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2. Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials

Author

Blankestijn, Peter J, Vernooij, Robin WM, Hockham, Carinna, Strippoli, Giovanni FM, Canaud, Bernard, Hegbrant, Jörgen, Barth, Claudia, Cromm, Krister, Davenport, Andrew, Rose, Matthias, Török, Marietta, Woodward, Mark, Bots, Michiel, Bots, Michiel L, Grooteman, Muriel PC, Kircelli, Fatih, Locatelli, Franco, Maduell, Francisco, Morena, Marion, Nubé, Menso J, Ok, Ercan, Torres, Ferran, Vernooij, Robin W M, Strippoli, Giovanni, and Green, Suetonia

Published
2024
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7. Reporting of costs and economic impacts in randomized trials of de-implementation interventions for low-value care: a systematic scoping review

Author

Falkenbach, Petra, Raudasoja, Aleksi J., Vernooij, Robin W. M., Mustonen, Jussi M. J., Agarwal, Arnav, Aoki, Yoshitaka, Blanker, Marco H., Cartwright, Rufus, Garcia-Perdomo, Herney A., Kilpeläinen, Tuomas P., Lainiala, Olli, Lamberg, Tiina, Nevalainen, Olli P. O., Raittio, Eero, Richard, Patrick O., Violette, Philippe D., Tikkinen, Kari A. O., Sipilä, Raija, Turpeinen, Miia, and Komulainen, Jorma

Published
2023
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8. Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines

Author

Johnston, Bradley C., Zeraatkar, Dena, Steen, Jeremy, de Jauregui, Diego Rada Fernandez, Zhu, Hongfei, Sun, Mingyao, Cooper, Matthew, Maraj, Malgorzata, Prokop-Dorner, Anna, Reyes, Boris Castro, Valli, Claudia, Storman, Dawid, Karam, Giorgio, Zajac, Joanna, Ge, Long, Swierz, Mateusz J., Ghosh, Nirjhar, Vernooij, Robin W. M., Chang, Yaping, Zhao, Yunli, Thabane, Lehana, Guyatt, Gordon H., Alonso-Coello, Pablo, Hooper, Lee, and Bala, Malgorzata M.

Published
2023
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11. Impact of sodium intake on blood pressure, mortality and major cardiovascular events: an umbrella review of systematic reviews and meta-analyses.

Author

Yang, Qiuyu, Vernooij, Robin W. M., Zhu, Hongfei, Nesrallah, Gihad, Bai, Chunyang, Wang, Qi, Li, Ying, Xia, Danni, Bała, Małgorzata M., Warzecha, Sylwia, Sun, Mingyao, Jayedi, Ahmad, Shab-Bidar, Sakineh, Pan, Bei, Tian, Jinhui, Yang, Kehu, Ge, Long, and Johnston, Bradley C.

Subjects
*SYSTOLIC blood pressure, *MORTALITY, *SODIUM, *BLOOD pressure, *CERTAINTY, *UMBRELLAS
Abstract

AbstractA plethora of systematic reviews with meta-analyses (SRMAs) evaluating sodium intake on cardiovascular health have been published. However, the quality of the SRMAs, that report absolute estimates of effect for major cardiovascular events and the corresponding certainty of the evidence has not been explicitly summarized. We conducted an umbrella review to assess the strength and validity of associations between lower sodium intake and cardiovascular outcomes. We used a modified, more stringent, version of the AMSTAR 2 instrument and the GRADE approach to assess SRMA methodological quality and evidence certainty, respectively. Across three cardiovascular risk strata, we computed the absolute risk reduction (ARR) for binary outcomes. We included 56 SRMAs. In various cardiovascular risk populations, moderate to high certainty evidence suggested that lower sodium intake reduced systolic blood pressure (BP) by −8.69 to −2.00 mmHg, and had concordant but smaller effects on diastolic BP. Salt substitutes conferred a small but important reduction in all-cause and cardiovascular mortality [ARR 12 fewer per 1000; 9 fewer per 1000; respectively], and had little to no effect on the risk of stroke [ARR 1 fewer per 1000]. Moderate to high certainty evidence suggested that lower sodium intake is probably beneficial for the prevention of major cardiovascular events, especially in low cardiovascular risk populations. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials.

