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2. A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery.

Author

Metere, Alessio, Frezzotti, Francesca, Graves, Claire Elizabeth, Vergine, Massimo, De Luca, Alessandro, Pietraforte, Donatella, and Giacomelli, Laura

Subjects
Glutathione peroxidase, Oxidative stress, Selenium enzymes, Thioredoxin reductases, Thyroid cancer, Biochemistry and Cell Biology, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxidative stress in thyroid cancer by analyzing the expression of two selenium antioxidant molecules, glutathione peroxidase (GPx1) and thioredoxin reductase (TrxR1) in thyroid cancer cells. Methods:Samples of both healthy thyroid tissue and thyroid tumor were taken for analysis after total thyroidectomy. The expression of GPx1 and TrxR1 was revealed by Western blot analysis and quantified by densitometric analyses, while the evaluation of free radicals was performed by Electron Paramagnetic Resonance (EPR)-spin trapping technique. Results:Our results show a decrease in the expression of GPx1 and TrxR1 (- 45.7 and - 43.2% respectively, p

Published
2018

3. Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results

Author

Elia, Daniela, Fresilli, Daniele, Pacini, Patrizia, Cardaccio, Sara, Polti, Giorgia, Guiban, Olga, Celletti, Ilaria, Kutrolli, Eriselda, De Felice, Carlo, Occhiato, Rossella, De Vito, Corrado, Amabile, Maria Ida, De Luca, Alessandro, D’Andrea, Vito, Vergine, Massimo, Pediconi, Federica, D’Ambrosio, Ferdinando, and Cantisani, Vito

Published
2021
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4. Thyroid diseases and skin autoimmunity

Author

Baldini, Enke, Odorisio, Teresa, Tuccilli, Chiara, Persechino, Severino, Sorrenti, Salvatore, Catania, Antonio, Pironi, Daniele, Carbotta, Giovanni, Giacomelli, Laura, Arcieri, Stefano, Vergine, Massimo, Monti, Massimo, and Ulisse, Salvatore

Published
2018
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5. Can New Ultrasound Imaging Techniques Improve Breast Lesion Characterization? Prospective Comparison between Ultrasound BI-RADS and Semi-Automatic Software “SmartBreast”, Strain Elastography, and Shear Wave Elastography

Author

Guiban, Olga, primary, Rubini, Antonello, additional, Vallone, Gianfranco, additional, Caiazzo, Corrado, additional, Di Serafino, Marco, additional, Pediconi, Federica, additional, Ballesio, Laura, additional, Trenta, Federica, additional, De Vito, Corrado, additional, Shkelqimi, Arenta, additional, Costanzo, Ludovica, additional, Fresilli, Daniele, additional, Rizzo, Veronica, additional, Cantisani, Vito, additional, and Vergine, Massimo, additional

Published
2023
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7. Oncofertility and Reproductive Counseling in Patients with Breast Cancer: A Retrospective Study

Author

Zaami, Simona, primary, Melcarne, Rossella, additional, Patrone, Renato, additional, Gullo, Giuseppe, additional, Negro, Francesca, additional, Napoletano, Gabriele, additional, Monti, Marco, additional, Aceti, Valerio, additional, Panarese, Alessandra, additional, Borcea, Maria Carola, additional, Scorziello, Chiara, additional, Ventrone, Luca, additional, Mamedov, Samira Nicole, additional, Meggiorini, Maria Letizia, additional, Vergine, Massimo, additional, and Giacomelli, Laura, additional

Published
2022
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8. Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer

Author

Tripodi, Domenico, primary, Cannistra’, Claudio, additional, Gagliardi, Federica, additional, Casella, Giovanni, additional, Lauro, Augusto, additional, De Luca, Alessandro, additional, Amabile, Maria Ida, additional, Palumbo, Piergaspare, additional, Pironi, Daniele, additional, Mascagni, Domenico, additional, D’Andrea, Vito, additional, Vergine, Massimo, additional, and Sorrenti, Salvatore, additional

