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4. Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids

Author

Cioce, Mario, Fumagalli, Maria Rita, Donzelli, Sara, Goeman, Frauke, Canu, Valeria, Rutigliano, Daniela, Orlandi, Giulia, Sacconi, Andrea, Pulito, Claudio, Palcau, Alina Catalina, Fanciulli, Maurizio, Morrone, Aldo, Diodoro, Maria Grazia, Caricato, Marco, Crescenzi, Anna, Verri, Martina, Fazio, Vito Michele, Zapperi, Stefano, Levrero, Massimo, Strano, Sabrina, Grazi, Gian Luca, La Porta, Caterina, and Blandino, Giovanni

Published
2023
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6. Lipocalin-2 promotes adipose–macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune encephalomyelitis

Author

Sciarretta, Francesca, Ceci, Veronica, Tiberi, Marta, Zaccaria, Fabio, Li, Haoyun, Zhou, Zhong-Yan, Sun, Qiyang, Konja, Daniels, Matteocci, Alessandro, Bhusal, Anup, Verri, Martina, Fresegna, Diego, Balletta, Sara, Ninni, Andrea, Di Biagio, Claudia, Rosina, Marco, Suk, Kyoungho, Centonze, Diego, Wang, Yu, Chiurchiù, Valerio, Aquilano, Katia, and Lettieri-Barbato, Daniele

Published
2023
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7. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

Author

Rosina, Marco, Ceci, Veronica, Turchi, Riccardo, Li, Chuan, Borcherding, Nicholas, Sciarretta, Francesca, Sánchez-Díaz, María, Tortolici, Flavia, Karlinsey, Keaton, Chiurchiù, Valerio, Fuoco, Claudia, Giwa, Rocky, Field, Rachael L., Audano, Matteo, Arena, Simona, Palma, Alessandro, Riccio, Federica, Shamsi, Farnaz, Renzone, Giovanni, Verri, Martina, Crescenzi, Anna, Rizza, Salvatore, Faienza, Fiorella, Filomeni, Giuseppe, Kooijman, Sander, Rufini, Stefano, de Vries, Antoine A.F., Scaloni, Andrea, Mitro, Nico, Tseng, Yu-Hua, Hidalgo, Andrés, Zhou, Beiyan, Brestoff, Jonathan R., Aquilano, Katia, and Lettieri-Barbato, Daniele

Published
2022
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9. T Cell Ig and ITIM Domains (TIGIT) Expression in Multiple Myeloma

Author

Annibali, Ombretta, primary, Di Cecca, Monica, additional, Verri, Martina, additional, Tafuri, Mariantonietta, additional, Bianchi, Antonella, additional, Schiaroli, Paolo, additional, Tomarchio, Valeria, additional, Crescenzi, Anna, additional, Avvisati, Giuseppe, additional, and Rigacci, Luigi, additional

Published
2023
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14. Thyroid cancer diagnosis by Raman spectroscopy

Author

Sbroscia, Marco, Di Gioacchino, Michael, Ascenzi, Paolo, Crucitti, Pierfilippo, di Masi, Alessandra, Giovannoni, Isabella, Longo, Filippo, Mariotti, Davide, Naciu, Anda Mihaela, Palermo, Andrea, Taffon, Chiara, Verri, Martina, Sodo, Armida, Crescenzi, Anna, and Ricci, Maria Antonietta

Published
2020
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15. Real-Time Urethral and Ureteral Assessment during Radical Cystectomy Using Ex-Vivo Optical Imaging: A Novel Technique for the Evaluation of Fresh Unfixed Surgical Margins

Author

Prata, Francesco, primary, Anceschi, Umberto, additional, Taffon, Chiara, additional, Rossi, Silvia Maria, additional, Verri, Martina, additional, Iannuzzi, Andrea, additional, Ragusa, Alberto, additional, Esperto, Francesco, additional, Prata, Salvatore Mario, additional, Crescenzi, Anna, additional, Scarpa, Roberto Mario, additional, Simone, Giuseppe, additional, and Papalia, Rocco, additional