Author

Vernooij, Robin W M, Hockham, Carinna, Strippoli, Giovanni, Green, Suetonia, Hegbrant, Jörgen, Davenport, Andrew, Barth, Claudia, Canaud, Bernard, Woodward, Mark, Blankestijn, Peter J, and Bots, Michiel L

Subjects
*PROPORTIONAL hazards models, *RANDOMIZED controlled trials, *NATURAL heat convection, *KIDNEY failure, *MORTALITY
Abstract

High-dose haemodiafiltration has been shown, in a randomised clinical trial, to result in a 23% lower risk of mortality for patients with kidney failure when compared with conventional high-flux haemodialysis. Nevertheless, whether treatment effects differ across subgroups, whether a dose–response relationship with convection volume exists, and the effects on cause-specific mortality remain unclear. The aim of this individual patient data meta-analysis was to compare the effects of haemodiafiltration and standard haemodialysis on all-cause and cause-specific mortality. On July 17, 2024, we searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials for randomised controlled trials, published from database inception, comparing online haemodiafiltration versus haemodialysis designed to measure mortality outcomes. The primary outcome was all-cause mortality. Hazard ratios were generated using Cox proportional hazards regression models reporting hazard ratios and 95% CIs. Subgroup analyses based on predefined patient characteristics and dose–response analyses using natural splines for convection volume were performed. This analysis is registered with PROSPERO (CRD42024511514). Five trials (n=4153 patients; 2070 receiving haemodialysis and 2083 receiving haemodiafiltration) were eligible for inclusion in this analysis. After a median follow-up of 30 months (IQR 24–36), all-cause mortality occurred in 477 patients (23·3%) treated with haemodiafiltration compared with in 559 patients (27·0%) treated with haemodialysis (hazard ratio 0·84 [95% CI 0·74–0·95]). No evidence of a differential effect across subgroups was noted. A graded relationship between convection volume and mortality risk was apparent: as the volume increased, the mortality risk decreased. Compared with haemodialysis, online haemodiafiltration reduces all-cause mortality in people with kidney failure. Results do not differ across patient and treatment characteristics and the risk reduction appears to be dose-dependent. In conclusion, the present analysis strengthens the notion that haemodiafiltration can be considered as a superior alternative to the present standard (ie, haemodialysis). European Commission Research and Innovation, Horizon 2020. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Randomized controlled trials in de-implementation research: a systematic scoping review

Author

Raudasoja, Aleksi J., Falkenbach, Petra, Vernooij, Robin W. M., Mustonen, Jussi M. J., Agarwal, Arnav, Aoki, Yoshitaka, Blanker, Marco H., Cartwright, Rufus, Garcia-Perdomo, Herney A., Kilpeläinen, Tuomas P., Lainiala, Olli, Lamberg, Tiina, Nevalainen, Olli P. O., Raittio, Eero, Richard, Patrick O., Violette, Philippe D., Komulainen, Jorma, Sipilä, Raija, and Tikkinen, Kari A. O.

Published
2022
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15. Polypharmacy in Patients with Chronic Kidney Disease

Author

Oosting, Ilse J., primary, Colombijn, Julia M.T., additional, Kaasenbrood, Lotte, additional, Liabeuf, Sophie, additional, Laville, Solène M., additional, Hooft, Lotty, additional, Bots, Michiel L., additional, Verhaar, Marianne C., additional, and Vernooij, Robin W. M., additional

Published
2024
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16. The general external exposome and the development or progression of chronic kidney disease: a systematic review and meta-analyses

Author

Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Circulatory Health, NVIC bedrijfsvoering, Cardiometabolic Health, Cardiovasculaire Epi Team 7B, MS Nefrologie, Liang, Kate H, Colombijn, Julia M T, Verhaar, Marianne C, Ghannoum, Marc, Timmermans, Erik J, Vernooij, Robin W M, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Circulatory Health, NVIC bedrijfsvoering, Cardiometabolic Health, Cardiovasculaire Epi Team 7B, MS Nefrologie, Liang, Kate H, Colombijn, Julia M T, Verhaar, Marianne C, Ghannoum, Marc, Timmermans, Erik J, and Vernooij, Robin W M

Published
2024

17. The Effect of Artificial Intelligence on Patient-Physician Trust: Cross-Sectional Vignette Study

Author

CDL Upod, Bioethics & Health Humanities, Child Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Rozestraten, Raoul, Grimmelikhuijsen, Stephan G, Jongsma, Karin R, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, CDL Upod, Bioethics & Health Humanities, Child Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Rozestraten, Raoul, Grimmelikhuijsen, Stephan G, Jongsma, Karin R, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, and Haitjema, Saskia

