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807 results on '"Vercruysse, Jozef"'

6. The assessment of single nucleotide polymorphisms in the ß-tubulin genes in human soil-transmitted helminths exposed to different pressure with benzimidazole drugs

Author

Levecke, Bruno, primary, Rashwan, Nour, additional, Cools, Piet, additional, Albonico, Marco, additional, Ame, Shaali M, additional, Ayana, Mio, additional, Dana, Daniel, additional, Keiser, Jennifer, additional, Montresor, Antonio, additional, Mekonnen, Zeleke, additional, Roose, Sara, additional, Sayasone, Somphou, additional, Vercruysse, Jozef, additional, Verweij, Jaco J, additional, Vlaminck, Johnny, additional, and Prichard, Roger, additional

Published
2024
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7. A Double-Blind Randomized Controlled Trial of Maternal Postpartum Deworming to Improve Infant Weight Gain in the Peruvian Amazon.

Author

Mofid, Layla S, Casapía, Martín, Aguilar, Eder, Silva, Hermánn, Montresor, Antonio, Rahme, Elham, Fraser, William D, Marquis, Grace S, Vercruysse, Jozef, Allen, Lindsay H, Blouin, Brittany, Razuri, Hugo, Pezo, Lidsky, and Gyorkos, Theresa W

Subjects
Humans, Helminthiasis, Infant, Newborn, Diseases, Weight Gain, Albendazole, Anthelmintics, Follow-Up Studies, Double-Blind Method, Mothers, Postpartum Period, Adult, Infant, Infant, Newborn, Peru, Female, Male, Young Adult, Newborn, Diseases, Biological Sciences, Medical and Health Sciences, Tropical Medicine
Abstract

BackgroundNutritional interventions targeting the critical growth and development period before two years of age can have the greatest impact on health trajectories over the life course. Compelling evidence has demonstrated that interventions investing in maternal health in the first 1000 days of life are beneficial for both mothers and their children. One such potential intervention is deworming integrated into maternal postpartum care in areas where soil-transmitted helminth (STH) infections are endemic.Methodology/principal findingsFrom February to August 2014, 1010 mother-infant pairs were recruited into a trial aimed at assessing the effectiveness of maternal postpartum deworming on infant and maternal health outcomes. Following delivery, mothers were randomly assigned to receive either single-dose 400 mg albendazole or placebo. Participants were followed-up at 1 and 6 months postpartum. There was no statistically significant difference in mean weight gain between infants in the experimental and control groups (mean difference: -0.02; 95% CI: -0.1, 0.08) at 6 months of age. Further, deworming had no effect on measured infant morbidity indicators. However, ad hoc analyses restricted to mothers who tested positive for STHs at baseline suggest that infants of mothers in the experimental group had greater mean length gain in cm (mean difference: 0.8; 95% CI: 0.1, 1.4) and length-for-age z-score (mean difference: 0.5; 95% CI: 0.2, 0.8) at 6 months of age.Conclusions/significanceIn a study population composed of both STH-infected and uninfected mothers, maternal postpartum deworming was insufficient to impact infant growth and morbidity indicators up to 6 months postpartum. Among STH-infected mothers, however, important improvements in infant length gain and length-for-age were observed. The benefits of maternal postpartum deworming should be further investigated in study populations having higher overall prevalences and intensities of STH infections and, in particular, where whipworm and hookworm infections are of public health concern.Trial registrationClinicalTrials.gov (NCT01748929).

