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471 results on '"Verde, Federico"'

2. How to detect affect recognition alterations in amyotrophic lateral sclerosis

Author

Castelnovo, Veronica, Canu, Elisa, Aiello, Edoardo Nicolò, Curti, Beatrice, Sibilla, Elisa, Torre, Silvia, Freri, Fabiola, Tripodi, Chiara, Lumaca, Laura, Spinelli, Edoardo Gioele, Schito, Paride, Russo, Tommaso, Falzone, Yuri, Verde, Federico, Silani, Vincenzo, Ticozzi, Nicola, Sturm, Virginia E., Rankin, Katherine P., Gorno-Tempini, Maria Luisa, Poletti, Barbara, Filippi, Massimo, and Agosta, Federica

Published
2024
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5. Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients

Author

Poletti, Barbara, Aiello, Edoardo Nicolò, Consonni, Monica, Iazzolino, Barbara, Torre, Silvia, Solca, Federica, Faltracco, Veronica, Telesca, Alessandra, Palumbo, Francesca, Dalla Bella, Eleonora, Bersano, Enrica, Riva, Nilo, Verde, Federico, Messina, Stefano, Doretti, Alberto, Maranzano, Alessio, Morelli, Claudia, Calvo, Andrea, Silani, Vincenzo, Lauria, Giuseppe, Chiò, Adriano, and Ticozzi, Nicola

Published
2024
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8. Clinical and neuroanatomical characterization of the semantic behavioral variant of frontotemporal dementia in a multicenter Italian cohort

Author

Ghirelli, Alma, Spinelli, Edoardo Gioele, Canu, Elisa, Basaia, Silvia, Castelnovo, Veronica, Cecchetti, Giordano, Sibilla, Elisa, Domi, Teuta, Magnani, Giuseppe, Caso, Francesca, Caroppo, Paola, Prioni, Sara, Villa, Cristina, Rossi, Giacomina, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Ticozzi, Nicola, Silani, Vincenzo, Filippi, Massimo, and Agosta, Federica

Published
2024
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9. Reliable change indices for the Italian version of the Montreal Cognitive Assessment (MoCA) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, Solca, Federica, Torre, Silvia, Curti, Beatrice, De Luca, Giulia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Olivero, Marco, Morelli, Claudia, Doretti, Alberto, Maderna, Luca, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Ruggiero, Fabiana, Mellace, Denise, Marfoli, Angelica, De Sandi, Angelica, Priori, Alberto, Pravettoni, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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13. Advancing Italian Biomedical Information Extraction with Transformers-based Models: Methodological Insights and Multicenter Practical Application

Author

Crema, Claudio, Buonocore, Tommaso Mario, Fostinelli, Silvia, Parimbelli, Enea, Verde, Federico, Fundarò, Cira, Manera, Marina, Ramusino, Matteo Cotta, Capelli, Marco, Costa, Alfredo, Binetti, Giuliano, Bellazzi, Riccardo, and Redolfi, Alberto

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, I.2.7, J.3
Abstract

The introduction of computerized medical records in hospitals has reduced burdensome activities like manual writing and information fetching. However, the data contained in medical records are still far underutilized, primarily because extracting data from unstructured textual medical records takes time and effort. Information Extraction, a subfield of Natural Language Processing, can help clinical practitioners overcome this limitation by using automated text-mining pipelines. In this work, we created the first Italian neuropsychiatric Named Entity Recognition dataset, PsyNIT, and used it to develop a Transformers-based model. Moreover, we collected and leveraged three external independent datasets to implement an effective multicenter model, with overall F1-score 84.77%, Precision 83.16%, Recall 86.44%. The lessons learned are: (i) the crucial role of a consistent annotation process and (ii) a fine-tuning strategy that combines classical methods with a "low-resource" approach. This allowed us to establish methodological guidelines that pave the way for Natural Language Processing studies in less-resourced languages., Comment: 2 figures, 6 tables, Supplementary Notes included

