6,874 results on '"Verani A"'
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2. An Immersed Boundary Method for Polymeric Continuous Mixing
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Negrini, G., Parolini, N., and Verani, M.
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Mathematics - Numerical Analysis ,65M50 - Abstract
We introduce a new implementation of the Immersed Boundary method in the finite-volume library OpenFOAM. The implementation is tailored to the simulation of temperature-dependent non-Newtonian polymeric flows in complex moving geometries, such as those characterizing the most popular polymeric mixing technologies., Comment: 16 pages, 11 figures
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- 2024
3. A posteriori error analysis for a coupled Stokes-poroelastic system with multiple compartments
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Fumagalli, Ivan, Parolini, Nicola, and Verani, Marco
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Mathematics - Numerical Analysis ,65N15, 65N22, 65N30, 76Z05 ,G.1.8 ,J.2 ,J.3 - Abstract
The discretization of fluid-poromechanics systems is typically highly demanding in terms of computational effort. This is particularly true for models of multiphysics flows in the brain, due to the geometrical complexity of the cerebral anatomy - requiring a very fine computational mesh for finite element discretization - and to the high number of variables involved. Indeed, this kind of problems can be modeled by a coupled system encompassing the Stokes equations for the cerebrospinal fluid in the brain ventricles and Multiple-network Poro-Elasticity (MPE) equations describing the brain tissue, the interstitial fluid, and the blood vascular networks at different space scales. The present work aims to rigorously derive a posteriori error estimates for the coupled Stokes-MPE problem, as a first step towards the design of adaptive refinement strategies or reduced order models to decrease the computational demand of the problem. Through numerical experiments, we verify the reliability and optimal efficiency of the proposed a posteriori estimator and identify the role of the different solution variables in its composition., Comment: 23 pages, 3 figures
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- 2024
4. Learning epidemic trajectories through Kernel Operator Learning: from modelling to optimal control
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Ziarelli, Giovanni, Parolini, Nicola, and Verani, Marco
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Mathematics - Numerical Analysis ,Computer Science - Machine Learning ,Mathematics - Optimization and Control ,Quantitative Biology - Populations and Evolution - Abstract
Since infectious pathogens start spreading into a susceptible population, mathematical models can provide policy makers with reliable forecasts and scenario analyses, which can be concretely implemented or solely consulted. In these complex epidemiological scenarios, machine learning architectures can play an important role, since they directly reconstruct data-driven models circumventing the specific modelling choices and the parameter calibration, typical of classical compartmental models. In this work, we discuss the efficacy of Kernel Operator Learning (KOL) to reconstruct population dynamics during epidemic outbreaks, where the transmission rate is ruled by an input strategy. In particular, we introduce two surrogate models, named KOL-m and KOL-$\partial$, which reconstruct in two different ways the evolution of the epidemics. Moreover, we evaluate the generalization performances of the two approaches with different kernels, including the Neural Tangent Kernels, and compare them with a classical neural network model learning method. Employing synthetic but semi-realistic data, we show how the two introduced approaches are suitable for realizing fast and robust forecasts and scenario analyses, and how these approaches are competitive for determining optimal intervention strategies with respect to specific performance measures., Comment: 38 pages, 13 figures
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- 2024
5. A Virtual Element method for non-Newtonian fluid flows
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Antonietti, P. F., da Veiga, L. Beirao, Botti, M., Vacca, G., and Verani, M.
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Mathematics - Numerical Analysis - Abstract
In this paper, we design and analyze a Virtual Element discretization for the steady motion of non-Newtonian, incompressible fluids. A specific stabilization, tailored to mimic the monotonicity and boundedness properties of the continuous operator, is introduced and theoretically investigated. The proposed method has several appealing features, including the exact enforcement of the divergence free condition and the possibility of making use of fully general polygonal meshes. A complete well-posedness and convergence analysis of the proposed method is presented under mild assumptions on the non-linear laws, encompassing common examples such as the Carreau--Yasuda model. Numerical experiments validating the theoretical bounds as well as demonstrating the practical capabilities of the proposed formulation are presented.
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- 2024
6. Experimental Evaluation of Nano-material and Biopolymer Additives on Expansive Subgrade Soil for Pavement Applications
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Sanniyah, Salwa Siti, Sihombing, Atmy Verani Rouly, Mase, Lindung Zalbuin, Susanto, Ambar, Somantri, Andri Krisnandi, and Krisologus, Yulianto Petrus
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- 2024
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7. Adsorption of brilliant cresyl blue from aqueous solution by silver nanoparticles on zinc oxide
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Tinoco, Julián López, Muñoz Villegas, Luis Fernando, Sánchez, Verani Izamara Yépez, Perez, Francisco Augusto Nuñez, and Rodriguez, Jose Manuel Zapien
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- 2024
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8. Level set-fitted polytopal meshes with application to structural topology optimization
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Ferro, Nicola, Micheletti, Stefano, Parolini, Nicola, Perotto, Simona, Verani, Marco, and Antonietti, Paola Francesca
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Computer Science - Computational Engineering, Finance, and Science - Abstract
We propose a method to modify a polygonal mesh in order to fit the zero-isoline of a level set function by extending a standard body-fitted strategy to a tessellation with arbitrarily-shaped elements. The novel level set-fitted approach, in combination with a Discontinuous Galerkin finite element approximation, provides an ideal setting to model physical problems characterized by embedded or evolving complex geometries, since it allows skipping any mesh post-processing in terms of grid quality. The proposed methodology is firstly assessed on the linear elasticity equation, by verifying the approximation capability of the level set-fitted approach when dealing with configurations with heterogeneous material properties. Successively, we combine the level set-fitted methodology with a minimum compliance topology optimization technique, in order to deliver optimized layouts exhibiting crisp boundaries and reliable mechanical performances. An extensive numerical test campaign confirms the effectiveness of the proposed method.
