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13. Abstracts of Dutch doctoral theses

Author

Navis, G. J., Sterk, G. J., van Nispen, J. W., Hichens, M., Sauter, A., Lingeman, H., van den Beld, C. M. B., Tjaden, U. R., van der Greef, J., Desiderio, D. M., Cubbins, D. C., McMartin, C., Webb, R. L., Wennogle, L. P., Wysowskyi, H. E., Zimmerman, M. B., Lee, V. H. L., Sandow, J., Seidel, H., Schmiedel, R., Keller, Bradley T., Smith, Kevin R., Borchardt, Ronald T., Banks, W. A., Kastin, A. J., de Wied, D., DeLuca, P. P., Robinson, J. R., Lundin, S., Vilhardt, H., Saffran, M., Kumar, G. S., Neckers, D. G., Williams, F., Field, J. B., Jones, R. H., Panepinto, L., Harris, A. S., Moses, Alan C., Muranishi, S., Boddé, H. E., Ponec, M., Verhoef, J., Liversidge, Gary G., Boer, G. J., Kruisbrink, J., de Nijs, H., Bouwman, T. R. M., Eenink, M. J. D., Patel, Harish M., Bundgaard, H., Larsen, J. D., Nielsen, M. N., Buur, A., Tjadeh, U. R., Lemaire, M., Andres, H., Marbach, P., Widlund, L., Guilbaud, O., Wilton, P., van Bree, J. B. M. M., Audus, K. L., Deinum, Johanna, Norén, Karin, Sohtell, Morgan, Weström, B. R., Folkesson, H. G., Karlsson, B. W., Damge, C., Michel, C., Aprahamian, M., Couvreur, P., Puisieux, F., Touitou, E., Alhaique, F., Fisher, P., Memoli, A., Riccieri, F. M., Santucci, E., Hermens, W. A. J. J., Romei jn, S. G., Merkus, F. W. H. H., Schneider, C., Smith, T. W., Bremecker, K. -D., Hungerer, K. -D., Tabata, Y., Ikada, Y., Uno, K., Muramatsu, S., Bruning, J. W., Claas, F. H. J., Kardol, M. J., van Ree, J. M., Rust, C. J. J., Verduyn, W., Wiegant, V. M., Wolterink, G., van Hoogdalem, E. J., Heijligers-Feijen, C. D., de Boer, A. G., Breimer, D. D., Lambalk, C. B., van Kessel, H., de Koning, J., van Dieten, J. A. M. J., van Rees, G. P., Schoemaker, J., Devissaguet J. -Ph., Orieu K., Dray F., Ezan E., Devissaguet J. Ph., Drieu K., Dray P., Ezah E., Barnfield, D. J., Barker, Y. K., Knott, S., Miles, G. S., Warrander, A., Adam, H. K., Barker, Y., Hutchinson, F. G., Milsted, R. A. V., Moore, R. H., Swaisland, A. J., Barke, Y., Porter, E. T., Holmes, B., Barnard, M., Beijnen, J. H., Lubbers, S. C. H., van der Houwen, O. A. G. J., Lobbezoo, M. W., Underberg, W. J. M., Cachet, Th., Roets, E., Hoogmartens, J., Vanderhaeghe, H., de Bree, H., van der Stel, D. J. K., Brockhoff, O. A. M., van Berkel, M. P., Sierat, K., de Groot, G., Tepas, B. C. A., de Noord, O. E., Hempenius, J., Coenegracht, P. M. J., Jonkman, J. H. G., Doornbos, D. A., De Schutter, J. A., De Moerloose, P., Delbressine, L. P. C., Kaspersen, F. M., Blokland, A., Duchateau, A. L. L., Verstappen, T. A., Hendricks, P. J. H., Elferink, F, Leeuwenkamp, O R, Pinedo, H M, vd Vijgh, W J F, Ensing, K., Bloemhof, D. A., In 't Hout, W. G., de Zeeuw, R. A., Feitsma, Karla G., Drenth, Ben F. H., de Zeeuw, Rokus A., Gerding, T. K., Drenth, B. F. H., Horn, A. S., Groen, C. P., Tipker, J., van den Bergh-Swart, J. K., Spruit, F. J., van den Berg, J. H. M., Bramel, E. H. Groot, Bekers, O., Otagiri, M., Janssen, P. S. L., Nispen, J. W. v., Melgers, P. A. T. A., Zeeland, M. J. M. v., Hamelinck, R. L. A. E., Goverde, B. C., Aalst, G. W. M. v., Kootstra, P. R., van den Broek, H. H., Hogendoorn, E. A., Goewie, C. E., Kwakman, P. J. M., Brinkman, U. A. Th., Frei, R. W., de Jong, G. J., Lammers, N. G. F. M., Lammers, N., Ruijten, H. M., de Jong, J., Maessen, P. A., Mross, K. B., Plnedo, H. M., van der Vljgh, W. J. F., Khan, Naeem Hasan, Hoogmartens, J., Rose, S. V., van Bueren, L. G. D. Lammerts, van Amsterdam, P. H., van Beek, H., Baars, A. J., van Ginkel, L. A., Steinbuch, H. M., van Rossum, H. J., van Blitterswijk, H., Zoontjes, P. W., Heeft, E. v. d., de Jong, A. J. P. M., Stephany, R. W., van Gijn, R., de Clippeleir, J. J. M., Verweij, S. L., Paalman, A. C. A., van Opstal, M. A. J., Krabbenborg, P., Holthuis, J. J. M., van Bennekom, W. P., Bult, A., Redegeld, F. A. M., Houdkamp, E., van de Water, C., Haagsma, N., van der Stel, D. J. K., Vendrig, D. E. M. M., Mekking, A., and Teeuwsen, J.

