516 results on '"Venerito, Marino"'
Search Results
2. Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer
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Shi, Wenjie, Wartmann, Thomas, Accuffi, Sara, Al-Madhi, Sara, Perrakis, Aristotelis, Kahlert, Christoph, Link, Alexander, Venerito, Marino, Keitel-Anselmino, Verena, Bruns, Christiane, Croner, Roland S., Zhao, Yue, and Kahlert, Ulf D.
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- 2024
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3. ASO Visual Abstract: Adjuvant Gemcitabine Versus Neoadjuvant/Adjuvant FOLFIRINOX in Resectable Pancreatic Cancer—The Randomized Multicenter Phase II NEPAFOX Trial
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Goetze, Thorsten O., Reichart, Alexander, Bankstahl, Ulli S., Pauligk, Claudia, Loose, Maria, Kraus, Thomas W., Elshafei, Moustafa, Bechstein, Wolf O., Trojan, Jörg, Behrend, Matthias, Homann, Nils, Venerito, Marino, Bohle, Wolfram, Varvenne, Michael, Bolling, Claus, Behringer, Dirk M., Kratz-Albers, Karsten, Siegler, Gabriele M., Hozaeel, Wael, and Al-Batran, Salah-Eddin
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- 2024
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4. Atezolizumab/bevacizumab or lenvatinib in hepatocellular carcinoma: Multicenter real-world study with focus on bleeding and thromboembolic events
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Ben Khaled, Najib, Möller, Marie, Jochheim, Leonie S., Leyh, Catherine, Ehmer, Ursula, Böttcher, Katrin, Pinter, Matthias, Balcar, Lorenz, Scheiner, Bernhard, Weich, Alexander, Leicht, Hans Benno, Zarka, Valentina, Ye, Liangtao, Schneider, Julia, Piseddu, Ignazio, Öcal, Osman, Rau, Monika, Sinner, Friedrich, Venerito, Marino, Gairing, Simon Johannes, Förster, Friedrich, Mayerle, Julia, De Toni, Enrico N., Geier, Andreas, and Reiter, Florian P.
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- 2024
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5. Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations
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Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas
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- 2023
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6. Comparison of the management of Helicobacter pylori infection between the older and younger European populations
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Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas
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- 2023
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7. Study protocol of an open-label, single arm phase II trial investigating the efficacy and safety of Trifluridine/Tipiracil combined with irinotecan as a second line therapy in patients with cholangiocarcinoma (TRITICC)
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Kehmann, Linde, Berres, Marie-Luise, Gonzalez-Carmona, Maria, Modest, Dominik P., Mohr, Raphael, Wree, Alexander, Venerito, Marino, Strassburg, Christian, Keitel, Verena, Trautwein, Christian, Luedde, Tom, and Roderburg, Christoph
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- 2023
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8. Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial
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Strasser, Simone, Thompson, Alexander, Roohullah, Aflah, Sievert, William, Andelkovic, Vladimir, Knox, Jennifer, Davies, Janine, Asselah, Jamil, Brahmania, Mayur, Majeed, Habeeb, Villanueva, Luis, Yanez Weber, Patricio, Garrido, Marcelo, Pizarro, Gonzalo Ignacio, Yanez, Nicolas, Xu, Ruocai, Ou, Shuangyan, Ren, Zhenggang, Pan, Hongming, Meng, Zhiqiang, Gu, Kangsheng, Chen, Xi, Zhang, Tao, Hao, Chunyi, Cao, Peiguo, Guo, Yabing, Qin, Shukui, Xiao, Juxiang, Fang, Weijia, Wang, Xin, Bai, Yuxian, Chen, Xiaoming, Yan, Dong, Zhao, Hong, Ying, Jieer, Bonilla, Carlos, Urrego, Olga, Zambrano, Angela, Lema, Mauricio, Restrepo Gutierrez, Juan Carlos, Cardona, Andres, Franco Millan, Sandra, Oscar, Madiedo, Ramos, Victor, Merle, Philippe, LeSourd, Samuel, Edeline, Julien, Bronowicki, Jean-Pierre, Bourliere, Marc, Cattan, Stephane, Bouattour, Mohamed, Mineur, Laurent, Regnault, Helene, Dauvois, Barbara, Schulze, Kornelius, Folprecht, Gunnar, Geier, Andreas, Waidmann, Oliver, Finkelmeier, Fabian, Venerito, Marino, Berres, Marie-Luise, Berg, Thomas, Lange, Christian, Schmidt, Hartmut, Waldschmidt, Dirk T, Bitzer, Michael, McDermott, Ray, Duffy, Austin, Masi, Gianluca, Zagonel, Vittorina, Tonini, Giuseppe, Piscaglia, Fabio, Gori, Stefania, Rizzo, Mimma, Biscaldi, Elisa, Foltran, Luisa, Cabibbo, Giuseppe, Ikeda, Masafumi, Kudo, Masatoshi, Aikata, Hiroshi, Numata, Kazushi, Marusawa, Hiroyuki, Kato, Naoya, Kurosaki, Masayuki, Morimoto, Manabu, Yamashita, Tatsuya, Koga, Hironori, Masaki, Tsutomu, Tateishi, Ryosuke, Inaba, Yoshitaka, Arakawa, Tomohiro, Suzuki, Yoshiyuki, Akua, Norio, Kobayashi, Masahiro, Hosaka, Tetsuya, Nakamuta, Makoto, Oza, Noriko, Kondo, Shunsuke, Furuse, Junji, Nagashima, Fumio, Kitano, Masayuki, Takaguchi, Koichi, Ryoo, Baek-Yeol, Lim, Ho Yeong, Kim, Jee Hyun, Kim, Tae-You, Kim, Han Sang, Hernandez Hernandez, Carlos, Motola Kuba, Daniel, Segura Gonzalez, Manuel, Cabrera Luviano, Jesus, Huitzil Melendez, Fidel, Ramirez Godinez, Francisco, Silva-Bravo, Fernando, Gane, Edward, Stedman, Catherine, Kwiatkowski, Mariusz, Wyrwicz, Lucjan, Nowakowska-Zajdel, Ewa, Kraj, Leszek, Janczewska, Ewa, Surma-Wlodarczyk, Renata, Breder, Valeriy, Sekacheva, Marina, Orlova, Rashida, Vasilyev, Alexander, Zukov, Ruslan, Vladimirov, Vladimir, Minguez, Beatriz, Matilla Pena, Ana, Fernandez Castroagudin, Javier, Romero Gomez, Manuel, Luis Lledo, Jose, Rubin, Angel, Garcia Sanchez, Araceli, Calleja Panero, Jose, Yu, Ming-Chin, Shen, Ying-Chun, Huang, Yi-Hsiang, Jeng, Long-Bin, Chang, Ting-Tsung, Yang, Sheng-Shun, Chen, Shinn-Cherng, Dechaphunkul, Arunee, Tanwandee, Tawesak, Leerapun, Apinya, Seker, Mesut, Harputluoglu, Hakan, Cicin, Irfan, Oksuzoglu, Berna, Bilici, Mehmet, Sezgin Goksu, Sema, Artac, Mehmet, Cil, Timucin, Yalcin, Suayib, Meyer, Tim, Sarker, Debashis, Rao, Ankit, Palmer, Daniel, Evans, Jeff, Hubner, Richard, Finn, Richard, Ulahannan, Susanna, Zakari, Ahmed, Feun, Lynn, Al-Rajabi, Raed, Sung, Max, He, Aiwu, Kardosh, Adel, Goyal, Lipika, Li, Daneng, Choi, Minsig, Posada, Juan, Dodlapati, Jyothi, Shroff, Rachna, Agrawal, Saurabh, Gopaluni, Srivalli, Akce, Mehmet, Alese, Olatunji, Baron, Ari, Dunne, Richard, Loaiza-Bonilla, Arturo, Frenette, Catherine, Llovet, Josep M, Kumada, Hiromitsu, Cheng, Ann-Lii, Galle, Peter R, Kaneko, Shuichi, Wang, Anran, Mody, Kalgi, Dutcus, Corina, Dubrovsky, Leonid, Siegel, Abby B, and Finn, Richard S
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- 2023
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9. Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial
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Akce, Mehmet, Ales Diaz, Inmaculada, Alves, Gustavo, Anand, Sumitra, Arslan, Cagatay, Asselah, Jamil, Assenat, Eric, Aubin, Francine, Bai, Li-Yuan, Bai, Yuxian, Barajas, Olga, Bates, Susan, Begbie, Stephen, Ben-Aharon, Irit, Beri, Nina, Berres, Marie-Luise, Blanc, Jean-Frederic, Borbath, Ivan, Bordonaro, Robert, Bouattour, Mohamed, Brandi, Giovanni, Burgoyne, Adam, Butthongkomvong, Kritiya, Camandaroba, Marcos, Cao, Ke, Carballido, Marcela, Chan, Stephan Lam, Chen, Jen-Shi, Chen, Ming-Huang, Chen, Xiaoming, Cheng, Ashley, Chiu, Tai-Jan, Choi, Hye Jin, Chon, Hong Jae, Collignon, Joelle, Cubillo Gracian, Antonio, Davis, Sarah, de Carvalho, Ricardo Saraiva, de Groot, D.J.A., Demols, Anne, De Vos, Judith, Diab, Maria, Easaw, Jacob, Eatock, Martin, Edeline, Julien, Elias, Rawad, Eskens, Fredericus, Falcone, Alfredo, Fernandez, Plinio, Finn, Richard, Franke, Fabio, Furukawa, Masayuki, Furuse, Junji, Gbolahan, Olumide, Geboes, Karen, Geneser, Keri-Lee, Geng, Zhimin, Geva, Ravit, Gillmore, Roopinder, Goetze, Thorsten, Gou, Hongfeng, Grasselli, Julieta, Gu, Shanzhi, Gumus, Mahmut, Haj Mohammad, Nadia, Hao, Chunyi, Harputluoglu, Hakan, Hatoum, Hassan, Heinemann, Volker, Ho, Wang Kwong, Hsu, Chiun, Hubert, Ayala, Hwang, Juneul, Inanc, Mevlude, Iseas, Soledad, Jeyasingam, Vaishnavi, Jimenez Fonseca, Paula, Joubert, Warren, Juengsamarn, Jitlada, Kaen, Diego, Kanai, Masashi, Kasper-Virchow, Stefan, Kazemi, Ghazaleh, Kelleher, Fergal, Kelley, Robin, Kim, Jin Won, Kim, Jong Gwang, Kinupe Abrahao, Ana Beatriz, Klumpen, Heinz, Kochenderfer, Mark, Kose, Fatih, Lam, Ho Ching, Lee, Choong-kun, Lee, Hyun Woo, Lee, Margaret, Lee, Myung Ah, Lee, Wai Man Sarah, Le Sourd, Samuel, Li, Dongliang, Li, Wei, Liang, Houjie, Liang, Tingbo, Lim, Chun Sen, Lingerfelt, Brian, Lopez, Charles, Low, John, Macarulla Mercade, Teresa, Malka, David, Mao, Yimin, Masi, Gianluca, McCune, Steven, McDermott, Ray, McWhirter, Elaine, Mendez, Guillermo, Milella, Michele, Mizuno, Nobumasa, Mizutani, Tomonori, Moniz, Camila, Morales, Luisa, Munoz Martin, Andres Jesús, Nervi, Bruno, Ngamphaiboon, Nuttapong, Oh, Sang Cheul, Oksuzoglu, Berna, Outlaw, Darryl, Ozaka, Masato, Ozguroglu, Mustafa, Ozyilkan, Ozgur, Painemal, Claudio, Pan, Yueyin, Park, Joon Oh, Pelzer, Uwe, Peng, Chuang, Petorin, Caroline, Pezet, Denis, Power, Derek, Qin, Shukui, Ren, Zhenggang, Roohullah, Aflah, Ryu, Hyewon, Salman, Pamela, Sasaki, Mitsuhito, Sasidharan, Rita, Satoh, Taroh, Schulze, Kornelius, Scott-Brown, Martin, Segovia, Ruben, Seufferlein, Thomas, Siena, Salvatore, Sinapi, Isabelle, Smolenschi, Cristina, Song, Tianqiang, Sookprasert, Aumkhae, Soparattanapaisarn, Nopadol, Starling, Naureen, Stein, Stacey, Stemmer, Salomon, Su, Haichuan, Sugimoto, Rie, Suksombooncharoen, Thatthan, Tam, Vincent, Tan, Ai Lian, Tan, Chih Kiang, Tanasanvimon, Suebpong, Tonini, Giuseppe, Tortora, Giampaolo, Tsuji, Akihito, Ueno, Makoto, Uribe, Rodrigo, Venerito, Marino, Verdaguer Mata, Helena, Verslype, Chris, Victorino, Ana Paula, Vogel, Arndt, Wade, James, Waldschmidt, Dirk Thomas, Wang, Lu, Wan Isahk, Wan Zamaniah, Wasan, Harpeet, Weschenfelder, Rui, Wong, Chun Yin, Wong, Yoke Fui, Yalcin, Suayib, Yanez Weber, Patricio, Yang, Xuezhong, Yasui, Hisateru, Yau, Thomas, Yazici, Ozan, Yen, Chia-Jui, Ying, Jieer, Yoo, Changhoon, Yu, Wenchang, Zhao, Haitao, Kelley, Robin Kate, Finn, Richard S, Klümpen, Heinz-Josef, Chan, Stephen L, Valle, Juan W, Yu, Li, Malhotra, Usha, and Siegel, Abby B
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- 2023
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10. Efficacy and safety of immune checkpoint inhibitor rechallenge in individuals with hepatocellular carcinoma
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Scheiner, Bernhard, Roessler, Daniel, Phen, Samuel, Lim, Mir, Pomej, Katharina, Pressiani, Tiziana, Cammarota, Antonella, Fründt, Thorben W., von Felden, Johann, Schulze, Kornelius, Himmelsbach, Vera, Finkelmeier, Fabian, Deibel, Ansgar, Siebenhüner, Alexander R., Shmanko, Kateryna, Radu, Pompilia, Schwacha-Eipper, Birgit, Ebert, Matthias P., Teufel, Andreas, Djanani, Angela, Hucke, Florian, Balcar, Lorenz, Philipp, Alexander B., Hsiehchen, David, Venerito, Marino, Sinner, Friedrich, Trauner, Michael, D'Alessio, Antonio, Fulgenzi, Claudia A.M., Pinato, David J., Peck-Radosavljevic, Markus, Dufour, Jean-François, Weinmann, Arndt, Kremer, Andreas E., Singal, Amit G., De Toni, Enrico N., Rimassa, Lorenza, and Pinter, Matthias
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- 2023
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11. THU-457 Outcome of liver transplantation in patients with hepatocellular carcinoma previously treated with immune checkpoint inhibitorbased therapy-first results from an international multicenter registry
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Bauer, Ulrike, primary, Ben Khaled, Najib, additional, Grottenthaler, Julia M., additional, Foerster, Friedrich, additional, Blümel, Sena, additional, Heinrich, Sophia, additional, Sinner, Friedrich, additional, Venerito, Marino, additional, Taubert, Richard, additional, Kremer, Andreas E., additional, Weinmann, Arndt, additional, Berg, Christoph P., additional, Lange, Christian M., additional, de Toni, Enrico, additional, Schmid, Roland M., additional, and Ehmer, Ursula, additional
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- 2024
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12. OS-112-YI Outcome and management of patients with hepatocellular carcinoma who achieved complete response to immunotherapybased systemic therapy
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Scheiner, Bernhard, primary, Kang, Beodeul, additional, Balcar, Lorenz, additional, Radu, Pompilia, additional, Reiter, Florian P, additional, Adžić, Gordan, additional, Guo, Jiang, additional, Gao, Xu, additional, Yuan, Xiao, additional, Cheng, Long, additional, Gorgulho, Joao, additional, Schultheiß, Michael, additional, Khaled, Najib Ben, additional, Sinner, Friedrich, additional, D'Alessio, Antonio, additional, Pomej, Katharina, additional, Saborowski, Anna, additional, Schwacha-Eipper, Birgit, additional, Zarka, Valentina, additional, Lampichler, Katharina, additional, Nishida, Naoshi, additional, Lee, Pei-Chang, additional, Krall, Anja, additional, Saeed, Anwaar, additional, Himmelsbach, Vera, additional, Tesini, Giulia, additional, Wietharn, Brooke, additional, Huang, Yi-Hsiang, additional, Vivaldi, Caterina, additional, Masi, Gianluca, additional, Vogel, Arndt, additional, Schulze, Kornelius, additional, Trauner, Michael, additional, Stauber, Rudolf E., additional, Kudo, Masatoshi, additional, Dekervel, Jeroen, additional, Parikh, Neehar, additional, Dufour, Jean-François, additional, Prejac, Juraj, additional, Geier, Andreas, additional, Bengsch, Bertram, additional, von Felden, Johann, additional, Venerito, Marino, additional, Philipp, Alexander, additional, Finkelmeier, Fabian, additional, Ji, Fanpu, additional, Wang, Hung-Wei, additional, Rimassa, Lorenza, additional, Pinato, David J., additional, Bouattour, Mohamed, additional, Chon, Hong Jae, additional, and Pinter, Matthias, additional
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- 2024
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13. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)
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Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.
