Search

Your search keyword '"Vezzani, Bianca"' showing total 24 results
Start Over Author "Vezzani, Bianca"
24 results on '"Vezzani, Bianca"'

1. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment

Author

Missiroli, Sonia, Perrone, Mariasole, Gafà, Roberta, Nicoli, Francesco, Bonora, Massimo, Morciano, Giampaolo, Boncompagni, Caterina, Marchi, Saverio, Lebiedzinska-Arciszewska, Magdalena, Vezzani, Bianca, Lanza, Giovanni, Kricek, Franz, Borghi, Alessandro, Fiorica, Francesco, Ito, Keisuke, Wieckowski, Mariusz R., Di Virgilio, Francesco, Abelli, Luigi, Pinton, Paolo, and Giorgi, Carlotta

Published
2023
Full Text
View/download PDF

2. SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia

Author

Vezzani, Bianca, primary, Perrone, Mariasole, additional, Carinci, Marianna, additional, Palumbo, Laura, additional, Tombolato, Alberto, additional, Tombolato, Denis, additional, Daminato, Claudio, additional, Gentili, Valentina, additional, Rizzo, Roberta, additional, Campo, Gianluca, additional, Morandi, Luca, additional, Papi, Alberto, additional, Spadaro, Savino, additional, Casolari, Paolo, additional, Contoli, Marco, additional, Pinton, Paolo, additional, and Giorgi, Carlotta, additional

Published
2023
Full Text
View/download PDF

3. The role of mitochondria-associated membranes in cellular homeostasis and diseases

Author

Perrone, Mariasole, primary, Caroccia, Natascia, additional, Genovese, Ilaria, additional, Missiroli, Sonia, additional, Modesti, Lorenzo, additional, Pedriali, Gaia, additional, Vezzani, Bianca, additional, Vitto, Veronica Angela Maria, additional, Antenori, Michele, additional, Lebiedzinska-Arciszewska, Magdalena, additional, Wieckowski, Mariusz R., additional, Giorgi, Carlotta, additional, and Pinton, Paolo, additional

Published
2020
Full Text
View/download PDF

4. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment

Author

Missiroli, Sonia, primary, Perrone, Mariasole, additional, Gafà, Roberta, additional, Nicoli, Francesco, additional, Bonora, Massimo, additional, Morciano, Giampaolo, additional, Boncompagni, Caterina, additional, Marchi, Saverio, additional, Lebiedzinska-Arciszewska, Magdalena, additional, Vezzani, Bianca, additional, Lanza, Giovanni, additional, Kricek, Franz, additional, Borghi, Alessandro, additional, Fiorica, Francesco, additional, Ito, Keisuke, additional, Wieckowski, Mariusz R., additional, Di Virgilio, Francesco, additional, Abelli, Luigi, additional, Pinton, Paolo, additional, and Giorgi, Carlotta, additional

Published
2022
Full Text
View/download PDF

6. Epigenetic Regulation: A Link between Inflammation and Carcinogenesis

Author

Vezzani, Bianca, primary, Carinci, Marianna, additional, Previati, Maurizio, additional, Giacovazzi, Stefania, additional, Della Sala, Mario, additional, Gafà, Roberta, additional, Lanza, Giovanni, additional, Wieckowski, Mariusz R., additional, Pinton, Paolo, additional, and Giorgi, Carlotta, additional

Published
2022
Full Text
View/download PDF

14. CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials

Author

Ding, Lijun, primary, Vezzani, Bianca, additional, Khan, Nusrat, additional, Su, Jing, additional, Xu, Lu, additional, Yan, Guijun, additional, Liu, Yong, additional, Li, Ruotian, additional, Gaur, Anushri, additional, Diao, Zhenyu, additional, Hu, Yali, additional, Yang, Zhongzhou, additional, Hardy, W. Reef, additional, James, Aaron W., additional, Sun, Haixiang, additional, and Péault, Bruno, additional

