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11 results on '"Veninga, Vivien"'

1. γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

Author

de Vries, Natasja L., van de Haar, Joris, Veninga, Vivien, Chalabi, Myriam, Ijsselsteijn, Marieke E., van der Ploeg, Manon, van den Bulk, Jitske, Ruano, Dina, van den Berg, Jose G., Haanen, John B., Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Battaglia, Thomas W., Gelderblom, Hans, Verheul, Henk M. W., Schumacher, Ton N., Wessels, Lodewyk F. A., Koning, Frits, de Miranda, Noel F. C. C., and Voest, Emile E.

Published
2023
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3. Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

Author

Chalabi, Myriam, Fanchi, Lorenzo F., Dijkstra, Krijn K., Van den Berg, José G., Aalbers, Arend G., Sikorska, Karolina, Lopez-Yurda, Marta, Grootscholten, Cecile, Beets, Geerard L., Snaebjornsson, Petur, Maas, Monique, Mertz, Marjolijn, Veninga, Vivien, Bounova, Gergana, Broeks, Annegien, Beets-Tan, Regina G., de Wijkerslooth, Thomas R., van Lent, Anja U., Marsman, Hendrik A., Nuijten, Elvira, Kok, Niels F., Kuiper, Maria, Verbeek, Wieke H., Kok, Marleen, Van Leerdam, Monique E., Schumacher, Ton N., Voest, Emile E., and Haanen, John B.

Published
2020
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5. Base editing screens define the genetic landscape of cancer drug resistance mechanisms

Author

Coelho, Matthew A., Strauss, Magdalena E., Watterson, Alex, Cooper, Sarah, Bhosle, Shriram, Illuzzi, Giuditta, Karakoc, Emre, Dinçer, Cansu, Vieira, Sara F., Sharma, Mamta, Moullet, Marie, Conticelli, Daniela, Koeppel, Jonas, McCarten, Katrina, Cattaneo, Chiara M., Veninga, Vivien, Picco, Gabriele, Parts, Leopold, Forment, Josep V., Voest, Emile E., Marioni, John C., Bassett, Andrew, and Garnett, Mathew J.

Abstract

Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate causal variants. Here we prospectively identify genetic mechanisms of resistance to ten oncology drugs from CRISPR base editing mutagenesis screens in four cancer cell lines using a guide RNA library predicted to install 32,476 variants in 11 cancer genes. We identify four functional classes of protein variants modulating drug sensitivity and use single-cell transcriptomics to reveal how these variants operate through distinct mechanisms, including eliciting a drug-addicted cell state. We identify variants that can be targeted with alternative inhibitors to overcome resistance and functionally validate an epidermal growth factor receptor (EGFR) variant that sensitizes lung cancer cells to EGFR inhibitors. Our variant-to-function map has implications for patient stratification, therapy combinations and drug scheduling in cancer treatment.

Published
2024
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6. Base editing screens map mutations affecting interferon-γ signaling in cancer

Author

Coelho, Matthew A., primary, Cooper, Sarah, additional, Strauss, Magdalena E., additional, Karakoc, Emre, additional, Bhosle, Shriram, additional, Gonçalves, Emanuel, additional, Picco, Gabriele, additional, Burgold, Thomas, additional, Cattaneo, Chiara M., additional, Veninga, Vivien, additional, Consonni, Sarah, additional, Dinçer, Cansu, additional, Vieira, Sara F., additional, Gibson, Freddy, additional, Barthorpe, Syd, additional, Hardy, Claire, additional, Rein, Joel, additional, Thomas, Mark, additional, Marioni, John, additional, Voest, Emile E., additional, Bassett, Andrew, additional, and Garnett, Mathew J., additional

Published
2023
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7. Base editing screens map mutations affecting IFNγ signalling in cancer

Author

Coelho, Matthew A., primary, Karakoc, Emre, additional, Bhosle, Shriram, additional, Gonçalves, Emanuel, additional, Burgold, Thomas, additional, Cooper, Sarah, additional, Cattaneo, Chiara M., additional, Veninga, Vivien, additional, Consonni, Sarah, additional, Dinçer, Cansu, additional, Vieira, Sara F., additional, Gibson, Freddy, additional, Barthorpe, Syd, additional, Hardy, Claire, additional, Rein, Joel, additional, Thomas, Mark, additional, Voest, Emile, additional, Bassett, Andrew, additional, and Garnett, Mathew J., additional

Published
2022
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8. γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects

Author

de Vries, Natasja L., primary, van de Haar, Joris, additional, Veninga, Vivien, additional, Chalabi, Myriam, additional, Ijsselsteijn, Marieke E., additional, van der Ploeg, Manon, additional, van den Bulk, Jitske, additional, Ruano, Dina, additional, Haanen, John B., additional, Schumacher, Ton N., additional, Wessels, Lodewyk F.A., additional, Koning, Frits, additional, de Miranda, Noel F.C.C., additional, and Voest, Emile E., additional

Published
2021
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