Published
2023
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16. New digital confocal laser microscopy may boost real-time evaluation of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) from solid pancreatic lesions: Data from an international multicenter study

Author

Amendoeira, Isabel, primary, Arcidiacono, Paolo Giorgio, additional, Barizzi, Jessica, additional, Capitanio, Arrigo, additional, Cuatrecasas, Miriam, additional, Di Matteo, Francesco Maria, additional, Doglioni, Claudio, additional, Fukushima, Noriyoshi, additional, Fulciniti, Franco, additional, Ginès, Angels, additional, Giovannini, Marc, additional, Zaibo, Li, additional, Lopes, Joanne, additional, Lujan, Giovanni, additional, Parisi, Alice, additional, Poizat, Flora, additional, Reggiani Bonetti, Luca, additional, Stigliano, Serena, additional, Taffon, Chiara, additional, Verri, Martina, additional, and Crescenzi, Anna, additional

Published
2022
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17. Additional file 1 of Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids

Author

Cioce, Mario, Fumagalli, Maria Rita, Donzelli, Sara, Goeman, Frauke, Canu, Valeria, Rutigliano, Daniela, Orlandi, Giulia, Sacconi, Andrea, Pulito, Claudio, Palcau, Alina Catalina, Fanciulli, Maurizio, Morrone, Aldo, Diodoro, Maria Grazia, Caricato, Marco, Crescenzi, Anna, Verri, Martina, Fazio, Vito Michele, Zapperi, Stefano, Levrero, Massimo, Strano, Sabrina, Grazi, Gian Luca, La Porta, Caterina, and Blandino, Giovanni

Abstract

Additional file 1.

Published
2023
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18. PSAT379 Performance of a Raman Fingerprint in Thyroid Nodules with Indeterminate Cytology: A Prospective Blinded Monocentric Study

Author

Palermo, Andrea, primary, Sodo, Armida, additional, Naciu, Anda Mihaela, additional, Gioacchino, Michael D, additional, Paolucci, Alessio, additional, Masi, Alessandra D, additional, Maggi, Daria, additional, Crucitti, Pierfilippo, additional, Longo, Filippo, additional, Perrella, Eleonora, additional, Taffon, Chiara, additional, Verri, Martina, additional, Ricci, Maria Antonietta, additional, and Crescenzi, Anna, additional

Published
2022
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19. Clinical Use of Raman Spectroscopy Improves Diagnostic Accuracy for Indeterminate Thyroid Nodules

Author

Palermo, Andrea, primary, Sodo, Armida, additional, Naciu, Anda Mihaela, additional, Di Gioacchino, Michael, additional, Paolucci, Alessio, additional, di Masi, Alessandra, additional, Maggi, Daria, additional, Crucitti, Pierfilippo, additional, Longo, Filippo, additional, Perrella, Eleonora, additional, Taffon, Chiara, additional, Verri, Martina, additional, Ricci, Maria Antonietta, additional, and Crescenzi, Anna, additional

Published
2022
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20. Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma

Author

di Masi, Alessandra, primary, Sessa, Rosario Luigi, additional, Cerrato, Ylenia, additional, Pastore, Gianni, additional, Guantario, Barbara, additional, Ambra, Roberto, additional, Di Gioacchino, Michael, additional, Sodo, Armida, additional, Verri, Martina, additional, Crucitti, Pierfilippo, additional, Longo, Filippo, additional, Naciu, Anda Mihaela, additional, Palermo, Andrea, additional, Taffon, Chiara, additional, Acconcia, Filippo, additional, Bianchi, Fabrizio, additional, Ascenzi, Paolo, additional, Ricci, Maria Antonietta, additional, and Crescenzi, Anna, additional

