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1. Female Sex and Angiotensin-Converting Enzyme (ACE) Insertion/Deletion Polymorphism Amplify the Effects of Adiposity on Blood Pressure

Author

Chiriacò, Martina, primary, Tricò, Domenico, additional, Leonetti, Simone, additional, Petrie, John R., additional, Balkau, Beverley, additional, Højlund, Kurt, additional, Pataky, Zoltan, additional, Nilsson, Peter M, additional, Natali, Andrea, additional, Heine, R.J., additional, Dekker, J., additional, de Rooij, S., additional, Nijpels, G., additional, Boorsma, W., additional, Mitrakou, A., additional, Tournis, S., additional, Kyriakopoulou, K., additional, Thomakos, P., additional, Lalic, N., additional, Lalic, K., additional, Jotic, A., additional, Lukic, L., additional, Civcic, M., additional, Nolan, J., additional, Yeow, T.P., additional, Murphy, M., additional, DeLong, C., additional, Neary, G., additional, Colgan, M.P., additional, Hatunic, M., additional, Konrad, T., additional, Böhles, H., additional, Fuellert, S., additional, Baer, F., additional, Zuchhold, H., additional, Golay, A., additional, Harsch Bobbioni, E., additional, Barthassat, V., additional, Makoundou, V., additional, Lehmann, T.N.O., additional, Merminod, T., additional, Perry, C., additional, Neary, F., additional, MacDougall, C., additional, Shields, K., additional, Malcolm, L., additional, Laakso, M., additional, Salmenniemi, U., additional, Aura, A., additional, Raisanen, R., additional, Ruotsalainen, U., additional, Sistonen, T., additional, Laitinen, M., additional, Saloranta, H., additional, Coppack, S.W., additional, McIntosh, N., additional, Ross, J., additional, Pettersson, L., additional, Khadobaksh, P., additional, Laville, M., additional, Bonnet, F., additional, Brac de la Perriere, A., additional, Louche-Pelissier, C., additional, Maitrepierre, C., additional, Peyrat, J., additional, Beltran, S., additional, Serusclat, A., additional, Gabriel, R., additional, Sánchez, E.M., additional, Carraro, R., additional, Friera, A., additional, Novella, B., additional, Nilsson, P., additional, Persson, M., additional, Östling, G., additional, Melander, O., additional, Burri, P., additional, Piatti, P.M., additional, Monti, L.D., additional, Setola, E., additional, Galluccio, E., additional, Minicucci, F., additional, Colleluori, A., additional, Walker, M., additional, Ibrahim, I.M., additional, Jayapaul, M., additional, Carman, D., additional, Ryan, C., additional, Short, K., additional, McGrady, Y., additional, Richardson, D., additional, Beck-Nielsen, H., additional, Staehr, P., additional, Vestergaard, V., additional, Olsen, C., additional, Hansen, L., additional, Bolli, G.B., additional, Porcellati, F., additional, Fanelli, C., additional, Lucidi, P., additional, Calcinaro, F., additional, Saturni, A., additional, Ferrannini, E., additional, Muscelli, E., additional, Pinnola, S., additional, Kozakova, M., additional, Casolaro, A., additional, Astiarraga, B.D., additional, Mingrone, G., additional, Guidone, C., additional, Favuzzi, A., additional, Di Rocco, P., additional, Anderwald, C., additional, Bischof, M., additional, Promintzer, M., additional, Krebs, M., additional, Mandl, M., additional, Hofer, A., additional, Luger, A., additional, Waldhäusl, W., additional, Roden, M., additional, Dekker, J.M., additional, Mari, A., additional, Petrie, J., additional, Gaffney, P., additional, Boran, G., additional, Kok, A., additional, Patel, S., additional, Gastaldelli, A., additional, Ciociaro, D., additional, Guillanneuf, M.T., additional, Mhamdi, L., additional, Landucci, L., additional, Hills, S., additional, Mota, L., additional, Pacini, G., additional, Cavaggion, C., additional, Tura, A., additional, and Hills, S.A., additional

Published
2022
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3. Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Author

Kozakova, M. Gastaldelli, A. Morizzo, C. Højlund, K. Nilssson, P.M. Ferrannini, E. Heine, R.J. Dekker, J. de Rooij, S. Nijpels, G. Boorsma, W. Kok, A. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Gaffney, P. Boran, G. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Bobbioni, E.H. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Petrie (now Dundee), J.R. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Balkau, B. Mhamdi, L. Guillanneuf, M.T. Laville, M. Bonnet, F. Brac de la Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, E.M. Carraro, R. Friera, A. Novella, B. Nilssone, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Patel, S. Beck-Nielsen, H. Staehr, P. Hojlundd, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferranninia, E. Natali, A. Muscelli, E. Pinnola, S. Kozakovaa, M. Hills, S.A. Landucci, L. Mota, L. Gastaldelli, A. Ciociaro, D. Mari, A. Pacini, G. Cavaggion, C. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Palombo, C. RISC Investigators

Abstract

Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and

Published
2021

4. One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort

Author

Manco, Melania, Mari, Andrea, Petrie, John, Mingrone, Geltrude, Balkau, Beverley, Amsterdam, for the EGIR-RISC study group., Heine, Rj, Dekker, J, S de Rooij, Nijpels, G, W Boorsma Athens, Greece:, A Mitrakou, Tournis, S, Kyriakopoulou, K, P Thomakos Belgrade, Serbia:, N Lalic, Lalic, K, Jotic, A, Lukic, L, M Civcic Dublin, Ireland:, J Nolan, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, M Hatunic Frankfurt, Germany:, T Konrad, Böhles, H, Fuellert, S, Baer, F, H Zuchhold Geneva, Switzerland:, A Golay, E Harsch Bobbioni, Barthassat, V, Makoundou, V, Tno, Lehmann, T Merminod Glasgow, Scotland, UK: JR Petrie, Perry, C, Neary, F, Macdougall, C, Shields, K, L Malcolm Kuopio, Finland:, M Laakso, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, H Saloranta London, England, UK: SW Coppack, Mcintosh, N, Ross, J, Pettersson, L, P Khadobaksh Lyon, France:, M Laville, F Bonnet (now Rennes), A Brac de la Perriere, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, A Serusclat Madrid, Spain:, R Gabriel, Sánchez, Em, Carraro, R, Friera, A, B Novella Malmö, Sweden (1):, P Nilsson, Persson, M, G Östling (2):, O Melander, P Burri Milan, Italy: PM Piatti, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, A Colleluori Newcastle-upon-Tyne, Uk:, M Walker, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, D Richardson Odense, Denmark:, H Beck-Nielsen, Staehr, P, Højlund, K, Vestergaard, V, Olsen, C, L Hansen Perugia, Italy: GB Bolli, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, A Saturni Pisa, Italy:, E Ferrannini, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, BD Astiarraga Rome, Italy:, G Mingrone, Guidone, C, Favuzzi, A, P Di Rocco Vienna, Austria:, C Anderwald, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, and Roden, M

Subjects
Post-load glucose, Adult, Male, Blood Glucose, 0301 basic medicine, Diagnostic criteria, Endocrinology, Diabetes and Metabolism, Physiology, 030209 endocrinology & metabolism, Prediabetic State, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Research Letter, Internal Medicine, medicine, Humans, Prediabetes, Plasma glucose, Glucose tolerance test, Post-challenge glucose, Prediabetes phenotype, Progression, medicine.diagnostic_test, business.industry, Fasting, Female, Glucose Tolerance Test, Middle Aged, Settore MED/13 - ENDOCRINOLOGIA, Human physiology, medicine.disease, Diabetes and Metabolism, 030104 developmental biology, Cohort, business
Abstract

The affiliation details for Geltrude Mingrone are corrected below.

Published
2018
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5. Budesonide treatment of collagenous colitis: a randomised, double blind, placebo controlled trial with morphometric analysis. (Inflammation and Inflammatory Bowel Disease)

Author

Bonderup, O.K., Hansen, J.B., Birket-Smith, L., Vestergaard, V., Teglbjaerg, P.S., and Fallingborg, J.

Subjects
AstraZeneca PLC -- Product information, Budesonide -- Evaluation -- Product information -- Product/service Evaluations, Colitis -- Drug therapy -- Product information, Pharmaceutical industry -- Product information, Health, Entocort (Medication) -- Evaluation -- Product information -- Product/service Evaluations
Abstract

Background: Collagenous colitis is characterised by diarrhoea, lymphocytic inflammation, and a thickened subepithelial collagen layer in the colorectal mucosa. No standard treatment of the disease is established. Aims: To investigate [...]