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- 2023
9. Iterative solution to the biharmonic equation in mixed form discretized by the Hybrid High-Order method
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Antonietti, Paola F., Matalon, Pierre, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
We consider the solution to the biharmonic equation in mixed form discretized by the Hybrid High-Order (HHO) methods. The two resulting second-order elliptic problems can be decoupled via the introduction of a new unknown, corresponding to the boundary value of the solution of the first Laplacian problem. This technique yields a global linear problem that can be solved iteratively via a Krylov-type method. More precisely, at each iteration of the scheme, two second-order elliptic problems have to be solved, and a normal derivative on the boundary has to be computed. In this work, we specialize this scheme for the HHO discretization. To this aim, an explicit technique to compute the discrete normal derivative of an HHO solution of a Laplacian problem is proposed. Moreover, we show that the resulting discrete scheme is well-posed. Finally, a new preconditioner is designed to speed up the convergence of the Krylov method. Numerical experiments assessing the performance of the proposed iterative algorithm on both two- and three-dimensional test cases are presented.
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- 2023
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10. The Rhie-Chow stabilized Box Method for the Stokes problem
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Negrini, G., Parolini, N., and Verani, M.
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Mathematics - Numerical Analysis ,65N08 ,G.1.8 - Abstract
The Finite Volume method (FVM) is widely adopted in many different applications because of its built-in conservation properties, its ability to deal with arbitrary mesh and its computational efficiency. In this work, we consider the Rhie-Chow stabilized Box Method (RCBM) for the approximation of the Stokes problem. The Box Method (BM) is a piecewise linear Petrov-Galerkin formulation on the Voronoi dual mesh of a Delaunay triangulation, whereas the Rhie-Chow (RC) stabilization is a well known stabilization technique for FVM. The first part of the paper provides a variational formulation of the RC stabilization and discusses the validity of crucial properties relevant for the well-posedeness and convergence of RCBM. Moreover, a numerical exploration of the convergence properties of the method on 2D and 3D test cases is presented. The last part of the paper considers the theoretically justification of the well-posedeness of RCBM and the experimentally observed convergence rates. This latter justification hinges upon suitable assumptions, whose validity is numerically explored., Comment: 27 pages, 6 figures, 4 tables
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- 2023
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11. Comparison of Lithium-Ion Battery SoC Estimation Accuracy of LSTM Neural Network Trained with Experimental and Synthetic Datasets
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Hattouti, Luca Amyn, Di Rienzo, Roberto, Nicodemo, Niccolò, Verani, Alessandro, Baronti, Federico, Roncella, Roberto, Saletti, Roberto, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Bellotti, Francesco, editor, Grammatikakis, Miltos D., editor, Mansour, Ali, editor, Ruo Roch, Massimo, editor, Seepold, Ralf, editor, Solanas, Agusti, editor, and Berta, Riccardo, editor
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- 2024
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12. Novel Battery Parallelization Approach Using DC/DC Partial Power Converter in Micro-Grids
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Simonte, Gianluca, Di Rienzo, Roberto, Nicodemo, Niccolò, Verani, Alessandro, Baronti, Federico, Roncella, Roberto, Saletti, Roberto, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Bellotti, Francesco, editor, Grammatikakis, Miltos D., editor, Mansour, Ali, editor, Ruo Roch, Massimo, editor, Seepold, Ralf, editor, Solanas, Agusti, editor, and Berta, Riccardo, editor
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- 2024
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13. Low-Cost Configurable Electronic Load for Lithium Ion Batteries Testing
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Nicodemo, Niccolò, Di Rienzo, Roberto, Verani, Alessandro, Baronti, Federico, Roncella, Roberto, Saletti, Roberto, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Bellotti, Francesco, editor, Grammatikakis, Miltos D., editor, Mansour, Ali, editor, Ruo Roch, Massimo, editor, Seepold, Ralf, editor, Solanas, Agusti, editor, and Berta, Riccardo, editor
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- 2024
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14. Risk factors of adverse birth outcomes among a cohort of pregnant women in Coastal Kenya, 2017–2019
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Mirieri, Harriet, Nduati, Ruth, Dawa, Jeanette, Okutoyi, Lydia, Osoro, Eric, Mugo, Cyrus, Wamalwa, Dalton, Jin, Hafsa, Mwaengo, Dufton, Otieno, Nancy, Marwanga, Doris, Shabibi, Mufida, Munyua, Peninah, Kinuthia, John, Clancey, Erin, Widdowson, Marc-Alain, Njenga, M. Kariuki, Verani, Jennifer R., and Inwani, Irene
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- 2024
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15. Critical Needs for Integrated Surveillance: Wastewater-Based and Clinical Epidemiology in Evolving Scenarios with Lessons Learned from SARS-CoV-2
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Carducci, Annalaura, Federigi, Ileana, Lauretani, Giulia, Muzio, Sara, Pagani, Alessandra, Atomsa, Nebiyu Tariku, and Verani, Marco
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- 2024
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16. A DG-VEM method for the dissipative wave equation
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Antonietti, Paola Francesca, Bonizzoni, Francesca, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
A novel space-time discretization for the (linear) scalar-valued dissipative wave equation is presented. It is a structured approach, namely, the discretization space is obtained tensorizing the Virtual Element (VE) discretization in space with the Discontinuous Galerkin (DG) method in time. As such, it combines the advantages of both the VE and the DG methods. The proposed scheme is implicit and it is proved to be unconditionally stable and accurate in space and time.
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- 2023
17. Adaptive VEM for variable data: convergence and optimality
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da Veiga, L. Beirão, Canuto, C., Nochetto, R. H., Vacca, G., and Verani, M.