Published
2022
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21. New digital confocal laser microscopy may boost real-time evaluation of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) from solid pancreatic lesions: Data from an international multicenter study

Author

Amendoeira, Isabel, Arcidiacono, Paolo Giorgio, Barizzi, Jessica, Capitanio, Arrigo, Cuatrecasas, Miriam, Matteo, Francesco Maria Di, Doglioni, Claudio, Fukushima, Noriyoshi, Fulciniti, Franco, Gines, Angels, Giovannini, Marc, Zaibo, Li, Lopes, Joanne, Lujan, Giovanni, Parisi, Alice, Poizat, Flora, Bonetti, Luca Reggiani, Stigliano, Serena, Taffon, Chiara, Verri, Martina, Crescenzi, Anna, Amendoeira, Isabel, Arcidiacono, Paolo Giorgio, Barizzi, Jessica, Capitanio, Arrigo, Cuatrecasas, Miriam, Matteo, Francesco Maria Di, Doglioni, Claudio, Fukushima, Noriyoshi, Fulciniti, Franco, Gines, Angels, Giovannini, Marc, Zaibo, Li, Lopes, Joanne, Lujan, Giovanni, Parisi, Alice, Poizat, Flora, Bonetti, Luca Reggiani, Stigliano, Serena, Taffon, Chiara, Verri, Martina, and Crescenzi, Anna

Abstract

Background Pancreatic cancer is an aggressive malignancy and a leading cause of cancer death worldwide; its lethality is partly linked to the difficulty of early diagnosis. Modern devices for endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) were recently developed to improve targeting and sampling of small lesions, but innovative technologies for microscopic assessment are still lacking. Ex vivo fluorescence confocal laser microscopy (FCM) is a new digital tool for real-time microscopic assessment of fresh unfixed biological specimens, avoiding conventional histological slide preparation and potentially being highly appealing for EUS-FNB specimens. Methods This study evaluated the possible role of FCM for immediate evaluation of pancreatic specimens from EUS-FNB. It involved comparison of the interobserver agreement between the new method and standard histological analysis during international multicenter sharing of digital images. Digital images from 25 cases of EUS-FNB obtained with real-time FCM technology and 25 paired digital whole-slide images from permanent conventional paraffin sections were observed by 10 pathologists from different Institutions in Europe, Japan, and the United States, in a blinded manner. The study evaluated 500 observations regarding adequacy, morphological clues, diagnostic categories, and final diagnosis. Findings Statistical analysis showed substantial equivalence in the interobserver agreement among pathologists using the two techniques. There was also good inter-test agreement in determining sample adequacy and when assigning a diagnostic category. Among morphological features, nuclear enlargement was the most reproducible clue, with very good inter-test agreement. Interpretation Findings in this study are from international multicenter digital sharing and are published here for the first time. Considering the advantages of FCM digital diagnostics in terms of reduced time and unaltered sample maintenance, the ex vivo confoca

Published
2022
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22. Performance of a raman fingerprint in thyroid nodules with indeterminate cytology: a prospective blinded monocentric study

Author

Palermo, Andrea, primary, Sodo, Armida, additional, Mihaela, Naciu Anda, additional, Di, Gioacchino Michael, additional, Paolucci, Alessio, additional, Di, Masi Alessandra, additional, Maggi, Daria, additional, Crucitti, Pierfilippo, additional, Longo, Filippo, additional, Perrella, Eleonora, additional, Taffon, Chiara, additional, Verri, Martina, additional, Antonietta, Ricci Maria, additional, and Crescenzi, Anna, additional

Published
2022
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28. Raman Spectroscopy Discloses Altered Molecular Profile in Thyroid Adenomas

Author

Sodo, Armida, primary, Verri, Martina, additional, Palermo, Andrea, additional, Naciu, Anda Mihaela, additional, Sponziello, Marialuisa, additional, Durante, Cosimo, additional, Di Gioacchino, Michael, additional, Paolucci, Alessio, additional, di Masi, Alessandra, additional, Longo, Filippo, additional, Crucitti, Pierfilippo, additional, Taffon, Chiara, additional, Ricci, Maria Antonietta, additional, and Crescenzi, Anna, additional

Published
2020
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30. Raman Spectroscopy Discloses Altered Molecular Profile in Thyroid Adenomas.