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- 2022
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14. Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer
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Repetto, Ombretta, De Re, Valli, Giuffrida, Paolo, Lenti, Marco Vincenzo, Magris, Raffaella, Venerito, Marino, Steffan, Agostino, Di Sabatino, Antonio, and Cannizzaro, Renato
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- 2021
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15. Comparative Efficacy of Cabozantinib and Ramucirumab After Sorafenib for Patients with Hepatocellular Carcinoma and Alpha-fetoprotein ≥ 400 ng/mL: A Matching-Adjusted Indirect Comparison
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Trojan, Jörg, Mollon, Patrick, Daniele, Bruno, Marteau, Florence, Martín, Lidia, Li, Yuxin, Xu, Qing, Piscaglia, Fabio, Zaucha, Renata, Sarker, Debashis, Lim, Ho Yeong, and Venerito, Marino
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- 2021
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16. Systemic Treatment of Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Multicenter Trial.
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Himmelsbach, Vera, Jeschke, Matthias, Lange, Christian M., Scheiner, Bernhard, Pinter, Matthias, Sinner, Friedrich, Venerito, Marino, Queck, Alexander, Trojan, Jörg, Waidmann, Oliver, and Finkelmeier, Fabian
- Subjects
PREVENTION of surgical complications ,CANCER relapse ,STATISTICAL significance ,PROTEIN-tyrosine kinase inhibitors ,LOGISTIC regression analysis ,RETROSPECTIVE studies ,SORAFENIB ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,LOG-rank test ,DRUG efficacy ,RESEARCH ,MEDICAL records ,ACQUISITION of data ,SURVIVAL analysis (Biometry) ,CONFIDENCE intervals ,PROGRESSION-free survival ,DATA analysis software ,HEPATOCELLULAR carcinoma ,LIVER transplantation ,IMMUNOSUPPRESSION ,OVERALL survival ,PROPORTIONAL hazards models - Abstract
Simple Summary: Liver transplant is an approach for the curative treatment of early stage hepatocellular carcinoma and the often underlying liver cirrhosis. However, a recurrence of the cancer is to be expected in 10 to 20% of cases after liver transplantation. The treatment of recurrent hepatocellular carcinoma remains difficult, as immunotherapy is usually not recommended for systemic treatment after transplantation. Therefore, it is often necessary to resort to tyrosine kinase inhibitors in advanced stage hepatocellular carcinoma. This multicenter trial aims at assessing the effect of tyrosine kinase inhibitors and immunosuppression on the outcome of patients with recurrent hepatocellular carcinoma after liver transplantation. Introduction: The tyrosine kinase inhibitors (TKIs) sorafenib and lenvatinib represent the first-line systemic therapy of choice for patients with hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). Under sorafenib and lenvatinib, HCC patients have shown increasingly improved overall survival in clinical studies over the years. In contrast, data on overall survival for patients with HCC recurrence after LT under TKIs are scarce and limited to small retrospective series. In this retrospective, multicenter study, we investigated the efficacy of TKI therapy and the influence of immunosuppression in patients with HCC recurrence after LT. Methods: Retrospective data were collected from four transplant centers from Germany and Austria. We included patients with HCC recurrence after LT between 2007 and 2020 who were treated with a TKI. Results: In total, we analyzed data from 46 patients with HCC recurrence after LT. The most common underlying liver disease was hepatitis C, accounting for 52.2%. The median time to relapse was 11.8 months (range 0–117.7 months). The liver graft was affected in 21 patients (45.7%), and 36 patients (78.3%) had extrahepatic metastases at initial diagnosis of recurrence, with the lung being the most commonly affected (n = 25, 54.3%). Of the total, 54.3% (n = 25) of the patients were initially treated locally; 39 (85.8%) and 7 (15.2%) patients received sorafenib and lenvatinib, respectively, as first-line systemic therapy. Median overall survival of the whole cohort was 10.9 months (95% confidence interval (95% CI) 6.9–14.9 months) and median progression free survival was 5.7 months (95% CI 2.0–9.4 months) from treatment initiation. Conclusion: Since history of liver transplantation is considered a contraindication for immunotherapy, prognosis of patients with HCC recurrence after LT remains poor. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Radiation-induced damage in the upper gastrointestinal tract: clinical presentation, diagnostic tests and treatment options
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Afifi, Ahmed N.A.M., Powerski, Maciej, Jechorek, Dörthe, Brunner, Thomas B., Weigt, Jochen, and Venerito, Marino
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- 2020
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18. Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance
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Bujanda, Luis, primary, Nyssen, Olga P., additional, Ramos, June, additional, Bordin, Dmitry S., additional, Tepes, Bojan, additional, Perez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Castro-Fernandez, Manuel, additional, Lerang, Frode, additional, Leja, Mārcis, additional, Rodrigo, Luis, additional, Rokkas, Theodore, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Shvets, Oleg, additional, Gasbarrini, Antonio, additional, Simsek, Halis, additional, Phull, Perminder S., additional, Buzás, György Miklós, additional, Machado, Jose C., additional, Boltin, Doron, additional, Boyanova, Lyudmila, additional, Tonkić, Ante, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Vologzanina, Ludmila, additional, Fadieienko, Galina D., additional, Fiorini, Giulia, additional, Resina, Elena, additional, Muñoz, Raquel, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Megraud, Francis, additional, Morain, Colm O., additional, Montes, Milagrosa, additional, and Gisbert, Javier P., additional
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- 2024
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19. Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial
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Llovet, Josep M, primary, Kudo, Masatoshi, additional, Merle, Philippe, additional, Meyer, Tim, additional, Qin, Shukui, additional, Ikeda, Masafumi, additional, Xu, Ruocai, additional, Edeline, Julien, additional, Ryoo, Baek-Yeol, additional, Ren, Zhenggang, additional, Masi, Gianluca, additional, Kwiatkowski, Mariusz, additional, Lim, Ho Yeong, additional, Kim, Jee Hyun, additional, Breder, Valeriy, additional, Kumada, Hiromitsu, additional, Cheng, Ann-Lii, additional, Galle, Peter R, additional, Kaneko, Shuichi, additional, Wang, Anran, additional, Mody, Kalgi, additional, Dutcus, Corina, additional, Dubrovsky, Leonid, additional, Siegel, Abby B, additional, Finn, Richard S, additional, Strasser, Simone, additional, Thompson, Alexander, additional, Roohullah, Aflah, additional, Sievert, William, additional, Andelkovic, Vladimir, additional, Knox, Jennifer, additional, Davies, Janine, additional, Asselah, Jamil, additional, Brahmania, Mayur, additional, Majeed, Habeeb, additional, Villanueva, Luis, additional, Yanez Weber, Patricio, additional, Garrido, Marcelo, additional, Pizarro, Gonzalo Ignacio, additional, Yanez, Nicolas, additional, Ou, Shuangyan, additional, Pan, Hongming, additional, Meng, Zhiqiang, additional, Gu, Kangsheng, additional, Chen, Xi, additional, Zhang, Tao, additional, Hao, Chunyi, additional, Cao, Peiguo, additional, Guo, Yabing, additional, Xiao, Juxiang, additional, Fang, Weijia, additional, Wang, Xin, additional, Bai, Yuxian, additional, Chen, Xiaoming, additional, Yan, Dong, additional, Zhao, Hong, additional, Ying, Jieer, additional, Bonilla, Carlos, additional, Urrego, Olga, additional, Zambrano, Angela, additional, Lema, Mauricio, additional, Restrepo Gutierrez, Juan