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Your search keyword '"Vescovi, A.L."' showing total 15 results
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15 results on '"Vescovi, A.L."'

1. Generation of induced pluripotent stem cells (CSSi017-A)(12862) from a patient carrying a repeat expansion in the C9orf72 gene and with amyotrophic lateral sclerosis

Author

Ruotolo, G., primary, D'Anzi, A., additional, Casamassa, A., additional, Mazzoni, M., additional, Ferrari, D., additional, Lombardi, I., additional, Carletti, R.M., additional, D'Asdia, C., additional, Torrente, I., additional, Frezza, K., additional, Lattante, S., additional, Sabatelli, M., additional, Pennuto, M., additional, Vescovi, A.L., additional, and Rosati, J., additional

Published
2024
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2. Generation of induced pluripotent stem cells (CSSi017-A)(12862) from an ALS patient carrying a repeat expansion in the C9orf72 gene.

Author

Ruotolo, G., D'Anzi, A., Casamassa, A., Mazzoni, M., Ferrari, D., Lombardi, I., Carletti, R.M., D'Asdia, C., Torrente, I., Frezza, K., Lattante, S., Sabatelli, M., Pennuto, M., Vescovi, A.L., and Rosati, J.

Abstract

Genetic expansions of the hexanucleotide repeats (GGGGCC) in the C9orf72 gene appear in approximately 40% of patients with familial ALS and 7% of patients with sporadic ALS in the European population, making this mutation one of the most prevalent genetic mutations in ALS. Here, we generated a human induced pluripotent stem cell (hiPSC) line from the dermal fibroblasts of a patient carrying a 56-repeat expansion in an ALS disease-causing allele of C9orf72. These iPSCs showed stable amplification in vitro with normal karyotype and high expression of pluripotent markers and differentiated spontaneously in vivo into three germ layers. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Reply: Quantitative evaluation of the human subventricular zone.

Author

van den Berge, S.A., van Strien, M.E., Korecka, J.A., Dijkstra, A.A., Sluijs, J.A., Kooijman, L., Eggers, R., De Filippis, L., Vescovi, A.L., Verhaagen, J., Van de Berg, W.D.J., Hol, E.M., van den Berge, S.A., van Strien, M.E., Korecka, J.A., Dijkstra, A.A., Sluijs, J.A., Kooijman, L., Eggers, R., De Filippis, L., Vescovi, A.L., Verhaagen, J., Van de Berg, W.D.J., and Hol, E.M.

Published
2012

7. The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain.

Author

Van den Berge, S.A., van Strien, M.E., Korecka, J.A., Dijkstra, A.A., Sluijs, J.A., Kooijman, L., Eggers, R., De Filippis, L., Vescovi, A.L., Verhaagen, J., Van de Berg, W.D.J., Hol, E.M., Van den Berge, S.A., van Strien, M.E., Korecka, J.A., Dijkstra, A.A., Sluijs, J.A., Kooijman, L., Eggers, R., De Filippis, L., Vescovi, A.L., Verhaagen, J., Van de Berg, W.D.J., and Hol, E.M.

Published
2011

9. Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution.

Author

Piccirillo, S. g., Combi, L., Cajola, L., Patrizi, A., Redaelli, S., Bentivegna, A., Baronchelli, S., Maira, Giulio, Pollo, B., Mangiola, Annunziato, Dimeco, F., Dalprà, L., Vescovi, A. l., Piccirillo , S.g., Combi , L., Cajola , L., Patrizi , A., Redaelli , S., Bentivegna , A., Baronchelli , S., Maira , Giulio, Pollo , B., Mangiola, Annunziato (ORCID:0000-0002-1378-4524), Dimeco , F., Dalprà , L., Vescovi , A.l., Piccirillo, S. g., Combi, L., Cajola, L., Patrizi, A., Redaelli, S., Bentivegna, A., Baronchelli, S., Maira, Giulio, Pollo, B., Mangiola, Annunziato, Dimeco, F., Dalprà, L., Vescovi, A. l., Piccirillo , S.g., Combi , L., Cajola , L., Patrizi , A., Redaelli , S., Bentivegna , A., Baronchelli , S., Maira , Giulio, Pollo , B., Mangiola, Annunziato (ORCID:0000-0002-1378-4524), Dimeco , F., Dalprà , L., and Vescovi , A.l.

Published
2009

12. Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells

Author

Zappone, M.V., primary, Galli, R., additional, Catena, R., additional, Meani, N., additional, De Biasi, S., additional, Mattei, E., additional, Tiveron, C., additional, Vescovi, A.L., additional, Lovell-Badge, R., additional, Ottolenghi, S., additional, and Nicolis, S.K., additional

Published
2000
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14. Novel Ways to Treat CNS Dysfunctions.