Author

Sodo, Armida, Verri, Martina, Palermo, Andrea, Naciu, Anda Mihaela, Sponziello, Marialuisa, Durante, Cosimo, Di Gioacchino, Michael, Paolucci, Alessio, di Masi, Alessandra, Longo, Filippo, Crucitti, Pierfilippo, Taffon, Chiara, Ricci, Maria Antonietta, and Crescenzi, Anna

Subjects
*RAMAN spectroscopy, *BENIGN tumors, *THYROID nodules, *PROTEIN expression, *CANCER invasiveness
Abstract

Follicular patterned nodules are sometimes complex to be classified due to ambiguous nuclear features and/or questionable capsular or vascular invasion. In this setting, there is a poor inter-observer concordance even among expert pathologists. Raman spectroscopy was recently used to separate benign and malignant thyroid nodules based on their molecular fingerprint; anyway, some histologically proved follicular adenomas were clustered as having a characteristic profile of malignant lesions. In this study, we analyzed five follicular thyroid adenomas with a malignant spectroscopic profile compared to five follicular adenomas with a benign Raman spectrum in order to assess possible molecular differences between the two groups. Morphological, immunohistochemical, and molecular analyses evidenced expression of malignancy-associated proteins in four out of five malignant clustered adenomas. The remaining malignant clustered adenoma showed a TSHR mutation previously associated with autonomously functioning follicular carcinomas. In conclusion, thyroid follicular adenomas are a group of morphologically benign neoplasms that may have altered the mutational or expression profile; cases of adenomas with altered immunophenotype are recognized as showing a profile associated with malignancy by Raman spectroscopy. This correlation warrants a more extensive evaluation and suggests a potential predictive value of spectroscopic assessment in recognizing characteristics associated with tumor progression in follicular thyroid neoplasms. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma

Author

Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, Filippo Longo, Anda Mihaela Naciu, Andrea Palermo, Chiara Taffon, Filippo Acconcia, Fabrizio Bianchi, Paolo Ascenzi, Maria Antonietta Ricci, Anna Crescenzi, di Masi, Alessandra, Sessa, Rosario Luigi, Cerrato, Ylenia, Pastore, Gianni, Guantario, Barbara, Ambra, Roberto, Di Gioacchino, Michael, Sodo, Armida, Verri, Martina, Crucitti, Pierfilippo, Longo, Filippo, Naciu, Anda Mihaela, Palermo, Andrea, Taffon, Chiara, Acconcia, Filippo, Bianchi, Fabrizio, Ascenzi, Paolo, Ricci, Maria Antonietta, and Crescenzi, Anna

Subjects
antioxidant, Physiology, Clinical Biochemistry, retinoic acid, papillary thyroid cancer, Cell Biology, carotenoid, Molecular Biology, Biochemistry
Abstract

