J., Seijo, M., Martínez, J. Ruíz, Valero, C., Kurtis, M., Ardura, J. González, Prieto, C., Mir, P., and Martinez-Martin, P.

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material, sj-doc-1-jgp-10.1177_0891988720964250 for Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease by Diego Santos-García, E. Suárez Castro, T. de Deus Fonticoba, M. J. Feal Panceiras, J. G. Muñoz Enriquez, J. M. Paz González, C. Cores Bartolomé, L. L. Planellas, J. García Caldentey, N. Caballol, I. Legarda, I. Cabo López, L. López Manzanares, M. A. Ávila Rivera, M. J. Catalán, V. Nogueira, C. Borrué, M. Álvarez Sauco, L. Vela, E. Cubo, J. C. Martínez Castrillo, P. Sánchez Alonso, M. G. Alonso Losada, N. López Ariztegui, M. I. Gastón, J. Kulisevsky, J. Pagonabarraga, M. Seijo, J. Ruíz Martínez, C. Valero, M. Kurtis, J. González Ardura, C. Prieto, P. Mir, P. Martinez-Martin and on behalf of the COPPADIS Study Group in Journal of Geriatric Psychiatry and Neurology

Published
2023
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22. Supplemental Material, sj-pdf-2-jgp-10.1177_0891988720964250 - Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

Author

Santos-García, Diego, Castro, E. Suárez, de Deus Fonticoba, T., Panceiras, M. J. Feal, Enriquez, J. G. Muñoz, González, J. M. Paz, Bartolomé, C. Cores, Planellas, L. L., Caldentey, J. García, Caballol, N., Legarda, I., López, I. Cabo, Manzanares, L. López, Rivera, M. A. Ávila, Catalán, M. J., Nogueira, V., Borrué, C., Sauco, M. Álvarez, Vela, L., Cubo, E., Castrillo, J. C. Martínez, Alonso, P. Sánchez, Losada, M. G. Alonso, Ariztegui, N. López, Gastón, M. I., Kulisevsky, J., Pagonabarraga, J., Seijo, M., Martínez, J. Ruíz, Valero, C., Kurtis, M., Ardura, J. González, Prieto, C., Mir, P., and Martinez-Martin, P.

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material, sj-pdf-2-jgp-10.1177_0891988720964250 for Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease by Diego Santos-García, E. Suárez Castro, T. de Deus Fonticoba, M. J. Feal Panceiras, J. G. Muñoz Enriquez, J. M. Paz González, C. Cores Bartolomé, L. L. Planellas, J. García Caldentey, N. Caballol, I. Legarda, I. Cabo López, L. López Manzanares, M. A. Ávila Rivera, M. J. Catalán, V. Nogueira, C. Borrué, M. Álvarez Sauco, L. Vela, E. Cubo, J. C. Martínez Castrillo, P. Sánchez Alonso, M. G. Alonso Losada, N. López Ariztegui, M. I. Gastón, J. Kulisevsky, J. Pagonabarraga, M. Seijo, J. Ruíz Martínez, C. Valero, M. Kurtis, J. González Ardura, C. Prieto, P. Mir, P. Martinez-Martin and on behalf of the COPPADIS Study Group in Journal of Geriatric Psychiatry and Neurology

Published
2023
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23. Supplemental Material, sj-pdf-1-jgp-10.1177_0891988720964250 - Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

Author

Santos-García, Diego, Castro, E. Suárez, de Deus Fonticoba, T., Panceiras, M. J. Feal, Enriquez, J. G. Muñoz, González, J. M. Paz, Bartolomé, C. Cores, Planellas, L. L., Caldentey, J. García, Caballol, N., Legarda, I., López, I. Cabo, Manzanares, L. López, Rivera, M. A. Ávila, Catalán, M. J., Nogueira, V., Borrué, C., Sauco, M. Álvarez, Vela, L., Cubo, E., Castrillo, J. C. Martínez, Alonso, P. Sánchez, Losada, M. G. Alonso, Ariztegui, N. López, Gastón, M. I., Kulisevsky, J., Pagonabarraga, J., Seijo, M., Martínez, J. Ruíz, Valero, C., Kurtis, M., Ardura, J. González, Prieto, C., Mir, P., and Martinez-Martin, P.

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material, sj-pdf-1-jgp-10.1177_0891988720964250 for Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease by Diego Santos-García, E. Suárez Castro, T. de Deus Fonticoba, M. J. Feal Panceiras, J. G. Muñoz Enriquez, J. M. Paz González, C. Cores Bartolomé, L. L. Planellas, J. García Caldentey, N. Caballol, I. Legarda, I. Cabo López, L. López Manzanares, M. A. Ávila Rivera, M. J. Catalán, V. Nogueira, C. Borrué, M. Álvarez Sauco, L. Vela, E. Cubo, J. C. Martínez Castrillo, P. Sánchez Alonso, M. G. Alonso Losada, N. López Ariztegui, M. I. Gastón, J. Kulisevsky, J. Pagonabarraga, M. Seijo, J. Ruíz Martínez, C. Valero, M. Kurtis, J. González Ardura, C. Prieto, P. Mir, P. Martinez-Martin and on behalf of the COPPADIS Study Group in Journal of Geriatric Psychiatry and Neurology

Published
2023
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25. 20604. LA CLASIFICACIÓN MNCD CORRELACIONA MEJOR CON LA CALIDAD DE VIDA Y SITUACIÓN FUNCIONAL EN LOS PACIENTES CON ENFERMEDAD DE PARKINSON QUE EL HOEHN Y YAHR

Author

Gallego González, L., Santos García, D., de Deus Fonticoba, T., Jesús Maestre, S., Cosgaya, M., García Caldentey, J., Caballol Pons, N., Legarda, I., Hernández Vara, J., Cabo, I., López Manzanares, L., González Aramburu, I., Ávila Rivera, M., Gómez Mayordomo, V., Nogueira Fernández, V., García Soto, J., Borrué Fernández, C., Solano Vila, B., Álvarez Sauco, M., Vela, L., Escalante, S., Cubo, E., Mendoza, Z., Pareés, I., Sánchez Alonso, P., Alonso Losada, M., López Ariztegui, N., Gastón, I., Kulisevsky, J., Seijo Martínez, M., Valero Merino, C., Alonso Redondo, R., Ordás, C., Menéndez González, M., Martínez Martín, P., and Mir Rivera, P.

Published
2024
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26. Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X

