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2. List of contributors

Author

Adams, John S., primary, Amrein, Karin, additional, Anderson, Paul H., additional, Arnold, Leggy A., additional, Arora, Juhi, additional, Artusa, Patricio, additional, Ascherio, Alberto, additional, Asmussen, Niels C., additional, Astier, Anne L., additional, Bak, Min Ji, additional, Bauerle, Kevin T., additional, Belorusova, Anna Y., additional, Benkusky, Nancy A., additional, Bernal-Mizrachi, Carlos, additional, Bhattoa, Harjit P., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil C., additional, Bischoff-Ferrari, Heike A., additional, Bishop, Charles W., additional, Blomberg Jensen, Martin, additional, Boisen, Ida Marie, additional, Boucher, Barbara J., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Bradford, Dana, additional, Brancatella, Alessandro, additional, Buburuzan, Laura, additional, Burne, Thomas H.J., additional, Buschittari, Damien, additional, Calkins, Hannah, additional, Calvo, Mona S., additional, Camargo, Carlos A., additional, Campbell, Moray J., additional, Cantorna, Margherita T., additional, Cappellani, Daniele, additional, Carlberg, Carsten, additional, Carmeliet, Geert, additional, Cashman, Kevin D., additional, Ceglia, Lisa, additional, Cetani, Filomena, additional, Chang, Wenhan, additional, Cheadle, Charlotte, additional, Chou, Sharon H., additional, Christakos, Sylvia, additional, Christopher, Kenneth B., additional, Chu, Emily Y., additional, Chun, Rene F., additional, Cleal, Jane K., additional, Cobice, Diego F., additional, Cooper, Cyrus, additional, Coort, Susan L.M., additional, Cui, Xiaoying, additional, Curtis, Elizabeth M., additional, Danilenko, Michael, additional, Darling, Andrea L., additional, David Roodman, G., additional, Dawson-Hughes, Bess, additional, de Jongh, Renate, additional, Demay, Marie B., additional, Dennison, Elaine M., additional, Dixon, Katie M., additional, Dong, Bingning, additional, Doroudi, Maryam, additional, Dusso, Adriana, additional, Dvorzhinskiy, Aleksey, additional, Ebeling, Peter R., additional, Erben, Reinhold G., additional, Evelo, Chris T.A., additional, Eyles, Darryl, additional, Feldman, David, additional, Ferrer-Mayorga, Gemma, additional, Fleet, James C., additional, Forcellati, Marianela, additional, Foster, Brian L., additional, Gafni, Rachel I., additional, Gayan-Ramirez, Ghislaine, additional, Giovannucci, Edward, additional, Girgis, Christian M., additional, Glencross, Drew A., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goldfarb, David S., additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Grant, William B., additional, Groves, Natalie J., additional, Gysemans, Conny, additional, Harrison, Stephanie, additional, Harvey, Nicholas C., additional, Haseltine, Katherine, additional, Hawrylowicz, Catherine M., additional, Hayes, Colleen E., additional, Heckel, John E., additional, Hershberger, Pamela A., additional, Hewison, Martin, additional, Högler, Wolfgang, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Holt, Rune, additional, Hujoel, Philippe P., additional, Hyppönen, Elina, additional, Ismailova, Aiten, additional, Jablonski, Nina G., additional, Jakobsen, Jette, additional, Janssens, Wim, additional, Jeffery, Louisa, additional, Jenkinson, Carl, additional, Jensen, Marie Bagge, additional, Jetten, Anton M., additional, Jiang, Heng, additional, Johnson, Candace S., additional, Jones, Glenville, additional, Jones, Kerry S., additional, Jüppner, Harald, additional, Kalia, Vandana, additional, Kallay, Enikö, additional, Karapalis, Andrew C., additional, Kaufmann, Martin, additional, Kiely, Mairead, additional, Kim, Hanseul, additional, Kim, Tiffany Y., additional, Kojima, Hiroyuki, additional, Kooij, Ireen, additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krieger, Kirsten, additional, Kritmetapak, Kittrawee, additional, Krueger, Diane C., additional, Kumar, Rajiv, additional, Kurihara, Noriyoshi, additional, Lane, Joseph M., additional, Lanham-New, Susan A., additional, Latic, Nejla, additional, LeBoff, Meryl S., additional, Lee, Maija B., additional, Lee, Seong Min, additional, Levine, Michael A., additional, Lewis, Richard, additional, Lewis, Rohan M., additional, Li, Wei, additional, Li, Yan Chun, additional, Lincoln, Matthew R., additional, Lips, Paul, additional, Lisse, Thomas S., additional, Liu, Eva S., additional, López de Maturana, Evangelina, additional, Lugg, Sebastian T., additional, Machado, Christopher J., additional, Maes, Karen, additional, Maestro, Miguel A., additional, Malats, Núria, additional, Malloy, Peter J., additional, Manousaki, Despoina, additional, Marcinkowska, Ewa, additional, Marcocci, Claudio, additional, Martens, Pieter-Jan, additional, Martineau, Adrian R., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Mayne, Phoebe, additional, McGrath, John J., additional, Mehta, Mansi, additional, Mellanby, Richard John, additional, Merchant, Nadia, additional, Meyer, Mark B., additional, Miao, Dengshun, additional, Moon, Rebecca J., additional, Mortensen, Li Juel, additional, Motlaghzadeh, Yasaman, additional, Munger, Kassandra L., additional, Muñoz, Alberto, additional, Nakamichi, Yuko, additional, Narvaez, Carmen J., additional, Nikiphorou, Elena, additional, Nonn, Larisa, additional, Pal, Lubna, additional, Parekh, Dhruv, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Pilz, Stefan, additional, Pittas, Anastassios G., additional, Pludowski, Pawel, additional, Prosser, David E., additional, Pullagura, Sri Ramulu N., additional, Raphael, Joseph, additional, Rauz, Saaeha, additional, Raza, Karim, additional, Real, Francisco X., additional, Reichrath, Jörg, additional, Richards, J. Brent, additional, Rivadeneira, Fernando, additional, Rochel, Natacha, additional, Roizen, Jeffrey D., additional, Ryan, Brittany A., additional, Sarkar, Surojit, additional, Sarmadi, Fatemeh, additional, Schafer, Anne L., additional, Schepelmann, Martin, additional, Schoenmakers, Inez, additional, Schuit, Frans, additional, Schwartz, Zvi, additional, Scott, Kayla M., additional, Sellmeyer, Deborah E., additional, Sempos, Christopher T., additional, Sepiashvili, Lusia, additional, Seshadri, Mukund, additional, Shane, Elizabeth, additional, Shaurova, Tatiana, additional, Shieh, Albert, additional, Shui, Irene, additional, Singh, Ravinder J., additional, Slominski, Andrzej T., additional, Smith, Karl W., additional, St-Arnaud, René, additional, Stein, Emily M., additional, Studzinski, George P., additional, Suda, Tatsuo, additional, Takahashi, Naoyuki, additional, Taylor, Hugh S., additional, Tebben, Peter J., additional, Thacher, Tom D., additional, Thandrayen, Kebashni, additional, Thickett, David R., additional, Tiosano, Dov, additional, Trajanoska, Katerina, additional, Tu, Chia-Ling, additional, Tuckey, Robert C., additional, Tutaworn, Teerapat, additional, Udagawa, Nobuyuki, additional, Uday, Suma, additional, Unnanuntana, Aasis, additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Schoor, Natasja, additional, Verlinden, Lieve, additional, Vieth, Reinhold, additional, Vimaleswaran, Karina S., additional, Wagner, Carol L., additional, Wallace, Graham R., additional, Weaver, Connie M., additional, Webb, Daniel A., additional, Welsh, JoEllen, additional, White, John H., additional, Whiting, Susan J., additional, Williams, Emma L., additional, Yahyavi, Sam Kafai, additional, Yamamoto, Keiko, additional, Yates, Clayton, additional, Zagorac, Sladjana, additional, Zhang, Rong Mei, additional, Zhao, Hengguang, additional, Zhou, Ang, additional, and Zittermann, Armin, additional

