18 results on '"Velayuthaprabhu, S."'
Search Results
2. Anti-diabetic and hypolipidemic effects of Cinnamon cassia bark extracts: an in vitro, in vivo, and in silico approach.
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Vijayakumar, K., Prasanna, B., Rengarajan, R. L., Rathinam, A., Velayuthaprabhu, S., and Vijaya Anand, A.
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CASSIA (Genus) ,BIOACTIVE compounds ,CINNAMON ,ETHANOL ,MOLECULAR docking ,HEXANE - Abstract
The present investigation was aimed to study the anti-diabetic and hypolipidemic potential of Cinnamon cassia (Lauraceae family) bark in streptozotocin (STZ)-induced diabetic rats. The preliminary phytochemical analysis (hexane, petroleum ether, chloroform, ethanol, methanol, and aqueous extracts), GC-MS analysis (ethanol), in vitro (aqueous, ethanol and methanol), in vivo (ethanol) and in silico anti-diabetic activity with hypolipidemic effect of C. cassia bark was analysed. The ethanolic extract of the C. cassia bark has a fine inhibitory activity than the aqueous and methanolic extract. Out of 20 different compounds identified, seven compounds were biologically active, and 9-octadecenoic acid has highly interacted with PPARα/γ in docking studies. The levels of diabetic markers, enzymes, and lipid profiles were altered in STZ-induced rats, but after the treatment of C. cassia, the levels were returned to the normal. The study may prove the ethanolic extract of C. cassia has a powerful anti-diabetic and anti-hyperlipidemic activity. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach
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Sangeetha, T., primary, Ibrahim, K. Syed, additional, Deepa, S., additional, Balamuralikrishnan, B., additional, Arun, M., additional, Velayuthaprabhu, S., additional, Saradhadevi, K. M., additional, and Anand, A. Vijaya, additional
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- 2022
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4. Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats.
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Vijayakumar, K., Rengarajan, R. L., Suganthi, N., Prasanna, B., Velayuthaprabhu, S., Shenbagam, M., and Vijaya Anand, A.
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ACUTE toxicity testing ,STREPTOZOTOCIN ,RATS ,CASSIA (Genus) ,CINNAMON ,ALANINE aminotransferase - Abstract
The medicinal properties of Cinnamon cassia (C. cassia) bark have been reported for their clinical importance for many diseases including diabetes. However, there is no clear evidence so far regarding dose selection for its hepato- and nephroprotective effect in diabetic condition. Hence, the present study aims at evaluating in vitro antioxidant activity, the acute toxicity, and dose fixation of C. cassia bark for their effective medicinal values in streptozotocin (STZ)-induced rats. All the extracts exhibited potential in vitro antioxidant activity and showed a dose-dependent (1000, 2000, 3000, 4000, and 5000 mg/kg BW) acute toxicity by in vivo model. The levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), urea, and creatinine showed a significant elevation in animals treated with the highest dose. In further studies along with histopathological studies, animals treated with STZ (60 mg/kg BW) followed by a different dose (300, 400, and 500 mg/kg BW) of ethanolic extract of the C. cassia bark and glibenclamide (3 mg/kg BW) revealed that the altered level of mitochondrial enzymes, hepatic, and renal marker in STZ-induced animals were restored in C. cassia bark extract-treated group as of control. These results could be of scientific support for the use of the ethanolic extract of the C. cassia bark in folk medicine for the management of diabetes and its associated complications. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Acute toxicity studies and protective effects of Cinnamon cassia bark extract in streptozotocin-induced diabetic rats
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Vijayakumar, K., primary, Rengarajan, R. L., additional, Suganthi, N., additional, Prasanna, B., additional, Velayuthaprabhu, S., additional, Shenbagam, M., additional, and Vijaya Anand, A., additional
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- 2021
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6. Anti-diabetic and hypolipidemic effects of Cinnamon cassia bark extracts: an in vitro, in vivo, and in silico approach
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Vijayakumar, K., primary, Prasanna, B., additional, Rengarajan, R. L., additional, Rathinam, A., additional, Velayuthaprabhu, S., additional, and Vijaya Anand, A., additional
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- 2020
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7. Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion
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Velayuthaprabhu, S. and Archunan, G.
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Women -- Health aspects ,Anticardiolipin antibodies -- Health aspects -- Research ,Antiphospholipid syndrome -- Health aspects -- Research ,Health ,Science and technology ,Research ,Health aspects - Abstract
Byline: S. Velayuthaprabhu, G. Archunan BACKGROUND: Antiphospholipid syndrome (APS) is a major reproductive complication in women, which is characterized by recurrent fetal loss, thrombosis, and thrombocytopenia in association with anticardiolipin [...]