Published
2003

6. Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Author

Kozakova, M., Gastaldelli, A., Morizzo, C., Hojlund, K., Nilssson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., de Rooij, S., Nijpels, G., Boorsma, W., Kok, A., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Gaffney, P., Boran, G., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie (now Dundee), J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Balkau, B., Mhamdi, L., Guillanneuf, M. T., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilssone, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Patel, S., Beck-Nielsen, H., Staehr, P., Hojlundd, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferranninia, E., Natali, A., Muscelli, E., Pinnola, S., Kozakovaa, M., Hills, S. A., Landucci, L., Mota, L., Ciociaro, D., Mari, A., Pacini, Giovanni, Cavaggion, C., Mingrone, Geltrude, Guidone, C., Favuzzi, Angela Maria Rita, Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Palombo, C., Pacini G., Mingrone G. (ORCID:0000-0003-2021-528X), Favuzzi A., Kozakova, M., Gastaldelli, A., Morizzo, C., Hojlund, K., Nilssson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., de Rooij, S., Nijpels, G., Boorsma, W., Kok, A., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Gaffney, P., Boran, G., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie (now Dundee), J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Balkau, B., Mhamdi, L., Guillanneuf, M. T., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilssone, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Patel, S., Beck-Nielsen, H., Staehr, P., Hojlundd, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferranninia, E., Natali, A., Muscelli, E., Pinnola, S., Kozakovaa, M., Hills, S. A., Landucci, L., Mota, L., Ciociaro, D., Mari, A., Pacini, Giovanni, Cavaggion, C., Mingrone, Geltrude, Guidone, C., Favuzzi, Angela Maria Rita, Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Palombo, C., Pacini G., Mingrone G. (ORCID:0000-0003-2021-528X), and Favuzzi A.

Abstract

Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension.

Published
2020

7. Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis

Author

Trico, D, Mengozzi, A, Nesti, L, Hatunic, M, Sanchez, Rg, Konrad, T, Lalic, K, Lalic, Nm, Mari, A, Natali, A, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Bohles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, Eh, Barthassat, V, Makoundou, V, Lehmann, Tno, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere, Ab, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sanchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, I, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck-Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, Saturni, A, Ferrannini, E, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhausl, W, Roden, M, Balkau, B, Dekker, Jm, Petrie, J, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Tura, A, Hills, Sa, and Mota, L.

Subjects
Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Subcutaneous adipose tissue, Endocrinology, Diabetes and Metabolism, Adipose tissue, 030209 endocrinology & metabolism, Carbohydrate metabolism, Palmitate, NEFA, Fatty Acids, Monounsaturated, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Insulin-Secreting Cells, Internal medicine, Adipokine, Internal Medicine, medicine, Humans, Palmitoleic acid, Longitudinal Studies, Monounsaturated fatty acid, Lipokine, Beta cell function, Glucose tolerance, Metabolism, Glucose Tolerance Test, Middle Aged, medicine.disease, Insulin sensitivity, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, chemistry, Body Composition, Female, Insulin Resistance, Hormone
Abstract

Experimental studies suggest that the fatty acid palmitoleate may act as an adipocyte-derived lipid hormone (or ‘lipokine’) to regulate systemic metabolism. We investigated the relationship of circulating palmitoleate with insulin sensitivity, beta cell function and glucose tolerance in humans. Plasma NEFA concentration and composition were determined in non-diabetic individuals from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study cohort at baseline (n = 1234) and after a 3 year follow-up (n = 924). Glucose tolerance, insulin secretion and beta cell function were assessed during an OGTT. Whole-body insulin sensitivity was measured by a hyperinsulinaemic–euglycaemic clamp (M/I) and OGTT (oral glucose insulin sensitivity index [OGIS]). The liver insulin resistance index was calculated using clinical and biochemical data. Body composition including fat mass was determined by bioelectrical impedance. Circulating palmitoleate was proportional to fat mass (r = 0.21, p < 0.0001) and total NEFA levels (r = 0.19, p < 0.0001). It correlated with whole-body insulin sensitivity (M/I: standardised regression coefficient [std. β] = 0.16, p < 0.0001), liver insulin resistance (std. β = −0.14, p < 0.0001), beta cell function (potentiation: std. β = 0.08, p = 0.045) and glucose tolerance (2 h glucose: std. β = −0.24, p < 0.0001) after adjustment for age, sex, BMI, adiposity and other NEFA. High palmitoleate concentrations prevented the decrease in insulin sensitivity associated with excess palmitate (p = 0.0001). In a longitudinal analysis, a positive independent relationship was observed between changes in palmitoleate and insulin sensitivity over time (std. β = 0.07, p = 0.04). We demonstrated that plasma palmitoleate is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals. These results support the role of palmitoleate as a beneficial lipokine released by adipose tissue to prevent the negative effects of adiposity and excess NEFA on systemic glucose metabolism.

Published
2019

9. Identification of mutations in SDR9C7 in six families with autosomal recessive congenital ichthyosis

Author

Hotz, A., Fagerberg, C., Vahlquist, Anders, Bygum, A., Törmä, Hans, Rauschendorf, M-A, Zhang, Hanqian, Heinz, L., Bourrat, E., Hausser, I., Vestergaard, V., Dragomir, Anca, Zimmer, A. D., Fischer, J., Hotz, A., Fagerberg, C., Vahlquist, Anders, Bygum, A., Törmä, Hans, Rauschendorf, M-A, Zhang, Hanqian, Heinz, L., Bourrat, E., Hausser, I., Vestergaard, V., Dragomir, Anca, Zimmer, A. D., and Fischer, J.

Published
2018
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10. Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

Author

Kozakova, M, Natali, A, Dekker, J, Beck Nielsen, H, Laakso, M, Nilsson, P, Balkau, B, Ferrannini, E, Heine, Rj, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie Dundee JR, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, Filippo, Saturni, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, Dekker, Ferrannini, Mari, A, Natali, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Blood Glucose, Carotid Artery Diseases, Male, medicine.medical_specialty, Adipokine, Carotid Intima-Media Thickness, Risk Assessment, Sensitivity and Specificity, Cohort Studies, Insulin resistance, Age Distribution, Adipokines, Diabetes mellitus, Internal medicine, medicine.artery, medicine, Humans, Common carotid artery, cardiovascular diseases, Sex Distribution, Retrospective Studies, business.industry, Incidence, Fatty Acids, Insulin sensitivity, Cholesterol, LDL, Glucose Tolerance Test, Middle Aged, medicine.disease, Prognosis, Endocrinology, Intima-media thickness, Cardiovascular Diseases, Cohort, Glucose Clamp Technique, cardiovascular system, Female, Insulin Resistance, Cardiology and Cardiovascular Medicine, business, Dyslipidemia
Abstract

Objective— Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results— We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intima-media thickness in the common carotid artery (CCA-IMT) was significantly higher ( P P Conclusions— In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.

Published
2013
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11. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

Author

de Rooij SR, Dekker, Jm, Kozakova, M, Mitrakou, A, Melander, O, Gabriel, R, Guidone, C, Højlund, K, Murphy, Ms, Nijpels, G, Dekker, J, de Rooij, S, Boorsma, P, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Raisanen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, S, Sánchez, Me, Carraro, R, Friera, A, Perez, S, Nilsson, P, Persson, M, Ostling, G, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofe, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Mota, Epidemiology and Data Science, General practice, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cohort Studies, Endocrinology, Insulin resistance, Internal medicine, Prevalence, medicine, Hyperinsulinemia, Humans, Insulin, Ultrasonography, Metabolic Syndrome, Glucose tolerance test, medicine.diagnostic_test, business.industry, Metabolic Syndrome X, Fasting, General Medicine, Odds ratio, Glucose Tolerance Test, Middle Aged, Glucose clamp technique, medicine.disease, Cardiovascular Diseases, Europe, Female, Glucose Clamp Technique, Insulin Resistance, Tunica Media, Intima-media thickness, Metabolic syndrome, business
Abstract

ObjectiveFasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis.Design and methodsThe Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30–60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis.ResultsFasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8–10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6–9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3–4.7, adjusted for fasting insulin) in men and 1.6 (0.8–3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women.ConclusionsFasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity.