Published
2024
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6. Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

Author

Llambrich, Sergi, primary, Tielemans, Birger, additional, Saliën, Ellen, additional, Atzori, Marta, additional, Wouters, Kaat, additional, Van Bulck, Vicky, additional, Platt, Mark, additional, Vanherp, Laure, additional, Gallego Fernandez, Nuria, additional, Grau de la Fuente, Laura, additional, Poptani, Harish, additional, Verlinden, Lieve, additional, Himmelreich, Uwe, additional, Croitor, Anca, additional, Attanasio, Catia, additional, Callaerts-Vegh, Zsuzsanna, additional, Gsell, Willy, additional, Martínez-Abadías, Neus, additional, and Vande Velde, Greetje, additional

Published
2024
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7. Author Response: Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

Author

Llambrich, Sergi, primary, Tielemans, Birger, additional, Saliën, Ellen, additional, Atzori, Marta, additional, Wouters, Kaat, additional, Van Bulck, Vicky, additional, Platt, Mark, additional, Vanherp, Laure, additional, Gallego Fernandez, Nuria, additional, Grau de la Fuente, Laura, additional, Poptani, Harish, additional, Verlinden, Lieve, additional, Himmelreich, Uwe, additional, Croitor, Anca, additional, Attanasio, Catia, additional, Callaerts-Vegh, Zsuzsanna, additional, Gsell, Willy, additional, Martínez-Abadías, Neus, additional, and Vande Velde, Greetje, additional

Published
2024
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9. Vitamin D and Bone

Author

Christakos, Sylvia, Li, Shanshan, DeLa Cruz, Jessica, Verlinden, Lieve, Carmeliet, Geert, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Wang, KeWei, Editorial Board Member, and Stern, Paula H., editor

Published
2020
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12. Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

Author

Llambrich, Sergi, primary, Tielemans, Birger, additional, Saliën, Ellen, additional, Atzori, Marta, additional, Wouters, Kaat, additional, Van Bulck, Vicky, additional, Platt, Mark, additional, Vanherp, Laure, additional, Gallego Fernandez, Nuria, additional, Grau de la Fuente, Laura, additional, Poptani, Harish, additional, Verlinden, Lieve, additional, Himmelreich, Uwe, additional, Croitor, Anca, additional, Attanasio, Catia, additional, Callaerts-Vegh, Zsuzsanna, additional, Gsell, Willy, additional, Martínez-Abadías, Neus, additional, and Velde, Greetje Vande, additional

Published
2023
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15. Corrigendum to “Lithocholic acid-based design of noncalcemic vitamin D receptor agonists” [Bioorg. Chem. 111 (2021) 104878]

Author

Gaikwad, Sunil, primary, González, Carmen M., additional, Vilariño, Daniel, additional, Lasanta, Gonzalo, additional, Villaverde, Carmen, additional, Mouriño, Antonio, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Peluso-Iltis, Carole, additional, Rochel, Natacha, additional, Berkowska, Klaudia, additional, and Marcinkowska, Ewa, additional

Published
2023
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17. Vitamin D and Bone

Author

Christakos, Sylvia, primary, Li, Shanshan, additional, DeLa Cruz, Jessica, additional, Verlinden, Lieve, additional, and Carmeliet, Geert, additional

Published
2019
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18. Supplementary Table 1 from The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor−/Progesterone Receptor−/HER-2− Breast Carcinomas

Author

Verlinden, Lieve, primary, Vanden Bempt, Isabelle, primary, Eelen, Guy, primary, Drijkoningen, Maria, primary, Verlinden, Ilse, primary, Marchal, Kathleen, primary, De Wolf-Peeters, Christiane, primary, Christiaens, Marie-Rose, primary, Michiels, Luc, primary, Bouillon, Roger, primary, and Verstuyf, Annemieke, primary

Published
2023
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21. Analogs of Calcitriol

Author

Verlinden, Lieve, primary, Bouillon, Roger, additional, De Clercq, Pierre, additional, and Verstuyf, Annemieke, additional

Published
2018
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22. List of Contributors