Author

Pedersen, Thomas Sunn, Abramovic, I., Agostinetti, P., Torres, M. Agredano, Äkäslompolo, S., Belloso, J. Alcuson, Aleynikov, P., Aleynikova, K., Alhashimi, M., Ali, A., Allen, N., Alonso, A., Anda, G., Andreeva, T., Angioni, C., Arkhipov, A., Arnold, A., Asad, W., Ascasibar, E., Aumeunier, M. H., Avramidis, K., Aymerich, E., Baek, S. G., Bähner, J., Baillod, A., Balden, M., Baldzuhn, J., Ballinger, S., Banduch, M., Bannmann, S., Navarro, A. Bañón, Barbui, T., Beidler, C., Belafdil, C., Bencze, A., Benndorf, A., Beurskens, M., Biedermann, C., Biletskyi, O., Blackwell, B., Blatzheim, M., Bluhm, T., Böckenhoff, D., Bongiovi, G., Borchardt, M., Borodin, D., Boscary, J., Bosch, H., Bosmann, T., Böswirth, B., Böttger, L., Bottino, A., Bozhenkov, S., Brakel, R., Brandt, C., Bräuer, T., Braune, H., Brezinsek, S., Brunner, K., Buller, S., Burhenn, R., Bussiahn, R., Buttenschön, B., Buzás, A., Bykov, V., Calvo, I., Mata, K. Camacho, Caminal, I., Cannas, B., Cappa, A., Carls, A., Carovani, F., Carr, M., Carralero, D., Carvalho, B., Casas, J., Castano-Bardawil, D., Castejon, F., Chaudhary, N., Chelis, I., Chomiczewska, A., Coenen, J. W., Cole, M., Cordella, F., Corre, Y., Crombe, K., Cseh, G., Csillag, B., Damm, H., Day, C., de Baar, M., De la Cal, E., Degenkolbe, S., Demby, A., Denk, S., Dhard, C., Di Siena, A., Dinklage, A., Dittmar, T., Dreval, M., Drevlak, M., Drewelow, P., Drews, P., Dunai, D., Edlund, E., Effenberg, F., Ehrke, G., Endler, M., Ennis, D. A., Escoto, F. J., Estrada, T., Fable, E., Fahrenkamp, N., Fanni, A., Faustin, J., Fellinger, J., Feng, Y., Figacz, W., Flom, E., Ford, O., Fornal, T., Frerichs, H., Freundt, S., Fuchert, G., Fukuyama, M., Füllenbach, F., Gantenbein, G., Gao, Y., Garcia, K., Regaña, J. M.García, García-Cortés, I., Gaspar, J., Gates, D. A., Geiger, J., Geiger, B., Giudicotti, L., González, A., Goriaev, A., Gradic, D., Grahl, M., Graves, J. P., Green, J., Grelier, E., Greuner, H., Groß, S., Grote, H., Groth, M., Gruca, M., Grulke, O., Grün, M., Arnaiz, J. Guerrero, Günter, S., Haak, V., Haas, M., Hacker, P., Hakola, A., Hallenbert, A., Hammond, K., Han, X., Hansen, S. K., Harris, J. H., Hartfuß, H., Hartmann, D., Hathiramani, D., Hatzky, R., Hawke, J., Hegedus, S., Hein, B., Heinemann, B., Helander, P., Henneberg, S., Hergenhahn, U., Hidalgo, C., Hindenlang, F., Hirsch, M., Höfel, U., Hollfeld, K. P., Holtz, A., Hopf, D., Höschen, D., Houry, M., Howard, J., Huang, X., Hubeny, M., Hudson, S., Ida, K., Igitkhanov, Y., Igochine, V., Illy, S., Ionita-Schrittwieser, C., Isobe, M., Jabłczynska, M., Jablonski, S., Jagielski, B., Jakubowski, M., van Vuuren, A. Jansen, Jelonnek, J., Jenko, F., Jensen, T., Jenzsch, H., Junghanns, P., Kaczmarczyk, J., Kallmeyer, J., Kamionka, U., Kandler, M., Kasilov, S., Kazakov, Y., Kennedy, D., Kharwandikar, A., Khokhlov, M., Kiefer, C., Killer, C., Kirschner, A., Kleiber, R., Klinger, T., Klose, S., Knauer, J., Knieps, A., Köchl, F., Kocsis, G., Kolesnichenko, Ya I., Könies, A., König, R., Kontula, J., Kornejew, P., Koschinsky, J., Kozulia, M. M., Krämer-Flecken, A., Krampitz, R., Krause, M., Krawczyk, N., Kremeyer, T., Krier, L., Kriete, D. M., Krychowiak, M., Ksiazek, I., Kubkowska, M., Kuczynski, M., Kühner, G., Kumar, A., Kurki-Suonio, T., Kwak, S., Landreman, M., Lang, P. T., Langenberg, A., Laqua, H., Laube, R., Lazerson, S., Lewerentz, M., Li, C., Liang, Y., Linsmeier, Ch, Lion, J., Litnovsky, A., Liu, S., Lobsien, J., Loizu, J., Lore, J., Lorenz, A., Losada, U., Louche, F., Lunsford, R., Lutsenko, V., Machielsen, M., Mackel, F., Maisano-Brown, J., Maj, O., Makowski, D., Manduchi, G., Maragkoudakis, E., Marchuk, O., Marsen, S., Martines, E., Martinez-Fernandez, J., Marushchenko, M., Masuzaki, S., Maurer, D., Mayer, M., McCarthy, K. J., McCormack, O., McNeely, P., Meister, H., Mendelevitch, B., Mendes, S., Merlo, A., Messian, A., Mielczarek, A., Mishchenko, O., Missal, B., Mitteau, R., Moiseenko, V. E., Mollen, A., Moncada, V., Mönnich, T., Morisaki, T., Moseev, D., Motojima, G., Mulas, S., Mulsow, M., Nagel, M., Naujoks, D., Naulin, V., Neelis, T., Neilson, H., Neu, R., Neubauer, O., Neuner, U., Nicolai, D., Nielsen, S. K., Niemann, H., Nishiza, T., Nishizawa, T., Nührenberg, C., Ochoukov, R., Oelmann, J., Offermanns, G., Ogawa, K., Okamura, S., Ölmanns, J., Ongena, J., Oosterbeek, J., Otte, M., Pablant, N., Alvarez, N. Panadero, Pandey, A., Pasch, E., Pavlichenko, R., Pavone, A., Pawelec, E., Pechstein, G., Pelka, G., Perseo, V., Peterson, B., Pilopp, D., Pingel, S., Pisano, F., Plöckl, B., Plunk, G., Pölöskei, P., Pompe, B., Popov, A., Porkolab, M., Proll, J., Pueschel, M. J., Puiatti, M. E., Sitjes, A. Puig, Purps, F., Rahbarnia, K., Rasinski, M., Rasmussen, J., Reiman, A., Reimold, F., Reisner, M., Reiter, D., Richou, M., Riedl, R., Riemann, J., Riße, K., Roberg-Clark, G., Rohde, V., Romazanov, J., Rondeshagen, D., Rong, P., Rudischhauser, L., Rummel, T., Rummel, K., Runov, A., Rust, N., Ryc, L., Salembier, P., Salewski, M., Sanchez, E., Satake, S., Satheeswaran, G., Schacht, J., Scharff, E., Schauer, F., Schilling, J., Schlisio, G., Schmid, K., Schmitt, J., Schmitz, O., Schneider, W., Schneider, M., Schneider, P., Schrittwieser, R., Schröder, T., Schröder, M., Schroeder, R., Schweer, B., Schwörer, D., Scott, E., Shanahan, B., Sias, G., Sichta, P., Singer, M., Sinha, P., Sipliä, S., Slaby, C., Sleczka, M., Smith, H., Smoniewski, J., Sonnendrücker, E., Spolaore, M., Spring, A., Stadler, R., Stanczak, D., Stange, T., Stepanov, I., Stephey, L., Stober, J., Stroth, U., Strumberger, E., Suzuki, C., Suzuki, Y., Svensson, J., Szabolics, T., Szepesi, T., Szücs, M., Tabarés, F. L., Tamura, N., Tancetti, A., Tantos, C., Terry, J., Thienpondt, H., Thomsen, H., Thumm, M., Travere, J. M., Traverso, P., Tretter, J., Trier, E., Mora, H. Trimino, Tsujimura, T., Turkin, Y., Tykhyi, A., Unterberg, B., van Eeten, P., van Milligen, B. Ph, van Schoor, M., Vano, L., Varoutis, S., Vecsei, M., Vela, L., Velasco, J. L., Vervier, M., Vianello, N., Viebke, H., Vilbrandt, R., Vogel, G., Vogt, N., Volkhausen, C., von Stechow, A., Wagner, F., Wang, E., Wang, H., Warmer, F., Wauters, T., Wegener, L., Wegner, T., Weir, G., Wenzel, U., White, A., Wilde, F., Wilms, F., Windisch, T., Winkler, M., Winter, A., Winters, V., Wolf, R., Wright, A. M., Wurden, G. A., Xanthopoulos, P., Xu, S., Yamada, H., Yamaguchi, H., Yokoyama, M., Yoshinuma, M., Yu, Q., Zamanov, M., Zanini, M., Zarnstorff, M., Zhang, D., Zhou, S., Zhu, J., Zhu, C., Zilker, M., Zocco, A., Zohm, H., Zoletnik, S., Zsuga, L., Pedersen, Thomas Sunn, Abramovic, I., Agostinetti, P., Torres, M. Agredano, Äkäslompolo, S., Belloso, J. Alcuson, Aleynikov, P., Aleynikova, K., Alhashimi, M., Ali, A., Allen, N., Alonso, A., Anda, G., Andreeva, T., Angioni, C., Arkhipov, A., Arnold, A., Asad, W., Ascasibar, E., Aumeunier, M. H., Avramidis, K., Aymerich, E., Baek, S. G., Bähner, J., Baillod, A., Balden, M., Baldzuhn, J., Ballinger, S., Banduch, M., Bannmann, S., Navarro, A. Bañón, Barbui, T., Beidler, C., Belafdil, C., Bencze, A., Benndorf, A., Beurskens, M., Biedermann, C., Biletskyi, O., Blackwell, B., Blatzheim, M., Bluhm, T., Böckenhoff, D., Bongiovi, G., Borchardt, M., Borodin, D., Boscary, J., Bosch, H., Bosmann, T., Böswirth, B., Böttger, L., Bottino, A., Bozhenkov, S., Brakel, R., Brandt, C., Bräuer, T., Braune, H., Brezinsek, S., Brunner, K., Buller, S., Burhenn, R., Bussiahn, R., Buttenschön, B., Buzás, A., Bykov, V., Calvo, I., Mata, K. Camacho, Caminal, I., Cannas, B., Cappa, A., Carls, A., Carovani, F., Carr, M., Carralero, D., Carvalho, B., Casas, J., Castano-Bardawil, D., Castejon, F., Chaudhary, N., Chelis, I., Chomiczewska, A., Coenen, J. W., Cole, M., Cordella, F., Corre, Y., Crombe, K., Cseh, G., Csillag, B., Damm, H., Day, C., de Baar, M., De la Cal, E., Degenkolbe, S., Demby, A., Denk, S., Dhard, C., Di Siena, A., Dinklage, A., Dittmar, T., Dreval, M., Drevlak, M., Drewelow, P., Drews, P., Dunai, D., Edlund, E., Effenberg, F., Ehrke, G., Endler, M., Ennis, D. A., Escoto, F. J., Estrada, T., Fable, E., Fahrenkamp, N., Fanni, A., Faustin, J., Fellinger, J., Feng, Y., Figacz, W., Flom, E., Ford, O., Fornal, T., Frerichs, H., Freundt, S., Fuchert, G., Fukuyama, M., Füllenbach, F., Gantenbein, G., Gao, Y., Garcia, K., Regaña, J. M.García, García-Cortés, I., Gaspar, J., Gates, D. A., Geiger, J., Geiger, B., Giudicotti, L., González, A., Goriaev, A., Gradic, D., Grahl, M., Graves, J. P., Green, J., Grelier, E., Greuner, H., Groß, S., Grote, H., Groth, M., Gruca, M., Grulke, O., Grün, M., Arnaiz, J. Guerrero, Günter, S., Haak, V., Haas, M., Hacker, P., Hakola, A., Hallenbert, A., Hammond, K., Han, X., Hansen, S. K., Harris, J. H., Hartfuß, H., Hartmann, D., Hathiramani, D., Hatzky, R., Hawke, J., Hegedus, S., Hein, B., Heinemann, B., Helander, P., Henneberg, S., Hergenhahn, U., Hidalgo, C., Hindenlang, F., Hirsch, M., Höfel, U., Hollfeld, K. P., Holtz, A., Hopf, D., Höschen, D., Houry, M., Howard, J., Huang, X., Hubeny, M., Hudson, S., Ida, K., Igitkhanov, Y., Igochine, V., Illy, S., Ionita-Schrittwieser, C., Isobe, M., Jabłczynska, M., Jablonski, S., Jagielski, B., Jakubowski, M., van Vuuren, A. Jansen, Jelonnek, J., Jenko, F., Jensen, T., Jenzsch, H., Junghanns, P., Kaczmarczyk, J., Kallmeyer, J., Kamionka, U., Kandler, M., Kasilov, S., Kazakov, Y., Kennedy, D., Kharwandikar, A., Khokhlov, M., Kiefer, C., Killer, C., Kirschner, A., Kleiber, R., Klinger, T., Klose, S., Knauer, J., Knieps, A., Köchl, F., Kocsis, G., Kolesnichenko, Ya I., Könies, A., König, R., Kontula, J., Kornejew, P., Koschinsky, J., Kozulia, M. M., Krämer-Flecken, A., Krampitz, R., Krause, M., Krawczyk, N., Kremeyer, T., Krier, L., Kriete, D. M., Krychowiak, M., Ksiazek, I., Kubkowska, M., Kuczynski, M., Kühner, G., Kumar, A., Kurki-Suonio, T., Kwak, S., Landreman, M., Lang, P. T., Langenberg, A., Laqua, H., Laube, R., Lazerson, S., Lewerentz, M., Li, C., Liang, Y., Linsmeier, Ch, Lion, J., Litnovsky, A., Liu, S., Lobsien, J., Loizu, J., Lore, J., Lorenz, A., Losada, U., Louche, F., Lunsford, R., Lutsenko, V., Machielsen, M., Mackel, F., Maisano-Brown, J., Maj, O., Makowski, D., Manduchi, G., Maragkoudakis, E., Marchuk, O., Marsen, S., Martines, E., Martinez-Fernandez, J., Marushchenko, M., Masuzaki, S., Maurer, D., Mayer, M., McCarthy, K. J., McCormack, O., McNeely, P., Meister, H., Mendelevitch, B., Mendes, S., Merlo, A., Messian, A., Mielczarek, A., Mishchenko, O., Missal, B., Mitteau, R., Moiseenko, V. E., Mollen, A., Moncada, V., Mönnich, T., Morisaki, T., Moseev, D., Motojima, G., Mulas, S., Mulsow, M., Nagel, M., Naujoks, D., Naulin, V., Neelis, T., Neilson, H., Neu, R., Neubauer, O., Neuner, U., Nicolai, D., Nielsen, S. K., Niemann, H., Nishiza, T., Nishizawa, T., Nührenberg, C., Ochoukov, R., Oelmann, J., Offermanns, G., Ogawa, K., Okamura, S., Ölmanns, J., Ongena, J., Oosterbeek, J., Otte, M., Pablant, N., Alvarez, N. Panadero, Pandey, A., Pasch, E., Pavlichenko, R., Pavone, A., Pawelec, E., Pechstein, G., Pelka, G., Perseo, V., Peterson, B., Pilopp, D., Pingel, S., Pisano, F., Plöckl, B., Plunk, G., Pölöskei, P., Pompe, B., Popov, A., Porkolab, M., Proll, J., Pueschel, M. J., Puiatti, M. E., Sitjes, A. Puig, Purps, F., Rahbarnia, K., Rasinski, M., Rasmussen, J., Reiman, A., Reimold, F., Reisner, M., Reiter, D., Richou, M., Riedl, R., Riemann, J., Riße, K., Roberg-Clark, G., Rohde, V., Romazanov, J., Rondeshagen, D., Rong, P., Rudischhauser, L., Rummel, T., Rummel, K., Runov, A., Rust, N., Ryc, L., Salembier, P., Salewski, M., Sanchez, E., Satake, S., Satheeswaran, G., Schacht, J., Scharff, E., Schauer, F., Schilling, J., Schlisio, G., Schmid, K., Schmitt, J., Schmitz, O., Schneider, W., Schneider, M., Schneider, P., Schrittwieser, R., Schröder, T., Schröder, M., Schroeder, R., Schweer, B., Schwörer, D., Scott, E., Shanahan, B., Sias, G., Sichta, P., Singer, M., Sinha, P., Sipliä, S., Slaby, C., Sleczka, M., Smith, H., Smoniewski, J., Sonnendrücker, E., Spolaore, M., Spring, A., Stadler, R., Stanczak, D., Stange, T., Stepanov, I., Stephey, L., Stober, J., Stroth, U., Strumberger, E., Suzuki, C., Suzuki, Y., Svensson, J., Szabolics, T., Szepesi, T., Szücs, M., Tabarés, F. L., Tamura, N., Tancetti, A., Tantos, C., Terry, J., Thienpondt, H., Thomsen, H., Thumm, M., Travere, J. M., Traverso, P., Tretter, J., Trier, E., Mora, H. Trimino, Tsujimura, T., Turkin, Y., Tykhyi, A., Unterberg, B., van Eeten, P., van Milligen, B. Ph, van Schoor, M., Vano, L., Varoutis, S., Vecsei, M., Vela, L., Velasco, J. L., Vervier, M., Vianello, N., Viebke, H., Vilbrandt, R., Vogel, G., Vogt, N., Volkhausen, C., von Stechow, A., Wagner, F., Wang, E., Wang, H., Warmer, F., Wauters, T., Wegener, L., Wegner, T., Weir, G., Wenzel, U., White, A., Wilde, F., Wilms, F., Windisch, T., Winkler, M., Winter, A., Winters, V., Wolf, R., Wright, A. M., Wurden, G. A., Xanthopoulos, P., Xu, S., Yamada, H., Yamaguchi, H., Yokoyama, M., Yoshinuma, M., Yu, Q., Zamanov, M., Zanini, M., Zarnstorff, M., Zhang, D., Zhou, S., Zhu, J., Zhu, C., Zilker, M., Zocco, A., Zohm, H., Zoletnik, S., and Zsuga, L.

Abstract

We present recent highlights from the most recent operation phases of Wendelstein 7-X, the most advanced stellarator in the world. Stable detachment with good particle exhaust, low impurity content, and energy confinement times exceeding 100 ms, have been maintained for tens of seconds. Pellet fueling allows for plasma phases with reduced ion-temperature-gradient turbulence, and during such phases, the overall confinement is so good (energy confinement times often exceeding 200 ms) that the attained density and temperature profiles would not have been possible in less optimized devices, since they would have had neoclassical transport losses exceeding the heating applied in W7-X. This provides proof that the reduction of neoclassical transport through magnetic field optimization is successful. W7-X plasmas generally show good impurity screening and high plasma purity, but there is evidence of longer impurity confinement times during turbulence-suppressed phases.