Published
2009
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12. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Author

Gastaldelli, A., Kozakova, M., Hojlund, K., Flyvbjerg, A., Favuzzi, A., Mitrakou, A., Balkau, B., Heine, R. J., Dekker, J., Nijpels, G., Boorsma, W., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Harsch Bobbioni, E., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Khadobaksh, P., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Oostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferrannini, E., Natali, A., Muscelli, E., Pinnola, S., Mingrone, G., Guidone, C., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhaausl, W., Roden, M., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., Mota, L., Epidemiology and Data Science, Internal medicine, General practice, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Male, medicine.medical_specialty, Carotid Artery, Common, Coronary Disease, Impaired glucose tolerance, Framingham Heart Study, Insulin resistance, Risk Factors, Internal medicine, Diabetes mellitus, Humans, Medicine, Prospective Studies, Risk factor, Ultrasonography, Hepatology, Adiponectin, business.industry, Fatty liver, Middle Aged, Atherosclerosis, medicine.disease, Common, Europe, Fatty Liver, Endocrinology, Female, Insulin Resistance, Intima-media thickness, Carotid Artery, business
Abstract

Udgivelsesdato: 2009-May Patients with fatty liver (FL) disease have a high risk of developing diabetes and cardiovascular diseases. The aim was to evaluate the association between FL, insulin resistance (IR), coronary heart disease (CHD) risk, and early atherosclerosis in a large European population (RISC Study). In 1,307 nondiabetic subjects (age 30-60 years) recruited at 19 centers, we evaluated liver enzymes, lipids, insulin sensitivity (by euglycemic-hyperinsulinemic clamp), glucose tolerance (by 75 g oral glucose tolerance test), carotid atherosclerosis as intima media thickness (IMT), CHD risk by the Framingham Heart study prediction score, and physical activity (by accelerometer). The presence of FL was estimated using the fatty liver index (FLI; >60, likelihood >78% presence FL; FLI 91% absence of FL). Subjects were divided into three groups: G1: FLI 60 (n = 234), G2: intermediate group (n = 465). Compared to G1, G3 included more men (70% versus 24%) and people with impaired glucose tolerance (23% versus 5%). IMT increased with FLI (G3 = 0.64 +/- 0.08 versus G1 = 0.58 +/- 0.08 mm, P < 0.0001). FLI was associated with increased CHD risk (r = 0.48), low-density lipoprotein cholesterol (r = 0.33), alanine aminotransferase (r = 0.48), aspartate aminotransferase (r = 0.25), systolic blood pressure (r = 0.39) and IMT (r = 0.30), and reduced insulin sensitivity (r = -0.43), high-density lipoprotein cholesterol (r = -0.50), adiponectin (r = -0.42), and physical activity (r = -0.16, all P < 0.0001). The correlations hold also in multivariate analysis after adjusting for age, gender, and recruiting center. Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI.

Published
2009
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13. Identification of mutations in SDR9C7 in six families with autosomal recessive congenital ichthyosis

Author

Hotz, A., primary, Fagerberg, C., additional, Vahlquist, A., additional, Bygum, A., additional, Törmä, H., additional, Rauschendorf, M.-A., additional, Zhang, H., additional, Heinz, L., additional, Bourrat, E., additional, Hausser, I., additional, Vestergaard, V., additional, Dragomir, A., additional, Zimmer, A.D., additional, and Fischer, J., additional

Published
2018
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14. Obesity and carotid artery remodeling

Author

Kozakova, M., Palombo, C., Morizzo, C., Hojlund, K., Hatunic, M., Balkau, B., Nilsson, P. M., Ferrannini, E., Heine, R. J., Dekker, J., De Rooij, S., Nijpels, G., Boorsma, W., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Konrad, T., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Angel, ROSS JOHN, Pettersson, L., Khadobaksh, P., Laville, M., Bonnet, F., De La Perriere, A. B., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Natali, A., Muscelli, E., Pinnola, S., Mingrone, G., Guidone, C., Favuzzi, A., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Gastaldelli, A., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Mota, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., Internal medicine, Dermatology, Epidemiology and Data Science, CCA - Immuno-pathogenesis, EMGO - Lifestyle, overweight and diabetes, and General practice

Subjects
Pathology, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Carotid arteries, Carotid remodeling, Hemodynamics, Stroke volume, medicine.disease, Obesity, Obesity, Carotid remodeling, Ultrasound, Blood pressure, Diabetes mellitus, Ultrasound, Internal Medicine, medicine, cardiovascular system, Cardiac and Cardiovascular Systems, Original Article, cardiovascular diseases, Metabolic syndrome, business, Body mass index
Abstract

Background/Objective: The present study tested the hypothesis that obesity-related changes in carotid intima-media thickness (IMT) might represent not only preclinical atherosclerosis but an adaptive remodeling meant to preserve circumferential wall stress (CWS) in altered hemodynamic conditions characterized by body size-dependent increase in stroke volume (SV) and blood pressure (BP). Subjects/Methods: Common carotid artery (CCA) luminal diameter (LD), IMT and CWS were measured in three different populations in order to study: (A) cross-sectional associations between SV, BP, anthropometric parameters and CCA LD (266 healthy subjects with wide range of body weight (24–159 kg)); (B) longitudinal associations between CCA LD and 3-year IMT progression rate (ΔIMT; 571 healthy non-obese subjects without increased cardiovascular (CV) risk); (C) the impact of obesity on CCA geometry and CWS (88 obese subjects without CV complications and 88 non-obese subjects matched for gender and age). Results: CCA LD was independently associated with SV that was determined by body size. In the longitudinal study, baseline LD was an independent determinant of ΔIMT, and ΔIMT of subjects in the highest LD quartile was significantly higher (28±3 μm) as compared with those in the lower quartiles (8±3, 16±4 and 16±3 μm, P=0.001, PP=0.01, respectively). In addition, CCA CWS decreased during the observational period in the highest LD quartile (from 54.2±8.6 to 51.6±7.4 kPa, PPP=0.05) due to a significant increase in IMT (P=0.005 after adjustment for confounders). Conclusions: Our findings suggest that in obese subjects, the CCA wall thickens to compensate the luminal enlargement caused by body size-induced increase in SV, and therefore, to normalize the wall stress. CCA diameter in obesity could represent an additional biomarker, depicting the impact of altered hemodynamics on arterial wall.

Published
2015
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15. Influence of Apolipoproteins on the Association Between Lipids and Insulin Sensitivity: A cross-sectional analysis of the RISC Study

Author

Baldi, S., Bonnet, F., Laville, M., Morgantini, C., Monti, L., Hojlund, K., Ferrannini, E., Natali, A., Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, Filippo, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Gaffney, P, Boran, G, Baldi, S, Balkau, B, Mhamdi, L, Mari, A, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Tura, A, Hills, Sa, Dekker, Jm, and Walker, M.

Published
2013

16. From metabolic normality to cardiometabolic risk factors in subjects with obesity

Author

Elisabetta Bobbioni Harsch, Zoltan, Pataky, Vincent, Makoundou, Martine, Laville, Emmanuel, Disse, Christian, Anderwald, Thomas, Konrad, Alain, Golay, Heine, Rj, Dekker, J, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Pataky, Z, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Subjects
Adult, Male, medicine.medical_specialty, Obesity, cardiometabolic risk factors, Carotid Artery, Common, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Blood Pressure, Overweight, Carotid Intima-Media Thickness, Body Mass Index, Impaired glucose tolerance, Young Adult, Endocrinology, Insulin resistance, Reference Values, Risk Factors, Internal medicine, Glucose Intolerance, medicine, Humans, Obesity, ddc:613, Nutrition and Dietetics, business.industry, Body Weight, Fasting, Middle Aged, medicine.disease, Impaired fasting glucose, Blood pressure, Cardiovascular Diseases, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, Insulin Resistance, business, Lipoproteins, HDL, Body mass index, Weight gain
Abstract

The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high-density lipoprotein (HDL)-cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study were analyzed. We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above-mentioned cardiometabolic risk factors. At 3 years, these parameters were re-evaluated. Intima-media thickness (IMT) of the common carotid artery (CCA) was echographically measured. At follow-up, the incidence of one or more cardiometabolic risk factors was 57.2% in ow/ob vs. 31.7% in nbw (P < 0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity, and fasting insulinemia, BMI remained significantly linked to the development of one or more cardiometabolic risk factors (P = 0.02). An increased BMI at follow-up was significantly associated with the development of cardiometabolic alterations, in both nbw and ow/ob groups (P = 0.04). Ow/ob subjects who, at 3 years follow-up, remained metabolically normal, showed a less favourable cardiometabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima-media of the common carotid at follow-up was thicker than in nbw (P = 0.03 for males, P = 0.04 for females). In conclusion, metabolically normal obese subjects show a higher incidence of cardiometabolic risk factors, in a short follow-up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.

