1,646 results on '"Vestbo, Jørgen"'
Search Results
2. The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases
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Genovese, Federica, Bager, Cecilie, Frederiksen, Peder, Vazquez, Dario, Sand, Jannie Marie Bülow, Jenkins, R Gisli, Maher, Toby M., Stewart, Iain D., Molyneaux, Philip L., Fahy, William A, Wain, Louise V., Vestbo, Jørgen, Nanthakumar, Carmel, Shaker, Saher Burhan, Hoyer, Nils, Leeming, Diana Julie, George, Jacob, Trebicka, Jonel, Rasmussen, Daniel Guldager Kring, Hansen, Michael K., Cockwell, Paul, Kremer, Daan, Bakker, Stephan JL, Selby, Nicholas M, Reese-Petersen, Alexander Lynge, González, Arantxa, Núñez, Julio, Rossing, Peter, Nissen, Neel I., Boisen, Mogens Karsbøl, Chen, Inna M., Zhao, Lei, Karsdal, Morten A., and Schuppan, Detlef
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- 2024
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3. Lung-function trajectories: relevance and implementation in clinical practice
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Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin, Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, and Agusti, Alvar
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- 2024
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4. Predicting exacerbations in COPD in the Danish general population
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Marott, Jacob Louis, Ingebrigtsen, Truls Sylvan, Çolak, Yunus, Vestbo, Jørgen, Nordestgaard, Børge Grønne, and Lange, Peter
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- 2024
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5. Burden of Uncontrolled Severe Asthma With and Without Elevated Type-2 Inflammatory Biomarkers
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del Olmo, Ricardo, Anderson, Gary, Reddel, Helen, Rabahi, Marcelo, McIvor, Andrew, Sadatsafavi, Mohsen, Weinreich, Ulla, Burgel, Pierre-Régis, Devouassoux, Gilles, Papi, Alberto, Inoue, Hiromasa, Rendon, Adrián, van den Berge, Maarten, Beasley, Richard, García-Navarro, Alvar Agusti, Faner, Rosa, Rivera, José Olaguibel, Janson, Christer, Bilińska-Izydorczyk, Magdalena, Fagerås, Malin, Fihn-Wikander, Titti, Franzén, Stefan, Keen, Christina, Ostridge, Kristoffer, Chalmers, James, Harrison, Timothy, Pavord, Ian, Price, David, Azim, Adnan, Belton, Laura, Blé, Francois-Xavier, Erhard, Clement, Gairy, Kerry, Hughes, Rod, Lassi, Glenda, Müllerová, Hana, Rapsomaniki, Eleni, Scott, Ian Christopher, Chipps, Bradley, Christenson, Stephanie, Make, Barry, Tomaszewski, Erin, Benhabib, Gabriel, Ruiz, Xavier Bocca, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Delfini Cançado, José Eduardo, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, FitzGerald, J. Mark, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Wang, Chen, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Bueno, Carlos Matiz, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, Molina de Salazar, Dora, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Raherison, Chantal, Bonniaud, Philippe, Brun, Olivier, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Bals, Robert, Aries, Sven Philip, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Rendon, Adrian, Javier, Ruth Cerino, Peregrina, Alfredo Domínguez, Corzo, Marco Fernández, Gonzalez, Efraín Montano, Ramírez-Venegas, Alejandra, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van de Ven, Mario, Bakke, Per, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Yoon, Ho Joo, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Hyoung-Kyu, Andújar, Rubén, Anoro, Laura, García, María Buendía, Mozo, Paloma Campo, Campos, Sergio, Maldonado, Francisco Casas, Martínez, Manuel Castilla, Serrano, Carolina Cisneros, Casanova, Lorena Comeche, Corbacho, Dolores, Del Campo Matías, Felix, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Setién, Pedro Gamboa, Clemente, Marta García, Núñez, Ignacio García, Robaina, Jose García, Salmones, Mercedes García, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Pérez de Llano, Luis, Bastida, Ana Pueyo, Rañó, Ana, González-Moro, José Rodríguez, Reig, Albert Roger, Garrido, José Velasco, Curiac, Dan, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jorgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Francis, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Ding, Bo, Chen, Stephanie, Quinton, Anna, Cook, William, and Reddel, Helen K.
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- 2024
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6. Trends in smoking-related diseases by socioeconomic position following a national smoking ban in 2007: a nationwide study in the Danish population
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Jarlstrup, Nanna Schneekloth, Thygesen, Lau C., Pisinger, Charlotta, Vestbo, Jørgen, Grønbæk, Morten, and Tolstrup, Janne S.
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- 2023
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7. Fibrin degradation products and survival in patients with chronic obstructive pulmonary disease: a protocolized prospective observational study
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Kamstrup, Peter, Sivapalan, Pradeesh, Rønn, Christian, Rastoder, Ema, Modin, Daniel, Kristensen, Anna Kjaer, Bendstrup, Elisabeth, Sørensen, Rikke, Biering-Sørensen, Tor, Ulrik, Charlotte Suppli, Vestbo, Jørgen, and Jensen, Jens-Ulrik
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- 2023
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8. Rethinking Blood Eosinophils for Assessing ICS Response in COPD: A Post Hoc Analysis From FLAME
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Mathioudakis, Alexander G., Bate, Sebastian, Sivapalan, Pradeesh, Stæhr Jensen, Jens-Ulrik, Singh, Dave, and Vestbo, Jørgen
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- 2024
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9. Impact of the metabolic syndrome on cardiopulmonary morbidity and mortality in individuals with lung function impairment: a prospective cohort study of the Danish general population
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Marott, Jacob Louis, Ingebrigtsen, Truls Sylvan, Çolak, Yunus, Kankaanranta, Hannu, Bakke, Per Sigvald, Vestbo, Jørgen, Nordestgaard, Børge Grønne, and Lange, Peter
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- 2023
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10. Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments
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Aliberti, Stefano, Barac, Aleksandra, Blasi, Francesco, Chastre, Jean, Clarke, Mike, Ciloniz, Catia, Dark, Paul, Dimopoulos, George, Fally, Markus, Felton, Timothy W., Gramegna, Andrea, Hansel, Jan, Haseeb, Faiuna, Kouta, Ahmed, Mathioudakis, Alexander G., Polverino, Eva, Roger, Claire, Robey, Rebecca C., Rovina, Nikoletta, Stolz, Daiana, Vestbo, Jørgen, Waterer, Grant, Welte, Tobias, Williams, Thomas, Williamson, Paula R., Wootton, Dan G., and van Wouter, Geffen
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- 2023
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11. Cluster Analyses From the Real-World NOVELTY Study: Six Clusters Across the Asthma-COPD Spectrum
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Olmo, Ricardo del, Anderson, Gary, Reddel, Helen, Rabahi, Marcelo, McIvor, Andrew, Sadatsafavi, Mohsen, Weinreich, Ulla, Burgel, Pierre-Régis, Devouassoux, Gilles, Papi, Alberto, Inoue, Hiromasa, Rendon, Adrián, van den Berge, Maarten, Beasley, Richard, García-Navarro, Alvar Agusti, Faner, Rosa, Olaguibel Rivera, José, Janson, Christer, Bilińska-Izydorczyk, Magdalena, Fagerås, Malin, Fihn-Wikander, Titti, Franzén, Stefan, Keen, Christina, Ostridge, Kristoffer, Chalmers, James, Harrison, Timothy, Pavord, Ian, Price, David, Azim, Adnan, Belton, Laura, Blé, Francois-Xavier, Erhard, Clement, Gairy, Kerry, Hughes, Rod, Lassi, Glenda, Müllerová, Hana, Rapsomaniki, Eleni, Scott, Ian Christopher, Chipps, Bradley, Christenson, Stephanie, Make, Barry, Tomaszewski, Erin, Benhabib, Gabriel, Ruiz, Xavier Bocca, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Cançado, José Eduardo Delfini, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, FitzGerald, J. Mark, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Wang, Chen, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Bueno, Carlos Matiz, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, de Salazar, Dora Molina, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Raherison, Chantal, Bonniaud, Philippe, Brun, Olivier, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Bals, Robert, Aries, Sven Philip, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Rendon, Adrian, Cerino Javier, Ruth, Domínguez Peregrina, Alfredo, Fernández Corzo, Marco, Montano Gonzalez, Efraín, Ramírez-Venegas, Alejandra, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van de Ven, Mario, Bakke, Per, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Yoon, Ho Joo, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Hyoung-Kyu, García-Navarro, Alvar Agustí, Andújar, Rubén, Anoro, Laura, Buendía García, María, Mozo, Paloma Campo, Campos, Sergio, Casas Maldonado, Francisco, Castilla Martínez, Manuel, Cisneros Serrano, Carolina, Comeche Casanova, Lorena, Corbacho, Dolores, Campo Matías, Felix Del, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Gamboa Setién, Pedro, García Clemente, Marta, Núñez, Ignacio García, García Robaina, Jose, García Salmones, Mercedes, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Pérez de Llano, Luis, Pueyo Bastida, Ana, Rañó, Ana, Rodríguez González-Moro, José, Reig, Albert Roger, Velasco Garrido, José, Curiac, Dan, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jørgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Francis, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Bansal, Aruna T., Agustí, Alvar, Fageras, Malin, Alacqua, Marianna, and Reddel, Helen K.