Published
2022

29. Experimental confirmation of efficient island divertor operation and successful neoclassical transport optimization in Wendelstein 7-X

Author

Sunn Pedersen, Thomas, primary, Abramovic, I., additional, Agostinetti, P., additional, Agredano Torres, M., additional, Äkäslompolo, S., additional, Alcuson Belloso, J., additional, Aleynikov, P., additional, Aleynikova, K., additional, Alhashimi, M., additional, Ali, A., additional, Allen, N., additional, Alonso, A., additional, Anda, G., additional, Andreeva, T., additional, Angioni, C., additional, Arkhipov, A., additional, Arnold, A., additional, Asad, W., additional, Ascasibar, E., additional, Aumeunier, M.-H., additional, Avramidis, K., additional, Aymerich, E., additional, Baek, S.-G., additional, Bähner, J., additional, Baillod, A., additional, Balden, M., additional, Baldzuhn, J., additional, Ballinger, S., additional, Banduch, M., additional, Bannmann, S., additional, Banon Navarro, A., additional, Bañón Navarro, A., additional, Barbui, T., additional, Beidler, C., additional, Belafdil, C., additional, Bencze, A., additional, Benndorf, A., additional, Beurskens, M., additional, Biedermann, C., additional, Biletskyi, O., additional, Blackwell, B., additional, Blatzheim, M., additional, Bluhm, T., additional, Böckenhoff, D., additional, Bongiovi, G., additional, Borchardt, M., additional, Borodin, D., additional, Boscary, J., additional, Bosch, H., additional, Bosmann, T., additional, Böswirth, B., additional, Böttger, L., additional, Bottino, A., additional, Bozhenkov, S., additional, Brakel, R., additional, Brandt, C., additional, Bräuer, T., additional, Braune, H., additional, Brezinsek, S., additional, Brunner, K., additional, Buller, S., additional, Burhenn, R., additional, Bussiahn, R., additional, Buttenschön, B., additional, Buzás, A., additional, Bykov, V., additional, Calvo, I., additional, Camacho Mata, K., additional, Caminal, I., additional, Cannas, B., additional, Cappa, A., additional, Carls, A., additional, Carovani, F., additional, Carr, M., additional, Carralero, D., additional, Carvalho, B., additional, Casas, J., additional, Castano-Bardawil, D., additional, Castejon, F., additional, Chaudhary, N., additional, Chelis, I., additional, Chomiczewska, A., additional, Coenen, J.W., additional, Cole, M., additional, Cordella, F., additional, Corre, Y., additional, Crombe, K., additional, Cseh, G., additional, Csillag, B., additional, Damm, H., additional, Day, C., additional, de Baar, M., additional, De la Cal, E., additional, Degenkolbe, S., additional, Demby, A., additional, Denk, S., additional, Dhard, C., additional, Di Siena, A., additional, Dinklage, A., additional, Dittmar, T., additional, Dreval, M., additional, Drevlak, M., additional, Drewelow, P., additional, Drews, P., additional, Dunai, D., additional, Edlund, E., additional, Effenberg, F., additional, Ehrke, G., additional, Endler, M., additional, Ennis, D.A., additional, Escoto, F.J., additional, Estrada, T., additional, Fable, E., additional, Fahrenkamp, N., additional, Fanni, A., additional, Faustin, J., additional, Fellinger, J., additional, Feng, Y., additional, Figacz, W., additional, Flom, E., additional, Ford, O., additional, Fornal, T., additional, Frerichs, H., additional, Freundt, S., additional, Fuchert, G., additional, Fukuyama, M., additional, Füllenbach, F., additional, Gantenbein, G., additional, Gao, Y., additional, Garcia, K., additional, García Regaña, J.M., additional, García-Cortés, I., additional, Gaspar, J., additional, Gates, D.A., additional, Geiger, J., additional, Geiger, B., additional, Giudicotti, L., additional, González, A., additional, Goriaev, A., additional, Gradic, D., additional, Grahl, M., additional, Graves, J.P., additional, Green, J., additional, Grelier, E., additional, Greuner, H., additional, Groß, S., additional, Grote, H., additional, Groth, M., additional, Gruca, M., additional, Grulke, O., additional, Grün, M., additional, Guerrero Arnaiz, J., additional, Günter, S., additional, Haak, V., additional, Haas, M., additional, Hacker, P., additional, Hakola, A., additional, Hallenbert, A., additional, Hammond, K., additional, Han, X., additional, Hansen, S.K., additional, Harris, J.H., additional, Hartfuß, H., additional, Hartmann, D., additional, Hathiramani, D., additional, Hatzky, R., additional, Hawke, J., additional, Hegedus, S., additional, Hein, B., additional, Heinemann, B., additional, Helander, P., additional, Henneberg, S., additional, Hergenhahn, U., additional, Hidalgo, C., additional, Hindenlang, F., additional, Hirsch, M., additional, Höfel, U., additional, Hollfeld, K.P., additional, Holtz, A., additional, Hopf, D., additional, Höschen, D., additional, Houry, M., additional, Howard, J., additional, Huang, X., additional, Hubeny, M., additional, Hudson, S., additional, Ida, K., additional, Igitkhanov, Y., additional, Igochine, V., additional, Illy, S., additional, Ionita-Schrittwieser, C., additional, Isobe, M., additional, Jabłczyńska, M., additional, Jablonski, S., additional, Jagielski, B., additional, Jakubowski, M., additional, Jansen van Vuuren, A., additional, Jelonnek, J., additional, Jenko, F., additional, Jensen, T., additional, Jenzsch, H., additional, Junghanns, P., additional, Kaczmarczyk, J., additional, Kallmeyer, J., additional, Kamionka, U., additional, Kandler, M., additional, Kasilov, S., additional, Kazakov, Y., additional, Kennedy, D., additional, Kharwandikar, A., additional, Khokhlov, M., additional, Kiefer, C., additional, Killer, C., additional, Kirschner, A., additional, Kleiber, R., additional, Klinger, T., additional, Klose, S., additional, Knauer, J., additional, Knieps, A., additional, Köchl, F., additional, Kocsis, G., additional, Kolesnichenko, Ya.I., additional, Könies, A., additional, König, R., additional, Kontula, J., additional, Kornejew, P., additional, Koschinsky, J., additional, Kozulia, M.M., additional, Krämer-Flecken, A., additional, Krampitz, R., additional, Krause, M., additional, Krawczyk, N., additional, Kremeyer, T., additional, Krier, L., additional, Kriete, D.M., additional, Krychowiak, M., additional, Ksiazek, I., additional, Kubkowska, M., additional, Kuczynski, M., additional, Kühner, G., additional, Kumar, A., additional, Kurki-Suonio, T., additional, Kwak, S., additional, Landreman, M., additional, Lang, P.T., additional, Langenberg, A., additional, Laqua, H.P., additional, Laqua, H., additional, Laube, R., additional, Lazerson, S., additional, Lewerentz, M., additional, Li, C., additional, Liang, Y., additional, Linsmeier, Ch., additional, Lion, J., additional, Litnovsky, A., additional, Liu, S., additional, Lobsien, J., additional, Loizu, J., additional, Lore, J., additional, Lorenz, A., additional, Losada, U., additional, Louche, F., additional, Lunsford, R., additional, Lutsenko, V., additional, Machielsen, M., additional, Mackel, F., additional, Maisano-Brown, J., additional, Maj, O., additional, Makowski, D., additional, Manduchi, G., additional, Maragkoudakis, E., additional, Marchuk, O., additional, Marsen, S., additional, Martines, E., additional, Martinez-Fernandez, J., additional, Marushchenko, M., additional, Masuzaki, S., additional, Maurer, D., additional, Mayer, M., additional, McCarthy, K.J., additional, Mccormack, O., additional, McNeely, P., additional, Meister, H., additional, Mendelevitch, B., additional, Mendes, S., additional, Merlo, A., additional, Messian, A., additional, Mielczarek, A., additional, Mishchenko, O., additional, Missal, B., additional, Mitteau, R., additional, Moiseenko, V.E., additional, Mollen, A., additional, Moncada, V., additional, Mönnich, T., additional, Morisaki, T., additional, Moseev, D., additional, Motojima, G., additional, Mulas, S., additional, Mulsow, M., additional, Nagel, M., additional, Naujoks, D., additional, Naulin, V., additional, Neelis, T., additional, Neilson, H., additional, Neu, R., additional, Neubauer, O., additional, Neuner, U., additional, Nicolai, D., additional, Nielsen, S.K., additional, Niemann, H., additional, Nishiza, T., additional, Nishizawa, T., additional, Nührenberg, C., additional, Ochoukov, R., additional, Oelmann, J., additional, Offermanns, G., additional, Ogawa, K., additional, Okamura, S., additional, Ölmanns, J., additional, Ongena, J., additional, Oosterbeek, J., additional, Otte, M., additional, Pablant, N., additional, Panadero Alvarez, N., additional, Pandey, A., additional, Pasch, E., additional, Pavlichenko, R., additional, Pavone, A., additional, Pawelec, E., additional, Pechstein, G., additional, Pelka, G., additional, Perseo, V., additional, Peterson, B., additional, Pilopp, D., additional, Pingel, S., additional, Pisano, F., additional, Plöckl, B., additional, Plunk, G., additional, Pölöskei, P., additional, Pompe, B., additional, Popov, A., additional, Porkolab, M., additional, Proll, J., additional, Pueschel, M.J., additional, Puiatti, M.-E., additional, Puig Sitjes, A., additional, Purps, F., additional, Rahbarnia, K., additional, Rasiński, M., additional, Rasmussen, J., additional, Reiman, A., additional, Reimold, F., additional, Reisner, M., additional, Reiter, D., additional, Richou, M., additional, Riedl, R., additional, Riemann, J., additional, Riße, K., additional, Roberg-Clark, G., additional, Rohde, V., additional, Romazanov, J., additional, Rondeshagen, D., additional, Rong, P., additional, Rudischhauser, L., additional, Rummel, T., additional, Rummel, K., additional, Runov, A., additional, Rust, N., additional, Ryc, L., additional, Salembier, P., additional, Salewski, M., additional, Sanchez, E., additional, Satake, S., additional, Satheeswaran, G., additional, Schacht, J., additional, Scharff, E., additional, Schauer, F., additional, Schilling, J., additional, Schlisio, G., additional, Schmid, K., additional, Schmitt, J., additional, Schmitz, O., additional, Schneider, W., additional, Schneider, M., additional, Schneider, P., additional, Schrittwieser, R., additional, Schröder, T., additional, Schröder, M., additional, Schroeder, R., additional, Schweer, B., additional, Schwörer, D., additional, Scott, E., additional, Shanahan, B., additional, Sias, G., additional, Sichta, P., additional, Singer, M., additional, Sinha, P., additional, Sipliä, S., additional, Slaby, C., additional, Sleczka, M., additional, Smith, H., additional, Smoniewski, J., additional, Sonnendrücker, E., additional, Spolaore, M., additional, Spring, A., additional, Stadler, R., additional, Stańczak, D., additional, Stange, T., additional, Stepanov, I., additional, Stephey, L., additional, Stober, J., additional, Stroth, U., additional, Strumberger, E., additional, Suzuki, C., additional, Suzuki, Y., additional, Svensson, J., additional, Szabolics, T., additional, Szepesi, T., additional, Szücs, M., additional, Tabarés, F.L., additional, Tamura, N., additional, Tancetti, A., additional, Tantos, C., additional, Terry, J., additional, Thienpondt, H., additional, Thomsen, H., additional, Thumm, M., additional, Travere, J.M., additional, Traverso, P., additional, Tretter, J., additional, Trier, E., additional, Trimino Mora, H., additional, Tsujimura, T., additional, Turkin, Y., additional, Tykhyi, A., additional, Unterberg, B., additional, van Eeten, P., additional, van Milligen, B.Ph., additional, van Schoor, M., additional, Vano, L., additional, Varoutis, S., additional, Vecsei, M., additional, Vela, L., additional, Velasco, J.L., additional, Vervier, M., additional, Vianello, N., additional, Viebke, H., additional, Vilbrandt, R., additional, Vogel, G., additional, Vogt, N., additional, Volkhausen, C., additional, von Stechow, A., additional, Wagner, F., additional, Wang, E., additional, Wang, H., additional, Warmer, F., additional, Wauters, T., additional, Wegener, L., additional, Wegner, T., additional, Weir, G., additional, Wenzel, U., additional, White, A., additional, Wilde, F., additional, Wilms, F., additional, Windisch, T., additional, Winkler, M., additional, Winter, A., additional, Winters, V., additional, Wolf, R., additional, Wright, A.M., additional, Wurden, G.A., additional, Xanthopoulos, P., additional, Xu, S., additional, Yamada, H., additional, Yamaguchi, H., additional, Yokoyama, M., additional, Yoshinuma, M., additional, Yu, Q., additional, Zamanov, M., additional, Zanini, M., additional, Zarnstorff, M., additional, Zhang, D., additional, Zhou, S., additional, Zhu, J., additional, Zhu, C., additional, Zilker, M., additional, Zocco, A., additional, Zohm, H., additional, Zoletnik, S., additional, and Zsuga, L., additional

Published
2022
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30. Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group

Author

Santos García D, García Roca L, de Deus Fonticoba T, Cores Bartolomé C, Naya Ríos L, Canfield H, Paz González JM, Martínez Miró C, Jesús S, Aguilar M, Pastor P, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Blázquez Estrada M, Seijo M, Rúiz Martínez J, Valero C, Kurtis M, de Fábregues O, González Ardura J, Alonso Redondo R, Ordás C, López Díaz L LM, McAfee D, Martinez-Martin P, Mir P, and COPPADIS Study Group