Among the thyroid cancers, papillary thyroid cancer (PTC) accounts for 90% of the cases. In addition to the necessity to identify new targets for PTC treatment, early diagnosis and management are highly demanded. Previous data indicated that the multivariate statistical analysis of the Raman spectra allows the discrimination of healthy tissues from PTC ones; this is characterized by bands typical of carotenoids. Here, we dissected the molecular effects of carotenoid accumulation in PTC patients by analyzing whether they were required to provide increased retinoic acid (RA) synthesis and signaling and/or to sustain antioxidant functions. HPLC analysis revealed the lack of a significant difference in the overall content of carotenoids. For this reason, we wondered whether the carotenoid accumulation in PTC patients could be related to vitamin A derivative retinoic acid (RA) biosynthesis and, consequently, the RA-related pathway activation. The transcriptomic analysis performed using a dedicated PCR array revealed a significant downregulation of RA-related pathways in PTCs, suggesting that the carotenoid accumulation in PTC could be related to a lower metabolic conversion into RA compared to that of healthy tissues. In addition, the gene expression profile of 474 PTC cases previously published in the framework of the Cancer Genome Atlas (TGCA) project was examined by hierarchical clustering and heatmap analyses. This metanalysis study indicated that the RA-related pathways resulted in being significantly downregulated in PTCs and being associated with the follicular variant of PTC (FV-PTC). To assess whether the possible fate of the carotenoids accumulated in PTCs is associated with the oxidative stress response, the expression of enzymes involved in ROS scavenging was checked. An increased oxidative stress status and a reduced antioxidant defense response were observed in PTCs compared to matched healthy thyroids; this was possibly associated with the prooxidant effects of high levels of carotenoids. Finally, the DepMap datasets were used to profile the levels of 225 metabolites in 12 thyroid cancer cell lines. The results obtained suggested that the high carotenoid content in PTCs correlates with tryptophan metabolism. This pilot provided novel possible markers and possible therapeutic targets for PTC diagnosis and therapy. For the future, a larger study including a higher number of PTC patients will be necessary to further validate the molecular data reported here.

Published
2022

32. Thyroid cancer diagnosis by Raman spectroscopy

Author

Armida Sodo, Alessandra di Masi, Marco Sbroscia, Michael Di Gioacchino, Martina Verri, Chiara Taffon, Davide Mariotti, Paolo Ascenzi, Anda Mihaela Naciu, Pierfilippo Crucitti, Anna Crescenzi, Andrea Palermo, Maria Antonietta Ricci, Filippo Longo, Isabella Giovannoni, Sbroscia, Marco, Di Gioacchino, Michael, Ascenzi, Paolo, Crucitti, Pierfilippo, di Masi, Alessandra, Giovannoni, Isabella, Longo, Filippo, Mariotti, Davide, Naciu, Anda Mihaela, Palermo, Andrea, Taffon, Chiara, Verri, Martina, Sodo, Armida, Crescenzi, Anna, and Ricci, Maria Antonietta

Subjects
Adenoma, Male, 0301 basic medicine, medicine.medical_specialty, Biopsy, Fine-Needle, Biophysics, Thyroid Gland, lcsh:Medicine, Spectrum Analysis, Raman, Malignancy, Article, Diagnosis, Differential, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Biopsy, medicine, Humans, Thyroid Neoplasms, Thyroid Nodule, Stage (cooking), lcsh:Science, Thyroid cancer, Cancer, Multidisciplinary, medicine.diagnostic_test, business.industry, lcsh:R, Thyroid, Middle Aged, medicine.disease, 030104 developmental biology, Fine-needle aspiration, medicine.anatomical_structure, Female, lcsh:Q, Radiology, business, 030217 neurology & neurosurgery
Abstract

Over the last 50 years, the incidence of human thyroid cancer disease has seen a significative increment. This comes along with an even higher increment of surgery, since, according to the international guidelines, patients are sometimes addressed to surgery also when the fine needle aspiration gives undetermined cytological diagnosis. As a matter of fact, only 30% of the thyroid glands removed for diagnostic purpose have a post surgical histological report of malignancy: this implies that about 70% of the patients have suffered an unnecessary thyroid removal. Here we show that Raman spectroscopy investigation of thyroid tissues provides reliable cancer diagnosis. Healthy tissues are consistently distinguished from cancerous ones with an accuracy of $$\sim $$ ∼ 90%, and the three cancer typology with highest incidence are clearly identified. More importantly, Raman investigation has evidenced alterations suggesting an early stage of transition of adenoma tissues into cancerous ones. These results suggest that Raman spectroscopy may overcome the limits of current diagnostic tools.

