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2. Comparison of Outcomes and Mortality in Patients Having Left Ventricular Assist Device Implanted Early -vs- Late After Diagnosis of Cardiomyopathy

Author

Chen, Elisabeth, Nesseler, Nicolas, Martins, Raphaël P., Goéminne, Céline, Vincentelli, André, Delmas, Clément, Porterie, Jean, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Rouvière, Philippe, Michel, Magali, Sénage, Thomas, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Baudry, Guillaume, Litzler, Pierre-Yves, Anselme, Frédéric, Blanchart, Katrien, Babatasi, Gerard, Garnier, Fabien, Bielefeld, Marie, Radu, Costin, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Bories, Marie-Cécile, Baudinaud, Pierre, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, Flécher, Erwan, and Galand, Vincent

Published
2021
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3. Septuagenarian population has similar survival and outcomes to younger patients after left ventricular assist device implantation

Author

Galand, Vincent, Flécher, Erwan, Chabanne, Céline, Lelong, Bernard, Goéminne, Céline, Vincentelli, André, Delmas, Clément, Dambrin, Camille, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Frapier, Jean Marc, Michel, Magali, Sénage, Thomas, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litlzer, Pierre Yves, Anselme, Frédéric, Babatasi, Gerard, Plane, Anne Flore, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Radu, Costin, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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4. Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices

Author

Galand, Vincent, Flécher, Erwan, Lelong, Bernard, Chabanne, Céline, Charton, Marion, Goéminne, Céline, Vincentelli, André, Porterie, Jean, Delmas, Clément, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Michel, Magali, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yves, Anselme, Frédéric, Blanchart, Katrien, Babatasi, Gerard, Garnier, Fabien, Bielefeld, Marie, Radu, Costin, Hamon, David, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Bories, Marie-Cécile, Varlet, Emilie, Vanhuyse, Fabrice, Sadoul, Nicolas, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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5. Outcomes of Left Ventricular Assist Device Implantation in Patients With Uncommon Etiology Cardiomyopathy

Author

Galand, Vincent, Flécher, Erwan, Chabanne, Céline, Lelong, Bernard, Goéminne, Céline, Vincentelli, André, Delmas, Clément, Dambrin, Camille, Picard, François, Sacher, Frédéric, Kindo, Michel, Minh, Tam Hoang, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Michel, Magali, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Ghodhbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yvesl, Anselme, Frédéric, Babatasi, Gerard, Blanchart, Katrien, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D'Ostrevy, Nicolas, Varlet, Emilie, Jouan, Jérôme, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, and Martins, Raphaël P.

Published
2020
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6. Risk factors and prognostic impact of left ventricular assist device–associated infections

Author

Tattevin, Pierre, Flécher, Erwan, Auffret, Vincent, Leclercq, Christophe, Boulé, Stéphane, Vincentelli, André, Dambrin, Camille, Delmas, Clément, Barandon, Laurent, Veniard, Vincent, Kindo, Michel, Cardi, Thomas, Gaudard, Philippe, Rouvière, Philippe, Sénage, Thomas, Jacob, Nicolas, Defaye, Pascal, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Grinberg, Daniel, Savouré, Arnaud, Litzler, Pierre-Yves, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Bernard, Louis, Bourguignon, Thierry, Eschalier, Romain, D'Ostrevy, Nicolas, Jouan, Jérôme, Varlet, Emilie, Vanhuyse, Fabrice, Blangy, Hugues, Martins, Raphaël P., and Galand, Vincent

Published
2019
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7. Acute Pulmonary Edema After Double Mechanical Valve Replacement

Author

Poulat, Audrey, primary, Verdonk, Constance, additional, Para, Marylou, additional, Jendoubi, Ali, additional, Khzouri, Takoua, additional, Senemaud, Jean Nicolas, additional, Castier, Yves, additional, Richaud, Rainu, additional, Ou, Phalla, additional, Iung, Bernard, additional, and Nataf, Patrick, additional

Published
2024
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8. Predictors and Clinical Impact of Late Ventricular Arrhythmias in Patients With Continuous-Flow Left Ventricular Assist Devices

Author

Galand, Vincent, Flécher, Erwan, Auffret, Vincent, Boulé, Stéphane, Vincentelli, André, Dambrin, Camille, Mondoly, Pierre, Sacher, Frédéric, Nubret, Karine, Kindo, Michel, Cardi, Thomas, Gaudard, Philippe, Rouvière, Philippe, Michel, Magali, Gourraud, Jean-Baptiste, Defaye, Pascal, Chavanon, Olivier, Verdonk, Constance, Ghodbane, Walid, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litzler, Pierre-Yves, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Radu, Costin, Pierre, Bertrand, Bourguignon, Thierry, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Verhoye, Jean-Philippe, Leclercq, Christophe, and Martins, Raphaël P.