Subjects
impairment, Cognition, Parkinson's disease, constipation, non-motor symptoms
Abstract

Background: Constipation has been linked to cognitive impairment development in Parkinson's disease (PD). Objective: Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods: PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson's Disease Cognitive Rating Scale). Subjects with a score >= 1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as "with constipation". Regression analyses were applied for determining the contribution of constipation in cognitive changes. Results: At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p < 0.0001). No change was observed in cognitive status (PD-CRS total score) neither in controls without constipation (from 100.24 +/- 13.72 to 100.27 +/- 13.68; p = 0.971) and with constipation (from 94.71 +/- 10.96 to 93.93 +/- 13.03; p = 0.615). The PD-CRS total score decreased significantly in PD patients with constipation (from 89.14 +/- 15.36 to 85.97 +/- 18.09; p

Published
2022

31. Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism

Author

Martinez-Urbistondo D., de la Garza R. G., Villares-Fernandez P., Font C., Schellong S., Lopez-Nunez J. J., Gil-Diaz A., del Carmen Diaz-Pedroche M., Hirmerova J., Monreal M., Adarraga M., Aibar J., Alonso J., Amado C., Arcelus J., Asuero A., Ballaz A., Barba R., Barbagelata C., Barron M., Barron-Andres B., Blanco-Molina A., Beddar Chaib F., Botella E., Castro J., Chasco L., Criado J., de Ancos C., del Toro J., Demelo-Rodriguez P., Diaz-Brasero A., Diaz-Pedroche M., Diaz-Peromingo J., Di Campli M., Dubois-Silva A., Escribano J., Esposito F., Farfan-Sedano A., Fernandez-Capitan C., Fernandez-Reyes J., Fidalgo M., Flores K., Font L., Francisco I., Gabara C., Galeano-Valle F., Garcia M., Garcia-Bragado F., Garcia de Herreros M., de la Garza R., Garcia-Diaz C., Gomez-Cuervo C., Grau E., Guirado L., Gutierrez J., Hernandez-Blasco L., Jara-Palomares L., Jaras M., Jimenez D., Jimenez R., Jimenez-Alfaro C., Joya M., Lainez-Justo S., Lalueza A., Latorre A., Lima J., Lobo J., Lopez-Jimenez L., Lopez-Miguel P., Lopez-Nunez J., Lopez-Reyes R., Lopez-Saez J., Lorenzo A., Madridano O., Maestre A., Marchena P., Martin del Pozo M., Martin-Martos F., Mella C., Mercado M., Moises J., Munoz-Blanco A., Nieto J., Nofuentes-Perez E., Nunez-Fernandez M., Olid-Velilla M., Olivares M., Osorio J., Otalora S., Otero R., Paredes D., Pedrajas J., Porras J., Portillo J., Redondo I., Rodriguez-Matute C., Rosa V., Ruiz-Artacho P., Ruiz-Ruiz J., Salgueiro G., Sanchez-Martinez R., Sanchez-Munoz-Torrero J., Sancho T., Soler S., Suarez-Rodriguez B., Surinach J., Torres M., Torres-Sanchez A., Tolosa C., Trujillo-Santos J., Uresandi F., Valero B., Valle R., Varona J., Vela L., Vela J., Vidal G., Villalobos A., Villares P., Zamora C., Ay C., Nopp S., Pabinger I., Engelen M., Vanassche T., Verhamme P., Maly R., Accassat S., Ait Abdallah N., Bertoletti L., Bura-Riviere A., Catella J., Couturaud F., Crichi B., Debourdeau P., Espitia O., Farge-Bancel D., Grange C., Helfer H., Lacut K., Le Mao R., Mahe I., Morange P., Moustafa F., Poenou G., Sarlon-Bartoli G., Suchon P., Quere I., Braester A., Brenner B., Kenet G., Tzoran I., Basaglia M., Bilora F., Bortoluzzi C., Brandolin B., Ciammaichella M., De Angelis A., Di Micco P., Imbalzano E., Merla S., Pesavento R., Prandoni P., Siniscalchi C., Tufano A., Visona A., Vo Hong N., Zalunardo B., Nishimoto Y., Sato Y., Make K., Skride A., Strautmane S., Fonseca S., Martins F., Meireles J., Bosevski M., Bounameaux H., Mazzolai L., Caprini J., Bui H., Martinez-Urbistondo, D., de la Garza, R. G., Villares-Fernandez, P., Font, C., Schellong, S., Lopez-Nunez, J. J., Gil-Diaz, A., del Carmen Diaz-Pedroche, M., Hirmerova, J., Monreal, M., Adarraga, M., Aibar, J., Alonso, J., Amado, C., Arcelus, J., Asuero, A., Ballaz, A., Barba, R., Barbagelata, C., Barron, M., Barron-Andres, B., Blanco-Molina, A., Beddar Chaib, F., Botella, E., Castro, J., Chasco, L., Criado, J., de Ancos, C., del Toro, J., Demelo-Rodriguez, P., Diaz-Brasero, A., Diaz-Pedroche, M., Diaz-Peromingo, J., Di Campli, M., Dubois-Silva, A., Escribano, J., Esposito, F., Farfan-Sedano, A., Fernandez-Capitan, C., Fernandez-Reyes, J., Fidalgo, M., Flores, K., Font, L., Francisco, I., Gabara, C., Galeano-Valle, F., Garcia, M., Garcia-Bragado, F., Garcia de Herreros, M., de la Garza, R., Garcia-Diaz, C., Gomez-Cuervo, C., Grau, E., Guirado, L., Gutierrez, J., Hernandez-Blasco, L., Jara-Palomares, L., Jaras, M., Jimenez, D., Jimenez, R., Jimenez-Alfaro, C., Joya, M., Lainez-Justo, S., Lalueza, A., Latorre, A., Lima, J., Lobo, J., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J., Lopez-Reyes, R., Lopez-Saez, J., Lorenzo, A., Madridano, O., Maestre, A., Marchena, P., Martin del Pozo, M., Martin-Martos, F., Mella, C., Mercado, M., Moises, J., Munoz-Blanco, A., Nieto, J., Nofuentes-Perez, E., Nunez-Fernandez, M., Olid-Velilla, M., Olivares, M., Osorio, J., Otalora, S., Otero, R., Paredes, D., Pedrajas, J., Porras, J., Portillo, J., Redondo, I., Rodriguez-Matute, C., Rosa, V., Ruiz-Artacho, P., Ruiz-Ruiz, J., Salgueiro, G., Sanchez-Martinez, R., Sanchez-Munoz-Torrero, J., Sancho, T., Soler, S., Suarez-Rodriguez, B., Surinach, J., Torres, M., Torres-Sanchez, A., Tolosa, C., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Varona, J., Vela, L., Vela, J., Vidal, G., Villalobos, A., Villares, P., Zamora, C., Ay, C., Nopp, S., Pabinger, I., Engelen, M., Vanassche, T., Verhamme, P., Maly, R., Accassat, S., Ait Abdallah, N., Bertoletti, L., Bura-Riviere, A., Catella, J., Couturaud, F., Crichi, B., Debourdeau, P., Espitia, O., Farge-Bancel, D., Grange, C., Helfer, H., Lacut, K., Le Mao, R., Mahe, I., Morange, P., Moustafa, F., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Quere, I., Braester, A., Brenner, B., Kenet, G., Tzoran, I., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., De Angelis, A., Di Micco, P., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Siniscalchi, C., Tufano, A., Visona, A., Vo Hong, N., Zalunardo, B., Nishimoto, Y., Sato, Y., Make, K., Skride, A., Strautmane, S., Fonseca, S., Martins, F., Meireles, J., Bosevski, M., Bounameaux, H., Mazzolai, L., Caprini, J., and Bui, H.

Subjects
medicine.medical_specialty, VTE risk assessment, Healthy individual, Elevated liver enzymes, Hemorrhage, Gastroenterology, Liver disease, Recurrence, Fibrosis, Internal medicine, Internal Medicine, medicine, Anticoagulation adverse event, Humans, In patient, Registries, Clinical VTE, business.industry, Liver Diseases, Anticoagulants, Venous Thromboembolism, medicine.disease, Im - Original, Non-invasive liver assessment, Healthy individuals, Increased risk, Anticoagulant therapy, Emergency Medicine, Anticoagulation adverse events, business, Venous thromboembolism, Major bleeding
Abstract

The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbólica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10–2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04–2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation. Supplementary Information The online version contains supplementary material available at 10.1007/s11739-021-02858-x.

Published
2021

33. Heart Rate and Mortality in Patients With Acute Symptomatic Pulmonary Embolism

Author

Jaureguízar, Ana, primary, Jiménez, David, additional, Bikdeli, Behnood, additional, Ruiz-Artacho, Pedro, additional, Muriel, Alfonso, additional, Tapson, Victor, additional, López-Reyes, Raquel, additional, Valero, Beatriz, additional, Kenet, Gili, additional, Monreal, Manuel, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge-Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, M.D., additional, Aibar, J., additional, Aibar, M.A., additional, Alonso, J., additional, Amado, C., additional, Arcelus, J.I., additional, Asuero, A., additional, Azcarate-Agüero, P., additional, Ballaz, A., additional, Barba, R., additional, Barbagelata, C., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Blanco-Molina, A., additional, Beddar Chaib, F., additional, Camon, A.M., additional, Castro, J., additional, Chasco, L., additional, Criado, J., additional, de Ancos, C., additional, del Toro, J., additional, Demelo-Rodríguez, P., additional, Díaz-Brasero, A.M., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Di Campli, M.V., additional, Dubois-Silva, A., additional, Escribano, J.C., additional, Espósito, F., additional, Farfán-Sedano, A.I., additional, Fernández-Capitán, C., additional, Fernández-Reyes, J.L., additional, Fidalgo, M.A., additional, Flores, K., additional, Font, C., additional, Font, L., additional, Francisco, I., additional, Gabara, C., additional, Galeano-Valle, F., additional, García, M.A., additional, García-Bragado, F., additional, García de Herreros, M., additional, García de la Garza, R., additional, García-Díaz, C., additional, Gil-Díaz, A., additional, Gómez-Cuervo, C., additional, Giménez-Suau, M., additional, Grau, E., additional, Guirado, L., additional, Gutiérrez, J., additional, Hernández-Blasco, L., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Jiménez-Alfaro, C., additional, Joya, M.D., additional, Lainez-Justo, S., additional, Latorre, A., additional, Lima, J., additional, Lobo, J.L., additional, López-Jiménez, L., additional, López-Miguel, P., additional, López-Núñez, J.J., additional, López-Reyes, R., additional, López-Sáez, J.B., additional, Lorenzo, A., additional, Madridano, O., additional, Maestre, A., additional, Marchena, P.J., additional, Martín del Pozo, M., additional, Martín-Martos, F., additional, Martínez-Urbistondo, D., additional, Mella, C., additional, Mercado, M.I., additional, Moisés, J., additional, Monreal, M., additional, Muñoz, M., additional, Muñoz-Blanco, A., additional, Nieto, J.A., additional, Nofuentes-Pérez, E., additional, Núñez-Fernández, M.J., additional, Olid-Velilla, M., additional, Olivares, M.C., additional, Osorio, J., additional, Otalora, S., additional, Otero, R., additional, Pedrajas, J.M., additional, Pellejero, G., additional, Porras, J.A., additional, Portillo, J., additional, Rodríguez-Matute, C., additional, Rosa, V., additional, Ruiz-Artacho, P., additional, Ruiz-Ruiz, J., additional, Salgueiro, G., additional, Sánchez-Martínez, R., additional, Sánchez-Muñoz-Torrero, J.F., additional, Sancho, T., additional, Soler, S., additional, Suárez-Rodríguez, B., additional, Suriñach, J.M., additional, Torres, M.I., additional, Tolosa, C., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Valero, B., additional, Valle, R., additional, Varona, J.F., additional, Vela, L., additional, Vela, J.R., additional, Vidal, G., additional, Villalobos, A., additional, Villares, P., additional, Zamora, C., additional, Ay, C., additional, Nopp, S., additional, Pabinger, I., additional, Vanassche, T., additional, Vandenbriele, C., additional, Verhamme, P., additional, Hirmerova, J., additional, Malý, R., additional, Accassat, S., additional, Ait Abdallah, N., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Catella, J., additional, Couturaud, F., additional, Crichi, B., additional, Debourdeau, P., additional, Espitia, O., additional, Farge-Bancel, D., additional, Grange, C., additional, Helfer, H., additional, Lacut, K., additional, Le Mao, R., additional, Mahé, I., additional, Morange, P., additional, Moustafa, F., additional, Poenou, G., additional, Sarlon-Bartoli, G., additional, Suchon, P., additional, Quere, I., additional, Schellong, S., additional, Braester, A., additional, Brenner, B., additional, Kenet, G., additional, Tzoran, I., additional, Basaglia, M., additional, Bilora, F., additional, Bortoluzzi, C., additional, Brandolin, B., additional, Ciammaichella, M., additional, De Angelis, A., additional, Di Micco, P., additional, Imbalzano, E., additional, Merla, S., additional, Pesavento, R., additional, Prandoni, P., additional, Siniscalchi, C., additional, Tufano, A., additional, Visonà, A., additional, Vo Hong, N., additional, Zalunardo, B., additional, Nishimoto, Y., additional, Sato, Y., additional, Birzulis, J., additional, Skride, A., additional, Zaicenko, A., additional, Fonseca, S., additional, Martins, F., additional, Meireles, J., additional, Bosevski, M., additional, Krstevski, G., additional, Bounameaux, H., additional, Mazzolai, L., additional, Bikdeli, B., additional, Caprini, J.A., additional, and Bui, H.M., additional