Published
2024

18. Ideal cardiovascular health and cardiovascular related events: a systematic review and meta-analysis

Author

Cardiometabolic Health, Projectafdeling FNE, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 1, Cardiovasculaire Epi Team 7B, MS Nefrologie, Te Hoonte, Femke, Spronk, Merve, Sun, Qi, Wu, Kangrui, Fan, Shiqi, Wang, Ziyi, Bots, Michiel L, Van der Schouw, Yvonne T, Uijl, Alicia, Vernooij, Robin W M, Cardiometabolic Health, Projectafdeling FNE, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 1, Cardiovasculaire Epi Team 7B, MS Nefrologie, Te Hoonte, Femke, Spronk, Merve, Sun, Qi, Wu, Kangrui, Fan, Shiqi, Wang, Ziyi, Bots, Michiel L, Van der Schouw, Yvonne T, Uijl, Alicia, and Vernooij, Robin W M

Published
2024

19. Comparison of the Response to an Electronic Versus a Traditional Informed Consent Procedure in Terms of Clinical Patient Characteristics: Observational Study

Author

CDL Upod, Medical Humanities Onderzoek Team 1, Bioethics & Health Humanities, Child Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Hollestelle, Marieke J, van der Graaf, Rieke, Nathoe, Hendrik M, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, UCC CVRM study group, CDL Upod, Medical Humanities Onderzoek Team 1, Bioethics & Health Humanities, Child Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Team Medisch, Centraal Diagnostisch Laboratorium, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, CDL Cluster Speciële Diagnostiek, Zondag, Anna G M, Hollestelle, Marieke J, van der Graaf, Rieke, Nathoe, Hendrik M, van Solinge, Wouter W, Bots, Michiel L, Vernooij, Robin W M, Haitjema, Saskia, and UCC CVRM study group

Published
2024

20. Polypharmacy in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Author

Nefro Vasculaire Geneeskunde, Unit Opleiding Aios, Epidemiology & Health Economics, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, MS Nefrologie, Oosting, Ilse J, Colombijn, Julia M T, Kaasenbrood, Lotte, Liabeuf, Sophie, Laville, Solène M, Hooft, Lotty, Bots, Michiel L, Verhaar, Marianne C, Vernooij, Robin W M, Nefro Vasculaire Geneeskunde, Unit Opleiding Aios, Epidemiology & Health Economics, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Regenerative Medicine and Stem Cells, MS Nefrologie, Oosting, Ilse J, Colombijn, Julia M T, Kaasenbrood, Lotte, Liabeuf, Sophie, Laville, Solène M, Hooft, Lotty, Bots, Michiel L, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2024

21. Editor's Choice – Prognostic Factors and Models to Predict Mortality Outcomes in Patients with Peripheral Arterial Disease: A Systematic Review

Author

Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Epi Methoden Team 5, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Porras, Cindy P, Teraa, Martin, Damen, Johanna A A, Hazenberg, Constantijn E V B, Bots, Michiel L, Verhaar, Marianne C, Vernooij, Robin W M, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Epi Methoden Team 5, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Porras, Cindy P, Teraa, Martin, Damen, Johanna A A, Hazenberg, Constantijn E V B, Bots, Michiel L, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2024

22. Frequent hemodialysis versus standard hemodialysis for people with kidney failure: Systematic review and meta-analysis of randomized controlled trials

Author

Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Natale, Patrizia, Green, Suetonia C, Rose, Matthias, Bots, Michiel L, Blankestijn, Peter J, Vernooij, Robin W M, Gerittsen, Karin, Woodward, Mark, Hockham, Carinna, Cromm, Krister, Barth, Claudia, Davenport, Andrew, Hegbrant, Jörgen, Sarafidis, Pantelis, Das, Partha, Wanner, Christoph, Nissenson, Allan R, Sautenet, Benedicte, Török, Marietta, Strippoli, Giovanni, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Natale, Patrizia, Green, Suetonia C, Rose, Matthias, Bots, Michiel L, Blankestijn, Peter J, Vernooij, Robin W M, Gerittsen, Karin, Woodward, Mark, Hockham, Carinna, Cromm, Krister, Barth, Claudia, Davenport, Andrew, Hegbrant, Jörgen, Sarafidis, Pantelis, Das, Partha, Wanner, Christoph, Nissenson, Allan R, Sautenet, Benedicte, Török, Marietta, and Strippoli, Giovanni