Published
2018
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13. Suicide Attempts Among LVAD Recipients: Real-Life Data From the ASSIST-ICD Study

Author

Charton, Marion, Flécher, Erwan, Leclercq, Christophe, Delmas, Clément, Dambrin, Camille, Goeminne, Céline, Vincentelli, André, Michel, Magali, Lehelias, Laurence, Verdonk, Constance, Para, Marylou, Pozzi, Matteo, Obadia, Jean-François, Boignard, Aude, Chavanon, Olivier, Barandon, Laurent, Nubret, Karine, Kindo, Michel, Minh, Tam Hoang, Gaudard, Philippe, Pelcé, Edeline, Gariboldi, Vlad, Litzler, Pierre-Yves, Anselme, Frédéric, Babatasi, Gerard, Belin, Annette, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Lellouche, Nicolas, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D’Ostrevy, Nicolas, Bories, Marie-Cécile, Jouan, Jérôme, Vanhuyse, Fabrice, Blangy, Hugues, Doucerain, Julie, Martins, Raphael P., and Galand, Vincent

Published
2020
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17. Elucidating tricuspid Doppler signal interpolation and its implication for assessing pulmonary hypertension

Author

Dual, Seraina A., primary, Verdonk, Constance, additional, Amsallem, Myriam, additional, Pham, Jonathan, additional, Obasohan, Courtney, additional, Nataf, Patrick, additional, McElhinney, Doff B., additional, Arunamata, Alisa, additional, Kuznetsova, Tatiana, additional, Zamanian, Roham, additional, Feinstein, Jeffrey A., additional, Marsden, Alison, additional, and Haddad, François, additional

Published
2022
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18. Elucidating tricuspid Doppler signal interpolation and its implication for assessing pulmonary hypertension

Author

Dual, Seraina A., Verdonk, Constance, Amsallem, Myriam, Pham, Jonathan, Obasohan, Courtney, Nataf, Patrick, McElhinney, Doff B., Arunamata, Alisa, Kuznetsova, Tatiana, Zamanian, Roham, Feinstein, Jeffrey A., Marsden, Alison, Haddad, François, Dual, Seraina A., Verdonk, Constance, Amsallem, Myriam, Pham, Jonathan, Obasohan, Courtney, Nataf, Patrick, McElhinney, Doff B., Arunamata, Alisa, Kuznetsova, Tatiana, Zamanian, Roham, Feinstein, Jeffrey A., Marsden, Alison, and Haddad, François

Abstract

Doppler echocardiography plays a central role in the assessment of pulmonary hypertension (PAH). We aim to improve quality assessment of systolic pulmonary arterial pressure (SPAP) by applying a cubic polynomial interpolation to digitized tricuspid regurgitation (TR) waveforms. Patients with PAH and advanced lung disease were divided into three cohorts: a derivation cohort (n = 44), a validation cohort (n = 71), an outlier cohort (n = 26), and a non-PAH cohort (n = 44). We digitized TR waveforms and analyzed normalized duration, skewness, kurtosis, and first and second derivatives of pressure. Cubic polynomial interpolation was applied to three physiology-driven phases: the isovolumic phase, ejection phase, and “shoulder” point phase. Coefficients of determination and a Bland−Altman analysis was used to assess bias between methods. The cubic polynomial interpolation of the TR waveform correlated strongly with expert read right ventricular systolic pressure (RVSP) with R2 > 0.910 in the validation cohort. The biases when compared to invasive SPAP measured within 24 h were 6.03 [4.33; 7.73], −2.94 [1.47; 4.41], and −3.11 [−4.52; −1.71] mmHg, for isovolumic, ejection, and shoulder point interpolations, respectively. In the outlier cohort with more than 30% difference between echocardiographic estimates and invasive SPAP, cubic polynomial interpolation significantly reduced underestimation of RVSP. Cubic polynomial interpolation of the TR waveform based on isovolumic or early ejection phase may improve RVSP estimates., QC 20230607

Published
2022
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19. Outcome of Temporary Circulatory Support As a Bridge-to-Left Ventricular Assist Device Strategy in Cardiogenic Shock Patients