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Mathematics - Numerical Analysis - Abstract
We design an adaptive virtual element method (AVEM) of lowest order over triangular meshes with hanging nodes in 2d, which are treated as polygons. AVEM hinges on the stabilization-free a posteriori error estimators recently derived in [8]. The crucial property, that also plays a central role in this paper, is that the stabilization term can be made arbitrarily small relative to the a posteriori error estimators upon increasing the stabilization parameter. Our AVEM concatenates two modules, GALERKIN and DATA. The former deals with piecewise constant data and is shown in [8] to be a contraction between consecutive iterates. The latter approximates general data by piecewise constants to a desired accuracy. AVEM is shown to be convergent and quasi-optimal, in terms of error decay versus degrees of freedom, for solutions and data belonging to appropriate approximation classes. Numerical experiments illustrate the interplay between these two modules and provide computational evidence of optimality.
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- 2023
18. Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: an application to the Italian scenario
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Ziarelli, Giovanni, Dede', Luca, Parolini, Nicola, Verani, Marco, and Quarteroni, Alfio
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Mathematics - Optimization and Control ,Quantitative Biology - Populations and Evolution - Abstract
In the context of SARS-CoV-2 pandemic, mathematical modelling has played a fundamental role for making forecasts, simulating scenarios and evaluating the impact of preventive political, social and pharmaceutical measures. Optimal control theory can be a useful tool based on solid mathematical bases to plan the vaccination campaign in the direction of eradicating the pandemic as fast as possible. The aim of this work is to explore the optimal prioritisation order for planning vaccination campaigns able to achieve specific goals, as the reduction of the amount of infected, deceased and hospitalized in a fixed time frame, among age classes. For this purpose, we introduce an age stratified SIR-like epidemic compartmental model settled in an abstract framework for modelling two-doses vaccination campaigns and conceived with the description of COVID19 disease. Overall, we formalize an optimal control framework adopting the model as state problem by acting on the administrations of vaccine-doses. An extensive campaign of numerical tests, featured in the Italian scenario and calibrated on available data from Dipartimento di Protezione Civile Italiana, shows that the presented framework can be a valuable tool to support the planning of vaccination campaigns minimizing specific goals.
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- 2022
19. Review of the existing maximum residue levels for difenoconazole according to Article 12 of Regulation (EC) No 396/2005
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,difenoconazole ,fungicide ,MRL review ,regulation (EC) No 396/2005 ,triazole derivative metabolites ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance difenoconazole. To assess the occurrence of difenoconazole residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Council Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the European authorisations reported by Member States and the UK (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived, and a consumer risk assessment was carried out. Some information required by the regulatory framework was missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, some MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered.
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- 2024
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20. Modification of the existing maximum residue level for methoxyfenozide in aubergines
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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aubergines/eggplants ,consumer risk assessment ,methoxyfenozide ,MRL ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the Federal Public Service (FPS) Health, Food chain Safety and Environment submitted a request on behalf of Belgium (evaluating Member State, EMS) to modify the existing maximum residue level (MRL) for the active substance methoxyfenozide in aubergines/eggplants. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for aubergines/eggplants. Adequate analytical methods for enforcement are available to control the residues of methoxyfenozide in the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, the EFSA concluded that the short‐term and long‐term intake of residues resulting from the indoor use of methoxyfenozide according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2024
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21. Iterative solution to the biharmonic equation in mixed form discretized by the Hybrid High-Order method.
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Paola F. Antonietti, Pierre Matalon, and Marco Verani
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- 2024
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22. Level set-fitted polytopal meshes with application to structural topology optimization.
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Nicola Ferro 0002, Stefano Micheletti, Nicola Parolini, Simona Perotto, Marco Verani, and Paola Francesca Antonietti
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- 2024
- Full Text
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23. Open Hardware/Software Modular Battery Emulator for Battery Management Systems Development and Functional Testing.
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Alessandro Verani, Roberto Di Rienzo, Niccolò Nicodemo, Federico Baronti, Roberto Roncella, and Roberto Saletti
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- 2024
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24. Effect of biorejuvenator types on microstructure, mechanistic performance, and resilient modulus prediction model of asphalt concrete containing recycled materials in Indonesia
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Atmy Verani Rouly Sihombing, Bambang Sugeng Subagio, Eri Susanto Hariyadi, Agah Muhammad Mulyadi, Retno Utami, and Reza Phalevi Sihombing
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Biorejuvenator ,Bioasphalt ,Recycled Material ,Reclaimed Asphalt Pavement ,Asphalt Binder Film Thickness ,Microstructure ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Biorejuvenators are rejuvenating agents produced from sustainable biological raw materials. In this study, a biorejuvenator was used in recycled materials, such as reclaimed asphalt pavement (RAP), to determine its effect on the asphalt binder film thickness (ABFT) and resilient modulus (Smix) of an asphalt concrete wearing course (ACWC) mixture, which was tested at the optimum binder content (OBC). The ABFT was investigated using scanning electron microscopy and the Smix was determined from the asphalt mixture test using UMATTA at test temperatures of 20–40 °C. The asphalt mixture was prepared with RAP (0–30%), pen 60/70, aggregates, and two types of biorejuvenators, namely coconut shell bioasphalt (BioCS) and BitutechRAP (from trees). Furthermore, an Smix model was developed for each mixture type. The ABFT value obtained from the microstructural test results for each mixture corresponded with the minimum ABFT requirements for the adhesion criteria of the asphalt mixture, microstructurally demonstrating that the biorejuvenators worked well to restore the performance of 30%RAP in the ACWC mixture. Both types of biorejuvenators could activate the bitumen of the RAP (RA binder) because they could still produce Smix. The value of Smix produced from the RAP and BioCS mixture was greater than that produced from the RAP and BitutechRAP mixture. In the resulting Smix model, the influential volumetric parameters for ACWC + RAP + BioCS and ACWC + RAP + BitutechRAP were the voids in mineral aggregate and voids in asphalt, respectively. Based on the results of the microstructural, mechanistic, and Smix models, BioCS, as a local Indonesian biorejuvenator, has significant potential to rejuvenate recycled materials up to 30%.