Published
2017

8. Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period

Author

Mofid, Layla S, Casapía, Martín, Montresor, Antonio, Rahme, Elham, Fraser, William D, Marquis, Grace S, Vercruysse, Jozef, Allen, Lindsay H, and Gyorkos, Theresa W

Subjects
Pediatric, Clinical Trials and Supportive Activities, Prevention, Clinical Research, Infant Mortality, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Reproductive health and childbirth, Good Health and Well Being, Adult, Albendazole, Anthelmintics, Breast Feeding, Cost-Benefit Analysis, Double-Blind Method, Female, Helminthiasis, Humans, Infant, Infant Nutrition Disorders, Infant Nutritional Physiological Phenomena, Infant, Newborn, Lactation, Male, Maternal Nutritional Physiological Phenomena, Mothers, Peru, Postpartum Period, Pregnancy, Soil, Treatment Outcome, PARASITOLOGY, albendazole, helminthiasis, intervention study, postpartum, randomised controlled trials, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionSoil-transmitted helminth infections are endemic in 114 countries worldwide, and cause the highest burden of disease among all neglected tropical diseases. The WHO includes women of reproductive age as a high-risk group for infection. The primary consequence of infection in this population is anaemia. During lactation, anaemia may contribute to reduced quality and quantity of milk, decreasing the duration of exclusive breastfeeding and lowering the age at weaning. To date, no study has investigated the effects of maternal postpartum deworming on infant or maternal health outcomes.Methods and analysisA single-centre, parallel, double-blind, randomised, placebo-controlled trial will be carried out in Iquitos, Peru, to assess the effectiveness of integrating single-dose 400 mg albendazole into routine maternal postpartum care. A total of 1010 mother-infant pairs will be randomised to either the intervention or control arm, following inhospital delivery and prior to discharge. Participants will be visited in their homes at 1, 6, 12 and 24 months following delivery for outcome ascertainment. The primary outcome is infant mean weight gain between birth and 6 months of age. Secondary outcomes include other infant growth indicators and morbidity, maternal soil-transmitted helminth infection and intensity, anaemia, fatigue, and breastfeeding practices. All statistical analyses will be performed on an intention-to-treat basis.Ethics and disseminationResearch ethics board approval has been obtained from the McGill University Health Centre (Canada), the Asociación Civil Impacta Salud y Educación (Peru) and the Instituto Nacional de Salud (Peru). A data safety and monitoring committee is in place to oversee study progression and evaluate adverse events. The results of the analyses will be published in peer-reviewed journals, and presented at national and international conferences.Trial registration numberClinicaltrials.gov: NCT01748929.

Published
2015

9. 100 Questions in Livestock Helminthology Research

Author

Morgan, Eric R., Aziz, Nor-Azlina A., Blanchard, Alexandra, Charlier, Johannes, Charvet, Claude, Claerebout, Edwin, Geldhof, Peter, Greer, Andrew W., Hertzberg, Hubertus, Hodgkinson, Jane, Höglund, Johan, Hoste, Hervé, Kaplan, Ray M., Martínez-Valladares, María, Mitchell, Siân, Ploeger, Harm W., Rinaldi, Laura, von Samson-Himmelstjerna, Georg, Sotiraki, Smaragda, Schnyder, Manuela, Skuce, Philip, Bartley, David, Kenyon, Fiona, Thamsborg, Stig M., Vineer, Hannah Rose, de Waal, Theo, Williams, Andrew R., van Wyk, Jan A., and Vercruysse, Jozef

Published
2019
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14. Confounding factors affecting faecal egg count reduction as a measure of anthelmintic efficacy

Author

Morgan Eric R., Lanusse Carlos, Rinaldi Laura, Charlier Johannes, and Vercruysse Jozef

Subjects
helminths, anthelmintic resistance, faecal egg count reduction test, drug pharmacology related therapeutic failures, pharmacokinetics, epidemiology, effectiveness, Infectious and parasitic diseases, RC109-216
Abstract