Published
2023
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14. Validity, diagnostics and feasibility of the Italian version of the Montreal Cognitive Assessment (MoCA) in Huntington’s disease

Author

Aiello, Edoardo Nicolò, Solca, Federica, Torre, Silvia, Lafronza, Annalisa, Maranzano, Alessio, Bonetti, Ruggero, Scheveger, Francesco, Maffi, Sabrina, Ceccarelli, Consuelo, Scocchia, Marta, Casella, Melissa, Verde, Federico, Migliore, Simone, Silani, Vincenzo, Ticozzi, Nicola, Squitieri, Ferdinando, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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15. The value of routine blood work-up in clinical stratification and prognosis of patients with amyotrophic lateral sclerosis

Author

Gentile, Francesco, Maranzano, Alessio, Verde, Federico, Bettoni, Veronica, Colombo, Eleonora, Doretti, Alberto, Olivero, Marco, Scheveger, Francesco, Colombrita, Claudia, Bulgarelli, Ilaria, Spinelli, Edoardo Gioele, Torresani, Erminio, Messina, Stefano, Maderna, Luca, Agosta, Federica, Morelli, Claudia, Filippi, Massimo, Silani, Vincenzo, and Ticozzi, Nicola

Published
2024
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16. Correction: Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, D’Iorio, Alfonsina, Solca, Federica, Torre, Silvia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Maderna, Luca, Morelli, Claudia, Doretti, Alberto, Amboni, Marianna, Vitale, Carmine, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Zirone, Eleonora, Priori, Alberto, Pravettoni, Gabriella, Santangelo, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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18. Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