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- 2024
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25. Risk factors of adverse birth outcomes among a cohort of pregnant women in Coastal Kenya, 2017–2019
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Harriet Mirieri, Ruth Nduati, Jeanette Dawa, Lydia Okutoyi, Eric Osoro, Cyrus Mugo, Dalton Wamalwa, Hafsa Jin, Dufton Mwaengo, Nancy Otieno, Doris Marwanga, Mufida Shabibi, Peninah Munyua, John Kinuthia, Erin Clancey, Marc-Alain Widdowson, M. Kariuki Njenga, Jennifer R. Verani, and Irene Inwani
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Adverse birth outcomes ,Preterm birth ,Small for gestational age ,Stillbirth ,Miscarriage ,Microcephaly ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Introduction Adverse birth outcomes particularly preterm births and congenital anomalies, are the leading causes of infant mortality globally, and the burden is highest in developing countries. We set out to determine the frequency of adverse birth outcomes and the risk factors associated with such outcomes in a cohort of pregnant women in Kenya. Methods From October 2017 to July 2019, pregnant women
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- 2024
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26. Virtual Element Method for the Navier--Stokes Equation coupled with the Heat Equation
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Antonietti, Paola Francesca, Vacca, Giuseppe, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
We consider the Virtual Element discretization of the Navier-Stokes equations coupled with the heat equation where the viscosity depends on the temperature. We present the Virtual Element discretization of the coupled problem, show its well-posedness, and prove optimal error estimates. Numerical experiments which confirm the theoretical error bounds are also presented.
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- 2022
27. Modification of the existing maximum residue levels in various plant commodities resulting from the use of potassium phosphonates
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,MRL ,pesticide ,phosphonic acid ,potassium phosphonates ,various crops ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants De Sangosse SAS and Tilco‐Alginure submitted two requests, respectively, to the competent national authorities in France and Germany to modify the existing maximum residue levels (MRLs) for the active substance potassium phosphonates in various plant commodities. The data submitted in support of the requests were found to be sufficient to derive MRL proposals for the commodities under assessment. For the derived MRL on baby leaf crops, further risk manager consideration is required to decide between two MRL options. Adequate analytical methods for enforcement are available to control the residues of potassium phosphonates in accordance with the residue definition ‘phosphonic acid and its salts expressed as phosphonic acid’ in the commodities under consideration. Based on the risk assessment results and assuming that the existing MRLs will be amended as proposed by EFSA in previous outputs, EFSA concluded that the long‐term intake of residues resulting from the existing uses of fosetyl and phosphonates (previously assessed in a joint MRL review) and new proposed uses of potassium phosphonates is unlikely to present a risk to consumer health. Considering the toxicological profile of the active substance, a short‐term dietary risk assessment was not required. The risk assessment shall be regarded as indicative because some MRL proposals derived by EFSA in the framework of the MRL review according to Articles 12 and 43 of Regulation (EC) No 396/2005 require further consideration by risk managers.
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- 2024
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28. Review of the existing maximum residue levels for gamma‐cyhalothrin according to Article 12 of Regulation (EC) No 396/2005
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,gamma‐cyhalothrin ,insecticide ,MRL review ,pyrethroids ,Regulation (EC) No 396/2005 ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance gamma‐cyhalothrin. To assess the occurrence of gamma‐cyhalothrin residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU) No 188/2011, as well as the European authorisations reported by Member States (including the supporting residues data) in the framework of this review. Based on the assessment of the available data, MRL proposals were derived, and a consumer risk assessment was carried out. Although no risk to consumers was identified, some information required by the regulatory framework was missing. The residue definition for monitoring (lambda‐cyhalothrin (includes gamma‐cyhalothrin) (sum of R, S and S, R isomers)) covers both lambda‐ and gamma‐cyhalothrin. Appropriate enantioselective techniques, which are not commonly used in routine analysis, are required to differentiate gamma‐cyhalothrin residues from lambda‐cyhalothrin. According to the available data, it is expected that the MRLs currently set in Regulation (EC) No 396/2005 will cover the uses of gamma‐cyhalothrin assessed in the present review. Therefore, risk managers can consider maintaining the existing EU MRLs.
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- 2024
- Full Text
- View/download PDF
29. Evaluation of confirmatory data following the Article 12 MRL review for myclobutanil
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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confirmatory data ,MRL review ,pesticide ,risk assessment ,TDMs ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Corteva Agriscience submitted a request to the competent national authority in Austria to evaluate the confirmatory data that were identified for myclobutanil in the framework of the MRL review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gap related to the lack of information on the triazole derivative metabolites (TDMs), new residue trials analysing for TDMs were submitted on apples, grapes, strawberries, tomatoes and melons. Following the assessment of the submitted data, EFSA concluded that Article 12 confirmatory data gaps are considered addressed for pome fruits, grapes, cucurbits with inedible peel, strawberries and tomatoes. The new information provided required the assessment of consumer exposure to TDMs, which identified no consumer intake concerns for the crops under consideration. No information was provided to address the Article 12 confirmatory data referred to in Regulation (EU) 2020/770 for blackberries, gooseberries, bananas, aubergines/eggplants, lamb's lettuces/corn salads, beans (with pods), globe artichokes, hops, sugar beet roots and products of animal origin. For these commodities, the existing EU MRL could be lowered to the enforcement limit of quantification (LOQ). For kaki/Japanese persimmon and azararoles/mediterranean medlars, the existing EU MRL is set on the basis of Codex MRL in pome fruits. The applicant did not request maintaining a Codex MRL in these commodities, but should risk managers decide otherwise, the Article 12 data gap is considered addressed for kaki/Japanese persimmon while for azaroles/Mediterranean medlars, a risk management decision might be required. No consumer intake concerns were identified.