Author

Adams, John S., primary, Adams, Judith E., additional, Alsalem, Jawaher A., additional, Anderson, Paul H., additional, Andreopoulou, Panagiota, additional, Angellotti, Edith, additional, Arnold, Leggy A., additional, Atkins, Gerald J., additional, Barbáchano, Antonio, additional, Bassuk, Shari S., additional, Beaudin, Sarah, additional, Belorusova, Anna Y., additional, Benkusky, Nancy A., additional, Bernal-Mizrachi, Carlos, additional, Bhan, Ishir, additional, Bhattoa, Harjit P., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil C., additional, Bischoff-Ferrari, Heike A., additional, Bishop, Charles W., additional, Boisen, Ida M., additional, Bonelli, Fabrizio, additional, Boskey, Adele L., additional, Boucher, Barbara J., additional, Bouillon, Roger, additional, Bouttier, Manuella, additional, Boyan, Barbara D., additional, Bruce, Danny, additional, Buburuzan, Laura, additional, Burghardt, Andrew J., additional, Burne, Thomas H.J., additional, Calvo, Mona S., additional, Camargo Jr., Carlos A., additional, Cannata-Andia, Jorge B., additional, Cantorna, Margherita T., additional, Carlberg, Carsten, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Carter, Graham D., additional, Cashman, Kevin D., additional, Ceglia, Lisa, additional, Christakos, Sylvia, additional, Christopher, Kenneth B., additional, Chun, Rene F., additional, Coe, Fredric L., additional, Coffman, Frederick, additional, Compston, Juliet, additional, Cooper, Cyrus, additional, Curtis, Elizabeth M., additional, Cusano, Natalie E., additional, Danilenko, Michael, additional, David Roodman, G., additional, Dawson-Hughes, Bess, additional, De Clercq, Pierre, additional, DeLuca, Hector F., additional, Demaret, Julie, additional, Demay, Marie B., additional, Dempster, David W., additional, Dennison, Elaine M., additional, Dhawan, Puneet, additional, Dimitrov, Vassil, additional, Dixon, Katie M., additional, Doroudi, Maryam, additional, Doyle, Shevaun M., additional, Dusso, Adriana S., additional, Dvorzhinskiy, Aleksey, additional, Ebeling, Peter R., additional, Eisman, John A., additional, Emkey, Gregory R., additional, Epstein Jr., Ervin H., additional, Epstein, Sol, additional, Eyles, Darryl, additional, Favus, Murray J., additional, Feldman, David, additional, Ferrer-Mayorga, Gemma, additional, Findlay, David M., additional, Fleet, James C., additional, Foster, Brian L., additional, Franceschi, Renny T., additional, Fraser, David R., additional, Furst, Jessica M., additional, Gafni, Rachel I., additional, Giovannucci, Edward, additional, Girgis, Christian M., additional, Gleason, James L., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Graeff-Armas, Laura A., additional, Grant, William B., additional, Groves, Natalie J., additional, Gysemans, Conny, additional, Hansen, Lasse Bøllehuus, additional, Harvey, Nicholas C., additional, Hawrylowicz, Catherine M., additional, Hayes, Colleen E., additional, Heaney, Robert P., additional, Hendy, Geoffrey N., additional, Hershberger, Pamela A., additional, Hewison, Martin, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Hujoel, Philippe P., additional, Hyppönen, Elina, additional, Insogna, Karl L., additional, Jablonski, Nina G., additional, Jensen, Martin Blomberg, additional, Jolliffe, David A., additional, Jones, Glenville, additional, Jones, Kerry S., additional, Jüppner, Harald, additional, Kallay, Enikö, additional, Karaplis, Andrew C., additional, Kaufmann, Martin, additional, Kiely, Mairead, additional, Kim, Tiffany Y., additional, Konrad, Martin, additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krug, Roland, additional, Kumar, Rajiv, additional, Kurihara, Noriyoshi, additional, Laing, Emma, additional, Lane, Joseph M., additional, Larner, Dean P., additional, Larriba, María Jesús, additional, Laverny, Gilles, additional, Le Roy, Nathalie, additional, Lee, Seong M., additional, Levine, Michael A., additional, Lewis, Richard, additional, Lips, Paul, additional, Lisse, Thomas S., additional, Liu, Eva S., additional, Liu, Philip T., additional, Li, Yan, additional, Li, Yan Chun, additional, MacKrell, James G., additional, Mady, Leila J., additional, Majumdar, Sharmila, additional, Makishima, Makoto, additional, Malloy, Peter J., additional, Mann, Elizabeth H., additional, Manson, JoAnn E., additional, Martineau, Adrian R., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Matsumoto, Toshio, additional, Matthews, Donald G., additional, McGrath, John J., additional, Metzger, Daniel, additional, Meyer, Mark B., additional, Miao, Denshun, additional, Mizwicki, Mathew T., additional, Moon, Rebecca J., additional, Morris, Howard A., additional, Mortensen, Li J., additional, Muñoz, Alberto, additional, Nakamichi, Yuko, additional, Narvaez, Carmen J., additional, Nashold, Faye E., additional, Naveh-Many, Tally, additional, Nielson, Carrie M., additional, Norman, Anthony W., additional, Nys, Yves, additional, Onal, Melda, additional, Pal, Lubna, additional, Patterson, Kristine Y., additional, Pauwels, Steven, additional, Pehrsson, Pamela R., additional, Petkovich, Martin, additional, Pettifor, John M., additional, Pfeffer, Paul E., additional, Phillips, Katherine M., additional, Pike, J. Wesley, additional, Pilz, Stefan, additional, Pittas, Anastassios G., additional, Pludowski, Pawel, additional, Prosser, David E., additional, Pullagura, Sri Ramulu N., additional, Quarles, L. Darryl, additional, Rajagopal, Rithwick, additional, Ransohoff, Katherine J., additional, Rauz, Saaeha, additional, Rebolledo, Brian J., additional, Reichrath, Jörg, additional, Rieger, Sandra, additional, Riek, Amy E., additional, Rochel, Natacha, additional, Roizen, Jeffrey D., additional, Roseland, Janet M., additional, Rosen, Cliff, additional, Rybchyn, Mark S., additional, Saitoh, Hiroshi, additional, Salehi-Tabar, Reyhaneh, additional, Schafer, Anne L., additional, Schlingmann, Karl P., additional, Schoenmakers, Inez, additional, Schwartz, Zvi, additional, Scott, Kayla, additional, Sempos, Christopher T., additional, Sepiashvili, Lusia, additional, Seshadri, Mukund, additional, Shane, Elizabeth, additional, Shaurova, Tatiana, additional, Shui, Irene, additional, Silver, Justin, additional, Singh, Ravinder J., additional, Skingle, Linda, additional, St-Arnaud, René, additional, Starr, Jessica, additional, Stayrook, Keith R., additional, Stein, Emily M., additional, Stites, Ryan E., additional, Studzinski, George P., additional, Suda, Tatsuo, additional, Takahashi, Fumiaki, additional, Takahashi, Naoyuki, additional, Tang, Jean Y., additional, Taylor, Christine L., additional, Taylor, Hugh S., additional, Tebben, Peter J., additional, Thacher, Thomas D., additional, Thadhani, Ravi, additional, Thandrayen, Kebashni, additional, Thys-Jacobs, Susan, additional, Tiosano, Dov, additional, Toni, Roberto, additional, Towler, Dwight A., additional, Trump, Donald L., additional, Udagawa, Nobuyuki, additional, Uitterlinden, André G., additional, Unnanuntana, Aasis, additional, van de Peppel, Jeroen, additional, van der Eerden, Bram C.J., additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Schoor, Natasja, additional, Vanherwegen, An-Sofie, additional, Vazirnia, Aria, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Vieth, Reinhold, additional, Wagner, Carol L., additional, Wallace, Graham R., additional, Weaver, Connie, additional, Welsh, JoEllen, additional, White, John H., additional, Whiting, Susan J., additional, Whyte, Michael P., additional, Wysolmerski, John J., additional, Yamada, Sachiko, additional, Yu, Olivia B., additional, Zavala, Kathryn, additional, Zechner, Christoph, additional, Zeytinoglu, Meltem, additional, and Zhao, Hengguang, additional

Published
2018
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28. The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D3 Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer

Author

Vanhevel, Justine, primary, Verlinden, Lieve, additional, Loopmans, Shauni, additional, Doms, Stefanie, additional, Janssens, Iris, additional, Bevers, Sien, additional, Stegen, Steve, additional, Wildiers, Hans, additional, and Verstuyf, Annemieke, additional

Published
2022
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29. High Serum Vitamin D Concentrations, Induced via Diet, Trigger Immune and Intestinal Microbiota Alterations Leading to Type 1 Diabetes Protection in NOD Mice

Author

Martens, Pieter-Jan, primary, Centelles-Lodeiro, Javier, additional, Ellis, Darcy, additional, Cook, Dana Paulina, additional, Sassi, Gabriele, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Raes, Jeroen, additional, Mathieu, Chantal, additional, and Gysemans, Conny, additional

Published
2022
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32. Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐nor‐vitamin D3. Key Enzymatic Desymmetrization of A‐Ring Synthon Precursor.

