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8. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

10. Eritema nodoso: Uno, nessuno, centomila

Author

Wiel, Luisa Cortellazzo, Ventura, Giovanna, Berti, Irene, Bramuzzo, Matteo, DA DALT, Eva, Londero, Margherita, Ventura, Alessandro, Wiel, Luisa Cortellazzo, Ventura, Giovanna, Berti, Irene, Bramuzzo, Matteo, DA DALT, Eva, Londero, Margherita, and Ventura, Alessandro

Subjects
Erythema nodosum, IBD, Streptococcus, Subcutaneous nodules, Tubercolosis, Pediatrics, Perinatology and Child Health, Tubercolosi, Subcutaneous nodule, Perinatology and Child Health, Streptococcu, Pediatrics
Abstract

Erythema nodosum is a relatively common form of panniculitis in children. The diagnosis is clinical, based upon the presence of painful erithematous nodules or plaques. Tuberculosis should be always suspected (“one”) but other infective or immunological conditions are now more frequently diagnosed (“one hundred thousand”). In most cases the cause of erythema nodosum will remain unidentified (“no one”). Therapy is that of the underlying disease, while NSAIDs and steroids can be used as symptomatic drugs for more severe cases. Erythema nodosum usually resolves in 2-6 weeks without sequelae, but relapses are possible. This short review discusses the diagnostic and therapeutic approach to erythema nodosum starting with the description of four recent cases.

Published
2017

11. Is the use of alternative therapy in children just another form of medicalisation? A prospective study.

Author

Ventura, Giovanna, Battistuz, Elena, Posocco, Francesca, Cossovel, Francesca, Ghirardo, Sergio, Barbi, Egidio, and Cozzi, Giorgio

Subjects
*SOCIAL status, *LONGITUDINAL method, *DEMOGRAPHIC characteristics, *HIGH-income countries, *ADULT-child relationships, *ALTERNATIVE medicine, *PARENTS
Abstract

Aim: The use of complementary and alternative medicines (CAM) seems widespread in adults and children, despite the conflicting evidence regarding its effectiveness and safety. This study aims to investigate the prevalence of the use of CAM in a population of Italian children.Methods: This is a prospective observational study conducted in 4 family paediatric clinics, in Friuli Venezia Giulia, Italy, from February to June 2019. Children were enrolled after being visited. The use of CAM and essential therapies (ET) in the previous year was investigated with an anonymous questionnaire. The demographic characteristics of children and families were also collected.Results: Six hundred children were enrolled, mean age 5.8 years, 50% females. In the previous year, 358 (60%) children used both essential therapies and CAM, 209 children (35%) only essential therapies, 25 (4%) only CAM, and 8 (1%) no therapy. CAM was more frequently used in children whose parents have a higher educational level and come from high-income countries (P < .0001). Non-vaccinated children received more CAM than vaccinated ones (P < .003).Conclusion: In our population, more than 60% of children receive CAM. The use of this medical approach seems strictly related to the social and cultural status of families. [ABSTRACT FROM AUTHOR]

Published
2021
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12. L'ecografia nella diagnostica delle fratture: Una revisione della letteratura, la nostra esperienza, la possibile applicazione

Author

Ghirardo, Sergio, Neri, Elena, Rabach, Ingrid, Ventura, Giovanna, Guastalla, Veronica, Guastalla, Pierpaolo, Ventura, Alessandro, Barbi, Egidio, Ghirardo, Sergio, Neri, Elena, Rabach, Ingrid, Ventura, Giovanna, Guastalla, Veronica, Guastalla, Pierpaolo, Ventura, Alessandro, and Barbi, Egidio

Subjects
Hand and fingers fractures, Emergency department, Children, Diagnosis, Ultrasonography, Pediatrics, Perinatology and Child Health, Hand and fingers fracture, Perinatology and Child Health, Pediatrics, Diagnosi
Abstract

In the emergency room the current management of the patient with suspected fracture involves a physical examination of the damaged area, an examination by the specialist and the performance of radiographic projections depending on the clinical suspicion. Analyzing the literature, there is evidence that the ultrasound method can be useful to perform an assessment of the first instance. In fact, the ultrasound diagnosis of fractures is now a method that, if performed by trained staff (also in a short time), has a good specificity and sensitivity. So, it could be performed as a first approach to trauma with suspected fracture, before the specialist examination. The paper highlights that ultrasound, performed by the radiologist, or by a paediatrician after a short specific training, presents good sensitivity and specificity in the diagnosis of fractures of the hands and fingers.