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- 2024
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30. Modification of the existing maximum residue levels for fluxapyroxad in kaki/Japanese persimmons and cultivated mushrooms
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,fluxapyroxad ,fungicide ,kaki/Japanese persimmons ,MRL ,mushrooms ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted two requests to the competent national authority in Spain and Ireland to modify the existing maximum residue levels (MRLs) for the active substance fluxapyroxad in kaki/Japanese persimmons and in cultivated fungi, respectively. The data submitted in support of the requests were found to be sufficient to derive MRL proposals for kaki/Japanese persimmons and cultivated fungi. Adequate analytical methods for enforcement are available to control the residues of fluxapyroxad on the commodities under consideration at the validated LOQ of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of fluxapyroxad, according to the reported agricultural practices, is unlikely to present a risk to consumer health. The long‐term consumer risk assessment is indicative, pending the submission of the confirmatory data requested under the MRL review.
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- 2024
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31. Non-isothermal non-Newtonian fluids: the stationary case
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Grasselli, Maurizio, Parolini, Nicola, Poiatti, Andrea, and Verani, Marco
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Mathematics - Analysis of PDEs ,Mathematics - Numerical Analysis - Abstract
The stationary Navier-Stokes equations for a non-Newtonian incompressible fluid are coupled with the stationary heat equation and subject to Dirichlet type boundary conditions. The viscosity is supposed to depend on the temperature and the stress depends on the strain through a suit-able power law depending on $p \in (1,2)$ (shear thinning case). For this problem we establish the existence of a weak solution as well as we prove some regularity results both for the Navier-Stokes and the Stokes cases.Then, the latter case with the Carreau power law is approximated through a FEM scheme and some error estimates are obtained. Such estimates are then validated through some two-dimensional numerical experiments.
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- 2022
32. Identification of cavities and inclusions in linear elasticity with a phase-field approach
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Aspri, Andrea, Beretta, Elena, Cavaterra, Cecilia, Rocca, Elisabetta, and Verani, Marco
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Mathematics - Analysis of PDEs - Abstract
In this paper, we deal with the inverse problem of the shape reconstruction of cavities and inclusions embedded in a linear elastic isotropic medium from boundary displacement's measurements. For, we consider a constrained minimization problem involving a boundary quadratic misfit functional with a regularization term that penalizes the perimeter of the cavity or inclusion to be identified. Then using a phase-field approach we derive a robust algorithm for the reconstruction of elastic inclusions and of cavities modeled as inclusions with a very small elasticity tensor.
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- 2022
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33. Level set-fitted polytopal meshes with application to structural topology optimization
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Ferro, Nicola, Micheletti, Stefano, Parolini, Nicola, Perotto, Simona, Verani, Marco, and Antonietti, Paola Francesca
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- 2024
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34. A Virtual Element method for non-Newtonian pseudoplastic Stokes flows
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Antonietti, Paola F., Beirão da Veiga, Lourenço, Botti, Michele, Vacca, Giuseppe, and Verani, Marco
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- 2024
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35. Impact of HIV treat-all and complementary policies on ART linkage in 13 PEPFAR-supported African countries
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Anna Russell, Andre R. Verani, Sherri Pals, Valamar M. Reagon, Lorraine N. Alexander, Eboni T. Galloway, Mayer Magdalene Mange, Pearl Kalimugogo, Ponesai Nyika, Yasmine Moussa Fadil, Appolonia Aoko, Fred Mugyenyi Asiimwe, Akudo Ikpeazu, Dumbani Kayira, Mpho Letebele, Alice Maida, Daniel Magesa, Gram Mutandi, Annie C. Mwila, Dennis Onotu, Kingsly Tse Nkwoh, and Evelyn Wangari
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HIV/AIDS ,Linkage ,Retention ,Treat-all ,Test and start ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background In 2015, the World Health Organization recommended that all people living with HIV begin antiretroviral treatment (ART) regardless of immune status, a policy known as ‘Treat-All to end AIDS’, commonly referred to as Treat-All. Almost all low- and middle-income countries adopted this policy by 2019. This study describes how linkage to treatment of newly diagnosed persons changed between 2015 and 2018 and how complementary policies may have similarly increased linkage for 13 African countries. These countries adopted and implemented Treat-All policies between 2015 and 2018 and were supported by the U.S. Government’s President’s Emergency Plan for AIDS Relief (PEPFAR). The focuses of this research were to understand 1) linkage rates to ART initiation before and after the adoption of Treat-All in each country; 2) how Treat-All implementation differed across these countries; and 3) whether complementary policies (including same-day treatment initiation, task-shifting, reduced ART visits, and reduced ART pickups) implemented around the same time may have increased ART linkage. Methods HIV testing and treatment data were collected by PEPFAR country programs in 13 African countries from 2015 to 2018. These countries were chosen based on the completeness of policy data and availability of program data during the study period. Program data were used to calculate proxy linkage rates. These rates were compared relative to the Treat All adoption period and the adoption of complementary policies. Results The 13 countries experienced an average increase in ART linkage of 29.3% over the entire study period. In examining individual countries, all but two showed increases in linkage to treatment immediately after Treat All adoption. Across all countries, those that had adopted four or more complementary policies showed an average increased linkage of 39.8% compared to 13.9% in countries with fewer than four complementary policies. Conclusions Eleven of 13 country programs examined in this study demonstrated an increase in ART linkage after Treat-All policy adoption. Increases in linkage were associated with complementary policies. When exploring new public health policies, policymakers may consider which complementary policies might also help achieve the desired outcome of the public health policy.