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- 2005
8. Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion
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Archunan, G, primary and Velayuthaprabhu, S, additional
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- 2005
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9. Influence of SERPINA1 Gene Polymorphisms on Anemia and Chronic Obstructive Pulmonary Disease.
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Sangeetha T, Nargis Begum T, Balamuralikrishnan B, Arun M, Rengasamy KRR, Senthilkumar N, Velayuthaprabhu S, Saradhadevi M, Sampathkumar P, and Vijaya Anand A
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- Humans, Polymorphism, Single Nucleotide, Risk Factors, Genetic Predisposition to Disease, Case-Control Studies, alpha 1-Antitrypsin genetics, Pulmonary Disease, Chronic Obstructive genetics, Anemia
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Background: Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear., Aim: The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes. Methodology . The genetic analysis was performed in the SERPINA1 gene of anemia, COPD, and healthy individuals for the analysis of single nucleotide polymorphism at rs28949274 and rs17580 locations. Result and Discussion . The single nucleotide polymorphism at the locations rs28949274 and rs17580 was present in both anemic and COPD patients. The COPD patients were more prone to mutations (63% had rs28949274, and 11% had rs17580 polymorphisms) than the anemic patients (40% had rs28949274, and 1% had rs17580 polymorphisms). On the basis of altitude, high-altitude individuals were found to be more susceptible to both the polymorphisms., Conclusion: Based on the current findings, we suggest that the SERPINA1 gene has a positive correlation with anemia as well as COPD, and the increase in altitude also influences the diseased conditions in a positive manner., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 Thangavelu Sangeetha et al.)
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- 2022
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10. Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats.
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Balasubramanian B, Liu WC, Arumugam VA, Gurupalraj DMM, Ramasamy M, Madhavan S, Velayuthaprabhu S, and Park S
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- Male, Rats, Animals, Carbon Tetrachloride, Antioxidants pharmacology, Antioxidants metabolism, Rats, Wistar, Plant Extracts pharmacology, Plant Extracts metabolism, Oxidative Stress, Liver, Ethanol pharmacology, Lipid Peroxidation, Euphorbia, Chemical and Drug Induced Liver Injury drug therapy, Chemical and Drug Induced Liver Injury etiology, Chemical and Drug Induced Liver Injury prevention & control
- Abstract
Objectives: The present study aims to investigate the protective effect of Euphorbia thymifolia and Euphorbia hirta extracts on in vitro antioxidant activity and in vivo analysis on hepatic marker enzyme levels and histopathological changes in the liver of carbon tetrachloride (CCl
4 ) induced hepatotoxicity rats., Materials and Methods: This study includes 42 adult male Albino Wistar rats randomly divided into seven treatment groups, including control (basal diet, G1), CCl4 -induced single dose (1.5 ml/kg, i.p.) as the negative control (G2), G1 supplemented with 300 mg/kg of ethanol extract of E. thymifolia (G3) and E. hirta (G4), G2 supplemented with 300 mg/kg of ethanol extract of E. thymifolia (G5), E. hirta (G6), and silymarin (25 mg/kg b.w.) used as a standard drug (G7) for 21-days experimental period., Results: The ethanolic extracts of E. thymifolia and E. hirta exhibited potential in vitro antioxidant activity in a dose-dependent manner (25 μg/ml, 50 μg/ml, 100 μg/ml, 200 μg/ml and 250 μg/ml). Oxidative stress caused by CCl4 -induced the liver damage, including changes in liver marker enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase), enzymatic (superoxide dismutase and catalase), non-enzymatic antioxidants (lipid peroxides and glutathione) and hepatocellular alterations such as hydropic degeneration, irregular hepatocytes, and distention of the vein. Administration of E. thymifolia and E. hirta significantly ( p < 0.05) restored the enzyme activity along with the histology of the liver., Conclusion: The results from the current study demonstrate that E. thymifolia and E. hirta have the property of restoring hepatic redox capacity and antioxidant activities against CCl4 -induced acute liver damage.- Published
- 2022
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11. Cardio-protective effects of terminalia catappa leaves and terminalia chebula fruit extract in doxorubicin-induced cardiomyopathy in rats.