Published
2015

15. Children under 5 years are at risk for tuberculosis after occasional contact with highly contagious patients: outbreak from a smear-positive healthcare worker

Author

Luzzati, Roberto, primary, Migliori, Giovanni Battista, additional, Zignol, Matteo, additional, Cirillo, Daniela Maria, additional, Maschio, Massimo, additional, Tominz, Riccardo, additional, Ventura, Giovanna, additional, Patussi, Valentino, additional, D'Ambrosio, Lia, additional, Centis, Rosella, additional, Michieletto, Franco, additional, Trovato, Alberto, additional, Salton, Francesco, additional, Busetti, Marina, additional, Di Santolo, Manuela, additional, Raviglione, Mario, additional, and Confalonieri, Marco, additional

Published
2017
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17. Aftosi orale ricorrente: una, nessuna, centomila

Author

Tornese, Gianluca, L'Erario, Ines, Lepore, Loredana, Ventura, Giovanna, Marchetti, Federico, Ventura, Alessandro, Tornese, Gianluca, L'Erario, Ine, Lepore, Loredana, Ventura, Giovanna, Marchetti, Federico, and Ventura, Alessandro

Subjects
Oral ulcer, Differential diagnosi, Aphthae, Canker sore, Differential diagnosis, Management, Primary care
Abstract

Recurrent aphthous stomatitis (RAS) (also referred as aphthae or canker sores) is a common disorder affecting up to 60-70% of the general population at any time. Usually, RAS is a well-defined clinical condition (recurrent painful ulcers confined to the mouth, in the absence of systemic disease, with spontaneous resolution in few days) and as a rule it is easily recognized (and accepted as paraphysiological) by the patient. Nevertheless, other aphthous lesions may resemble but are different from RAS. Additional clinical signs (i.e. fever) should be valued since they lead to exclude RAS by definition and impose to suspect some other disorders. This article proposes a review of the etiopathogenesis, differential diagnosis and management of RAS in primary care.

Published
2008

19. Outcome of childhood-onset full-house nephropathy

Author

Ruggiero, Barbara, primary, Vivarelli, Marina, additional, Gianviti, Alessandra, additional, Pecoraro, Carmine, additional, Peruzzi, Licia, additional, Benetti, Elisa, additional, Ventura, Giovanna, additional, Pennesi, Marco, additional, Murer, Luisa, additional, Coppo, Rosanna, additional, and Emma, Francesco, additional

Published
2016
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21. Multicentre survey to explore current survival of patients with acute myeloid leukaemia who failed induction chemotherapy

Author

Lazzarotto, Davide, primary, Candoni, Anna, additional, Nadali, Gianpaolo, additional, Pavan, Laura, additional, Lessi, Federica, additional, Mosna, Federico, additional, Simeone, Erica, additional, Ventura, Giovanna, additional, Gherlinzoni, Filippo, additional, Semenzato, Gianpietro, additional, Pizzolo, Giovanni, additional, and Fanin, Renato, additional

Published
2015
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23. Outcome of childhood-onset full-house nephropathy.

Author

Ruggiero, Barbara, Vivarelli, Marina, Gianviti, Alessandra, Pecoraro, Carmine, Peruzzi, Licia, Benetti, Elisa, Ventura, Giovanna, Pennesi, Marco, Murer, Luisa, Coppo, Rosanna, and Emma, Francesco

Subjects
KIDNEY diseases, KIDNEY disease treatments, LUPUS nephritis, JUVENILE diseases, BIOPSY, PATIENTS
Abstract