Published
2022
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37. Predictors of clinically significant quality of life impairment in Parkinson's disease

Author

Garcia D, Fonticoba T, Cores C, Munoz G, Gonzalez J, Miro C, Suarez E, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Catalan M, Nogueira V, Puente V, de Arcos M, Borrue C, Vila B, Sauco M, Vela L, Escalante S, Cubo E, Padilla F, Castrillo J, Alonso P, Losada M, Ariztegui N, Gaston I, Clavero P, Kulisevsky J, Estrada M, Seijo M, Martinez J, Valero C, Kurtis M, de Fabregues O, Ardura J, Ordas C, Diaz L, McAfee D, Martinez-Martin P, Mir P, and COPPADIS Study Grp

Abstract

Quality of life (QOL) plays an important role in independent living in Parkinson's disease (PD) patients, being crucial to know what factors impact QoL throughout the course of the disease. Here we identified predictors of QoL impairment in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS cohort from January 2016, to November 2017, were followed up during 2 years. Health-related QoL (HRQoL) and global QoL (GQoL) were assessed with the 39-item Parkinson's disease Questionnaire (PDQ-39) and the EUROHIS-QOL 8-item index (EUROHIS-QOL8), respectively, at baseline (V0) and at 24 months +/- 1 month (V2). Clinically significant QoL impairment was defined as presenting an increase (PDQ-39SI) or decrement (EUROHIS-QOL8) at V2 >= 10% of the score at baseline (V0). A comparison with a control group was conducted for GQoL. GQoL did not change significantly in PD patients (N = 507; p = 0.686) or in the control group (N = 119; p = 0.192). The mean PDQ-39SI was significantly increased in PD patients (62.7 +/- 8.5 years old; 58.8% males; N = 500) by 21.6% (from 16.7 +/- 13 to 20.3 +/- 16.4; p < 0.0001) at V2. Ninety-three patients (18.6%) presented a clinically significant HRQoL impairment at V2. To be younger (OR = 0.896; 95% CI 0.829-0.968; p = 0.006), to be a female (OR = 4.181; 95% CI 1.422-12.290; p = 0.009), and to have a greater increase in BDI-II (Beck Depression Inventory-II) (OR = 1.139; 95% CI 1.053-1.231; p = 0.001) and NMSS (Non-Motor Symptoms Scale) (OR = 1.052; 95% CI 1.027-1.113; p < 0.0001) total scores from V0 to V2 were associated with clinically significant HRQoL impairment at the 2-year follow-up (Hosmer-Lemeshow test, p = 0.665; R-2 = 0.655). An increase in >= 5 and >= 10 points of BDI-II and NMSS total score at V2 multiplied the probability of presenting clinically significant HRQoL impairment by 5 (OR = 5.453; 95% CI 1.663-17.876; p = 0.005) and 8 (OR = 8.217; 95% CI, 2.975-22.696; p = 0.002), respectively. In conclusion, age, gender, mood, and non-motor impairment were associated with clinically significant HRQoL impairment after the 2-year follow-up in PD patients.

Published
2021

38. Demonstration of reduced neoclassical energy transport in Wendelstein 7-X

Author

W7-X Team, Beidler, C. D., Smith, H. M., Alonso, A., Andreeva, T., Baldzuhn, J., Beurskens, M. N. A., Borchardt, M., Bozhenkov, S. A., Brunner, K. J., Damm, H., Drevlak, M., Ford, O. P., Fuchert, G., Geiger, J., Helander, P., Hergenhahn, U., Hirsch, M., Höfel, U., Kazakov, Ye. O., Kleiber, R., Krychowiak, M., Kwak, S., Langenberg, A., Laqua, H. P., Neuner, U., Pablant, N. A., Pasch, E., Pavone, A., Pedersen, T. S., Rahbarnia, K., Schilling, J., Scott, E. R., Stange, T., Svensson, J., Thomsen, H., Turkin, Y., Warmer, F., Wolf, R. C., Zhang, D., Abramovic, I., Äkäslompolo, S., Alcusón, J., Aleynikov, P., Aleynikova, K., Ali, A., Anda, G., Ascasibar, E., Bähner, J. P., Baek, S. G., Balden, M., Banduch, M., Barbui, T., Behr, W., Benndorf, A., Biedermann, C., Biel, W., Blackwell, B., Blanco, E., Blatzheim, M., Ballinger, S., Bluhm, T., Böckenhoff, D., Böswirth, B., Böttger, L.-G., Borsuk, V., Boscary, J., Bosch, H.-S., Brakel, R., Brand, H., Brandt, C., Bräuer, T., Braune, H., Brezinsek, S., Brunner, K.-J., Burhenn, R., Bussiahn, R., Buttenschön, B., Bykov, V., Cai, J., Calvo, I., Cannas, B., Cappa, A., Carls, A., Carraro, L., Carvalho, B., Castejon, F., Charl, A., Chaudhary, N., Chauvin, D., Chernyshev, F., Cianciosa, M., Citarella, R., Claps, G., Coenen, J., Cole, M., Cole, M. J., Cordella, F., Cseh, G., Czarnecka, A., Czerski, K., Czerwinski, M., Czymek, G., Molin, A. da, Silva, A. da, Pena, A. de la, Degenkolbe, S., Dhard, C. P., Dibon, M., Dinklage, A., Dittmar, T., Drewelow, P., Drews, P., Durodie, F., Edlund, E., Effenberg, F., Ehrke, G., Elgeti, S., Endler, M., Ennis, D., Esteban, H., Estrada, T., Fellinger, J., Feng, Y., Flom, E., Fernandes, H., Fietz, W. H., Figacz, W., Fontdecaba, J., Fornal, T., Frerichs, H., Freund, A., Funaba, T., Galkowski, A., Gantenbein, G., Gao, Y., García Regaña, J., Gates, D., Geiger, B., Giannella, V., Gogoleva, A., Goncalves, B., Goriaev, A., Gradic, D., Grahl, M., Green, J., Greuner, H., Grosman, A., Grote, H., Gruca, M., Grulke, O., Guerard, C., Hacker, P., Han, X., Harris, J. H., Hartmann, D., Hathiramani, D., Hein, B., Heinemann, B., Henneberg, S., Henkel, M., Hernandez Sanchez, J., Hidalgo, C., Hollfeld, K. P., Hölting, A., Höschen, D., Houry, M., Howard, J., Huang, X., Huang, Z., Hubeny, M., Huber, M., Hunger, H., Ida, K., Ilkei, T., Illy, S., Israeli, B., Jablonski, S., Jakubowski, M., Jelonnek, J., Jenzsch, H., Jesche, T., Jia, M., Junghanns, P., Kacmarczyk, J., Kallmeyer, J.-P., Kamionka, U., Kasahara, H., Kasparek, W., Kenmochi, N., Killer, C., Kirschner, A., Klinger, T., Knauer, J., Knaup, M., Knieps, A., Kobarg, T., Kocsis, G., Köchl, F., Kolesnichenko, Y., Könies, A., König, R., Kornejew, P., Koschinsky, J.-P., Köster, F., Krämer, M., Krampitz, R., Krämer-Flecken, A., Krawczyk, N., Kremeyer, T., Krom, J., Ksiazek, I., Kubkowska, M., Kühner, G., Kurki-Suonio, T., Kurz, P. A., Landreman, M., Lang, P., Lang, R., Langish, S., Laqua, H., Laube, R., Lazerson, S., Lechte, C., Lennartz, M., Leonhardt, W., Li, C., Li, Y., Liang, Y., Linsmeier, C., Liu, S., Lobsien, J.-F., Loesser, D., Loizu Cisquella, J., Lore, J., Lorenz, A., Losert, M., Lücke, A., Lumsdaine, A., Lutsenko, V., Maaßberg, H., Marchuk, O., Matthew, J. H., Marsen, S., Marushchenko, M., Masuzaki, S., Maurer, D., Mayer, M., McCarthy, K., McNeely, P., Meier, A., Mellein, D., Mendelevitch, B., Mertens, P., Mikkelsen, D., Mishchenko, A., Missal, B., Mittelstaedt, J., Mizuuchi, T., Mollen, A., Moncada, V., Mönnich, T., Morisaki, T., Moseev, D., Murakami, S., Náfrádi, G., Nagel, M., Naujoks, D., Neilson, H., Neu, R., Neubauer, O., Ngo, T., Nicolai, D., Nielsen, S. K., Niemann, H., Nishizawa, T., Nocentini, R., Nührenberg, C., Nührenberg, J., Obermayer, S., Offermanns, G., Ogawa, K., Ölmanns, J., Ongena, J., Oosterbeek, J. W., Orozco, G., Otte, M., Pacios Rodriguez, L., Panadero, N., Panadero Alvarez, N., Papenfuß, D., Paqay, S., Pawelec, E., Pelka, G., Perseo, V., Peterson, B., Pilopp, D., Pingel, S., Pisano, F., Plaum, B., Plunk, G., Pölöskei, P., Porkolab, M., Proll, J., Puiatti, M.-E., Puig Sitjes, A., Purps, F., Rack, M., Récsei, S., Reiman, A., Reimold, F., Reiter, D., Remppel, F., Renard, S., Riedl, R., Riemann, J., Risse, K., Rohde, V., Röhlinger, H., Romé, M., Rondeshagen, D., Rong, P., Roth, B., Rudischhauser, L., Rummel, K., Rummel, T., Runov, A., Rust, N., Ryc, L., Ryosuke, S., Sakamoto, R., Salewski, M., Samartsev, A., Sanchez, M., Sano, F., Satake, S., Schacht, J., Satheeswaran, G., Schauer, F., Scherer, T., Schlaich, A., Schlisio, G., Schluck, F., Schlüter, K.-H., Schmitt, J., Schmitz, H., Schmitz, O., Schmuck, S., Schneider, M., Schneider, W., Scholz, P., Schrittwieser, R., Schröder, M., Schröder, T., Schroeder, R., Schumacher, H., Schweer, B., Sereda, S., Shanahan, B., Sibilia, M., Sinha, P., Sipliä, S., Slaby, C., Sleczka, M., Spiess, W., Spong, D. A., Spring, A., Stadler, R., Stejner, M., Stephey, L., Stridde, U., Suzuki, C., Szabó, V., Szabolics, T., Szepesi, T., Szökefalvi-Nagy, Z., Tamura, N., Tancetti, A., Terry, J., Thomas, J., Thumm, M., Travere, J. M., Traverso, P., Tretter, J., Trimino Mora, H., Tsuchiya, H., Tsujimura, T., Tulipán, S., Unterberg, B., Vakulchyk, I., Valet, S., Vanó, L., Eeten, P. van, Milligen, B. van, Vuuren, A. J. van, Vela, L., Velasco, J.-L., Vergote, M., Vervier, M., Vianello, N., Viebke, H., Vilbrandt, R., Stechow, A. von, Vorköper, A., Wadle, S., Wagner, F., Wang, E., Wang, N., Wang, Z., Wauters, T., Wegener, L., Weggen, J., Wegner, T., Wei, Y., Weir, G., Wendorf, J., Wenzel, U., Werner, A., White, A., Wiegel, B., Wilde, F., Windisch, T., Winkler, M., Winter, A., Winters, V., Wolf, S., Wright, A., Wurden, G., Xanthopoulos, P., Yamada, H., Yamada, I., Yasuhara, R., Yokoyama, M., Zanini, M., Zarnstorff, M., Zeitler, A., Zhang, H., Zhu, J., Zilker, M., Zocco, A., Zoletnik, S., Zuin, M., W7-X Team, Max Planck Institute for Plasma Physics, Max Planck Society, Applied Physics and Science Education, Science and Technology of Nuclear Fusion, Turbulence in Fusion Plasmas, and European Commission

Subjects
Magnetically Confined Plasmas, Tokamak, Design, Helias, Nuclear engineering, Magnetically confined plasmas, 01 natural sciences, 7. Clean energy, Article, Plasma physics, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, 0103 physical sciences, Nuclear fusion, 010306 general physics, Engineering & allied operations, Stellarator, Physics, Plasma fusion, Multidisciplinary, Toroid, biology, Plasma Physics, Física, Magnetic confinement fusion, Plasma, biology.organism_classification, Energía Nuclear, ddc:620, Wendelstein 7-X
Abstract

Research on magnetic confinement of high-temperature plasmas has the ultimate goal of harnessing nuclear fusion for the production of electricity. Although the tokamak1 is the leading toroidal magnetic-confinement concept, it is not without shortcomings and the fusion community has therefore also pursued alternative concepts such as the stellarator. Unlike axisymmetric tokamaks, stellarators possess a three-dimensional (3D) magnetic field geometry. The availability of this additional dimension opens up an extensive configuration space for computational optimization of both the field geometry itself and the current-carrying coils that produce it. Such an optimization was undertaken in designing Wendelstein 7-X (W7-X)2, a large helical-axis advanced stellarator (HELIAS), which began operation in 2015 at Greifswald, Germany. A major drawback of 3D magnetic field geometry, however, is that it introduces a strong temperature dependence into the stellarator’s non-turbulent ‘neoclassical’ energy transport. Indeed, such energy losses will become prohibitive in high-temperature reactor plasmas unless a strong reduction of the geometrical factor associated with this transport can be achieved; such a reduction was therefore a principal goal of the design of W7-X. In spite of the modest heating power currently available, W7-X has already been able to achieve high-temperature plasma conditions during its 2017 and 2018 experimental campaigns, producing record values of the fusion triple product for such stellarator plasmas3,4. The triple product of plasma density, ion temperature and energy confinement time is used in fusion research as a figure of merit, as it must attain a certain threshold value before net-energy-producing operation of a reactor becomes possible1,5. Here we demonstrate that such record values provide evidence for reduced neoclassical energy transport in W7-X, as the plasma profiles that produced these results could not have been obtained in stellarators lacking a comparably high level of neoclassical optimization., Previously documented record values of the fusion triple product in the stellarator Wendelstein 7-X are shown to be evidence for reduced neoclassical energy transport in this optimized device.