Carlos, additional, Cardona, Andres, additional, Franco Millan, Sandra, additional, Oscar, Madiedo, additional, Ramos, Victor, additional, LeSourd, Samuel, additional, Bronowicki, Jean-Pierre, additional, Bourliere, Marc, additional, Cattan, Stephane, additional, Bouattour, Mohamed, additional, Mineur, Laurent, additional, Regnault, Helene, additional, Dauvois, Barbara, additional, Schulze, Kornelius, additional, Folprecht, Gunnar, additional, Geier, Andreas, additional, Waidmann, Oliver, additional, Finkelmeier, Fabian, additional, Venerito, Marino, additional, Berres, Marie-Luise, additional, Berg, Thomas, additional, Lange, Christian, additional, Schmidt, Hartmut, additional, Waldschmidt, Dirk T, additional, Bitzer, Michael, additional, McDermott, Ray, additional, Duffy, Austin, additional, Zagonel, Vittorina, additional, Tonini, Giuseppe, additional, Piscaglia, Fabio, additional, Gori, Stefania, additional, Rizzo, Mimma, additional, Biscaldi, Elisa, additional, Foltran, Luisa, additional, Cabibbo, Giuseppe, additional, Aikata, Hiroshi, additional, Numata, Kazushi, additional, Marusawa, Hiroyuki, additional, Kato, Naoya, additional, Kurosaki, Masayuki, additional, Morimoto, Manabu, additional, Yamashita, Tatsuya, additional, Koga, Hironori, additional, Masaki, Tsutomu, additional, Tateishi, Ryosuke, additional, Inaba, Yoshitaka, additional, Arakawa, Tomohiro, additional, Suzuki, Yoshiyuki, additional, Akua, Norio, additional, Kobayashi, Masahiro, additional, Hosaka, Tetsuya, additional, Nakamuta, Makoto, additional, Oza, Noriko, additional, Kondo, Shunsuke, additional, Furuse, Junji, additional, Nagashima, Fumio, additional, Kitano, Masayuki, additional, Takaguchi, Koichi, additional, Kim, Tae-You, additional, Kim, Han Sang, additional, Hernandez Hernandez, Carlos, additional, Motola Kuba, Daniel, additional, Segura Gonzalez, Manuel, additional, Cabrera Luviano, Jesus, additional, Huitzil Melendez, Fidel, additional, Ramirez Godinez, Francisco, additional, Silva-Bravo, Fernando, additional, Gane, Edward, additional, Stedman, Catherine, additional, Wyrwicz, Lucjan, additional, Nowakowska-Zajdel, Ewa, additional, Kraj, Leszek, additional, Janczewska, Ewa, additional, Surma-Wlodarczyk, Renata, additional, Sekacheva, Marina, additional, Orlova, Rashida, additional, Vasilyev, Alexander, additional, Zukov, Ruslan, additional, Vladimirov, Vladimir, additional, Minguez, Beatriz, additional, Matilla Pena, Ana, additional, Fernandez Castroagudin, Javier, additional, Romero Gomez, Manuel, additional, Luis Lledo, Jose, additional, Rubin, Angel, additional, Garcia Sanchez, Araceli, additional, Calleja Panero, Jose, additional, Yu, Ming-Chin, additional, Shen, Ying-Chun, additional, Huang, Yi-Hsiang, additional, Jeng, Long-Bin, additional, Chang, Ting-Tsung, additional, Yang, Sheng-Shun, additional, Chen, Shinn-Cherng, additional, Dechaphunkul, Arunee, additional, Tanwandee, Tawesak, additional, Leerapun, Apinya, additional, Seker, Mesut, additional, Harputluoglu, Hakan, additional, Cicin, Irfan, additional, Oksuzoglu, Berna, additional, Bilici, Mehmet, additional, Sezgin Goksu, Sema, additional, Artac, Mehmet, additional, Cil, Timucin, additional, Yalcin, Suayib, additional, Sarker, Debashis, additional, Rao, Ankit, additional, Palmer, Daniel, additional, Evans, Jeff, additional, Hubner, Richard, additional, Finn, Richard, additional, Ulahannan, Susanna, additional, Zakari, Ahmed, additional, Feun, Lynn, additional, Al-Rajabi, Raed, additional, Sung, Max, additional, He, Aiwu, additional, Kardosh, Adel, additional, Goyal, Lipika, additional, Li, Daneng, additional, Choi, Minsig, additional, Posada, Juan, additional, Dodlapati, Jyothi, additional, Shroff, Rachna, additional, Agrawal, Saurabh, additional, Gopaluni, Srivalli, additional, Akce, Mehmet, additional, Alese, Olatunji, additional, Baron, Ari, additional, Dunne, Richard, additional, Loaiza-Bonilla, Arturo, additional, and Frenette, Catherine, additional
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- 2023
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20. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study
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Dong, Jing, Gharahkhani, Puya, Chow, Wong-Ho, Gammon, Marilie D., Liu, Geoffrey, Caldas, Carlos, Wu, Anna H., Ye, Weimin, Onstad, Lynn, Anderson, Lesley A., Bernstein, Leslie, Pharoah, Paul D., Risch, Harvey A., Corley, Douglas A., Fitzgerald, Rebecca C., Iyer, Prasad G., Reid, Brian J., Lagergren, Jesper, Shaheen, Nicholas J., Vaughan, Thomas L., MacGregor, Stuart, Love, Sharon, Palles, Claire, Tomlinson, Ian, Gockel, Ines, May, Andrea, Gerges, Christian, Anders, Mario, Böhmer, Anne C., Becker, Jessica, Kreuser, Nicole, Thieme, Rene, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Schmidt, Claudia, Izbicki, Jakob R., Hölscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Mayershofer, Rupert, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M., Moebus, Susanne, Knapp, Michael, Peters, Wilbert H.M., Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Jankowski, Janusz, Schumacher, Johannes, Neale, Rachel E., Whiteman, David C., and Thrift, Aaron P.
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- 2019
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21. Long-term treatment with streptozocin/5-fluorouracil chemotherapy in patients with metastatic pancreatic neuroendocrine tumors: Case series
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Müller, Christian, Kreissl, Michael C., Klose, Silke, Krause, Andreas, Keitel, Verena, and Venerito, Marino
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- 2022
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22. Role of compliance in Helicobacter pylorieradication treatment: Results of the European Registry on H. pylorimanagement
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Huguet, Jose M., Ferrer‐Barceló, Luis, Suárez, Patrícia, Barcelo‐Cerda, Susana, Sempere, Javier, Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez‐Aísa, Ángeles, Jonaitis, Laimas, Tepes, Bojan, Castro‐Fernandez, M., Pabón‐Carrasco, Manuel, Keco‐Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez‐Domínguez, Samuel J., Alfaro Almajano, Enrique, Rodrigo, Luis, Vologzanina, Ludmila, Bordin, Dmitry S., Gasbarrini, Antonio, Babayeva, Gülüstan, Lerang, Frode, Leja, Mārcis, Kupčinskas, Juozas, Rokkas, Theodore, Marcos‐Pinto, Ricardo, Meštrović, Antonio, Gridnyev, Oleksiy, Phull, Perminder S., Smith, Sinead M., Boltin, Doron, Buzás, György Miklós, Kral, Jan, Şimşek, Halis, Matysiak‐Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano‐Català, Anna, Moreira, Leticia, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.
- Abstract
Adherence to Helicobacter pylori (H. pylori)eradication treatment is a cornerstone for achieving adequate treatment efficacy. To determine which factors influence compliance with treatment. A systematic prospective non‐interventional registry (Hp‐EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG‐REDCap e‐CRF and were subjected to quality control. Modified intention‐to‐treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance. Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non‐compliance rate was higher in patients prescribed longer regimens (10‐, 14‐days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non‐adherence was lower for first‐line treatment than for rescue treatment (1.5% vs. 2.2%; p< 0.001). Differences in non‐adherence in the three most frequent first‐line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non‐compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p< 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2–7.7]; p< 0.001). Compliance with Helicobacter pylorieradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue‐treatment, prolonged treatment regimens, the presence of adverse events, and the use of non‐bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.
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- 2024
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23. The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases.