Published
1988
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14. Abstracts of posters symposium disposition and delivery of peptide drugs

Author

Bundgaard, H., Larsen, J. D., Nielsen, M. N., Buur, A., Lingeman, H., Tjadeh, U. R., van den Beld, C. M. B., van der Greef, J., Lemaire, M., Andres, H., Marbach, P., Widlund, L., Guilbaud, O., Wilton, P., van Bree, J. B. M. M., Audus, K. L., Deinum, Johanna, Norén, Karin, Sohtell, Morgan, Weström, B. R., Folkesson, H. G., Lundin, S., Karlsson, B. W., E. Touitou, Alhalque, F., Fisher, P., Memoli, A., Ricciari, F. M., Santucci, E., Hermens, W. A. J. J., Romeijn, S. G., Merkus, F. W. H. M., Schneider, C., Smith, T. W., Bremecker, K. -D., Hungerer, K. -D., Tabata, Y., Ikada, Y., Uno, K., Muramatsu, S., Bruning, J. W., Class, F. J. J., Kardol, M. J., van Ree, J. H., Rust, C. J. J., Verduyn, W., Wiagant, V. M., Wolterink, G., van Hoogdalem, E. J., Heijligers-Feijen, C. D., Verhoef, J., de Boer, A. D., Breimer, D. D., Lambalk, C. B., van Kessel, H., de Koning, J., van Dieten, J. A. M. J., van Rees, G. P., Schoemaker, J., Devissaguet, J -Ph., Drieu, K., Dray, F., Ezan, E., Barnfield, D. J., Barker, Y. K., Knott, S., Miles, G. S., Warrander, A., Adam, H. K., Barker, Y., Hutchinson, F. G., Milsted, R. A. V., Moore, R. H., Swaisland, A. J., Holmes, B., Moore, R. H., Barker, Y., and Porter, E. T.

Published
1988
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15. The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases

Author

Kurreeman, F.A.S., Goulielmos, G.N., Alizadeh, B.Z., Rueda, B., Houwing-Duistermaat, J., Sanchez, E., Bevova, M., Radstake, T.R., Vonk, M.C., Galanakis, E., Ortego, N., Verduyn, W., Zervou, M.I., Roep, B.O., Dema, B., Espino, L., Urcelay, E., Boumpas, D.T., Van Den Berg, L.H., Wijmenga, C., Koeleman, B.P.C., Huizinga, T.W.J., Toes, R.E.M., Martin, J., Jiménez-Alonso, J., Sanchez-Román, J., De-Ramon, E., Camps, M., Aguirre, M.A., García-Portales, R., Harley, J.B., Criswell, L.A., Vyse, T., Kimberly, R., Jacob, C., Moser, K., Langfeldt, C., Alarcón-Riquelme, M.E., and Tsao, B.

Subjects
medicine.medical_specialty, Genotype, Immunology, Genome-wide association study, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Auto-immunity, transplantation and immunotherapy [N4i 4], General Biochemistry, Genetics and Molecular Biology, Autoimmune Diseases, Rheumatology, immune system diseases, Internal medicine, Immunopathology, medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, Allele, skin and connective tissue diseases, Autoimmune disease, Scleroderma, Systemic, systemic-lupus-erythematosus genome-wide association juvenile idiopathic arthritis rheumatoid-arthritis susceptibility risk polymorphism variants locus populations, business.industry, medicine.disease, Connective tissue disease, TNF Receptor-Associated Factor 1, Celiac Disease, Diabetes Mellitus, Type 1, Rheumatoid arthritis, business, Chromosomes, Human, Pair 9, Infection and autoimmunity [NCMLS 1]
Abstract

