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At the end of 2021, the ESO council approved the start of the construction phase for a High Resolution Spectrograph for the ELT, formerly known as ELT-HIRES, renamed recently as ANDES (ArmazoNes high Dispersion Echelle Spectrograph). The current initial schedule foresees a 9-years development aimed to bring the instrument on-sky soon after the first-generation ELT instruments. ANDES combines high spectral resolution (up to 100,000), wide spectral range (0.4 mu m to 1.8 mu m with a goal from 0.35 mu m to 2.4 mu m) and extreme stability in wavelength calibration accuracy (better than 0.02 m/s rms over a 10-year period in a selected wavelength range) with massive optical collecting power of the ELT thus enabling to achieve possible breakthrough groundbreaking scientific discoveries. The main science cases cover a possible detection of life signatures in exoplanets, the study of the stability of Nature's physical constants along the universe lifetime and a first direct measurement of the cosmic acceleration. The reference design of this instrument in its extended version (with goals included) foresees 4 spectrographic modules fed by fibers, operating in seeing and diffraction limited (adaptive optics assisted) mode carried out by an international consortium composed by 24 institutes from 13 countries which poses big challenges in several areas.In this paper we will describe the approach we intend to pursue to master management and system engineering aspects of this challenging instrument focused mainly on the preliminary design phase, but looking also ahead towards its final construction.

BACKGROUND: Overweight and obesity are highly prevalent conditions associated with premature morbidity and mortality worldwide. Capsiate, a nonpungent analogue of capsaicin, binds to capsaicin binds to TRP vanilloid 1 (TRPV1) receptor, which is involved in adipogenesis, and could be effective as a weight-lowering agent. METHODS AND RESULTS: Eighteen slightly overweight women were enrolled in this randomized, doble-blind, placebo-controlled study. Nine patients were included in the capsiate intervention group and received 9 mg/day of capsinoids whereas other 9 patients received placebo for 8 weeks. All patients underwent weight and waist circumference assessment before and after treatment. Body composition and bone mineral density were also detected by Dual-energy X-ray absorptiometry (DXA). Fourteen patients completed the study. The treatment with capsiate or placebo for 8 weeks was not associated to significant changes in weight or waist circumference. After treatment, there was a significant improvement of Bone Mineral density (BMD values measured at the spine in the capsiate group (1.158 vs 1.106 g/cm2, +4.7%; p = 0.04), but not in the group treated with placebo. Similarly, the capsiate group showed a 9.1% increase (p = 0.05) in the adipose tissue and an 8.5% decrease in lean mass measured at the supraclavicular level, whereas these changes were not statistically significant in the placebo group.CONCLUSION: Treatment with capsiate for 8 weeks led to negligible changes in body weight in a small sample of slightly overweight women, but our findings suggest a potential effect of capsaicin on bone metabolism in humans.

We present the baseline conceptual design of the Cassegrain U-Band Efficient Spectrograph (CUBES) for the Very Large Telescope. CUBES will provide unprecedented sensitivity for spectroscopy on a 8 - 10 m class telescope in the ground ultraviolet (UV), spanning a bandwidth of > 100 nm that starts at 300 nm, the shortest wavelength accessible from the ground. The design has been optimized for end-to-end efficiency and provides a spectral resolving power of R > 20000, that will unlock a broad range of new topics across solar system, Galactic and extraglactic astronomy. The design also features a second, lower-resolution (R \sim 7000) mode and has the option of a fiberlink to the UVES instrument for simultaneous observations at longer wavelengths. Here we present the optical, mechanical and software design of the various subsystems of the instrument after the Phase A study of the project. We discuss the expected performances for the layout choices and highlight some of the performance trade-offs considered to best meet the instrument top-level requirements. We also introduce the model-based system engineering approach used to organize and manage the project activities and interfaces, in the context that it is increasingly necessary to integrate such tools in the development of complex astronomical projects., Accepted for publication in Experimental Astronomy

The strong intervening absorption system at redshift 1.15 towards the very bright quasar HE 0515$-$4414 is the most studied absorber for measuring possible cosmological variations in the fine-structure constant, $\alpha$. We observed HE 0515$-$4414 for 16.1$\,$h with the Very Large Telescope and present here the first constraint on relative variations in $\alpha$ with parts-per-million (ppm) precision from the new ESPRESSO spectrograph: $\Delta\alpha/\alpha = 1.3 \pm 1.3_{\rm stat} \pm 0.4_{\rm sys}\,{\rm ppm}$. The statistical uncertainty (1$\sigma$) is similar to the ensemble precision of previous large samples of absorbers, and derives from the high S/N achieved ($\approx$105 per 0.4$\,$km$\,$s$^{-1}$ pixel). ESPRESSO's design, and calibration of our observations with its laser frequency comb, effectively removed wavelength calibration errors from our measurement. The high resolving power of our ESPRESSO spectrum ($R=145000$) enabled the identification of very narrow components within the absorption profile, allowing a more robust analysis of $\Delta\alpha/\alpha$. The evidence for the narrow components is corroborated by their correspondence with previously detected molecular hydrogen and neutral carbon. The main remaining systematic errors arise from ambiguities in the absorption profile modelling, effects from redispersing the individual quasar exposures, and convergence of the parameter estimation algorithm. All analyses of the spectrum, including systematic error estimates, were initially blinded to avoid human biases. We make our reduced ESPRESSO spectrum of HE 0515$-$4414 publicly available for further analysis. Combining our ESPRESSO result with 28 measurements, from other spectrographs, in which wavelength calibration errors have been mitigated, yields a weighted mean $\Delta\alpha/\alpha = -0.5 \pm 0.5_{\rm stat} \pm 0.4_{\rm sys}\,$ppm at redshifts 0.6-2.4., Comment: Accepted by A&A. The ESPRESSO quasar spectrum, reduced contributing exposures, and absorption profile fits are available at https://github.com/MTMurphy77/ESPRESSO_HE0515-4414