Author

González‐García, Tania, Verstuyf, Annemieke, Verlinden, Lieve, Fernández, Susana, and Ferrero, Miguel

Subjects
VITAMIN D receptors, AMINO group, BURKHOLDERIA cepacia, HYDROXYL group, CARRIER proteins, VITAMIN D
Abstract

Three novel 19‐nor‐1α,25‐dihydroxyvitamin D3 derivatives modified at C1 and/or C3 with an amino group were synthesized to study the influence of the substitution of one or both hydroxyl groups of A‐ring by amino groups on the affinity for vitamin D receptor (VDR) and vitamin D binding protein (hDBP), and also on the antiproliferative activity. The A‐ring precursors were prepared from cis,cis‐1,3,5‐cyclohexanetriol applying a desymmetrization reaction of a prochiral 1,3‐diol catalyzed by Pseudomonas cepacia lipase as a key step. The structural elucidation of diastereoisomers were unambiguously assigned by NMR spectroscopy. [ABSTRACT FROM AUTHOR]

Published
2023
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37. The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D3 Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer

Author

Vanhevel, Justine, Verlinden, Lieve, Loopmans, Shauni, Doms, Stefanie, Janssens, Iris, Bevers, Sien, Stegen, Steve, Wildiers, Hans, and Verstuyf, Annemieke

Subjects
TRIPLE-negative breast cancer, CYCLIN-dependent kinase inhibitors, CELL cycle proteins, ERGOCALCIFEROL, CALCITRIOL, BREAST cancer, ANTINEOPLASTIC agents
Abstract

Active vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], and its synthetically derived analogs possess potent anticancer properties. In breast cancer (BC) cells, 1,25(OH)2D3 blocks cell proliferation and induces apoptosis through different cell-type specific mechanisms. In this study, we evaluated if the combination of the potent vitamin D3 analog, inecalcitol, with a selective CDK4/6 inhibitor, palbociclib, enhanced the antiproliferative effects of both single compounds in hormone-sensitive (ER+) BC, for which palbociclib treatment is already approved, but also in triple-negative BC (TNBC). Inecalcitol and palbociclib combination treatment decreased cell proliferation in both ER+ (T47D-MCF7) and TNBC (BT20-HCC1143-Hs578T) cells, with a more pronounced antiproliferative effect in the former. In ER+ BC cells, the combination therapy downregulated cell cycle regulatory proteins (p)-Rb and (p)-CDK2 and blocked G1-S phase transition of the cell cycle. Combination treatment upregulated p-mTOR and p-4E-BP1 protein expression in MCF7 cells, whereas it suppressed expression of these proteins in BT20 cells. Cell survival was decreased after inecalcitol treatment either alone or combined in MCF7 cells. Interestingly, the combination therapy upregulated mitochondrial ROS and mitotracker staining in both cell lines. Furthermore, in vivo validation in a MCF7 cell line-derived xenograft mouse model decreased tumor growth and cell cycle progression after combination therapy, but not in a TNBC BT20 cell line-derived xenograft model. In conclusion, we show that addition of a potent vitamin D3 analog to selective CDK4/6 inhibitor treatment results in increased antiproliferative effects in ER+ BC both in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Analysis of 1,25-Dihydroxyvitamin D 3 Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids

Author

Li, Shanshan, primary, De La Cruz, Jessica, additional, Hutchens, Steven, additional, Mukhopadhyay, Somshuvra, additional, Criss, Zachary K., additional, Aita, Rohit, additional, Pellon-Cardenas, Oscar, additional, Hur, Joseph, additional, Soteropoulos, Patricia, additional, Husain, Seema, additional, Dhawan, Puneet, additional, Verlinden, Lieve, additional, Carmeliet, Geert, additional, Fleet, James C., additional, Shroyer, Noah F., additional, Verzi, Michael P., additional, and Christakos, Sylvia, additional

Published
2020
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40. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice

Author

Yu, Vionnie W.C., Ambartsoumian, Gourgen, Verlinden, Lieve, Moir, Janet M., Prud'homme, Josee, Gauthier, Claude, Roughley, Peter J., and St-Arnaud, Rene

Subjects
Genetic transcription -- Research, Genetically modified mice -- Research, Cytology -- Research, Bones -- Density, Bones -- Research, Bones -- Genetic aspects, Biological sciences
Abstract

We report the characterization of factor inhibiting activating transcription factor 4 (ATF4)--mediated transcription (FIAT), a leucine zipper nuclear protein. FIAT interacted with ATF4 to inhibit binding of ATF4 to DNA and block ATF4-mediated transcription of the osteocalcin gene in vitro. Transgenic mice overexpressing FIAT in osteoblasts also had reduced osteocalcin gene expression and decreased bone mineral density, bone volume, mineralized volume, trabecular thickness, trabecular number, and decreased rigidity of long bones. Mineral homeostasis, osteoclast number and activity, and osteoblast proliferation and apoptosis were unchanged in transgenics. Expression of osteoblastic differentiation markers was largely unaffected and type 1 collagen synthesis was unchanged. Mineral apposition rate was reduced in transgenic mice, suggesting that the lowered bone mass was due to a decline in osteoblast activity. This cell-autonomous decrease in osteoblast activity was confirmed by measuring reduced alkaline phosphatase activity and mineralization in primary osteoblast cultures. These results show that FIAT regulates bone mass accrual and establish FIAT as a novel transcriptional regulator of osteoblastic function.