Item does not contain fulltext OBJECTIVES: The TRAF1-C5 locus has recently been identified as a genetic risk factor for rheumatoid arthritis (RA). Since genetic risk factors tend to overlap with several autoimmune diseases, a study was undertaken to investigate whether this region is associated with type 1 diabetes (TID), celiac disease (CD), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). METHODS: The most consistently associated SNP, rs10818488, was genotyped in a total of 735 patients with T1D, 1049 with CD, 367 with SSc, 746 with SLE and 3494 ethnically- and geographically-matched healthy individuals. The replication sample set consisted of 99 patients with T1D, 272 with SLE and 482 healthy individuals from Crete. RESULTS: A significant association was detected between the rs10818488 A allele and T1D (OR 1.14, p=0.027) and SLE (OR 1.16, p=0.016), which was replicated in 99 patients with T1D, 272 with SLE and 482 controls from Crete (OR 1.64, p=0.002; OR 1.43, p=0.002, respectively). Joint analysis of all patients with T1D (N=961) and all patients with SLE (N=1018) compared with 3976 healthy individuals yielded an allelic common OR of 1.19 (p=0.002) and 1.22 (p=2.6 x 10(-4)), respectively. However, combining our dataset with the T1D sample set from the WTCCC resulted in a non-significant association (OR 1.06, p=0.087). In contrast, previously unpublished results from the SLEGEN study showed a significant association of the same allele (OR 1.19, p=0.0038) with an overall effect of 1.22 (p=1.02 x 10(-6)) in a total of 1577 patients with SLE and 4215 healthy individuals. CONCLUSION: A significant association was found for the TRAF1-C5 locus in SLE, implying that this region lies in a pathway relevant to multiple autoimmune diseases. 01 april 2010

Published
2010

17. FRI0341 Anti-Carp Antibodies in Two Large Cohorts of Patients with Rheumatoid Arthritis and their Relationship to Genetic Risk Factors, Cigarette Smoking and Other Autoantibodies

Author

Jiang, X., primary, Trouw, L., additional, van Wesemael, T., additional, Shi, J., additional, Bengtsson, C., additional, Kallberg, H., additional, Malmstrom, V., additional, Israelsson, L., additional, Hreggvidsdottir, H., additional, Verduyn, W., additional, Klareskog, L., additional, Alfredsson, L., additional, Huizinga, T., additional, Toes, R., additional, Lundberg, K., additional, and Van Der Woude, D., additional

Published
2014
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18. Relation between HLA genes, human skin volatiles and attractiveness of humans to malaria mosquitoes

Author

Verhulst, N.O., Beijleveld, H., Qiu, Y.T., Maliepaard, C.A., Verduyn, W., Haasnoot, G.W., Claas, F.H.J., Mumm, R., Bouwmeester, H.J., Takken, W., van Loon, J.J.A., Smallegange, R.C., Verhulst, N.O., Beijleveld, H., Qiu, Y.T., Maliepaard, C.A., Verduyn, W., Haasnoot, G.W., Claas, F.H.J., Mumm, R., Bouwmeester, H.J., Takken, W., van Loon, J.J.A., and Smallegange, R.C.

Abstract

Chemical cues are considered to be the most important cues for mosquitoes to find their hosts and humans can be ranked for attractiveness to mosquitoes based on the chemical cues they emit. Human leukocyte antigen (HLA) genes are considered to be involved in the regulation of human body odor and may therefore affect human attractiveness to mosquitoes, and hence, affect the force of malaria transmission. In the present study the correlations between HLA profiles, human skin volatiles and human attractiveness to the malaria mosquito Anopheles gambiae Giles sensu stricto were examined. Skin emanations of 48 volunteers were collected by rubbing a foot over glass beads. Previously the attractiveness of these emanations to An. gambiae was determined. In this study, the chemical composition of these emanations was determined by gas chromatography–mass spectroscopy (GC–MS) and blood samples of all volunteers were taken for HLA analysis. Hierarchical cluster analysis (HCA), partial least squares discriminant analysis (PLS-DA), Fisher’s exact test and random forest regression were used to test for correlations between individuals classified as either highly or poorly attractive to mosquitoes and their HLA profile and volatile composition. HLA profiling suggests that people carrying HLA gene Cw*07 are more attractive to mosquitoes. GC–MS revealed that limonene, 2-phenylethanol and 2-ethyl-1-hexanol were associated with individuals that were poorly attractive to An.gambiae and lactic acid, 2-methylbutanoic acid, tetradecanoic acid and octanal with individuals that were highly attractive. Such compounds offer potential for disruption of mosquito behavior in malaria intervention programs.

