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9. Addendum to ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2—Evidence Base and Standardized Methods of Imaging

Author

Dorbala, SHARMILA, ANDO, YUKIO, BOKHARI, SABAHAT, DISPENZIERI, ANGELA, FALK, RODNEY H., FERRARI, VICTOR A., FONTANA, MARIANNA, GHEYSENS, OLIVIER, GILLMORE, JULIAN D., GLAUDEMANS, ANDOR W.J.M., HANNA, MAZEN A., HAZENBERG, BOUKE P.C., KRISTEN, ARNT V., KWONG, RAYMOND Y., MAURER, MATHEW S., MERLINI, GIAMPAOLO, MILLER, EDWARD J., MOON, JAMES C., MURTHY, VENKATESH L., QUARTA, C. CRISTINA, RAPEZZI, CLAUDIO, RUBERG, FREDERICK L., SHAH, SANJIV J., SLART, RIEMER H.J.A., VERBERNE, HEIN J., and BOURQUE, JAMIESON M.

Published
2022
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10. First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin.

Author

Oostveen, Reindert F., Zheng, Kang H., Kaiser, Yannick, Nurmohamed, Nick S., Kroon, Jeffrey, de Wit, Tim C., Poel, Edwin, Aerts, Joel, Rouzet, Francois, Stroes, Erik S. G., Letourneur, Didier, Verberne, Hein J., Chauvierre, Cédric, and Ståhle, Mia R.

Subjects
VENOUS thrombosis, COMPUTED tomography, CURRENT good manufacturing practices, ABSORBED dose, INTRAVENOUS injections
Abstract

Background: Activation of endothelial cells and platelets in atherothrombosis is characterized by upregulation of P-selectin. As a consequence, P-selectin represents a potential target for molecular imaging to identify thrombosis at an early stage. Fucoidan is a polysaccharide ligand extracted from brown algae with nanomolar affinity for P-selectin. This first-in-human study evaluated in healthy volunteers the safety, whole-body biodistribution, and dosimetry of 99mTc-fucoidan (Good Manufacturing Practices grade). We also investigated whether we could observe binding of 99mTc-fucoidan to human thrombi ex vivo and in vivo. In ten healthy volunteers, conjugate whole-body scans were performed up to 24 h following intravenous injection of 99mTc-fucoidan (370 MBq). Moreover, 99mTc-fucoidan uptake in ex vivo human thrombi (n = 11) was measured by gamma counting. Additionally, three patients with a newly diagnosed deep vein thrombosis (DVT) were subjected to 99mTc-fucoidan SPECT/CT imaging. Results: 99mTc-fucoidan was well tolerated in all participants without any drug-related adverse events. The total-body absorbed dose in males was comparable to females (0.012 ± 0.004 vs. 0.011 ± 0.005 mSv/MBq; p = 0.97). Gamma counting experiments demonstrated binding of tracer to ex vivo human thrombi that was 16% lower after blocking with a natural P-selectin ligand, Sialyl Lewis X. 99mTc-fucoidan demonstrated specific uptake at the thrombus site in one out of three scanned patients with DVT. Conclusions: 99mTc-Fucoidan has a favorable biodistribution and safety profile. 99mTc-fucoidan exhibited specific binding to human thrombi in both in vivo and ex vivo settings. Nonetheless, the in vivo results do not support further clinical investigation of 99mTc-fucoidan as an imaging modality for DVT. Other clinical implementations of a technetium− 99m-labeled P-selectin tracer should be considered. Trial registration: Clinicaltrials,NCT03422055.Registered 01/15/2018. URL: https://clinicaltrials.gov/study/NCT03422055Landelijk Trial Register, NL7739. Registered 4/2/2019. https://onderzoekmetmensen.nl/en/trial/26785 [ABSTRACT FROM AUTHOR]

Published
2024
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17. Addendum to ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2—evidence base and standardized methods of imaging

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W.J.M., Hanna, Mazen A., Hazenberg, Bouke P.C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C. Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H.J.A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2021
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19. Correction to: ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2—Diagnostic criteria and appropriate utilization

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W. J. M., Hanna, Mazen A., Hazenberg, Bouke P. C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C. Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H. J. A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2021
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20. Position paper of the EACVI and EANM on artificial intelligence applications in multimodality cardiovascular imaging using SPECT/CT, PET/CT, and cardiac CT

Author

Slart, Riemer H. J. A., Williams, Michelle C., Juarez-Orozco, Luis Eduardo, Rischpler, Christoph, Dweck, Marc R., Glaudemans, Andor W. J. M., Gimelli, Alessia, Georgoulias, Panagiotis, Gheysens, Olivier, Gaemperli, Oliver, Habib, Gilbert, Hustinx, Roland, Cosyns, Bernard, Verberne, Hein J., Hyafil, Fabien, Erba, Paola A., Lubberink, Mark, Slomka, Piotr, Išgum, Ivana, Visvikis, Dimitris, Kolossváry, Márton, and Saraste, Antti