Published
2021
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9. Expression and Clinical Utility of Transcription Factors Involved in Epithelial–Mesenchymal Transition during Thyroid Cancer Progression

Author

Baldini, Enke, primary, Tuccilli, Chiara, additional, Pironi, Daniele, additional, Catania, Antonio, additional, Tartaglia, Francesco, additional, Di Matteo, Filippo Maria, additional, Palumbo, Piergaspare, additional, Arcieri, Stefano, additional, Mascagni, Domenico, additional, Palazzini, Giorgio, additional, Tripodi, Domenico, additional, Maturo, Alessandro, additional, Vergine, Massimo, additional, Tarroni, Danilo, additional, Lori, Eleonora, additional, Ferent, Iulia Catalina, additional, De Vito, Corrado, additional, Fallahi, Poupak, additional, Antonelli, Alessandro, additional, Censi, Simona, additional, D’Armiento, Matteo, additional, Barollo, Susy, additional, Mian, Caterina, additional, Morrone, Aldo, additional, D’Andrea, Vito, additional, Sorrenti, Salvatore, additional, and Ulisse, Salvatore, additional

Published
2021
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10. Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy

Author

Amabile, Maria, primary, De Luca, Alessandro, additional, Tripodi, Domenico, additional, D’Alberti, Elena, additional, Melcarne, Rossella, additional, Imbimbo, Giovanni, additional, Picconi, Orietta, additional, D’Andrea, Vito, additional, Vergine, Massimo, additional, Sorrenti, Salvatore, additional, and Molfino, Alessio, additional

Published
2021
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11. Romidepsin (FK228) fails in counteracting the transformed phenotype of rhabdomyosarcoma cells but efficiently radiosensitizes, in vitro and in vivo, the alveolar phenotype subtype

Author

Rossetti, Alessandra, primary, Petragnano, Francesco, additional, Milazzo, Luisa, additional, Vulcano, Francesca, additional, Macioce, Giampiero, additional, Codenotti, Silvia, additional, Cassandri, Matteo, additional, Pomella, Silvia, additional, Cicchetti, Francesca, additional, Fasciani, Irene, additional, Antinozzi, Cristina, additional, Di Luigi, Luigi, additional, Festuccia, Claudio, additional, De Felice, Francesca, additional, Vergine, Massimo, additional, Fanzani, Alessandro, additional, Rota, Rossella, additional, Maggio, Roberto, additional, Polimeni, Antonella, additional, Tombolini, Vincenzo, additional, Gravina, Giovanni Luca, additional, and Marampon, Francesco, additional

Published
2021
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12. Retrospective Evaluation of the Effectiveness of a Synthetic Glue and a Fibrin-Based Sealant for the Prevention of Seroma Following Axillary Dissection in Breast Cancer Patients

Author

De Luca, Alessandro, primary, Tripodi, Domenico, additional, Frusone, Federico, additional, Leonardi, Beatrice, additional, Cerbelli, Bruna, additional, Botticelli, Andrea, additional, Vergine, Massimo, additional, D'Andrea, Vito, additional, Pironi, Daniele, additional, Sorrenti, Salvatore, additional, and Amabile, Maria Ida, additional

Published
2020
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13. Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results

Author

Elia, Daniela, primary, Fresilli, Daniele, additional, Pacini, Patrizia, additional, Cardaccio, Sara, additional, Polti, Giorgia, additional, Guiban, Olga, additional, Celletti, Ilaria, additional, Kutrolli, Eriselda, additional, De Felice, Carlo, additional, Occhiato, Rossella, additional, De Vito, Corrado, additional, Amabile, Maria Ida, additional, De Luca, Alessandro, additional, D’Andrea, Vito, additional, Vergine, Massimo, additional, Pediconi, Federica, additional, D’Ambrosio, Ferdinando, additional, and Cantisani, Vito, additional

Published
2020
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14. Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer

Author

Tuccilli, Chiara, Baldini, Enke, Arlot Bonnemains, Yannick, Chesnel, Frank, Sorrenti, Salvatore, De Vito, Corrado, D'Armiento, Eleonora, Antonelli, Alessandro, Fallahi, Poupak, Watutantrige, Sara, Tartaglia, Francesco, Barollo, Susi, Mian, Caterina, Arcieri, Stefano, Mascagni, Domenico, Pironi, Daniele, Bononi, Marco, Vergine, Massimo, Monti, Massimo, Filippini, Angelo, Ulisse, Salvatore, WATUTANTRIGE FERNANDO, Sara, Department of Experimental Medicine, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Surgical Sciences, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Internal Medicine, University of Pisa - Università di Pisa, Department of Medical and Surgical Sciences, Università degli Studi di Padova = University of Padua (Unipd), Sapienza University of Rome [C26A14RNFY, C26N145E4T], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universita degli Studi di Padova, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
0301 basic medicine, Cancer Research, medicine.medical_specialty, Cell, Anaplastic thyroid carcinoma, Apico-basal polarity, APKC, Papillary thyroid carcinoma, PAR complex, PARD3, PARD6, Thyroid, Biology, Apico-basal polarity, 03 medical and health sciences, Internal medicine, Cell polarity, Gene expression, medicine, Anaplastic thyroid carcinoma, APKC, Papillary thyroid carcinoma, PAR complex, PARD3, PARD6, Thyroid, Oncology, Thyroid cancer, [SDV.GEN]Life Sciences [q-bio]/Genetics, Oncogene, Cancer, Cell cycle, medicine.disease, Molecular medicine, 3. Good health, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Cancer research
Abstract

International audience; Establishment and maintenance of the apical basal cell polarity, required for proper replication, migration, specialized functions and tissue morphogenesis, relies on three evolutionary conserved complexes: PAR, CRUMBS and SCRIBBLE. Loss of cell polarity/cohesiveness (LOP/C) is implicated in cancer progression, and members of the polarity complex have been described as either oncogenes or oncosuppressors. However, no information on their role in thyroid cancer (TC) progression is available. In the present study, we evaluated the gene expression of the PAR complex members aPKCt, PARD3 alpha/beta and PARD6 alpha/beta/gamma in 95 papillary TC (PTC), compared to their normal matched tissues and in 12 anaplastic TC (ATC). The mRNA and protein levels of investigated genes were altered in the majority of PTC and ATC tissues. In PTC, univariate analysis showed that reduced expression of aPKCt, PARD3 beta and PARD6 gamma mRNAs is associated with increased tumor size, and the reduced expression of PARD3 beta mRNA is associated also with recurrences. Multivariate analysis demonstrated that the presence of lymph node metastasis at diagnosis and the reduced expression of PARD3 beta are independent risk factors for recurrences, with hazard ratio, respectively, of 8.21 (P=0.006) and 3.04 (P=0.029). The latter result was confirmed by the Kaplan-Meier analysis, which evidenced the association between decreased PARD3 beta mRNA levels and shorter disease-free interval. In conclusion, we demonstrated that the expression of PAR complex components is deregulated in the majority of PTC and there is a general trend towards their reduction in ATC tissues. Moreover, a prognostic value for the PARD3 beta gene in PTCs is suggested.

Published
2017

16. Nodular thyroid disease with aging

Author

Baldini, Enke, Sorrenti, Salvatore, Catania, Antonio, Tartaglia, Francesco, Pironi, Daniele, Vergine, Massimo, Monti, Massimo, Filippini, Angelo, and Ulisse, Salvatore

Subjects
Thyroid, Aging, Nodules, Diagnosis, Nodules, Thyroid, Aging, Diagnosis
Published
2018

17. PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

Author

Ulisse, Salvatore, primary, Tuccilli, Chiara, additional, Sorrenti, Salvatore, additional, Antonelli, Alessandro, additional, Fallahi, Poupak, additional, D’Armiento, Eleonora, additional, Catania, Antonio, additional, Tartaglia, Francesco, additional, Amabile, Maria, additional, Giacomelli, Laura, additional, Metere, Alessio, additional, Cornacchini, Nicola, additional, Pironi, Daniele, additional, Carbotta, Giovanni, additional, Vergine, Massimo, additional, Monti, Massimo, additional, and Baldini, Enke, additional