Increasing anthelmintic resistance (AR) in livestock has stimulated growing efforts to monitor anthelmintic effectiveness (AE) on livestock farms. On-farm assessment of AE relies on measuring the reduction in faecal egg count (FEC) following treatment; and if conducted rigorously, qualifies as a formal FEC reduction test (FECRT) for AR. Substantial research effort has been devoted to designing robust protocols for the FECRT and its statistical interpretation; however, a wide range of factors other than AR can affect FEC reduction on farms. These are not always possible to control, and can affect the outcome and repeatability of AE measurements and confound the on-farm classification of AR using FECRT. This review considers confounders of FEC reduction, focusing on gastrointestinal nematodes of ruminants, including host and parasite physiology and demography; pharmacokinetic variation between drugs, parasites and hosts; and technical performance. Drug formulation and delivery, host condition and diet, and seasonal variation in parasite species composition, can all affect AE and hence observed FEC reduction. Causes of variation in FEC reduction should be attenuated, but this is not always possible. Regular monitoring of AE can indicate a need to improve anthelmintic administration practices, and detect AR early in its progression. Careful interpretation of FEC reduction, however, taking into account possible confounders, is essential before attributing reduced FEC reduction to AR. Understanding of confounders of FEC reduction will complement advances in FECRT design and interpretation to provide measures of anthelmintic efficacy that are both rigorous and accessible.

Published
2022
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17. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E., primary, Vlaminck, Johnny, additional, Cools, Piet, additional, Denwood, Matthew, additional, Albonico, Marco, additional, Ame, Shaali M., additional, Ayana, Mio, additional, Dana, Daniel, additional, Cringoli, Giuseppe, additional, de Vlas, Sake J., additional, Fenwick, Alan, additional, French, Michael, additional, Kazienga, Adama, additional, Keiser, Jennifer, additional, Knopp, Stefanie, additional, Leta, Gemechu, additional, Matoso, Leonardo F., additional, Maurelli, Maria P., additional, Montresor, Antonio, additional, Mirams, Greg, additional, Mekonnen, Zeleke, additional, Corrêa-Oliveira, Rodrigo, additional, Pinto, Simone A., additional, Rinaldi, Laura, additional, Sayasone, Somphou, additional, Steinmann, Peter, additional, Thomas, Eurion, additional, Vercruysse, Jozef, additional, and Levecke, Bruno, additional

Published
2023
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23. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E., Vlaminck, Johnny, Cools, Piet, Denwood, Matthew, Albonico, Marco, Ame, Shaali M., Ayana, Mio, Dana, Daniel, Cringoli, Giuseppe, de Vlas, Sake J., Fenwick, Alan, French, Michael, Kazienga, Adama, Keiser, Jennifer, Knopp, Stefanie, Leta, Gemechu, Matoso, Leonardo F., Maurelli, Maria P., Montresor, Antonio, Mirams, Greg, Mekonnen, Zeleke, Corrêa-Oliveira, Rodrigo, Pinto, Simone A., Rinaldi, Laura, Sayasone, Somphou, Steinmann, Peter, Thomas, Eurion, Vercruysse, Jozef, Levecke, Bruno, Coffeng, Luc E., Vlaminck, Johnny, Cools, Piet, Denwood, Matthew, Albonico, Marco, Ame, Shaali M., Ayana, Mio, Dana, Daniel, Cringoli, Giuseppe, de Vlas, Sake J., Fenwick, Alan, French, Michael, Kazienga, Adama, Keiser, Jennifer, Knopp, Stefanie, Leta, Gemechu, Matoso, Leonardo F., Maurelli, Maria P., Montresor, Antonio, Mirams, Greg, Mekonnen, Zeleke, Corrêa-Oliveira, Rodrigo, Pinto, Simone A., Rinaldi, Laura, Sayasone, Somphou, Steinmann, Peter, Thomas, Eurion, Vercruysse, Jozef, and Levecke, Bruno