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- 2023
- Full Text
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12. Structural Predictors of Lung Function Decline in Young Smokers with Normal Spirometry
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Ritchie, Andrew I., primary, Donaldson, Gavin C., additional, Hoffman, Eric A., additional, Allinson, James P., additional, Bloom, Chloe I., additional, Bolton, Charlotte E., additional, Choudhury, Gourab, additional, Gerard, Sarah E., additional, Guo, Junfeng, additional, Alves-Moreira, Luana, additional, McGarvey, Lorcan, additional, Sapey, Elizabeth, additional, Stockley, Robert A., additional, Yip, K. P., additional, Singh, Dave, additional, Wilkinson, Tom, additional, Fageras, Malin, additional, Ostridge, Kristoffer, additional, Jöns, Olaf, additional, Bucchioni, Enrica, additional, Compton, Chris H., additional, Jones, Paul, additional, Mezzi, Karen, additional, Vestbo, Jørgen, additional, Calverley, Peter M. A., additional, Wedzicha, Jadwiga A., additional, Kempka, Sophie, additional, King, Bernedette, additional, Beech, Augusta S., additional, Bikov, Andras, additional, Ferguson, S., additional, Kong, C.W., additional, Holmes, C., additional, Deans, Andrew, additional, de la Hoz, A., additional, Hamblin, Angus, additional, Braddy-Green, Aaron, additional, Mah, Jordina S.Y., additional, Jenkins, Alexander, additional, Almeida, P., additional, Kots, M., additional, Mohan, D., additional, Prosper, S., additional, Bottoli, I., additional, Jarrold, Ian, additional, and Snell, Noel, additional
- Published
- 2024
- Full Text
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13. Study Protocol: COPD - Eosinophil-guided Reduction of Inhaled Corticosteroids (COPERNICOS)
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Rønn, Christian, primary, Bonnesen, Barbara, additional, Alispahic, Imane Achir, additional, Toennesen, Louise, additional, Sivapalan, Pradee, additional, Kjærgaard, Jakob Lyngby, additional, Moberg, Mia, additional, Ulrik, Charl Suppli, additional, Harboe, Zitta Barella, additional, Browatzki, Andrea, additional, Jensen, Torben Tranborg, additional, Meyer, Christian, additional, Bødtger, Uffe, additional, Bendstrup, Elisabeth, additional, Johansson, Sofie Lock, additional, Kaiser, Diana Utrecht, additional, Hyldgaard, Charlotte, additional, Vestbo, Jørgen, additional, and Jensen, Jens Ulrik Stæhr, additional
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- 2024
- Full Text
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14. Lung-function trajectories: relevance and implementation in clinical practice
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Melén, Erik, primary, Faner, Rosa, additional, Allinson, James P, additional, Bui, Dinh, additional, Bush, Andrew, additional, Custovic, Adnan, additional, Garcia-Aymerich, Judith, additional, Guerra, Stefano, additional, Breyer-Kohansal, Robab, additional, Hallberg, Jenny, additional, Lahousse, Lies, additional, Martinez, Fernando D, additional, Merid, Simon Kebede, additional, Powell, Pippa, additional, Pinnock, Hilary, additional, Stanojevic, Sanja, additional, Vanfleteren, Lowie E G W, additional, Wang, Gang, additional, Dharmage, Shyamali C, additional, Wedzicha, Jadwiga, additional, Agusti, Alvar, additional, Abellan, Alicia, additional, Adcock, Ian, additional, Afzal, Shoaib, additional, Alter, Peter, additional, Backman, Helena, additional, Bertels, Xander, additional, Bloom, Chloe, additional, Bønnelykke, Klaus, additional, Breyer, Marie-Kathrin, additional, Casas, Sandra, additional, Chung, Fan (Kian), additional, Colak, Yunus, additional, Cosio, Borja G., additional, Duijts, Liesbeth, additional, Fabbri, Leonardo, additional, Fontanella, Sara, additional, Fuertes, Elaine, additional, Gonzalez, Juan Ramón, additional, Granell, Raquel, additional, Hartl, Sylvia, additional, Hernandez-Pacheco, Natalia, additional, Holloway, John, additional, Jarvis, Deborah, additional, Koefoed, Hans Jacob, additional, Kole, Tessa, additional, Kumar, Ashish, additional, Langhammer, Arnulf, additional, Lindberg, Anne, additional, Llopis, Maria, additional, Maitland van der Zee, Anke-Hilse, additional, Meteran, Howraman, additional, Minelli, Cosetta, additional, Nwaru, Bright, additional, Olvera, Nuria, additional, Peralta, Gabriela, additional, Ritchie, Andrew, additional, Rönmark, Eva, additional, Ross Chapman, James, additional, Sangüesa Boix, Júlia, additional, Schikowski, Tamara, additional, Schlünssen, Vivi, additional, Shaheen, Seif, additional, Sigsgaard, Torben, additional, Standl, Marie, additional, Talaei, Mohammad, additional, Ullah, Anhar, additional, Ullman, Anders, additional, Valencia-Hernandez, Carlos, additional, van den Berge, Maarten, additional, van Dijk, Yoni, additional, Vestbo, Jørgen, additional, Vijverberg, Susanne, additional, Vikjord, Sigrid Anna, additional, Volgelmeier, Claus, additional, Vonk, Judith, additional, and Zounemat Kermani, Nazanin, additional
- Published
- 2024
- Full Text
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15. Plasma immunoglobulin E and risk of exacerbation and mortality in chronic obstructive pulmonary disease: A contemporary population-based cohort