Published
2012

17. Fatty liver index, gamma-glutamyltransferase, and early carotid plaques

Author

Kozakova, M, Palombo, C, Eng, Mp, Dekker, J, Flyvbjerg, A, Mitrakou, A, Gastaldelli, A, Ferrannini, E, Heine, Rj, Dekker, Jm, de Rooij, S, Nijpels, G, Boorsma, W, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni Harsch, E, Barthassat, V, Makoundou, V, Lehmann, T, Merminod, T, Petrie, J, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere AB, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Me, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Beck Nielsen, H, Kok, A, Patel, S, Ciociaro, D, Guillanneuf, Mt, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes

Subjects
Carotid Artery Diseases, Male, SMOOTH-MUSCLE-CELLS, Comorbidity, INTIMA-MEDIA THICKNESS, Severity of Illness Index, ADIPONECTIN, AMERICAN-HEART-ASSOCIATION, Prevalence, Gamma-glutamyltransferase, Ultrasonography, RISK, biology, INSULIN SENSITIVITY, Fatty liver, gamma-Glutamyltransferase, Middle Aged, Prognosis, Plaque, Atherosclerotic, Survival Rate, CARDIOVASCULAR-DISEASE, Hypertension, Female, Waist Circumference, Adult, medicine.medical_specialty, HEPATIC STEATOSIS, PLASMA-PROTEIN, ATHEROSCLEROSIS, Risk Assessment, Insulin resistance, Age Distribution, Internal medicine, Diabetes mellitus, medicine, Humans, Sex Distribution, Proportional Hazards Models, Hepatology, Adiponectin, business.industry, medicine.disease, Fatty Liver, Endocrinology, Cross-Sectional Studies, Logistic Models, Intima-media thickness, Multivariate Analysis, biology.protein, Metabolic syndrome, Insulin Resistance, business, Dyslipidemia
Abstract

An association between fatty liver and carotid atherosclerosis has been established; however, it is not clear whether this relationship is a consequence of shared conventional risk factors or whether it is determined by specific circulating factors originating from liver or adipose tissue. To identify the factors possibly linking fatty liver and atherosclerosis, we assessed, in 1,012 subjects free of confounding diseases (e.g., hypertension, diabetes, cardiovascular diseases, and dyslipidemia) and metabolic syndrome, the relationship between the presence of early plaques at carotid bifurcation and fatty liver index (FLI; a validated surrogate marker of fatty liver), as well as the associations between carotid plaque presence and established atherosclerotic risk factors, family history of cardiovascular disease (FH-CVD) or diabetes, insulin sensitivity, serum liver enzymes, adipokines, fatty free acids, and high-sensitivity C-reactive protein (hsCRP). A total of 55 of 1,012 subjects (5.4%) had small plaque at carotid bifurcation. Subjects with plaque were older and had higher prevalence of FLI ≥60 and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05). In a logistic regression model, adjusted for sex, liver transaminase, and alcohol consumption, the independent predictors of plaque presence were age (P < 0.0005), FLI ≥60 (P < 0.0005), and current smoking (P < 0.05). When FLI in the model was replaced by variables used in its equation (e.g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05). Conclusions: Our cross-sectional study suggests that subjects with FLI ≥60 are at higher risk of atherosclerotic lesions, independently of established risk factors, and that serum GGT may represent a link between fatty liver and the development of early atherosclerosis. (HEPATOLOGY 2012)

Published
2012
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18. Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

Author

Handberg, A, Højlund, K, Gastaldelli, A, Flyvbjerg, A, Dekker, Jm, Petrie, J, Piatti, P, Beck Nielsen, H, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, Eh, Barthassat, V, Makoundou, V, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, de la Perriere AB, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Dirocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Ciociaro, D, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, and Mota, L.

Subjects
Adult, CD36 Antigens, Male, Enzyme-Linked Immunosorbent Assay, Middle Aged, Atherosclerosis, Body Mass Index, Cohort Studies, Europe, Fatty Liver, Cross-Sectional Studies, Predictive Value of Tests, Diabetes Mellitus, Humans, Female, Prospective Studies, Insulin Resistance, Algorithms, Biomarkers
Abstract

Insulin resistance is associated with increased CD36 expression in a number of tissues. Moreover, excess macrophage CD36 may initiate atherosclerotic lesions. The aim of this study was to determine whether plasma soluble CD36 (sCD36) was associated with insulin resistance, fatty liver and carotid atherosclerosis in nondiabetic subjects.In 1296 healthy subjects without diabetes or hypertension recruited from 19 centres in 14 European countries (RISC study), we determined the levels of sCD36, adiponectin, lipids and liver enzymes, insulin sensitivity (M/I) by euglycaemic-hyperinsulinaemic clamp, carotid atherosclerosis as intima-media thickness (IMT) and two estimates of fatty liver, the fatty liver index (FLI) and liver fat percentage (LF%).IMT, FLI, LF%, presence of the metabolic syndrome, impaired glucose regulation, insulin and triglycerides increased across sCD36 quartiles (Q2-Q4), whereas adiponectin and M/I decreased (P ≤ 0.01). sCD36 was lower in women than in men (P = 0.045). Log sCD36 showed a bimodal distribution, and amongst subjects with sCD36 within the log-normal distribution (log-normal population, n = 1029), sCD36 was increased in subjects with impaired glucose regulation (P = 0.045), metabolic syndrome (P = 0.006) or increased likelihood of fatty liver (P0.001). sCD36 correlated significantly with insulin, triglycerides, M/I and FLI (P0.05) after adjustment for study centre, gender, age, glucose tolerance status, smoking habits and alcohol consumption. In the log-normal population, these relationships were stronger than in the total study population and, additionally, sCD36 was significantly associated with LF% and IMT (P0.05).In this cross-sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter-relationship between atherosclerosis, fatty liver and insulin resistance.

Published
2011

19. Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

Author

Ferrannini, E, Natali, A, Muscelli, E, Nilsson, Pm, Golay, A, Laakso, M, Beck Nielsen, H, Mari, A, Dekker, Jm, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Tura, A, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, and Balkau, B.

Published
2011

20. A novel surrogate index for hepatic insulin resistance

Author

Vangipurapu, J, Stančáková, A, Kuulasmaa, T, Paananen, J, Kuusisto, J, EGIR RISC Study Group, Ferrannini, E, Laakso, M, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perrier, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Pacini, G, Cavaggion, C, Hills, Sa, and Mota

Published
2011

21. Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study

Author

Rebelos, E, Muscelli, E, Natali, A, Balkau, B, Mingrone, G, Piatti, P, Konrad, T, Mari, A, Ferrannini, E, Dekker, Jm, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Tura, A, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Pinnola, S, Kozakova, M, Casolaro, A, Astiarraga, Bd, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, and Balkau

Published
2011

22. Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population

Author

Kozàkovà, M, Palombo, C, Morizzo, C, Nolan, Jj, Konrad, T, Balkau, B, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sanchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhausl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2010

23. Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance

Author

Natali, A., Muscelli, E., Mari, A., Balkau, B., Walker, M., Tura, A., Anderwald, C., Golay, A., Ferrannini, E., Dekker, J. M., de Rooij, S., Nijpels, G., Boorsma, W., Mitrakou, A., Tournis, S., Kyriakopoulou, K., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Konrad, T., Böhles, H., Fuellert, S., Baer, F., Zuchhold, H., Bobbioni, E. H., Barthassat, V., Makoundou, V., Lehmann, T. N., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Laville, M., Bonnet, F., Brac de la Perriere, A., Louche Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sánchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Beck Nielsen, H., Staehr, P., Hojlund, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F., Saturni, A., Pinnola, S., Kozakova, M., Casolaro, A., Astiarraga, B. D., Mingrone, G., Guidone, C., Favuzzi, A., Di Rocco, P., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhäusl, W., Roden, M., Gaffney, P., Boran, G., Mhamdi, L., Landucci, L., Hills, S., Mota, L., Pacini, G., and Cavaggion, C.