Published
2005

41. List of contributors

Author

Adams, John S., Amrein, Karin, Anderson, Paul H., Arnold, Leggy A., Arora, Juhi, Artusa, Patricio, Ascherio, Alberto, Asmussen, Niels C., Astier, Anne L., Bak, Min Ji, Bauerle, Kevin T., Belorusova, Anna Y., Benkusky, Nancy A., Bernal-Mizrachi, Carlos, Bhattoa, Harjit P., Bikle, Daniel D., Bilezikian, John P., Binkley, Neil C., Bischoff-Ferrari, Heike A., Bishop, Charles W., Blomberg Jensen, Martin, Boisen, Ida Marie, Boucher, Barbara J., Bouillon, Roger, Boyan, Barbara D., Bradford, Dana, Brancatella, Alessandro, Buburuzan, Laura, Burne, Thomas H.J., Buschittari, Damien, Calkins, Hannah, Calvo, Mona S., Camargo, Carlos A., Jr., Campbell, Moray J., Cantorna, Margherita T., Cappellani, Daniele, Carlberg, Carsten, Carmeliet, Geert, Cashman, Kevin D., Ceglia, Lisa, Cetani, Filomena, Chang, Wenhan, Cheadle, Charlotte, Chou, Sharon H., Christakos, Sylvia, Christopher, Kenneth B., Chu, Emily Y., Chun, Rene F., Cleal, Jane K., Cobice, Diego F., Cooper, Cyrus, Coort, Susan L.M., Cui, Xiaoying, Curtis, Elizabeth M., Danilenko, Michael, Darling, Andrea L., David Roodman, G., Dawson-Hughes, Bess, de Jongh, Renate, Demay, Marie B., Dennison, Elaine M., Dixon, Katie M., Dong, Bingning, Doroudi, Maryam, Dusso, Adriana, Dvorzhinskiy, Aleksey, Ebeling, Peter R., Erben, Reinhold G., Evelo, Chris T.A., Eyles, Darryl, Feldman, David, Ferrer-Mayorga, Gemma, Fleet, James C., Forcellati, Marianela, Foster, Brian L., Gafni, Rachel I., Gayan-Ramirez, Ghislaine, Giovannucci, Edward, Girgis, Christian M., Glencross, Drew A., Glorieux, Francis H., Gocek, Elzbieta, Goldfarb, David S., Goltzman, David, González-Sancho, José Manuel, Grant, William B., Groves, Natalie J., Gysemans, Conny, Harrison, Stephanie, Harvey, Nicholas C., Haseltine, Katherine, Hawrylowicz, Catherine M., Hayes, Colleen E., Heckel, John E., Hershberger, Pamela A., Hewison, Martin, Högler, Wolfgang, Holick, Michael F., Hollis, Bruce W., Holt, Rune, Hujoel, Philippe P., Hyppönen, Elina, Ismailova, Aiten, Jablonski, Nina G., Jakobsen, Jette, Janssens, Wim, Jeffery, Louisa, Jenkinson, Carl, Jensen, Marie Bagge, Jetten, Anton M., Jiang, Heng, Johnson, Candace S., Jones, Glenville, Jones, Kerry S., Jüppner, Harald, Kalia, Vandana, Kallay, Enikö, Karapalis, Andrew C., Kaufmann, Martin, Kiely, Mairead, Kim, Hanseul, Kim, Tiffany Y., Kojima, Hiroyuki, Kooij, Ireen, Kovacs, Christopher S., Kremer, Richard, Krieger, Kirsten, Kritmetapak, Kittrawee, Krueger, Diane C., Kumar, Rajiv, Kurihara, Noriyoshi, Lane, Joseph M., Lanham-New, Susan A., Latic, Nejla, LeBoff, Meryl S., Lee, Maija B., Lee, Seong Min, Levine, Michael A., Lewis, Richard, Lewis, Rohan M., Li, Wei, Li, Yan Chun, Lincoln, Matthew R., Lips, Paul, Lisse, Thomas S., Liu, Eva S., López de Maturana, Evangelina, Lugg, Sebastian T., Machado, Christopher J., Maes, Karen, Maestro, Miguel A., Malats, Núria, Malloy, Peter J., Manousaki, Despoina, Marcinkowska, Ewa, Marcocci, Claudio, Martens, Pieter-Jan, Martineau, Adrian R., Mason, Rebecca S., Mathieu, Chantal, Mayne, Phoebe, McGrath, John J., Mehta, Mansi, Mellanby, Richard John, Merchant, Nadia, Meyer, Mark B., Miao, Dengshun, Moon, Rebecca J., Mortensen, Li Juel, Motlaghzadeh, Yasaman, Munger, Kassandra L., Muñoz, Alberto, Nakamichi, Yuko, Narvaez, Carmen J., Nikiphorou, Elena, Nonn, Larisa, Pal, Lubna, Parekh, Dhruv, Pettifor, John M., Pike, J. Wesley, Pilz, Stefan, Pittas, Anastassios G., Pludowski, Pawel, Prosser, David E., Pullagura, Sri Ramulu N., Raphael, Joseph, Rauz, Saaeha, Raza, Karim, Real, Francisco X., Reichrath, Jörg, Richards, J. Brent, Rivadeneira, Fernando, Rochel, Natacha, Roizen, Jeffrey D., Ryan, Brittany A., Sarkar, Surojit, Sarmadi, Fatemeh, Schafer, Anne L., Schepelmann, Martin, Schoenmakers, Inez, Schuit, Frans, Schwartz, Zvi, Scott, Kayla M., Sellmeyer, Deborah E., Sempos, Christopher T., Sepiashvili, Lusia, Seshadri, Mukund, Shane, Elizabeth, Shaurova, Tatiana, Shieh, Albert, Shui, Irene, Singh, Ravinder J., Slominski, Andrzej T., Smith, Karl W., St-Arnaud, René, Stein, Emily M., Studzinski, George P., Suda, Tatsuo, Takahashi, Naoyuki, Taylor, Hugh S., Tebben, Peter J., Thacher, Tom D., Thandrayen, Kebashni, Thickett, David R., Tiosano, Dov, Trajanoska, Katerina, Tu, Chia-Ling, Tuckey, Robert C., Tutaworn, Teerapat, Udagawa, Nobuyuki, Uday, Suma, Unnanuntana, Aasis, van Driel, Marjolein, van Leeuwen, Johannes P.T.M., van Schoor, Natasja, Verlinden, Lieve, Vieth, Reinhold, Vimaleswaran, Karina S., Wagner, Carol L., Wallace, Graham R., Weaver, Connie M., Webb, Daniel A., Welsh, JoEllen, White, John H., Whiting, Susan J., Williams, Emma L., Yahyavi, Sam Kafai, Yamamoto, Keiko, Yates, Clayton, Zagorac, Sladjana, Zhang, Rong Mei, Zhao, Hengguang, Zhou, Ang, and Zittermann, Armin

Published
2023
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42. Contributors