Author

Baloh, Robert H., Bowser, Robert, Brady, Christopher B., Brice, Alexis, Broach, James, Camu, William, Chia, Ruth, Chio, Adriano, Cooper-Knock, John, Cusi, Daniele, Ding, Jinhui, Drepper, Carsten, Drory, Vivian E., Dunckley, Travis L., Feldman, Eva, Floeter, Mary Kay, Fratta, Pietro, Gerhard, Glenn, Gibbs, J. Raphael, Gibson, Summer B., Glass, Jonathan D., Goutman, Stephen A., Hardy, John, Harms, Matthew B., Heiman-Patterson, Terry D., Jansson, Lilja, Kirby, Janine, Laaksovirta, Hannu, Landers, John E., Landi, Francesco, Le Ber, Isabelle, Lumbroso, Serge, Guissart, Claire, MacGowan, Daniel JL., Maragakis, Nicholas J., Mora, Gabriele, Mouzat, Kevin, Myllykangas, Liisa, Orrell, Richard W., Ostrow, Lyle W., Pickering-Brown, Stuart, Pioro, Erik P., Pulst, Stefan M., Ravits, John M., Renton, Alan E., Robberecht, Wim, Rogaeva, Ekaterina, Rothstein, Jeffrey D., Salvi, Erika, Scholz, Sonja W., Sendtner, Michael, Shaw, Pamela J., Sidle, Katie C., Simmons, Zachary, Stone, David J., Tienari, Pentti J., Traynor, Bryan J., Trojanowski, John Q., Troncoso, Juan C., Valori, Miko, Van Damme, Philip, Van Deerlin, Vivianna M., Van Den Bosch, Ludo, Zinman, Lorne, Angelocola, Stefania M., Ausiello, Francesco P., Barberis, Marco, Bartolomei, Ilaria, Battistini, Stefania, Bersano, Enrica, Bisogni, Giulia, Borghero, Giuseppe, Brunetti, Maura, Cabona, Corrado, Calvo, Andrea, Canale, Fabrizio, Canosa, Antonio, Cantisani, Teresa A., Capasso, Margherita, Caponnetto, Claudia, Cardinali, Patrizio, Carrera, Paola, Casale, Federico, Colletti, Tiziana, Conforti, Francesca L., Conte, Amelia, Conti, Elisa, Corbo, Massimo, Cuccu, Stefania, Bella, Eleonora Dalla, D'Errico, Eustachio, DeMarco, Giovanni, Dubbioso, Raffaele, Ferrarese, Carlo, Ferraro, Pilar M., Filippi, Massimo, Fini, Nicola, Floris, Gianluca, Fuda, Giuseppe, Gallone, Salvatore, Gianferrari, Giulia, Giannini, Fabio, Grassano, Maurizio, Greco, Lucia, Iazzolino, Barbara, Introna, Alessandro, La Bella, Vincenzo, Lattante, Serena, Lauria, Giuseppe, Liguori, Rocco, Logroscino, Giancarlo, Logullo, Francesco O., Lunetta, Christian, Mandich, Paola, Mandrioli, Jessica, Manera, Umberto, Manganelli, Fiore, Marangi, Giuseppe, Marinou, Kalliopi, Marrosu, Maria Giovanna, Martinelli, Ilaria, Messina, Sonia, Moglia, Cristina, Monsurrò, Maria Rosaria, Mosca, Lorena, Murru, Maria R., Origone, Paola, Passaniti, Carla, Petrelli, Cristina, Petrucci, Antonio, Pirisi, Angelo, Pozzi, Susanna, Pugliatti, Maura, Quattrini, Angelo, Ricci, Claudia, Riolo, Giulia, Riva, Nilo, Russo, Massimo, Sabatelli, Mario, Salamone, Paolina, Salivetto, Marco, Salvi, Fabrizio, Santarelli, Marialuisa, Sbaiz, Luca, Sideri, Riccardo, Simone, Isabella, Simonini, Cecilia, Spataro, Rossella, Tanel, Raffaella, Tedeschi, Gioacchino, Ticca, Anna, Torriello, Antonella, Tranquilli, Stefania, Tremolizzo, Lucio, Trojsi, Francesca, Vasta, Rosario, Vacchiano, Veria, Vita, Giuseppe, Volanti, Paolo, Zollino, Marcella, Zucchi, Elisabetta, Silani, Vincenzo, Fogh, Isabella, Ticozzi, Nicola, Ratti, Antonia, Tiloca, Cinzia, Peverelli, Silvia, Gellera, Cinzia, Pinter, Giuseppe Lauria, Taroni, Franco, Pensato, Viviana, Castellotti, Barbara, Comi, Giacomo P., Corti, Stefania, Del Bo, Roberto, Cereda, Cristina, Ceroni, Mauro, Gagliardi, Stella, Corrado, Lucia, Mazzini, Letizia, Sorarù, Gianni, Raggi, Flavia, Siciliano, Gabriele, Simoncini, Costanza, Lo Gerfo, Annalisa, Filosto, Massimiliano, Inghilleri, Maurizio, Ferlini, Alessandra, Corcia, Philippe, Couratier, Philippe, Vourc'h, Patrick, Hardiman, Orla, McLaughlin, Russell, Gotkine, Marc, Drory, Vivian, van den Veldink, Jan H., Berg, Leonard H., de Carvalho, Mamede, Mora Pardina, Jesus S., Povedano, Monica, Andersen, Peter, Weber, Markus, Başak, Ayşe Nazlı, Al-Chalabi, Ammar, Shaw, Chris, Morrison, Karen E., Adeleye, Adelani, Alba, Camille, Bacikova, Dagmar, Dalgard, Clifton L., Hupalo, Daniel N., McGrath Martinez, Elisa, Soltis, Anthony R., Sukumar, Gauthaman, Viollet, Coralie, Wilkerson, Matthew D., Saez-Atienzar, Sara, Souza, Cleide dos Santos, Beal, Selina N., Lorenzini, Ileana, Huang, Ruili, Levy, Jennifer, Burciu, Camelia, Jones, Ashley, Dewan, Ramita, van Vugt, Joke J.F.A., van Rheenen, Wouter, Tunca, Ceren, Bayraktar, Elif, Xia, Menghang, Iacoangeli, Alfredo, Shatunov, Aleksey, Verde, Federico, Kenna, Kevin, Al Khleifat, Ahmad, Opie-Martin, Sarah, Piccinelli, Stefano Cotti, Padovani, Alessandro, Galimberti, Daniela, Serpente, Maria, Fenoglio, Chiara, Scarpini, Elio, Curtis, Charles J., Lee, Sang Hyuck, Chung, Raymond, Patel, Hamel, Cooper-Knock, Johnathan, Breen, Gerome, Dobson, Richard J.B., van den Berg, Leonard H., D’Alfonso, Sandra, Chandran, Siddharthan, Pal, Suvankar, Johnson, Kory, Doucet-O’Hare, Tara, Pasternack, Nicholas, Wang, Tongguang, Nath, Avindra, Veldink, Jan H., Chiò, Adriano, Sattler, Rita, Shaw, Christopher E., and Ferraiuolo, Laura