Published
2021
Full Text
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39. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Author

Chen, Z., Zhang, D., Reynolds, R.H., Gustavsson, E.K., García-Ruiz, S., D'Sa, K., Fairbrother-Browne, A., Vandrovcova, J., Noyce, A.J., Kaiyrzhanov, R., Middlehurst, B., Kia, D.A., Tan, M., Morris, H.R., Plun-Favreau, H., Holmans, P., Trabzuni, D., Bras, J., Quinn, J., Mok, K.Y., Kinghorn, K.J., Billingsley, K., Wood, N.W., Lewis, P., Schreglmann, S., Guerreiro, Rita, Lovering, R., R'Bibo, L., Manzoni, C., Rizig, M., Guelfi, S., Escott-Price, V., Chelban, V., Foltynie, T., Williams, N., Brice, A., Danjou, F., Lesage, S., Corvol, Jean-Christophe, Martinez, M., Schulte, C., Brockmann, K., Simón-Sánchez, J., Heutink, P., Rizzu, P., Sharma, M., Gasser, T., Nicolas, A., Cookson, M. R, Bandres-Ciga, S., Blauwendraat, Cornelis, Craig, David W, Faghri, F., Gibbs, J.R., Hernandez, D.G., Van Keuren-Jensen, K., Shulman, J.M., Leonard, H.L., Nalls, M.A., Robak, L., Lubbe, S., Finkbeiner, S., Mencacci, N.E., Lungu, C., Singleton, A. B., Scholz, S.W., Reed, X., Alcalay, Roy N, Gan-Or, Z., Rouleau, G.A., Krohn, L., van Hilten, J.J., Marinus, J., Adarmes-Gómez, A.D, Aguilar Barberà, Miquel, Alvarez, Ignacio, Alvarez, V., Barrero, F. J, Yarza, J.A.B., Bernal-Bernal, I., Blazquez, M., Bonilla-Toribio, Marta, Botía, J., Boungiorno, M.T., Buiza-Rueda, Dolores, Cámara, Ana, Carrillo, F., Carrión-Claro, M., Cerdan, D., Clarimón, Jordi, Compta, Yaroslau, Diez-Fairen, M., Dols Icardo, Oriol, Duarte, J., Duran, Raquel, Escamilla-Sevilla, F., Ezquerra, M., Feliz, C., Fernández, M., Fernández-Santiago, R., Garcia, C., García-Ruiz, P., Gómez-Garre, P., Heredia, M.J.G., Gonzalez-Aramburu, I., Pagola, A.G., Hoenicka, J., Infante, J., Jesús, S., Jimenez-Escrig, A., Kulisevsky, Jaime, Labrador-Espinosa, Miguel A, Lopez-Sendon, J.L., de Munain Arregui, A.L., Macias, D., Torres, I.M., Marín, J., Marti, M.J., Martínez-Castrillo, J.C., Méndez-del-Barrio, C., González, M.M., Mata, M., Mínguez, A., Mir, P., Rezola, E.M., Muñoz, E., Pagonabarraga Mora, Javier, Pastor, P., Errazquin, F.P., Periñán-Tocino, T., Ruiz-Martínez, J., Ruz, C., Rodriguez, A.S., Sierra, M., Suarez-Sanmartin, E., Tabernero, C., Tartari, J. P., Tejera-Parrado, C., Tolosa, E., Valldeoriola, F., Vargas-González, L., Vela, L., Vives, F., Zimprich, Alexander, Pihlstrom, L., Toft, M., Koks, S., Taba, P., Hassin-Baer, S., Hardy, J., Houlden, Henry, Gagliano Taliun, S. A., Ryten, M., Universitat Autònoma de Barcelona, Universidad de Cantabria, Lord Leonard and Lady Estelle Wolfson Foundation, Medical Research Council (UK), Dementia Research Institute (UK), Alzheimer Society, Alzheimer's Research UK, Wellcome Trust, Dolby Family Fund, National Institute for Health Research (UK), NIHR Biomedical Research Centre (UK), Agencia Estatal de Investigación (España), Fundación Séneca, and Gobierno de la Región de Murcia

Subjects
0301 basic medicine, Apolipoprotein E, Aging, Messenger, General Physics and Astronomy, Neurodegenerative, Alzheimer's Disease, Genome, Linkage Disequilibrium, Negative selection, 0302 clinical medicine, 2.1 Biological and endogenous factors, Aetiology, health care economics and organizations, Conserved Sequence, Phylogeny, Multidisciplinary, Brain, Neurodegenerative Diseases, Single Nucleotide, Alzheimer's disease, Phenotype, International Parkinson’s Disease Genomics Consortium, Neurological, Regression Analysis, Long Noncoding, DNA, Intergenic, RNA, Long Noncoding, Human, Biotechnology, Lineage (genetic), Science, 1.1 Normal biological development and functioning, Computational biology, Biology, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, Chromosomes, 03 medical and health sciences, Apolipoproteins E, Underpinning research, Alzheimer Disease, Genetic variation, Genetics, Acquired Cognitive Impairment, Humans, RNA, Messenger, Polymorphism, Gene, Whole genome sequencing, Intergenic, Pair 19, Genome, Human, Human Genome, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Molecular Sequence Annotation, General Chemistry, DNA, Introns, Brain Disorders, 030104 developmental biology, Gene Ontology, RNA, Dementia, Chromosomes, Human, Pair 19, 030217 neurology & neurosurgery
Abstract

Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic variation (constrained regions) and poorly conserved across primates. We propose that these constrained, non-conserved regions (CNCRs) have been subject to human-specific purifying selection and are enriched for brain-specific elements. We find that CNCRs are depleted from protein-coding genes but enriched within lncRNAs. We demonstrate that per-SNP heritability of a range of brain-relevant phenotypes are enriched within CNCRs. We find that genes implicated in neurological diseases have high CNCR density, including APOE, highlighting an unannotated intron-3 retention event. Using human brain RNA-sequencing data, we show the intron-3-retaining transcript to be more abundant in Alzheimer’s disease with more severe tau and amyloid pathological burden. Thus, we demonstrate potential association of human-lineage-specific sequences in brain development and neurological disease., Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.

Published
2021

40. Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease

Author

Leonard H, Lake J, Kim JJ, Gibbs JR, Ruskey JA, Pihlstrøm L, Eerola-Rautio J, Tienari PJ, Grosset DG, Wood N, Noyce AJ, Middlehurst B, Kia DA, Tan M, Houlden H, Storm CS, Morris HR, Plun-Favreau H, Holmans P, Hardy J, Trabzuni D, Quinn J, Bubb V, Mok KY, Kinghorn KJ, Wood NW, Lewis P, Schreglmann SR, Lovering R, R'Bibo L, Manzoni C, Rizig M, Ryten M, Guelfi S, Escott-Price V, Chelban V, Foltynie T, Williams N, Morrison KE, Clarke C, Harvey K, Jacobs BM, Brice A, Danjou F, Lesage S, Corvol JC, Martinez M, Schulte C, Brockmann K, Simón-Sánchez J, Heutink P, Rizzu P, Sharma M, Gasser T, Schneider SA, Cookson MR, Bandres-Ciga S, Blauwendraat C, Craig DW, Billingsley K, Makarious MB, Narendra DP, Faghri F, Hernandez DG, Van Keuren-Jensen K, Shulman JM, Iwaki H, Leonard HL, Nalls MA, Robak L, Bras J, Guerreiro R, Lubbe S, Troycoco T, Finkbeiner S, Mencacci NE, Lungu C, Singleton AB, Scholz SW, Reed X, Uitti RJ, Ross OA, Grenn FP, Moore A, Alcalay RN, Wszolek ZK, Gan-Or Z, Rouleau GA, Krohn L, Mufti K, van Hilten JJ, Marinus J, Adarmes-Gómez AD, Aguilar M, Alvarez I, Alvarez V, Barrero FJ, Yarza JAB, Bernal-Bernal I, Blazquez M, Bonilla-Toribio M, Botía JA, Boungiorno MT, Buiza-Rueda D, Cámara A, Carrillo F, Carrión-Claro M, Cerdan D, Clarimón J, Compta Y, Diez-Fairen M, Dols-Icardo O, Duarte J, Duran R, Escamilla-Sevilla F, Ezquerra M, Feliz C, Fernández M, Fernández-Santiago R, Garcia C, García-Ruiz P, Gómez-Garre P, Heredia MJG, Gonzalez-Aramburu I, Pagola AG, Hoenicka J, Infante J, Jesús S, Jimenez-Escrig A, Kulisevsky J, Labrador-Espinosa MA, Lopez-Sendon JL, de Munain Arregui AL, Macias D, Torres IM, Marín J, Marti MJ, Martínez-Castrillo JC, Méndez-Del-Barrio C, González MM, Mata M, Mínguez A, Mir P, Rezola EM, Muñoz E, Pagonabarraga J, Pastor P, Errazquin FP, Periñán-Tocino T, Ruiz-Martínez J, Ruz C, Rodriguez AS, Sierra M, Suarez-Sanmartin E, Tabernero C, Tartari JP, Tejera-Parrado C, Tolosa E, Valldeoriola F, Vargas-González L, Vela L, Vives F, Zimprich A, Pihlstrom L, Toft M, Taba P, Koks S, Hassin-Baer S, Majamaa K, Siitonen A, Tienari P, Okubadejo NU, Ojo OO, Kaiyrzhanov R, Shashkin C, Zharkinbekova N, Akhmetzhanov V, Kaishybayeva G, Karimova A, Khaibullin T, Lynch TL, and International Parkinson's Disease Genomics Consortium (IPDGC)

Abstract

OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Men are on average ~ 1.5 times more likely to develop PD compared to women with European ancestry. Over the years, genomewide association studies (GWAS) have identified numerous genetic risk factors for PD, however, it is unclear whether genetics contribute to disease etiology in a sex-specific manner. METHODS: In an effort to study sex-specific genetic factors associated with PD, we explored 2 large genetic datasets from the International Parkinson's Disease Genomics Consortium and the UK Biobank consisting of 13,020 male PD cases, 7,936 paternal proxy cases, 89,660 male controls, 7,947 female PD cases, 5,473 maternal proxy cases, and 90,662 female controls. We performed GWAS meta-analyses to identify distinct patterns of genetic risk contributing to disease in male versus female PD cases. RESULTS: In total, 19 genomewide significant regions were identified and no sex-specific effects were observed. A high genetic correlation between the male and female PD GWAS were identified (rg = 0.877) and heritability estimates were identical between male and female PD cases (~ 20%). INTERPRETATION: We did not detect any significant genetic differences between male or female PD cases. Our study does not support the notion that common genetic variation on the autosomes could explain the difference in prevalence of PD between males and females cases at least when considering the current sample size under study. Further studies are warranted to investigate the genetic architecture of PD explained by X and Y chromosomes and further evaluate environmental effects that could potentially contribute to PD etiology in male versus female patients. ANN NEUROL 2021;90:41-48.