Published
2019
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21. Minilinfectomia radioguidata (SeRAD) nelle pazienti affetta da cancro della mammella cN0: proposta di tecnica e risultati preliminari

Author

Frusone, Federico, DE LUCA, Alessandro, Aceti, Valerio, Federica, Maceli, Federica, Lauria, Vergine, Massimo, Mannocci, Alice, LA TORRE, Giuseppe, and Monti, Massimo

Subjects
minilinfectomia radioguidata, breast cancer, breast cancer, breast surgery, axillary surgery, minilinfectomia radioguidata, SeRAD, SeRAD, breast surgery, axillary surgery
Published
2017

23. CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers

Author

Tuccilli, Chiara, primary, Baldini, Enke, additional, Sorrenti, Salvatore, additional, Catania, Antonio, additional, Antonelli, Alessandro, additional, Fallahi, Poupak, additional, Tartaglia, Francesco, additional, Barollo, Susi, additional, Mian, Caterina, additional, Palmieri, Andrea, additional, Carbotta, Giovanni, additional, Arcieri, Stefano, additional, Pironi, Daniele, additional, Vergine, Massimo, additional, Monti, Massimo, additional, and Ulisse, Salvatore, additional

Published
2018
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24. Deregulated expression of VHL mRNA variants in papillary thyroid cancer

Author

Baldini, Enke, primary, Tuccilli, Chiara, additional, Arlot-Bonnemains, Yannick, additional, Chesnel, Frank, additional, Sorrenti, Salvatore, additional, De Vito, Corrado, additional, Catania, Antonio, additional, D'Armiento, Eleonora, additional, Antonelli, Alessandro, additional, Fallahi, Poupak, additional, Watutantrige-Fernando, Sara, additional, Tartaglia, Francesco, additional, Barollo, Susi, additional, Mian, Caterina, additional, Bononi, Marco, additional, Arceri, Stefano, additional, Mascagni, Domenico, additional, Vergine, Massimo, additional, Pironi, Daniele, additional, Monti, Massimo, additional, Filippini, Angelo, additional, and Ulisse, Salvatore, additional

Published
2017
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25. Duodenal tumors: four case reports

Author

Pasta, Vittorio, Biffoni, Marco, Martino, Giovanni, Malavenda, Ms, Sottile, D, Marinaccio, L, Merola, R, Vergine, Massimo, Bernieri, Mg, Monti, Massimo, Redler, Adriano, and Bernieri, MARIA GIULIA

Subjects
Adult, Male, Duodenal Neoplasms, Humans, Female, Middle Aged, Aged, Duodenal cancer, Duodenal carcinoid, Duodenal somathostatinoma, Duodenal surgery
Abstract

We report 4 cases of neuroendocrine tumors of the duodenum. Signs and symptoms were non-specific. The choice of surgery depended on the site and stage of the tumor and any concomitant diseases.

Published
2013

32. Pseudosarcomatous lesions: report of two cases

Author

Pasta, Vittorio, Torcasio, A, Tintisona, O, Veneroso, S, Sardella, B, Vergine, Massimo, Amabile, MARIA IDA, D'Aulerio, A, Chiarini, S, Stella, S, and Monti, Massimo

Published
2006

34. [Rare pathology of the breast: adenoma of the nipple]

Author

Bianchini, G. P., De Villa, F., Vergine, Massimo, Pasta, Vittorio, and Monti, Massimo

Subjects
Adenoma, Adult, Diagnosis, Differential, Nipples, Humans, Breast Neoplasms, Female
Abstract

Adenoma of the nipple is a benign pathology which histologically interests the epithelium of the galactophorous ducts. This pathology looks like Paget's disease both macroscopically and microscopically, therefore an exact differential histologic diagnosis is needed with the breast's carcinoma to undertake the most timely surgical therapy.