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Çolak, Yunus, Ingebrigtsen, Truls S., Nordestgaard, Børge G., Marott, Jacob L., Lange, Peter, Vestbo, Jørgen, and Afzal, Shoaib
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- 2022
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16. The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
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Benhabib, Gabriel, Mandhane, Piushkumar, Ruiz, Xavier Bocca, McIvor, Andrew, Olmo, Ricardo del, Pek, Bonavuth, Lisanti, Raul Eduardo, Petrella, Robert, Marino, Gustavo, Stollery, Daniel, Mattarucco, Walter, Chen, Meihua, Nogueira, Juan, Chen, Yan, Parody, Maria, Gu, Wei, Pascale, Pablo, Hui, Kim Ming Christopher, Rodriguez, Pablo, Li, Manxiang, Silva, Damian, Li, Shiyue, Svetliza, Graciela, Ma, Lijun, Victorio, Carlos F., Qin, Guangyue, Rolon, Roxana Willigs, Song, Weidong, Yañez, Anahi, Tan, Wei, Baines, Stuart, Tang, Yijun, Bowler, Simon, Wang, Chen, Bremner, Peter, Wang, Tan, Bull, Sheetal, Wen, Fuqiang, Carroll, Patrick, Wu, Feng, Chaalan, Mariam, Xiang, PingChao, Farah, Claude, Xiao, Zuke, Hammerschlag, Gary, Xiong, Shengdao, Hancock, Kerry, Yang, Jinghua, Harrington, Zinta, Yang, Jingping, Katsoulotos, Gregory, Zhang, Caiqing, Kim, Joshua, Zhang, Min, Langton, David, Zhang, Ping, Lee, Donald, Zhang, Wei, Peters, Matthew, Zheng, Xiaohe, Prassad, Lakshman, Zhu, Dan, Reddel, Helen, Bolivar Grimaldos, Fabio, Sajkov, Dimitar, Arboleda, Alejandra Cañas, Santiago, Francis, Bueno, Carlos Matiz, Simpson, Frederick Graham, Molina de Salazar, Dora, Tai, Sze, Bendstrup, Elisabeth, Thomas, Paul, Hilberg, Ole, Wark, Peter, Kjellerup, Carsten, Cançado, José Eduardo Delfini, Weinreich, Ulla, Cunha, Thúlio, Bonniaud, Philippe, Lima, Marina, Brun, Olivier, Cardoso, Alexandre Pinto, Burgel, Pierre-Régis, Rabahi, Marcelo, Chouaid, Christos, Anees, Syed, Couturaud, Francis, Bertley, John, de Blic, Jacques, Bell, Alan, Debieuvre, Didier, Cheema, Amarjit, Delsart, Dominique, Chouinard, Guy, Demaegdt, Axelle, Csanadi, Michael, Demoly, Pascal, Dhar, Anil, Deschildre, Antoine, Dhillon, Ripple, Devouassoux, Gilles, FitzGerald, J. Mark, Egron, Carole, Kanawaty, David, Falchero, Lionel, Kelly, Allan, Goupil, François, Killorn, William, Kessler, Romain, Landry, Daniel, Le Roux, Pascal, Luton, Robert, Mabire, Pascal, Mahay, Guillaume, Ide, Yumiko, Martinez, Stéphanie, Inomata, Minehiko, Melloni, Boris, Inoue, Hiromasa, Moreau, Laurent, Inoue, Koji, Raherison, Chantal, Inoue, Sumito, Riviere, Emilie, Kato, Motokazu, Roux-Claudé, Pauline, Kawasaki, Masayuki, Soulier, Michel, Kawayama, Tomotaka, Vignal, Guillaume, Kita, Toshiyuki, Yaici, Azzedine, Kobayashi, Kanako, Aries, Sven Philip, Koto, Hiroshi, Bals, Robert, Nishi, Koichi, Beck, Ekkehard, Saito, Junpei, Deimling, Andreas, Shimizu, Yasuo, Feimer, Jan, Shirai, Toshihiro, Grimm-Sachs, Vera, Sugihara, Naruhiko, Groth, Gesine, Takahashi, Ken-ichi, Herth, Felix, Tashimo, Hiroyuki, Hoheisel, Gerhard, Tomii, Keisuke, Kanniess, Frank, Yamada, Takashi, Lienert, Thomas, Yanai, Masaru, Mronga, Silke, Javier, Ruth Cerino, Reinhardt, Jörg, Domínguez Peregrina, Alfredo, Schlenska, Christian, Corzo, Marco Fernández, Stolpe, Christoph, Montano Gonzalez, Efraín, Teber, Ishak, Ramírez-Venegas, Alejandra, Timmermann, Hartmut, Rendon, Adrian, Ulrich, Thomas, Boersma, Willem, Velling, Peter, Djamin, R.S., Wehgartner-Winkler, Sabina, Eijsvogel, Michiel, Welling, Juergen, Franssen, Frits, Winkelmann, Ernst-Joachim, Goosens, Martijn, Barbetta, Carlo, Graat-Verboom, Lidwien, Braido, Fulvio, Veen, Johannes in 't, Cardaci, Vittorio, Janssen, Rob, Clini, Enrico Maria, Kuppens, Kim, Costantino, Maria Teresa, van den Berge, Maarten, Cuttitta, Giuseppina, van de Ven, Mario, di Gioacchino, Mario, Brunstad, Ole Petter, Fois, Alessandro, Einvik, Gunnar, Foschino-Barbaro, Maria Pia, Høines, Kristian Jong, Gammeri, Enrico, Khusrawi, Alamdar, Inchingolo, Riccardo, Oien, Torbjorn, Lavorini, Federico, Chang, Yoon-Seok, Molino, Antonio, Cho, Young Joo, Nucera, Eleonora, Hwang, Yong Il, Papi, Alberto, Kim, Woo Jin, Patella, Vincenzo, Koh, Young-Il, Pesci, Alberto, Lee, Byung-Jae, Ricciardolo, Fabio, Lee, Kwan-Ho, Rogliani, Paola, Lee, Sang-Pyo, Sarzani, Riccardo, Lee, Yong Chul, Vancheri, Carlo, Lim, Seong Yong, Vincenti, Rigoletta, Min, Kyung Hun, Endo, Takeo, Oh, Yeon-Mok, Fujita, Masaki, Park, Choon-Sik, Hara, Yu, Park, Hae-Sim, Horiguchi, Takahiko, Park, Heung-Woo, Hosoi, Keita, Rhee, Chin Kook, Yoon, Ho Joo, Morice, Alyn, Yoon, Hyoung-Kyu, Pandya, Preeti, García-Navarro, Alvar Agusti, Patel, Manish, Andújar, Rubén, Roy, Kay, Anoro, Laura, Sathyamurthy, Ramamurthy, García, María Buendía, Thiagarajan, Swaminathan, Mozo, Paloma Campo, Turner, Alice, Campos, Sergio, Vestbo, Jorgen, Maldonado, Francisco Casas, Wedzicha, Wisia, Castilla Martínez, Manuel, Wilkinson, Tom, Serrano, Carolina Cisneros, Wilson, Pete, Comeche Casanova, Lorena, Al-Asadi, Lo’Ay, Corbacho, Dolores, Anholm, James, Campo Matías, Felix Del, Averill, Frank, Echave-Sustaeta, Jose, Bansal, Sandeep, Corral, Gloria Francisco, Baptist, Alan, Gamboa Setién, Pedro, Campbell, Colin, García Clemente, Marta, Campos, Michael A., Núñez, Ignacio