Published
2010

24. Impact of family history on relations between insulin resistance, LDL cholesterol and carotid IMT in healthy adults

Author

Anderwald, C, Stadler, M, Golay, A, Krebs, M, Petrie, J, Luger, A, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Bönles, H, Franke, S, Baer, F, Zuchhold, H, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm Kuopio, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Bischof, M, Promintzer, M, Mandl, M, Hofer, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2010

25. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E., Kozakova, M., Flyvbjerg, A., Kyriakopoulou, K., Astiarraga, B. D., Glintborg, D., Konrad, T., Favuzzi, A., Petrie, J., Heine, R. J., Dekker, J., De Rooij, S., Nijpels, G., Boorsma, W., Mitrakou, A., Tournis, S., Thomakos, P., Lalic, N., Lalic, K., Jotic, A., Lukic, L., Civcic, M., Nolan, J., Yeow, T. P., Murphy, M., Delong, C., Neary, G., Colgan, M. P., Hatunic, M., Bohles, H., Fuellert, S., Baer, F., Zuchhold, H., Golay, A., Harsch Bobbioni, E., Barthassat, V., Makoundou, V., Lehmann, T. N. O., Merminod, T., Petrie, J. R., Perry, C., Neary, F., Macdougall, C., Shields, K., Malcolm, L., Laakso, M., Salmenniemi, U., Aura, A., Raisanen, R., Ruotsalainen, U., Sistonen, T., Laitinen, M., Saloranta, H., Coppack, S. W., Mcintosh, N., Ross, J., Pettersson, L., Khadobaksh, P., Laville, M., Bonnet, F., Brac De La Perriere, A., Louche-Pelissier, C., Maitrepierre, C., Peyrat, J., Beltran, S., Serusclat, A., Gabriel, R., Sanchez, E. M., Carraro, R., Friera, A., Novella, B., Nilsson, P., Persson, M., Ostling, G., Melander, O., Burri, P., Piatti, P. M., Monti, L. D., Setola, E., Galluccio, E., Minicucci, F., Colleluori, A., Walker, M., Ibrahim, I. M., Jayapaul, M., Carman, D., Ryan, C., Short, K., Mcgrady, Y., Richardson, D., Beck-Nielsen, H., Staehr, P., Hojlund, K., Vestergaard, V., Olsen, C., Hansen, L., Bolli, G. B., Porcellati, F., Fanelli, C., Lucidi, P., Calcinaro, F., Saturni, A., Ferrannini, E., Natali, A., Pinnola, S., Mingrone, G., Guidone, C., Di Rocco, P., Anderwald, C., Bischof, M., Promintzer, M., Krebs, M., Mandl, M., Hofer, A., Luger, A., Waldhausl, W., Roden, M., Balkau, B., Dekker, J. M., Mari, A., Gaffney, P., Boran, G., Kok, A., Patel, S., Gastaldelli, A., Ciociaro, D., Guillanneuf, M. T., Mhamdi, L., Pacini, G., Cavaggion, C., Hills, S. A., Landucci, L., and Mota, L.

Subjects
Blood Glucose, medicine.medical_specialty, Carotid Artery, Common, medicine.medical_treatment, Blood Pressure, Insulin resistance, Risk Factors, medicine.artery, Internal medicine, Insulin Secretion, Internal Medicine, Medicine, Humans, Insulin, Common carotid artery, cardiovascular diseases, Ultrasonography, Adiponectin, Cardiovascular Diseases, Cross-Sectional Studies, Female, Insulin Resistance, Menopause, Middle Aged, Tunica Intima, Tunica Media, business.industry, medicine.disease, Common, Endocrinology, Blood pressure, Intima-media thickness, cardiovascular system, Carotid Artery, business, Body mass index
Abstract

BACKGROUND The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. METHODS In 74 menopausal women (mean age = 51 +/- 3 years, mean duration of menopause = 2.9 +/- 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound images. Insulin sensitivity and secretion were assessed using the euglycemic hyperinsulinemic clamp technique and oral glucose tolerance test (OGTT). Insulin secretion was reconstructed by mathematical modeling. RESULTS CCA diameter (5.55 +/- 0.46 vs. 5.21 +/- 0.51 mm, P less than 0.001), CCA IMT (608 +/- 78 vs. 576 +/- 74 mu m, P less than 0.01) and systolic blood pressure (BP) 0 17 +/- 12 vs. 113 +/- 11 mm Hg, P less than 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid segments did not differ between the groups. By multivariate models, independent predictors of CCA diameter were menopause and body weight (cumulative R-2 = 0.37) and independent correlates of CCA IMT were luminal diameter, systolic BP and low-density lipoprotein (LDL) cholesterol (cumulative R-2 = 0.48). Fasting insulin, insulin secretion, and sensitivity and plasma adiponectin were similar in the two groups and were not related to carotid IMT. CONCLUSIONS Early menopause is associated with CCA remodeling, characterized by a proportional increase in luminal diameter and wall thickness, independent of atherosclerotic risk factors and metabolic variables.

Published
2009
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26. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: The RISC study

Author

De Rooij, S.R. Dekker, J.M. Kozakova, M. Mitrakou, A. Melander, O. Gabriel, R. Guidone, C. Højlund, K. Murphy, M.S. Nijpels, G. Dekker, J. De Rooij, S. Nijpels, G. Boorsma, W. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Harsch Bobbioni, E. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Petrie, J.R. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Laville, M. Bonnet, F. Brac De La Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, M.E. Carraro, R. Friera, A. Perez, S. Nilsson, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Beck-Nielsen, H. Staehr, P. Hojlund, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferrannini, E. Natali, A. Muscelli, E. Pinnola, S. Kozakova, M. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Balkau, B. Coppack, S.W. Dekker, J.M. Ferrannini, E. Mari, A. Walker, M. Gaffney, P. Nolan, J. Boran, G. Olsen, C. Hansen, L. Beck-Nielsen, H. Kok, A. Dekker, J. Patel, S. Walker, M. Gastaldelli, A. Ciociaro, D. Kozakova, M. Guillanneuf, M.T. Balkau, B. Mhamdi, L. Balkau, B. Balkau, B. Mari, A. Mhamdi, L. Landucci, L. Hills, S. Mota, L. Mari, A. Pacini, G. Cavaggion, C. Hills, S.A. Landucci, L. Mota, L.

Abstract

Objective: Fasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30-60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis. Results: Fasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8-10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6-9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3-4.7, adjusted for fasting insulin) in men and 1.6 (0.8-3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women. Conclusions: Fasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity. © 2009 European Society of Endocrinology.

Published
2009

27. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E. Kozàkovà, M. Flyvbjerg, A. Kyriakopoulou, K. Astiarraga, B.D. Glintborg, D. Konrad, T. Favuzzi, A. Petrie, J.R. Heine, R.J. Dekker, J. De Rooij, S. Nijpels, G. Boorsma, W. Mitrakou, A. Tournis, S. Kyriakopoulou, K. Thomakos, P. Lalic, N. Lalic, K. Jotic, A. Lukic, L. Civcic, M. Nolan, J. Yeow, T.P. Murphy, M. DeLong, C. Neary, G. Colgan, M.P. Hatunic, M. Konrad, T. Böhles, H. Fuellert, S. Baer, F. Zuchhold, H. Golay, A. Harsch Bobbioni, E. Barthassat, V. Makoundou, V. Lehmann, T.N.O. Merminod, T. Perry, C. Neary, F. MacDougall, C. Shields, K. Malcolm, L. Laakso, M. Salmenniemi, U. Aura, A. Raisanen, R. Ruotsalainen, U. Sistonen, T. Laitinen, M. Saloranta, H. Coppack, S.W. McIntosh, N. Ross, J. Pettersson, L. Khadobaksh, P. Laville, M. Bonnet, F. Brac De La Perriere, A. Louche-Pelissier, C. Maitrepierre, C. Peyrat, J. Beltran, S. Serusclat, A. Gabriel, R. Sánchez, E.M. Carraro, R. Friera, A. Novella, B. Nilsson, P. Persson, M. Östling, G. Melander, O. Burri, P. Piatti, P.M. Monti, L.D. Setola, E. Galluccio, E. Minicucci, F. Colleluori, A. Walker, M. Ibrahim, I.M. Jayapaul, M. Carman, D. Ryan, C. Short, K. McGrady, Y. Richardson, D. Beck-Nielsen, H. Staehr, P. Hojlund, K. Vestergaard, V. Olsen, C. Hansen, L. Bolli, G.B. Porcellati, F. Fanelli, C. Lucidi, P. Calcinaro, F. Saturni, A. Ferrannini, E. Natali, A. Muscelli, E. Pinnola, S. Kozakova, M. Mingrone, G. Guidone, C. Favuzzi, A. Di Rocco, P. Anderwald, C. Bischof, M. Promintzer, M. Krebs, M. Mandl, M. Hofer, A. Luger, A. Waldhäusl, W. Roden, M. Balkau, B. Coppack, S.W. Dekker, J.M. Ferrannini, E. Mari, A. Walker, M. Gaffney, P. Nolan, J. Boran, G. Olsen, C. Hansen, L. Beck-Nielsen, H. Kok, A. Dekker, J. Patel, S. Walker, M. Gastaldelli, A. Ciociaro, D. Kozakova, M. Guillanneuf, M.T. Balkau, B. Mhamdi, L. Mari, A. Pacini, G. Cavaggion, C. Hills, S.A. Landucci, L. Mota, L.