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Koebbe, Laura L., Hess, Timo, Giel, Ann-Sophie, Bigge, Jessica, Gehlen, Jan, Schueller, Vitalia, Geppert, Michael, Dumoulin, Franz Ludwig, Heller, Joerg, Schepke, Michael, Plaßmann, Dominik, Vieth, Michael, Venerito, Marino, Schumacher, Johannes, and Maj, Carlo
- Subjects
GENETIC regulation ,GENE expression ,LOCUS (Genetics) ,BODY composition ,TRANSCRIPTOMES ,PLANT protection - Abstract
Tissue-specific gene expression and gene regulation lead to a better understanding of tissue-specific physiology and pathophysiology. We analyzed the transcriptome and genetic regulatory profiles of two distinct gastric sites, corpus and antrum, to identify tissue-specific gene expression and its regulation. Gastric corpus and antrum mucosa biopsies were collected during routine gastroscopies from up to 431 healthy individuals. We obtained genotype and transcriptome data and performed transcriptome profiling and expression quantitative trait locus (eQTL) studies. We further used data from genome-wide association studies (GWAS) of various diseases and traits to partition their heritability and to perform transcriptome-wide association studies (TWAS). The transcriptome data from corpus and antral mucosa highlights the heterogeneity of gene expression in the stomach. We identified enriched pathways revealing distinct and common physiological processes in gastric corpus and antrum. Furthermore, we found an enrichment of the single nucleotide polymorphism (SNP)-based heritability of metabolic, obesity-related, and cardiovascular traits and diseases by considering corpus- and antrum-specifically expressed genes. Particularly, we could prioritize gastric-specific candidate genes for multiple metabolic traits, like NQO1 which is involved in glucose metabolism, MUC1 which contributes to purine and protein metabolism or RAB27B being a regulator of weight and body composition. Our findings show that gastric corpus and antrum vary in their transcriptome and genetic regulatory profiles indicating physiological differences which are mostly related to digestion and epithelial protection. Moreover, our findings demonstrate that the genetic regulation of the gastric transcriptome is linked to biological mechanisms associated with metabolic, obesity-related, and cardiovascular traits and diseases. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer
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Shi, Wenjie, primary, Wartmann, Thomas, additional, Accuffi, Sara, additional, Al-Madhi, Sara, additional, Perrakis, Aristotelis, additional, Kahlert, Christoph, additional, Link, Alexander, additional, Venerito, Marino, additional, Keitel-Anselmino, Verena, additional, Bruns, Christiane, additional, Croner, Roland S., additional, Zhao, Yue, additional, and Kahlert, Ulf D., additional
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- 2023
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25. Bei Diagnose oft schon fortgeschritten, Therapie stadienadaptiert
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Bose, Katrin, Canbay, Ali, and Venerito, Marino
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- 2019
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26. S-1 in Patients with Advanced Esophagogastric Adenocarcinoma: Results from the Safety Compliance Observatory on Oral fluoroPyrimidines (SCOOP) Study
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Venerito, Marino
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- 2019
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27. Helicobacter pylori Infection: New Facts in Clinical Management
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Malfertheiner, Peter, Venerito, Marino, and Schulz, Christian
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- 2018
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28. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”
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Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional
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- 2023
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29. Dissecting the genetic heterogeneity of gastric cancer
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Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Gehlen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional
- Published
- 2023
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30. Risk of bleeding and thromboembolic events with atezolizumab/bevacizumab or lenvatinib in patients with hepatocellular carcinoma: a multicenter, retrospective study
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Khaled, Najib Ben, primary, Möller, Marie, additional, Jochheim, Leonie, additional, Leyh, Catherine, additional, Ehmer, Ursula, additional, Böttcher, Katrin, additional, Leicht, Hans Benno, additional, Rau, Monika, additional, Sinner, Friedrich, additional, Venerito, Marino, additional, Gairing, Simon Johannes, additional, Foerster, Friedrich, additional, de Toni, Enrico, additional, Geier, Andreas, additional, and Reiter, Florian P, additional
- Published
- 2023
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31. Helicobacter pylori and Gastric Cancer: Timing and Impact of Preventive Measures
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Venerito, Marino, Vasapolli, Riccardo, Malfertheiner, Peter, Jansen, Marnix, editor, and Wright, Nicholas A., editor
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- 2016
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32. Multidisciplinary Treatment of Patients with Progressive Biliary Tract Cancer after First-Line Gemcitabine and Cisplatin: A Single-Center Experience
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Müller, Christian, primary, Omari, Jazan, additional, Mohnike, Konrad, additional, Bär, Caroline, additional, Pech, Maciej, additional, Keitel, Verena, additional, and Venerito, Marino, additional
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- 2023
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33. Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial
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Tempero, Margaret A., primary, Pelzer, Uwe, additional, O'Reilly, Eileen M., additional, Winter, Jordan, additional, Oh, Do-Youn, additional, Li, Chung-Pin, additional, Tortora, Giampaolo, additional, Chang, Heung-Moon, additional, Lopez, Charles D., additional, Bekaii-Saab, Tanios, additional, Ko, Andrew H., additional, Santoro, Armando, additional, Park, Joon Oh, additional, Noel, Marcus S., additional, Frassineti, Giovanni Luca, additional, Shan, Yan-Shen, additional, Dean, Andrew, additional, Riess, Hanno, additional, Van Cutsem, Eric, additional, Berlin, Jordan, additional, Philip, Philip, additional, Moore, Malcolm, additional, Goldstein, David, additional, Tabernero, Josep, additional, Li, Mingyu, additional, Ferrara, Stefano, additional, Le Bruchec, Yvan, additional, Zhang, George, additional, Lu, Brian, additional, Biankin, Andrew V., additional, Reni, Michele, additional, Epstein, Richard, additional, Vasey, Paul, additional, Shapiro, Jeremy, additional, Burge, Matthew, additional, Chua, Yu Jo, additional, Harris, Marion, additional, Pavlakis, Nick, additional, Tebbutt, Niall, additional, Prager, Gerald, additional, Dittrich, Christian, additional, Längle, Friedrich, additional, Philipp-Abbrederis, Kathrin, additional, Greil, Richard, additional, Stöger, Herbert, additional, Girschikofsky, Michael, additional, Kuehr, Thomas, additional, Van Laethem, Jean-Luc, additional, Laurent, Stéphanie, additional, Dhani, Neesha, additional, Ko, Yoo Joung, additional, Dowden, Scot, additional, Kavan, Petr, additional, Tehfe, Mustapha Édouard, additional, Kubala, Eugen, additional, Kohoutek, Milan, additional, Pfeiffer, Per, additional, Yilmaz, Mette, additional, Parner, Vibeke, additional, Salminen, Tapio, additional, Soveri, Leena-Maija, additional, Korkeila, Eija, additional, Osterlund, Pia, additional, Taieb, Julien, additional, Tougeron, David, additional, Artru, Pascal, additional, Caroli-Bosc, François Xavier, additional, Guimbaud, Rosine, additional, Turpin, Antony, additional, Walter, Thomas, additional, Bachet, Jean Baptiste, additional, Kunzmann, Volker, additional, Kreth, Florian, additional, Block, Andreas, additional, Venerito, Marino, additional, Oettle, Helmut, additional, Karthaus, Meinolf, additional, Trojan, Jörg, additional, Folprecht, Gunnar, additional, Lerch, Markus, additional, Kullmann, Frank, additional, Reiser, Marcel, additional, Heinemann, Volker, additional, Wörns, Marcus-Alexander, additional, Schulz, Holger, additional, Garlipp, Benjamin, additional, Yau, Thomas, additional, Chan, Lam Stephen, additional, Juhasz, Balazs, additional, Landherr, László, additional, Pinter, Tamas, additional, Bodoky, György, additional, Kahán, Zsuzsanna, additional, McDermott, Raymond, additional, Power, Derek, additional, Gianni, Luca, additional, Siena, Salvatore, additional, Milella, Michele, additional, Falcone, Alfredo, additional, Berardi, Rossana, additional, Bagalà, Cinzia, additional, Di