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Manikandan R, Balasubramanian B, Punniyakotti P, Vijaya Anand A, Meyyazhagan A, Velayuthaprabhu S, Rengarajan RL, Issara U, and Liu WC
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- Animals, Creatine Kinase, Doxorubicin adverse effects, Fruit, Male, Plant Extracts chemistry, Plant Extracts pharmacology, Propranolol, Rats, Rats, Wistar, Cardiomyopathies chemically induced, Cardiomyopathies drug therapy, Cardiomyopathies prevention & control, Terminalia chemistry
- Abstract
Background: The cardio-protective effects of Terminalia catappa and Terminalia chebula are well-recognized in Ayurveda for its antimicrobial, antidiabetic and antioxidant potentials. The present study evaluates the effects of T. catappa leaves (Tct.LE) and T. chebula fruits (Tce.FE) against doxorubicin (DOX)-induced rats through analysis of the cardiac biomarkers, tricarboxylic acid (TCA) cycle enzymes and respiratory chain enzymes for their cardio-protective properties., Materials and Methods: This study includes 42 adult male Albino Wistar rats randomized into seven groups for 21-days. Groups were categorized as control; DOX (1.5 mg/kg) induced negative control; basal diet with 300 mg/kg of Tct.LE, with 300 mg/kg Tce.FE; DOX with 300 mg/kg of Tct.LE, Tce.FE, and propranolol (25 mg/kg)., Results and Discussion: The doses of 300 mg/kg of both plants have a significant effect on the TCA cycle, respiratory and lysosomal enzymes activity. The troponin levels are significantly reduced in plant treated group than the DOX-treated rats when compared with the control and propranolol treated group. Likewise, the increased level of creatine kinase-muscle/MB, creatine kinase and lipid profile in the DOX-treated animals were significantly reduced upon being treated with extracts., Conclusion: The cardio-protective activity of Tct.LE leaves and Tce.FE indicate its potential use in the management of cardiovascular diseases.
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- 2022
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12. Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2.
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Anand AV, Balamuralikrishnan B, Kaviya M, Bharathi K, Parithathvi A, Arun M, Senthilkumar N, Velayuthaprabhu S, Saradhadevi M, Al-Dhabi NA, Arasu MV, Yatoo MI, Tiwari R, and Dhama K
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- Antiviral Agents chemistry, Humans, India, Phytochemicals chemistry, Plant Extracts pharmacology, SARS-CoV-2 chemistry, COVID-19 Drug Treatment, Antiviral Agents pharmacology, Phytochemicals pharmacology, Plants, Medicinal chemistry, SARS-CoV-2 pathogenicity
- Abstract
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemicals pose a ray of hope for human health during this pandemic, and a great deal of research is concentrated on it. Phytochemicals have been used as antiviral agents against several viruses since they could inhibit several viruses via different mechanisms of direct inhibition either at the viral entry point or the replication stages and via immunomodulation potentials. Recent evidence also suggests that some plants and its components have shown promising antiviral properties against SARS-CoV-2. This review summarizes certain phytochemical agents along with their mode of actions and potential antiviral activities against important viral pathogens. A special focus has been given on medicinal plants and their extracts as well as herbs which have shown promising results to combat SARS-CoV-2 infection and can be useful in treating patients with COVID-19 as alternatives for treatment under phytotherapy approaches during this devastating pandemic situation.
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- 2021
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13. Relationship Between Fetal Loss and Serum Gonadal Hormones Level in Experimental Antiphospholipid Syndrome Mouse.
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Velayuthaprabhu S, Chinnathambi A, Alharbi SA, Matsubayashi H, and Archunan G
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To investigate the effects of antiphospholipid antibodies on establishment of pregnancy and changes in hormones such as estradiol-17ß (E
2 ) and progesterone (P) levels in circulation. Hence, mice were immunized with human β2-Glycoprotein I (β2GPI) and the effect of these antibodies on fetuses weight, placental obsrvation, Serum levels of P and E2 in pregnant mice, hematological were observed. Immunization of mice with human β2 -GPI resulted in elevated levels of antiphospholipid antibodies. The experimentally induced antiphospholipid syndrome mouse showed higher rate of fetal resorption, low number of viable fetuses, and "placental abnormalities". In these animals, serum E2 and P levels were reduced significantly. In addition, the blood cell variation among APS induced and control mice were determined. No significant variations were observed in number of Red Blood Cell count, White Blood Cell count and Hemoglobin content, while platelet number was significantly reduced as compared to control. These results clearly demonstrate that human β2 -GPI might be involved in causing gestational failure in APS by exerting their effect on serum hormones.- Published
- 2017
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14. Expression of apoptosis in placenta of experimental antiphospholipid syndrome mouse.