Published
2019
Full Text
View/download PDF

16. Mesenchymal stem cells: from the perivascular environment to clinical applications

Author

Vezzani, Bianca, Pierantozzi, Enrico, and Sorrentino, Vincenzo

Subjects
Histology, Tissue Engineering, Perivascular cells, Mesenchymal stem cells, Perivascular environment, Pericytes, Perivascular cells, Regenerative medicine, Mesenchymal Stem Cells, Regenerative Medicine, NO, Adult Stem Cells, Animals, Humans, Perivascular environment, Mesenchymal stem cells, Pericytes, Regenerative medicine, 2734
Abstract

Adult stem cells represent a fundamental biological system that has fascinated scientists over the last decades, and are currently the subject of a large number of studies aimed at better defining the properties of these cells, with a prominent focus on improving their application in regenerative medicine. One of the most used adult stem cells in clinical trials are mesenchymal stem cells (MSCs), which are multipotent cells able to differentiate into mature cells of mesodermal lineages. Following the initial studies on MSCs isolated from bone marrow, similar cells were also isolated from a variety of fetal and adult human tissues. Initially considered as identical and equipotent, MSCs from tissues other than bone marrow actually display differences in terms of their plastic abilities, which can be ascribed to the tissue of origin and/or to the procedures used for their isolation. Moreover, results from additional studies suggest that cultured MSCs represent the in vitro version of a subset of in vivo resident cells localized in the perivascular environment. In this review, we will focus our attention on MSCs from tissues other than bone marrow, their in vivo localization and their current applications in clinics.

Published
2018

17. CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.

Author

Lijun Ding, Vezzani, Bianca, Khan, Nusrat, Jing Su, Lu Xu, Guijun Yan, Yong Liu, Ruotian Li, Gaur, Anushri, Zhenyu Diao, Yali Hu, Zhongzhou Yang, Hardy, W. Reef, James, Aaron W., Haixiang Sun, and Péault, Bruno

Subjects
CELL proliferation, CALCIFICATION, PROGENITOR cells, MESENCHYMAL stem cells, CELL surface antigens, CELL membranes
Abstract

The tunica adventitia ensheathes arteries and veins and contains presumptive mesenchymal stem cells (MSCs) involved in vascular remodeling. We show here that a subset of human adventitial cells express the CD10/CALLA cell surface metalloprotease. Both CD10+ and CD10- adventitial cells displayed phenotypic features of MSCs when expanded in culture. However, CD10+ adventitial cells exhibited higher proliferation, clonogenic and osteogenic potentials in comparison to their CD10- counterparts. CD10+ adventitial cells increased expression of the cell cycle protein CCND2 via ERK1/2 signaling and osteoblastogenic gene expression via NF-κB signaling. CD10 expression was upregulated in adventitial cells through sonic hedgehogmediated GLI1 signaling. These results suggest that CD10, which marks rapidly dividing cells in other normal and malignant cell lineages, plays a role in perivascular MSC function and cell fate specification. These findings also point to a role for CD10+ perivascular cells in vascular remodeling and calcification. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

20. CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials

Author

Ding, Lijun, Vezzani, Bianca, Khan, Nusrat, Su, Jing, Xu, Lu, Yan, Guijun, Liu, Yong, Li, Ruotian, Gaur, Anushri, Diao, Zhenyu, Hu, Yali, Yang, Zhongzhou, Hardy, W. Reef, James, Aaron W., Sun, Haixiang, and Péault, Bruno

Abstract

The tunica adventitiaensheathes arteries and veins and contains presumptive mesenchymal stem cells (MSCs) involved in vascular remodeling. We show here that a subset of human adventitial cells express the CD10/CALLA cell surface metalloprotease. Both CD10+and CD10−adventitial cells displayed phenotypic features of MSCs when expanded in culture. However, CD10+adventitial cells exhibited higher proliferation, clonogenic and osteogenic potentials in comparison to their CD10−counterparts. CD10+adventitial cells increased expression of the cell cycle protein CCND2 via ERK1/2 signaling and osteoblastogenic gene expression via NF‐κB signaling. CD10 expression was upregulated in adventitial cells through sonic hedgehog‐mediated GLI1 signaling. These results suggest that CD10, which marks rapidly dividing cells in other normal and malignant cell lineages, plays a role in perivascular MSC function and cell fate specification. These findings also point to a role for CD10+perivascular cells in vascular remodeling and calcification. Sonic hedgehog (SHH)/GLI1/CD10 signaling in the perivascular niche (Figure S8). SHH secreted in the perivascular niche induces GLI1 and CD10 expression. CD10 can upregulate CCND2 expression via ERK1/2 and stimulate NELL1 expression via NF‐κB, which leads to self‐renewal and high osteogenic potential in human adventitial cells.