Published
2021
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25. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2—Diagnostic criteria and appropriate utilization

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W. J. M., Hanna, Mazen A., Hazenberg, Bouke P. C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C. Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H. J. A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2020
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30. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2—Evidence Base and Standardized Methods of Imaging

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W.J.M., Hanna, Mazen A., Hazenberg, Bouke P.C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C. Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H.J.A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2019
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31. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 2 of 2—Diagnostic Criteria and Appropriate Utilization

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W.J.M., Hanna, Mazen A., Hazenberg, Bouke P.C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C.Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H.J.A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2019
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36. Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship between 123I-meta-iodobenzylguanidine activity and event rates.

Author

Nakajima, Kenichi, Nakata, Tomoaki, Doi, Takahiro, Verschure, Derk O., Frantellizzi, Viviana, De Feo, Maria Silvia, Tada, Hayato, and Verberne, Hein J.

Subjects
ARRHYTHMIA, CARDIAC pacing, CARDIAC arrest, VENTRICULAR tachycardia, HEART failure patients, CARDIAC resuscitation
Abstract

Background: 123I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between 123I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. This study aimed to determine this relationship in Japanese and European cohorts. Results: We calculated heart-to-mediastinum (H/M) count ratios and washout rates (WRs) of 827 patients using planar 123I-mIBG imaging. We defined ArEs as sudden cardiac death, arrhythmic death, and potentially lethal events such as sustained ventricular tachycardia, cardiac arrest with resuscitation, and appropriate implantable cardioverter defibrillator (ICD) discharge, either from a single ICD or as part of a cardiac resynchronization therapy device (CRTD). We analyzed the incidence of ArE with respect to H/M ratios, WRs and New York Heart Association (NYHA) functional classes among Japanese (J; n = 581) and European (E; n = 246) cohorts. We also simulated ArE rates versus H/M ratios under specific conditions using a machine-learning model incorporating 13 clinical variables. Consecutive patients with CHF were selected in group J, whereas group E comprised candidates for cardiac electronic devices. Groups J and E mostly comprised patients with NYHA functional classes I/II (95%) and II/III (91%), respectively, and 21% and 72% were respectively implanted with ICD/CRTD devices. The ArE rate increased with lower H/M ratios in group J, but the relationship was bell-shaped, with a high ArE rate within the intermediate H/M range, in group E. This bell-shaped curve was also evident in patients with NYHA classes II/III in the combined J and E groups, particularly in those with a high (> 15%) mIBG WR and with ischemic, but not in those with non-ischemic etiologies. Machine learning-based prediction of ArE risk aligned with these findings, indicating a bell-shaped curve in NYHA class II/III but not in class I. Conclusions: The relationship between cardiac 123I-mIBG activity and lethal arrhythmic events is influenced by the background of patients. The bell-shaped relationship in NYHA classes II/III, high WR, and ischemic etiology likely aids in identifying patients at high risk for ArEs. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Correction to: ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2—evidence base and standardized methods of imaging

Author

Dorbala, Sharmila, Ando, Yukio, Bokhari, Sabahat, Dispenzieri, Angela, Falk, Rodney H., Ferrari, Victor A., Fontana, Marianna, Gheysens, Olivier, Gillmore, Julian D., Glaudemans, Andor W. J. M., Hanna, Mazen A., Hazenberg, Bouke P. C., Kristen, Arnt V., Kwong, Raymond Y., Maurer, Mathew S., Merlini, Giampaolo, Miller, Edward J., Moon, James C., Murthy, Venkatesh L., Quarta, C. Cristina, Rapezzi, Claudio, Ruberg, Frederick L., Shah, Sanjiv J., Slart, Riemer H. J. A., Verberne, Hein J., and Bourque, Jamieson M.

Published
2021
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48. Benefits of Using Stereotactic Body Radiotherapy in Patients With Metachronous Oligometastases of Hormone-Sensitive Prostate Cancer Detected by [18F]fluoromethylcholine PET/CT

Author

Bouman-Wammes, Esther W., van Dodewaard-De Jong, Joyce M., Dahele, Max, Cysouw, Matthijs C.F., Hoekstra, Otto S., van Moorselaar, R. Jeroen A., Piet, Maartje A.H., Verberne, Hein J., Bins, Adriaan D., Verheul, Henk M.W., Slotman, Ben J., Oprea-Lager, Daniela E., and Van den Eertwegh, Alfons J.M.

Published
2017
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