Author

Bidaut, Auriane, primary, Flécher, Erwan, additional, Nesseler, Nicolas, additional, Bounader, Karl, additional, Vincentelli, André, additional, Moussa, Mouhammed, additional, Delmas, Clément, additional, Porterie, Jean, additional, Nubret, Karine, additional, Pernot, Mathieu, additional, Kindo, Michel, additional, Schneider, Clément, additional, Gaudard, Philippe, additional, Rouvière, Philippe, additional, Michel, Magali, additional, Sénage, Thomas, additional, Boignard, Aude, additional, Chavanon, Olivier, additional, Verdonk, Constance, additional, Para, Marylou, additional, Maille, Baptiste, additional, Gariboldi, Vlad, additional, Pozzi, Matteo, additional, Hugon-Vallet, Elisabeth, additional, Litzler, Pierre-Yves, additional, Anselme, Frédéric, additional, Blanchart, Katrien, additional, Babatasi, Gerard, additional, Bielefeld, Marie, additional, Grosjean, Sandrine, additional, Radu, Costin, additional, Hamon, David, additional, Bourguignon, Thierry, additional, Genet, Thibaud, additional, Eschalier, Romain, additional, D’Ostrevy, Nicolas, additional, Nougue, Hélène, additional, Martin, Anne Cécile, additional, Vanhuyse, Fabrice, additional, Blangy, Hugues, additional, Leclercq, Christophe, additional, Martins, Raphael P., additional, and Galand, Vincent, additional

Published
2022
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20. Characteristics and outcome of ambulatory heart failure patients receiving a left ventricular assist device

Author

Baudry, Guillaume, Nesseler, Nicolas, Flecher, Erwan, Vincentelli, André, Goeminne, Céline, Delmas, Clément, Porterie, Jean, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Rouvière, Philippe, Gaudard, Philippe, Michel, Magali, Senage, Thomas, Boignard, Aude, Chavanon, Olivier, Para, Marylou, Verdonk, Constance, Pelcé, Edeline, Gariboldi, Vlad, Anselme, Frederic, Litzler, Pierre‐Yves, Blanchart, Katrien, Babatasi, Gerard, Bielefeld, Marie, Bouchot, Olivier, Hamon, David, Lellouche, Nicolas, Bailleul, Xavier, Genet, Thibaud, Eschalier, Romain, d'Ostrevy, Nicolas, Bories, Marie‐Cécile, Akar, Ramzi Abi, Blangy, Hugues, Vanhuyse, Fabrice, Obadia, Jean François, Galand, Vincent, Pozzi, Matteo, Hospices Civils de Lyon (HCL), Hôpital Louis Pradel [CHU - HCL], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Coeur Poumon [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Toulouse [Toulouse], Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Université de Bordeaux Ségalen [Bordeaux 2], Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Michallon, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Charles Nicolle [Rouen], Université de Caen Normandie (UNICAEN), Normandie Université (NU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Henri Mondor, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Clermont-Ferrand, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Nancy (CHU Nancy), Hôpital Brabois, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Rouen, Normandie Université (NU)-Normandie Université (NU), CHU Henri Mondor [Créteil], The authors received no financial support for the research, authorship, and/or publication of this article., MORNET, Dominique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
Heart Failure, Male, Advanced heart failure, [SDV]Life Sciences [q-bio], Left ventricular assist device, Original Articles, Middle Aged, Outcome measures, [SDV] Life Sciences [q-bio], Survival Rate, Heart failure medications, Treatment Outcome, Mechanical circulatory support, RC666-701, Humans, Diseases of the circulatory (Cardiovascular) system, Original Article, Heart-Assist Devices, Registries, Aged
Abstract

International audience; Aims: Despite regularly updated guidelines, there is still a delay in referral of advanced heart failure patients to mechanical circulatory support and transplant centres. We aimed to analyse characteristics and outcome of non-inotrope-dependent patients implanted with a left ventricular assist device (LVAD).Methods and results: The ASSIST-ICD registry collected LVAD data in 19 centres in France between February 2006 and December 2016. We used data of patients in Interagency Registry for Mechanically Assisted Circulatory Support Classes 4-7. The primary endpoint was survival analysis. Predictors of mortality were searched with multivariable analyses. A total of 303 patients (mean age 61.0 ± 9.9 years, male sex 86.8%) were included in the present analysis. Ischaemic cardiomyopathy was the leading heart failure aetiology (64%), and bridge to transplantation was the main implantation strategy (56.1%). The overall likelihood of being alive while on LVAD support or having a transplant at 1, 2, 3, and 5 years was 66%, 61.7%, 58.7%, and 55.1%, respectively. Age [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.00-1.05; P = 0.02], a concomitant procedure (HR 2.32, 95% CI 1.52-3.53; P < 0.0001), and temporary mechanical right ventricular support during LVAD implantation (HR 2.94, 95% CI 1.49-5.77; P = 0.002) were the only independent variables associated with mortality. Heart failure medications before or after LVAD implantation were not associated with survival.Conclusion: Ambulatory heart failure patients displayed unsatisfactory survival rates after LVAD implantation. A better selection of patients who can benefit from LVAD may help improving outcomes.