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Velayuthaprabhu S, Matsubayashi H, Sugi T, Nakamura M, Ohnishi Y, Ogura T, and Archunan G
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- Animals, Antibodies, Anticardiolipin immunology, Antiphospholipid Syndrome pathology, Apoptosis immunology, Female, Fetal Resorption immunology, Humans, Lupus Coagulation Inhibitor administration & dosage, Lupus Coagulation Inhibitor immunology, Male, Mice, Mice, Inbred ICR, Models, Animal, Placenta immunology, Placenta pathology, Pregnancy, Pregnancy Complications pathology, Thrombosis immunology, Antiphospholipid Syndrome immunology, Placenta metabolism, Pregnancy Complications immunology
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Problem: To study the histopathology and expression of apoptosis in placenta of pregnancy-complicated antiphospholipid syndrome (APS)-positive mouse models., Method of Study: ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples., Results: Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen., Conclusion: Our study showed the pathogenic role of aCL and LA in pregnancy complications., (© 2013 John Wiley & Sons A/S.)
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- 2013
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15. A unique preliminary study on placental apoptosis in mice with passive immunization of anti-phosphatidylethanolamine antibodies and anti-factor XII antibodies.
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Velayuthaprabhu S, Matsubayashi H, Sugi T, Nakamura M, Ohnishi Y, Ogura T, Tomiyama T, and Archunan G
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- Abortion, Induced, Animals, Antibodies, Antiphospholipid administration & dosage, Antibodies, Antiphospholipid immunology, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal immunology, Apoptosis physiology, Female, Humans, Immunization, Passive adverse effects, Male, Mice, Mice, Inbred ICR, Phosphatidylethanolamines immunology, Placenta drug effects, Placenta immunology, Placenta Diseases etiology, Placenta Diseases physiopathology, Pregnancy, Pregnancy Complications, Cardiovascular pathology, Thrombosis complications, Antibodies, Antiphospholipid adverse effects, Antibodies, Monoclonal adverse effects, Apoptosis drug effects, Factor XII immunology, Fetal Resorption etiology, Placenta pathology
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Problem: Antiphospholipid antibodies have been investigated both in humans and in animal models. In contrast, there are fewer reports describing anti-phosphatidylethanolamine (aPE) antibodies in humans, and there are no reports of animal studies with aPE till date. Clinically, FXII deficiency or anti-FXII antibodies are sometimes associated with aPE in patients with recurrent pregnancy loss. Therefore, we asked whether aPE and/or anti-FXII in mice could cause fetal resorption, placental thrombosis and apoptosis. Moreover, antibodies to respective target antigens (LDC27 or IPP30) could cause pregnancy failure as well., Methods of Study: Animal models were used to carry out these objectives. All the animals were immunized with different antibodies by passive immunization. Placental samples were used for various observations., Results and Conclusions: Mice with passive immunization of aPE (or anti-LDC27) and aFXII (or anti-IPP30) produced a slight increase in fetal resorption, but markedly induced thrombosis and hemorrhage in the placenta associated with lower platelet counts and increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen. Our study supports the pathogenic role of aPE and aFXII in pregnancy complications and also suggests a beneficial role of LDC27 and IPP30 antigens on pregnancy failures., (© 2011 John Wiley & Sons A/S.)
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- 2011
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16. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats.
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Ramkumar KM, Ponmanickam P, Velayuthaprabhu S, Archunan G, and Rajaguru P
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- Animals, Blood Glucose drug effects, Body Weight drug effects, Diabetes Mellitus, Experimental metabolism, Diabetes Mellitus, Experimental pathology, Diabetic Nephropathies metabolism, Diabetic Nephropathies pathology, Electrophoresis, Polyacrylamide Gel, Glyburide pharmacology, Kidney drug effects, Kidney pathology, Lipid Peroxidation drug effects, Male, Organ Size drug effects, Oxidative Stress drug effects, Plants, Medicinal, Proteinuria drug therapy, Proteinuria metabolism, Rats, Rats, Wistar, Antioxidants pharmacology, Diabetes Mellitus, Experimental drug therapy, Diabetic Nephropathies drug therapy, Gymnema chemistry, Hypoglycemic Agents pharmacology, Plant Extracts pharmacology
- Abstract
Gymnema montanum Hook (Asclepiadaceae), is an endemic plant species of India, traditionally used for diabetes and its management. In this experiment, the ethanol extract of G. montanum (GLEt) at a dose of 200mg/kg body weight was tested to evaluate its effect on renal damage in alloxan-induced diabetic rats and the efficacy was compared with standard hypoglycemic drug, glibenclamide (600 microg/kg body weight). The GLEt and glibenclamide were administered orally for 3 weeks and the effects on glucose, insulin, renal markers including urea, creatinine and uric acid, lipid peroxidation markers including thiobarbituric reactive substances (TBARS) and hydroperoxides and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in kidney were studied. In addition, the urinary protein profile was studied using SDS-PAGE. The results indicated that the GLEt significantly normalized the elevated blood glucose, renal markers and lipid peroxidation markers and increased antioxidant levels in diabetic kidney. The diabetic rats excreted large amount of proteins than untreated rats which was normalized during the treatment with GLEt. In conclusion, the GLEt was found to be more effective in reducing oxidative stress, thus confirming the ethnopharmacological use of G. montanum in protecting diabetes and its complications.