Costanzo, Francesco, additional, Roila, Fausto, additional, Ardizzoni, Andrea, additional, Maiello, Evaristo, additional, Fanello, Silvia, additional, Wilmink, Johanna, additional, Willem de Groot, Jan, additional, Creemers, Geert, additional, Barroso, Eduardo, additional, Rodrigues, Tânia, additional, Sarmento, Cristina, additional, Chee, Cheng Ean, additional, Tai, David, additional, Mercade, Teresa Macarulla, additional, Medina, Manuel Hidalgo, additional, Mena, Alfredo Carrato, additional, Santasusana, Joan Maurel, additional, Flor Oncala, Maria Jose, additional, Martin, Carlos Gomez, additional, Lopez, Rafael, additional, Muñoz, Andres, additional, Garcia, Ruth Vera, additional, Ales, Inmaculada, additional, Sáez, Berta Laquente, additional, Rivera, Fernando, additional, Sastre, Javier, additional, Wu, Cheng-Chung, additional, Tien, Yu-Wen, additional, Chan, De-Chuan, additional, Hwang, Tsann-Long, additional, Evans, Jeffry, additional, Wadsley, Jonathan, additional, Corrie, Pippa, additional, Biankin, Andrew, additional, Ko, Andrew, additional, Cardin, Dana, additional, Chiorean, Elena, additional, Bendell, Johanna, additional, Noonan, Anne, additional, Kindler, Hedy, additional, Fernando, Nishan, additional, Beg, Muhammad, additional, George, Thomas, additional, Noel, Marcus, additional, LoConte, Noelle, additional, Arena, Francis, additional, Posey, James, additional, Malhotra, Rajat, additional, Lopez, Charles, additional, Sohal, Davendra, additional, McWilliams, Robert, additional, Brenner, Warren, additional, Womack, Mark, additional, Seth, Rahul, additional, lyer, Renuka, additional, Bahary, Nathan, additional, Marsh, Robert, additional, Ramirez, Robert, additional, Chua, Cynthia, additional, Reeves, James, additional, Manji, Gulam, additional, El-Khoueiry, Anthony, additional, Weaver, Robert, additional, Sahai, Vaibhav, additional, Messersmith, Wells, additional, Dreicer, Robert, additional, Zakari, Ahmed, additional, Bullock, Andrea, additional, Musher, Benjamin, additional, Borad, Mitesh, additional, Kim, Edward, additional, Bajor, David, additional, Huyck, Tim, additional, Hatoum, Hassan, additional, Xiong, Henry, additional, Pasche, Boris, additional, Lacy, Jill, additional, Olowokure, Olugbenga, additional, Cohn, Allen, additional, Richards, Donald, additional, Martin, Robert, additional, Paulson, Andrew, additional, Fanta, Paul, additional, Krishnamurthi, Smitha, additional, Oberstein, Paul, additional, and Fuloria, Jyotsna, additional
- Published
- 2023
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34. Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial
- Author
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Kelley, Robin Kate, primary, Ueno, Makoto, additional, Yoo, Changhoon, additional, Finn, Richard S, additional, Furuse, Junji, additional, Ren, Zhenggang, additional, Yau, Thomas, additional, Klümpen, Heinz-Josef, additional, Chan, Stephen L, additional, Ozaka, Masato, additional, Verslype, Chris, additional, Bouattour, Mohamed, additional, Park, Joon Oh, additional, Barajas, Olga, additional, Pelzer, Uwe, additional, Valle, Juan W, additional, Yu, Li, additional, Malhotra, Usha, additional, Siegel, Abby B, additional, Edeline, Julien, additional, Vogel, Arndt, additional, Akce, Mehmet, additional, Ales Diaz, Immaculada, additional, Alves, Gustavo, additional, Anand, Sumitra, additional, Arslan, Cagatay, additional, Asselah, Jamil, additional, Assenat, Eric, additional, Aubin, Francine, additional, Bai, Li-Yuan, additional, Bai, Yuxian, additional, Bates, Susan, additional, Begbie, Stephen, additional, Ben-Aharon, Irit, additional, Beri, Nina, additional, Berres, Marie-Luise, additional, Blanc, Jean-Frederic, additional, Borbath, Ivan, additional, Bordonaro, Robert, additional, Brandi, Giovanni, additional, Burgoyne, Adam, additional, Butthongkomvong, Kritiya, additional, Cao, Ke, additional, Carballido, Marcela, additional, Camandaroba, Marcos, additional, Chang, Stephan Lam, additional, Chen, Jen-Shi, additional, Chen, Ming-Huang, additional, Chen, Xiaoming, additional, Cheng, Ashley, additional, Chiu, Tai-Jan, additional, Choi, Hye Jin, additional, Chon, Hong Jae, additional, Collignon, Joelle, additional, Cubillo Gracian, Antonio, additional, Davis, Sarah, additional, de Carvalho, Ricardo Saraiva, additional, de Groot, D.J.A., additional, Demols, Anne, additional, De Vos, Judith, additional, Diab, Maria, additional, Easaw, Jacob, additional, Eatock, Martin, additional, Elias, Rawad, additional, Eskens, Fredericus, additional, Falcone, Alfredo, additional, Fernandez, Plinio, additional, Finn, Richard, additional, Franke, Fabio, additional, Furukawa, Masayuki, additional, Gbolahan, Olumide, additional, Geboes, Karen, additional, Geneser, Keri-Lee, additional, Geng, Zhimin, additional, Geva, Ravit, additional, Gillmore, Roopinder, additional, Goetze, Thorsten, additional, Gou, Hongfeng, additional, Grasselli, Julieta, additional, Gu, Shanzhi, additional, Gumus, Mahmut, additional, Haj Mohammad, Nadia, additional, Hao, Chunyi, additional, Harputluoglu, Hakan, additional, Hatoum, Hassan, additional, Heinemann, Volker, additional, Ho, Wang Kwong, additional, Hsu, Chiun, additional, Hubert, Ayala, additional, Hwang, Juneul, additional, Inanc, Mevlude, additional, Iseas, Soledad, additional, Jeyasingam, Vaishnavi, additional, Jimenez Fonseca, Paula, additional, Joubert, Warren, additional, Juengsamarn, Jitlada, additional, Kaen, Diego, additional, Kanai, Masahi, additional, Kasper-Virchow, Stefan, additional, Kazemi, Ghazaleh, additional, Kelleher, Fergal, additional, Kelley, Robin, additional, Kim, Jin Won, additional, Kim, Jong Gwang, additional, Kinupe Abrahao, Ana Beatriz, additional, Klumpen, Heinz, additional, Kochenderfer, Mark, additional, Kose, Fatih, additional, Lam, Ho Ching, additional, Lee, Choong-kun, additional, Lee, Hyun Woo, additional, Lee, Margaret, additional, Lee, Myung Ah, additional, Lee, Wai Man Sarah, additional, Le Sourd, Samuel, additional, Li, Dongliang, additional, Li, Wei, additional, Liang, Houjie, additional, Liang, Tingbo, additional, Lim, Chun Sen, additional, Lingerfelt, Brian, additional, Lopez, Charles, additional, Low, John, additional, Macarulla Mercade, Teresa, additional, Malka, David, additional, Mao, Yimin, additional, Masi, Gianluca, additional, McCune, Steven, additional, McDermott, Ray, additional, McWhirter, Elaine, additional, Mendez, Guillermo, additional, Milella, Michele, additional, Mizutani, Tomonori, additional, Moniz, Camila, additional, Morales, Luisa, additional, Munoz Martin, Andres Jesús, additional, Nervi, Bruno, additional, Ngamphaiboon, Nuttapong, additional, Oh, Sang Cheul, additional, Oksuzoglu, Berna, additional, Outlaw, Darryl, additional, Ozguroglu, Mustafa, additional, Ozyilkan, Ozgur, additional, Painemeal, Claudio, additional, Pan, Yueyin, additional, Peng, Chuang, additional, Petorin, Caroline, additional, Pezet, Denis, additional, Power, Derek, additional, Qin, Shukui, additional, Roohullah, Aflah, additional, Ryu, Hyewon, additional, Salman, Pamela, additional, Sasidharan, Rita, additional, Satho, Taroh, additional, Schulze, Kornelius, additional, Scott-Brown, Martin, additional, Segovia, Ruben, additional, Seufferlin, Thomas, additional, Siena, Salvatore, additional, Sinapi, Isabelle, additional, Smolenschi, Cristina, additional, Song, Tianqiang, additional, Sookprasert, Aumkhae, additional, Soparattanapaisarn, Nopadol, additional, Starling, Naureen, additional, Stein, Stacey, additional, Stemmer, Salomon, additional, Su, Haichuan, additional, Sugimoto, Rie, additional, Suksombooncharoen, Thatthan, additional, Tam, Vincent, additional, Tan, Ai Lian, additional, Tan, Chih Kiang, additional, Tanasanvimon, Suebpong, additional, Tonini, Giuseppe, additional, Tortora, Giampaolo, additional, Tsuji, Akihito, additional, Uribe, Rodrigo, additional, Venerito, Marino, additional, Verdaguer Mata, Helena, additional, Victorino, Ana Paula, additional, Wade, James, additional, Waldschmidt, Dirk Thomas, additional, Wang, Lu, additional, Wan Isahk, Wan Zamaniah, additional, Wasan, Harpeet, additional, Weschenfelder, Rui, additional, Wong, Chun Yin, additional, Wong, Yoke Fui, additional, Yalcin, Suayib, additional, Yanez Weber, Patricio, additional, Yang, Xuezhong, additional, Yasui, Hisateru, additional, Yazici, Ozan, additional, Yen, Chia-Jui, additional, Ying, Jieer, additional, Yu, Wenchang, additional, and Zhao, Haitao, additional
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- 2023