Published
2021
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22. Unexplained Dyspnea and Cardiopulmonary Exercise Testing: Rationale for a Dyspnea Clinic

Author

Nair, Pooja, primary, Christle, Jeffrey W, additional, Verdonk, Constance, additional, Cauwenberghs, Nichola, additional, Blumberg, Yair, additional, Sasportas, Laura S, additional, Zamanian, Roham, additional, Ashley, Euan, additional, Kuznetsova, Tatiana, additional, Myers, Jonathan, additional, Haddad, Francois, additional, and Amsallem, Myriam, additional

Published
2021
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23. Les patients âgés de plus de 70 ans implantés d’une assistance cardiaque ventriculaire gauche à flux continue ont des résultats et une survie similaires que les patients de moins de 70 ans

Author

Galand, Vincent, Flécher, Erwan, Chabanne, Céline, Lelong, Bernard, Goéminne, Céline, Vincentelli, André, Delmas, Clément, Dambrin, Camille, Nubret, Karine, Pernot, Mathieu, Kindo, Michel, Hoang Minh, Tam, Gaudard, Philippe, Frapier, Jean Marc, Michel, Magali, Sénage, Thomas, Boignard, Aude, Chavanon, Olivier, Verdonk, Constance, Para, Marylou, Pelcé, Edeline, Gariboldi, Vlad, Pozzi, Matteo, Obadia, Jean-François, Litlzer, Pierre Yves, Anselme, Frédéric, Babatasi, Gerard, Plane, Anne Flore, Garnier, Fabien, Bielefeld, Marie, Hamon, David, Radu, Costin, Bourguignon, Thierry, Genet, Thibaud, Eschalier, Romain, D’ostrevy, Nicolas, Bories, Marie-Cécile, Marijon, Eloi, Vanhuyse, Fabrice, Blangy, Hugues, Leclercq, Christophe, Martins, Raphaël, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Coeur Poumon [CHU Lille], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Fédération Française de Cardiologie, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Survival, Patients âgés, Left ventricular assist device, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Assistance cardiaque ventriculaire gauche, equipment and supplies, Elderly patients, LVAD-related complications, Septuagénaires, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Survie, Complications de LVAD, Septuagenarians, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Background: Left ventricular assist device (LVAD) implantation may be an attractive alternative therapeutic option for elderly patients with heart failure who are ineligible for heart transplantation.Aim: We aimed to describe the characteristics and outcomes of elderly patients (i.e. aged ≥ 70 years) receiving an LVAD.Methods; This observational study was conducted in 19 centres between 2006 and 2016. Patients were divided into two groups–younger (aged < 70 years) and elderly (aged ≥ 70 years), based on age at time of LVAD implantation.Results: A total of 652 patients were included in the final analysis, and 74 patients (11.3%) were aged ≥ 70 years at the time of LVAD implantation (maximal age 77.6 years). The proportion of elderly patients receiving an LVAD each year was constant, with a median of 10.6% (interquartile range 8.0–15.4%) per year, and all were implanted as destination therapy. Elderly and younger patients had similar durations of hospitalization in intensive care units and total lengths of hospital stays. Both age groups experienced similar rates of LVAD-related complications (i.e. stroke, bleeding, driveline infection and LVAD exchange), and the occurrence of LVAD complications did not impact survival in the elderly group compared with the younger group. Lastly, when compared with younger patients implanted as destination therapy, the elderly group also exhibited similar mid-term survival.Conclusion:This work strongly suggests that selected elderly adults can be scheduled for LVAD implantation.; Contexte: L’implantation d’une assistance cardiaque de longue durée (LVAD) peut être une séduisante alternative thérapeutique pour les patients insuffisants cardiaques âgés non éligible à une transplantation cardiaque.Objectif: Dans cette étude, nous décrivons les caractéristiques et résultats de l’implantation d’une assistance cardiaque mono-ventriculaire gauche chez des patients âgés de plus de 70 ans.Méthodes: Les patients implantés d’un LVAD dans 19 centres français entre 2006 et 2016 ont été inclus et divisés en deux groupes suivant l’âge à l’implantation (≥ 70 ou < 70 ans).Résultats: Un total de 652 patients ont été inclus et 74 (11,3 %) étaient âgés de plus de 70 ans à l’implantation du LVAD (maximal à 77,6 ans). La proportion de patients ayant ≥ 70 ans implanté d’un LVAD est constante chaque année avec une médiane de 10,6 % (8,0–15,4 %). Les 74 patients ont tous été implantés en thérapie définitive. Les deux groupes ont une durée d’hospitalisation (en réanimation et totale) similaire et développent un pourcentage identique de complications en lien avec le LVAD (accidents ischémiques, saignement, infection de câble, changement de LVAD). Le survenue d’une complication n’impact pas la survie chez les patients ≥ 70 ans par rapport au groupe < 70 ans. Enfin, parmi le sous-groupe de patients implantés en thérapie définitive, les deux populations (≥ 0 ou < 70 ans) ont une survie identique.Conclusion: Ce travail suggère que des patients insuffisants cardiaques âgés de plus de 70 ans et bien sélectionnés peuvent être de bons candidats à l’implantation d’un LVAD.