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- 2009
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17. Antihyperlipidaemic effect of Gymnema montanum: a study on lipid profile and fatty acid composition in experimental diabetes.
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Ramkumar KM, Vijayakumar RS, Ponmanickam P, Velayuthaprabhu S, Archunan G, and Rajaguru P
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- Animals, Blood Glucose analysis, Diabetes Mellitus, Experimental blood, Diabetes Mellitus, Experimental enzymology, Hyperlipidemias blood, Hyperlipidemias enzymology, Insulin blood, Kidney enzymology, Liver enzymology, Male, Phytotherapy, Plant Extracts therapeutic use, Plant Leaves, Rats, Rats, Wistar, Diabetes Mellitus, Experimental drug therapy, Fatty Acids metabolism, Gymnema, Hyperlipidemias drug therapy, Hypolipidemic Agents therapeutic use, Lipids blood, Plant Preparations therapeutic use
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In the present study, the antihyperlipidaemic efficacy of ethanol extract of Gymnema montanum leaves was investigated in alloxan-induced diabetic rats and the effect was compared to standard hypoglycaemic drug, glibenclamide. Male adult albino Wistar rats were injected with freshly prepared solution of alloxan monohydrate (150 mg/kg body weight) to induce diabetes. After 2 weeks, the rats with moderate diabetes were administered G. montanum leaves (200 mg/kg body weight) for 21 days by gastric lavage, after which serum, liver and kidney samples were analysed for lipid profile, lipoprotein changes and fatty acid composition. While the alloxan-induced diabetic rats showed a significant increase in the levels of cholesterol, triglycerides and free fatty acids, the levels in the animals treated with G. montanum leaves were considerably reduced and restored to near normal values. Antihyperlipidaemic effects of G. montanum leaves were found to be comparable with that of glibenclamide. Similarly, G. montanum leaves treatment resulted in reversal of alterations observed in the plasma lipoproteins (high-density lipoprotein, low-density lipoprotein and very high-density lipoprotein-cholesterol) and fatty acid composition in serum, liver and kidney of alloxan-induced rats. Our study suggests that phytochemicals present in G. montanum may play an important role in suppressing the elevated lipid profile in diabetes and may be useful for the prevention and/or early treatment of diabetes-associated hyperlipidaemia.
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- 2008
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18. Placental thrombosis in experimental anticardiolipin antibodies-mediated intrauterine fetal death.
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Velayuthaprabhu S, Archunan G, and Balakrishnan K
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- Animals, Antibodies, Anticardiolipin blood, Enzyme-Linked Immunosorbent Assay, Female, Fetus, Mice, Placenta blood supply, Placenta immunology, Pregnancy, Stillbirth, Thrombosis immunology, beta 2-Glycoprotein I immunology, Antibodies, Anticardiolipin immunology, Fetal Death immunology, Placenta pathology, Thrombosis pathology
- Abstract
Problem: Anticardiolipin (aCL) antibodies are associated with stillbirths, recurrent miscarriages and recurrent in vitro fertilization implantation failure in women. Previous animal studies have demonstrated that these antibodies can cause early fetal demise and implantation failure in mice, but most previous studies have not allowed the immunized mice to proceed to the full term of gestation., Method of Study: Mice were immunized with either cardiolipin alone or cardiolipin in combination with beta2-glycoprotein I (beta2GPI) and have studied the effects of these antibodies on pregnancies which were allowed to progress to term., Results: Immunization with cardiolipin alone induced significant levels of anticardiolipin antibodies in mice, but immunization with a combination of cardiolipin and beta2GPI produced even higher levels of antibodies. Mice with elevated levels of anticardiolipin antibodies had poor pregnancy outcomes. This study confirms previous results that anticardiolipin antibodies cause early pregnancy losses and also demonstrates that these antibodies cause stillbirth-like late fetal demise. This study further demonstrated that very high levels of anticardiolipin antibodies cause intrauterine death by facilitating the thrombotic episode in placenta., Conclusions: The present study concludes that the possible mechanism involves in stillbirth of aCL is possibly because of the thrombotic events of placenta.
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- 2007
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