Author

Vescovi, A.L.

Abstract

Provides information on a study being conducted on neural cell replacement in treating central nervous system degenerative disorders. Reference to study by A.L. Vescovi and E.Y. Snyder published in the July 1999 issue of `Brain Pathology' journal; Definition of neural stem cell (NSC); Isolation and propagation of clones of NSC.

Published
1999

15. Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies

Author

Elena Binda, Nadia Trivieri, Riccardo Ricci, Laura Cajola, Graziano Pesole, Silvia Restelli, Orazio Palumbo, Massimiliano Copetti, Valerio Papa, Fabrizio Giani, Tiziana Latiano, Massimo Carella, Riccardo Pracella, Maria Grazia Cariglia, Angelo L. Vescovi, Dino Amadori, Andrea Arleo, Sergio Alfieri, Antonio Sciuto, Alberto Visioli, Elide Miccinilli, Fabio Dezi, Giulia Gallerani, Visioli, A, Giani, F, Trivieri, N, Pracella, R, Miccinilli, E, Cariglia, M, Palumbo, O, Arleo, A, Dezi, F, Copetti, M, Cajola, L, Restelli, S, Papa, V, Sciuto, A, Latiano, T, Carella, M, Amadori, D, Gallerani, G, Ricci, R, Alfieri, S, Pesole, G, Vescovi, A, Binda, E, Visioli A., Giani F., Trivieri N., Pracella R., Miccinilli E., Cariglia M.G., Palumbo O., Arleo A., Dezi F., Copetti M., Cajola L., Restelli S., Papa V., Sciuto A., Latiano T.P., Carella M., Amadori D., Gallerani G., Ricci R., Alfieri S., Pesole G., Vescovi A.L., and Binda E.

Subjects
0301 basic medicine, CRC stem cell, Research paper, Colorectal cancer, Anti-CRC SCs strategies, CRC biology and biomarkers, CRC circulating stem cells, CRC metastatic stem cells, CRC stem cells, Human colorectal carcinoma (CRC), Stemness, Fluorescent Antibody Technique, Loss of Heterozygosity, CRC metastatic stem cell, Colorectal Neoplasm, Disease, Anti-CRC SCs strategie, Mice, 0302 clinical medicine, Circulating tumor cell, Cell Self Renewal, DNA Copy Number Variation, Stemne, CRC biology and biomarker, General Medicine, Neoplastic Cells, Circulating, Immunohistochemistry, Cell system, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Heterografts, Stem cell, Heterograft, Colorectal Neoplasms, Human, Epithelial-Mesenchymal Transition, DNA Copy Number Variations, Tumor cells, CRC circulating stem cell, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Animals, Humans, Neoplasm Staging, Settore MED/06 - ONCOLOGIA MEDICA, Settore MED/08 - ANATOMIA PATOLOGICA, Animal, business.industry, BIO/13 - BIOLOGIA APPLICATA, Biomarker, medicine.disease, Disease Models, Animal, 030104 developmental biology, Cancer research, Neoplastic Stem Cell, Neoplasm Grading, business, Biomarkers
Abstract

Background Despite their lethality and ensuing clinical and therapeutic relevance, circulating tumor cells (CTCs) from colorectal carcinoma (CRC) remain elusive, poorly characterized biological entities. Methods and findings We perfected a cell system of stable, primary lines from human CRC showing that they possess the full complement of ex- and in-vivo, in xenogeneic models, characteristics of CRC stem cells (CCSCs). Here we show how tumor-initiating, CCSCs cells can establish faithful orthotopic phenocopies of the original disease, which contain cells that spread into the circulatory system. While in the vascular bed, these cells retain stemness, thus qualifying as circulating CCSCs (cCCSCs). This is followed by the establishment of lesions in distant organs, which also contain resident metastatic CCSCs (mCCSCs). Interpretation Our results support the concept that throughout all the stages of CRC, stemness is retained as a continuous property by some of their tumor cells. Importantly, we describe a useful standardized model that can enable isolation and stable perpetuation of human CRC's CCSCs, cCCSCs and mCCSCs, providing a useful platform for studies of CRC initiation and progression that is suitable for the discovery of reliable stage-specific biomarkers and the refinement of new patient-tailored therapies. Fund This work was financially supported by grants from "Ministero della Salute Italiano"(GR-2011-02351534, RC1703IC36 and RC1803IC35) to Elena Binda and from "Associazione Italiana Cancro" (IG-14368) Angelo L. Vescovi. None of the above funders have any role in study design, data collection, data analysis, interpretation, writing the project.

Published
2019
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