Published
2020
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24. Clinical manifestations and outcomes of coronavirus disease‐19 in heart transplant recipients: a multicentre case series with a systematic review and meta‐analysis

Author

Granger, Camille, primary, Guedeney, Paul, additional, Arnaud, Camille, additional, Guendouz, Soulef, additional, Cimadevilla, Claire, additional, Kerneis, Mathieu, additional, Kerneis, Caroline, additional, Zeitouni, Michel, additional, Verdonk, Constance, additional, Legeai, Camille, additional, Lebreton, Guillaume, additional, Leprince, Pascal, additional, Désiré, Eva, additional, Sorrentino, Sabato, additional, Silvain, Johanne, additional, Montalescot, Gilles, additional, Hazan, Fanny, additional, Varnous, Shaida, additional, and Dorent, Richard, additional

Published
2021
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26. Current results of left ventricular assist device therapy in France: the ASSIST-ICD registry

Author

Anselmi, Amedeo, primary, Galand, Vincent, primary, Vincentelli, André, primary, Boule, Stéphane, primary, Dambrin, Camille, primary, Delmas, Clément, primary, Barandon, Laurent, primary, Pernot, Mathieu, primary, Kindo, Michel, primary, Tam, Hoang Minh, primary, Gaudard, Philippe, primary, Rouviere, Philippe, primary, Senage, Thomas, primary, Michel, Magali, primary, Boignard, Aude, primary, Chavanon, Olivier, primary, Verdonk, Constance, primary, Para, Marylou, primary, Gariboldi, Vlad, primary, Pelce, Edeline, primary, Pozzi, Matteo, primary, Obadia, Jean-François, primary, Anselme, Frederic, primary, Litzler, Pierre-Yves, primary, Babatasi, Gerard, primary, Belin, Annette, primary, Garnier, Fabien, primary, Bielefeld, Marie, primary, Guihaire, Julien, primary, Kloeckner, Martin, primary, Radu, Costin, primary, Lellouche, Nicolas, primary, Bourguignon, Thierry, primary, Genet, Thibaud, primary, D’Ostrevy, Nicolas, primary, Duband, Benjamin, primary, Jouan, Jerome, primary, Bories, Marie Cécile, primary, Vanhuyse, Fabrice, primary, Blangy, Hugues, primary, Colas, Fabrice, primary, Verhoye, Jean-Philippe, primary, Martins, Raphael, primary, and Flecher, Erwan, primary

Published
2020
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28. Early Ventricular Arrhythmias After LVAD Implantation Is the Strongest Predictor of 30-Day Post-Operative Mortality

Author

Galand, Vincent, primary, Flécher, Erwan, additional, Auffret, Vincent, additional, Pichard, Camille, additional, Boulé, Stéphane, additional, Vincentelli, André, additional, Rollin, Anne, additional, Mondoly, Pierre, additional, Barandon, Laurent, additional, Pernot, Mathieu, additional, Kindo, Michel, additional, Cardi, Thomas, additional, Gaudard, Philippe, additional, Rouvière, Philippe, additional, Sénage, Thomas, additional, Jacob, Nicolas, additional, Defaye, Pascal, additional, Chavanon, Olivier, additional, Verdonk, Constance, additional, Ghodbane, Walid, additional, Pelcé, Edeline, additional, Gariboldi, Vlad, additional, Pozzi, Matteo, additional, Obadia, Jean-François, additional, Savouré, Arnaud, additional, Anselme, Frédéric, additional, Babatasi, Gerard, additional, Belin, Annette, additional, Garnier, Fabien, additional, Bielefeld, Marie, additional, Hamon, David, additional, Lellouche, Nicolas, additional, Pierre, Bertrand, additional, Bourguignon, Thierry, additional, Eschalier, Romain, additional, D’Ostrevy, Nicolas, additional, Bories, Marie-Cécile, additional, Marijon, Eloi, additional, Vanhuyse, Fabrice, additional, Blangy, Hugues, additional, Verhoye, Jean-Philippe, additional, Leclercq, Christophe, additional, and Martins, Raphaël P., additional