Published
2020
Full Text
View/download PDF

22. Identification of a Calsequestrin-1 Mutation in a Human Vacuolar Myopathy

Author

Rossi, Daniela, primary, Vezzani, Bianca, additional, Del Re, Valeria, additional, Barone, Virginia, additional, Spinozzi, Simone, additional, Gamberucci, Alessandra, additional, Lorenzini, Stefania, additional, Paolini, Cecilia, additional, Protasi, Feliciano, additional, Reggiani, Carlo, additional, Sorrentino, Vincenzo, additional, and Galli, Lucia, additional

Published
2015
Full Text
View/download PDF

23. A Mutation in theCASQ1Gene Causes a Vacuolar Myopathy with Accumulation of Sarcoplasmic Reticulum Protein Aggregates

Author

Rossi, Daniela, primary, Vezzani, Bianca, additional, Galli, Lucia, additional, Paolini, Cecilia, additional, Toniolo, Luana, additional, Pierantozzi, Enrico, additional, Spinozzi, Simone, additional, Barone, Virginia, additional, Pegoraro, Elena, additional, Bello, Luca, additional, Cenacchi, Giovanna, additional, Vattemi, Gaetano, additional, Tomelleri, Giuliano, additional, Ricci, Giulia, additional, Siciliano, Gabriele, additional, Protasi, Feliciano, additional, Reggiani, Carlo, additional, and Sorrentino, Vincenzo, additional

Published
2014
Full Text
View/download PDF

24. Sars-CoV-2 Infection Prompts IL-1β-Mediated Inflammation and Reduces IFN-λ Expression in Human Lung Tissue

Author

Bianca Vezzani, Margherita Neri, Stefano D’Errico, Alberto Papi, Marco Contoli, Carlotta Giorgi, Vezzani, Bianca, Neri, Margherita, D’Errico, Stefano, Papi, Alberto, Contoli, Marco, and Giorgi, Carlotta

Subjects
Microbiology (medical), IL-6, Infectious Diseases, General Immunology and Microbiology, SARS-CoV-2, IL-1β, COVID-19, IFN-λ, lungs, Immunology and Allergy, Molecular Biology
Abstract

Two years after its spreading, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still responsible for more than 2000 deaths per day worldwide, despite vaccines and monoclonal antibody countermeasures. Therefore, there is a need to understand the immune–inflammatory pathways that prompt the manifestation of the disease to identify a novel potential target for pharmacological intervention. In this context, the characterization of the main players in the SARS-CoV-2-induced cytokine storm is mandatory. To date, the most characterized have been IL-6 and the class I and II interferons, while less is known about the proinflammatory cytokine IL-1β and class III interferons. Here, we report a preliminary study aimed at the characterization of the lung inflammatory context in COVID-19 patients, with a special focus on IFN-λ and IL-1β. By investigating IFN and inflammatory cytokine patterns by IHC in 10 deceased patients due to COVID-19 infection, compared to 10 control subjects, we reveal that while IFN-β production was increased in COVID-19 patients, IFN-λ was almost abolished. At the same time, the levels of IL-1β were dramatically improved, while IL-6 lung levels seem to be unaffected by the infection. Our findings highlight a central role of IL-1β in prompting lung inflammation after SARS-CoV-2 infection. Together, we show that IFN-λ is negatively affected by viral infection, supporting the idea that IFN-λ administration together with the pharmaceutical blockage of IL-1β represents a promising approach to revert the COVID-19-induced cytokine storm.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results