Published
2024
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24. Equating norms between the ALS Cognitive Behavioral Screen (ALS-CBS™) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in non-demented ALS patients

Author

Aiello, Edoardo Nicolò, Solca, Federica, Greco, Lucia Catherine, Torre, Silvia, Carelli, Laura, Morelli, Claudia, Doretti, Alberto, Colombo, Eleonora, Messina, Stefano, Pain, Debora, Radici, Alice, Lizio, Andrea, Casiraghi, Jacopo, Cerri, Federica, Woolley, Susan, Murphy, Jennifer, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Sansone, Valeria Ada, Lunetta, Christian, Silani, Vincenzo, Ticozzi, Nicola, and Poletti, Barbara

Published
2023
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26. Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, D’Iorio, Alfonsina, Solca, Federica, Torre, Silvia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Maderna, Luca, Morelli, Claudia, Doretti, Alberto, Amboni, Marianna, Vitale, Carmine, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Zirone, Eleonora, Priori, Alberto, Pravettoni, Gabriella, Santangelo, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2023
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28. Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™)

Author

Aiello, Edoardo Nicolò, Greco, Lucia Catherine, La Tona, Antonino, Solca, Federica, Torre, Silvia, Carelli, Laura, Pain, Debora, Radici, Alice, Lizio, Andrea, Casiraghi, Jacopo, Cerri, Federica, Brugnera, Agostino, Compare, Angelo, Woolley, Susan, Murphy, Jennifer, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Silani, Vincenzo, Ticozzi, Nicola, Lunetta, Christian, Sansone, Valeria Ada, and Poletti, Barbara

Published
2023
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29. Digital health and Clinical Patient Management System (CPMS) platform utility for data sharing of neuromuscular patients: the Italian EURO-NMD experience

Author

Fortunato, Fernanda, Bianchi, Francesca, Ricci, Giulia, Torri, Francesca, Gualandi, Francesca, Neri, Marcella, Farnè, Marianna, Giannini, Fabio, Malandrini, Alessandro, Volpi, Nila, Lopergolo, Diego, Silani, Vincenzo, Ticozzi, Nicola, Verde, Federico, Pareyson, Davide, Fenu, Silvia, Bonanno, Silvia, Nigro, Vincenzo, Peduto, Cristina, D’Ambrosio, Paola, Zeuli, Roberta, Zanobio, Mariateresa, Picillo, Esther, Servidei, Serenella, Primiano, Guido, Sancricca, Cristina, Sciacco, Monica, Brusa, Roberta, Filosto, Massimiliano, Cotti Piccinelli, Stefano, Pegoraro, Elena, Mongini, Tiziana, Solero, Luca, Gadaleta, Giulio, Brusa, Chiara, Minetti, Carlo, Bruno, Claudio, Panicucci, Chiara, Sansone, Valeria A., Lunetta, Christian, Zanolini, Alice, Toscano, Antonio, Pugliese, Alessia, Nicocia, Giulia, Bertini, Enrico, Catteruccia, Michela, Diodato, Daria, Atalaia, Antonio, Evangelista, Teresinha, Siciliano, Gabriele, and Ferlini, Alessandra

Published
2023
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42. QSM-detected iron accumulation in the cerebellar gray matter is selectively associated with executive dysfunction in non-demented ALS patients.