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Background: The mechanisms by which menopause may influence the systemic subclinical atherosclerosis are unexplained. The aim of this cross-sectional study was to evaluate the associations between early menopause, established cardiovascular (c-v) risk factors, metabolic parameters (insulin secretion and sensitivity, plasma adiponectin), and carotid intima-media thickness (IMT) in healthy women. Methods: In 74 menopausal women (mean age = 51 ± 3 years, mean duration of menopause = 2.9 ± 1.2 years) and in 74 nonmenopausal women comparable for age and body mass index (BMI), common carotid artery (CCA) luminal diameter, and IMT in different carotid segments were measured in digitized ultrasound images. Insulin sensitivity and secretion were assessed using the euglycemic hyperinsulinemic clamp technique and oral glucose tolerance test (OGTT). Insulin secretion was reconstructed by mathematical modeling. Results: CCA diameter (5.55 ± 0.46 vs. 5.21± 0.51 mm, P < 0.001), CCA IMT (608 ± 78 vs. 576 ± 74 νm, P < 0.01) and systolic blood pressure (BP) (117 ± 12 vs. 113 ± 11 mm Hg, P < 0.05) were higher in menopausal women, whereas CCA IMT/diameter ratio and IMT in other carotid segments did not differ between the groups. By multivariate models, independent predictors of CCA diameter were menopause and body weight (cumulative R2= 0.37) and independent correlates of CCA IMT were luminal diameter, systolic BP and low-density lipoprotein (LDL) cholesterol (cumulative R2= 0.48). Fasting insulin, insulin secretion, and sensitivity and plasma adiponectin were similar in the two groups and were not related to carotid IMT. Conclusions: Early menopause is associated with CCA remodeling, characterized by a proportional increase in luminal diameter and wall thickness, independent of atherosclerotic risk factors and metabolic variables. © 2009 American Journal of Hypertension, Ltd.

Published
2009

28. The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women

Author

Muscelli, E, Kozàkovà, M, Flyvbjerg, A, Kyriakopoulou, K, Astiarraga, Bd, Glintborg, D, Konrad, T, Favuzzi, A, Petrie, J, Heine, Rj, Dekker, J, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2009

29. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population

Author

Gastaldelli, A, Kozakova, M, Højlund, K, Flyvbjerg, A, Favuzzi, A, Mitrakou, A, Balkau, B, Heine, Rj, Dekker, J, Nijpels, G, Boorsma, W, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Bohles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, and Mota, L.

Published
2009

30. Body composition and common carotid artery remodeling in a healthy population

Author

Kozakova, M, Palombo, C, Paterni, M, Anderwald, Ch, Konrad, T, Colgan, Mp, Flyvbjerg, A, Dekker, J, Heine, Rj, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Hatunic, M, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Bobbioni, Eh, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, and Roden, M.

Published
2008

31. Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects

Author

Bonnet, F, Patel, S, Laville, M, Balkau, B, Favuzzi, A, Monti, Ld, Lalic, N, Walker, M, Heine, Rj, Dekker, J, DE ROOIJ, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, HARSCH BOBBIONI, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Dundee, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Rennes, F, BRAC DE LA PERRIERE, A, LOUCHE PELISSIER, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Ostling, G, Melander, O, Burri, P, Piatti, Pm, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, BECK NIELSEN, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, F, Fanelli, Carmine Giuseppe, Lucidi, P, Calcinaro, Filippo, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Mingrone, G, Guidone, C, DI ROCCO, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Dekker, Jm, Mari, A, Gaffney, P, Boran, G, Kok, A, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, and Hills, Sa

Published
2008

35. Pharmacological treatment of the pathogenetic defects in type 2 diabetes: the randomized multicenter South Danish Diabetes Study.

Author

Gram J, Henriksen JE, Grodum E, Juhl H, Hansen TB, Christiansen C, Yderstræde K, Gjessing H, Hansen HM, Vestergaard V, Hangaard J, Beck-Nielsen H, Gram, Jeppe, Henriksen, Jan Erik, Grodum, Ellen, Juhl, Henning, Hansen, Tony Bill, Christiansen, Christian, Yderstræde, Knud, and Gjessing, Hans

Abstract

Objective: To determine the effect of treatment with insulin aspart compared with NPH insulin, together with metformin/placebo and rosiglitazone/placebo. The hypothesis was that combined correction of major pathogenetic defects in type 2 diabetes would result in optimal glycemic control.Research Design and Methods: This study was a 2-year investigator-driven randomized partly placebo-controlled multicenter trial in 371 patients with type 2 diabetes on at least oral antiglycemic treatment. Patients were assigned to one of eight treatment groups in a factorial design with insulin aspart at mealtimes versus NPH insulin once daily at bedtime, metformin twice daily versus placebo, and rosiglitazone twice daily versus placebo. The main outcome measurement was change in A1C.Results: A1C decreased more in patients treated with insulin aspart compared with NPH (-0.41 ± 0.10%, P < 0.001). Metformin decreased A1C compared with placebo (-0.60 ± 0.10%, P < 0.001), as did rosiglitazone (-0.55 ± 0.10%, P < 0.001). Triple therapy (rosiglitazone, metformin, and any insulin) resulted in a greater reduction in A1C than rosiglitazone plus insulin (-0.50 ± 0.14%, P < 0.001) and metformin plus insulin (-0.45 ± 0.14%, P < 0.001). Aspart was associated with a higher increase in body weight (1.6 ± 0.6 kg, P < 0.01) and higher incidence of mild daytime hypoglycemia (4.9 ± 7.5 vs. 1.7 ± 5.4 number/person/year, P < 0.001) compared with NPH.Conclusions: Insulin treatment of postprandial hyperglycemia results in lower A1C than treatment of fasting hyperglycemia, at the expense of higher body weight and hypoglycemic episodes. However, insulin therapy has to be combined with treatment of both peripheral and liver insulin resistance to normalize blood glucose, and in this case, the insulin regimen is less important. [ABSTRACT FROM AUTHOR]

Published
2011
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40. Accurate Post-Calibration Predictions for Noninvasive Glucose Measurements in People Using Confocal Raman Spectroscopy.

Author

Pors A, Rasmussen KG, Inglev R, Jendrike N, Philipps A, Ranjan AG, Vestergaard V, Henriksen JE, Nørgaard K, Freckmann G, Hepp KD, Gerstenberg MC, and Weber A

Subjects
Humans, Spectrum Analysis, Raman methods, Blood Glucose, Blood Glucose Self-Monitoring, Calibration, Diabetes Mellitus, Type 2 diagnosis
Abstract

In diabetes prevention and care, invasiveness of glucose measurement impedes efficient therapy and hampers the identification of people at risk. Lack of calibration stability in non-invasive technology has confined the field to short-term proof of principle. Addressing this challenge, we demonstrate the first practical use of a Raman-based and portable non-invasive glucose monitoring device used for at least 15 days following calibration. In a home-based clinical study involving 160 subjects with diabetes, the largest of its kind to our knowledge, we find that the measurement accuracy is insensitive to age, sex, and skin color. A subset of subjects with type 2 diabetes highlights promising real-life results with 99.8% of measurements within A + B zones in the consensus error grid and a mean absolute relative difference of 14.3%. By overcoming the problem of calibration stability, we remove the lingering uncertainty about the practical use of non-invasive glucose monitoring, boding a new, non-invasive era in diabetes monitoring.

Published
2023
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41. Do Knee Osteoarthritis Patterns Affect Patient-Reported Outcomes in Total Knee Arthroplasty? Results From an International Multicenter Prospective Study With 3-Year Follow-Up.