Published
2024

23. Sex Differences in Mortality Risk after the First Hospitalisation with Lower Extremity Peripheral Arterial Disease

Author

Nefro Vasculaire Geneeskunde, Infection & Immunity, Epi Infectieziekten Team 1, Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P, de Boer, Annemarijn R, Koop, Yvonne, Vaartjes, Ilonca, Teraa, Martin, Hazenberg, Constantijn E V B, Verhaar, Marianne C, Vernooij, Robin W M, Nefro Vasculaire Geneeskunde, Infection & Immunity, Epi Infectieziekten Team 1, Cardiometabolic Health, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, MS Nefrologie, Porras, Cindy P, de Boer, Annemarijn R, Koop, Yvonne, Vaartjes, Ilonca, Teraa, Martin, Hazenberg, Constantijn E V B, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2024

25. Representation of Patients With Chronic Kidney Disease in Clinical Trials of Cardiovascular Disease Medications: A Systematic Review

Author

Nefro Vasculaire Geneeskunde, Team 5a, Epi Methoden Team 5, MS Nefrologie, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, JC onderzoeksprogramma Methodologie, Regenerative Medicine and Stem Cells, Colombijn, Julia M T, Idema, Demy L, van Beem, Sanne, Blokland, Anna Marthe, van der Braak, Kim, Handoko, M Louis, In 't Veld, Linde F Huis, Kaul, Tabea, Kolagasigil-Akdemir, Nurda, Kusters, Mike P T, Meijvis, Sabine C A, Oosting, Ilse J, Spijker, Rene, Bots, Michiel L, Hooft, Lotty, Verhaar, Marianne C, Vernooij, Robin W M, Nefro Vasculaire Geneeskunde, Team 5a, Epi Methoden Team 5, MS Nefrologie, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, JC onderzoeksprogramma Methodologie, Regenerative Medicine and Stem Cells, Colombijn, Julia M T, Idema, Demy L, van Beem, Sanne, Blokland, Anna Marthe, van der Braak, Kim, Handoko, M Louis, In 't Veld, Linde F Huis, Kaul, Tabea, Kolagasigil-Akdemir, Nurda, Kusters, Mike P T, Meijvis, Sabine C A, Oosting, Ilse J, Spijker, Rene, Bots, Michiel L, Hooft, Lotty, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2024

26. Association of mild kidney dysfunction with diastolic dysfunction and heart failure with preserved ejection fraction

Author

MS Nefrologie, Experimentele Afd. Cardiologie 1, Team Medisch, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Onderzoek Vrouw Hart & Vaatziekten, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Vernooij, Robin W M, van Ommen, Anne-Mar L N, Valstar, Gideon B, Cramer, Maarten Jan, Teske, Arco J, Menken, Roxana, Hofstra, Leo, Rutten, Frans H, Bots, Michiel L, den Ruijter, Hester M, Verhaar, Marianne C, MS Nefrologie, Experimentele Afd. Cardiologie 1, Team Medisch, Circulatory Health, HAG Hart- Vaatziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Onderzoek Vrouw Hart & Vaatziekten, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Vernooij, Robin W M, van Ommen, Anne-Mar L N, Valstar, Gideon B, Cramer, Maarten Jan, Teske, Arco J, Menken, Roxana, Hofstra, Leo, Rutten, Frans H, Bots, Michiel L, den Ruijter, Hester M, and Verhaar, Marianne C

Published
2024

27. Frequent hemodialysis versus standard hemodialysis for people with kidney failure: Systematic review and meta-analysis of randomized controlled trials.

Author

Natale, Patrizia, Green, Suetonia C., Rose, Matthias, Bots, Michiel L., Blankestijn, Peter J., Vernooij, Robin W. M., Gerittsen, Karin, Woodward, Mark, Hockham, Carinna, Cromm, Krister, Barth, Claudia, Davenport, Andrew, Hegbrant, Jörgen, Sarafidis, Pantelis, Das, Partha, Wanner, Christoph, Nissenson, Allan R., Sautenet, Benedicte, Török, Marietta, and Strippoli, Giovanni

Subjects
RANDOMIZED controlled trials, QUALITY of life, KIDNEY failure, ARTERIAL catheterization, PATIENT reported outcome measures
Abstract

Background: Frequent hemodialysis provided more than three times per week may lower mortality and improve health-related quality of life. Yet, the evidence is inconclusive. We evaluated the benefits and harms of frequent hemodialysis in people with kidney failure compared with standard hemodialysis. Methods: We performed a systematic review of randomized controlled trials including adults on hemodialysis with highly sensitive searching in MEDLINE, Embase, CENTRAL, and Google Scholar on 3 January 2024. Data were pooled using random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. We adjudicated evidence certainty using GRADE. Results: From 11,142 unique citations, only seven studies involving 518 participants proved eligible. The effects of frequent hemodialysis on physical and mental health were imprecise due to few data. Frequent hemodialysis probably had uncertain effect on death from all cause compared with standard hemodialysis (relative risk 0.79, 95% confidence interval 0.33–1.91, low certainty evidence). Data were not reported for death from cardiovascular causes, major cardiovascular events, fatigue or vascular access. Conclusion: The evidentiary basis for frequent hemodialysis is incomplete due to clinical trials with few or no events reported for mortality and cardiovascular outcome measures and few participants in which patient-reported outcomes including health-related quality of life and symptoms were reported. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Left Ventricular Diastolic Dysfunction across Levels of Kidney Function: A Cross-Sectional Study Based on Routine Clinical Practice Data.