García, Chipps, Bradley, Robaina, Jose García, Crook, Gretchen, García Salmones, Mercedes, DeLeon, Samuel, Marín Trigo, Jose Maria, Eid, Alain, Fernandez, Marta Nuñez, Epstein, Ellen, Palomo, Sara Nuñez, Fritz, Stephen, Olaguibel Rivera, José, Harris, Hoadley, de Llano, Luis Pérez, Hewitt, Mitzie, Pueyo Bastida, Ana, Holguin, Fernando, Rañó, Ana, Hudes, Golda, Rodríguez González-Moro, José, Jackson, Richard, Reig, Albert Roger, Kaufman, Alan, Velasco Garrido, José, Kaufman, David, Curiac, Dan, Klapholz, Ari, Janson, Christer, Krishna, Harshavardhan, Lif-Tiberg, Cornelia, Lee, Daria, Luts, Anders, Lin, Robert, Råhlen, Lennart, Maselli-Caceres, Diego, Rustscheff, Stefan, Mehta, Vinay, Adams, Frances, Moy, James N., Bradman, Drew, Nwokoro, Ugo, Broughton, Emma, Parikh, Purvi, Cosgrove, John, Parikh, Sudhir, Flood-Page, Patrick, Perrino, Frank, Fuller, Elizabeth, Ruhlmann, James, Harrison, Timothy, Sassoon, Catherine, Hartley, David, Settipane, Russell A., Hattotuwa, Keith, Sousa, Daniel, Jones, Gareth, Sriram, Peruvemba, Lewis, Keir, Wachs, Richard, McGarvey, Lorcan, Golam, Sarowar Muhammad, Beasley, Richard, FitzGerald, J Mark, Harrison, Tim, Hughes, Rod, Müllerová, Hana, Olaguibel, José María, Rapsomaniki, Eleni, Reddel, Helen K., and Sadatsafavi, Mohsen
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- 2022
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17. Frequent productive cough: Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study
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Benhabib, Gabriel, Ruiz, Xavier Bocca, Olmo, Ricardo del, Lisanti, Raul Eduardo, Marino, Gustavo, Mattarucco, Walter, Nogueira, Juan, Parody, Maria, Pascale, Pablo, Rodriguez, Pablo, Silva, Damian, Svetliza, Graciela, Victorio, Carlos F., Rolon, Roxana Willigs, Yañez, Anahi, Baines, Stuart, Bowler, Simon, Bremner, Peter, Bull, Sheetal, Carroll, Patrick, Chaalan, Mariam, Farah, Claude, Hammerschlag, Gary, Hancock, Kerry, Harrington, Zinta, Katsoulotos, Gregory, Kim, Joshua, Langton, David, Lee, Donald, Peters, Matthew, Prassad, Lakshman, Reddel, Helen, Sajkov, Dimitar, Santiago, Francis, Simpson, Frederick Graham, Tai, Sze, Thomas, Paul, Wark, Peter, Delfini Cançado, José Eduardo, Cunha, Thúlio, Lima, Marina, Cardoso, Alexandre Pinto, Rabahi, Marcelo, Anees, Syed, Bertley, John, Bell, Alan, Cheema, Amarjit, Chouinard, Guy, Csanadi, Michael, Dhar, Anil, Dhillon, Ripple, FitzGerald, J. Mark, Kanawaty, David, Kelly, Allan, Killorn, William, Landry, Daniel, Luton, Robert, Mandhane, Piushkumar, McIvor, Andrew, Pek, Bonavuth, Petrella, Robert, Stollery, Daniel, Chen, Meihua, Chen, Yan, Gu, Wei, Christopher Hui, Kim Ming, Li, Manxiang, Li, Shiyue, Lijun, Ma, Qin, Guangyue, Song, Weidong, Tan, Wei, Tang, Yijun, Wang, Chen, Wang, Tan, Wen, Fuqiang, Wu, Feng, Xiang, PingChao, Xiao, Zuke, Xiong, Shengdao, Yang, Jinghua, Yang, Jingping, Zhang, Caiqing, Zhang, Min, Zhang, Ping, Zhang, Wei, Zheng, Xiaohe, Zhu, Dan, Grimaldos, Fabio Bolivar, Arboleda, Alejandra Cañas, Bueno, Carlos Matiz, Molina de Salazar, Dora, Bendstrup, Elisabeth, Hilberg, Ole, Kjellerup, Carsten, Weinreich, Ulla, Bonniaud, Philippe, Brun, Olivier, Burgel, Pierre-Régis, Chouaid, Christos, Couturaud, Francis, de Blic, Jacques, Debieuvre, Didier, Delsart, Dominique, Demaegdt, Axelle, Demoly, Pascal, Deschildre, Antoine, Devouassoux, Gilles, Egron, Carole, Falchero, Lionel, Goupil, François, Kessler, Romain, Le Roux, Pascal, Mabire, Pascal, Mahay, Guillaume, Martinez, Stéphanie, Melloni, Boris, Moreau, Laurent, Raherison, Chantal, Riviere, Emilie, Roux-Claudé, Pauline, Soulier, Michel, Vignal, Guillaume, Yaici, Azzedine, Aries, Sven Philip, Bals, Robert, Beck, Ekkehard, Deimling, Andreas, Feimer, Jan, Grimm-Sachs, Vera, Groth, Gesine, Herth, Felix, Hoheisel, Gerhard, Kanniess, Frank, Lienert, Thomas, Mronga, Silke, Reinhardt, Jörg, Schlenska, Christian, Stolpe, Christoph, Teber, Ishak, Timmermann, Hartmut, Ulrich, Thomas, Velling, Peter, Wehgartner-Winkler, Sabina, Welling, Juergen, Winkelmann, Ernst-Joachim, Barbetta, Carlo, Braido, Fulvio, Cardaci, Vittorio, Clini, Enrico Maria, Costantino, Maria Teresa, Cuttitta, Giuseppina, di Gioacchino, Mario, Fois, Alessandro, Foschino-Barbaro, Maria Pia, Gammeri, Enrico, Inchingolo, Riccardo, Lavorini, Federico, Molino, Antonio, Nucera, Eleonora, Papi, Alberto, Patella, Vincenzo, Pesci, Alberto, Ricciardolo, Fabio, Rogliani, Paola, Sarzani, Riccardo, Vancheri, Carlo, Vincenti, Rigoletta, Endo, Takeo, Fujita, Masaki, Hara, Yu, Horiguchi, Takahiko, Hosoi, Keita, Ide, Yumiko, Inomata, Minehiko, Inoue, Hiromasa, Inoue, Koji, Inoue, Sumito, Kato, Motokazu, Kawasaki, Masayuki, Kawayama, Tomotaka, Kita, Toshiyuki, Kobayashi, Kanako, Koto, Hiroshi, Nishi, Koichi, Saito, Junpei, Shimizu, Yasuo, Shirai, Toshihiro, Sugihara, Naruhiko, Takahashi, Ken-ichi, Tashimo, Hiroyuki, Tomii, Keisuke, Yamada, Takashi, Yanai, Masaru, Javier, Ruth Cerino, Peregrina, Alfredo Domínguez, Corzo, Marco Fernández, Gonzalez, Efraín Montano, Ramírez-Venegas, Alejandra, Rendon, Adrian, Boersma, Willem, Djamin, R.S., Eijsvogel, Michiel, Franssen, Frits, Goosens, Martijn, Graat-Verboom, Lidwien, Veen, Johannes in 't, Janssen, Rob, Kuppens, Kim, van den Berge, Maarten, van