Background: Patients with full-house nephropathy (FHN) present renal lesions that are indistinguishable from those of lupus nephritis (LN) but lack the systemic features necessary to meet diagnostic criteria for systemic lupus erithematosus (SLE). Some have been reported to develop a delayed SLE with time. The clinical outcome of children having FHN without SLE has never been reported. Methods: Children with biopsy-proven FHN were selected after excluding SLE cases by the absence of America College of Rheumatology criteria. The proportion of patients with complete (proteinuria <0.5 g/day) or partial remission (proteinuria ≤50% from baseline), relapse (estimated glomerular filtration rate <25% and/or proteinuria ≥50% from baseline) and progression to Stage III chronic kidney disease (CKD) was described according to age and gender groups with the Kaplan-Meier curve and compared with the Log-rank test. Entity of treatment was summarized by a score at induction (0-6 months) and maintenance (6-18 months). Cox-regression model was performed to test predictors of remission, relapse and progression to CKD. Results: Among 42 patients (28 pre-pubertal) who met the inclusion criteria, 39 (92.9%) achieved partial and 32 (76.2%) complete remission of nephropathy over 2.78 and 7.51 months of follow-up. At 10 years, the probability of progressing to CKD was 4.8%. Of those achieving remission, 18% had a renal flare mainly within 4 years after remission. Pre-pubertal males achieved complete remission more frequently than other patients but often relapsed; pre-pubertal females were treated more aggressively. Cox-regression analysis did not find independent predictors of remission or relapse. Conclusions: The outcome of the patients with FHN we investigated was encouraging. Recurrences are limited to the first 4 years following diagnosis, allowing progressive withdrawal of immunosuppression in patients achieving remission. Evaluation of risk factors for adverse outcome is necessary especially in pre-pubertal children. [ABSTRACT FROM AUTHOR]

Published
2017
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24. Azacitidine As Post-Remission Therapy in Elderly Patients with Acute Myeloid Leukemia Significantly Prolongs Disease-Free Survival: Interim Results from a Prospective, Randomized, Open-Label, Phase III Multicenter Trial

Author

Oliva, Esther Natalie, primary, Alati, Caterina, additional, Salutari, Prassede, additional, Freyrie, Alessandra, additional, Candoni, Anna, additional, Simeone, Erica, additional, Ventura, Giovanna, additional, Cortelezzi, Agostino, additional, Capelli, Debora, additional, Leoni, Pietro, additional, Di Bartolomeo, Paolo, additional, Marino, Antonio Giovanni, additional, Cufari, Patrizia, additional, Di Raimondo, Francesco, additional, Mauro, Elisa, additional, Volpe, Antonio, additional, Cascavilla, Nicola, additional, Musto, Pellegrino, additional, Morabito, Fortunato, additional, Niscola, Pasquale, additional, Specchia, Giorgina, additional, and Ronco, Francesca, additional

Published
2014
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25. Leonardo da Vinci Meets Celiac Disease

Author

Zanchi, Chiara, primary, Ventura, Giovanna, additional, Di Leo, Grazia, additional, Orzes, Nicoletta, additional, Ronfani, Luca, additional, Not, Tarcisio, additional, and Ventura, Alessandro, additional

Published
2013
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30. Is the use of alternative therapy in children just another form of medicalisation? A prospective study

Author

Francesca Cossovel, Francesca Posocco, Elena Battistuz, Giovanna Ventura, Giorgio Cozzi, Sergio Ghirardo, Egidio Barbi, Ventura, Giovanna, Battistuz, Elena, Posocco, Francesca, Cossovel, Francesca, Ghirardo, Sergio, Barbi, Egidio, and Cozzi, Giorgio

Subjects
Adult, Complementary Therapies, Male, Parents, medicine.medical_specialty, Alternative therapy, Population, 03 medical and health sciences, 0302 clinical medicine, children, medicalisation, 030225 pediatrics, Medicalization, Surveys and Questionnaires, medicine, complementary and alternative therapy, Humans, 030212 general & internal medicine, Prospective Studies, education, Prospective cohort study, Child, education.field_of_study, essential therapy, maternal education, business.industry, Mean age, General Medicine, Friuli venezia giulia, Maternal education, Italy, Family medicine, Child, Preschool, Pediatrics, Perinatology and Child Health, Observational study, Female, business
Abstract