Author

Abu Dayyeh, Barham K., Agostini, Maura, Aiello, Lloyd Paul, Alicic, Radica Z., Anawalt, Bradley D., Ang, Lynn, Angelidi, Angeliki M., Antonio, Leen, Armstrong, David G., Arner, Peter, Assié, Guillaume, Athonvarangkul, Diana, Auchus, Richard J., Avery, Michael B., Avram, Anca M., Baloch, Zubair W., Bancos, Irina, Barb, Diana, Barkhoudarian, Garni, Basaria, Shehzad, Basham, Kaitlin J., Bashari, Waiel, Bastepe, Murat, Batterham, Rachel L., Bauer, Elizabeth M., Bellin, Melena D., Bertherat, Jérôme, Berthon, Annabel, Bhasin, Shalender, Bilezikian, John P., Billington, Emma O., Boelen, Anita, Bouillon, Roger, Brada, Michael, Brent, Gregory A., Broekmans, Frank J., Bronstein, Marcello D., Brown, Edward M., Bulun, Serdar E., Burch, Henry B., Burghard, Anne Claire, Burney, Richard O., Pop-Busui, Rodica, Cagliero, Enrico, Cameron, Sharon, Caoili, Elaine M., Carmeliet, Geert, Cavallerano, Jerry D., Chatterjee, Krishna, Chen, Zi-Jiang, Cheung, N. Wah, Christian, Helen C., Cidlowski, John A., Clavijo, Leonardo C., Clifton-Bligh, Roderick J., Considine, Robert V., Conti, Marco, Copps, Kyle D., Corcuff, Jean- Benoît, D’Alessio, David, Dattani, Mehul T., Davey, Rachel A., Davis, Stephen N., De Felice, Mario, de Kretser, David, DeFranco, Donald B., Demay, Marie B., DeMayo, Francesco J., De Santis, Pascual, Deutsch, Madeline B., Dhatariya, Ketan, Dhillon, Vaninder K., Di Lauro, Roberto, Dillon, Joseph S., Dinneen, Sean F., Doherty, Gerard M., Donahoo, William Troy, Econs, Michael J., Egan, Aoife M., Ehrhardt, Nicole, Ehrmann, David A., Eisenhofer, Graeme, El-Khairi, Ranna, Elisei, Rossella, Else, Tobias, Erickson, Lori A., Erinjeri, Neeta J., Eszlinger, Markus, Eugster, Erica A., Evert, Alison B., Faix, James D., Farooqi, I. Sadaf, Fassnacht, Martin, Fauser, Bart C.J.M., Findlay, David M., Fliers, Eric, Freeman, Mason W., Frydenberg, Mark, Fuller, Peter J., Gagliano-Jucá, Thiago, Gardella, Thomas J., Garrahy, Aoife, Garvey, W. Timothy, German, Michael S., Gershengorn, Marvin C., Gild, Matti, Gilliam, Lisa K., Giudice, Linda C., Glezer, Andrea, Glorieux, Francis H., Goodpaster, Bret H., Grinman, Diego Y., Guasti, Leonardo, Gurnell, Mark, Habra, Mouhammed Amir, Haddad, Nadine G., Halperin, Daniel M., Hammes, Stephen R., Hardman, Sarah, Harmon, Jamie S., Haugen, Bryan R., Hebrok, Matthias, Hedger, Mark P., Heindel, Jerrold J., Hirsch, Irl B., Hobbs, Robin M., Hollenberg, Anthony N., Hruska, Keith A., Husebye, Eystein, Iacovazzo, Donato, Ilie, Mirela Diana, Imel, Erik A., Isaac, Adam L., Jameson, J. Larry, Jasuja, Ravi, Jayasena, Channa N., Johannsson, Gudmundur, Jones, Glenville, Jonklaas, Jacqueline, Jørgensen, Niels, Jüppner, Harald, Juul, Anders, Kahaly, George J., Karavitaki, Niki, Katugampola, Harshini, Keevil, Brian, Kelley, David E., Kellogg, Todd Andrew, Kelly, David F., Klein, Ronald, Kleinau, Gunnar, Koniares, Katherine, Kopp, Peter, Korbonits, Márta, Korevaar, Tim I.M., Koulouri, Olympia, Krausz, Csilla, Kronenberg, Henry M., La Greca, Amanda, Lamos, Elizabeth M., Lebovitz, Harold E., Hong Lee, Alan Chun, Legro, Richard S., Lenders, Jacques W.M., Lerario, Antonio M., Lernmark, Åke, Lightman, Stafford L., Lin, David S., Liu, Eva S., Lo, Janet, Loomba, Lindsey A., Loveland, Kate L., Lue, Tom F., Lundgren, Markus, MacFarlane, James Robert, Magee, Gregory A., Maes, Christa, Maharaj, Avinaash, Main, Katharina M., Makaronidis, Janine M., Malina, Robert, Mannstadt, Michael, Manohar, Paul, Mantzoros, Christos S., Marazuela, Mónica, Matrone, Antonio, Maxwell, Jessica E., McCartney, Christopher R., McGee, Elizabeth A., Melanson, Edward L., Melmed, Shlomo, Mendelson, Carole R., Merke, Deborah P., Mesiano, Sam, Metherell, Louise A., Miller, Barbra S., Mizokami-Stout, Kara, Mohan, Dipika R., Molitch, Mark E., Moran, Carla, Moravek, Molly B., Neumann, Susanne, Neumiller, Joshua J., Newell-Price, John D.C., Newey, Paul J., Norwitz, Errol R., O’Donnell, Liza, O’Rahilly, Stephen, Oakley, Robert H., Oberfield, Sharon E., Orellana, Minerva, Mete, Ozgur, Pacak, Karel, Pace-Asciak, Pia, Page, Stephanie T., Paschke, Ralf, Pasquel, Francisco J., Pearce, Elizabeth N., Peters, Anne L., Pook, David W., Potts, Callum A., Potts, John T., Jr, Purcell, Sarah A., Raff, Hershel, Ragnarsson, Oskar, Rajpert-De Meyts, Ewa, Ramos-Levi, Ana M., Rao, Sarika N., Rastrelli, Giulia, Raverot, Gérald, Ray, David W., Razavi, Christopher R., Reed-Maldonado, Amanda B., Reid, Ian R., Retnakaran, Ravi, Rickels, Michael R., Riddell, Michael Charles, Rinaudo, Paolo, Risbridger, Gail P., Robertson, R. Paul, Robinson, Bruce G., Rogol, Alan D., Romei, Cristina, Rosenfelder, Nicola, Rowen, Tami S., Ruderman, Neil B., Rushing, John, Russell, Jonathon O., Russo, Jose, Rydén, Mikael, Santoro, Nanette, Schlegel, Peter N., Schoenmakers, Erik, Schoenmakers, Nadia, Senanayake, Russell Martin, Shaear, Mohammad, Shalev, Anath, Shields, James, Shimy, Kim, Shindel, Alan W., Shulman, Gerald I., Silva, Paolo S., Simmons, David, Simon, James A., Singer, Frederick R., Sipos, Jennifer A., Skaznik-Wikiel, Malgorzata E., Smallridge, Robert C., Smith, Christopher J., Smith, Roger, Smith, Ulf, Snyder, Peter J., Solda, Francesca, Speiser, Phyllis W., St-Arnaud, René, Stewart, Elizabeth A., Stowasser, Michael, Straseski, Joely, Strauss, Jerome F., III, Styne, Dennis M., Swerdloff, Ronald S., Tabarin, Antoine, Tanavde, Ved, Taïeb, David, Thakker, Rajesh V., Thompson, Christopher J., Timmers, Henri J.L.M., Toppari, Jorma, Torpy, David J., Tsang, Venessa, Tsoukas, Michael A., Tufano, Ralph P., Tuttle, Katherine R., Udelsman, Robert, Umpierrez, Guillermo, Upton, Thomas J., Vaidya, Anand, Val, Pierre, Vasiljevic, Alexandre, Vaughan, Denis A., Vella, Adrian, Verlinden, Lieve, Vietor, Nicole O., Viglianti, Benjamin L., Vilain, Eric, Barisson Villares Fragoso, Maria Candida, Visser, W. Edward, Walford, Geoffrey, Walker, Marcella D., Wang, Christina, Weetman, Anthony P., Wei, Daimin, White, Kenneth E., White, Morris F., White, Perrin C., Whyte, Michael P., Williams, Matthew James, Witchel, Selma Feldman, Wong, Ka Kit, Wu, Frederick C.W., Wysolmerski, John J., Young, Morag J., Zennaro, Maria-Christina, Zimmerman, Michael B., and Zoeller, R. Thomas

Published
2023
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43. Contributors