Published
2021

41. Publisher Correction: Demonstration of reduced neoclassical energy transport in Wendelstein 7-X

Author

Beidler, C. D., Smith, H. M., Alonso, A., Andreeva, T., Baldzuhn, J., Beurskens, M. N. A., Borchardt, M., Bozhenkov, S. A., Brunner, K. J., Damm, H., Drevlak, M., Ford, O. P., Fuchert, G., Geiger, J., Helander, P., Hergenhahn, U., Hirsch, M., H��fel, U., Kazakov, Ye. O., Kleiber, R., Krychowiak, M., Kwak, S., Langenberg, A., Laqua, H. P., Neuner, U., Pablant, N. A., Pasch, E., Pavone, A., Pedersen, T. S., Rahbarnia, K., Schilling, J., Scott, E. R., Stange, T., Svensson, J., Thomsen, H., Turkin, Y., Warmer, F., Wolf, R. C., Zhang, D., Abramovic, I., ��k��slompolo, S., Alcus��n, J., Aleynikov, P., Aleynikova, K., Ali, A., Anda, G., Ascasibar, E., B��hner, J. P., Baek, S. G., Balden, M., Banduch, M., Barbui, T., Behr, W., Benndorf, A., Biedermann, C., Biel, W., Blackwell, B., Blanco, E., Blatzheim, M., Ballinger, S., Bluhm, T., B��ckenhoff, D., B��swirth, B., B��ttger, L.-G., Borsuk, V., Boscary, J., Bosch, H.-S., Brakel, R., Brand, H., Brandt, C., Br��uer, T., Braune, H., Brezinsek, S., Brunner, K.-J., Burhenn, R., Bussiahn, R., Buttensch��n, B., Bykov, V., Cai, J., Calvo, I., Cannas, B., Cappa, A., Carls, A., Carraro, L., Carvalho, B., Castejon, F., Charl, A., Chaudhary, N., Chauvin, D., Chernyshev, F., Cianciosa, M., Citarella, R., Claps, G., Coenen, J., Cole, M., Cole, M. J., Cordella, F., Cseh, G., Czarnecka, A., Czerski, K., Czerwinski, M., Czymek, G., Da Molin, A., Da Silva, A., De La Pena, A., Degenkolbe, S., Dhard, C. P., Dibon, M., Dinklage, A., Dittmar, T., Drewelow, P., Drews, P., Durodie, F., Edlund, E., Effenberg, F., Ehrke, G., Elgeti, S., Endler, M., Ennis, D., Esteban, H., Estrada, T., Fellinger, J., Feng, Y., Flom, E., Fernandes, H., Fietz, W. H., Figacz, W., Fontdecaba, J., Fornal, T., Frerichs, H., Freund, A., Funaba, T., Galkowski, A., Gantenbein, G., Gao, Y., Garc��a Rega��a, J., Gates, D., Geiger, B., Giannella, V., Gogoleva, A., Goncalves, B., Goriaev, A., Gradic, D., Grahl, M., Green, J., Greuner, H., Grosman, A., Grote, H., Gruca, M., Grulke, O., Guerard, C., Hacker, P., Han, X., Harris, J. H., Hartmann, D., Hathiramani, D., Hein, B., Heinemann, B., Henneberg, S., Henkel, M., Hernandez Sanchez, J., Hidalgo, C., Hollfeld, K. P., H��lting, A., H��schen, D., Houry, M., Howard, J., Huang, X., Huang, Z., Hubeny, M., Huber, M., Hunger, H., Ida, K., Ilkei, T., Illy, S., Israeli, B., Jablonski, S., Jakubowski, M., Jelonnek, J., Jenzsch, H., Jesche, T., Jia, M., Junghanns, P., Kacmarczyk, J., Kallmeyer, J.-P., Kamionka, U., Kasahara, H., Kasparek, W., Kenmochi, N., Killer, C., Kirschner, A., Klinger, T., Knauer, J., Knaup, M., Knieps, A., Kobarg, T., Kocsis, G., K��chl, F., Kolesnichenko, Y., K��nies, A., K��nig, R., Kornejew, P., Koschinsky, J.-P., K��ster, F., Kr��mer, M., Krampitz, R., Kr��mer-Flecken, A., Krawczyk, N., Kremeyer, T., Krom, J., Ksiazek, I., Kubkowska, M., K��hner, G., Kurki-Suonio, T., Kurz, P. A., Landreman, M., Lang, P., Lang, R., Langish, S., Laqua, H., Laube, R., Lazerson, S., Lechte, C., Lennartz, M., Leonhardt, W., Li, C., Li, Y., Liang, Y., Linsmeier, C., Liu, S., Lobsien, J.-F., Loesser, D., Loizu Cisquella, J., Lore, J., Lorenz, A., Losert, M., L��cke, A., Lumsdaine, A., Lutsenko, V., Maa��berg, H., Marchuk, O., Matthew, J. H., Marsen, S., Marushchenko, M., Masuzaki, S., Maurer, D., Mayer, M., McCarthy, K., McNeely, P., Meier, A., Mellein, D., Mendelevitch, B., Mertens, P., Mikkelsen, D., Mishchenko, A., Missal, B., Mittelstaedt, J., Mizuuchi, T., Mollen, A., Moncada, V., M��nnich, T., Morisaki, T., Moseev, D., Murakami, S., N��fr��di, G., Nagel, M., Naujoks, D., Neilson, H., Neu, R., Neubauer, O., Ngo, T., Nicolai, D., Nielsen, S. K., Niemann, H., Nishizawa, T., Nocentini, R., N��hrenberg, C., N��hrenberg, J., Obermayer, S., Offermanns, G., Ogawa, K., ��lmanns, J., Ongena, J., Oosterbeek, J. W., Orozco, G., Otte, M., Pacios Rodriguez, L., Panadero, N., Panadero Alvarez, N., Papenfu��, D., Paqay, S., Pawelec, E., Pelka, G., Perseo, V., Peterson, B., Pilopp, D., Pingel, S., Pisano, F., Plaum, B., Plunk, G., P��l��skei, P., Porkolab, M., Proll, J., Puiatti, M.-E., Puig Sitjes, A., Purps, F., Rack, M., R��csei, S., Reiman, A., Reimold, F., Reiter, D., Remppel, F., Renard, S., Riedl, R., Riemann, J., Risse, K., Rohde, V., R��hlinger, H., Rom��, M., Rondeshagen, D., Rong, P., Roth, B., Rudischhauser, L., Rummel, K., Rummel, T., Runov, A., Rust, N., Ryc, L., Ryosuke, S., Sakamoto, R., Salewski, M., Samartsev, A., S��nchez, E., Sano, F., Satake, S., Schacht, J., Satheeswaran, G., Schauer, F., Scherer, T., Schlaich, A., Schlisio, G., Schluck, F., Schl��ter, K.-H., Schmitt, J., Schmitz, H., Schmitz, O., Schmuck, S., Schneider, M., Schneider, W., Scholz, P., Schrittwieser, R., Schr��der, M., Schr��der, T., Schroeder, R., Schumacher, H., Schweer, B., Sereda, S., Shanahan, B., Sibilia, M., Sinha, P., Sipli��, S., Slaby, C., Sleczka, M., Spiess, W., Spong, D. A., Spring, A., Stadler, R., Stejner, M., Stephey, L., Stridde, U., Suzuki, C., Szab��, V., Szabolics, T., Szepesi, T., Sz��kefalvi-Nagy, Z., Tamura, N., Tancetti, A., Terry, J., Thomas, J., Thumm, M., Travere, J. M., Traverso, P., Tretter, J., Trimino Mora, H., Tsuchiya, H., Tsujimura, T., Tulip��n, S., Unterberg, B., Vakulchyk, I., Valet, S., Van��, L., Van Eeten, P., Van Milligen, B., Van Vuuren, A. J., Vela, L., Velasco, J.-L., Vergote, M., Vervier, M., Vianello, N., Viebke, H., Vilbrandt, R., Von Stechow, A., Vork��per, A., Wadle, S., Wagner, F., Wang, E., Wang, N., Wang, Z., Wauters, T., Wegener, L., Weggen, J., Wegner, T., Wei, Y., Weir, G., Wendorf, J., Wenzel, U., Werner, A., White, A., Wiegel, B., Wilde, F., Windisch, T., Winkler, M., Winter, A., Winters, V., Wolf, S., Wright, A., Wurden, G., Xanthopoulos, P., Yamada, H., Yamada, I., Yasuhara, R., Yokoyama, M., Zanini, M., Zarnstorff, M., Zeitler, A., Zhang, H., Zhu, J., Zilker, M., Zocco, A., Zoletnik, S., and Zuin, M.

Subjects
Chemical engineering, ddc:660
Published
2021

42. Mood in Parkinson's disease: From early- to late-stage disease

Author

Santos-Garcia D, De Deus F, Cores B, Valdes A, Suarez C, Aneiros A, Jesus S, Aguilar M, Pastor P, Planellas L, Cosgaya M, Garcia C, Caballol N, Legarda I, Hernandez V, Cabo I, Lopez M, Gonzalez A, Avila R, Jose C, Nogueira V, Puente V, Garcia M, Borrue C, Solano V, Alvarez S, Vela L, Escalante S, Cubo E, Carrillo P, Martinez C, Sanchez A, Alonso L, Lopez A, Gaston I, Kulisevsky J, Blazquez E, Seijo M, Ruiz M, Valero C, Kurtis M, de Fabregues-Boixar O, Prieto J, Lopez D, McAfee D, Mir P, and COPPADIS Study Grp

Subjects
s disease, quality of life, mood, depression, disease duration, Parkinson&apos, Parkinson's disease
Abstract

BACKGROUND: Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. METHODS: PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined

Published
2021

43. Diplopia Is Frequent and Associated with Motor and Non-Motor Severity in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up

Author

Garcia D, Rios L, Fonticoba T, Bartolome C, Roca L, Painceiras M, Miro C, Canfield H, Jesus S, Aguilar M, Pastor P, Cosgaya M, Caldentey J, Caballol N, Legarda I, Vara J, Cabo I, Manzanares L, Aramburu I, Rivera M, Mayordomo V, Nogueira V, Puente V, Dotor J, Borrue C, Vila B, Sauco M, Vela L, Escalante S, Cubo E, Padilla F, Castrillo J, Alonso P, Losada M, Ariztegui N, Gaston I, Kulisevsky J, Estrada M, Seijo M, Martinez J, Valero C, Kurtis M, de Fabregues O, Ardura J, Redondo R, Ordas C, Diaz L, McAfee D, Martinez-Martin P, Mir P, COPPADIS Study Grp, Instituto de Salud Carlos III, Takeda Pharmaceutical Company, International Parkinson and Movement Disorder Society, AbbVie Pharmaceuticals, Abbott Laboratories, Allergan Foundation, BIAL Foundation, Merz Pharma, UCB Pharma, Zambon, Ministerio de Economía y Competitividad (España), European Commission, Junta de Andalucía, Sociedad Andaluza de Neurología, Jacques and Gloria Gossweiler Foundation, Fundación Alicia Koplowitz, Fundación Mutua Madrileña, Institut Català de la Salut, [Santos-García D, Naya Rios L, Cores Bartolomé C, García Roca L, Feal Painceiras M, Martínez Miró C] Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain. [de Deus Fonticoba T, Canfield H] Complejo Hospitalario Universitario de Ferrol (CHUF), A Coruña, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Aguilar M, Pastor P] Hospital Universitari Mutua de Terrassa, Terrassa , Spain. [Cosgaya M] Hospital Clínic de Barcelona, Barcelona, Spain. [García-Caldentey J] Centro Neurológico Oms, Palma de Mallorca, Spain. [Caballol N] Consorci Sanitari Integral, Hospital Moisés Broggi, Barcelona, Spain. [Legarda I] Hospital Universitari Son Espases, Palma de Mallorca, Spain. [Hernández-Vara J, de Fábregues O] Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Cabo López I, Seijo M] Complexo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. [López Manzanares L] Hospital Universitario La Princesa, Madrid, Spain. [González Aramburu I] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Ávila Rivera MA] Consorci Sanitari Integral, Hospital General de L'Hospitalet, L'Hospitalet de Llobregat, Spain. [Gómez-Mayordomo V] Hospital Universitario Clínico San Carlos, Madrid, Spain. [Nogueira V] Hospital Da Costa, Burela, Lugo, Spain. [Puente V] Hospital del Mar, Barcelona, Spain. [Dotor J] Hospital Universitario Virgen Macarena, Sevilla, Spain. [Borrué C] Hospital Infanta Sofía, Madrid, Spain. [Solano Vila B] Institut d'Assistència Sanitària (IAS), Institut Català de la Salut (ICS), Salt, Spain. [Álvarez Sauco M] Hospital General Universitario de Elche, Elche, Spain. [Vela-Desojo L] Fundación Hospital de Alcorcón, Madrid, Spain. [Escalante S] Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Spain. [Cubo E] Complejo Asistencial Universitario de Burgos, Burgos, Spain. [Carrillo-Padilla F] Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Martínez Castrillo JC] Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain. [Sánchez Alonso P] Hospital Universitario Puerta de Hierro, Madrid, Spain. [Alonso Losada MG] Hospital Álvaro Cunqueiro, Complexo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain. [López-Ariztegui N] Complejo Hospitalario de Toledo, Toledo, Spain. [Gastón I] Complejo Hospitalario de Navarra, Pamplona, Spain. [Kulisevsky J] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Hospital de Sant Pau, Barcelona, Spain. [Blázquez Estrada M] Hospital Universitario Central de Asturias, Oviedo, Spain. [Ruiz-Martínez J] Hospital Universitario Donostia, San Sebastián, Spain. [Valero C] Hospital Arnau de Vilanova, València, Spain. [Kurtis M] Hospital Ruber Internacional, Madrid, Spain. [González Ardura J] Hospital de Cabueñes, Gijón, Spain. [Alonso Redondo R] Universitario Lucus Augusti (HULA), Lugo, Spain. [Ordás C] Hospital Rey Juan Carlos, Madrid, Spain. [López Díaz LM] Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain. [McAfee D] University of Maryland School of Medicine, Baltimore, USA. [Martinez-Martin P] Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain, and Institut d'Assistència Sanitària