AIM The use of complementary and alternative medicines (CAM) seems widespread in adults and children, despite the conflicting evidence regarding its effectiveness and safety. This study aims to investigate the prevalence of the use of CAM in a population of Italian children. METHODS This is a prospective observational study conducted in 4 family paediatric clinics, in Friuli Venezia Giulia, Italy, from February to June 2019. Children were enrolled after being visited. The use of CAM and essential therapies (ET) in the previous year was investigated with an anonymous questionnaire. The demographic characteristics of children and families were also collected. RESULTS Six hundred children were enrolled, mean age 5.8 years, 50% females. In the previous year, 358 (60%) children used both essential therapies and CAM, 209 children (35%) only essential therapies, 25 (4%) only CAM, and 8 (1%) no therapy. CAM was more frequently used in children whose parents have a higher educational level and come from high-income countries (P

Published
2021

31. La scelta d'ignorare, essere indifferenti e dimenticare. La concezione di responsabilità in Verità e esistenza di Jean-Paul Sartre

Author

Maria Russo, Francesco Miano, Laura Boella, Piergiorgio Donatelli, Luca Fonnesu, Giulia Battistoni, Omar Brino, Paolo Scolari, Loreta Risio, Maria Russo, Lorella Ventura, Giovanna Costanzo, Ivo De Gennario, Ralf Lufter, Vittoria Franco, Cristoph Lumer, Orietta Ombrosi, Alice Pugliese, Stefano Biancu, Veronica Neri, Igor Pelgreffi, Sarah Songhorian, Consuelo Luverà, Francesca Marin, Valentina Pastorelli, Aurelio Rizzacasa, Virginia Sanchini, Maria Silvia Vaccarezza, Agnes Heller, Rossella Bonito Oliva, Benedetta Giovanola, Roberto Mordacci, Francesco Miano, and Russo, Maria

Subjects
Sartre, responsabilità, libertà, autenticità, verità, opinione
Published
2018

32. Three years of KAMUT® khorasan production: yield and grain quality parameters

Author

Giovanni Dinelli, Alessandro Di Loreto, Valeria Bregola, Ilaria Marotti, Rocco Enrico Sferrazza, Sara Bosi, Francesca Ventura, Giovanna Seddaiu, Gabriele Cola, Giovanni, Dinelli, Alessandro Di Loreto, Valeria, Bregola, Ilaria, Marotti, Rocco Enrico Sferrazza, and Sara, Bosi

Subjects
quality maps, quality trait, Triticum turgidum spp. Turanicum, food and beverages, yield
Abstract

The increasing interest in organic food products and in particular in the functional food sector, has emphasised the importance of investigate the relationship between growing environmental conditions of wheat, agronomic traits and quality parameters of grain. Therefore, the aim of this study was to evaluate the nutrient/nutraceutical composition of KAMUT® khorasan wheat and its agronomic quality profile in relation with growing location. The research underlined the strong influence of the environmental factors on crop productivity and quality, in terms of nutritional and nutraceutical value.

Published
2017

33. Nonatopic persistent asthma in children, a missed phenotype of asthma?

Author

Elisa Panontin, Giovanna Ventura, Ester Conversano, Giorgio Longo, Alessandro Ventura, Longo, Giorgio, Conversano, Ester, Panontin, Elisa, Ventura, Giovanna, and Ventura, Alessandro

Subjects
0301 basic medicine, business.industry, Immunology, MEDLINE, medicine.disease, Phenotype, Nonatopic asthma, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030228 respiratory system, medicine, Immunology and Allergy, Persistent asthma, business, Asthma
Abstract

N/A

Published
2017

34. Wheat spatial variation based on spectral vegetation indices and soil analysis

Author

Lorenzo Barbanti, Josep Adroher, Júnior Melo Damian, Nicola Di Virgilio, Gloria Falsone, Matteo Zucchelli, Roberta Martelli, Francesca Ventura, Giovanna Seddaiu, Gabriele Cola, Lorenzo, Barbanti, Josep, Adroher, Júnior Melo Damian, Nicola Di Virgilio, Gloria, Falsone, Matteo, Zucchelli, and Roberta, Martelli