Author

Vestergaard V, Colon Iban YE, Kappel A, Melnic CM, Bedair H, Huddleston JI 3rd, Bragdon CR, Malchau H, and Troelsen A

Subjects
Activities of Daily Living, Follow-Up Studies, Humans, Knee Joint diagnostic imaging, Knee Joint surgery, Patient Reported Outcome Measures, Prospective Studies, Quality of Life, Treatment Outcome, Arthroplasty, Replacement, Knee adverse effects, Osteoarthritis, Knee surgery
Abstract

Background: The aim of this multicenter study is to answer (1) Does patellofemoral osteoarthritis (OA) affect preoperative Knee Injury and Osteoarthritis Outcome Score (KOOS) scores in total knee arthroplasty (TKA)? and (2) Do different OA patterns affect preoperative and postoperative KOOS scores in TKA?, Methods: This international, multicenter prospective study examined 384 TKA patients. Compartmental OA was divided into (1) medial, (2) medial + patellofemoral, (3) lateral, (4) lateral + patellofemoral, (5) medial + lateral (bicompartmental), and (6) medial + lateral + patellofemoral (tricompartmental), based on preoperative anterior-posterior and lateral ± skyline radiographs with Kellgren-Lawrence grade III-IV and joint space width <2.5 mm. KOOS was collected preoperatively, 1 year postoperatively, and 3 years postoperatively. Higher KOOS score represented better clinical state, for example, higher KOOS Pain score indicated less pain., Results: Patellofemoral OA had no effect on preoperative KOOS scores (P > .15). Compared to medial ± patellofemoral OA patients, bicompartmental/tricompartmental OA patients had less preoperative pain (KOOS Pain 7.4, P = .03) and higher daily function (KOOS-ADL [Activities of Daily Living] 7.1, P = .05), and higher 1-year postoperative daily function (KOOS-ADL 9.2, P = .03) and sports activity (KOOS Sports & Recreation Function 15.0, P = .04), while lateral ± patellofemoral OA patients had more symptoms (KOOS-Symptoms 7.0, P < .01), more pain (KOOS-Pain 7.5, P = .01), lower daily function (KOOS-ADL 9.3, P < .01), and lower quality of life (KOOS-QOL 9.0, P = .04), at 3 years postoperatively., Conclusion: Patellofemoral OA does not affect medial ± lateral OA patients' preoperative KOOS scores, challenging the importance of patellofemoral OA in TKA. Lateral ± patellofemoral OA patients have lower postoperative KOOS scores than medial/more progressed compartmental OA patients, indicating that patients with less common OA patterns present with unique surgical challenges. Further development of indications for and correct timing of TKA surgery in different patient subgroups is needed., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2021
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42. Patient-reported outcomes of 7133 distal femoral, patellar, and proximal tibial fracture patients: A national cross-sectional study with one-, three-, and five-year follow-up.

Author

Vestergaard V, Schrøder HM, Hare KB, Toquer P, Troelsen A, and Pedersen AB

Subjects
Adult, Age Factors, Arthroplasty, Replacement, Knee adverse effects, Comorbidity, Cross-Sectional Studies, External Fixators adverse effects, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patella injuries, Risk Factors, Visual Analog Scale, Femoral Fractures surgery, Fractures, Bone surgery, Patella surgery, Patient Reported Outcome Measures, Tibial Fractures surgery
Abstract

Background: Few studies have described patient-reported outcome measures (PROMs) in knee fracture patients. We reported knee-specific and generic median PROM scores after knee fracture and identified risk factors for poor outcome defined by low median PROM scores., Methods: In a Danish cross-sectional study of 7133 distal femoral, patellar, and proximal tibial fracture patients during 2011-2017, OKS, FJS-12, EQ5D-5L Index, and EQ5D-5L Visual Analogue Scale (VAS), were collected electronically (response rate 53%; median age 60; 63% female). Poor outcome was defined as score lower than median PROM score. Poor outcome risk factors were estimated as odds ratios from binary logistic regression models., Results: At 0 to one year after knee fracture, median PROM scores were 31 (OKS), 27 (FJS-12), 0.50 (EQ5D-5L Index), and 74 (EQ5D-5L VAS). At >5 years after knee fracture, median OKS score was 40, median FJS-12 score was 54, median EQ5D-5L Index was 0.76, and median EQ5D-5L VAS score was 80. Age > 40 years had higher odds for poor OKS and FJS-12 scores at short- and long-term follow-up after knee fracture. Comorbidity burden, distal femoral fracture, and treatment with external fixation and knee arthroplasty were risk factors for poor outcome at long-term follow-up, for all four PROMs., Conclusions: Although knee fracture patients have relatively high knee function and quality of life, their ability to forget about the knee joint after knee fracture is compromised. We identified several important risk factors for poor outcome measured by PROMs at different follow-up periods following knee fracture, which will help direct future quality-improvement initiatives., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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43. Knee Fracture Increases TKA Risk After Initial Fracture Treatment and Throughout Life.

Author

Vestergaard V, Becic Pedersen A, Borbjerg Hare K, Morville Schrøder H, and Troelsen A

Subjects
Adult, Aged, Case-Control Studies, Denmark, Female, Fracture Fixation adverse effects, Humans, Knee Injuries complications, Male, Middle Aged, Open Fracture Reduction adverse effects, Open Fracture Reduction statistics & numerical data, Osteoarthritis, Knee etiology, Postoperative Complications etiology, Prognosis, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Arthroplasty, Replacement, Knee statistics & numerical data, Fracture Fixation statistics & numerical data, Knee Injuries surgery, Osteoarthritis, Knee surgery, Postoperative Complications surgery
Abstract

Background: Knee fractures may lead to post-traumatic knee osteoarthritis and subsequent TKA in some patients. However, absolute risk estimates and risk factors for TKA in patients with knee fractures compared with those of the general population remain largely unknown. Such knowledge would help establish the treatment burden and direct patient counseling after a knee fracture is sustained., Questions/purposes: (1) What is the short-term risk of TKA after knee fracture? (2) What is the long-term risk of TKA after knee fracture? (3) What are the risk factors for TKA in patients with knee fractures?, Methods: A nationwide 20-year, matched-case comparison cohort study of prospectively collected data from the Danish National Patient Registry included all patients at least 15 years old with International Classification of Diseases, 10th revision codes DS724, DS820, or DS821 (knee fractures) on the date their knee fracture was registered. Each patient with a knee fracture was matched (by sex and age) to five people without knee fractures from the general Danish population on the date the knee fracture patient's knee fracture was registered (population controls). Patients with knee fractures and people in the population control group were followed from the date the knee fracture patient's knee fracture was registered to the date of TKA, amputation, knee fusion, emigration, death, or end of follow-up in April 2018. TKA risks for patients with knee fractures versus those for population controls and TKA risk factors in patients with knee fractures were estimated using hazard ratios (HRs) with 95% CIs. A total of 48,791 patients with knee fractures (median age 58 years [interquartile range 41-73]; 58% were female) were matched to 263,593 people in the population control group., Results: The HR for TKA in patients with knee fractures compared with population controls was 3.74 (95% CI 3.44 to 4.07; p < 0.01) in the first 3 years after knee fracture. Among knee fracture patients, the risk of undergoing TKA was 2% (967 of 48,791) compared with 0.5% (1280 of 263,593) of people in the population control group. After the first 3 years, the HR was 1.59 (95% CI 1.46 to 1.71) and the number of patients with knee fractures with TKA events divided by the number at risk was 2% (849 of 36,272), compared with 1% (2395 of 180,418) of population controls. During the 20-year study period, 4% of patients with knee fractures underwent TKA compared with 1% of population controls. Risk factors for TKA in patients with knee fractures were: primary knee osteoarthritis (OA) versus no primary knee OA (HR 9.57 [95% CI 5.39 to 16.98]), surgical treatment with external fixation versus open reduction and internal fixation and reduction only (HR 1.92 [95 % CI 1.01 to 3.66]), proximal tibia fracture versus patellar fracture (HR 1.75 [95 % CI 1.30 to 2.36]), and distal femur fracture versus patellar fracture (HR 1.68 [95 % CI 1.08 to 2.64]). Surgical treatment of knee fractures was also a risk factor for TKA. The HRs for TKA in patients with knee fractures who were surgically treated versus those who were treated non-surgically were 2.05 (95% CI 1.83 to 2.30) in the first 5 years after knee fracture and 1.19 (95% CI 1.01 to 1.41) after 5 years., Conclusions: Patients with knee fractures have a 3.7 times greater risk of TKA in the first 3 years after knee fracture, and the risk remains 1.6 times greater after 3 years and throughout their lifetimes. Primary knee OA, surgical treatment of knee fractures, external fixation, proximal tibia fractures, and distal femur fractures are TKA risk factors. These risk estimates and risk factors highlight the treatment burden of knee fractures, building a foundation for future studies to further counsel patients on their risk of undergoing TKA based on patient-, fracture-, and treatment-specific factors., Level of Evidence: Level III, prognostic study.

Published
2020
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44. The AAHKS Clinical Research Award: No Evidence for Superior Patient-Reported Outcome Scores After Total Hip Arthroplasty With the Direct Anterior Approach at 1.5 Months Postoperatively, and Through a 5-Year Follow-Up.

