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5. Other Ixodes-Borne Diseases

Author

Boyer, Pierre H., Grillon, Antoine, Jaulhac, Benoît, Velay, Aurélie, Schramm, Frédéric, Talagrand-Reboul, Emilie, Hunfeld, Klaus-Peter, editor, and Gray, Jeremy, editor

Published
2022
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6. Tick-Borne Encephalitis in Pregnant Woman and Long-Term Sequelae

Author

Velay, Aurelie, Janssen-Langenstein, Ralf, Kremer, Stephane, Laugel, Elodie, Lutz, Maximilian, Pierson, Anne Laure, Wendling, Marie-Josee, Schneider, Francis, and Fafi-Kremer, Samira

Subjects
Pregnant women -- Case studies -- Care and treatment, Tick-borne encephalitis -- Case studies -- Care and treatment -- Complications and side effects, Health
Abstract

Tick-borne encephalitis (TBE), an emerging infectious disease, has shown a deeply evolving epidemiology during the past decade, especially in Europe (1). TBE virus (TBEV) is transmitted mainly to humans by [...]

Published
2023
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7. COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France

Author

Velay, Aurélie, Gallais, Floriane, Wendling, Marie-Josée, Bayer, Sophie, Reix, Nathalie, Schneider, Anne, Glady, Ludovic, Collongues, Nicolas, Lessinger, Jean-Marc, Hansmann, Yves, Kling-Pillitteri, Laurence, De Sèze, Jérome, Gonzalez, Maria, Schmidt-Mutter, Catherine, Meyer, Nicolas, and Fafi-Kremer, Samira

Published
2022
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8. Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection

Author

Gallais, Floriane, Gantner, Pierre, Bruel, Timothée, Velay, Aurélie, Planas, Delphine, Wendling, Marie-Josée, Bayer, Sophie, Solis, Morgane, Laugel, Elodie, Reix, Nathalie, Schneider, Anne, Glady, Ludovic, Panaget, Baptiste, Collongues, Nicolas, Partisani, Marialuisa, Lessinger, Jean-Marc, Fontanet, Arnaud, Rey, David, Hansmann, Yves, Kling-Pillitteri, Laurence, Schwartz, Olivier, De Sèze, Jérome, Meyer, Nicolas, Gonzalez, Maria, Schmidt-Mutter, Catherine, and Fafi-Kremer, Samira

Published
2021
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9. Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France

Author

Fafi-Kremer, Samira, Bruel, Timothée, Madec, Yoann, Grant, Rebecca, Tondeur, Laura, Grzelak, Ludivine, Staropoli, Isabelle, Anna, François, Souque, Philippe, Fernandes-Pellerin, Sandrine, Jolly, Nathalie, Renaudat, Charlotte, Ungeheuer, Marie-Noëlle, Schmidt-Mutter, Catherine, Collongues, Nicolas, Bolle, Alexandre, Velay, Aurélie, Lefebvre, Nicolas, Mielcarek, Marie, Meyer, Nicolas, Rey, David, Charneau, Pierre, Hoen, Bruno, De Seze, Jérôme, Schwartz, Olivier, and Fontanet, Arnaud

Published
2020
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10. Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Author

Gallais, Floriane, Velay, Aurelie, Nazon, Charlotte, Wendling, Marie-Josee, Partisani, Marialuisa, Sibilia, Jean, Candon, Sophie, and Fafi-Kremer, Samira

Subjects
Epidemics -- Physiological aspects -- France, Immune response -- Testing, Disease transmission -- Observations, Host-virus relationships, Health
Abstract

Coronavirus disease (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic that raises a major concern all around the world (1). To contain the [...]