de Ven, Mario, Brunstad, Ole Petter, Einvik, Gunnar, Høines, Kristian Jong, Khusrawi, Alamdar, Oien, Torbjorn, Chang, Yoon-Seok, Cho, Young Joo, Hwang, Yong Il, Kim, Woo Jin, Koh, Young-Il, Lee, Byung-Jae, Lee, Kwan-Ho, Lee, Sang-Pyo, Lee, Yong Chul, Lim, Seong Yong, Min, Kyung Hun, Oh, Yeon-Mok, Park, Choon-Sik, Park, Hae-Sim, Park, Heung-Woo, Rhee, Chin Kook, Yoon, Ho Joo, Yoon, Hyoung-Kyu, García-Navarro, Alvar Agusti, Andújar, Rubén, Anoro, Laura, García, María Buendía, Mozo, Paloma Campo, Campos, Sergio, Maldonado, Francisco Casas, Martínez, Manuel Castilla, Serrano, Carolina Cisneros, Casanova, Lorena Comeche, Corbacho, Dolores, Del Campo Matías, Felix, Echave-Sustaeta, Jose, Corral, Gloria Francisco, Setién, Pedro Gamboa, Clemente, Marta García, Núñez, Ignacio García, Robaina, Jose García, Salmones, Mercedes García, Marín Trigo, Jose Maria, Fernandez, Marta Nuñez, Palomo, Sara Nuñez, Rivera, José Olaguibel, Pérez de Llano, Luis, Bastida, Ana Pueyo, Rañó, Ana, González-Moro, José Rodríguez, Reig, Albert Roger, Garrido, José Velasco, Curiac, Dan, Janson, Christer, Lif-Tiberg, Cornelia, Luts, Anders, Råhlen, Lennart, Rustscheff, Stefan, Adams, Frances, Bradman, Drew, Broughton, Emma, Cosgrove, John, Flood-Page, Patrick, Fuller, Elizabeth, Harrison, Timothy, Hartley, David, Hattotuwa, Keith, Jones, Gareth, Lewis, Keir, McGarvey, Lorcan, Morice, Alyn, Pandya, Preeti, Patel, Manish, Roy, Kay, Sathyamurthy, Ramamurthy, Thiagarajan, Swaminathan, Turner, Alice, Vestbo, Jorgen, Wedzicha, Wisia, Wilkinson, Tom, Wilson, Pete, Al-Asadi, Lo’Ay, Anholm, James, Averill, Frank, Bansal, Sandeep, Baptist, Alan, Campbell, Colin, Campos, Michael A., Chipps, Bradley, Crook, Gretchen, DeLeon, Samuel, Eid, Alain, Epstein, Ellen, Fritz, Stephen, Harris, Hoadley, Hewitt, Mitzie, Holguin, Fernando, Hudes, Golda, Jackson, Richard, Kaufman, Alan, Kaufman, David, Klapholz, Ari, Krishna, Harshavardhan, Lee, Daria, Lin, Robert, Maselli-Caceres, Diego, Mehta, Vinay, Moy, James N., Nwokoro, Ugo, Parikh, Purvi, Parikh, Sudhir, Perrino, Frank, Ruhlmann, James, Sassoon, Catherine, Settipane, Russell A., Sousa, Daniel, Sriram, Peruvemba, Wachs, Richard, Hughes, Rod, Rapsomaniki, Eleni, Keen, Christina, Make, Barry J., Tomaszewski, Erin L., Müllerová, Hana, and Reddel, Helen K.
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- 2022
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18. Potential clinical implications of targeted spirometry for detection of COPD: A contemporary population-based cohort study
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Çolak, Yunus, Nordestgaard, Børge G., Vestbo, Jørgen, Afzal, Shoaib, and Lange, Peter
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- 2022
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19. Significantly increased risk of chronic obstructive pulmonary disease amongst adults with predominantly mild congenital heart disease
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Byrne, Dominic J. F., Williams, Simon G., Nakev, Apostol, Frain, Simon, Baross, Stephanie L., Vestbo, Jørgen, Keavney, Bernard D., and Talavera, David
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- 2022
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20. Cardiovascular predictors of mortality and exacerbations in patients with COPD
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Alter, Peter, Lucke, Tanja, Watz, Henrik, Andreas, Stefan, Kahnert, Kathrin, Trudzinski, Franziska C., Speicher, Tim, Söhler, Sandra, Bals, Robert, Waschki, Benjamin, Welte, Tobias, Rabe, Klaus F., Vestbo, Jørgen, Wouters, Emiel F. M., Vogelmeier, Claus F., and Jörres, Rudolf A.
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- 2022
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21. Exacerbation history, severity of dyspnoea and maintenance treatment predicts risk of future exacerbations in patients with COPD in the general population
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Marott, Jacob Louis, Çolak, Yunus, Ingebrigtsen, Truls Sylvan, Vestbo, Jørgen, Nordestgaard, Børge Grønne, and Lange, Peter
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- 2022
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22. Changes in lung function in European adults born between 1884 and 1996 and implications for the diagnosis of lung disease: a cross-sectional analysis of ten population-based studies
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Allinson, James P, Afzal, Shoaib, Çolak, Yunus, Jarvis, Debbie, Backman, Helena, van den Berge, Maarten, Boezen, H Marike, Breyer, Marie-Kathrin, Breyer-Kohansal, Robab, Brusselle, Guy, Burghuber, Otto C, Faner, Rosa, Hartl, Sylvia, Lahousse, Lies, Langhammer, Arnulf, Lundbäck, Bo, Nwaru, Bright I, Rönmark, Eva, Vikjord, Sigrid A Aalberg, Vonk, Judith M, Wijnant, Sara R A, Lange, Peter, Nordestgaard, Børge G, Olvera, Nuria, Agusti, Alvar, Donaldson, Gavin C, Wedzicha, Jadwiga A, Vestbo, Jørgen, and Vanfleteren, Lowie E G W
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- 2022
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23. AM/PM dosing of LAMA for COPD: a randomized controlled trial protocol using digital recruitment and registries.