Author

Abrams, Steven A., primary, Adams, John S., additional, Adams, Judith E., additional, Adorini, Luciano, additional, Anderson, Paul H., additional, Arab, Lenore, additional, Atkins, Gerald J., additional, Berdal, Ariane, additional, Bhan, Ishir, additional, Bikle, Daniel, additional, Bilezikian, John P., additional, Bischoff-Ferrari, Heike, additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Brown, Alex J., additional, Brown, Edward M., additional, Bruce, Danny, additional, Burghardt, Andrew J., additional, Burne, Thomas, additional, Calvo, Mona S., additional, Camargo, Carlos A., additional, Cantorna, Margherita, additional, Carlberg, Carsten, additional, Carpenter, Thomas O., additional, Carson, Matthew W., additional, Ceglia, Lisa, additional, Chen, Hong, additional, Chen, Songcang, additional, Christakos, Sylvia, additional, Coe, Fredric L., additional, Compston, Juliet, additional, Cross, Heide S., additional, Cusano, Natalie E., additional, Dawson-Hughes, Bess, additional, De Clercq, Pierre, additional, DeLuca, Hector, additional, Danilenko, Michael, additional, David, Valentin, additional, Deluca, Hector F., additional, Demay, Marie B., additional, de Paula, Francisco J.A., additional, Descroix, Vianney, additional, Dhawan, Puneet, additional, Dixon, Katie M., additional, Dobnig, Harald, additional, Dodge, Jeffrey A., additional, Donnelly, Eve, additional, Doroudi, Maryam, additional, Dowd, Diane R., additional, Drezner, Marc K., additional, Dusso, Adriana S., additional, Ebeling, Peter R., additional, Edouard, Thomas, additional, Eelen, Guy, additional, Eisman, John A., additional, Epps, Tina, additional, Epstein, Ervin H., additional, Epstein, Sol, additional, Eyles, Darryl, additional, Farach-Carson, Mary C., additional, Favus, Murray J., additional, Feldman, David, additional, Findlay, David M., additional, Fleet, James C., additional, Franceschi, Renny T., additional, Fujiki, Ryoji, additional, Gardner, David G., additional, Ginde, Adit A., additional, Giovannucci, Edward, additional, Glenn, Denis J., additional, Glorieux, Francis H., additional, Gocek, Elzbieta, additional, Goltzman, David, additional, González-Sancho, José Manuel, additional, Gordon-Thomson, Clare, additional, Gysemans, Conny, additional, Hansen, Karen E., additional, Haussler, Carol A., additional, Haussler, Mark R., additional, Hayes, Colleen E., additional, Heaney, Robert P., additional, Helvig, Christian, additional, Hendy, Geoffrey N., additional, Hewison, Martin, additional, Hirsch, Arnold Lippert, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Holt, Elizabeth, additional, Hsieh, Jui-Cheng, additional, Insogna, Karl L., additional, Johnson, Candace, additional, Jones, Glenville, additional, Jurutka, Peter W., additional, Kalkwarf, Heidi J., additional, Kato, Shigeaki, additional, Kliewer, Steven A., additional, Koeffler, H. Phillip, additional, Korf, Hannelie, additional, Kouzmenko, Alexander, additional, Kovacs, Christopher S., additional, Kream, Barbara E., additional, Kremer, Richard, additional, Krishnan, Aruna V., additional, Krug, Roland, additional, Kubodera, Noboru, additional, Kumar, Rajiv, additional, Laing, Emma M., additional, Lane, Joseph M., additional, Larriba, María Jesús, additional, Lee, Seong Min, additional, Lewis, Richard D., additional, Li, Yan, additional, Li, Yan Chun, additional, Lian, Jane B., additional, Lichtler, Alexander C., additional, Lips, Paul, additional, Liu, Philip T., additional, Lisse, Thomas S., additional, Ma, Yanfei L., additional, MacDonald, Paul N., additional, Mady, Leila, additional, Maggi, Mario, additional, Majumdar, Sharmila, additional, Makishima, Makoto, additional, Malloy, Peter J., additional, Mangelsdorf, David J., additional, Mansbach, Jonathan M., additional, Manson, JoAnn E., additional, Mason, Rebecca S., additional, Mathieu, Chantal, additional, Mayne, Christopher G., additional, McAlindon, Timothy M., additional, McGrath, John, additional, Meyer, Mark B., additional, Mizwicki, Mathew T., additional, Molla, Muriel, additional, Montecino, Martin, additional, Moras, Dino, additional, Morelli, Annamaria, additional, Morris, Howard A., additional, Muñoz, Alberto, additional, Nanes, Mark S., additional, Nashold, Faye E., additional, Naveh-Many, Tally, additional, Ni, Wei, additional, Nelson, Corwin D., additional, Norman, Anthony W., additional, Ohtake, Fumiaki, additional, Okamoto, Ryoko, additional, Okereke, Olivia I., additional, Pal, Lubna, additional, Petkovich, Martin, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Pittas, Anastassios G., additional, Plum, Lori A., additional, Prosser, David E., additional, Quarles, L. Darryl, additional, Rebolledo, Brian J., additional, Reichrath, Jörg, additional, Rochel, Natacha, additional, Rosen, Clifford J., additional, Ross, F. Patrick, additional, Sambrook, Philip, additional, Schmidt, Daniel R., additional, Schoch, Ryan D., additional, Schwartz, Gary G., additional, Schwartz, Zvi, additional, Sequeira, Vanessa, additional, Shane, Elizabeth, additional, Shea, M. Kyla, additional, Silver, Justin, additional, Simpson, Robert U., additional, Skingle, Linda, additional, Slatopolsky, Eduardo, additional, Sourij, Harald, additional, Spanier, Justin A., additional, Specker, Bonny L., additional, St-Arnaud, René, additional, Stayrook, Keith R., additional, Stein, Emily M., additional, Stein, Gary S., additional, Stein, Janet L., additional, Studzinski, George P., additional, Takahashi, Fumiaki, additional, Tang, Jean Y., additional, Taylor, Hugh S., additional, Tebben, Peter, additional, Thadhani, Ravi, additional, Thiex, Natalie W., additional, Thompson, William R., additional, Thys-Jacobs, Susan, additional, Tiosano, Dov, additional, Towler, Dwight A., additional, Trump, Donald, additional, Uitterlinden, André G., additional, Unnanuntana, Aasis, additional, Vandewalle, Maurits, additional, van Driel, Marjolein, additional, van Leeuwen, Johannes P.T.M., additional, van Wijnen, Andre J., additional, van Schoor, Natasja, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Vieth, Reinhold, additional, Weaver, Connie M., additional, Weinstein, Barrie M., additional, Welsh, JoEllen, additional, White, John H., additional, Whitfield, G. Kerr, additional, Whiting, Susan J., additional, Whyte, Michael P., additional, Wysolmerski, John J., additional, Yamada, Sachiko, additional, and Yip, Ian, additional

Published
2011
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44. Analogs of Calcitriol

Author

Verlinden, Lieve, primary, Eelen, Guy, additional, Bouillon, Roger, additional, Vandewalle, Maurits, additional, De Clercq, Pierre, additional, and Verstuyf, Annemieke, additional