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- 2023
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36. $C^1$-VEM for some variants of the Cahn-Hilliard equation: a numerical exploration
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Antonietti, Paola F., Scacchi, Simone, Vacca, Giuseppe, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
We consider the $C^1$-Virtual Element Method (VEM) for the conforming numerical approximation of some variants of the Cahn-Hilliard equation on polygonal meshes. In particular, we focus on the discretization of the advective Cahn-Hilliard problem and the Cahn-Hilliard inpainting problem. We present the numerical approximation and several numerical results to assess the efficacy of the proposed methodology.
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- 2021
37. On arbitrarily regular conforming virtual element methods for elliptic partial differential equations
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Antonietti, Paola Francesca, Manzini, Gianmarco, Scacchi, Simone, and Verani, Marco
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Mathematics - Numerical Analysis ,65N12, 65N15 - Abstract
The Virtual Element Method (VEM) is a very effective framework to design numerical approximations with high global regularity to the solutions of elliptic partial differential equations. In this paper, we review the construction of such approximations for an elliptic problem of order $p_1$ using conforming, finite dimensional subspaces of $ H^{p_2}(\Omega)$, where $p_1$ and $p_2$ are two integer numbers such that $p_2 \geq p_1 \geq 1$ and $\Omega\in R^2$ is the computational domain. An abstract convergence result is presented in a suitably defined energy norm. The space formulation and major aspects such as the choice and unisolvence of the degrees of freedom are discussed, also providing specific examples corresponding to various practical cases of high global regularity. Finally, the construction of the "enhanced" formulation of the virtual element spaces is also discussed in details with a proof that the dimension of the "regular" and "enhanced" spaces is the same and that the virtual element functions in both spaces can be described by the same choice of the degrees of freedom.
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- 2021
38. Agglomeration-based geometric multigrid schemes for the Virtual Element Method
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Antonietti, Paola Francesca, Berrone, Stefano, Busetto, Martina, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
In this paper we analyse the convergence properties of two-level, W-cycle and V-cycle agglomeration-based geometric multigrid schemes for the numerical solution of the linear system of equations stemming from the lowest order $C^0$-conforming Virtual Element discretization of two-dimensional second-order elliptic partial differential equations. The sequence of agglomerated tessellations are nested, but the corresponding multilevel virtual discrete spaces are generally non-nested thus resulting into non-nested multigrid algorithms. We prove the uniform convergence of the two-level method with respect to the mesh size and the uniform convergence of the W-cycle and the V-cycle multigrid algorithms with respect to the mesh size and the number of levels. Numerical experiments confirm the theoretical findings.
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- 2021
39. Adaptive VEM: Stabilization-Free A Posteriori Error Analysis and Contraction Property
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da Veiga, L. Beirao, Canuto, C., Nochetto, R. H., Vacca, G., and Verani, M.
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Mathematics - Numerical Analysis - Abstract
In the present paper we initiate the challenging task of building a mathematically sound theory for Adaptive Virtual Element Methods (AVEMs). Among the realm of polygonal meshes, we restrict our analysis to triangular meshes with hanging nodes in 2d -- the simplest meshes with a systematic refinement procedure that preserves shape regularity and optimal complexity. A major challenge in the a posteriori error analysis of AVEMs is the presence of the stabilization term, which is of the same order as the residual-type error estimator but prevents the equivalence of the latter with the energy error. Under the assumption that any chain of recursively created hanging nodes has uniformly bounded length, we show that the stabilization term can be made arbitrarily small relative to the error estimator provided the stabilization parameter of the scheme is sufficiently large. This quantitative estimate leads to stabilization-free upper and lower a posteriori bounds for the energy error. This novel and crucial property of VEMs hinges on the largest subspace of continuous piecewise linear functions and the delicate interplay between its coarser scales and the finer ones of the VEM space. An important consequence for piecewise constant data is a contraction property between consecutive loops of AVEMs, which we also prove. Our results apply to $H^1$-conforming (lowest order) VEMs of any kind, including the classical and enhanced VEMs.
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- 2021
40. Iterative solution to the biharmonic equation in mixed form discretized by the Hybrid High-Order method
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Antonietti, P.F., Matalon, P., and Verani, M.