Published
2019
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29. Metagenomic Analysis of Microdissected Valvular Tissue for Etiological Diagnosis of Blood Culture–Negative Endocarditis

Author

Million, Matthieu, primary, Gaudin, Maxime, primary, Melenotte, Cléa, primary, Chasson, Lionel, primary, Edouard, Sophie, primary, Verdonk, Constance, primary, Prudent, Elsa, primary, Amphoux, Bernard, primary, Meresse, Stéphane, primary, Dorent, Richard, primary, Lepidi, Hubert, primary, La Scola, Bernard, primary, Gorvel, Jean-Pierre, primary, Desnues, Christelle, primary, and Raoult, Didier, primary

Published
2019
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31. Metagenomic Analysis of Microdissected Valvular Tissue for Etiological Diagnosis of Blood Culture–Negative Endocarditis.

Author

Million, Matthieu, Gaudin, Maxime, Melenotte, Cléa, Chasson, Lionel, Edouard, Sophie, Verdonk, Constance, Prudent, Elsa, Amphoux, Bernard, Meresse, Stéphane, Dorent, Richard, Lepidi, Hubert, Scola, Bernard La, Gorvel, Jean-Pierre, Desnues, Christelle, and Raoult, Didier

Subjects
DIAGNOSIS of endocarditis, COLLECTION & preservation of biological specimens, BLOOD, CELL culture, DNA, FLUORESCENT antibody technique, GENOMES, POLYMERASE chain reaction, RNA, WESTERN immunoblotting, GRAM-negative aerobic bacteria, SEQUENCE analysis
Abstract

Background Etiological diagnosis is a key to therapeutic adaptation and improved prognosis, particularly for infections such as endocarditis. In blood culture–negative endocarditis (BCNE), 22% of cases remain undiagnosed despite an updated comprehensive syndromic approach. This prompted us to develop a new diagnostic approach. Methods Eleven valves from 10 BCNE patients were analyzed using a method that combines human RNA bait-depletion with phi29 DNA polymerase-based multiple displacement amplification and shotgun DNA sequencing. An additional case in which a microbe was serendipitously visualized by immunofluorescence was analyzed using the same method, but after laser capture microdissection. Results Background DNA prevented any diagnosis in cases analyzed without microdissection because the majority of sequences were contaminants. Moraxella sequences were dramatically enriched in the stained microdissected region of the additional case. A consensus genome sequence of 2.4 Mbp covering more than 94% of the Moraxella osloensis KSH reference genome was reconstructed with 234X average coverage. Several antibiotic-resistance genes were observed. Etiological diagnosis was confirmed using Western blot and specific polymerase chain reaction with sequencing on a different valve sample. Conclusions Microdissection could be a key to the metagenomic diagnosis of infectious diseases when a microbe is visualized but remains unidentified despite an updated optimal approach. Moraxella osloensis should be tested in blood culture–negative endocarditis. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study

Author

Kerneis, Caroline, primary, Pasi, Nicoletta, additional, Arangalage, Dimitri, additional, Nguyen, Virginia, additional, Mathieu, Tiffany, additional, Verdonk, Constance, additional, Codogno, Isabelle, additional, Ou, Phalla, additional, Duval, Xavier, additional, Tubiana, Sarah, additional, Cimadevilla, Claire, additional, Vahanian, Alec, additional, and Messika-Zeitoun, David, additional

Published
2017
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34. Prognostic Value of Combination of Hemodynamic Parameters in Asymptomatic Aortic Valve Stenosis—The COFRASA/GENERAC Study

Author

Mathieu, Tiffany, primary, Nguyen, Virginia, additional, Cimadevilla, Claire, additional, Melissopoulou, Maria, additional, Codogno, Isabelle, additional, Verdonk, Constance, additional, Duval, Xavier, additional, Tubiana, Sarah, additional, Arangalage, Dimitri, additional, Vahanian, Alec, additional, and Messika-Zeitoun, David, additional

Published
2017
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35. Suprasternal brachiocephalic approach as an alternative route for transcatheter aortic valve implantation: a single-centre experience

Author

Capretti, Giuliana, primary, Urena, Marina, additional, Himbert, Dominique, additional, Ghodbane, Walid, additional, Gardy Verdonk, Constance, additional, Goublaire, Coppelia, additional, Alkhoder, Soleiman, additional, Raffoul, Richard, additional, Carrasco, Jose, additional, Laredo, Mikael, additional, Nataf, Patrick, additional, and Vahanian, Alec, additional