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Sivapalan, Pradeesh, Rømer, Valdemar, Klausen, Tobias Wirenfeldt, Johansen, Niklas Dyrby, Pareek, Manan, Modin, Daniel, Mathioudakis, Alexander, Vestbo, Jørgen, Eklöf, Josefin, Jordan, Alexander, Hurst, John R., Biering-Sørensen, Tor, and Jensen, Jens-Ulrik
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- 2024
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24. The association between beta-blocker therapy and daytime sleepiness in obstructive sleep apnoea
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Meszaros, Martina, Mathioudakis, Alexander G., Xanthoudaki, Maria, Sircu, Victoria, Nena, Evangelia, Vestbo, Jørgen, Corlateanu, Alexandru, Steiropoulos, Paschalis, and Bikov, Andras
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- 2021
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25. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease
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Yun, Jeong H, Lamb, Andrew, Chase, Robert, Singh, Dave, Parker, Margaret M, Saferali, Aabida, Vestbo, Jørgen, Tal-Singer, Ruth, Castaldi, Peter J, Silverman, Edwin K, Hersh, Craig P, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Beaty, Terri, Begum, Ferdouse, Busch, Robert, Cho, Michael, DeMeo, Dawn L, Boueiz, Adel R, Foreman, Marilyn G, Halper-Stromberg, Eitan, Hansel, Nadia N, Hardin, Megan E, Hayden, Lystra P, Hetmanski, Jacqueline, Hobbs, Brian D, Hokanson, John E, Laird, Nan, Lange, Christoph, Lutz, Sharon M, McDonald, Merry-Lynn, Qiao, Dandi, Santorico, Stephanie, Silverman, E, Wan, Emily S, Won, Sungho, Qaisi, Mustafa Al, Coxson, Harvey O, Gray, Teresa, Han, MeiLan K, Hoffman, Eric A, Humphries, Stephen, Jacobson, Francine L, Judy, Philip F, Kazerooni, Ella A, Kluiber, Alex, Lynch, David A, Newell, John D, Ross, James C, San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stinson, Douglas, Stoel, Berend C, Tschirren, Juerg, Van Beek, Edwin, van Ginneken, Bram, van Rikxoort, Eva, Washko, George, Wilson, Carla G, Jensen, Robert, Everett, Douglas, Crooks, Jim, Moore, Camille, Strand, Matt, Hughes, John, Kinney, Gregory, Pratte, Katherine, Young, Kendra A, Curtis, Jeffrey L, Martinez, Carlos H, Pernicano, Perry G, Hanania, Nicola, Alapat, Philip, Atik, Mustafa, Bandi, Venkata, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Nachiappan, Arun, Parulekar, Amit, Hersh, Craig, Barr, R Graham, Austin, John, D'Souza, Belinda, Pearson, Gregory DN, and Rozenshtein, Anna
- Subjects
Lung ,Chronic Obstructive Pulmonary Disease ,Clinical Research ,Respiratory ,Aged ,Disease Progression ,Eosinophils ,Female ,Humans ,Leukocyte Count ,Longitudinal Studies ,Male ,Middle Aged ,Observational Studies as Topic ,Pulmonary Disease ,Chronic Obstructive ,Chronic obstructive pulmonary disease ,asthma ,eosinophil ,exacerbation ,COPDGene and ECLIPSE Investigators ,Immunology ,Allergy - Abstract
BACKGROUND:Eosinophilic airway inflammation in patients with chronic obstructive pulmonary disease (COPD) is associated with exacerbations and responsivity to steroids, suggesting potential shared mechanisms with eosinophilic asthma. However, there is no consistent blood eosinophil count that has been used to define the increased exacerbation risk. OBJECTIVE:We sought to investigate blood eosinophil counts associated with exacerbation risk in patients with COPD. METHODS:Blood eosinophil counts and exacerbation risk were analyzed in patients with moderate-to-severe COPD by using 2 independent studies of former and current smokers with longitudinal data. The Genetic Epidemiology of COPD (COPDGene) study was analyzed for discovery (n = 1,553), and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study was analyzed for validation (n = 1,895). A subset of the ECLIPSE study subjects were used to assess the stability of blood eosinophil counts over time. RESULTS:COPD exacerbation risk increased with higher eosinophil counts. An eosinophil count threshold of 300 cells/μL or greater showed adjusted incidence rate ratios for exacerbations of 1.32 in the COPDGene study (95% CI, 1.10-1.63). The cutoff of 300 cells/μL or greater was validated for prospective risk of exacerbation in the ECLIPSE study, with adjusted incidence rate ratios of 1.22 (95% CI, 1.06-1.41) using 3-year follow-up data. Stratified analysis confirmed that the increased exacerbation risk associated with an eosinophil count of 300 cells/μL or greater was driven by subjects with a history of frequent exacerbations in both the COPDGene and ECLIPSE studies. CONCLUSIONS:Patients with moderate-to-severe COPD and blood eosinophil counts of 300 cells/μL or greater had an increased risk exacerbations in the COPDGene study, which was prospectively validated in the ECLIPSE study.
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- 2018
26. State of the art review | Advances in COPD imaging using CT and MRI: Linkage with lung physiology and clinical outcomes
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Elbehairy, Amany F., primary, Marshall, Helen, additional, Naish, Josephine H., additional, Wild, Jim M., additional, Parraga, Grace, additional, Horsley, Alexander, additional, and Vestbo, Jørgen, additional
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- 2024
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27. Susceptible Young Adults and Development of COPD Later in Life
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Çolak, Yunus, primary, Lange, Peter, additional, Vestbo, Jørgen, additional, Nordestgaard, Børge G, additional, and Afzal, Shoaib, additional
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- 2024
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28. Type-2 inflammation and lung function decline in chronic airway disease in the general population
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Çolak, Yunus, primary, Afzal, Shoaib, additional, Marott, Jacob Louis, additional, Vestbo, Jørgen, additional, Nordestgaard, Børge Grønne, additional, and Lange, Peter, additional
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- 2024
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29. Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
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Papi, Alberto, primary, Hughes, Rod, additional, del Olmo, Ricardo, additional, Agusti, Alvar, additional, Chipps, Bradley E., additional, Make, Barry, additional, Tomaszewski, Erin, additional, Peres Da Costa, Keith, additional, Srivastava, Divyansh, additional, Vestbo, Jørgen, additional, Janson, Christer, additional, Burgel, Pierre-Régis, additional, and Price, David, additional
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- 2024
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30. Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure
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Lagan, Jakub, Schelbert, Erik B., Naish, Josephine H., Vestbo, Jørgen, Fortune, Christien, Bradley, Joshua, Belcher, John, Hearne, Edward, Ogunyemi, Foluwakemi, Timoney, Richard, Prescott, Daniel, Bain, Hamish D.C., Bangi, Tasneem, Zaman, Mahvash, Wong, Christopher, Ashworth, Anthony, Thorpe, Helen, Egdell, Robin, McIntosh, Jerome, Irwin, Bruce R., Clark, David, Devereux, Graham, Quint, Jennifer K., Barraclough, Richard, Schmitt, Matthias, and Miller, Christopher A.
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- 2021
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31. Asthma and COPD versus phenotypic traits: Toward precision medicine in chronic airway disease
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Vedel-Krogh, Signe, Nielsen, Sune Fallgaard, Nordestgaard, Børge Grønne, Lange, Peter, and Vestbo, Jørgen
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- 2021
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32. Supernormal lung function and risk of COPD: A contemporary population-based cohort study
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Çolak, Yunus, Nordestgaard, Børge G., Lange, Peter, Vestbo, Jørgen, and Afzal, Shoaib
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- 2021
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33. Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.
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Busch, Robert, Hobbs, Brian D, Zhou, Jin, Castaldi, Peter J, McGeachie, Michael J, Hardin, Megan E, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Yim, Jae-Joon, Kim, Woo Jin, Kim, Deog K, Agusti, Alvar, Make, Barry J, Crapo, James D, Calverley, Peter M, Donner, Claudio F, Lomas, David A, Wouters, Emiel F, Vestbo, Jørgen, Tal-Singer, Ruth, Bakke, Per, Gulsvik, Amund, Litonjua, Augusto A, Sparrow, David, Paré, Peter D, Levy, Robert D, Rennard, Stephen I, Beaty, Terri H, Hokanson, John, Silverman, Edwin K, Cho, Michael H, National Emphysema Treatment Trial Genetics, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points, International COPD Genetics Network, and COPDGene Investigators
- Subjects
National Emphysema Treatment Trial Genetics ,Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points ,International COPD Genetics Network ,COPDGene Investigators ,Humans ,Pulmonary Disease ,Chronic Obstructive ,Genetic Predisposition to Disease ,Respiratory Function Tests ,Risk Factors ,Aged ,Middle Aged ,Female ,Male ,Genome-Wide Association Study ,alpha-1 antitrypsin ,chronic obstructive pulmonary disease ,genetic epidemiology ,genetic risk factors ,genetic risk score ,Chronic Obstructive Pulmonary Disease ,Lung ,Clinical Research ,Genetics ,Prevention ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Respiratory ,Cardiorespiratory Medicine and Haematology ,Respiratory System - Abstract
The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained by recognized genetic risk factors identified as achieving genome-wide significance. In addition, the combined contribution of genetic variation to COPD risk has not been fully explored. We sought to determine: (1) whether studies of variants from previous studies of COPD or lung function in a larger sample could identify additional associated variants, particularly for severe COPD; and (2) the impact of genetic risk scores on COPD. We genotyped 3,346 single-nucleotide polymorphisms (SNPs) in 2,588 cases (1,803 severe COPD) and 1,782 control subjects from four cohorts, and performed association testing with COPD, combining these results with existing genotyping data from 6,633 cases (3,497 severe COPD) and 5,704 control subjects. In addition, we developed genetic risk scores from SNPs associated with lung function and COPD and tested their discriminatory power for COPD-related measures. We identified significant associations between SNPs near PPIC (P = 1.28 × 10-8) and PPP4R4/SERPINA1 (P = 1.01 × 10-8) and severe COPD; the latter association may be driven by recognized variants in SERPINA1. Genetic risk scores based on SNPs previously associated with COPD and lung function had a modest ability to discriminate COPD (area under the curve, ∼0.6), and accounted for a mean 0.9-1.9% lower forced expiratory volume in 1 second percent predicted for each additional risk allele. In a large genetic association analysis, we identified associations with severe COPD near PPIC and SERPINA1. A risk score based on combining genetic variants had modest, but significant, effects on risk of COPD and lung function.