Author

Porras, Cindy P., Dal Canto, Elisa, van Ommen, Anne-Mar L., Handoko, M. Louis, Haitjema, Saskia, de Groot, Mark C. H., Bots, Michiel L., Verhaar, Marianne C., and Vernooij, Robin W. M.

Subjects
LEFT ventricular dysfunction, KIDNEY physiology, GLOMERULAR filtration rate, CAMPUS visits, ECHOCARDIOGRAPHY
Abstract

Left ventricular diastolic dysfunction (LVDD) commonly coexists with kidney dysfunction. In this study, we investigated the presence of abnormalities in echocardiography parameters indicative of LVDD across stages of kidney function. Methods: We selected patients who visited a university hospital and had a serum creatinine and echocardiography reported in their medical records. Participants were categorized based on their kidney function: normal (estimated glomerular filtration rate [eGFR] ≥ 90 mL/min/1.73 m2), mildly decreased (eGFR: 60–90), moderately decreased (eGFR: 30–60), and severely decreased (eGFR < 30). The relationship between kidney function and echocardiography parameters was examined using logistic and linear regressions. Results: Among 4022 patients (age: 66.5 years [SD: 12.1], 41% women), 26%, 50%, 20%, and 4% had a normal, mildly, moderately, and severely decreased kidney function, respectively. Compared to patients with normal kidney function, patients with mildly decreased kidney function had higher odds for an abnormal E/e′ ratio (OR: 1.51 [95% CI: 1.13, 2.02]). Patients with moderately decreased kidney function presented a higher risk of abnormal E/e′ (OR: 2.90 [95% CI: 2.08, 4.04]), LAVI (OR: 1.62 [95% CI: 1.13, 2.33]), TR velocity (OR: 2.31 [95% CI: 1.49, 3.57]), and LVMI (OR: 1.70 [95% CI: 1.31, 2.20]), while patients with severely decreased kidney function had higher odds for abnormal E/e′ (OR: 2.95 [95% CI: 1.68, 5.17]) and LVMI > 95 g/m2 in women or >115 g/m2 in men (OR: 2.07 [95% CI: 1.27, 3.38]). The linear regression showed a significant inverse association between eGFR and echocardiography parameters, meaning that with worse kidney function, the parameters for LVDD worsened as well. Conclusions: Abnormal echocardiography parameters of LVDD were present even in patients with mildly decreased kidney function. As the kidney function worsened, there was a gradual increase in the risk of abnormal parameters of LVDD. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Representation of Patients With Chronic Kidney Disease in Clinical Trials of Cardiovascular Disease Medications

Author

Colombijn, Julia M. T., primary, Idema, Demy L., additional, van Beem, Sanne, additional, Blokland, Anna Marthe, additional, van der Braak, Kim, additional, Handoko, M. Louis, additional, in ’t Veld, Linde F. Huis, additional, Kaul, Tabea, additional, Kolagasigil-Akdemir, Nurda, additional, Kusters, Mike P. T., additional, Meijvis, Sabine C. A., additional, Oosting, Ilse J., additional, Spijker, Rene, additional, Bots, Michiel L., additional, Hooft, Lotty, additional, Verhaar, Marianne C., additional, and Vernooij, Robin W. M., additional

Published
2024
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32. Association of mild kidney dysfunction with diastolic dysfunction and heart failure with preserved ejection fraction

Author

Vernooij, Robin W. M., primary, van Ommen, Anne‐Mar L. N., additional, Valstar, Gideon B., additional, Cramer, Maarten Jan, additional, Teske, Arco J., additional, Menken, Roxana, additional, Hofstra, Leo, additional, Rutten, Frans H., additional, Bots, Michiel L., additional, den Ruijter, Hester M., additional, and Verhaar, Marianne C., additional

Published
2023
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33. Respiratory and Cardiovascular Health Effects of e-Cigarette Substitution: Protocol for Two Living Systematic Reviews