Published
2020

33. Aggressiveness evaluation of borderline serous ovarian tumors by analysis of Psammoma bodies present in cancer tissues using micro-FTIR spectroscopy.

Author

Orsini M, Porcelli F, Bianchi A, Verri M, De Santis S, Sotgiu G, Romano S, and Crescenzi A

Abstract

Borderline ovarian tumor is a type of tumor with generally low malignant potential. However, these tumors pose diagnostic challenges with benign and malignant epithelial ovarian tumors because the clinical symptoms are similar and investigation procedures for specific diagnosis are still debated. In addition, a small number of borderlines transform into high-grade serous ovarian carcinoma with a poor prognosis. Therefore, tools improving a better characterization of high-risk subtypes of borderline tumors to enable understanding of possible unfavorable evolution are essential for patients' management. Psammoma bodies (PBs) are microcalcifications found both in serous epithelial ovarian cancer and serous borderline tumors with possible correlation with disease progression. In this work, the chemical composition of PBs found in the tissues of borderline, high-grade and low-grade ovarian tumors was evaluated using micro-FTIR spectroscopy. Applying principal component analysis to spectral data, it was observed that among the borderline tumors analyzed (1-bl,2-bland3-bl), the PBs of3-blshowed a different chemical content from that of the PBs of the high-grade and low-grade tumors, while the PBs of1-bland2-blappeared to have similar chemical content to the PBs of high- and low-grade tumors. The discriminating wavenumbers were found to be those related to carbonate CO 3 2- (1454, 1413 cm -1 and 872 cm -1 ) and phosphate PO 4 3- (1018 cm -1 and 960 cm -1 ) present in microcalcifications. A higher ratio between peak intensities at 1413 cm -1 and 1018 cm -1 (I 1413 /I 1018 ) was observed in the PBs of3-blcompared with those of high- and low-grade ovarian carcinoma patients, which correlates with higher CO 3 2- content. On the other hand, the PBs of1-bland2-blshowed a CO 3 2- level close to that of the PBs of high- and low-grade patients. Several studies on microcalcifications in breast carcinoma have reported that increased carbonate content is related to decreased tumor aggressiveness. Therefore, case bl-3 appeared to be the less aggressive. The results obtained from FTIR analysis were in agreement with histopathological tumor classification and molecular analysis for BRAFV600E. The FTIR technique could become a reliable tool for identifying borderline low- and high-risk tumors., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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34. Could Raman spectroscopy investigate the changes of cell oxidative stress status in thyroid diseases? A pilot study on cytological samples.

Author

Di Gioacchino M, Verri M, Naciu AM, Paolucci A, di Masi A, Taffon C, Palermo A, Crescenzi A, Ricci MA, and Sodo A

Abstract

The incidence of thyroid nodules is rapidly increasing worldwide. Raman spectroscopy (RS) is a powerful label-free and non-invasive technique, successfully used for early stage diagnosis. Here, RS is proposed as a tool to investigate the thyroid disease, including neoplasms, through the study of cell oxidative stress (OS), which represents one of the main cancer risk factors. In this study, we enrolled 28 patients, submitted to a first and second thyroid fine needle aspiration (FNA) during follow up. The cytological samples were studied by RS and morphological examination. Typical Raman spectra of thyroid cytological samples are reported and the contribution of oxidized and reduced cytochrome b and c and carotenoids are discussed. On the basis of the evolution of the Raman features over the time lapse between the two FNAs, the 28 patients have been classified into 4 different categories and the most representative case for each category is reported and discussed in detail. For each category, the different Raman intensity ratio between oxidized and reduced cytochromes b and c is reported and associated to different cell OS status, along with the presence of carotenoids. Overall, our results support a correlation among changes in oxidative stress, carotenoids uptake and thyroid diseases, which could inspire new fundamental research on biomarkers and signaling pathways involved in thyroid OS., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

Published
2024
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