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- 2017
34. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
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Hobbs, Brian D, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María Soler, Wain, Louise V, Hall, Ian P, Jackson, Victoria E, Wyss, Annah B, London, Stephanie J, North, Kari E, Franceschini, Nora, Strachan, David P, Beaty, Terri H, Hokanson, John E, Crapo, James D, Castaldi, Peter J, Chase, Robert P, Bartz, Traci M, Heckbert, Susan R, Psaty, Bruce M, Gharib, Sina A, Zanen, Pieter, Lammers, Jan W, Oudkerk, Matthijs, Groen, HJ, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen I, Vestbo, Jørgen, Timens, Wim, Paré, Peter D, Latourelle, Jeanne C, Dupuis, Josée, O'Connor, George T, Wilk, Jemma B, Kim, Woo Jin, Lee, Mi Kyeong, Oh, Yeon-Mok, Vonk, Judith M, de Koning, Harry J, Leng, Shuguang, Belinsky, Steven A, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen S, Barr, R Graham, Sparrow, David, Litonjua, Augusto A, Bakke, Per, Gulsvik, Amund, Lahousse, Lies, Brusselle, Guy G, Stricker, Bruno H, Uitterlinden, André G, Ampleford, Elizabeth J, Bleecker, Eugene R, Woodruff, Prescott G, Meyers, Deborah A, Qiao, Dandi, Lomas, David A, Yim, Jae-Joon, Kim, Deog Kyeom, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Hardin, Megan, Fingerlin, Tasha E, Schwartz, David A, Postma, Dirkje S, MacNee, William, Tobin, Martin D, Silverman, Edwin K, Boezen, H Marike, and Cho, Michael H
- Subjects
Biological Sciences ,Genetics ,Chronic Obstructive Pulmonary Disease ,Lung ,Human Genome ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Respiratory ,Adult ,Aged ,Aged ,80 and over ,Alleles ,Asthma ,Female ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Phenotype ,Polymorphism ,Single Nucleotide ,Pulmonary Disease ,Chronic Obstructive ,Pulmonary Fibrosis ,Risk Factors ,Smoking ,COPDGene Investigators ,ECLIPSE Investigators ,LifeLines Investigators ,SPIROMICS Research Group ,International COPD Genetics Network Investigators ,UK BiLEVE Investigators ,International COPD Genetics Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10-6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.
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- 2017
35. Machine Learning and Prediction of All-Cause Mortality in COPD
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Moll, Matthew, Qiao, Dandi, Regan, Elizabeth A., Hunninghake, Gary M., Make, Barry J., Tal-Singer, Ruth, McGeachie, Michael.J., Castaldi, Peter J., San Jose Estepar, Raul, Washko, George R., Wells, James M., LaFon, David, Strand, Matthew, Bowler, Russell P., Han, MeiLan.K., Vestbo, Jorgen, Celli, Bartolome, Calverley, Peter, Crapo, James, Silverman, Edwin K., Hobbs, Brian D., and Cho, Michael H.
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- 2020
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36. The many faces of copd in real life: a longitudinal analysis of the novelty cohort
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Agusti, Alvar, primary, Hughes, Rod, additional, Rapsomaki, Eleni, additional, Make, Barry, additional, del Olmo, Ricardo, additional, Papi, Alberto, additional, Price, David, additional, Benton, Laura, additional, Franzen, Stefan, additional, Vestbo, Jørgen, additional, and Mullerova, Hana, additional
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- 2023
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37. Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments
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Mathioudakis, Alexander G., primary, Fally, Markus, additional, Hansel, Jan, additional, Robey, Rebecca C., additional, Haseeb, Faiuna, additional, Williams, Thomas, additional, Kouta, Ahmed, additional, Welte, Tobias, additional, Wootton, Dan G., additional, Clarke, Mike, additional, Waterer, Grant, additional, Dark, Paul, additional, Williamson, Paula R., additional, Vestbo, Jørgen, additional, Felton, Timothy W., additional, Aliberti, Stefano, additional, Barac, Aleksandra, additional, Blasi, Francesco, additional, Chastre, Jean, additional, Ciloniz, Catia, additional, Dimopoulos, George, additional, Gramegna, Andrea, additional, Mathioudakis, Alexander G., additional, Polverino, Eva, additional, Roger, Claire, additional, Rovina, Nikoletta, additional, Stolz, Daiana, additional, and van Wouter, Geffen, additional
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- 2023
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38. Prevalence and clinical implications of respiratory viruses in asthma during stable disease state and acute attacks: Protocol for a meta-analysis
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Alimani, Gioulinta S., primary, Ananth, Sachin, additional, Boccabella, Cristina, additional, Khaleva, Ekaterina, additional, Roberts, Graham, additional, Papadopoulos, Nikolaos G., additional, Kosmidis, Chris, additional, Vestbo, Jørgen, additional, Papageorgiou, Effie, additional, Beloukas, Apostolos, additional, and Mathioudakis, Alexander G., additional
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- 2023
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39. Rethinking Blood Eosinophils for Assessing ICS Response in COPD: A Post-Hoc Analysis from FLAME
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Mathioudakis, Alexander G., primary, Bate, Sebastian, additional, Sivapalan, Pradeesh, additional, Jensen, Jens-Ulrik, additional, Singh, Dave, additional, and Vestbo, Jørgen, additional
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- 2023
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40. Effect of different corticosteroid regimes for hospitalised patients with exacerbated COPD: pooled analysis of individual participant data from the REDUCE and CORTICO-COP trials
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Sivapalan, Pradeesh, Rutishauser, Jonas, Ulrik, Charlotte Suppli, Leuppi, Jörg D., Pedersen, Lars, Mueller, Beat, Eklöf, Josefin, Biering-Sørensen, Tor, Gottlieb, Vibeke, Armbruster, Karin, Janner, Julie, Moberg, Mia, Lapperre, Therese S., Nielsen, Thyge L., Browatzki, Andrea, Mathioudakis, Alexander, Vestbo, Jørgen, Schüetz, Philipp, and Jensen, Jens-Ulrik
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- 2021
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41. End-product of fibrinogen is elevated in emphysematous chronic obstructive pulmonary disease and is predictive of mortality in the ECLIPSE cohort
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Manon-Jensen, Tina, Langholm, Lasse L., Rønnow, Sarah Rank, Karsdal, Morten Asser, Tal-Singer, Ruth, Vestbo, Jørgen, Leeming, Diana Julie, Miller, Bruce E., and Bülow Sand, Jannie Marie
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- 2019
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42. E-cigarettes, heated tobacco and other novel nicotine-containing products: a help to smokers or a public health threat?