Published
2021
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14. Tick-Borne Encephalitis in Auvergne-Rhone-Alpes Region, France, 2017-2018

Author

Botelho-Nevers, Elisabeth, Gagneux-Brunon, Amandine, Velay, Aurelie, Guerbois- Galla, Mathilde, Grard, Gilda, Bretagne, Claire, Mailles, Alexandra, Verhoeven, Paul O., Pozzetto, Bruno, Gonzalo, Sylvie, Fafi-Kremer, Samira, Leparc-Goffart, Isabelle, and Pillet, Sylvie

Subjects
Tick-borne encephalitis -- Health aspects, Disease transmission -- Health aspects, Zoonoses -- Health aspects, Rural areas, Encephalitis, Borrelia infections, Infection, Tick-borne diseases, Health
Abstract

Tick-borne encephalitis (TBE) is a zoonotic disease caused by tick-borne encephalitis virus (TBEV), a flavivirus transmitted to humans by the bite of an infected tick (1) and usually acquired during [...]

Published
2019
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15. A new hot spot for tick-borne encephalitis (TBE): A marked increase of TBE cases in France in 2016

Author

Velay, Aurélie, Solis, Morgane, Kack-Kack, Wallys, Gantner, Pierre, Maquart, Marianne, Martinot, Martin, Augereau, Olivier, De Briel, Dominique, Kieffer, Pierre, Lohmann, Caroline, Poveda, Jean Dominique, Cart-Tanneur, Emmanuelle, Argemi, Xavier, Leparc-Goffart, Isabelle, de Martino, Sylvie, Jaulhac, Benoit, Raguet, Sophie, Wendling, Marie-Josée, Hansmann, Yves, and Fafi-Kremer, Samira

Published
2018
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16. Seroprevalence for Borrelia burgdorferi sensu lato and tick-borne encephalitis virus antibodies and associated risk factors among forestry workers in northern France, 2019 to 2020

Author

Septfons, Alexandra, primary, Rigaud, Emma, additional, Bénézet, Laetitia, additional, Velay, Aurelie, additional, Zilliox, Laurence, additional, Baldinger, Lisa, additional, Gonzalez, Gaëlle, additional, Figoni, Julie, additional, de Valk, Henriette, additional, Deffontaines, Gaëtan, additional, Desenclos, Jean Claude, additional, and Jaulhac, Benoit, additional

Published
2023
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22. Hepatitis C Virus Envelope Glycoprotein Signatures Are Associated With Treatment Failure and Modulation of Viral Entry and Neutralization

Author

Schvoerer, Evelyne, Moenne-Loccoz, Rémy, Murray, John M., Velay, Aurélie, Turek, Marine, Fofana, Isabel, Fafi-Kremer, Samira, Erba, Anne-Claire, Habersetzer, François, Doffoël, Michel, Gut, Jean-Pierre, Donlin, Maureen J., Tavis, John E., Zeisel, Mirjam B., Stoll-Keller, Françoise, and Baumert, Thomas F.

Published
2013
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23. Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection

Author

Pelleau, Stéphane, Woudenberg, Tom, Rosado, Jason, Donnadieu, Françoise, Garcia, Laura, Obadia, Thomas, Gardais, Soazic, Elgharbawy, Yasmine, Velay, Aurelie, Gonzalez, Maria, Nizou, Jacques Yves, Khelil, Nizar, Zannis, Konstantinos, Cockram, Charlotte, Merkling, Sarah Hélène, Meola, Annalisa, Kerneis, Solen, Terrier, Benjamin, de Seze, Jerome, Planas, Delphine, Schwartz, Olivier, Dejardin, François, Petres, Stéphane, von Platen, Cassandre, Pellerin, Sandrine Fernandes, Arowas, Laurence, de Facci, Louise Perrin, Duffy, Darragh, Cheallaigh, Clíona Ní, Dunne, Jean, Conlon, Niall, Townsend, Liam, Duong, Veasna, Auerswald, Heidi, Pinaud, Laurie, Tondeur, Laura, Backovic, Marija, Hoen, Bruno, Fontanet, Arnaud, Mueller, Ivo, Fafi-Kremer, Samira, Bruel, Timothée, White, Michael, Epidémiologie et Analyse des Maladies Infectieuses - Infectious Disease Epidemiology and Analytics, Institut Pasteur [Paris] (IP), Malaria : parasites et hôtes - Malaria : parasites and hosts, Santé publique : épidémiologie & sciences de l'information biomédicale (ED 393), Sorbonne Université (SU), Département de Biologie Computationnelle - Department of Computational Biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Strasbourg, Institut Mutualiste de Montsouris (IMM), Régulation spatiale des Génomes - Spatial Regulation of Genomes, Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Virologie Structurale - Structural Virology, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Université de Paris, Paris, France, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Virus et Immunité - Virus and immunity (CNRS-UMR3569), Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform (PPR), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Immunologie Translationnelle - Translational Immunology lab, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Trinity College Dublin, Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Direction de la recherche médicale de l'Institut Pasteur, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), The Walter and Eliza Hall Institute of Medical Research (WEHI), University of Melbourne, Vaccine Research Institute [Créteil, France] (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), This work was supported by the European Research Council (MultiSeroSurv ERC Starting Grant 852373, MW), l’Agence Nationale de la Recherche and Fondation pour la Recherche Médicale (CorPopImm, MW), and the Institut Pasteur International Network (CoronaSeroSurv, MW). JR was supported by the Pasteur Paris University (PPU) International PhD Program. CC was supported by the European Research Council 771813. MB, AL and HA were supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur. HA is supported by Centre for International Migration and Development. NC and CNC are part-funded by a Science Foundation Ireland (SFI) grant, Grant Code 20/SPP/3685. LT has been awarded the Irish ClinicalAcademic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z), the Health Service Executive, National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland (https://icatprogramme.org/). MB and AM were supported by Institut Pasteur TaskForce funding (TooLab project). IM is supported by a NHMRC Principal Research Fellowship. SFK lab is funded by Strasbourg University Hospitals (SeroCoV-HUS, PRI 7782), the Agence Nationale de la Recherche (ANR-18-CE17-0028), Laboratoire d'Excellence TRANSPLANTEX (ANR-11-LABX-0070_TRANSPLANTEX), and Institut National de la Santé et de la Recherche Médicale (UMR_S1109)., ANR-20-COVI-0052,CorPopImm,Évaluer l'immunité contre SARS-CoV-2 à l'échelle de la population grâce aux tests sérologiques(2020), ANR-18-CE17-0028,HuMABK,Les anticorps monoclonaux humains : une Nouvelle approche thérapeutique contre l'infection par le virus BK et les maladies associées(2018), ANR-11-LABX-0070,TRANSPLANTEX,Nouveaux loci d'histocompatibilité/biomarqueurs en transplantation humaine: de la découverte à l'app(2011), European Project: 852373,ERC-2019-STG,MultiSeroSurv(2020), European Project: 771813,ERC-2017-COG,SynarchiC(2018), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Virus et Immunité - Virus and immunity, Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM), HESAM Université (HESAM), Vaccine Research Institute (VRI), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)

Subjects
Male, Aucun, Antibodies, Viral, time since infection, MESH: Aged, 80 and over, Antibody Specificity, Seroepidemiologic Studies, MESH: COVID-19, Aged, 80 and over, MESH: Immunoglobulin G, MESH: Aged, MESH: Middle Aged, seroprevalence, MESH: Kinetics, Middle Aged, MESH: Antibody Formation, AcademicSubjects/MED00290, MESH: Young Adult, surveillance, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, France, Adult, antibody kinetics, Adolescent, SARS-SoV-2, Sensitivity and Specificity, Young Adult, Major Article, Humans, Serologic Tests, MESH: SARS-CoV-2, MESH: Antibody Specificity, Aged, MESH: Adolescent, MESH: Humans, MESH: Seroepidemiologic Studies, SARS-CoV-2, MESH: Serologic Tests, COVID-19, MESH: Adult, MESH: Male, MESH: Sensitivity and Specificity, MESH: France, Kinetics, sero-prevalence, Immunoglobulin G, Antibody Formation, MESH: Female, MESH: Antibodies, Viral
Abstract

Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time. Methods We developed a multiplex serological test for measuring antibodies to 5 SARS-CoV-2 antigens and the spike proteins of seasonal coronaviruses. We measured antibody responses in cohorts of hospitalized patients and healthcare workers followed for up to 11 months after symptoms. A mathematical model of antibody kinetics was used to quantify the duration of antibody responses. Antibody response data were used to train algorithms for estimating time since infection. Results One year after symptoms, we estimate that 36% (95% range, 11%–94%) of anti-Spike immunoglobulin G (IgG) remains, 31% (95% range, 9%–89%) anti-RBD IgG remains, and 7% (1%–31%) of anti-nucleocapsid IgG remains. The multiplex assay classified previous infections into time intervals of 0–3 months, 3–6 months, and 6–12 months. This method was validated using data from a seroprevalence survey in France, demonstrating that historical SARS-CoV-2 transmission can be reconstructed using samples from a single survey. Conclusions In addition to diagnosing previous SARS-CoV-2 infection, multiplex serological assays can estimate the time since infection, which can be used to reconstruct past epidemics., Longitudinal follow-up of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reveals differences in the duration of antibodies to multiple antigens. Mathematical models of antibody waning and statistical algorithms can estimate an individual’s time since SARS-CoV-2 infection, and previous transmission waves in a population.

Published
2021
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27. In-depth virological assessment of kidney transplant recipients with COVID-19

Author

Benotmane, Ilies, Gautier-Vargas, Gabriela, Wendling, Marie-Josée, Perrin, Peggy, Velay, Aurélie, Bassand, Xavier, Bedo, Dimitri, Baldacini, Clément, Sagnard, Mylène, Bozman, Dogan-Firat, Della-Chiesa, Margaux, Solis, Morgane, Gallais, Floriane, Cognard, Noëlle, Olagne, Jérôme, Delagrèverie, Héloïse, Gontard, Louise, Panaget, Baptiste, Marx, David, Heibel, Françoise, Braun-Parvez, Laura, Moulin, Bruno, Caillard, Sophie, and Fafi-Kremer, Samira

Published
2020
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28. Anti-SARS-CoV-2 Antibodies Persist for up to 13 Months and Reduce Risk of Reinfection

Author

Gallais, Floriane, primary, Gantner, Pierre, additional, Bruel, Timothée, additional, Velay, Aurelie, additional, Planas, Delphine, additional, Wendling, Marie-Josée, additional, Bayer, Sophie, additional, Solis, Morgane, additional, Laugel, Elodie, additional, Reix, Nathalie, additional, Schneider, Anne, additional, Glady, Ludovic, additional, Panaget, Baptiste, additional, Collongues, Nicolas, additional, Partisani, Marialuisa, additional, Lessinger, Jean-Marc, additional, Fontanet, Arnaud, additional, Rey, David, additional, Hansmann, Yves, additional, Kling-Pillitteri, Laurence, additional, Schwartz, Olivier, additional, De Sèze, Jérome, additional, Meyer, Nicolas, additional, Gonzalez, Maria, additional, Schmidt-Mutter, Catherine, additional, and Fafi-Kremer, Samira, additional

Published
2021
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29. Serological reconstruction of COVID-19 epidemics through analysis of antibody kinetics to SARS-CoV-2 proteins

Author

Pelleau, Stéphane, primary, Woudenberg, Tom, additional, Rosado, Jason, additional, Donnadieu, Françoise, additional, Garcia, Laura, additional, Obadia, Thomas, additional, Gardais, Soazic, additional, Elgharbawy, Yasmine, additional, Velay, Aurelie, additional, Gonzalez, Maria, additional, Nizou, Jacques Yves, additional, Khelil, Nizar, additional, Zannis, Konstantinos, additional, Cockram, Charlotte, additional, Hélène Merkling, Sarah, additional, Meola, Annalisa, additional, Kerneis, Solen, additional, Terrier, Benjamin, additional, de Seze, Jerome, additional, Planas, Delphine, additional, Schwartz, Olivier, additional, Dejardin, François, additional, Petres, Stéphane, additional, von Platen, Cassandre, additional, Arowas, Laurence, additional, de Facci, Louise Perrin, additional, Duffy, Darragh, additional, Cheallaigh, Clíona Ní, additional, Conlon, Niall, additional, Townsend, Liam, additional, Auerswald, Heidi, additional, Backovic, Marija, additional, Hoen, Bruno, additional, Fontanet, Arnaud, additional, Mueller, Ivo, additional, Fafi-Kremer, Samira, additional, Bruel, Timothée, additional, and White, Michael, additional