Author

O'Leary, Renee, Qureshi, Maria Ahmed, La Rosa, Giusy Rita Maria, Vernooij, Robin W M, Odimegwu, Damian Chukwu, Bertino, Gaetano, and Polosa, Riccardo

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundDespite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and cardiovascular effects, have come to differing conclusions. ObjectiveWe conducted two systematic reviews to critically assess and synthesize available human studies on the respiratory and cardiovascular health effects of ENDS substitution for people who smoke. The primary goal is to provide clinicians with evidence on the health effects of ENDS substitution to inform their treatment recommendations and plans. The twin goal of the reviews is to promote health literacy in ENDS users with facts on the health effects of ENDS. MethodsThese two reviews will be living systematic reviews. The systematic reviews will be initiated through a baseline review. Studies will be evaluated using the JBI quality assessment tools and a checklist of biases drawn from the Centre for Evidence Based Medicine Catalogue of Bias. A narrative synthesis is planned because of the heterogeneity of data. A search for recently published studies will be conducted every 3 months, and an updated review will be published every 6 months for the duration of the project or possibly longer. ResultsThe baseline and updated reviews will be published in a peer-reviewed journal. The findings of the reviews will be reported in a white paper for clinicians and a fact sheet for people who use ENDS. ConclusionsThe substitution of ENDS for cigarettes is one way to potentially reduce the risks of smoking. Clinicians and their patients need to understand the potential benefits and possible risks of substituting ENDS for cigarettes. Our living systematic reviews seek to highlight the best and most up-to-date evidence in this highly contentious and fast-moving field of research. Trial RegistrationPROSPERO CRD42021239094; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=239094 International Registered Report Identifier (IRRID)DERR1-10.2196/29084

Published
2021
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39. Risk of kidney and liver diseases after COVID‐19 infection: A systematic review and meta‐analysis.

Author

Pan, Bei, Wang, Xiaoman, Lai, Honghao, Vernooij, Robin W. M., Deng, Xiyuan, Ma, Ning, Li, Dan, Huang, Jiajie, Zhao, Weilong, Ning, Jinling, Liu, Jianing, Tian, Jinhui, Ge, Long, and Yang, Kehu

Abstract

COVID‐19 is not only associated with substantial acute liver and kidney injuries, but also with an elevated risk of post‐acute sequelae involving the kidney and liver system. We aimed to investigate whether COVID‐19 exposure increases the long‐term risk of kidney and liver disease, and what are the magnitudes of these associations. We searched PubMed, Embase, Web of Science, ClinicalTrials.gov, and the Living Overview of the Evidence COVID‐19 Repository for cohort studies estimating the association between COVID‐19 and kidney and liver outcomes. Random‐effects meta‐analyses were performed to combine the results of the included studies. We assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID‐19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The absolute increases due to COVID‐19 for acute kidney injury, chronic kidney disease, and liver test abnormality were 3, 8, and 3 per 1000 persons, respectively. Subgroup analyses found no differences between different type of kidney and liver diseases. The findings provide further evidence for the association between COVID‐19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID‐19 on kidney and liver outcomes was, however, relatively small. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Association of mild kidney dysfunction with diastolic dysfunction and heart failure with preserved ejection fraction.

Author

Vernooij, Robin W. M., van Ommen, Anne‐Mar L. N., Valstar, Gideon B., Cramer, Maarten Jan, Teske, Arco J., Menken, Roxana, Hofstra, Leo, Rutten, Frans H., Bots, Michiel L., den Ruijter, Hester M., and Verhaar, Marianne C.

Subjects
LEFT ventricular dysfunction, HEART failure, VENTRICULAR ejection fraction, VENTRICULAR dysfunction, KIDNEYS
Abstract