Author

Aiello, Edoardo Nicolò, Contarino, Valeria Elisa, Conte, Giorgio, Solca, Federica, Curti, Beatrice, Maranzano, Alessio, Torre, Silvia, Casale, Silvia, Doretti, Alberto, Colombo, Eleonora, Verde, Federico, Silani, Vincenzo, Chunlei Liu, Cinnante, Claudia, Triulzi, Fabio Maria, Morelli, Claudia, Poletti, Barbara, and Ticozzi, Nicola

Subjects
EXECUTIVE function, AMYOTROPHIC lateral sclerosis, GRAY matter (Nerve tissue), MEMORY span, CEREBELLAR cortex
Abstract

Background: This study aimed to assess whether quantitative susceptibility imaging (QSM)-based measures of iron accumulation in the cerebellum predict cognitive and behavioral features in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: A total of ALS patients underwent 3-T MRI and a clinical assessment using the ALS Functional Rating Scale-Revised (ALSFRS-R) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Regression models were applied to each subscale of the cognitive section of the ECAS and the ECASCarer Interview to examine the effect of QSM-based measures in white and gray matter (WM; GM) of the cerebellum, separately for right, left, and bilateral cerebellar regions of interest (ROIs). These effects were compared to those of cerebellar volumetrics in WM/GM, right and left hemispheres while controlling for demographics, disease status, and total intracranial volume. Results: Higher QSM measures of the cerebellar GM on the left, right, and bilateral sides significantly predicted (ps = 0.003) a greater number of errors on the executive functioning (EF) subscale of the ECAS (ECAS-EF). Moreover, higher GM-related, QSM measures of the cerebellum were associated with an increased probability of a below-cut-off performance on the ECAS-EF (ps = 0.024). No significant effects were observed for QSM measures of the cerebellar WM or for volumetric measures on the ECAS-EF. Other ECAS measures showed no significant effects. Bilateral QSM measures of the cerebellar GM also selectively predicted performance on backward digit span and social cognition tasks. Discussion: Iron accumulation within the cerebellar GM, particularly in the cerebellar cortices, may be associated with executive functioning deficits in nondemented ALS patients. Therefore, QSM-based measures could be useful for identifying the neural correlates of extra-motor cognitive deficits in ALS patients. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Author

Nicolas, Aude, Kenna, Kevin P, Renton, Alan E, Ticozzi, Nicola, Faghri, Faraz, Chia, Ruth, Dominov, Janice A, Kenna, Brendan J, Nalls, Mike A, Keagle, Pamela, Rivera, Alberto M, van Rheenen, Wouter, Murphy, Natalie A, van Vugt, Joke JFA, Geiger, Joshua T, Van der Spek, Rick A, Pliner, Hannah A, Shankaracharya, Smith, Bradley N, Marangi, Giuseppe, Topp, Simon D, Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D, Kenna, Aoife, ITALSGEN Consortium, Mora, Gabriele, Calvo, Andrea, Mazzini, Letizia, Riva, Nilo, Mandrioli, Jessica, Caponnetto, Claudia, Battistini, Stefania, Volanti, Paolo, La Bella, Vincenzo, Conforti, Francesca L, Borghero, Giuseppe, Messina, Sonia, Simone, Isabella L, Trojsi, Francesca, Salvi, Fabrizio, Logullo, Francesco O, D'Alfonso, Sandra, Corrado, Lucia, Capasso, Margherita, Ferrucci, Luigi, Genomic Translation for ALS Care (GTAC) Consortium, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Goldstein, David B, ALS Sequencing Consortium, Gitler, Aaron D, Harris, Tim, Myers, Richard M, NYGC ALS Consortium, Phatnani, Hemali, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C, Answer ALS Foundation, Kaye, Julia, Finkbeiner, Steven, Wyman, Stacia K, LeNail, Alex, Lima, Leandro, Fraenkel, Ernest, Svendsen, Clive N, Thompson, Leslie M, Van Eyk, Jennifer E, Berry, James D, Miller, Timothy M, Kolb, Stephen J, Cudkowicz, Merit, Baxi, Emily, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Benatar, Michael, Taylor, J Paul, Rampersaud, Evadnie, Wu, Gang, Wuu, Joanne, SLAGEN Consortium, Lauria, Giuseppe, Verde, Federico, Fogh, Isabella, Tiloca, Cinzia, Comi, Giacomo P, Sorarù, Gianni, Cereda, Cristina, French ALS Consortium, Corcia, Philippe, Laaksovirta, Hannu, Myllykangas, Liisa, Jansson, Lilja, Valori, Miko, Ealing, John, Hamdalla, Hisham, Rollinson, Sara, Pickering-Brown, Stuart, and Orrell, Richard W