Published
2021
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30. Evaluation of the performance of SARS-CoV-2 serological tools and their positioning in COVID-19 diagnostic strategies

Author

Velay, Aurelie, primary, Gallais, Floriane, additional, Benotmane, Ilies, additional, Wendling, Marie Josée, additional, Danion, François, additional, Collange, Olivier, additional, De Sèze, Jérôme, additional, Schmidt-Mutter, Catherine, additional, Schneider, Francis, additional, Bilbault, Pascal, additional, Meziani, Ferhat, additional, and Fafi-Kremer, Samira, additional

Published
2020
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32. Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France

Author

Fafi-Kremer, Samira, primary, Bruel, Timothee, additional, Madec, Yoann, additional, Grant, Rebecca, additional, Tondeur, Laura, additional, Grzelak, Ludivine, additional, Staropoli, Isabelle, additional, Anna, Francois, additional, Souque, Philippe, additional, Mutter, Catherine, additional, Collongues, Nicolas, additional, Bolle, Alexandre, additional, Velay, Aurelie, additional, Lefebvre, Nicolas, additional, Mielcarek, Marie, additional, Meyer, Nicolas, additional, Rey, David, additional, Charneau, Pierre, additional, Hoen, Bruno, additional, De Seze, Jerome, additional, Schwartz, Olivier, additional, and Fontanet, Arnaud, additional

Published
2020
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36. Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.

Author

Pelleau S, Woudenberg T, Rosado J, Donnadieu F, Garcia L, Obadia T, Gardais S, Elgharbawy Y, Velay A, Gonzalez M, Nizou JY, Khelil N, Zannis K, Cockram C, Merkling SH, Meola A, Kerneis S, Terrier B, de Seze J, Planas D, Schwartz O, Dejardin F, Petres S, von Platen C, Pellerin SF, Arowas L, de Facci LP, Duffy D, Cheallaigh CN, Dunne J, Conlon N, Townsend L, Duong V, Auerswald H, Pinaud L, Tondeur L, Backovic M, Hoen B, Fontanet A, Mueller I, Fafi-Kremer S, Bruel T, and White M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Antibody Formation, Antibody Specificity, COVID-19 epidemiology, Female, France epidemiology, Humans, Immunoglobulin G blood, Kinetics, Male, Middle Aged, SARS-CoV-2 immunology, Sensitivity and Specificity, Seroepidemiologic Studies, Young Adult, Antibodies, Viral blood, COVID-19 blood, COVID-19 immunology, Serologic Tests methods
Abstract

Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time., Methods: We developed a multiplex serological test for measuring antibodies to 5 SARS-CoV-2 antigens and the spike proteins of seasonal coronaviruses. We measured antibody responses in cohorts of hospitalized patients and healthcare workers followed for up to 11 months after symptoms. A mathematical model of antibody kinetics was used to quantify the duration of antibody responses. Antibody response data were used to train algorithms for estimating time since infection., Results: One year after symptoms, we estimate that 36% (95% range, 11%-94%) of anti-Spike immunoglobulin G (IgG) remains, 31% (95% range, 9%-89%) anti-RBD IgG remains, and 7% (1%-31%) of anti-nucleocapsid IgG remains. The multiplex assay classified previous infections into time intervals of 0-3 months, 3-6 months, and 6-12 months. This method was validated using data from a seroprevalence survey in France, demonstrating that historical SARS-CoV-2 transmission can be reconstructed using samples from a single survey., Conclusions: In addition to diagnosing previous SARS-CoV-2 infection, multiplex serological assays can estimate the time since infection, which can be used to reconstruct past epidemics., (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)

Published
2021
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