Aims: We aim to investigate the association between kidney dysfunction and left ventricular diastolic dysfunction parameters and heart failure with preserved ejection fraction (HFpEF) and whether this is sex‐specific. Methods and results: We included participants from the HELPFul observational study. Outpatient clinical care data, including echocardiography, and an expert panel judgement on HFpEF was collected. Estimated glomerular filtration rate (eGFR) was calculated by creatinine and cystatin C without race. The association between eGFR with E/e′, left ventricular mass index, relative wall thickness, and stage C/D heart failure was tested by multivariable adjusted regression models, stratified by sex, reporting odds ratios and 95% confidence intervals (95% confidence interval). We analysed 880 participants, mean age 62.9 (standard deviation: 9.3) years, 69% female. Four hundred six participants had mild (37.6%) kidney dysfunction (eGFR: 60–89 mL/min/1.73 m2) or moderate (8.5%) kidney dysfunction (eGFR: 30–59 mL/min/1.73 m2). HFpEF was significantly more prevalent in participants with mild and moderate kidney dysfunction (10.3% and 16.0%, respectively) than participants with normal kidney function (3.4%). A lower kidney function was associated with higher E/e′ and higher relative wall thickness values. Participants with moderate kidney dysfunction had a higher likelihood of American College of Cardiology/American Heart Association stage C/D HF (odds ratio: 2.07, 95% confidence interval: 1.23, 3.49) than participants with normal kidney functions. Conclusions: Both mild and moderate kidney dysfunction are independently associated with left ventricular diastolic dysfunction parameters and HFpEF. This association is independent of sex and strongest for moderate kidney dysfunction. Considering mild‐to‐moderate kidney dysfunction as risk factor for HFpEF may help identify high‐risk groups benefiting most from early intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review

Author

Ahmed, Sabbir, Vries, Joost C. de, Lu, Jingyi, Stuart, Milan H. Verrijn, Mihăilă, Silvia M., Vernooij, Robin W. M., Masereeuw, Rosalinde, Gerritsen, Karin G. F., Ahmed, Sabbir, Vries, Joost C. de, Lu, Jingyi, Stuart, Milan H. Verrijn, Mihăilă, Silvia M., Vernooij, Robin W. M., Masereeuw, Rosalinde, and Gerritsen, Karin G. F.

Abstract

Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding. Therefore, novel approaches are being developed, but these require validation in animals before clinical trials can begin. We conducted a systematic review to document PBUT concentrations in various models and species. The search strategy returned 1163 results for which abstracts were screened, resulting in 65 full-text papers for data extraction (rats (n = 41), mice (n = 17), dogs (n = 3), cats (n = 4), goats (n = 1), and pigs (n = 1)). We performed descriptive and comparative analyses on indoxyl sulfate (IS) concentrations in rats and mice. The data on large animals and on other PBUTs were too heterogeneous for pooled analysis. Most rodent studies reported mean uremic concentrations of plasma IS close to or within the range of those during kidney failure in humans, with the highest in tubular injury models in rats. Compared to nephron loss models in rats, a greater rise in plasma IS compared to creatinine was found in tubular injury models, suggesting tubular secretion was more affected than glomerular filtration. In summary, tubular injury rat models may be most relevant for the in vivo validation of novel PBUT-lowering strategies for kidney failure in humans.

Published
2023

43. Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review

Author

Afd Pharmacology, Pharmacology, Ahmed, Sabbir, Vries, Joost C. de, Lu, Jingyi, Stuart, Milan H. Verrijn, Mihăilă, Silvia M., Vernooij, Robin W. M., Masereeuw, Rosalinde, Gerritsen, Karin G. F., Afd Pharmacology, Pharmacology, Ahmed, Sabbir, Vries, Joost C. de, Lu, Jingyi, Stuart, Milan H. Verrijn, Mihăilă, Silvia M., Vernooij, Robin W. M., Masereeuw, Rosalinde, and Gerritsen, Karin G. F.

Published
2023

44. Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines

Author

Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Johnston, Bradley C., Zeraatkar, Dena, Steen, Jeremy, Rada Fernandez de Jauregui, Diego, Zhu, Hongfei, Cooper, Matthew, Maraj, Malgorzata, Prokop-Dorner, Anna, Castro Reyes, Boris, Valli, Claudia, Storman, Dawid, Karam, Giorgio, Zajac, Joanna, Ge, Long, Swierz, Mateusz J., Ghosh, Nirjhar, Vernooij, Robin W. M., Chang, Yaping, Zhao, Yunli, Thabane, Lehana, Guyatt, Gordon H., Alonso Coello, Pablo, Hooper, Lee, Bala, Malgorzata M., Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Johnston, Bradley C., Zeraatkar, Dena, Steen, Jeremy, Rada Fernandez de Jauregui, Diego, Zhu, Hongfei, Cooper, Matthew, Maraj, Malgorzata, Prokop-Dorner, Anna, Castro Reyes, Boris, Valli, Claudia, Storman, Dawid, Karam, Giorgio, Zajac, Joanna, Ge, Long, Swierz, Mateusz J., Ghosh, Nirjhar, Vernooij, Robin W. M., Chang, Yaping, Zhao, Yunli, Thabane, Lehana, Guyatt, Gordon H., Alonso Coello, Pablo, Hooper, Lee, and Bala, Malgorzata M.

