Search

Your search keyword '"Verga, Julia A."' showing total 11 results
Start Over Author "Verga, Julia A."
11 results on '"Verga, Julia A."'

2. Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations

Author

Miller, Tyler E., Lareau, Caleb A., Verga, Julia A., DePasquale, Erica A. K., Liu, Vincent, Ssozi, Daniel, Sandor, Katalin, Yin, Yajie, Ludwig, Leif S., El Farran, Chadi A., Morgan, Duncan M., Satpathy, Ansuman T., Griffin, Gabriel K., Lane, Andrew A., Love, J. Christopher, Bernstein, Bradley E., Sankaran, Vijay G., and van Galen, Peter

Published
2022
Full Text
View/download PDF

3. Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Author

van Galen, Peter, Hovestadt, Volker, Wadsworth II, Marc H., Hughes, Travis K., Griffin, Gabriel K., Battaglia, Sofia, Verga, Julia A., Stephansky, Jason, Pastika, Timothy J., Lombardi Story, Jennifer, Pinkus, Geraldine S., Pozdnyakova, Olga, Galinsky, Ilene, Stone, Richard M., Graubert, Timothy A., Shalek, Alex K., Aster, Jon C., Lane, Andrew A., and Bernstein, Bradley E.

Published
2019
Full Text
View/download PDF

4. Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas

Author

Miller, Tyler E, primary, El Farran, Chadi Abdul Kader, additional, Couturier, Charles P, additional, Chen, Zeyu, additional, D'Antonio, Joshua P, additional, Verga, Julia, additional, Villanueva, Martin A, additional, Castro, L. Nicolas Gonzalez, additional, Tong, Yuzhou Evelyn, additional, Al-Saadi, Tariq, additional, Chiocca, Andrew N, additional, Fischer, David S, additional, Heiland, Dieter Henrik, additional, Guerriero, Jennifer L, additional, Petrecca, Kevin, additional, Suva, Mario L, additional, Shalek, Alex K, additional, and Bernstein, Bradley E, additional

Published
2023
Full Text
View/download PDF

5. Clonal Hematopoiesis Evolves into Dendritic Cell Neoplasm through the Acquisition of UV Mutations in the Skin

Author

Van Galen, Peter, primary, Griffin, Gabriel K., additional, Booth, Christopher A.G., additional, Togami, Katsuhiro, additional, Chung, Sun Sook, additional, Ssozi, Daniel, additional, Verga, Julia A., additional, Bouyssou, Juliette M.C., additional, Lee, Yoke Seng, additional, Shanmugam, Vignesh, additional, LeBoeuf, Nicole R., additional, Morgan, Elizabeth A., additional, Bernstein, Bradley E., additional, Hovestadt, Volker, additional, and Lane, Andrew A., additional

Published
2022
Full Text
View/download PDF

8. Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Author

Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research at MIT, van Galen, Peter, Hovestadt, Volker, Wadsworth II, Marc H., Hughes, Travis K., Griffin, Gabriel K., Battaglia, Sofia, Verga, Julia A., Stephansky, Jason, Pastika, Timothy J., Lombardi Story, Jennifer, Pinkus, Geraldine S., Pozdnyakova, Olga, Galinsky, Ilene, Stone, Richard M., Graubert, Timothy A., Shalek, Alex K., Aster, Jon C., Lane, Andrew A., Bernstein, Bradley E., Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research at MIT, van Galen, Peter, Hovestadt, Volker, Wadsworth II, Marc H., Hughes, Travis K., Griffin, Gabriel K., Battaglia, Sofia, Verga, Julia A., Stephansky, Jason, Pastika, Timothy J., Lombardi Story, Jennifer, Pinkus, Geraldine S., Pozdnyakova, Olga, Galinsky, Ilene, Stone, Richard M., Graubert, Timothy A., Shalek, Alex K., Aster, Jon C., Lane, Andrew A., and Bernstein, Bradley E.

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex microenvironment, complicating efforts to understand how different cell types contribute to disease progression. We combined single-cell RNA sequencing and genotyping to profile 38,410 cells from 40 bone marrow aspirates, including 16 AML patients and five healthy donors. We then applied a machine learning classifier to distinguish a spectrum of malignant cell types whose abundances varied between patients and between subclones in the same tumor. Cell type compositions correlated with prototypic genetic lesions, including an association of FLT3-ITD with abundant progenitor-like cells. Primitive AML cells exhibited dysregulated transcriptional programs with co-expression of stemness and myeloid priming genes and had prognostic significance. Differentiated monocyte-like AML cells expressed diverse immunomodulatory genes and suppressed T cell activity in vitro. In conclusion, we provide single-cell technologies and an atlas of AML cell states, regulators, and markers with implications for precision medicine and immune therapies. Video Abstract: A combination of transcriptomics and mutational analyses in single cells from acute myeloid leukemia patients reveals the existence of distinct functional subsets and their associated drivers.

Published
2020

9. Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity

Author

Van Galen, Peter, primary, Hovestadt, Volker, additional, Wadsworth II, Marc, additional, Hughes, Travis, additional, Griffin, Gabriel Kenneth, additional, Verga, Julia A., additional, Stephansky, Jason, additional, Pastika, Timothy J., additional, Lombardi Story, Jennifer, additional, Pinkus, Geraldine S., additional, Pozdnyakova, Olga, additional, Galinsky, Ilene, additional, Stone, Richard M., additional, Graubert, Timothy A., additional, Shalek, Alex K., additional, Aster, Jon C., additional, Lane, Andrew A., additional, and Bernstein, Bradley E., additional

Published
2018
Full Text
View/download PDF

10. Single-Cell Analysis of AML Reveals Determinants of Disease Progression and Immune Evasion

Author

van Galen, Peter, primary, Hovestadt, Volker, additional, Griffin, Gabriel, additional, Verga, Julia, additional, Wadsworth, Marc, additional, Hughes, Travis, additional, Stephansky, Jason, additional, Pastika, TImothy, additional, Story, Jennifer Lombardi, additional, Pinkus, Geraldine, additional, Pozdnyakova, Olga, additional, Graubert, Timothy, additional, Shalek, Alex, additional, Aster, Jon, additional, Lane, Andrew, additional, and Bernstein, Bradley, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results