Subjects
Homogeneous areas, soil properties, remote vegetation indices, wheat, yield mapping
Abstract

Soil characteristics, proximal and remote spectral vegetation indices were geo-referentially assessed in a 4.15 ha wheat field in northern Italy. Data obtained in the three separate domains were submitted to principal component analysis (PCA), and the retained PCs were clustered to delineate homogeneous areas at low (L), intermediate (I) and high (H) potential, based on soil parameters (CLUsp), proximal (CLUpi) and remote spectral vegetation indices (CLUri). Spatial distribution of soil and crop data showed a low performing area (GY < 3 Mg ha-1) and a high performing one (GY > 8 Mg ha-1). CLUsp staged a lower GY difference between L and H area (60%) than CLUpi and CLUri (ca. 100%). Area levels (L, I, H) based on vegetation indices outlined a better degree of agreement with GY, compared to area levels based on soil parameters. In exchange for this, the above referred soil parameters are quite consistent in time, allowing soil data to be used for more crop seasons.

Published
2017

35. Children under 5 years are at risk for tuberculosis after occasional contact with highly contagious patients: outbreak from a smear-positive healthcare worker

Author

Matteo Zignol, Massimo Maschio, Valentino Patussi, Rosella Centis, Lia D'Ambrosio, Riccardo Tominz, Manuela Di Santolo, Marina Busetti, Alberto Trovato, Mario C. Raviglione, Marco Confalonieri, Daniela Maria Cirillo, Roberto Luzzati, Giovanni Battista Migliori, Franco Michieletto, Giovanna Ventura, Francesco Salton, Luzzati, Roberto, Migliori, Giovanni Battista, Zignol, Matteo, Cirillo, Daniela Maria, Maschio, Massimo, Tominz, Riccardo, Ventura, Giovanna, Patussi, Valentino, D'Ambrosio, Lia, Centis, Rosella, Michieletto, Franco, Trovato, Alberto, Salton, Francesco, Busetti, Marina, Di Santolo, Manuela, Raviglione, Mario, and Confalonieri, Marco

Subjects
Male, Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Health Personnel, Disease Outbreaks, 03 medical and health sciences, Health personnel, 0302 clinical medicine, children, Latent Tuberculosis, medicine, risk factors, Humans, 030212 general & internal medicine, tuberculosi, Tuberculin test, tuberculosis, outbreak, Latent tuberculosis, Tuberculin Test, business.industry, Infant, Newborn, Infant, Outbreak, Healthcare worker, Middle Aged, medicine.disease, Infant newborn, Italy, 030228 respiratory system, risk factor, Child, Preschool, Female, Contact Tracing, business, Contact tracing
Abstract

Children under 5 years of age are at risk for tuberculosis after occasional contact with highly contagious patients http://ow.ly/RqAn30fKdGk

Published
2017

36. Computed Tomography for Suspected Appendicitis in Children: Do Not Forget Radiation Exposure

Author

Giorgio Cozzi, Giovanna Ventura, Egidio Barbi, Cozzi, Giorgio, Ventura, Giovanna, and Barbi, Egidio

Subjects
Male, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Contrast Media, Computed tomography, General Medicine, Perinatology and Child Health, Appendix, Appendicitis, Pediatrics, Radiation exposure, Female, Humans, Multidetector Computed Tomography, Pediatrics, Perinatology and Child Health, Emergency Medicine, medicine, Appendiciti, Suspected appendicitis, Radiology, business, Human
Abstract

Not applicable

Published
2015

37. Extremely large air distension of the bowel

Author

Alessandro Ventura, Giovanna Ventura, Matteo Pavan, Massimo Maschio, Pavan, Matteo, Ventura, Giovanna, Maschio, Massimo, and Ventura, Alessandro

Subjects
medicine.medical_specialty, Constipation, Acute constipation, Adolescent, medicine.medical_treatment, Biopsy, Rectum, Distension, Gastroenterology, Ileostomy, Internal medicine, medicine, Humans, Hirschsprung Disease, Intestine, Large, Chronic constipation, business.industry, Air, General Medicine, Abdominal distension, Radiography, Parenteral nutrition, medicine.anatomical_structure, intestinal pseudobstruction, Female, medicine.symptom, business
Abstract