Published
2011
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46. Contributors

Author

Adler, Robert A., primary, Allen, Matthew R., additional, Amin, Shreyasee, additional, Antoniucci, Diana M., additional, Araujo, Andre B., additional, Armas, Laura A.G., additional, Baroncelli, Giampiero I., additional, Bertelloni, Silvano, additional, Bhasin, Shalender, additional, Bilezikian, John P., additional, Binkley, Neil C., additional, Boonen, Steven, additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Burr, David B., additional, Burrows, Melonie, additional, Callewaert, Filip, additional, Carmeliet, Geert, additional, Cianferotti, Luisella, additional, Compston, Juliet, additional, Cosman, Felicia, additional, Cremers, Serge, additional, Davison, K. Shawn, additional, Dempster, David W., additional, Eisman, John A., additional, Fuleihan, Ghada El-Hajj, additional, Eriksen, Erik Fink, additional, Favus, Murray J., additional, Felsenberg, Dieter, additional, Ferrari, Serge, additional, Fyhrie, David P., additional, Garnero, Patrick, additional, Gennari, Luigi, additional, Geusens, Piet, additional, Gilsanz, Vicente, additional, Girotra, Monica, additional, Giusti, Andrea, additional, Giustina, Andrea, additional, Goemaere, Stefan, additional, Gold, Deborah T., additional, Guo, X. Edward, additional, Haentjens, Patrick, additional, Halse, Johan, additional, Handelsman, David J., additional, Haney, Elizabeth M., additional, Hanley, David A., additional, Heaney, Robert P., additional, Jasuja, Ravi, additional, Johansson, Helena, additional, Kanis, John A., additional, Kaufman, Jean-Marc, additional, Klein, Robert, additional, Kousteni, Stavroula, additional, Krueger, Diane, additional, Lakshman, Kishore M., additional, Lang, Thomas F., additional, Lapauw, Bruno, additional, Lappe, Joan M., additional, Leder, Benjamin Z., additional, Lems, Willem, additional, Liu, X. Sherry, additional, Lu, Shi S., additional, Macdonald, Heather M., additional, Maes, Christa, additional, Maloney, Ann E, additional, Cawthon, Peggy Mannen, additional, Marcocci, Claudio, additional, Marshall, Lynn, additional, Mazziotti, Gherardo, additional, McCloskey, Eugene V., additional, McKay, Heather A., additional, Meier, Christian, additional, Miller, Paul D., additional, Misra, Bismruta, additional, Mora, Stefano, additional, Nguyen, Tuan V., additional, Oden, Anders, additional, Ohlsson, Claes, additional, O’Neill, Terence W., additional, Orwoll, Eric S., additional, Papapoulos, Socrates E., additional, Rizzoli, René, additional, Rosen, Clifford J., additional, Runge, Martin, additional, Schousboe, John T., additional, Seeman, Ego, additional, Seibel, Markus J., additional, Sellmeyer, Deborah E., additional, Shane, Elizabeth, additional, Shapiro, Jay R., additional, Silverberg, Shonni J., additional, Silverman, Stuart L., additional, Singh, Rajan, additional, Stein, Emily M., additional, Storer, Thomas W., additional, Szulc, Pawel, additional, Tabbal, Mahmoud, additional, Taes, Youri, additional, Turner, Charles H., additional, Vandenput, Liesbeth, additional, Vanderschueren, Dirk, additional, Venken, Katrien, additional, Verlinden, Lieve, additional, Verstuyf, Annemieke, additional, Wang, Qingju, additional, Weaver, Connie M., additional, Wehrli, Felix W., additional, Wimalawansa, Sunil J., additional, Wiren, Kristine M., additional, Zebaze, Roger, additional, and Zhou, Hua, additional

Published
2010
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47. Vitamin D and Bone

Author

Bouillon, Roger, primary, Maes, Christa, additional, Verlinden, Lieve, additional, Carmeliet, Geert, additional, and Verstuyf, Annemieke, additional

Published
2010
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48. Local nebulization of 1α,25(OH)2D3 attenuates LPS-induced acute lung inflammation.

Author

Serré, Jef, Mathyssen, Carolien, Ajime, Tom Tanjeko, Heigl, Tobias, Verlinden, Lieve, Maes, Karen, Verstuyf, Annemieke, Cataldo, Didier, Vanoirbeek, Jeroen, Vanaudenaerde, Bart, Janssens, Wim, and Gayan-Ramirez, Ghislaine

Subjects
PNEUMONIA, VITAMIN D deficiency, CHRONIC obstructive pulmonary disease, VITAMIN D, ALPHA 1-antitrypsin deficiency, DIETARY supplements
Abstract

Background: Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supplementation is limited by the potential risk for hypercalcemia. In this study, we investigated if local delivery of vitamin D to the lungs improves vitamin D-mediated anti-inflammatory action in response to acute inflammation without inducing hypercalcemia.Methods: We studied vitamin D sufficient (VDS) or deficient (VDD) mice in whom 1α,25(OH)2D3 (0.2 μg/kg) or a vehicle followed by lipopolysaccharide (LPS 25 µg) were delivered to the lung as a micro-spray.Results: Local 1α,25(OH)2D3 reduced LPS-induced inflammatory cells in bronchoalveolar lavage (BAL) in VDS (absolute number of cells: - 57% and neutrophils - 51% p < 0.01) and tended to diminish LPS-increased CXCL5 BAL levels in VDS (- 40%, p = 0.05) while it had no effect on CXCL1 and CXCL2 in BAL and mRNA in lung of VDS and VDD. It also significantly attenuated the increased IL-13 in BAL and lung, especially in VDD mice (- 41 and - 75%, respectively). mRNA expression of Claudin-18 in lung was significantly lower in VDS mice with local 1α,25(OH)2D3 while Claudin-3, -5 and -8 mRNA levels remained unchanged. Finally, in VDD mice only, LPS reduced lung mRNA expression of adhesion junction Zona-occludens-1, in addition to increasing uric acid and total protein in BAL, which both were prevented by local 1α,25(OH)2D3.Conclusion: Under normal levels of vitamin D, local 1α,25(OH)2D3 nebulization into the lung efficiently reduced LPS induction of inflammatory cells in BAL and slightly attenuated LPS-increase in CXCL5. In case of severe vitamin D deficiency, although local 1α,25(OH)2D3 nebulization failed to significantly minimize cellular inflammation in BAL at this dose, it prevented epithelial barrier leakage and damage in lung. Additional research is needed to determine the potential long-term beneficial effects of local 1α,25(OH)2D3 nebulization on lung inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency

Author

Hatse, Sigrid, Lambrechts, Diether, Verstuyf, Annemieke, Smeets, Ann, Brouwers, Barbara, Vandorpe, Thijs, Brouckaert, Olivier, Peuteman, Gilian, Laenen, Annouschka, Verlinden, Lieve, Kriebitzsch, Carsten, Dieudonné, Anne-Sophie, Paridaens, Robert, Neven, Patrick, Christiaens, Marie-Rose, Bouillon, Roger, and Wildiers, Hans

Published
2012
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