Subjects
ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium, Project MinE ALS Sequencing Consortium, Humans, Amyotrophic Lateral Sclerosis, Cohort Studies, Amino Acid Sequence, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study, Young Adult, Loss of Function Mutation, Kinesins, ALS, GWAS, KIF5A, WES, WGS, axonal transport, cargo, Brain Disorders, Genetics, Human Genome, Rare Diseases, Neurosciences, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Neurological, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.

Published
2018

45. Unleashing the potential of mRNA therapeutics for inherited neurological diseases

Author

Monfrini, Edoardo, primary, Baso, Giacomo, additional, Ronchi, Dario, additional, Meneri, Megi, additional, Gagliardi, Delia, additional, Quetti, Lorenzo, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Ratti, Antonia, additional, Di Fonzo, Alessio, additional, Comi, Giacomo P, additional, Ottoboni, Linda, additional, and Corti, Stefania, additional

Published
2024
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46. Longitudinal feasibility of the Montreal Cognitive Assessment (MoCA) in non-demented ALS patients

Author

Aiello, Edoardo Nicolò, primary, Solca, Federica, additional, Torre, Silvia, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, De Lorenzo, Alberto, additional, Patisso, Valerio, additional, Treddenti, Mauro, additional, Curti, Beatrice, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Verde, Federico, additional, Ferrucci, Roberta, additional, Barbieri, Sergio, additional, Ruggiero, Fabiana, additional, Priori, Alberto, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, and Poletti, Barbara, additional

Published
2024
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47. Clinical and Neuroanatomical Characterization of the Semantic Behavioural Variant of Frontotemporal Dementia in a Multicentre Italian Cohort (P4-9.004)

Author

Ghirelli, Alma, primary, Spinelli, Edoardo, additional, Canu, Elisa, additional, Basaia, Silvia, additional, Castelnovo, Veronica, additional, Cecchetti, Giordano, additional, Sibilla, Elisa, additional, Magnani, Giuseppe, additional, Caso, Francesca, additional, Caroppo, Paola, additional, Prioni, Sara, additional, Villa, Cristina, additional, Tremolizzo, Lucio, additional, Appollonio, Ildebrando, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Silani, Vincenzo, additional, Filippi, Massimo, additional, and Agosta, Federica, additional

Published
2024
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48. Breaking Diagnostic Barriers: NODDI-Machine learning Fusion for FTD Differential Diagnosis (S1.007)

Author

Agosta, Federica, primary, Basaia, Silvia, additional, Pisano, Stefano, additional, Canu, Elisa, additional, Spinelli, Edoardo, additional, Cecchetti, Giordano, additional, Ghirelli, Alma, additional, Sibilla, Elisa, additional, Magnani, Giuseppe, additional, Caso, Francesca, additional, Caroppo, Paola, additional, Prioni, Sara, additional, Villa, Cristina, additional, Tremolizzo, Lucio, additional, Appollonio, Ildebrando, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Silani, Vincenzo, additional, and Filippi, Massimo, additional