A 14-year-old girl presented to our paediatric department in May, 2012, with massive abdominal distension that had developed over the previous 2 years. She reported chronic abdominal discomfort, alternating diarrhoea and constipation, and two previous subocclusive episodes that had resolved with laxative therapy. Plain abdominal radiographs showed substantial large bowel distension and several air–fl uid levels. No air was evident in the rectum or anal canal (fi gure). She underwent surgery, and because no mechanical obstruction was observed a diverting ileostomy was done. Analysis of full-thickness large bowel and rectal biopsy samples obtained during surgery showed a decreased number of ganglion cells and acetylcho linesterase activity compatible with the diagnosis of hypo ganglionosis. In November, 2012, she had large bowel resection, ileorectal anastomosis, and ileostomy repositioning. The postoperative course was character ised by progressive intestinal recanalisation, although she had persistent watery stools with faecal sodium loss. The resulting electrolyte imbalance was corrected with partial parenteral nutrition. The patient was discharged 2 months after the procedure and continued parenteral nutrition at home. She had a gradual reduction of watery diarrhoea so we tapered the partial parenteral nutrition and weaning was possible after 12 months. At last follow-up in July, 2014, the patient reported no more episodes of abdominal distension. Hypoganglionosis is classed as a hypogenetic type of intestinal innervation disorder characterised by very low or absent acetylcholinesterase mucosal activity and a decreased number of ganglion cells within the myenteric and submucosal plexus of a variable intestinal segment. The most common presenting symptoms of hypoganglionosis are acute constipation, intestinal obstruction, and enterocolitis. The disorder thus resembles Hirschsprung’s disease, but clinical pre sentation might be subtle and misdiagnosed as chronic constipation. The median age at diagnosis is usually higher in patients with hypoganglionosis than Hirschsprung’s disease. Defi nitive diagnosis requires the analysis of full-thickness biopsy sample of the aff ected intestinal segment. The treatment is surgical, involving resection of the hypoganglionotic tract of the intestine.

Published
2015

38. Orofacial granulomatosis in children: Think about Crohn's disease

Author

Chiara Bersanini, Giovanna Zuin, Andrea Taddio, Stefano Martelossi, Giovanna Ventura, Massimo Fontana, Alessandro Ventura, Marzia Lazzerini, Gabriele Cont, Lazzerini, Marzia, Martelossi, Stefano, Cont, Gabriele, Bersanini, Chiara, Ventura, Giovanna, Fontana, Massimo, Zuin, Giovanna, Ventura, Alessandro, and Taddio, Andrea

Subjects
Male, medicine.medical_specialty, Pathology, Adolescent, Biopsy, Disease, Lip swelling, Diagnosis, Differential, Crohn Disease, Internal medicine, Melkersson–Rosenthal syndrome, Medicine, Humans, Granulomatosis, Orofacial, Child, Orofacial granulomatosis, Crohn's disease, Hepatology, business.industry, Orofacial granulomatosi, Gastroenterology, Melkersson-Rosenthal syndrome, Colonoscopy, medicine.disease, Dermatology, Thalidomide, Concomitant, Female, business, Immunosuppressive Agents, medicine.drug
Abstract

Background The term orofacial granulomatosis is conventionally used to describe patients with granulomatous lesions affecting the orofacial tissues, in absence of intestinal lesions. Lip swelling and facial swelling are the most common clinical signs. Despite the fact that histologically it is not distinguishable from Crohn's disease, and that both diseases have a chronic/recurrent course, the relationship between orofacial granulomatosis and Crohn's disease is still debated. Methods Herein we present five cases of orofacial granulomatosis. Results All patients presented concomitant Crohn's disease, supporting the hypothesis that orofacial granulomatosis and Crohn's disease may be one single disease. Thalidomide was effective in inducing remission of oral and intestinal symptoms in all five cases and could be considered a valid treatment opportunity for these patients. Conclusions Orofacial granulomatosis and Crohn's disease may be part of the same disease; both may respond to thalidomide.

Published
2015

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