Abstract

BACKGROUND: The health effects of dietary fats are a controversial issue on which experts and authoritative organizations have often disagreed. Care providers, guideline developers, policy-makers, and researchers use systematic reviews to advise patients and members of the public on optimal dietary habits, and to formulate public health recommendations and policies. Existing reviews, however, have serious limitations that impede optimal dietary fat recommendations, such as a lack of focus on outcomes important to people, substantial risk of bias (RoB) issues, ignoring absolute estimates of effects together with comprehensive assessments of the certainty of the estimates for all outcomes. OBJECTIVE: We therefore propose a methodologically innovative systematic review using direct and indirect evidence on diet and food-based fats (i.e., reduction or replacement of saturated fat with monounsaturated or polyunsaturated fat, or carbohydrates or protein) and the risk of important health outcomes. METHODS: We will collaborate with an experienced research librarian to search MEDLINE, EMBASE, CINAHL, and the Cochrane Database of Systematic Reviews (CDSR) for randomized clinical trials (RCTs) addressing saturated fat and our health outcomes of interest. In duplicate, we will screen, extract results from primary studies, assess their RoB, conduct de novo meta-analyses and/or network meta-analysis, assess the impact of missing outcome data on meta-analyses, present absolute effect estimates, and assess the certainty of evidence for each outcome using the GRADE contextualized approach. Our work will inform recommendations on saturated fat based on international standards for reporting systematic reviews and guidelines. CONCLUSION: Our systematic review and meta-analysis will provide the most comprehensive and rigorous summary of the evidence addressing the relationship between saturated fat modification for people-important health outcomes. The evidence from this review will be

Published
2023

45. Discovering Distinct Phenotypical Clusters in Heart Failure Across the Ejection Fraction Spectrum: a Systematic Review

Author

Cardiovasculaire Epi Team 7B, MS Nefrologie, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Global Public Health & Bioethics, Meijs, Claartje, Handoko, M Louis, Savarese, Gianluigi, Vernooij, Robin W M, Vaartjes, Ilonca, Banerjee, Amitava, Koudstaal, Stefan, Brugts, Jasper J, Asselbergs, Folkert W, Uijl, Alicia, Cardiovasculaire Epi Team 7B, MS Nefrologie, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Global Public Health & Bioethics, Meijs, Claartje, Handoko, M Louis, Savarese, Gianluigi, Vernooij, Robin W M, Vaartjes, Ilonca, Banerjee, Amitava, Koudstaal, Stefan, Brugts, Jasper J, Asselbergs, Folkert W, and Uijl, Alicia

Published
2023

46. A systematic review of kidney-on-a-chip-based models to study human renal (patho-)physiology

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Nguyen, Vivian V T, Gkouzioti, Vasiliki, Maass, Christian, Verhaar, Marianne C, Vernooij, Robin W M, van Balkom, Bas W M, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, Nguyen, Vivian V T, Gkouzioti, Vasiliki, Maass, Christian, Verhaar, Marianne C, Vernooij, Robin W M, and van Balkom, Bas W M

Published
2023

47. One heartbeat away from a prediction model for cardiovascular diseases in patients with chronic kidney disease: a systematic review

Author

Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, Epi Methoden Team 5, MS Nefrologie, Regenerative Medicine and Stem Cells, Smit, Leanne Cm, Bots, Michiel L, van der Leeuw, Joep, Damen, Johanna AA, Blankestijn, Peter J, Verhaar, Marianne C, Vernooij, Robin W M, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Nefro Vasculaire Geneeskunde, Epi Methoden Team 5, MS Nefrologie, Regenerative Medicine and Stem Cells, Smit, Leanne Cm, Bots, Michiel L, van der Leeuw, Joep, Damen, Johanna AA, Blankestijn, Peter J, Verhaar, Marianne C, and Vernooij, Robin W M

Published
2023

50. Timing of symptomatic venous thromboembolism after surgery: meta-analysis

Author

Singh, Tino, primary, Lavikainen, Lauri I, additional, Halme, Alex L E, additional, Aaltonen, Riikka, additional, Agarwal, Arnav, additional, Blanker, Marco H, additional, Bolsunovskyi, Kostiantyn, additional, Cartwright, Rufus, additional, García-Perdomo, Herney, additional, Gutschon, Rachel, additional, Lee, Yung, additional, Pourjamal, Negar, additional, Vernooij, Robin W M, additional, Violette, Philippe D, additional, Haukka, Jari, additional, Guyatt, Gordon H, additional, and Tikkinen, Kari A O, additional

Published
2023
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