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35. 129 - EFECTIVIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI EN FUNCIÓN DE LAS RESISTENCIAS ANTIBIÓTICAS: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Bujanda, Luis, primary, Nyssen, Olga P., additional, Ramos, June, additional, Bordin, Dmitry S., additional, Tepes, Bojan, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Castro-Fernández, Manuel, additional, Lerang, Frode, additional, Leja, Marcis, additional, Rodrigo, Luis, additional, Rokkas, Theodore, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Shvets, Oleg, additional, Gasbarrini, Antonio, additional, Simsek, Halis, additional, Phull, Perminder S, additional, Buzás, Gyorgiy Miklós, additional, Machado, Jose C., additional, Boltin, Doron, additional, Boyanova, Lyudmila, additional, Tonkic, Ante, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Vologzanina, Ludmila, additional, Fadieienko, Galina D, additional, Fiorini, Giulia, additional, Resina, Elena, additional, Muñoz, Raquel, additional, Cano-Catalá, Anna, additional, Puig, Ignasi, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Megraud, Francis, additional, Morain, Colm O, additional, and Gisbert, Javier P., additional
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- 2023
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36. Dissecting the genetic heterogeneity of gastric cancer
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Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, Schumacher, Johannes, Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes
- Abstract
Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular me, Errata: Hess, T., Maj, C., Gehlen, J. et. al. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”. eBioMedicine. 2023:94:104709. DOI: 10.1016/j.ebiom.2023.104709
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- 2023
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37. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis
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Gharahkhani, Puya, Fitzgerald, Rebecca C, Vaughan, Thomas L, Palles, Claire, Gockel, Ines, Tomlinson, Ian, Buas, Matthew F, May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Böhmer, Anne C, Izbicki, Jakob R, Hölscher, Arnulf H, Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M, Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, de Caestecker, John, Harrison, Rebecca, Love, Sharon B, MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, R G Peter, Iyer, Prasad G, Anderson, Lesley A, Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J, Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A, Wu, Anna H, Ye, Weimin, Bird, Nigel C, Shaheen, Nicholas J, Gammon, Marilie D, Corley, Douglas A, Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H M, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C, Jankowski, Janusz, and Schumacher, Johannes
- Published
- 2016
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38. Lowest Case Fatality Rate for Patients With Acute Pancreatitis Admitted in Gastroenterology Units in Veneto Region, Italy
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Cavallaro, Lucas Giovanni, Germanà, Bastianello, Venerito, Marino, Frulloni, Luca, Farinati, Fabio, Gabbrielli, Armando, and Saia, Mario
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- 2019
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39. Atezolizumab plus bevacizumab beyond first-line in hepatocellular carcinoma
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Sinner, Friedrich, additional, Pinter, Matthias, additional, Scheiner, Bernhard, additional, Ettrich, Thomas, additional, Sturm, Niklas, additional, Gonzalez-Carmona, MariaA., additional, Waidmann, Oliver, additional, Finkelmeier, Fabian, additional, Himmelsbach, Vera, additional, de Toni, EnricoN., additional, Ben-Khaled, Najib, additional, Mohr, Raphael, additional, Fründt, ThorbenWilhelm, additional, Kütting, Fabian, additional, van Bömmel, Florian, additional, Lieb, Sabine, additional, Krug, Sebastian, additional, Bettinger, Dominik, additional, Schultheiß, Michael, additional, Jochheim, Leonie, additional, Best, Jan, additional, Keitel, Verena, additional, Müller, Christian, additional, and Venerito, Marino, additional
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- 2023
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40. PAPEL DEL USO DE PROBIÓTICOS EN LA EFECTIVIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Carrasco, Manuel Pabón, additional, Huerga, Alma Keco-, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D, additional, Huguet, José M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional
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- 2023
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41. 135 - TENDENCIAS DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVE A LO LARGO DE 10 AÑOS (2013-2022) EN EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Nyssen, Olga P., primary, Jonaitis, Laimas, additional, Pérez-Aísa, Ángeles, additional, Vaira, Dino, additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Bordin, Dmitry, additional, Huerga, Alma Keco-, additional, Castro-Fernández, Manuel, additional, Lucendo, Alfredo, additional, Vologzhanina, Liudmila, additional, Bujanda, Luis, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Lanas, Angel, additional, Martínez-Dominguez, Samuel, additional, Alfaro, Enrique, additional, Leja, Marcis, additional, Bumane, Renate, additional, Mammadov, Emin, additional, Babayeva, Gulustan, additional, Mahmudov, Umud, additional, Caldas, María, additional, Rodrigo, Luis, additional, Lerang, Frode, additional, Fadieienko, Galyna, additional, Abdulkhakov, Rustam, additional, Malavés, Jose María Huguet, additional, Zaytsev, Oleg, additional, Ilchishina, Tatiana, additional, Fernández-Salazar, Luis, additional, Alcaide, Noelia, additional, Velayos, Benito, additional, Sarsenbaeva, Aiman Silkanovna, additional, Bakulin, Igor, additional, Gravina, Antonietta G., additional, Romano, Marco, additional, Perona, Mónica, additional, Alekseenko, Sergey, additional, Barrio, Jesús, additional, Areia, Miguel, additional, Nuñez, Óscar, additional, Bogomolov, Pavel, additional, Rodríguez, Blas José Gómez, additional, Cajal, Manuel Dominguez-, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jiménez, additional, Georgopoulos, Sotirios, additional, Notari, Pedro Almela, additional, Tonkic, Ante, additional, Pellicano, Rinaldo, additional, Simsek, Halis, additional, Kunovský, Lumír, additional, Gasbarrini, Antonio, additional, Bote, Jose Maria Botargues, additional, Buzas, Gyorgy M, additional, Fernández-Bermejo, Miguel, additional, Phull, Perminder, additional, Venerito, Marino, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Link, Alexander, additional, Iyo, Eduardo, additional, Kupinskas, Juozas, additional, Shvets, Oleg, additional, Pinto, Ricardo Marcos, additional, Rokkas, Theodore, additional, Simsek, Ilkay, additional, Smith, Sinead, additional, Boltin, Doron, additional, Lamarque, Dominique, additional, Dobru, Daniela, additional, Marlicz, Wojciech, additional, Milivojevic, Vladimir, additional, Boyanova, Lyudmila, additional, Lamy, Vincent, additional, Doulberis, Michael, additional, Bytzer, Peter, additional, Capelle, Lisette, additional, Gridnyev, Oleksiy, additional, Ristimaki, Ari, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional
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- 2023
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42. Multidisciplinary approach for biliary tract cancer after progression to first-line therapy with gemcitabine and cisplatin: post-progression survival and safety outcomes
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Müller, Christian, additional, Keitel, Verena, additional, and Venerito, Marino, additional
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- 2023
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43. 130 - COMPARACIÓN DE LA EFECTIVIDAD DE LOS TRATAMIENTOS ERRADICADORES MÁS FRECUENTES ENTRE LAS POBLACIONES MÁS MAYORES Y MÁS JÓVENES DE EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Jonaitis, Paulius, primary, Nyssen, Olga P., additional, Saracino, Ilaria Maria, additional, Fiorini, Giulia, additional, Vaira, Dino, additional, Pérez-Aísa, Ángeles, additional, Tepes, Bojan, additional, Castro-Fernández, M., additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Lucendo, Alfredo J, additional, Lanas, Ángel, additional, Martínez-Domínguez, Samuel J, additional, Almajano, Enrique Alfaro, additional, Rodrigo, Luis, additional, Vologzanina, Ludmila, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luis, additional, Mahmudov, Umud, additional, Leja, Mrcis, additional, Lerang, Frode, additional, Babayeva, Gülüstan, additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Gridnyev, Oleksiy, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Phull, Perminder S., additional, Smith, Sinead M., additional, Tonki, Ante, additional, Boltin, Doron, additional, Buzás, György Miklós, additional, Kunovský, Lumír, additional, imek, Halis, additional, Matysiak-Budnik, Tamara, additional, Milivojevic, Vladimir, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Doulberis, Michael, additional, Capelle, Lisette G., additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, Gisbert, Javier P., additional, and Jonaitis, Laimas, additional