Author

Sauder N, Vestergaard V, Siddiqui S, Galea VP, Bragdon CR, Malchau H, Elsharkawy KA, Huddleston JI 3rd, and Emerson RH

Subjects
Follow-Up Studies, Humans, Patient Reported Outcome Measures, Treatment Outcome, Arthroplasty, Replacement, Hip adverse effects, Awards and Prizes
Abstract

Background: The direct anterior approach to total hip arthroplasty (THA) may result in superior early postoperative patient-reported outcome measures (PROMs). This study compared PROMs between THA patients treated with the direct anterior or posterolateral approach between 1.5 months and 5 years, using literature-derived patient acceptable symptom state (PASS) and minimal clinically important improvement (MCII) thresholds., Methods: A propensity score match of 93 direct anterior patients to 93 posterolateral patients from a multicenter US collaboration (6 centers, 398 patients) was performed. The Harris Hip Score (HHS), the Short-Form 36, and a Numerical Rating Scale for Pain were collected preoperatively, postoperatively (mean days: 47), and at 1, 3, and 5 years. The proportion of patients reaching the HHS PASS, Pain MCII, and Function MCII in the direct anterior and posterolateral groups was compared using binary logistic regressions, controlling for age, gender, body mass index, and Charnley score., Results: Direct anterior patients were less likely to reach the HHS PASS at the postoperative visit (P = .015; odds ratio = 0.454), but not at later visits (P > .082). Direct anterior patients had no difference from posterolateral patients in their tendency to reach the Pain MCII postoperatively or at 1 year (P > .090). The direct anterior patients were less likely to reach the Function MCII at the postoperative visit (P = .011; odds ratio = 0.422), but not at 1 year (P = .958)., Conclusion: No evidence was found of superior early postoperative PROM scores in THA patients treated with the direct anterior approach. No PROM differences were found at or beyond 1 year, indicating that patients reach similar final symptom states, regardless of surgical approach., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2020
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45. 20-year trends of distal femoral, patellar, and proximal tibial fractures: a Danish nationwide cohort study of 60,823 patients.

Author

Vestergaard V, Pedersen AB, Tengberg PT, Troelsen A, and Schrøder HM

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Arthroplasty, Replacement, Knee, Bone Plates, Child, Child, Preschool, Cohort Studies, Denmark epidemiology, Female, Femoral Fractures surgery, Fracture Fixation, Internal, Fractures, Multiple surgery, Humans, Incidence, Infant, Infant, Newborn, Knee Injuries surgery, Male, Middle Aged, Open Fracture Reduction, Patella surgery, Population Growth, Tibial Fractures surgery, Young Adult, Femoral Fractures epidemiology, Fractures, Multiple epidemiology, Knee Injuries epidemiology, Patella injuries, Tibial Fractures epidemiology
Abstract

Background and purpose - Knee fracture treatment burden remains unknown, impeding proper use of hospital resources. We examined 20-year trends in incidence rates (IRs) and patient-, fracture-, and treatment-related characteristics of knee fracture patients.Patients and methods - This nationwide cohort study of prospectively collected data including patients with distal femoral, patellar, and proximal tibial fractures from the Danish National Patient Registry during 1998-2017, assesses IRs of knee fractures (per 10 5 inhabitants) as well as patient-, fracture-, and treatment-related characteristics of knee fracture patients.Results - During 1998-2017, 60,823 patients (median age 55; 57% female) sustained 74,106 knee fractures. 74% of the study population had a Charlson Comorbidity Index (CCI) of 0 and 18% a CCI of ≥ 2. 51% were proximal tibial fractures, 31% patellar fractures, and 18% distal femoral fractures. At the time of knee fracture, 20% patients had concomitant near-knee fractures (femur/tibia/fibula shaft/hip/ankle), 13% concomitant fractures (pelvic/spine/thorax/upper extremities), 5% osteoporosis, and 4% primary knee osteoarthritis. Over 1/3 knee fractures were surgically treated and of these 86% were open-reduction internal fixations, 9% external fixations, and 5% knee arthroplasties. The most common surgery type was proximal tibia plating (n = 4,868; 60% female). Knee fracture IR increased 12% to 70, females aged > 51 had the highest knee fracture IR, proximal tibial fracture had the highest knee fracture type IR (32) and surgically treated knee fracture IR increased 35% to 23.Interpretation - Knee fracture IRs, especially of surgically treated knee fractures, are increasing and proximal tibial fracture has the highest knee fracture type IR. Females aged > 51 and patients with comorbidity are associated with knee fracture, proximal tibial fracture, proximal tibial fracture surgery, and posttraumatic knee arthroplasty.

Published
2020
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46. Jessner lymphocytic infiltration - rare in childhood.

Author

Petersen MP, Vestergaard V, and Bygum A

Subjects
Adolescent, Biopsy, Diagnosis, Differential, Facial Dermatoses diagnosis, Facial Dermatoses immunology, Female, Humans, Immunosuppressive Agents therapeutic use, Lupus Erythematosus, Discoid diagnosis, Lymphocytes, Lymphoproliferative Disorders diagnosis, Lymphoproliferative Disorders drug therapy, Rare Diseases, Skin immunology, Tacrolimus therapeutic use, Facial Dermatoses pathology, Lymphoproliferative Disorders pathology, Skin pathology
Abstract

We present a 13-year-old girl with Jessner lymphocytic infiltrate of the skin, who has suffered from the disease since the age of 9 years. It is a rare disease in childhood, and we highlight the clinical features and therapeutic response of tacrolimus.

Published
2017

48. [Dermatomyositis as a paraneoplastic first symptom of ovarian cancer].

Author

Bjørnhart B, Yazdanfard Y, Vestergaard V, and Frifelt JJ

Subjects
Adenocarcinoma diagnosis, Adenocarcinoma secondary, Breast Neoplasms pathology, Dermatomyositis diagnosis, Dermatomyositis pathology, Diagnosis, Differential, Female, Humans, Middle Aged, Ovarian Neoplasms diagnosis, Ovarian Neoplasms secondary, Paraneoplastic Syndromes diagnosis, Paraneoplastic Syndromes pathology, Adenocarcinoma complications, Dermatomyositis complications, Ovarian Neoplasms complications, Paraneoplastic Syndromes complications
Abstract

Dermatomyositis (DM) is a rare disease, which is associated with malignancy in around 20% of cases. DM can precede the diagnosis of ovarian cancer by years. In this case, a 63-year-old woman was diagnosed with DM by biopsy due to diffuse symptoms of oedema in both arms and a spreading violet/dark red rash of both arms and thighs. A large inoperable ovarian tumour was found subsequently. In order to reach an early diagnosis and curatively treat people with cancer, extra focus must be paid on paraneoplastic phenomenons including DM.

Published
2013

49. [Staphylococcal scalded skin syndrome in adults].

Author

Mikkelsen CS, Mikkelsen DB, Jensen TG, and Vestergaard V

Subjects
Aged, Aged, 80 and over, Female, Humans, Staphylococcal Scalded Skin Syndrome drug therapy, Staphylococcal Scalded Skin Syndrome microbiology, Staphylococcus aureus isolation & purification, Staphylococcal Scalded Skin Syndrome pathology
Abstract

We describe a case of adult staphylococcal scalded skin syndrome (SSSS) in a 91-year-old woman. The patient had a Staphylococcus aureus infection in her right ear with redness and yellow secretion. A few days later she developed Nikolsky sign-positive tender enlarged flaccid bullae involving most parts of her body. The bullae ruptured easily and left a erythematous base. The histopathological changes were characteristic for adult SSSS. The patient was well-treated with intravenous dicloxacillin, topical antibiotic and antiseptic treatment. The patient had marked thrombocytosis, but no interest in further examination.

Published
2010

50. [Glucagonoma syndrome without diabetes mellitus].

Author

Mikkelsen CS, Mikkelsen DB, Vestergaard V, Clemmensen O, Nielsen HO, and Bygum A

Subjects
Glucagonoma pathology, Glucagonoma surgery, Humans, Male, Middle Aged, Pancreatic Neoplasms pathology, Pancreatic Neoplasms surgery, Glucagonoma diagnosis, Pancreatic Neoplasms diagnosis
Abstract

A patient developed depression, weight loss, ulcers and a migrating, denuded erythematous skin area. Punch biopsy revealed necrolytic migrating erythema. Computerised tomography and endoscopic ultrasound showed a solid tumour of the pancreas. A blood sample showed an increased level of glucagon without diabetes. Glucagonoma syndrome is characterized by glucagon overproduction, diabetes, depression, deep venous thrombosis and necrolytic migrating erythema. Glucagonoma is frequently diagnosed late which increases the risk of metastases. It is important not to rule out glucagonoma in patients with a relevant clinical picture but without diabetes.

Published
2008

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