Published
2017
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36. Valve Thrombosis After Transcatheter Mitral Valve Replacement

Author

Capretti, Giuliana, primary, Urena, Marina, additional, Himbert, Dominique, additional, Brochet, Eric, additional, Goublaire, Coppelia, additional, Verdonk, Constance, additional, Carrasco, Jose Luis, additional, Ghodbane, Walid, additional, Messika-Zeitoun, David, additional, Iung, Bernard, additional, Nataf, Patrick, additional, and Vahanian, Alec, additional

Published
2016
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38. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study.

Author

Kerneis, Caroline, Pasi, Nicoletta, Arangalage, Dimitri, Nguyen, Virginia, Mathieu, Tiffany, Verdonk, Constance, Codogno, Isabelle, Ou, Phalla, Duval, Xavier, Tubiana, Sarah, Cimadevilla, Claire, Vahanian, Alec, and Messika-Zeitoun, David

Subjects
AGE distribution, AORTA, AORTIC aneurysms, AORTIC stenosis, VASODILATION, COMPUTED tomography, ECHOCARDIOGRAPHY, LONGITUDINAL method, MITRAL valve, SEX distribution, TRICUSPID valve, SEVERITY of illness index, BODY surface area, SINUS of valsalva
Abstract

Background Ascending aorta (AA) dilatation is common in aortic valve stenosis (AS) but data regarding AA progression, its determinants and impact of valve anatomy [bicuspid (BAV), or tricuspid (TAV)] are scarce. Methods and Results Asymptomatic AS patients enrolled in a prospective cohort (COFRASA/GENERAC) with at least 2 years of follow-up were considered in the present analysis. A transthoracic echocardiography (TTE) and a computed tomography (CT) scan were performed at inclusion and yearly thereafter. We enrolled 195 patients [mean gradient 22 ± 11 mmHg, 42 BAV patients (22%)]. Mean aorta diameters assessed using TTE were 35 ± 4 and 36 ± 5mm at the sinuses of Valsalva and tubular level, respectively. Ascending aorta diameter was >40mm in 29% of patients (24% in TAV vs. 52% in BAV, P < 0.01). Determinants of AA diameters were age, sex, BSA, and BAV, but not AS severity. After a mean follow-up of 3.8 ± 1.5years, AA enlargement rate assessed using TTE was þ0.18 ± 0.34 mm/ year and þ0.36 ± 0.54 mm/year at the Valsalva and tubular level, respectively. Determinants of the progression of AA size were smaller AA diameter (P < 0.01) but not baseline AS severity or valve anatomy (all P > 0.05). Only four patients presented an AA progression ≥ 2 mm/year. Correlations between TTE and CT scan were excellent (all r >0.74) and similar results were obtained using CT. During follow-up, two BAV patients underwent a combined AA surgery; no surgery was primarily performed for AA aneurysm and no dissection was observed. Conclusion In this prospective cohort of AS patients determinants of AA diameters were age, sex, BSA, and valve anatomy but not AS severity. AA progression rates were low and not influenced by AS severity or valve anatomy. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Characteristics and outcome of ambulatory heart failure patients receiving a left ventricular assist device.

Author

Baudry G, Nesseler N, Flecher E, Vincentelli A, Goeminne C, Delmas C, Porterie J, Nubret K, Pernot M, Kindo M, Hoang Minh T, Rouvière P, Gaudard P, Michel M, Senage T, Boignard A, Chavanon O, Para M, Verdonk C, Pelcé E, Gariboldi V, Anselme F, Litzler PY, Blanchart K, Babatasi G, Bielefeld M, Bouchot O, Hamon D, Lellouche N, Bailleul X, Genet T, Eschalier R, d'Ostrevy N, Bories MC, Akar RA, Blangy H, Vanhuyse F, Obadia JF, Galand V, and Pozzi M

Subjects
Aged, Humans, Male, Middle Aged, Registries, Survival Rate, Treatment Outcome, Heart Failure complications, Heart Failure therapy, Heart-Assist Devices
Abstract