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- 2023
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44. 127 - IMPACTO DEL USO DE PROBIÓTICOS EN LA SEGURIDAD DE LOS TRATAMIENTOS FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D., additional, Huguet, Jose M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional
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- 2023
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45. 133 - PATRÓN DE PRESCRIPCIÓN DE PROBIÓTICOS ADYUVANTES A LA TERAPIA ERRADICADORA FRENTE A HELICOBACTER PYLORI: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)
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Casas, Diego, primary, Alcedo, Javier, additional, Lafuente, Miguel, additional, López, F. Javier, additional, Pérez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Jonaitis, Laimas, additional, Castro-Fernández, Manuel, additional, Pabón-Carrasco, Manuel, additional, Keco-Huerga, Alma, additional, Voynovan, Irina, additional, Bujanda, Luis, additional, Lucendo, Alfredo J., additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Phull, Perminder S., additional, Rodrigo, Luis, additional, Lanas, Angel, additional, Martínez-Domínguez, Samuel J., additional, Alfaro, Enrique, additional, Fadieienko, Galina D, additional, Huguet, José M., additional, Bordin, Dmitry S., additional, Gasbarrini, Antonio, additional, Kupcinskas, Juozas, additional, Babayeva, Gülüstan, additional, Gridnyev, Oleksiy, additional, Leja, Mrcis, additional, Rokkas, Theodore, additional, Marcos-Pinto, Ricardo, additional, Lerang, Frode, additional, Boltin, Doron, additional, Papp, Veronika, additional, Tonki, Ante, additional, Smith, Sinead M., additional, Simsek, Halis, additional, Venerito, Marino, additional, Boyanova, Lyudmila, additional, Milivojevic, Vladimir, additional, Kunovsky, Lumir, additional, Matysiak-Budnik, Tamara, additional, Marlicz, Wojciech, additional, Doulberis, Michael, additional, Cano-Català, Anna, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Nyssen, Olga P., additional, Megraud, Francis, additional, Morain, Colm O., additional, and Gisbert, Javier P., additional
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- 2023
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46. Empirical rescue treatment ofHelicobacter pyloriinfection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry onH. pylorimanagement (Hp-EuReg)
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Burgos-Santamaría, Diego, primary, Nyssen, Olga P, additional, Gasbarrini, Antonio, additional, Vaira, Dino, additional, Pérez-Aisa, Ángeles, additional, Rodrigo, Luís, additional, Pellicano, Rinaldo, additional, Keco-Huerga, Alma, additional, Pabón-Carrasco, Manuel, additional, Castro-Fernandez, Manuel, additional, Boltin, Doron, additional, Barrio, Jesus, additional, Phull, Perminder, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Ortiz-Polo, Inmaculada, additional, Tepes, Bojan, additional, Lucendo, Alfredo J, additional, Huguet, José María, additional, Areia, Miguel, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Bujanda, Luís, additional, Ramos-San Román, June, additional, Cuadrado-Lavín, Antonio, additional, Gomez-Camarero, Judith, additional, Jiménez Moreno, Manuel Alfonso, additional, Lanas, Angel, additional, Martinez-Dominguez, Samuel Jesús, additional, Alfaro, Enrique, additional, Marcos-Pinto, Ricardo, additional, Milivojevic, Vladimir, additional, Rokkas, Theodore, additional, Leja, Marcis, additional, Smith, Sinead, additional, Tonkić, Ante, additional, Buzás, György Miklós, additional, Doulberis, Michael, additional, Venerito, Marino, additional, Lerang, Frode, additional, Bordin, Dmitry S, additional, Lamy, Vincent, additional, Capelle, Lisette G, additional, Marlicz, Wojciech, additional, Dobru, Daniela, additional, Gridnyev, Oleksiy, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O'Morain, Colm, additional, and Gisbert, Javier P, additional
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- 2022
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47. Atezolizumab Plus Bevacizumab in Patients with Advanced and Progressing Hepatocellular Carcinoma: Retrospective Multicenter Experience
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Sinner, Friedrich, primary, Pinter, Matthias, additional, Scheiner, Bernhard, additional, Ettrich, Thomas Jens, additional, Sturm, Niklas, additional, Gonzalez-Carmona, Maria A., additional, Waidmann, Oliver, additional, Finkelmeier, Fabian, additional, Himmelsbach, Vera, additional, De Toni, Enrico N., additional, Ben Khaled, Najib, additional, Mohr, Raphael, additional, Fründt, Thorben Wilhelm, additional, Kütting, Fabian, additional, Bömmel, Florian van, additional, Lieb, Sabine, additional, Krug, Sebastian, additional, Bettinger, Dominik, additional, Schultheiß, Michael, additional, Jochheim, Leonie S., additional, Best, Jan, additional, Müller, Christian, additional, Keitel, Verena, additional, and Venerito, Marino, additional
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- 2022
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48. GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level
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Schröder, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Böhmer, Anne C., Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M., Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Müller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J., Hölscher, Arnulf H., Lang, Hauke, Grimminger, Peter P., Dakkak, Dani, Vashist, Yogesh, May, Sandra, Görg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismüller, Josef, Dommermuth, Jens, Benner, Udo, Rösch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thaddäus T., Nöthen, Markus M., Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F., Thrift, Aaron P., Vaughan, Thomas L., Tomlinson, Ian, Whiteman, David C., Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes, Prenen, Hans, Wellcome Trust Case Control Consortium 2 (WTCCC2), Esophageal Adenocarcinoma Genetics Consortium (EAGLE), Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), Wellcome Trust Case Control Consortium 2 (WTCCC2), Esophageal Adenocarcinoma Genetics Consortium (EAGLE), and Barrett's and Esophageal Adenocarcinoma Consortium (BEACON)
- Subjects
Gastroenterology ,Human medicine ,Biology - Abstract
ObjectiveOesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett’s oesophagus (BE) as a precursor lesion, is the most prevalent EC subtype in the Western world. This study aims to contribute to better understand the genetic causes of BE/EA by leveraging genome wide association studies (GWAS), genetic correlation analyses and polygenic risk modelling.DesignWe combined data from previous GWAS with new cohorts, increasing the sample size to 16 790 BE/EA cases and 32 476 controls. We also carried out a transcriptome wide association study (TWAS) using expression data from disease-relevant tissues to identify BE/EA candidate genes. To investigate the relationship with reported BE/EA risk factors, a linkage disequilibrium score regression (LDSR) analysis was performed. BE/EA risk models were developed combining clinical/lifestyle risk factors with polygenic risk scores (PRS) derived from the GWAS meta-analysis.ResultsThe GWAS meta-analysis identified 27 BE and/or EA risk loci, 11 of which were novel. The TWAS identified promising BE/EA candidate genes at seven GWAS loci and at five additional risk loci. The LDSR analysis led to the identification of novel genetic correlations and pointed to differences in BE and EA aetiology. Gastro-oesophageal reflux disease appeared to contribute stronger to the metaplastic BE transformation than to EA development. Finally, combining PRS with BE/EA risk factors improved the performance of the risk models.ConclusionOur findings provide further insights into BE/EA aetiology and its relationship to risk factors. The results lay the foundation for future follow-up studies to identify underlying disease mechanisms and improving risk prediction.
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- 2023
49. Functional (Nonulcer) Dyspepsia
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Venerito, Marino, Kandulski, Arne, Malfertheiner, Peter, and Duvnjak, Marko, editor
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- 2011
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50. Therapeutic Approach in Functional (Nonulcer) Dyspepsia
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Kandulski, Arne, Venerito, Marino, Malfertheiner, Peter, and Duvnjak, Marko, editor
- Published
- 2011
- Full Text
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