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826 results on '"Venkataraman, G."'

2. Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial

Author

Zareba, W., Pyykkonen, K., Buttaccio, A., Perkins, E., DeGrey, D., Robertson, S., Moss, A.J., Brown, M., Lansing, R., Oberer, A., Polonsky, B., Ross, V., Papernov, A., Schleede, S., Beck, C., Oakes, D., Feng, C., McNitt S, S., Hall, W.J., Moss, A., Daubert, J., Huang, D., Winters, S., Schuger, C., Haigney, M., Piccini, J., Alexis, J., Chen, L., Miller, A., Richeson, J.F., Rosero, S., Kutyifa, V., Shah, A., Lamas, G., Cohn, F., Harrell, F., Jr., Piña, I., Poole, J., Sullivan, M., Lathrop, D., Geller, N., Boineau, R., Trondell, J., Cooper, L., Itturiaga, E., Gottlieb, C., Greer, S., Perzanowski, C., McPherson, C., Hedgepeth, C., Assal, C., Salam, T., Woollett, I., Tomassoni, G., Ayala-Paredes, F., Russo, A., Punnam, S., Sangrigoli, R., Sloan, S., Kutalek, S., Sun, A., Lustgarten, D., Monir, G., Haithcock, D., Sorrentino, R., Cannom, D., Kluger, J., Varanasi, S., Rashtian, M., Philippon, F., Berger, R., Mazzella, M., Lessmeier, T., Silver, J., Worley, S., Bernabei, M., Esberg, D., Dixon, M., LeLorier, P., Greenberg, Y., Essebag, V., Venkataraman, G., Shinn, T., Dubuc, M., Turitto, G., Henrikson, C., Mirro, M., Raitt, M., Baranchuk, A., O'Neill, G., Lockwood, E., Vloka, M., Hurwitz, J., Mead, R.H., Somasundarum, P., Aziz, E., Rashba, E., Budzikowski, A., Cox, M., Natale, A., Chung, E., Ziv, O., McGrew, F., III, Tamirisa, K., Greenspon, A., Estes, M., Taylor, S., Janardhanan, R., Mitchell, L.B., Burke, M., Attari, M., Mikaelian, B., Hsu, S., Conti, J., Mazur, A., Shorofsky, S., Rosenthal, L., Sakaguchi, S., Wolfe, D., Flaker, G., Saba, S., Aktas, M., Mason, P., Shalaby, A., Musat, D., Abraham, R., Ellenbogen, K., Fellows, C., Kavesh, N., Thomas, G., Hemsworth, D., Williamson, B., Zareba, Wojciech, Daubert, James P., Beck, Christopher A., Huang, David T., Alexis, Jeffrey D., Brown, Mary W., Pyykkonen, Kathryn, McNitt, Scott, Oakes, David, Feng, Changyong, Aktas, Mehmet K., Ayala-Parades, Felix, Baranchuk, Adrian, Dubuc, Marc, Haigney, Mark, Mazur, Alexander, McPherson, Craig A., Mitchell, L. Brent, Natale, Andrea, Piccini, Jonathan P., Raitt, Merritt, Rashtian, Mayer Y., Schuger, Claudio, Winters, Stephen, Worley, Seth J., Ziv, Ohad, and Moss, Arthur J.

Published
2018
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4. Cell surface glypicans are low-affinity endostatin receptors.

Author

Karumanchi, SA, Jha, V, Ramchandran, R, Karihaloo, A, Tsiokas, L, Chan, B, Dhanabal, M, Hanai, JI, Venkataraman, G, Shriver, Z, Keiser, N, Kalluri, R, Zeng, H, Mukhopadhyay, D, Chen, RL, Lander, AD, Hagihara, K, Yamaguchi, Y, Sasisekharan, R, Cantley, L, and Sukhatme, VP

Subjects
Kidney Tubules, Endothelium, CHO Cells, 3T3 Cells, Animals, Mice, Rats, Sulfates, Collagen, Heparin, Oligosaccharides, Endostatins, Peptide Fragments, Membrane Proteins, Collagen Type XVIII, Cloning, Molecular, Gene Expression, Protein Binding, Cricetinae, Heparan Sulfate Proteoglycans, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Endostatin, a collagen XVIII fragment, is a potent anti-angiogenic protein. We sought to identify its endothelial cell surface receptor(s). Alkaline phosphatase- tagged endostatin bound endothelial cells revealing two binding affinities. Expression cloning identified glypican, a cell surface proteoglycan as the lower-affinity receptor. Biochemical and genetic studies indicated that glypicans' heparan sulfate glycosaminoglycans were critical for endostatin binding. Furthermore, endostatin selected a specific octasulfated hexasaccharide from a sequence in heparin. We have also demonstrated a role for endostatin in renal tubular cell branching morphogenesis and show that glypicans serve as low-affinity receptors for endostatin in these cells, as in endothelial cells. Finally, antisense experiments suggest the critical importance of glypicans in mediating endostatin activities.

Published
2001

38. OBITUARY

Author

Venkataraman, G.

Published
1989

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