Published
2013

20. The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases.

Author

Kurreeman, F.A., Goulielmos, G.N., Alizadeh, B.Z., Rueda, B., Houwing-Duistermaat, J., Sanchez, E., Bevova, M., Radstake, T.R.D.J., Vonk, M.C., Galanakis, E., Ortego, N., Verduyn, W., Zervou, M.I., Roep, B.O., Dema, B., Espino, L., Urcelay, E., Boumpas, D.T., Berg, L.H. van den, Wijmenga, C., Koeleman, B.P., Huizinga, T.W.J., Toes, R.E., Martin, J., Kurreeman, F.A., Goulielmos, G.N., Alizadeh, B.Z., Rueda, B., Houwing-Duistermaat, J., Sanchez, E., Bevova, M., Radstake, T.R.D.J., Vonk, M.C., Galanakis, E., Ortego, N., Verduyn, W., Zervou, M.I., Roep, B.O., Dema, B., Espino, L., Urcelay, E., Boumpas, D.T., Berg, L.H. van den, Wijmenga, C., Koeleman, B.P., Huizinga, T.W.J., Toes, R.E., and Martin, J.

Abstract

1 april 2010, Item does not contain fulltext, OBJECTIVES: The TRAF1-C5 locus has recently been identified as a genetic risk factor for rheumatoid arthritis (RA). Since genetic risk factors tend to overlap with several autoimmune diseases, a study was undertaken to investigate whether this region is associated with type 1 diabetes (TID), celiac disease (CD), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). METHODS: The most consistently associated SNP, rs10818488, was genotyped in a total of 735 patients with T1D, 1049 with CD, 367 with SSc, 746 with SLE and 3494 ethnically- and geographically-matched healthy individuals. The replication sample set consisted of 99 patients with T1D, 272 with SLE and 482 healthy individuals from Crete. RESULTS: A significant association was detected between the rs10818488 A allele and T1D (OR 1.14, p=0.027) and SLE (OR 1.16, p=0.016), which was replicated in 99 patients with T1D, 272 with SLE and 482 controls from Crete (OR 1.64, p=0.002; OR 1.43, p=0.002, respectively). Joint analysis of all patients with T1D (N=961) and all patients with SLE (N=1018) compared with 3976 healthy individuals yielded an allelic common OR of 1.19 (p=0.002) and 1.22 (p=2.6 x 10(-4)), respectively. However, combining our dataset with the T1D sample set from the WTCCC resulted in a non-significant association (OR 1.06, p=0.087). In contrast, previously unpublished results from the SLEGEN study showed a significant association of the same allele (OR 1.19, p=0.0038) with an overall effect of 1.22 (p=1.02 x 10(-6)) in a total of 1577 patients with SLE and 4215 healthy individuals. CONCLUSION: A significant association was found for the TRAF1-C5 locus in SLE, implying that this region lies in a pathway relevant to multiple autoimmune diseases.

Published
2010

23. The interaction between HLA SE alleles and smoking and its contribution to autoimmunity against several citrullinated antigens

Author

Willemze, A., primary, van der Woude, D., additional, Alemayehu, W. G., additional, Levarht, E. W. N., additional, Stoeken-Rijsbergen, G., additional, Verduyn, W., additional, de Vries, R. R. P., additional, Houwing, J., additional, Huizinga, T. W. J., additional, Trouw, L. A., additional, and Toes, R. E. M., additional

Published
2011
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38. TNF-308A and HLA–DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus

Author

Rood, M. J., Krugten, M. V. Van, Zanelli, E., Linden, M. W. Van Der, Keijsers, V., Schreuder, G. M. T., Verduyn, W., Westendorp, R. G. J., Vries, R. R. P. De, Breedveld, F. C., Verweij, C. L., and Huizinga, T. W. J.

Abstract

To evaluate the respective contributions of tumor necrosis factor (TNF) promoter polymorphisms and HLA–DR alleles to susceptibility to systemic lupus erythematosus (SLE). TNF-238G/A and 308G/A promoter polymorphisms and HLA–DRB1 alleles were determined in 99 consecutive Caucasian SLE patients and 177 Caucasian controls. Standard and Mantel-Haenszel odds ratios were calculated to assess the magnitude of the susceptibility factors. The presence or absence of the SLE classification criteria was determined and correlated with the TNF promoter and HLA–DRB1 genotypes. The frequency of the TNF-308A/A and 308G/A genotypes was significantly higher in SLE patients (odds ratio 5.0). Conversely, TNF-238G/A and 238A/A genotypes were equally prevalent in SLE patients and controls. The HLA–DR3 specificity (DRB1*0301 allele) was significantly more prevalent in the SLE population (odds ratio 4.4). Stratification to correct for interdependence of the 2 loci confirmed the association of both TNF-308A and HLA–DR3 with SLE (Mantel-Haenszel odds ratio 3.2 and 2.4, respectively). No correlation was found between TNF promoter and HLA–DRB1 genotypes and any SLE classification criterion or disease manifestation. TNF-308A and HLA–DR3 alleles are independent susceptibility factors for SLE.

Published
2000
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