Published
2002

35. [Mesothelial cyst of the diaphragm. Report of a case and review of the literature]

Author

Martino, Giovanni, Braccioni, A., Vergine, Massimo, Calvitti, M., Cariati, S., Veneroso, S., Antonucci, D., Bianchini, G. P., and Monti, Massimo

Subjects
Adult, Male, Muscular Diseases, Cysts, Diaphragm, Humans, Epithelium
Abstract

A case of mesothelial cyst of the right hemidiaphragm in a 44 year old man is reported. Origin (most likely due to a recess of the primary coelomiatic cavity), topographical, histological and therapeutic features are discussed, stressing that it is now more frequently recognised thanks to progress in diagnostic imaging techniques. Complete surgical excision is mandatory to definitely differentiate such lesion from primary diaphragmatic neoplasm, not infrequently malignant.

Published
2000

39. [Criteria of choice in prosthetic surgery of laparocele]

Author

Marco Monti, Antonio Brescia, Vergine, Massimo, Boccaccini, F., Monti, Massimo, Antonucci, D., Bianchini, G. P., Di Matteo, Filippo Maria, Pasta, Vittorio, and Palazzini, Giorgio

Subjects
Adult, Male, Humans, Female, Middle Aged, Surgical Mesh, Tomography, X-Ray Computed, Polytetrafluoroethylene, Hernia, Ventral, Abdominal Muscles, Aged
Abstract

The employment of prosthesis in abdominal plastic surgery for incisional hernia has contributed to a remarkable improvement in the results of this surgery. The current use of PTFEe, according to the Authors experience, proves to be effective. Both satisfactory functional results and evident aesthetic advantages are obtained. The Authors report their experience in the treatment of the median incisional hernia also by means of a polypropylene mesh. The latter was shaped in a very original way thanks to a technique borrowed from plastic surgery. The complete mobilization of the ombilicus, by a circular incision, allowed the Authors to insert this prosthesis symmetrically under the rectus abdominis muscles for the entire extension of the incisional hernia.

Published
1998

40. ['Esthetic' ambulatory phlebectomy per mini-incisions: indications and technique]

Author

Vergine, Massimo, Boccaccini, F., Marco Monti, Antonucci, D., Bianchini, G. P., Pasta, Vittorio, Di Matteo, Filippo Maria, Monti, Massimo, and Mele, M.

Subjects
Adult, Male, Varicose Veins, Ambulatory Surgical Procedures, Humans, Minimally Invasive Surgical Procedures, Female, Bandages, Vascular Surgical Procedures
Published
1998

45. [Mastectomy operation with expected reconstruction of the breast: anatomo-surgical notes]

Author

Marco Monti, Grilli, Paola, Palazzini, Giorgio, Pasta, Vittorio, Lucci, Stefania, Nudo, R., Monti, Massimo, Vergine, Massimo, Rivolta, Riccardo, and Lai, G.

Subjects
Mastectomy, breast reconstruction, Humans, Female, Breast, Surgery, Plastic, Mastectomy, Radical, Surgical Flaps
Abstract

The Authors, on the basis of their experience, underline the importance general surgeon has in carrying out a radical surgery for breast cancer without compromising a subsequent reconstruction. The latter, in fact, is nowadays considered a second step in the surgical management of breast cancer.

Published
1990

49. Thyroglobulin measurement in the washout of fine needle aspirates for the diagnosis of suspicious cervical lymph nodes

Author

Sorrenti, Salvatore, Salvatore Ulisse, Cira di Gioia, Ascoli, Valeria, Bosco, Daniela, Rullo, Emma, Catania, Antonio, Francesco Tartaglia, GIOVANNI CARBOTTA, Nicola, Cornacchini, Arcieri, Stefano, Mascagni, Domenico, MARIA IDA AMABILE, Giacomelli, Laura, Metere, A., daniele, Vergine, Massimo, Monti, Massimo, and Baldini, Enke

Subjects
fine-needle aspiration cytology, cervical lymph node, cytological diagnosis, thyroid cancer, metastasis, thyroglobulin protein assay

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