Abstract

Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendations, using a case study of therapeutic drug efficacy monitoring based on the examination of helminth eggs in stool. Methods We performed an in-depth analysis of the operational costs to process one stool sample for three diagnostic methods (Kato-Katz, Mini-FLOTAC and FECPAKG2). Next, we performed simulations to determine the probability of detecting a truly reduced therapeutic efficacy for different scenarios of STH species (Ascaris lumbricoides, Trichuris trichiura and hook-worms), pre-treatment infection levels, survey design (screen and select (SS); screen, select and retest (SSR) and no selection (NS)) and number of subjects enrolled (100– 5,000). Finally, we integrated the outcome of the cost assessment into the simulation study to estimate the total survey costs and determined the most cost-efficient survey design. Principal findings Kato-Katz allowed for both the highest sample throughput and the lowest cost per test, while FECPAKG2 required both the most laboratory time and was the most expensive. Counting of eggs accounted for 23% (FECPAKG2) or ≥80% (Kato-Katz and Mini-FLOTAC) of the total time-to-result. NS survey designs in combination with Kato-Katz were the most cost-efficient to assess therapeutic drug efficacy in all scenarios of STH species and endemicity. Conclusions/significance We confirm that Kato-Katz is the fecal egg counting method of choice for monitoring therapeutic drug efficacy, but that the survey design currently recommended by WHO (SS) should be updated. Our generic framework, which captures laboratory time and material costs, can be used to further support cost-efficient choices for other important surveys informing STH control programs. In addition, it can be used t

Published
2023

24. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline for diagnosing anthelmintic resistance using the faecal egg count reduction test in ruminants, horses and swine

Author

Kaplan, Ray M, Denwood, Matthew J, Nielsen, Martin K, Thamsborg, Stig M, Torgerson, Paul R; https://orcid.org/0000-0003-4277-9983, Gilleard, John S, Dobson, Robert J, Vercruysse, Jozef, Levecke, Bruno, Kaplan, Ray M, Denwood, Matthew J, Nielsen, Martin K, Thamsborg, Stig M, Torgerson, Paul R; https://orcid.org/0000-0003-4277-9983, Gilleard, John S, Dobson, Robert J, Vercruysse, Jozef, and Levecke, Bruno

Abstract

The faecal egg count reduction test (FECRT) remains the method of choice for establishing the efficacy of anthelmintic compounds in the field, including the diagnosis of anthelmintic resistance. We present a guideline for improving the standardization and performance of the FECRT that has four sections. In the first section, we address the major issues relevant to experimental design, choice of faecal egg count (FEC) method, statistical analysis, and interpretation of the FECRT results. In the second section, we make a series of general recommendations that are applicable across all animals addressed in this guideline. In the third section, we provide separate guidance details for cattle, small ruminants (sheep and goats), horses and pigs to address the issues that are specific to the different animal types. Finally, we provide overviews of the specific details required to conduct an FECRT for each of the different host species. To address the issues of statistical power vs. practicality, we also provide two separate options for each animal species; (i) a version designed to detect small changes in efficacy that is intended for use in scientific studies, and (ii) a less resource-intensive version intended for routine use by veterinarians and livestock owners to detect larger changes in efficacy. Compared to the previous FECRT recommendations, four important differences are noted. First, it is now generally recommended to perform the FECRT based on pre- and post-treatment FEC of the same animals (paired study design), rather than on post-treatment FEC of both treated and untreated (control) animals (unpaired study design). Second, instead of requiring a minimum mean FEC (expressed in eggs per gram (EPG)) of the group to be tested, the new requirement is for a minimum total number of eggs to be counted under the microscope (cumulative number of eggs counted before the application of a conversion factor). Third, we provide flexibility in the required size of the treatm

Published
2023

29. A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E, primary, Vlaminck, Johnny, additional, Cools, Piet, additional, Denwood, Matthew, additional, Albonico, Marco, additional, Ame, Shaali M, additional, Ayana, Mio, additional, Dana, Daniel, additional, Cringoli, Giuseppe, additional, de Vlas, Sake J, additional, Fenwick, Alan, additional, French, Michael, additional, Kazienga, Adama, additional, Keiser, Jennifer, additional, Knopp, Stefanie, additional, Leta, Gemechu, additional, Matoso, Leonardo F., additional, Maurelli, Maria P., additional, Montresor, Antonio, additional, Mirams, Greg, additional, Mekonnen, Zeleke, additional, Corrêa-Oliveira, Rodrigo, additional, Pinto, Simone A., additional, Rinaldi, Laura, additional, Sayasone, Somphou, additional, Steinmann, Peter, additional, Thomas, Eurion, additional, Vercruysse, Jozef, additional, and Levecke, Bruno, additional

Published
2023
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