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- 2024
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41. Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
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Lewis, Nathaniel M, Naioti, Eric A, Self, Wesley H, Ginde, Adit A, Douin, David J, Talbot, H Keipp, Casey, Jonathan D, Mohr, Nicholas M, Zepeski, Anne, Gaglani, Manjusha, Ghamande, Shekhar A, McNeal, Tresa A, Shapiro, Nathan I, Gibbs, Kevin W, Files, D Clark, Hager, David N, Shehu, Arber, Prekker, Matthew E, Erickson, Heidi L, Gong, Michelle N, Mohamed, Amira, Henning, Daniel J, Steingrub, Jay S, Peltan, Ithan D, Brown, Samuel M, Martin, Emily T, Hubel, Kinsley, Hough, Catherine L, Busse, Laurence W, Lohuis, Caitlin C ten, Duggal, Abhijit, Wilson, Jennifer G, Gordon, Alexandra J, Qadir, Nida, Chang, Steven Y, Mallow, Christopher, Rivas, Carolina, Babcock, Hilary M, Kwon, Jennie H, Exline, Matthew C, Halasa, Natasha, Chappell, James D, Lauring, Adam S, Grijalva, Carlos G, Rice, Todd W, Rhoads, Jillian P, Stubblefield, William B, Baughman, Adrienne, Womack, Kelsey N, Lindsell, Christopher J, Hart, Kimberly W, Zhu, Yuwei, Schrag, Stephanie J, Kobayashi, Miwako, Verani, Jennifer R, Patel, Manish M, Tenforde, Mark W, Collaborators, IVY Network, McNeal, Tresa, Ghamande, Shekhar, Calhoun, Nicole, Murthy, Kempapura, Herrick, Judy, McKillop, Amanda, Hoffman, Eric, Zayed, Martha, Smith, Michael, Settele, Natalie, Ettlinger, Jason, Priest, Elisa, Thomas, Jennifer, Arroliga, Alejandro, Beeram, Madhava, Kindle, Ryan, Kozikowski, Lori-Ann, De Souza, Lesley, Ouellette, Scott, Thornton-Thompson, Sherell, Tyler, Patrick, Mehkri, Omar, Mitchell, Meg, Brennan, Connery, Ashok, Kiran, Poynter, Bryan, Stanley, Nicholas, Hendrickson, Audrey, Caspers, Sean, Scharber, Tyler, Jorgensen, Jeffrey, Bowers, Robert, King, Jennifer, Aston, Valerie, Armbruster, Brent, Rothman, Richard E, Nair, Rahul, Chen, Jen-Ting, Karow, Sarah, Robart, Emily, Maldonado, Paulo Nunes, and Khan, Maryiam
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Immunization ,Aging ,Vaccine Related ,Good Health and Well Being ,Adult ,COVID-19 ,COVID-19 Vaccines ,Chronic Disease ,Hospitalization ,Humans ,Vaccines ,Synthetic ,mRNA Vaccines ,chronic medical conditions ,preexisting conditions ,vaccine effectiveness ,IVY Network Collaborators ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.
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- 2022
42. Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States
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Tenforde, Mark W, Patel, Manish M, Ginde, Adit A, Douin, David J, Talbot, H Keipp, Casey, Jonathan D, Mohr, Nicholas M, Zepeski, Anne, Gaglani, Manjusha, McNeal, Tresa, Ghamande, Shekhar, Shapiro, Nathan I, Gibbs, Kevin W, Files, D Clark, Hager, David N, Shehu, Arber, Prekker, Matthew E, Erickson, Heidi L, Exline, Matthew C, Gong, Michelle N, Mohamed, Amira, Henning, Daniel J, Steingrub, Jay S, Peltan, Ithan D, Brown, Samuel M, Martin, Emily T, Monto, Arnold S, Khan, Akram, Hough, Catherine L, Busse, Laurence W, Ten Lohuis, Caitlin C, Duggal, Abhijit, Wilson, Jennifer G, Gordon, Alexandra June, Qadir, Nida, Chang, Steven Y, Mallow, Christopher, Gershengorn, Hayley B, Babcock, Hilary M, Kwon, Jennie H, Halasa, Natasha, Chappell, James D, Lauring, Adam S, Grijalva, Carlos G, Rice, Todd W, Jones, Ian D, Stubblefield, William B, Baughman, Adrienne, Womack, Kelsey N, Lindsell, Christopher J, Hart, Kimberly W, Zhu, Yuwei, Olson, Samantha M, Stephenson, Meagan, Schrag, Stephanie J, Kobayashi, Miwako, Verani, Jennifer R, and Self, Wesley H
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Pneumonia & Influenza ,Immunization ,Biodefense ,Vaccine Related ,Clinical Research ,Lung ,Infectious Diseases ,Emerging Infectious Diseases ,Pneumonia ,Prevention ,Prevention of disease and conditions ,and promotion of well-being ,3.4 Vaccines ,Infection ,Good Health and Well Being ,Adult ,COVID-19 ,COVID-19 Vaccines ,Hospitalization ,Humans ,Middle Aged ,RNA ,SARS-CoV-2 ,United States ,mRNA Vaccines ,vaccine effectiveness ,mRNA vaccines ,hospitalized ,immunocompromised ,Influenza and Other Viruses in the Acutely Ill (IVY) Network ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
BackgroundAs severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination coverage increases in the United States, there is a need to understand the real-world effectiveness against severe coronavirus disease 2019 (COVID-19) and among people at increased risk for poor outcomes.MethodsIn a multicenter case-control analysis of US adults hospitalized March 11-May 5, 2021, we evaluated vaccine effectiveness to prevent COVID-19 hospitalizations by comparing odds of prior vaccination with a messenger RNA (mRNA) vaccine (Pfizer-BioNTech or Moderna) between cases hospitalized with COVID-19 and hospital-based controls who tested negative for SARS-CoV-2.ResultsAmong 1212 participants, including 593 cases and 619 controls, median age was 58 years, 22.8% were Black, 13.9% were Hispanic, and 21.0% had immunosuppression. SARS-CoV-2 lineage B0.1.1.7 (Alpha) was the most common variant (67.9% of viruses with lineage determined). Full vaccination (receipt of 2 vaccine doses ≥14 days before illness onset) had been received by 8.2% of cases and 36.4% of controls. Overall vaccine effectiveness was 87.1% (95% confidence interval [CI], 80.7-91.3). Vaccine effectiveness was similar for Pfizer-BioNTech and Moderna vaccines, and highest in adults aged 18-49 years (97.4%; 95% CI, 79.3-9.7). Among 45 patients with vaccine-breakthrough COVID hospitalizations, 44 (97.8%) were ≥50 years old and 20 (44.4%) had immunosuppression. Vaccine effectiveness was lower among patients with immunosuppression (62.9%; 95% CI,20.8-82.6) than without immunosuppression (91.3%; 95% CI, 85.6-94.8).ConclusionDuring March-May 2021, SARS-CoV-2 mRNA vaccines were highly effective for preventing COVID-19 hospitalizations among US adults. SARS-CoV-2 vaccination was beneficial for patients with immunosuppression, but effectiveness was lower in the immunosuppressed population.