Subjects
enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::trastornos del movimiento::trastornos parkinsonianos::enfermedades del sistema nervioso::enfermedad de Parkinson [ENFERMEDADES], Medicine (General), changes, motor, Parkinson’s disease, phenotype, PIGD, Tremor, endocrine system diseases, genetic structures, Parkinson's disease, Clinical Biochemistry, Tremolor, Nervous System Diseases::Central Nervous System Diseases::Nervous System Diseases::Central Nervous System Diseases::Movement Disorders::Parkinsonian Disorders::Nervous System Diseases::Parkinson Disease [DISEASES], enfermedades del sistema nervioso::manifestaciones neurológicas::discinesias::temblor [ENFERMEDADES], Article, eye diseases, Fenotip, R5-920, Genetic Phenomena::Phenotype [PHENOMENA AND PROCESSES], Parkinson, Malaltia de, fenómenos genéticos::fenotipo [FENÓMENOS Y PROCESOS], Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Tremor [DISEASES]
Abstract

[Background and objective] Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it., [Patients and Methods] PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls., [Results] The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716)., [Conclusions] Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity., Martínez-Martin P. has received honoraria from National School of Public Health (ISCIII), Editori-al Viguera and Takeda Pharmaceuticals for lecturing in courses, and from the International Parkinson and Movement Disorder Society (MDS) for management of the Program on Rating Scales. Mir P. has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB, and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575], co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [ PI-0437-2012, PI-0471-2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, the Fundación Mutua Madrileña.

Published
2021

44. Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life

Author

Santos García, Diego, De Deus Fonticoba, T., Paz González, J. M., Cores Bartolomé, C., Valdés Aymerich, L., Muñoz Enríquez, J. G., Suárez, E., Jesús, S., Aguilar, M., Pastor, P., Planellas, L. L., Cosgaya, M., García Caldentey, J., Caballol, N., Legarda, I., Hernández-Vara, Jorge, Cabo, I., López Manzanares, L., González Aramburu, I., Ávila Rivera, M. A., Catalán, M. J., Nogueira, V., Puente, V., García Moreno, José Manuel, Borrué, C., Solano Vila, B., Álvarez Sauco, M., Vela, L., Escalante, S., Cubo, E., Carrillo Padilla, F., Martínez Castrillo, J. C., Sánchez Alonso, P., Alonso Losada, M. G., López Ariztegui, N., Gastón, I., Kulisevsky, Jaime, Blázquez Estrada, M., Seijo, M., Rúiz Martínez, J., Valero, C., Kurtis, M., de Fábregues, Oriol, González Ardura, J., Ordás, C., López Díaz, L., Mir, P., Martinez-Martin, Pablo, COPPADIS Study Group, None, Universitat Autònoma de Barcelona, Santos García, Diego, De Deus Fonticoba, T., Paz González, J. M., Cores Bartolomé, C., Valdés Aymerich, L., Muñoz Enríquez, J. G., Suárez, E., Jesús, S., Aguilar, M., Pastor, P., Planellas, L. L., Cosgaya, M., García Caldentey, J., Caballol, N., Legarda, I., Hernández-Vara, Jorge, Cabo, I., López Manzanares, L., González Aramburu, I., Ávila Rivera, M. A., Catalán, M. J., Nogueira, V., Puente, V., García Moreno, José Manuel, Borrué, C., Solano Vila, B., Álvarez Sauco, M., Vela, L., Escalante, S., Cubo, E., Carrillo Padilla, F., Martínez Castrillo, J. C., Sánchez Alonso, P., Alonso Losada, M. G., López Ariztegui, N., Gastón, I., Kulisevsky, Jaime, Blázquez Estrada, M., Seijo, M., Rúiz Martínez, J., Valero, C., Kurtis, M., de Fábregues, Oriol, González Ardura, J., Ordás, C., López Díaz, L., Mir, P., Martinez-Martin, Pablo, COPPADIS Study Group, None, and Universitat Autònoma de Barcelona

Abstract

Altres ajuts: Fundació La Marató De TV3, In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [ n = 15] vs 2A [ n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.

Published
2021

45. Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Author

Storm, C.S., Kia, D.A., Almramhi, M.M., Bandrés-Ciga, S., Finan, C., Noyce, A.J., Kaiyrzhanov, R., Middlehurst, B., Tan, M., Houlden, H., Morris, H.R., Plun-Favreau, H., Holmans, P., Hardy, J., Trabzuni, D., Quinn, J., Bubb, V., Mok, K.Y., Kinghorn, K.J., Lewis, P., Schreglmann, S.R., Lovering, R., R’Bibo, L., Manzoni, C., Rizig, M., Ryten, M., Guelfi, S., Escott-Price, V., Chelban, V., Foltynie, T., Williams, N., Morrison, K.E., Clarke, C., Harvey, K., Jacobs, B.M., Brice, A., Danjou, F., Lesage, S., Corvol, J-C, Martinez, M., Schulte, C., Brockmann, K., Simón-Sánchez, J., Heutink, P., Rizzu, P., Sharma, M., Gasser, T., Schneider, S.A., Cookson, M.R., Blauwendraat, C., Craig, D.W., Billingsley, K., Makarious, M.B., Narendra, D.P., Faghri, F., Gibbs, J.R., Hernandez, D.G., Van Keuren-Jensen, K., Shulman, J.M., Iwaki, H., Leonard, H.L., Nalls, M.A., Robak, L., Bras, J., Guerreiro, R., Lubbe, S., Troycoco, T., Finkbeiner, S., Mencacci, N.E., Lungu, C., Singleton, A.B., Scholz, S.W., Reed, X., Uitti, R.J., Ross, O.A., Grenn, F.P., Moore, A., Alcalay, R.N., Wszolek, Z.K., Gan-Or, Z., Rouleau, G.A., Krohn, L., Mufti, K., van Hilten, J.J., Marinus, J., Adarmes-Gómez, A.D., Aguilar, M., Alvarez, I., Alvarez, V., Barrero, F.J., Yarza, J.A.B., Bernal-Bernal, I., Blazquez, M., Bonilla-Toribio, M., Botía, J.A., Boungiorno, M.T., Buiza-Rueda, D., Cámara, A., Carrillo, F., Carrión-Claro, M., Cerdan, D., Clarimón, J., Compta, Y., Diez-Fairen, M., Dols-Icardo, O., Duarte, J., Duran, R., Escamilla-Sevilla, F., Ezquerra, M., Feliz, C., Fernández, M., Fernández-Santiago, R., Garcia, C., García-Ruiz, P., Gómez-Garre, P., Heredia, M.J.G., Gonzalez-Aramburu, I., Pagola, A.G., Hoenicka, J., Infante, J., Jesús, S., Jimenez-Escrig, A., Kulisevsky, J., Labrador-Espinosa, M.A., Lopez-Sendon, J.L., de Munain Arregui, A.L., Macias, D., Torres, I.M., Marín, J., Marti, M.J., Martínez-Castrillo, J.C., Méndez-del-Barrio, C., González, M.M., Mata, M., Mínguez, A., Mir, P., Rezola, E.M., Muñoz, E., Pagonabarraga, J., Pastor, P., Errazquin, F.P., Periñán-Tocino, T., Ruiz-Martínez, J., Ruz, C., Rodriguez, A.S., Sierra, M., Suarez-Sanmartin, E., Tabernero, C., Tartari, J.P., Tejera-Parrado, C., Tolosa, E., Valldeoriola, F., Vargas-González, L., Vela, L., Vives, F., Zimprich, A., Pihlstrom, L., Toft, M., Taba, P., Kõks, S., Hassin-Baer, S., Majamaa, K., Siitonen, A., Tienari, P., Okubadejo, N.U., Ojo, O.O., Shashkin, C., Zharkinbekova, N., Akhmetzhanov, V., Kaishybayeva, G., Karimova, A., Khaibullin, T., Lynch, T.L., Hingorani, A.D., Wood, N.W., Storm, C.S., Kia, D.A., Almramhi, M.M., Bandrés-Ciga, S., Finan, C., Noyce, A.J., Kaiyrzhanov, R., Middlehurst, B., Tan, M., Houlden, H., Morris, H.R., Plun-Favreau, H., Holmans, P., Hardy, J., Trabzuni, D., Quinn, J., Bubb, V., Mok, K.Y., Kinghorn, K.J., Lewis, P., Schreglmann, S.R., Lovering, R., R’Bibo, L., Manzoni, C., Rizig, M., Ryten, M., Guelfi, S., Escott-Price, V., Chelban, V., Foltynie, T., Williams, N., Morrison, K.E., Clarke, C., Harvey, K., Jacobs, B.M., Brice, A., Danjou, F., Lesage, S., Corvol, J-C, Martinez, M., Schulte, C., Brockmann, K., Simón-Sánchez, J., Heutink, P., Rizzu, P., Sharma, M., Gasser, T., Schneider, S.A., Cookson, M.R., Blauwendraat, C., Craig, D.W., Billingsley, K., Makarious, M.B., Narendra, D.P., Faghri, F., Gibbs, J.R., Hernandez, D.G., Van Keuren-Jensen, K., Shulman, J.M., Iwaki, H., Leonard, H.L., Nalls, M.A., Robak, L., Bras, J., Guerreiro, R., Lubbe, S., Troycoco, T., Finkbeiner, S., Mencacci, N.E., Lungu, C., Singleton, A.B., Scholz, S.W., Reed, X., Uitti, R.J., Ross, O.A., Grenn, F.P., Moore, A., Alcalay, R.N., Wszolek, Z.K., Gan-Or, Z., Rouleau, G.A., Krohn, L., Mufti, K., van Hilten, J.J., Marinus, J., Adarmes-Gómez, A.D., Aguilar, M., Alvarez, I., Alvarez, V., Barrero, F.J., Yarza, J.A.B., Bernal-Bernal, I., Blazquez, M., Bonilla-Toribio, M., Botía, J.A., Boungiorno, M.T., Buiza-Rueda, D., Cámara, A., Carrillo, F., Carrión-Claro, M., Cerdan, D., Clarimón, J., Compta, Y., Diez-Fairen, M., Dols-Icardo, O., Duarte, J., Duran, R., Escamilla-Sevilla, F., Ezquerra, M., Feliz, C., Fernández, M., Fernández-Santiago, R., Garcia, C., García-Ruiz, P., Gómez-Garre, P., Heredia, M.J.G., Gonzalez-Aramburu, I., Pagola, A.G., Hoenicka, J., Infante, J., Jesús, S., Jimenez-Escrig, A., Kulisevsky, J., Labrador-Espinosa, M.A., Lopez-Sendon, J.L., de Munain Arregui, A.L., Macias, D., Torres, I.M., Marín, J., Marti, M.J., Martínez-Castrillo, J.C., Méndez-del-Barrio, C., González, M.M., Mata, M., Mínguez, A., Mir, P., Rezola, E.M., Muñoz, E., Pagonabarraga, J., Pastor, P., Errazquin, F.P., Periñán-Tocino, T., Ruiz-Martínez, J., Ruz, C., Rodriguez, A.S., Sierra, M., Suarez-Sanmartin, E., Tabernero, C., Tartari, J.P., Tejera-Parrado, C., Tolosa, E., Valldeoriola, F., Vargas-González, L., Vela, L., Vives, F., Zimprich, A., Pihlstrom, L., Toft, M., Taba, P., Kõks, S., Hassin-Baer, S., Majamaa, K., Siitonen, A., Tienari, P., Okubadejo, N.U., Ojo, O.O., Shashkin, C., Zharkinbekova, N., Akhmetzhanov, V., Kaishybayeva, G., Karimova, A., Khaibullin, T., Lynch, T.L., Hingorani, A.D., and Wood, N.W.

Abstract

Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their efficacy as drug targets for Parkinson’s disease. We use expression and protein quantitative trait loci to mimic exposure to medications, and we examine the causal effect on Parkinson’s disease risk (in two large cohorts), age at onset and progression. We propose 23 drug-targeting mechanisms for Parkinson’s disease, including four possible drug repurposing opportunities and two drugs which may increase Parkinson’s disease risk. Of these, we put forward six drug targets with the strongest Mendelian randomization evidence. There is remarkably little overlap between our drug targets to reduce Parkinson’s disease risk versus progression, suggesting different molecular mechanisms. Drugs with genetic support are considerably more likely to succeed in clinical trials, and we provide compelling genetic evidence and an analysis pipeline to prioritise Parkinson’s disease drug development.

Published
2021

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