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Pisinger, Charlotta, primary, Katsaounou, Paraskevi, additional, Ravara, Sofia Belo, additional, and Vestbo, Jørgen, additional
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- 2021
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43. Real-World Data and Randomised Controlled Trials: The Salford Lung Study
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Leather, David A., Jones, Rupert, Woodcock, Ashley, Vestbo, Jørgen, Jacques, Loretta, and Thomas, Mike
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- 2020
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44. Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease
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McDonald, Merry-Lynn N, Cho, Michael H, Sørheim, Inga-Cecilie, Lutz, Sharon M, Castaldi, Peter J, Lomas, David A, Coxson, Harvey O, Edwards, Lisa D, MacNee, William, Vestbo, Jørgen, Yates, Julie C, Agusti, Alvar, Calverley, Peter MA, Celli, Bartolome, Crim, Courtney, Rennard, Stephen I, Wouters, Emiel FM, Bakke, Per, Tal-Singer, Ruth, Miller, Bruce E, Gulsvik, Amund, Casaburi, Richard, Wells, J Michael, Regan, Elizabeth A, Make, Barry J, Hokanson, John E, Lange, Christoph, Crapo, James D, Beaty, Terri H, Silverman, Edwin K, and Hersh, Craig P
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Lung ,Prevention ,Clinical Research ,Chronic Obstructive Pulmonary Disease ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Respiratory ,Black or African American ,Aged ,Aged ,80 and over ,Chromosomes ,Human ,Pair 15 ,Female ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Hypoxia ,Male ,Middle Aged ,Oximetry ,Oxygen ,Polymorphism ,Single Nucleotide ,Prognosis ,Pulmonary Disease ,Chronic Obstructive ,Rest ,White People ,chronic obstructive pulmonary disease ,hypoxemia ,pulse oximetry ,genome-wide association study ,oxygen saturation ,Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators ,Cardiorespiratory Medicine and Haematology ,Respiratory System ,Biochemistry and cell biology ,Cardiovascular medicine and haematology - Abstract
Hypoxemia is a major complication of chronic obstructive pulmonary disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among patients with COPD. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation (as measured by pulse oximetry [Spo2]) in subjects with COPD, we performed a GWAS of Spo2 in two large, well characterized COPD populations: COPDGene, including both the non-Hispanic white (NHW) and African American (AA) groups, and Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). We identified several suggestive loci (P < 1 × 10(-5)) associated with Spo2 in COPDGene in the NHW (n = 2810) and ECLIPSE (n = 1758) groups, and two loci on chromosomes 14 and 15 in the AA group (n = 820) from COPDGene achieving a level of genome-wide significance (P < 5 × 10(-8)). The chromosome 14 single-nucleotide polymorphism, rs6576132, located in an intergenic region, was nominally replicated (P < 0.05) in the NHW group from COPDGene. The chromosome 15 single-nucleotide polymorphisms were rare in subjects of European ancestry, so the results could not be replicated. The chromosome 15 region contains several genes, including TICRR and KIF7, and is proximal to RHCG (Rh family C glyocoprotein gene). We have identified two loci associated with resting oxygen saturation in AA subjects with COPD, and several suggestive regions in subjects of European descent with COPD. Our study highlights the importance of investigating the genetics of complex traits in different racial groups.
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- 2014
45. Prognosis of COPD depends on severity of exacerbation history: A population-based analysis
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Çolak, Yunus, Afzal, Shoaib, Marott, Jacob L., Nordestgaard, Børge G., Vestbo, Jørgen, Ingebrigtsen, Truls S., and Lange, Peter
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- 2019
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46. Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial
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Sivapalan, Pradeesh, Lapperre, Therese S, Janner, Julie, Laub, Rasmus R, Moberg, Mia, Bech, Charlotte S, Eklöf, Josefin, Holm, Freja S, Armbruster, Karin, Sivapalan, Praleene, Mosbech, Christiane, Ali, Aras K M, Seersholm, Niels, Wilcke, Jon T, Brøndum, Eva, Sonne, Tine P, Rønholt, Finn, Andreassen, Helle F, Ulrik, Charlotte S, Vestbo, Jørgen, and Jensen, Jens-Ulrik S
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- 2019
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47. Association of Cardiovascular Disease With Respiratory Disease
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Carter, Paul, Lagan, Jakub, Fortune, Christien, Bhatt, Deepak L., Vestbo, Jørgen, Niven, Robert, Chaudhuri, Nazia, Schelbert, Erik B., Potluri, Rahul, and Miller, Christopher A.
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- 2019
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48. Benefit and safety of fluticasone furoate/vilanterol in the Salford Lung Study in chronic obstructive pulmonary disease (SLS COPD) according to baseline patient characteristics and treatment subgroups
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Bakerly, Nawar Diar, Woodcock, Ashley, Collier, Susan, Leather, David A., New, John P., Crawford, Jodie, Harvey, Catherine, Vestbo, Jørgen, and Boucot, Isabelle
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- 2019
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49. The many faces of COPD in real life: a longitudinal analysis of the NOVELTY cohort.
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Agustí, Alvar, Hughes, Rod, Rapsomaki, Eleni, Make, Barry, del Olmo, Ricardo, Papi, Alberto, Price, David, Benton, Laura, Franzen, Stefan, Vestbo, Jørgen, and Mullerova, Hana
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- 2024
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50. Inhaled versus systemic corticosteroids for acute exacerbations of COPD: a systematic review and meta-analysis.
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Papadopoulou, Efthymia, Safar, Sulaiman Bin, Khalil, Ali, Hansel, Jan, Ran Wang, Corlateanu, Alexandru, Kostikas, Konstantinos, Tryfon, Stavros, Vestbo, Jørgen, and Mathioudakis, Alexander G.
- Abstract
This meta-analysis compares the efficacy and safety of inhaled versus systemic corticosteroids for COPD exacerbations. Following a pre-registered protocol, we appraised eligible randomised controlled trials (RCTs) according to Cochrane methodology, performed random-effects meta-analyses for all outcomes prioritised in the European Respiratory Society COPD core outcome set and rated the certainty of evidence as per Grading of Recommendations Assessment, Development and Evaluation methodology. We included 20 RCTs totalling 2140 participants with moderate or severe exacerbations. All trials were at high risk of methodological bias. Low-certainty evidence did not reveal significant differences between inhaled and systemic corticosteroids for treatment failure rate (relative risk 1.75, 95% CI 0.76–4.02, n=569 participants); breathlessness (mean change: standardised mean difference (SMD) −0.11, 95% CI −0.36– 0.15, n=239; post-treatment scores: SMD −0.18, 95% CI −0.41–0.05, n=293); serious adverse events (relative risk 1.47, 95% CI 0.56–3.88, n=246); or any other efficacy outcomes. Moderate-certainty evidence implied a tendency for fewer adverse events with inhaled compared to systemic corticosteroids (relative risk 0.80, 95% CI 0.64–1.0, n=480). Hyperglycaemia and oral fungal infections were observed more frequently with systemic and inhaled corticosteroids, respectively. Limited available evidence suggests potential noninferiority of inhaled to systemic corticosteroids in COPD exacerbations. Appropriately designed and powered RCTs are warranted to confirm these findings. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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