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- 2022
43. A posteriori error analysis for a coupled Stokes-poroelastic system with multiple compartments.
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Ivan Fumagalli, Nicola Parolini, and Marco Verani
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- 2024
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44. A Virtual Element method for non-Newtonian fluid flows.
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Paola F. Antonietti, L. Beirão da Veiga, Michele Botti, Giuseppe Vacca, and Marco Verani
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- 2024
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45. Learning epidemic trajectories through Kernel Operator Learning: from modelling to optimal control.
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Giovanni Ziarelli, Nicola Parolini, and Marco Verani
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- 2024
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46. Structure-preserving neural networks in data-driven rheological models.
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Nicola Parolini, Andrea Poiatti, Julian Vene', and Marco Verani
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- 2024
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47. Effectiveness of 13-valent pneumococcal conjugate vaccine for prevention of invasive pneumococcal disease among children in the United States between 2010 and 2019: An indirect cohort study
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Andrejko, Kristin L., Gierke, Ryan, Rowlands, Jemma V., Rosen, Jennifer B., Thomas, Ann, Landis, Zachary Q., Rosales, Maria, Petit, Sue, Schaffner, William, Holtzman, Corinne, Barnes, Meghan, Farley, Monica M., Harrison, Lee H., McGee, Lesley, Chochua, Sopio, Verani, Jennifer R., Cohen, Adam L., Pilishvili, Tamara, and Kobayashi, Miwako
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- 2024
- Full Text
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48. Impact of HIV treat-all and complementary policies on ART linkage in 13 PEPFAR-supported African countries
- Author
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Russell, Anna, Verani, Andre R., Pals, Sherri, Reagon, Valamar M., Alexander, Lorraine N., Galloway, Eboni T., Mange, Mayer Magdalene, Kalimugogo, Pearl, Nyika, Ponesai, Fadil, Yasmine Moussa, Aoko, Appolonia, Asiimwe, Fred Mugyenyi, Ikpeazu, Akudo, Kayira, Dumbani, Letebele, Mpho, Maida, Alice, Magesa, Daniel, Mutandi, Gram, Mwila, Annie C., Onotu, Dennis, Nkwoh, Kingsly Tse, and Wangari, Evelyn
- Published
- 2023
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49. Evaluation of confirmatory data following the Article 12 MRL review for quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop and modification of the existing maximum residue levels for quizalofop‐P‐tefuryl
- Author
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
confirmatory data ,MRL review ,pesticide ,propaquizafop ,quizalofop‐P‐ethyl ,quizalofop‐P‐tefuryl ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Arysta Life Science Great Britain Limited submitted a request to the competent national authority in Croatia to evaluate the confirmatory data that were identified for quizalofop‐P‐tefuryl in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. Since Article 12 data gaps were also set for the two other quizalofop‐P variants sharing the same residue definitions for risk assessment and monitoring, EFSA included in the present assessment all quizalofop‐P variants: quizalofop‐P‐ethyl, quizalofop‐P‐tefuryl and propaquizafop. Moreover, in the application submitted to Croatia, the applicant also included a request to modify the existing MRLs for quizalofop‐P‐tefuryl in grapes, sunflower seeds and soyabeans in accordance with Article 6 of Regulation (EC) No 396/2005. To address the data gaps, new data on hydrolysis efficiency of quizalofop‐P‐tefuryl, quizalofop acid, quizalofop‐pentanoic acid and quizalofop‐P‐glycerate in different matrices of animal origin in accordance with the guidance document SANTE/2020/12830 Rev.1 were submitted, along with a validated analytical method for animal commodities. EFSA concluded that the data gap on validation of the efficiency of the extraction and hydrolysis included in the enforcement method of residues in livestock animal commodities was only fully addressed for muscle, poultry liver and eggs. Regarding plant commodities, the remaining data gaps were not addressed. EFSA also considered data gaps for quizalofop‐p‐ethyl in caraway as sufficiently addressed in the context of a previous MRL application. In general, the new information provided required a revision of the existing MRLs for several commodities of plant and animal origin. Further risk management considerations are required. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of quizalofop‐P‐tefuryl according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2024
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50. Updated reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Andrea Mioč, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
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benzimidazole substances ,carbendazim ,consumer risk assessment ,MRL ,Regulation (EC) No 396/2005 ,thiophanate‐methyl ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received from the European Commission in 2020 a mandate to provide its reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl. Specifically, EFSA was asked to assess whether thiophanate‐methyl or carbendazim has clastogenic potential and, in case clastogenic potential can be excluded, to derive toxicological reference values necessary for consumer risk assessment and assessment of maximum residue levels (MRLs). Although these active substances are no longer authorised within the European Union, MRLs were established by the Codex Alimentarius Commission (codex maximum residue limits; CXLs), and import tolerances are in place. Based on the assessment of the available data, toxicological reference values and MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was found to be missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment was considered indicative only and all MRL proposals derived by EFSA still require further consideration by risk managers. In October 2022, to ensure that MRLs derived by EFSA in its assessment of 2021 are safe for consumers also in view of endocrine‐disrupting properties, EFSA was requested to carry out a follow‐up assessment taking into account the scientific criteria for identifying endocrine disruptors (ED). Based on the outcome of the assessment, the experts agreed that the reference values are also covering the concern related to the identified hazards indicative of endocrine disruption for thiophanate‐methyl. No further considerations on the impact of the ED assessment on the current reference values were needed for carbendazim since the ED criteria are not met for this substance. Therefore, the risk assessment and the MRL recommendations derived in 2021 are confirmed.
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- 2024
- Full Text
- View/download PDF
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