Published
2024
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49. Next-generation sequencing application to investigate skeletal muscle channelopathies in a large cohort of Italian patients

Author

Brugnoni, Raffaella, Maggi, Lorenzo, Canioni, Eleonora, Verde, Federico, Gallone, Annamaria, Ariatti, Alessandra, Filosto, Massimiliano, Petrelli, Cristina, Logullo, Francesco Ottavio, Esposito, Marcello, Ruggiero, Lucia, Tonin, Paola, Riguzzi, Pietro, Pegoraro, Elena, Torri, Francesca, Ricci, Giulia, Siciliano, Gabriele, Silani, Vincenzo, Merlini, Luciano, De Pasqua, Silvia, Liguori, Rocco, Pini, Antonella, Mariotti, Caterina, Moroni, Isabella, Imbrici, Paola, Desaphy, Jean-Francois, Mantegazza, Renato, and Bernasconi, Pia

Published
2021
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50. Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario

Author

Crema, Claudio, Verde, Federico, Tiraboschi, Pietro, Marra, Camillo, Arighi, Andrea, Fostinelli, Silvia, Giuffre, Guido Maria, Maschio, Vera Pacoova Dal, L'Abbate, Federica, Solca, Federica, Poletti, Barbara, Silani, Vincenzo, Rotondo, Emanuela, Borracci, Vittoria, Vimercati, Roberto, Crepaldi, Valeria, Inguscio, Emanuela, Filippi, Massimo, Caso, Francesca, Rosati, Alessandra Maria, Quaranta, Davide, Binetti, Giuliano, Pagnoni, Ilaria, Morreale, Manuela, Burgio, Francesca, Maserati, Michelangelo Stanzani, Capellari, Sabina, Pardini, Matteo, Girtler, Nicola, Piras, Federica, Piras, Fabrizio, Lalli, Stefania, Perdixi, Elena, Lombardi, Gemma, Tella, Sonia Di, Costa, Alfredo, Capelli, Marco, Fundaro, Cira, Manera, Marina, Muscio, Cristina, Pellencin, Elisa, Lodi, Raffaele, Tagliavini, Fabrizio, and Redolfi, Alberto

Abstract

The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared to manual recording. Nevertheless, the potential of the information contained within medical records remains largely untapped, mostly due to the time and effort required to extract data from unstructured documents. Natural Language Processing (NLP) represents a promising solution to this challenge, as it enables the use of automated text-mining tools for clinical practitioners. In this work, we present the architecture of the Virtual Dementia Institute (IVD), a consortium of sixteen Italian hospitals, using the NLP Extraction and Management Tool (NEMT), a (semi-) automated end-to-end pipeline that extracts relevant information from clinical documents and stores it in a centralized REDCap database. After defining a common Case Report Form (CRF) across the IVD hospitals, we implemented NEMT, the core of which is a Question Answering Bot (QABot) based on a modern NLP model. This QABot is fine-tuned on thousands of examples from IVD centers. Detailed descriptions of the process to define a common minimum dataset, Inter-Annotator Agreement calculated on clinical documents, and NEMT results are provided. The best QABot performance show an Exact Match score (EM) of 78.1%, a F1-score of 84.7%, a Lenient Accuracy (LAcc) of 0.834, and a Mean Reciprocal Rank (MRR) of 0.810. EM and F1 scores outperform the same metrics obtained with ChatGPTv3.5 (68.9% and 52.5%, respectively). With NEMT the IVD has been able to populate a database that will contain data from thousands of Italian patients, all screened with the same procedure. NEMT represents an efficient tool that paves the way for medical information extraction and exploitation for new research studies.

Published
2024
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