Aims: Despite regularly updated guidelines, there is still a delay in referral of advanced heart failure patients to mechanical circulatory support and transplant centres. We aimed to analyse characteristics and outcome of non-inotrope-dependent patients implanted with a left ventricular assist device (LVAD)., Methods and Results: The ASSIST-ICD registry collected LVAD data in 19 centres in France between February 2006 and December 2016. We used data of patients in Interagency Registry for Mechanically Assisted Circulatory Support Classes 4-7. The primary endpoint was survival analysis. Predictors of mortality were searched with multivariable analyses. A total of 303 patients (mean age 61.0 ± 9.9 years, male sex 86.8%) were included in the present analysis. Ischaemic cardiomyopathy was the leading heart failure aetiology (64%), and bridge to transplantation was the main implantation strategy (56.1%). The overall likelihood of being alive while on LVAD support or having a transplant at 1, 2, 3, and 5 years was 66%, 61.7%, 58.7%, and 55.1%, respectively. Age [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.00-1.05; P = 0.02], a concomitant procedure (HR 2.32, 95% CI 1.52-3.53; P < 0.0001), and temporary mechanical right ventricular support during LVAD implantation (HR 2.94, 95% CI 1.49-5.77; P = 0.002) were the only independent variables associated with mortality. Heart failure medications before or after LVAD implantation were not associated with survival., Conclusion: Ambulatory heart failure patients displayed unsatisfactory survival rates after LVAD implantation. A better selection of patients who can benefit from LVAD may help improving outcomes., (© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2021
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41. Ascending aorta dilatation rates in patients with tricuspid and bicuspid aortic stenosis: the COFRASA/GENERAC study.

Author

Kerneis C, Pasi N, Arangalage D, Nguyen V, Mathieu T, Verdonk C, Codogno I, Ou P, Duval X, Tubiana S, Cimadevilla C, Vahanian A, and Messika-Zeitoun D

Subjects
Age Factors, Aged, Aged, 80 and over, Aorta diagnostic imaging, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis pathology, Cohort Studies, Disease Progression, Female, Humans, Male, Mitral Valve diagnostic imaging, Mitral Valve pathology, Prognosis, Prospective Studies, Risk Assessment, Sensitivity and Specificity, Sex Factors, Tricuspid Valve diagnostic imaging, Tricuspid Valve pathology, Aorta pathology, Aortic Valve Stenosis diagnostic imaging, Asymptomatic Diseases epidemiology, Echocardiography methods, Tomography, X-Ray Computed methods
Abstract

Background: Ascending aorta (AA) dilatation is common in aortic valve stenosis (AS) but data regarding AA progression, its determinants and impact of valve anatomy [bicuspid (BAV), or tricuspid (TAV)] are scarce., Methods and Results: Asymptomatic AS patients enrolled in a prospective cohort (COFRASA/GENERAC) with at least 2 years of follow-up were considered in the present analysis. A transthoracic echocardiography (TTE) and a computed tomography (CT) scan were performed at inclusion and yearly thereafter. We enrolled 195 patients [mean gradient 22 ± 11 mmHg, 42 BAV patients (22%)]. Mean aorta diameters assessed using TTE were 35 ± 4 and 36 ± 5 mm at the sinuses of Valsalva and tubular level, respectively. Ascending aorta diameter was >40 mm in 29% of patients (24% in TAV vs. 52% in BAV, P < 0.01). Determinants of AA diameters were age, sex, BSA, and BAV, but not AS severity. After a mean follow-up of 3.8 ± 1.5years, AA enlargement rate assessed using TTE was +0.18 ± 0.34 mm/year and +0.36 ± 0.54 mm/year at the Valsalva and tubular level, respectively. Determinants of the progression of AA size were smaller AA diameter (P < 0.01) but not baseline AS severity or valve anatomy (all P > 0.05). Only four patients presented an AA progression ≥2 mm/year. Correlations between TTE and CT scan were excellent (all r >0.74) and similar results were obtained using CT. During follow-up, two BAV patients underwent a combined AA surgery; no surgery was primarily performed for AA aneurysm and no dissection was observed., Conclusion: In this prospective cohort of AS patients determinants of AA diameters were age, sex, BSA, and valve anatomy but not AS severity. AA progression rates were low and not influenced by AS severity or valve anatomy.

Published
2018
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42. 3-D transoesophageal echocardiography guidance in percutaneous closure of three distant atrial septal defects.

Author

Aubry P, Brochet E, Verdonk C, Dilly MP, and Juliard JM

Subjects
Aged, Cardiac Catheterization instrumentation, Female, Follow-Up Studies, Heart Septal Defects, Atrial physiopathology, Humans, Minimally Invasive Surgical Procedures methods, Risk Assessment, Septal Occluder Device, Severity of Illness Index, Treatment Outcome, Cardiac Catheterization methods, Echocardiography, Three-Dimensional methods, Echocardiography, Transesophageal methods, Heart Septal Defects, Atrial diagnostic imaging, Heart Septal Defects, Atrial surgery
Published
2015
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